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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
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                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
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                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
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                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
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                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
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                <person name="Lo C.C."/>
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                <person name="Avery A.C."/>
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            <dbReference type="PubMed" id="26543105"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">31286</strain>
        </source>
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            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
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    <comment type="similarity">
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                <person name="Vuyisich M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">31286</strain>
        </source>
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            <dbReference type="EMBL" id="ALE14742.1"/>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
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                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
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                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
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            <dbReference type="PubMed" id="26543105"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T967</accession>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
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                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173927.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100441"/>
    <dbReference type="KEGG" id="vg:26100441"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="164" mass="18489" checksum="74558386EC681C14" modified="2015-12-09" version="1">MDSGHVVDLSLKHSNTNPPERRAVETIRYAPPMDLDESKLVIDIPDSPVESGRLLRNKRHMEQKAYEQQFVKLPSPKWIEERCEPSVSRSPKGGTQKILTPPVVPNTTTSIPQSEEDVEKFMKMDPQNVSSVMKSVLFVPANSPLNIKKLQETPDVSIRFVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T968</accession>
    <name>A0A0M3T968_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F22</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">31286</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173937.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100451"/>
    <dbReference type="KEGG" id="vg:26100451"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030195">
        <property type="entry name" value="ENT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF9">
        <property type="entry name" value="PTHR10332:SF9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ALE14772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="429" mass="48193" checksum="12D7B0CD8C1CCAC8" modified="2015-12-09" version="1">MVSDLHAVAIMSHTIEDKYKYIWIVFLILSLCSVLPWNVYITATSYFTSKLINNISLITPPNSTNYSSILEGIFTNSITLCAVCSVLIFTCFSPIIQENISEPVRIAGSLLGILGIFLFTSFLVLVPMEITLFFIIILITVILANSLGSILQASVFNLVSLFPSIYTHAFIVGQGLAGLYSICIMLLITSTGLPLTDSTFIYFIVASAIFALSIFLYFTLHTLRFFKMFSIVKKPYDAFQHIPLVKHNARKKFKYKNLFMPATSICALYVTTIGVFPSVAVDIKPSTLNSTTEITTNQYFVPIICFLNYSIWELIGRMLTMFIIWPKKTITWIPLLVCFRIVLIPLILFCNIHPRHNLPVYFLNPGWFALFIGVLALSNGYFTSLCIITMFTNINPKRHTKPPETVINIIMVLGSAIGAIISFLLKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T970</accession>
    <name>A0A0M3T970_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear egress protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NEC2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a heterohexameric complex with NEC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host nucleus inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="2">Localizes also at the transient membrane of perinuclear virions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Phosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae NEC2 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173947.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100461"/>
    <dbReference type="KEGG" id="vg:26100461"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044201">
        <property type="term" value="C:host cell nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04024">
        <property type="entry name" value="HSV_NEC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007626">
        <property type="entry name" value="Herpesvirus_viron_egress-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04541">
        <property type="entry name" value="Herpes_U34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1043">Host membrane</keyword>
    <keyword evidence="2" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="2" id="KW-0426">Late protein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ALE14782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="288" mass="32605" checksum="DA276C031388C265" modified="2015-12-09" version="1">MNSGKRLLSELCQVVTSFLCQPGVTIDISSCRVGQHIFSKGVTQPICTVKLEHGHIYNVEFVYRYWYHILRSQKYPLSPVFIISNNGLTVTLKCFVCEPRDIYSQFGNCQNIDFDVYLPKNSNVILSQDDFLKFKTNLVFSKDLNVYNSMVVCRTYLTENRQALQFLVVKPNNPKRVSAILHAIRSVVGMSIHNIGDTYTPHENCDVITEELVNNVMSRKPIRTAHKEPHSDSSDGQKPHPIDKQDSLNTASTSIWCGLKYNLITVSTLVKGLIGAVFVLIVIQLFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T972</accession>
    <name>A0A0M3T972_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F25</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173957.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100471"/>
    <dbReference type="KEGG" id="vg:26100471"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ALE14792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="184" mass="19106" checksum="B0D7AD55A265619F" modified="2015-12-09" version="1">MIHLIMRTCQVLGLLLVILCVSYGNTTTSPSSSNTSTLSSTGNSSTATTTGTSGTISQSTATNSSIASLPTTLSSSSSTSNSTSISTTVVNTSTSTTSKHHQDIGTMIFFVGWFFGLGLFVLFVILVVLCCLKKERRSRLSRRPLPPIPSGSVESGLGGSIPSSYSGSTGSDSETEATEEEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T9C3</accession>
    <name>A0A0M3T9C3_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F10</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173881.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100395"/>
    <dbReference type="KEGG" id="vg:26100395"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ALE14716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="155" mass="18036" checksum="9817FA3ED9A44170" modified="2015-12-09" version="1">MLDTVICRICMCNIAVDNKCSPCNCKGTLAFVHQVCLKSWIQVSQQTKCNICDTCYNFKWLPFLEWTLPEIDYIEKDLLKSVCLGFGVMVILCLAVAIILICIFATPIIHVFWQLFYIFCLVLCFMYMVIVYRVVIYDDLMIIFAVFKWHNTQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T9C5</accession>
    <name>A0A0M3T9C5_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F15</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">31286</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intercrine beta (chemokine CC) family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173891.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100405"/>
    <dbReference type="KEGG" id="vg:26100405"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000827">
        <property type="entry name" value="Chemokine_CC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="PTHR12015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="SSF54117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00472">
