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<entry dataset="TrEMBL" created="2009-02-10" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B7UCZ5</accession>
    <name>B7UCZ5_9RHAB</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">G</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Recombinant vesicular stomatitis Indiana virus rVSV-G/GFP</name>
        <dbReference type="NCBI Taxonomy" id="582817"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Vesiculovirus</taxon>
            <taxon>recombinant Vesiculovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2013" name="J. Virol." volume="87" first="1019" last="1034">
            <title>Highly Attenuated Recombinant Vesicular Stomatitis Virus VSV-12'GFP Displays Immunogenic and Oncolytic Activity.</title>
            <authorList>
                <person name="van den Pol A.N."/>
                <person name="Davis J.N."/>
            </authorList>
            <dbReference type="PubMed" id="23135719"/>
            <dbReference type="DOI" id="10.1128/JVI.01106-12"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2018" name="Nat. Commun." volume="9" first="1029" last="1029">
            <title>Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein.</title>
            <authorList>
                <person name="Nikolic J."/>
                <person name="Belot L."/>
                <person name="Raux H."/>
                <person name="Legrand P."/>
                <person name="Gaudin Y."/>
                <person name="A Albertini A."/>
            </authorList>
            <dbReference type="PubMed" id="29531262"/>
            <dbReference type="DOI" id="10.1038/s41467-018-03432-4"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 17-426</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2020" name="Cell Rep." volume="32" first="108042" last="108042">
            <title>Identification of a pH-Sensitive Switch in VSV-G and a Crystal Structure of the G Pre-fusion State Highlight the VSV-G Structural Transition Pathway.</title>
            <authorList>
                <person name="Beilstein F."/>
                <person name="Abou Hamdan A."/>
                <person name="Raux H."/>
                <person name="Belot L."/>
                <person name="Ouldali M."/>
                <person name="Albertini A.A."/>
                <person name="Gaudin Y."/>
            </authorList>
            <dbReference type="PubMed" id="32814045"/>
            <dbReference type="DOI" id="10.1016/j.celrep.2020.108042"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) OF 17-448</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vesiculovirus glycoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="FJ478454">
        <property type="protein sequence ID" value="ACK77583.1"/>
        <property type="molecule type" value="Other_RNA"/>
    </dbReference>
    <dbReference type="PDB" id="5OYL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.25 A"/>
        <property type="chains" value="A=17-426"/>
    </dbReference>
    <dbReference type="PDB" id="6TIT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.07 A"/>
        <property type="chains" value="A=17-448"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OYL"/>
    <dbReference type="SMR" id="B7UCZ5"/>
    <dbReference type="Proteomes" id="UP000166452">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019062">
        <property type="term" value="P:virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001903">
        <property type="entry name" value="Rhabd_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00974">
        <property type="entry name" value="Rhabdo_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-1161">Viral attachment to host cell</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <keyword evidence="7" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11 12">
        <location>
            <begin position="40"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11 12">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11 12">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11 12">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11 12">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11 12">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK77583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000166452"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="5OYL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6TIT"/>
        </source>
    </evidence>
    <sequence length="511" mass="57491" checksum="0CE40D226F89A1EA" modified="2009-02-10" version="1">MKCLLYLAFLFIGVNCKFTIVFPHNQKGNWKNVPSNYHYCPSSSDLNWHNDLIGTALQVKMPKSHKAIQADGWMCHASKWVTTCDFRWYGPKYITHSIRSFTPSVEQCKESIEQTKQGTWLNPGFPPQSCGYATVTDAEAVIVQVTPHHVLVDEYTGEWVDSQFINGKCSNYICPTVHNSTTWHSDYKVKGLCDSNLISMDITFFSEDGELSSLGKEGTGFRSNYFAYETGGKACKMQYCKHWGVRLPSGVWFEMADKDLFAAARFPECPEGSSISAPSQTSVDVSLIQDVERILDYSLCQETWSKIRAGLPISPVDLSYLAPKNPGTGPAFTIINGTLKYFETRYIRVDIAAPILSRMVGMISGTTTERELWDDWAPYEDVEIGPNGVLRTSSGYKFPLYMIGHGMLDSDLHLSSKAQVFEHPHIQDAASQLPDDESLFFGDTGLSKNPIELVEGWFSSWKSSIASFFFIIGLIIGLFLVLRVGIHLCIKLKHTKKRQIYTDIEMNRLGK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
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