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<entry dataset="TrEMBL" created="2014-04-16" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W5U4T1</accession>
    <name>W5U4T1_SIV</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protease</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Simian T-cell lymphotropic virus 4</name>
        <dbReference type="NCBI Taxonomy" id="1454033"/>
        <lineage>
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            <taxon>Artverviricota</taxon>
            <taxon>Revtraviricetes</taxon>
            <taxon>Ortervirales</taxon>
            <taxon>Retroviridae</taxon>
            <taxon>Orthoretrovirinae</taxon>
            <taxon>Lentivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2014" name="Emerg. Microbes Infect." volume="3" first="e7" last="e7">
            <title>A gorilla reservoir for human T-lymphotropic virus type 4.</title>
            <authorList>
                <person name="LeBreton M."/>
                <person name="Switzer W.M."/>
                <person name="Djoko C.F."/>
                <person name="Gillis A."/>
                <person name="Jia H."/>
                <person name="Sturgeon M.M."/>
                <person name="Shankar A."/>
                <person name="Zheng H."/>
                <person name="Nkeunen G."/>
                <person name="Tamoufe U."/>
                <person name="Nana A."/>
                <person name="Le Doux Diffo J."/>
                <person name="Tafon B."/>
                <person name="Kiyang J."/>
                <person name="Schneider B.S."/>
                <person name="Burke D.S."/>
                <person name="Wolfe N.D."/>
            </authorList>
            <dbReference type="PubMed" id="26038495"/>
            <dbReference type="DOI" id="10.1038/emi.2014.7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR001969">
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    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
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    <dbReference type="InterPro" id="IPR021109">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00077">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="4">
        <location>
            <begin position="83"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AHH34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000161274"/>
        </source>
    </evidence>
    <sequence length="213" mass="22815" checksum="12CF8060FC6A945B" modified="2014-04-16" version="1">MSGPIPLEARLPPAKNPAGGRRTPPSGFACPSPGGKKLPRGGELVSPRPGNMPSLLPLVSLWQAQQPLLNIKVSFFDRPPLASQALLDTGADLTVMPQVLARGLTDLQDTTILGAGGKTHSQFKLLRCPVHVYLPFRRAPVSLPSCLIDTKNEWTIIGRDVLQQCQGALYLPEDLPAPTQLSPVTTPAVIGLEHLPEPPEVSQFPLNLNASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W5U570</accession>
    <name>W5U570_SIV</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Envelope glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Simian T-cell lymphotropic virus 4</name>
        <dbReference type="NCBI Taxonomy" id="1454033"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Pararnavirae</taxon>
            <taxon>Artverviricota</taxon>
            <taxon>Revtraviricetes</taxon>
            <taxon>Ortervirales</taxon>
            <taxon>Retroviridae</taxon>
            <taxon>Orthoretrovirinae</taxon>
            <taxon>Lentivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Emerg. Microbes Infect." volume="3" first="e7" last="e7">
            <title>A gorilla reservoir for Human T-lymphotropic virus type 4.</title>
            <authorList>
                <person name="LeBreton M."/>
                <person name="Switzer W.M."/>
                <person name="Djoko C.F."/>
                <person name="Gillis A."/>
                <person name="Jia H."/>
                <person name="Sturgeon M.M."/>
                <person name="Shankar A."/>
                <person name="Zheng H."/>
                <person name="Nkeunen G."/>
                <person name="Tamoufe U."/>
                <person name="Nana A."/>
                <person name="Le Doux Diffo J."/>
                <person name="Tafon B."/>
                <person name="Kiyang J."/>
                <person name="Schneider B.S."/>
                <person name="Burke D.S."/>
                <person name="Wolfe N.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Ggo50539</strain>
            <strain evidence="12">Ggo51323</strain>
            <strain evidence="13">Ggo51461</strain>
            <strain evidence="14">Ggo51573</strain>
            <strain evidence="15">Ggo51647</strain>
            <strain evidence="16">Ggo51657</strain>
        </source>
    </reference>
    <reference evidence="17 18 19" key="2">
        <citation type="journal article" date="2014" name="Emerg. Microbes Infect." volume="3" first="e7" last="e7">
            <title>A gorilla reservoir for human T-lymphotropic virus type 4.</title>
            <authorList>
                <person name="LeBreton M."/>
                <person name="Switzer W.M."/>
                <person name="Djoko C.F."/>
                <person name="Gillis A."/>
                <person name="Jia H."/>
                <person name="Sturgeon M.M."/>
                <person name="Shankar A."/>
                <person name="Zheng H."/>
                <person name="Nkeunen G."/>
                <person name="Tamoufe U."/>
                <person name="Nana A."/>
                <person name="Le Doux Diffo J."/>
                <person name="Tafon B."/>