        <property type="entry name" value="SMALL_CYTOKINES_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCY" evidence="2">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ALE14726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="102" mass="11751" checksum="14FE397830C6CC32" modified="2015-12-09" version="1">MMSVGRNLLLVALVIVLFFLCCGETYSSDSSDCCLRHSTRPIPFKVLQSYQHQLPTIGCHLNAIVFYTVKRRTICANPGDKWVRLAMKFIDKKNNSTMRYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T9C7</accession>
    <name>A0A0M3T9C7_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triplex capsid protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRX2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with TRX1 and major capisd protein/MCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae TRX2 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173901.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100415"/>
    <dbReference type="KEGG" id="vg:26100415"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04019">
        <property type="entry name" value="HSV_TRX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002690">
        <property type="entry name" value="Herpes_capsid_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01802">
        <property type="entry name" value="Herpes_V23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="1" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="305" mass="34545" checksum="83E78A3C7A9EF972" modified="2015-12-09" version="1">MQVDKKIIVTLTARLFADEISKLQERIGSIVPLQDPYRLQNLNSVGLASVCSPHRNYDYIEIYHFLSKATLAILDEVTPDSLIFTRIDHTENYHLKNVYRPFFQWDSHTKLSIIPPLLGLDDATVKLESNQFELIFPLVVPKDLGQTILQKLLLYNIYTRLHEIDPDGVNLGDAHFYTTNISYMGRMYTLDIASTNSESTLKLLDNLCMALCVLASLVPMGCYRIAPALIRHNQHHMLQMFMEFLPDFIVNIPDEPIASMADDVVKMEAFLTYLQSLGSIFNLAPSVHLSGYSSDTLSGTGWLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T9C8</accession>
    <name>A0A0M3T9C8_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF34</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173911.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100425"/>
    <dbReference type="KEGG" id="vg:26100425"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004280">
        <property type="entry name" value="Herpes_UL95"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03038">
        <property type="entry name" value="Herpes_UL95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="329" mass="37515" checksum="39F972718BB430B9" modified="2015-12-09" version="1">MFNLTNLMNDGDPTESKKYYSSVGLAMSLCESVPGQFKLIETPINSFVLVTNVMPEDTRPWNSHNSKEIDFSNIHLPRLKKLDELTHWDVHKSSHNTTDPKTNPLDQEPPSHYLVYSSNSWKRAILLDKQEVIKEALDKLALPINWKGLVTEDPYPLIWLLFYGQNSFCSNNECLFFKKFGYRGAILFPPHVYSPSDDSLSFITNVCKYIKFLYGDQFKGEMIQQGSELPFDLNRLIDALAKLKFVCDSGVYISRTCLLCNLYKQNLTRSRISVGNFYGSIILGGCGKKYLAQDIQTERCVDSGDSILCPSYDLTRLLNDLRDPINGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T9D0</accession>
    <name>A0A0M3T9D0_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF45</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173921.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100435"/>
    <dbReference type="KEGG" id="vg:26100435"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="217" mass="23634" checksum="94360BE72887DA5C" modified="2015-12-09" version="1">MAMFYRKHSISSGSDDPEECGLPGEDWSSDDVFETPANNVTKTCKKKNRKLHWSSTSDSGSSDQDHTEESSDGEEDGQEKNVAAFINVKAKEASRLWPDTSSGDSDIEGTSNSEDESVKALLNKKAKEASKMGSDTSDSEEDISAFIKTQAKKASKIGSDTSNSEESDDPCTHSKGRKRGRSNKDTTQGSSSKMRCVPLTGTPPITGNSNYMWPWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T9D2</accession>
    <name>A0A0M3T9D2_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ORF52</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">31286</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae BLRF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173931.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100445"/>
    <dbReference type="KEGG" id="vg:26100445"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008642">
        <property type="entry name" value="Herpes_BLRF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05812">
        <property type="entry name" value="Herpes_BLRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ALE14766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="132" mass="14586" checksum="24C78312EBDD7292" modified="2015-12-09" version="1">MASKKGTPTHDDLVEQLEKLKIENKNLKKKLKKISEEDGGTGVSCSSTLLTENAKKVMVSAVTSMLTKQARDRIEQKVMDITSSAVTKEDFEKAVNNVTMRIEVSTAEGEGRATSRKSRTRARSKSRSKQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M3T9D5</accession>
    <name>A0A0M3T9D5_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">31286</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173951.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100465"/>
    <dbReference type="KEGG" id="vg:26100465"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="5">
        <location>
            <begin position="14"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ALE14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="294" mass="33758" checksum="BE4F42FD9723315F" modified="2015-12-09" version="1">MCSLYDEAAHEELQYLSLVKQILDKGDRRPDRTGVGTLSLFGPQLRFSLHDSFPLLTTKRVYWKGVVEELLWFIRGSTNARELSSKGVKIWNPHIRSDLLNREQFPDTAPGDLGPIYGFQWRHYGATYTGCQADYTGKGIDQLLNVIHDIEHNRYSRRMIMCAWGPFMNGMALPPCHVLCQFYVSQNKLSCQLYQRSGDMGLGVPFNIASYSLLTYMIAHITGLEPWELIHCIGDAHVYLNHIQPLQLQLTRKPTPFPKLKIKRRVACIDDFVADDFELENYRPHPAIKMDVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LR00</accession>
    <name>A0A0M4LR00_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F5</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173876.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100390"/>
    <dbReference type="KEGG" id="vg:26100390"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="515" mass="54291" checksum="1BFF307E0E35F01F" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LR08</accession>
    <name>A0A0M4LR08_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F13</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173889.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100403"/>
    <dbReference type="KEGG" id="vg:26100403"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="201" mass="23052" checksum="23CB31045D469C49" modified="2015-12-09" version="1">MYLEDLENPDRPNQCTGLVKIAFISMFGACINILIIGLIYFMKNTAIERKNQSPIQRPECEHALCFNFERQTINDALQFIQKNTTDRIIKEPYKNPDNSSQASTNSTNTSSQTHSSEDKVEIFFDPDKDPWPQFYVTQGGVKTPVYTLPFLDALGLLRTPCTLSCQDRNDLGTQWNDSVEKWEEKNNKNWTKGKILLQSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LR16</accession>
    <name>A0A0M4LR16_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF27</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173902.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100416"/>
    <dbReference type="KEGG" id="vg:26100416"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="286" mass="32682" checksum="E44D645BBC8992AA" modified="2015-12-09" version="1">MENIPHILKIAQLEDNVVHQVALCEDGVVAETFYKNVVSDVFQFESQEMLMSSEKASKDKRCKYKISIILSLCLYLGFTVMYIYYFNPLIQIYRYTIFRYGKILPYDLVRPNGQDVLNKCDENIFCNVHFKAMAIKTSKGTLFPNFTKDGNVSGDYYAALWHAAAILSNTSCRSTINITSSDGSVTSNISESIFNLVAEKIYSSIFLIQSKCHHEAVYAINSPNRFSKYKINYKNYMTLPNATECASSWDTVFNKSYYAIVNYTSCDFRYSTLSEVLGFPILVSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LR24</accession>
    <name>A0A0M4LR24_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Shutoff alkaline exonuclease</fullName>
            <shortName evidence="7">SOX</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-&gt; 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity. Also acts as a cytoplasmic RNA endonuclease that induces degradation of the majority of the cellular messenger RNAs during early lytic infection. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and evasion from host immune response. Internally cleaves host mRNAs which are then degraded by the cellular exonuclease XRN1. Bypasses therefore the regulatory steps of deadenylation and decapping normally required for XRN1 activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with the DNA polymerase, the DNA polymerase processivity factor, and the major DNA binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the herpesviridae alkaline nuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173914.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100428"/>
