<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2017-03-15" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1L3KKW6</accession>
    <name>A0A1L3KKW6_9VIRU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RdRP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Hubei picorna-like virus 52</name>
        <dbReference type="NCBI Taxonomy" id="1923134"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>unclassified Riboviria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Nature" volume="540" first="539" last="543">
            <title>Redefining the invertebrate RNA virosphere.</title>
            <authorList>
                <person name="Shi M."/>
                <person name="Lin X.D."/>
                <person name="Tian J.H."/>
                <person name="Chen L.J."/>
                <person name="Chen X."/>
                <person name="Li C.X."/>
                <person name="Qin X.C."/>
                <person name="Li J."/>
                <person name="Cao J.P."/>
                <person name="Eden J.S."/>
                <person name="Buchmann J."/>
                <person name="Wang W."/>
                <person name="Xu J."/>
                <person name="Holmes E.C."/>
                <person name="Zhang Y.Z."/>
            </authorList>
            <dbReference type="PubMed" id="27880757"/>
            <dbReference type="DOI" id=".1038/nature20167"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">QCM127295</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KX883920">
        <property type="protein sequence ID" value="APG77955.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009337118.1">
        <property type="nucleotide sequence ID" value="NC_033026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30853606"/>
    <dbReference type="KEGG" id="vg:30853606"/>
    <dbReference type="Proteomes" id="UP000203881">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001205">
        <property type="entry name" value="RNA-dir_pol_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029053">
        <property type="entry name" value="Viral_coat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00680">
        <property type="entry name" value="RdRP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1659"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1982"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="domain" description="RdRP_1" evidence="7">
        <location>
            <begin position="2292"/>
            <end position="2641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2153"/>
            <end position="2187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="APG77955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000203881"/>
        </source>
    </evidence>
    <sequence length="3778" mass="432374" checksum="32ACA539976087C2" modified="2017-03-15" version="1">MQTTMVNTMYMIKAKQFKRQHRVLVEEQILKEDLDFQPREPRQLFSNVEYIWECFPNYEHINYSLFKRDVDELKILLRSIQRQFNIYERNSKSFKEDNLCFYVYELSECALNIFNRRNLLLRNLNSFDDTLLLRTKKYQRLSKYNEILRSIVSQMLYAFEVIKVASKYEKVQLNLYWTKAQQNLNEIMEHNKIPIEPAAIPPARRRYRLERHEFITEPEPFAPIYQEPSRSRQMQRERISGPMTVRLQEILRRKVKKLVKKTTKGVQIQEDLQKVTFSKKGKDLIFEKDDINYHQIVKEFNIQDETSQISSSVLKNVRDYFVNNTNVGQMLTKSEWASIALAVIQIIVNVVQSLTGGKLFLSILGCVAAVGQIIISIIRLAGFGVIDVDIDKLNEHLASYIKAKVESIVSPDDCLPDTDAEIIERIFHTQASNENFQEKFTQERTDVKKKKNMINEIIPLQEHIVHENAVSPWHSLFAKISEINFQNIIKDKTFKIPIIKSLRTSQDNYLCLHHAIWGKRQKDGEVRMSERQVFTLDQIKVYPTDKAQILLMADNIDAPTKDEEVYDKLLEYVNADGFKLMEVCDLYATILNKDIIILNTDLTVKQTYRVPKPTDTIFLKFEINHFERVIFDTFKQKYTDNDSFLQTLKLINNWFYRIDMELVSELNIEVQKHFRNLHFALINDYNNMAIGGFSVQSFSYRTMSPANIAKYATTSGISMLSVIIALTTMFCDPKMQVEGTTNKMLKFFSLTRSSKAEMRENVDLISEFMADMFGIYITPQTINYSLIADMCEKMQDYVDEENTTYLENIKKFYEVKSYVEYCKKQLIMFKTSTKDQTHGYVNAKEQLTGLISKMETKLNSILSVYKTSAVRQETLPVRIYGAAGAGKTEFVSKHLVRLVAENLQIEPSVSTINFGDNKFYPVLNGENFMIYDEFLARRHEDPILGDFNGIHSSVVFLMDSAEVMFKAQPTPFVCSFLLSNSAYTDLSKKLECEAEKGFWSRLEDIHFCNVKQEQSHTRDQIPRGNFDDFTHYEYRQYTTTTGKHRNNPVICKPTPNLRQHYNEEEDKFDDTIYGAGDNMYKVLTLKQIVENISAKIKKFEKKFKNARSFNLKSKIVALKAKKTNITDQQITEHFKDQGYSRIEVMQHLHQGKFQTQEMINFLNSPRFKQEIDTIAIQDQMQDVTQNETLDHFVVNIKGPGGTGKTTIARKAATNLKLMLGMPLVEFNYLDRESAKSITKPSIIILNDCVYDELMYINFYDSLPKACIIFVTHNLVLNRDVVNVQNNLTNNNPVFEYLNTQDDSYFPKRWFNNAIRWYGTQPRAPVWTVDSQAKMQINGFPRRLGLFGMHMHGGMISKRSISSCQMYNTISGFRVFKIKEKGDRKGTLDYEGVTESEIISDIYSKFNSYCKHWKIADIKKLNSQLIDELITQNSQDIDILICAPSAEDLIKFTNNPSALVKTWAIPISTVSSGFTVKTTSRVNNCTFNFDPTEFAIPKNSKPDQYMAVARNMYRIVMQGNVDFTVIVKAGDFKAICKNGVINYCSDYEPEETAFTHTIVDKHITIQFTHENTERNLITNIHLKDFAQIVHNGIPPEEYITDITFDHYLMFLNYINNISTTESEIVNYMRLLDVKQSVKLAEIQEKLGFVRYFKYFESTSIYKFIMVLFGLATGVMFAFLINMLIKMVWGSKKKTTQLEYKGHKIDLVFDWKLNKRIDDRADNLVCDVACDVLNYKDDLINFRELKNLIIQRIKFNLIDNGFIKSDTCVELSNINIQSCKETKVLKTKPVETSNLTKVEGKEKSSMYDKQQKNIKLKTKEADALQAVLDKPSILSKIENNLVKVKTTMGDGLSKSLYGLDIGNGVIITMYHNLCLVNTNSNKYEEADHVQTTVKYLVTDEEFEVKPVMKDPYHDIVIFQIQNRNGYNARANLIKYFIRDKNRTKHTMSEMYTYDRVKNNNNGLNRTKLVGTTANIQLVKDTVNLTKGAFVYVTSVLFCYGMATKEGDCGLPLYALNDSHEILCGLHYGGNASHIGAVQITQEYLETVYSQIMEIEDEEFFDAVEIELDQNELEDETYFEFTEVTFDAFGKEETVVLDNHSLSILQDCDLGSKQTFECLEVGENTEPFGYTHKGARAFRLKSKYIPTPYTDEIDERIPREEMNSATSNKKVEDPSNLPVNRRGEPSILIGQQDKLNDPVDALGKSLGDKYLARALEILIPHYKKLYGRFKHRTLTDLEVINGTYINPRCPSFQNLEPIDRTGSIGYDVTSVFHIQHKNDVLKLFKTLPCGRHIYHYADTEAARYVRRQEEVTLHYWEQDKRCESLVQSNLKCELRPLEKVRVGKTRCFESFTMANSNATRRILGTLFAAIKMYRSEGFAQVGIDTVNFQQLYERFQRLGQFGEAGDFSAWDKHLMPNAIELVTDLWTETFFASWEEVDPTYRIKIRNQIHQILVSNYKAIIIADGNVFTKQRGNCSGAQTTTHLNGSVNDLYRVACILYLIDQHNAHCEISPKSEIKEKYEQIPFIERYTRQMQLDKVEINSMEDILKITDWVDYGDDLASVINLNYVNILNFVSFKMAYNYLFGITYDSPAKDGSIALLTPLIKLSFISRTFHLDENLNIITPRLKLSSINRLLHWTTSIDPDQLKTNLDEIFDELKFYDSSLYSSYIRIVKEIINPYLLKNYRTAYSPPNYHLLRGHYENAVKNVRKEQDAYIDASLRINEKNKILENFQRIIDLFATQGTQLTRRIPDLETNLLSENMTPETIKEYFESLFIRMRVNTQLKISGLPAKVTAENGAVFWSISCEPLYDTSLKEYRKDLQRILQSSRHFTFVTVEDLEIYIPNPLKRIQFRVIQRGESVGKEFSVHELRDALFNIQAATSAAMVDPMPKVTPGAPVPLQDSGLPVGLHQLGFSQKSTAMLAYEYAPLANYTIPVGSTSGKVILNLTRTDLVNEFMRACKTGDSYYNGSFKVKFVSQTNPGLTGTLLIGMTRSKLDSPTETDMLIKQTYQIDGNSSQNFELTISPFTDDVVKARFAWPPSEADDDYYPALVIIVKCDFVSTFDNPSLYSQIQLYTAFSPDFVTFFNGFPKNTGYNTRDAQLSINTVIPLDDVLGKDVRLFTDGNLFTPNIIQVTQSQVEVVASDTLHTAEAFEIKDQKRITRTWATASGWGSFISYENSLLQLRNPKSSTVINSIELLIDYAEGPSFTLNSDVDINEKRIELASIGKVDDRTNYMDIEFTNVWCKCYVSQKERDEKLDRKNMQTFLKYIEPNFVSDVTTYQVLAPLIKVKIDNKNKLQSFSVTFDFTELHDKVGTLFTMLSLNADDTSFNCLLTSVYGFNFTLVIPFDFSKLTQANLANFPDAITLPAGASSLQAVKLPFVVPPASTGAVNAAGSTLLPNISIFDNLSKVLATDKIYQLQLTTKDYSDLVGTFIFHGPKRTCFFNTNKIEYLVSSYMSQELNLRVNNVISLNAQLPVTKYNSSAFVQRNTKSLVRREISAETFNVQGAAASVGAGALMGVGQGLGNYLNMQQNFQNNKELLLLNQGFNKEQAKMMLEMQGANQLAAISAYGENQLGALGIKGANTLNAIAAQGENTKEQMFLQHTLNNLNTPGMSVQRSQNQNFVSGGHQYPDTQNSTTLETPIEQFDLHTGARIKQTSPIQPTVNSAGDDAPNTSVDSLSRAAIENTLFEESYHSPTPNKNPLAGAAGEVRDGMENLVDTIGDYRTLENLNMHDTSSTPTQQTRAMPKNKLANSHGLGADPGTKLSQMKFPGVTTSVSVI</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>