                <person name="Kiyang J."/>
                <person name="Schneider B.S."/>
                <person name="Burke D.S."/>
                <person name="Wolfe N.D."/>
            </authorList>
            <dbReference type="PubMed" id="26038495"/>
            <dbReference type="DOI" id="10.1038/emi.2014.7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KF029428">
        <property type="protein sequence ID" value="AHH34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KF029429">
        <property type="protein sequence ID" value="AHH34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KF029430">
        <property type="protein sequence ID" value="AHH34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KF029431">
        <property type="protein sequence ID" value="AHH34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AHH34967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AHH34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Genome"/>
    </dbReference>
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        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000103986">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000142948">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000145717">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000161274">
        <property type="component" value="Genome"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019064">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019062">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="PTHR10424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1169">Fusion of virus membrane with host cell membrane</keyword>
    <keyword evidence="2" id="KW-1168">Fusion of virus membrane with host membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="7" id="KW-1043">Host membrane</keyword>
    <keyword evidence="3" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-1161">Viral attachment to host cell</keyword>
    <keyword evidence="16" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="4" id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <keyword evidence="2" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AHH34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AHH34955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AHH34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AHH34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AHH34967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AHH34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000097469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000097785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000103986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000161274"/>
        </source>
    </evidence>
    <sequence length="485" mass="53557" checksum="5399F3A2AAC4AB57" modified="2014-04-16" version="1">MGNVFFLTLLATLGIPVLQASRCTITVGISSYHSSPCSPAQPLCTWALDLVSITKDQLLYPPCQNLITYSNYHKTYSLYLFPHWVQKPLRRGLGYYSASYSDPCSLQCPYLGSQSWTCPYTGPVSSPTWRFSTDVNFTQEVSRVSLKLHFSKCGSSLTLLIDAPGYDPLWYLTSEPTQEPPTPPPLVSDSDLEHVLTPSASWASKMLTLIHLTLQSTNYSCMVCIDRASLSSWHVLYTPNISSNAPSKPIVRPSLALSAPRPQPFPWTHCYQPQVQAVTTAKCNNSIILPPFSLSPLPGAPLTRRRRAVPVAVWLVSALAAGTGIAGGVTGSLSLASSRSLLSEVDKDISHLTRAIVKNHQNILRVAQYAAQNRRGLDLLFWEQGGLCKAIQEQCCFLNISNTHISVLQERPPLETRVTTGWGLNWDLGLSQWAREALQTGITLLALLLLIIILGPCIIRQLQALPQRLQQRPDQYPLLNPETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>W5U5R1</accession>
    <name>W5U5R1_SIV</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Polymerase</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Simian T-cell lymphotropic virus 4</name>
        <dbReference type="NCBI Taxonomy" id="1454033"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Pararnavirae</taxon>
            <taxon>Artverviricota</taxon>
            <taxon>Revtraviricetes</taxon>
            <taxon>Ortervirales</taxon>
            <taxon>Retroviridae</taxon>
            <taxon>Orthoretrovirinae</taxon>
            <taxon>Lentivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2014" name="Emerg. Microbes Infect." volume="3" first="e7" last="e7">
            <title>A gorilla reservoir for human T-lymphotropic virus type 4.</title>
            <authorList>
                <person name="LeBreton M."/>
                <person name="Switzer W.M."/>
                <person name="Djoko C.F."/>
                <person name="Gillis A."/>
                <person name="Jia H."/>
                <person name="Sturgeon M.M."/>
                <person name="Shankar A."/>
                <person name="Zheng H."/>
                <person name="Nkeunen G."/>
                <person name="Tamoufe U."/>
                <person name="Nana A."/>
                <person name="Le Doux Diffo J."/>
                <person name="Tafon B."/>
                <person name="Kiyang J."/>
                <person name="Schneider B.S."/>
                <person name="Burke D.S."/>
                <person name="Wolfe N.D."/>
            </authorList>
            <dbReference type="PubMed" id="26038495"/>
            <dbReference type="DOI" id="10.1038/emi.2014.7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.</text>
            <dbReference type="EC" id="3.1.13.2"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KF029428">
        <property type="protein sequence ID" value="AHH34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004533">
        <property type="term" value="F:exoribonuclease H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036862">