    <dbReference type="KEGG" id="vg:26100428"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039595">
        <property type="term" value="P:induction by virus of catabolism of host mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039657">
        <property type="term" value="P:suppression by virus of host gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04009">
        <property type="entry name" value="HSV_AN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001616">
        <property type="entry name" value="Herpes_alk_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00924">
        <property type="entry name" value="ALKEXNUCLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 7" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="1 7" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="2 7" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Required for function" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Required for function" evidence="7">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="site" description="Required for function" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="site" description="Required for function" evidence="7">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ALE14749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="481" mass="54805" checksum="9E84476D8FC25E22" modified="2015-12-09" version="1">MVHFFSTTPIFDELDGLSIDEIKEQLSQLTFSNFIKCKPIQDFLKSSSFKQPRLPNMRYVYLYYLFQKIGDYIGDSKVLNIFKNVTNTDVILNVSEVYKICDKMDHHTQTGICLAIESITRGQHNNVLWHVLRDGIISSSKFYQAVTFQSVSKKLFCPWPIENDYYVASPLAFGLRCENAMKTVMAQLICPKKKTTSFEFGFMQSPKDCIFGVSIDMCTNVTTDENDILVFNADSEIYEIKCRYKYLFSKMECDSTYLKYKDLYSNPCKGTFINFINSVSRPGVEYVPPGKLPSKTDFLITSDTAWAGQVKRKRNITQLHKAISMGLKANRFIESDVFILTDPSETNGKIDIKARLSIPLYVNPDHSYFYQVLLQYKVVTNYIQYRSPGGLGTLKNYLISGFFRKRNYCDPIDCVIGESGTLDPTVEIPVLVIVTQVIIPKTIVQDSLIKAANFWCSSAQAEFKQVPWVSSALFADGDITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LR31</accession>
    <name>A0A0M4LR31_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF49</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173926.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100440"/>
    <dbReference type="KEGG" id="vg:26100440"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006878">
        <property type="entry name" value="Herpes_BBRF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04793">
        <property type="entry name" value="Herpes_BBRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="263" mass="31223" checksum="E739C401EF3820D7" modified="2015-12-09" version="1">MNRKKTLHKTPPQLENYFIAPKCMILDKYTLKKCDFIYILKIYKILLNNRITSYKIIPDIFTVLKKATVHLATYTRNLHFKLKLLDLQQKCTDIQELTRLLPYILQNLKQDHGQCIYNLFVNIYPCLKWYKSALIGLKPCIKEEVIQILKCDENVYCLSYLKKICKRLVCNTNNYIQSDLLLDLTFSIAFNQTVFWIAVAKLYEKTLNDELLDEQITEIYSLLNFGIRRFMNTFVSPLNHTTTLRDIENLICYLENMHNKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LR39</accession>
    <name>A0A0M4LR39_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF59</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173939.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100453"/>
    <dbReference type="KEGG" id="vg:26100453"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007013">
        <property type="entry name" value="DNA_pol_proc_fac_herpes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04929">
        <property type="entry name" value="Herpes_DNAp_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="383" mass="43126" checksum="DCC581EFA04D0C36" modified="2015-12-09" version="1">MEAKITTHYARFNIDNIKKAMKVYSHIKIPAKKGLLQIVGSKTHQEFQILANVGTGGVLVYKVFNPFDKFTIYEDGEENVSISFQNQPLGNNYIHGKELFSPIVNQASMTFYKRPGKNEPEFVKSEFTLNDNDTRLCHYTSITSWPIPIHTFKMKAIHSRLALSIKTATMLQKWLREKKGSSDQVVKITVNQSLLVAVFTIGENSKTIDFQPVTCEPENALKVAEKQGDYGLILTNLEFYANLDSLIQSLGLCKLAATYTPCICFHPENVVEVIGLPLKGVKDFNSSVSVLLIKARIKAPQRESPSTLRTKYSSLEDSEEETEEAINYLTQNQGISATNTLDDLVREEIEKEKVRHKSLGTSSKKRKLEDINSSKSKHSKITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LR46</accession>
    <name>A0A0M4LR46_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F23</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173952.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100466"/>
    <dbReference type="KEGG" id="vg:26100466"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="56" mass="6874" checksum="5A2E0F03BA6EBF85" modified="2015-12-09" version="1">MLLRFWLIVHISMHFAYVVNLHFMFFSLVNESNPQYHFYPCYKIIFDSLKTLNSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LRQ5</accession>
    <name>A0A0M4LRQ5_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F11</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173882.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100396"/>
    <dbReference type="KEGG" id="vg:26100396"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="71" mass="7906" checksum="936BC26ACF2A9106" modified="2015-12-09" version="1">MDNTGGKMGNKKKASLIDEVAVCLVLIIVLTVLVVLLLASYCRLVDPRFTHDMLHMLLDPGYCGRKRICMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LRR1</accession>
    <name>A0A0M4LRR1_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF18</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae UL79 family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173894.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100408"/>
    <dbReference type="KEGG" id="vg:26100408"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004290">
        <property type="entry name" value="Herpes_UL79"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03049">
        <property type="entry name" value="Herpes_UL79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="256" mass="29474" checksum="B3284F0E89534ECC" modified="2015-12-09" version="1">MDILGKYVSRGKSLSPGLEELMWKMLRNQSLNSLHNQELRFLHFVLCHMYNLCLNSLLFRDAIANAGCRDDVVLSRKVPLEIWKLIYDGCVEMGVTSSTFQSDKSRGELWLYYNTHPRLLTGLTNYITQRLGLKHHVKISEHNLIDGNYLYSLGSVIPSRILMVIAFCLVNWGRMVAEPWIRLFSRKIFILFLLLSGGLVLNEHFLVSGYNGPVDTVIQDIQAMTGIVPIPHLRQEEASHENFLDFLFIFDNNMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LRR8</accession>
    <name>A0A0M4LRR8_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tripartite terminase subunit 3</fullName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Terminase large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRM3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Host nucleus</location>
        </subcellularLocation>
        <text evidence="6">Responsible for the nuclear localization of the two others subunits TRM1 and TRM2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the herpesviridae TRM3 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173906.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100420"/>
    <dbReference type="KEGG" id="vg:26100420"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04013">
        <property type="entry name" value="HSV_TRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003498">
        <property type="entry name" value="DNA_pack_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038435">
        <property type="entry name" value="DNA_pack_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003499">
        <property type="entry name" value="DNA_pack_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033663">
        <property type="entry name" value="HSV_TRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02499">
        <property type="entry name" value="DNA_pack_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02500">
        <property type="entry name" value="DNA_pack_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 6" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="2 6" id="KW-1188">Viral release from host cell</keyword>
    <feature type="domain" description="DNA_pack_N" evidence="8">
        <location>
            <begin position="43"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pack_C" evidence="7">
        <location>
            <begin position="332"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Walker A motif" evidence="6">
        <location>
            <begin position="216"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="For ATPase activity" evidence="6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="6">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="6">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="6">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ALE14741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="686" mass="76991" checksum="3E85ABEA0A9974C3" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LRS6</accession>
    <name>A0A0M4LRS6_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Portal protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamerizes. Interacts with terminase subunits TRM1 and TRM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae portal protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173919.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100433"/>
    <dbReference type="KEGG" id="vg:26100433"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044423">
        <property type="term" value="C:virion component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04012">
        <property type="entry name" value="HSV_PORTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002660">
        <property type="entry name" value="Herpes_Portal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01763">
        <property type="entry name" value="Herpes_UL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="1" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="578" mass="65790" checksum="E8E8DB0DC42A7D5B" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LRT4</accession>
    <name>A0A0M4LRT4_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ORF53</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Plays also a critical role in virion morphogenesis.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173932.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100446"/>
    <dbReference type="KEGG" id="vg:26100446"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04037">
        <property type="entry name" value="HSV_GN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005211">
        <property type="entry name" value="Herpes_glycoprotein_N_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034707">
        <property type="entry name" value="HSV_GN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03554">
        <property type="entry name" value="Herpes_UL73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Herpes_UL73" evidence="4">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ALE14767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="90" mass="9949" checksum="B900FDBDFEB379FF" modified="2015-12-09" version="1">MTYIPTLVTLIQVVTLIGANGSTSTTPSTPTPSTTPSFYDYSCNSDTYTLELTSFSSIWAIINMVVILISTIIYLIYICFNKFVNTMTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LRU0</accession>
    <name>A0A0M4LRU0_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ORF64</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the herpesviridae large tegument protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173944.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100458"/>
    <dbReference type="KEGG" id="vg:26100458"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039648">
        <property type="term" value="P:modulation by virus of host protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006928">
        <property type="entry name" value="Herpes_teg_USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04843">
        <property type="entry name" value="Herpes_teg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51521">
        <property type="entry name" value="HTUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="2" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1127">Modulation of host ubiquitin pathway by viral deubiquitinase</keyword>
    <keyword evidence="5" id="KW-1130">Modulation of host ubiquitin pathway by virus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0946">Virion</keyword>
    <keyword evidence="3 11" id="KW-0920">Virion tegument</keyword>
    <feature type="domain" description="Peptidase C76" evidence="14">
        <location>
            <begin position="16"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2147"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1269"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ALE14779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="2259" mass="256249" checksum="F619FEDC59B45674" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4LRU9</accession>
    <name>A0A0M4LRU9_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ORF75</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">31286</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173956.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100470"/>
    <dbReference type="KEGG" id="vg:26100470"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075733">
        <property type="term" value="P:intracellular transport of virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010077">
        <property type="entry name" value="Herpes_virus_tegument"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024346">
        <property type="entry name" value="Tegument_herpes_virus_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12818">
        <property type="entry name" value="Tegument_dsDNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01739">
        <property type="entry name" value="tegu_FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <keyword evidence="2" id="KW-0920">Virion tegument</keyword>
    <feature type="domain" description="Tegument_dsDNA" evidence="5">
        <location>
            <begin position="270"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="847"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ALE14791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="1330" mass="150383" checksum="0CD531DBB848E3D6" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M123</accession>
    <name>A0A0M4M123_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F4</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173875.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100389"/>
    <dbReference type="KEGG" id="vg:26100389"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="114" mass="12757" checksum="A00CBADDC4DD65AB" modified="2015-12-09" version="1">MFDDEGRPIYGPFLSPRCEFILKEQIGQQLLYYRRQQNLYKTHRPQTEELPEGSPVKPGPSFPGTLDTDPGPWGDEVAPPVSCAIYKGGYWRAARPGRPLFPRDSGPGPGAVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M129</accession>
    <name>A0A0M4M129_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF10</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173888.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100402"/>
    <dbReference type="KEGG" id="vg:26100402"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006882">
        <property type="entry name" value="Herpes_Orf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04797">
        <property type="entry name" value="Herpes_ORF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="433" mass="48147" checksum="6AEFBF105B4F300D" modified="2015-12-09" version="1">MACKPKDTNSIEYSMALVENVAIYDTNWKVVVTSKAFHVSNITPIKCNVGHSTTKLVTPFTIQGLVSEVLNYIGESSEKQLFNQLYHYIFVIEPFQQSENYKVINNIITCFKTPIGLFIETSATELKNDEVNFYISLYTPMLPSDLSASIANEHIENSVTLFTATSLKKSPFHGSTTMKGVAVRTSPDIYQMLFEWKDMPSFFGATFFKASSITLDMGTPEESLPLVAKSFNISRVGESMYKLKIQVHGSTQPPAVKISVCIGTRVHPSQVVMPSYITHETTQYHGWVIPLHTDYQIQLHPQETRHIQLNGYFAKGTNCTKQLVCLVGGANDNNKLLVHPSTWFPMTSPCILVTNPGNDVYIIPKGAVIALALPAIMDNRNGNCTLGRFIDFGGSPFFWSLSTISTQNLPQGDSRHSIKPLTTEEIRANLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M137</accession>
    <name>A0A0M4M137_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Major capsid protein</fullName>