        <property type="entry name" value="Integrase_C_dom_sf_retrovir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001037">
        <property type="entry name" value="Integrase_C_retrovir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003308">
        <property type="entry name" value="Integrase_Zn-bd_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00552">
        <property type="entry name" value="IN_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02022">
        <property type="entry name" value="Integrase_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50122">
        <property type="entry name" value="SSF50122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51027">
        <property type="entry name" value="INTEGRASE_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="16">
        <location>
            <begin position="58"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="17">
        <location>
            <begin position="475"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="664"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase-type" evidence="19">
        <location>
            <begin position="838"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Integrase-type" evidence="14">
        <location>
            <begin position="838"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AHH34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000161274"/>
        </source>
    </evidence>
    <sequence length="908" mass="100999" checksum="5DF23DC9C37F7FF5" modified="2014-04-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-04-16" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W5UB23</accession>
    <name>W5UB23_SIV</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Gag protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Simian T-cell lymphotropic virus 4</name>
        <dbReference type="NCBI Taxonomy" id="1454033"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Pararnavirae</taxon>
            <taxon>Artverviricota</taxon>
            <taxon>Revtraviricetes</taxon>
            <taxon>Ortervirales</taxon>
            <taxon>Retroviridae</taxon>
            <taxon>Orthoretrovirinae</taxon>
            <taxon>Lentivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2014" name="Emerg. Microbes Infect." volume="3" first="e7" last="e7">
            <title>A gorilla reservoir for human T-lymphotropic virus type 4.</title>
            <authorList>
                <person name="LeBreton M."/>
                <person name="Switzer W.M."/>
                <person name="Djoko C.F."/>
                <person name="Gillis A."/>
                <person name="Jia H."/>
                <person name="Sturgeon M.M."/>
                <person name="Shankar A."/>
                <person name="Zheng H."/>
                <person name="Nkeunen G."/>
                <person name="Tamoufe U."/>
                <person name="Nana A."/>
                <person name="Le Doux Diffo J."/>
                <person name="Tafon B."/>
                <person name="Kiyang J."/>
                <person name="Schneider B.S."/>
                <person name="Burke D.S."/>
                <person name="Wolfe N.D."/>
            </authorList>
            <dbReference type="PubMed" id="26038495"/>
            <dbReference type="DOI" id="10.1038/emi.2014.7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KF029428">
        <property type="protein sequence ID" value="AHH34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000161274">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019013">
        <property type="term" value="C:viral nucleocapsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003139">
        <property type="entry name" value="D_retro_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045345">
        <property type="entry name" value="Gag_p24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000721">
        <property type="entry name" value="Gag_p24_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008916">
        <property type="entry name" value="Retrov_capsid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010999">
        <property type="entry name" value="Retrovr_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02228">
        <property type="entry name" value="Gag_p19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00607">
        <property type="entry name" value="Gag_p24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19317">
        <property type="entry name" value="Gag_p24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47836">
        <property type="entry name" value="SSF47836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="SSF47943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="9" id="KW-0946">Virion</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AHH34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000161274"/>
        </source>
    </evidence>
    <sequence length="424" mass="46725" checksum="E2EEDB99CD151AE9" modified="2014-04-16" version="1">MGQTHTSSPVPKAPRGLSTHHWLNFLQAAYRLQPGPSEFDFHQLRRFLKLALQTPVWLNPIDYSLLASLIPKGYPGRVTEIVNILLRAHPPPSAPAISMPSATGPAPAPQPQEAHTPPPYAEPAALQCLPIMHSHGAPSSHRPWQMKDLQAIKQEISTSAPGSPQFMQTIRLAIQQFDPTAKDLHDLLQYLCSSLIVSLHHQQLQALIAEAETRGLTGYNPMAGPLRVQANNPAQQGLRREYQSLWLAAFAALPGNTRDPSWAAILQGLEEPYCAFVERLNVALDNGLPEGTPKEPILRSLAYSNANKECQKLLQARGHTNSPLGEMLRACQAWTPKDKTKVLVVQPRKTPPTQPCFRCGKVGHWSRDCTQPRPPPGPCPLCQDPSHWKRDCPQLKTPPEVEEPLLADLPALLPEEKNSPGGEN</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>