            <shortName evidence="2">MCP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MCP</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae major capsid protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173900.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100414"/>
    <dbReference type="KEGG" id="vg:26100414"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039622">
        <property type="term" value="C:T=16 icosahedral viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04016">
        <property type="entry name" value="HSV_MCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000912">
        <property type="entry name" value="Herpes_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023233">
        <property type="entry name" value="Herpes_MCP_upper_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03122">
        <property type="entry name" value="Herpes_MCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00235">
        <property type="entry name" value="HSVCAPSIDMCP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103417">
        <property type="entry name" value="SSF103417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1147">T=16 icosahedral capsid protein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ALE14735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="1378" mass="153805" checksum="B01115EB85A4A6DA" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M145</accession>
    <name>A0A0M4M145_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF36</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173913.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100427"/>
    <dbReference type="KEGG" id="vg:26100427"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="435" mass="49441" checksum="6ED77C08D76F995D" modified="2015-12-09" version="1">MDKKTLTKMRTLQILSYHGSFKDSPMHQNKLQQFKESDNDGVLAMLLNLQCHLSIVEANPTSVFFKIPSRWKKCNHSTAKIKLALGSGSYGSVTAISKTECVKTFSTSKSFFHEMMVYDLVDIARMRSTYPQEGANIITMDGVCLKCKQLFFPRMQCNLYEYKHWTVENVSRLVRGFNGLLDAVLFLNEKCGFFHSDISPCNILVKQGFSQEEIGDLILSDLGLVSLHTGNRILHMGIKSSRGKVLYEMSSERGPFSVCKDLFKPACILFRCFMITADTRSQKAKFDCFLVDQQMARVIDVSSLALCLLYSIEQFMDVQKAAPTPNFYTICVVEDESPSYYMTCLIPRVVLLEFLSNLWHLKLDIGASSDGTFKHLNLCQQDKHNFQSWCNKAKKLYQKNLFYTSSILLSDPNLKFCLANLLSLDYFSPCGSQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M149</accession>
    <name>A0A0M4M149_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ORF50</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173925.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100439"/>
    <dbReference type="KEGG" id="vg:26100439"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004998">
        <property type="entry name" value="Herpes_TAF50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03326">
        <property type="entry name" value="Herpes_TAF50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0244">Early protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ALE14760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="524" mass="58725" checksum="139895BCEAD45832" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M157</accession>
    <name>A0A0M4M157_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ORF58</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">31286</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae BMRF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173938.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100452"/>
    <dbReference type="KEGG" id="vg:26100452"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006727">
        <property type="entry name" value="Herpes_BMRF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04633">
        <property type="entry name" value="Herpes_BMRF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ALE14773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="354" mass="40753" checksum="237BCE4170C25CA5" modified="2015-12-09" version="1">MKVVSEPCFLKTALASFLMGSLCSTMFLWCYIFVSLFTFTFFLSVMSHIYSEYILVLYAHLMIICFCDFSKKLNQILPTLGWISVIVTVLAFSFCYYNIIPDYTLPCIFIINAFLLSFWVPGTVEVIYLCQNVVHHYFEMGFYFAVIVYHGLVTIGAFETAIFLIPFCFFICVGVHAFCYFKNSIEYFNALDKRKAIFICGGDKYITFKFYEVLHLIFVEILTSLFLCTGMNIAIAATATYTTVFHVLGNYVYLMYFGTFCCGWISIPNRAISCTFTAANIVLIISLFMIEYDAYTSTFIFLISFFCYTSALNCELAILLKKLDRAVNAPKFFLFFRILCNFIVSVNLTLQKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M164</accession>
    <name>A0A0M4M164_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear egress protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NEC1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a heterohexameric complex with NEC2. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Host nucleus inner membrane</location>
        </subcellularLocation>
        <text evidence="3">Remains attached to the nucleus inner membrane through interaction with NEC2.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated at serine residues in the N-terminus. This phosphorylation regulates the localization within the inner nuclear membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae NEC1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173950.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100464"/>
    <dbReference type="KEGG" id="vg:26100464"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044201">
        <property type="term" value="C:host cell nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046765">
        <property type="term" value="P:viral budding from nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04023">
        <property type="entry name" value="HSV_NEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021152">
        <property type="entry name" value="Herpes_UL31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02718">
        <property type="entry name" value="Herpes_UL31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1043">Host membrane</keyword>
    <keyword evidence="1 3" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ALE14785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="309" mass="35373" checksum="4EBA8796044CA173" modified="2015-12-09" version="1">MPSTHHKFMSKISNMPPSYSKSTKSKKSQKSYKSNKSKSRRHLIHPYKSYTGMHCKTISISHEDFFYGISANKEFGRDFLREMDTPICTSSAICLPVDINQVAPGRCILLSPFGHTANMGFYCNYCSQTLNNSQICNFNPQPSNKSMYMGQNEELCSVALSFYNNAEKVVQHKGFYLSLLSNSMHLVKQSFKQPSLFYGYLVLKTFYQDIIPLFKEGEDKTITMYVTFKMDSLHIGETCLRLLTDNIKNYKIIIDCIKQVYVIKIFPQNPEEKTPTIPENSICDAVAALDFTDELKQELINSYELIAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M449</accession>
    <name>A0A0M4M449_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173874.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100388"/>
    <dbReference type="KEGG" id="vg:26100388"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="404" mass="44773" checksum="6BDF240B38F43D59" modified="2015-12-09" version="1">MDIDTFHKDTETHDEDGNLFFGPFLTVLQADMLRRRARWRKAALRKKMKLLEQDQVDPRDMKDDEGRPIFGPFISPKKYFLLKQRRTSMLSMRRRRLQQKHKAASNDEIHKDKDEDLTTLAGPSMELLNTLNLLIESGANEALSPAGCVIYEGGLLEGGPAWPSSSPGPLNQGLGPWVDEALSPAGCVIYEGGLLEGGPAWPSSSPGPLNQGLGPWVDDALSPAGCVIYEGGLLEGGPAWPSSSPGPLNQGLGPWVDDALSPAGCVIYEGGLLEGGPAWPSSSPDTLDKDNGHLNTAWPSLRSSEGGPSNSRLCNVQSKSPTNSDHDSQSDKDMPTFGPLLTLEAKKLYRKRYKRNWLRLHRQQQRKQQQENQFGPQISSKERALLRSRRRNLKRKKQRRAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M455</accession>
    <name>A0A0M4M455_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Envelope glycoprotein B</fullName>
            <shortName evidence="16">gB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gB</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans. Interacts with gH/gL heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Virion membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Host cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Host endosome membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Host Golgi apparatus membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="16">During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the herpesviridae glycoprotein B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173886.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0M4M455"/>
    <dbReference type="GeneID" id="26100400"/>
    <dbReference type="KEGG" id="vg:26100400"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044175">
        <property type="term" value="C:host cell endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044178">
        <property type="term" value="C:host cell Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019062">
        <property type="term" value="P:virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04032">
        <property type="entry name" value="HSV_GB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035377">
        <property type="entry name" value="Glycoprot_B_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035381">
        <property type="entry name" value="Glycoprot_B_PH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038631">
        <property type="entry name" value="Glycoprot_B_PH2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000234">
        <property type="entry name" value="Herpes_Glycoprot_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17416">
        <property type="entry name" value="Glycoprot_B_PH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17417">
        <property type="entry name" value="Glycoprot_B_PH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14 16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 16" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="11 16" id="KW-1039">Host endosome</keyword>
    <keyword evidence="6 16" id="KW-1040">Host Golgi apparatus</keyword>
    <keyword evidence="8 16" id="KW-1043">Host membrane</keyword>
    <keyword evidence="2 16" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 16" id="KW-1161">Viral attachment to host cell</keyword>
    <keyword evidence="9 16" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="7 16" id="KW-0946">Virion</keyword>
    <keyword evidence="15 16" id="KW-1160">Virus entry into host cell</keyword>
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        <location>
            <begin position="1"/>
            <end position="702"/>
        </location>
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        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="705"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="16">
        <location>
            <begin position="724"/>
            <end position="811"/>
        </location>
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    <feature type="domain" description="Glycoprot_B_PH1" evidence="18">
        <location>
            <begin position="91"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoprot_B_PH2" evidence="19">
        <location>
            <begin position="304"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in fusion and/or binding to host membrane" evidence="16">
        <location>
            <begin position="111"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Internalization motif" evidence="16">
        <location>
            <begin position="805"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="521"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022804"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022812"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_04032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17416"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17417"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ALE14721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="811" mass="92652" checksum="619E6AB67ECA95FB" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M463</accession>
    <name>A0A0M4M463_9GAMA</name>
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        <submittedName>
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        <name type="scientific">Felis catus gammaherpesvirus 1</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">31286</strain>
        </source>
    </reference>
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            <begin position="216"/>
            <end position="711"/>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF03043"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ALE14734.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="732" mass="84450" checksum="9AEE9A34F2BAF02E" modified="2015-12-09" version="1"> </sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
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                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">31286</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="148" mass="17221" checksum="3C91A4DD9560851E" modified="2015-12-09" version="1">MALSNNLSKNLLSKYLEAEINKKTSISTFDRFGEKSVLFQKQFQDTKTSIKGYKTLKQKLNVESAIETINNTAESTYQEYLLLSHYNLKKVREVEKLCDKVRDLKEDFDFELQDLIHRDDGQENTHEDEDVTDTILSWKLQGLPDAPK</sequence>
</entry>
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        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
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                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
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                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">31286</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000152314">
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        <location>
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            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ALE14759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="468" mass="53574" checksum="DA6BA14624D312CB" modified="2015-12-09" version="1">MEPQLFLPVPGVSSENLNLWLGHLNTFIHYGKLQAALSNLKTLFRENEFGFLASLVILHTKFCESLKYKHKSSLIEDAKKIRETAILLYKKLKDHEHDSDIQIIFEDCKQRLCLILEVECGCVECIHTINQLTKTQQASKPPCLTPHDKHTSSYKFLTWVHQSVVLNLDVNLLESEVDQLYEQCYPFSDFPPSLHGELVLLTSCLNFTLLFNLLNYFITLELELLETCLQQLQAKLNLNTDNLTSCVECLLGHAKELQLDSHVYEINCLHLDNSSKLLKQKLAQPISSLQESTLSKILGLKPSHSCGVQPRVWCSSKNSQSKPQNQFAEVCQVLSAFRLMHPNPLQSASTHKFKASPQIVIPPRDELHYYSDDEDEEPPLLISDDEEDSDEEHQELTSDEEDGINCNFKLLISDEEDESVDTQQLSFIYDKNKGETGVNKTHIKTTQKNESEDDNDLRLNFGYYRENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M485</accession>
    <name>A0A0M4M485_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF57</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="26100450"/>
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    <dbReference type="Proteomes" id="UP000152314">
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    <dbReference type="GO" id="GO:0006355">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ICP27-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="487" mass="54655" checksum="DE1D4901784BD48B" modified="2015-12-09" version="1">MAQAMLLDEDVMKTLLEDLPEFEEDGCDIDLTTKAIEAFNAIAASVNNNQDQTVSYVESHDTVEKSAQQTGGLVDYEMSEEASNSSTSSTESEDEQPQKKTAPRKFKTTPNKDQHPIVLQRAFSGKSKEVRTSTYTSDVSHLNVYSDPQDKWARQGAHMSRKRTREPDYCKSKVEKIYYNNSGNKKMMGCNTFKRNSYIQHCFQKMRLEPNNVRFTKDCSMFLDGVTDNIFIRAPKTVQNNSVVFQSENLNDRYILKLAEMGMVNKSLECKIAPLELLQVNFHAIRAFATQSKNVAAYINLRKDTMACGTLQTLALFLEETMQYAQLCVENNIHLSDSADIILSTAPFLSHQIMFKLKNILCCVEKDRNCSAVCRQITYLICSCNRLVDAGALLQEVKIMSNLQLLIVCCLTVPSLYQAHLFDNLEILDYFKEILDFYKPGTISGICHSLYAKQPCSGPKSAECAGTLAATIGSNVSTQGLLFFPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M493</accession>
    <name>A0A0M4M493_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Packaging protein UL32</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the herpesviridae UL32 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173949.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100463"/>
    <dbReference type="KEGG" id="vg:26100463"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002597">
        <property type="entry name" value="Herpes_env"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01673">
        <property type="entry name" value="Herpes_env"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ALE14784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="449" mass="50556" checksum="DB038E567C56B694" modified="2015-12-09" version="1">MEGCYRPWNVNTILKHSVALQTLLQNSYQPGEPETALNSPVLTGTYNSLSNSSSCKVCQIIYSLISKYNPSISFYEDYACLCFYTLYAPKSWSATFMVAADLLELFDKHFSQWEDFKALYTPGSILGIDLNLHFFIQKCFRKIKTDAILDFANLNFLKVEFLRGCLVGSIPHIFCFKSTWNASRTICSTCINPASTSLHQNIDKVFNNPQLTPKCSFLSIILNIWSQSTLLSEQHKQLTDKGLNLWSKAPNDGDVSQGPCLLSHSLQLKIQGCTSSICLLCECLASHSDAALTLQFLKEDIITSAENNIKLIDRIIFLLKDETSMKYITDNLLLQVIRGCSPQEIHKHLFCDPRCLVNTISTSSNILFKIPSDSQLQKLKATLALGIHLDSNNIFDCENLDTLITLFKCIQICKVGKTTFLEIIKHLNSALKKHNILTVHAFNTSQIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M4G1</accession>
    <name>A0A0M4M4G1_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F12</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173883.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100397"/>
    <dbReference type="KEGG" id="vg:26100397"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="188" mass="22286" checksum="5200D89F006FDDC3" modified="2015-12-09" version="1">MSSYVLLEDAKNFEVYSISHMFYRVMMAVSNPRGHGLLLNPQEAMMVWIIQEQRGSDGLEPLRRYVESTFSDQKTNEIDSIEKLLTVIRGFYHHGKYNITKVTAILSYSACFTQCIFGGDPQYTMRVASKLAEFILYEWPGQIESISRELYNFDLVLWVYFHIKQRILLWKHLWNYHLRNRNQNLNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M4G8</accession>
    <name>A0A0M4M4G8_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Capsid vertex component 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CVC2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae CVC2 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173895.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100409"/>
    <dbReference type="KEGG" id="vg:26100409"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019072">
        <property type="term" value="P:viral genome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075732">
        <property type="term" value="P:viral penetration into host nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04025">
        <property type="entry name" value="HSV_CVC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002493">
        <property type="entry name" value="Herpes_UL25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01499">
        <property type="entry name" value="Herpes_UL25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="2" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="2" id="KW-1163">Viral penetration into host nucleus</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <keyword evidence="2" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="region of interest" description="Interaction with major capsid protein/MCP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ALE14730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="539" mass="61062" checksum="2899018A7626860D" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M4H6</accession>
    <name>A0A0M4M4H6_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF31</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae UL92 family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173908.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100422"/>
    <dbReference type="KEGG" id="vg:26100422"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004289">
        <property type="entry name" value="Herpes_UL92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03048">
        <property type="entry name" value="Herpes_UL92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="225" mass="25939" checksum="E56D5AC968EEE1C3" modified="2015-12-09" version="1">MHQRSEFYTGCRPKCRWPESCTLDRVNYTICGYHNISCIFRCCVCNHYHICDGGDECVVINTGESLVCMLTGSCLTNEIQDYKNLVVRAHKALEKKPDGYTLQCVLQAVKRDIVNFFSNAESVLNEVKNVILLNNETLTHDIEKLIDLTYSETHQLFSTCEYGYNIICSMYIQIIISIYSSKTIYNNLLFKCTKNKKYDTILKRMRELWMSTLTTGSSVLKHVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M4I2</accession>
    <name>A0A0M4M4I2_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication helicase</fullName>
            <ecNumber evidence="4">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HELI</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the primase and the primase-associated factor to form the helicase-primase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the herpesviridae helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="4"/>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173920.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100434"/>
    <dbReference type="KEGG" id="vg:26100434"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039686">
        <property type="term" value="P:bidirectional double-stranded viral DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04030">
        <property type="entry name" value="HSV_HELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034711">
        <property type="entry name" value="HSV_HELI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Herpes_Helicase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ALE14755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="781" mass="88286" checksum="23BEBB5FE144FCEA" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M4I9</accession>
    <name>A0A0M4M4I9_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="3">dUTPase</shortName>
            <ecNumber evidence="3">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DUT</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="3"/>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173933.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100447"/>
    <dbReference type="KEGG" id="vg:26100447"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046080">
        <property type="term" value="P:dUTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04031">
        <property type="entry name" value="HSV_DUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034745">
        <property type="entry name" value="HSV_DUT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="127"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ALE14768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="286" mass="31820" checksum="5F4EA9AE36C8AC76" modified="2015-12-09" version="1">MAPEVYKPRLVYNFFANNFAPISDCYELTLTNTQNILIEPFTPTIVPIGIKIIKCPKNLGCFLYGHSNKAVCCHLGVIDPGYTGELKLIIWSTTASAITILAKELQVSIVPFNYITPNLSSQNLLSHPHYLNDVGYDLHLPEDITIFPMSSKRIYIFKHPPHVSKLYTAVVLGRSGLAINGTIVTATKWTSNFLEIKLTNYSNSLVYYAKGTKICQITFIHNKHLLSPNTHTTKSCTIGTSVFSGSKICFVEDKNVNQNENYSCVPTQKIECQQVRGDSGFGSSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M4J5</accession>
    <name>A0A0M4M4J5_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small capsomere-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SCP</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the major capsid protein and small capsomere-interacting protein/SCP assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the major capsid protein/MCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae small capsomere-interacting protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173945.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100459"/>
    <dbReference type="KEGG" id="vg:26100459"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04022">
        <property type="entry name" value="HSV_SCP_gammahv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009299">
        <property type="entry name" value="Herpes_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06112">
        <property type="entry name" value="Herpes_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ALE14780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="141" mass="16006" checksum="B02A9B911273B7D5" modified="2015-12-09" version="1">MSREQLRDPIIQDKLEDLNIQQHLIKQVQALPKSNKTDQEYAKAQRLYLTFLLTQQFFDNITNQNLGVRRKKHIEAYRKLQQGSQQIPQSISSSPFVQAAIYNGEPPKSTGSSISTLFSEDHSTESGDLVAKRTTSGSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4M4K2</accession>
    <name>A0A0M4M4K2_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F26</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173958.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100472"/>
    <dbReference type="KEGG" id="vg:26100472"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="133" mass="14617" checksum="8BC0393C90491BE8" modified="2015-12-09" version="1">MIAGASIWLHVLLINILGKTVHASSSVITSSETTKAVPTTVTVTSVTSGLGSSLTSQNHQTNTVTTVNFNSQLLKSTDLVMVMLLVTIAGLFLLIMSGVIITDCYKNRNRRYQRVPLIPLRNYPNQRNRMWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MD83</accession>
    <name>A0A0M4MD83_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F7</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173878.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100392"/>
    <dbReference type="KEGG" id="vg:26100392"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="SSF47986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="1">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="1">
        <location>
            <begin position="104"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="182" mass="21829" checksum="FD0206D81ACDACEF" modified="2015-12-09" version="1">MWAYGFLILYLMEPTGLLEIYDALDENEIQWCRYLCTGIVPIIDHCPDLKEVLYHLACVYGQRFISELLYSIMRYDLLHKCYGFKVRGYAKHLEALYWVCHIPRHRVVFFWLEQNLNDDELRKLFFFYSNVINRKVYRMLDFVTTLEKEDSLENALQILLEGLKCIGRRDIVRSLQNVNILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MD91</accession>
    <name>A0A0M4MD91_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F14</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173890.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100404"/>
    <dbReference type="KEGG" id="vg:26100404"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="137" mass="16456" checksum="0C10F8D6543A5B48" modified="2015-12-09" version="1">MLFQSFLKLERTKEDTEAIIQEDTGPGKARHELWFTPYPFFMFVLFLMSVMLFLYGFMIYEKAYNTPSWVLRRIYIQSDNVNWTCFKKPWFLSQTNQTVVNINFTQLLNNTNLSMCFLLRMYTEGSPQKKYFCTKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MD99</accession>
    <name>A0A0M4MD99_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F16</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173903.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100417"/>
    <dbReference type="KEGG" id="vg:26100417"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="148" mass="17253" checksum="7C525652576B4B30" modified="2015-12-09" version="1">MKALFIGCLLFCVGTQSESERQARIDLLKTPLPAAEEALPLLCIKRFVWDVTWTENFFCEAVQSFERCTPPLTWRVLRLLQKLCYRETELILIPSRRIEVVGLLRKIVQKLCLDQIGQVIKQSTNHLQYVVFVCTGFDLSTCKCRRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MDA7</accession>
    <name>A0A0M4MDA7_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytoplasmic envelopment protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Virion membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Host cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Host Golgi apparatus membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="10">Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173915.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100429"/>
    <dbReference type="KEGG" id="vg:26100429"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044178">
        <property type="term" value="C:host cell Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046760">
        <property type="term" value="P:viral budding from Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04042">
        <property type="entry name" value="HSV_CEP3_gammahv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024360">
        <property type="entry name" value="Herpesvirus_UL11_homo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10813">
        <property type="entry name" value="DUF2733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="5 10" id="KW-1040">Host Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1043">Host membrane</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="2 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0946">Virion</keyword>
    <keyword evidence="3 10" id="KW-0920">Virion tegument</keyword>
    <feature type="initiator methionine" description="Removed; by host" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-myristoyl glycine; by host" evidence="10">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ALE14750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="67" mass="7573" checksum="451881CA1926EBB6" modified="2015-12-09" version="1">MGIICSICRRRHYTIESLSGEQIDTQTEFDELGESDELLSETTDPPPTPSTKTSKKKKIKKKVVFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MDB5</accession>
    <name>A0A0M4MDB5_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F20</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173928.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100442"/>
    <dbReference type="KEGG" id="vg:26100442"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="154" mass="17503" checksum="2F797891C1A12A0E" modified="2015-12-09" version="1">MFYFFVFQIAAFRESQIDIMRGKLQNTREENIKLKKLITAMQMQYKTANQQLPAPQPQPIYTVAFASQPGTQDKFFCLPTHQFVTSQAPATILTTPQQQFVTQQQQFMTPHQQFILPTSGPVTSFLQEPLVQLPPTSNATTTTPLKPILPKPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MDC2</accession>
    <name>A0A0M4MDC2_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonucleoside-diphosphate reductase small subunit</fullName>
            <ecNumber evidence="12">1.17.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ribonucleotide reductase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RIR2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Host membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="12"/>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173940.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100454"/>
    <dbReference type="KEGG" id="vg:26100454"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033644">
        <property type="term" value="C:host cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009186">
        <property type="term" value="P:deoxyribonucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04028">
        <property type="entry name" value="HSV_RIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034715">
        <property type="entry name" value="HSV_RIR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 12" id="KW-1043">Host membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ALE14775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="312" mass="36483" checksum="167E89ADE40B176A" modified="2015-12-09" version="1">MNCTKSSVDFVNQFLYTCDHEGFLNLTQETWQNRWFPNQISLSSDVTTFHLLTKTEHDFYKFLFSFLGFSEKLVNFNIEDLIKEFNSHDVAHYYTEQMAMENIHGKVYANILNMFFNNNMGELKKYAITILDDNALKDKLHWLHKRVINAKTRAEKVLLFLLIEGIFFISSFYCIALLRIKGVMNGVCLANDYISRDEWIHTRAAALLYNTMIHDREKPTSEWIYNLFQEAVDVETAFIERKGCHLSSEKLLDINQFLQATADRILKSINLRPLYNVRPPPDCPLVYIGCIKNVNFFERESSDYTTAVADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MDC9</accession>
    <name>A0A0M4MDC9_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F24</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173953.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100467"/>
    <dbReference type="KEGG" id="vg:26100467"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="81" mass="9767" checksum="F041A34E613E4E33" modified="2015-12-09" version="1">MTVYINCQKSKPIFILPKLPSDLPLDETFCTQPLCIYLKHRQEHLNLILFFHSYSKKGRLKRRLKTGYMRCSRRSKRKTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MPT9</accession>
    <name>A0A0M4MPT9_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F9</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173880.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0M4MPT9"/>
    <dbReference type="GeneID" id="26100394"/>
    <dbReference type="KEGG" id="vg:26100394"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="PTHR11256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="SSF56854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="BCL" evidence="2">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ALE14715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="189" mass="21268" checksum="3F1F8CFF827155E7" modified="2015-12-09" version="1">MEQNQDEHADVLAAFIGEFYGFYGLPFSGDFGSTECHVVGLVLADVAYQATTQLQGFEHLFQQMLQMDLDEAVILFQEVAQELFTEINCGRIIIFLSFSGLLLVKCVTQRKILLERCLHTSILTLLRGVLGNWLEQNGGYDALLNNLVQNHPLVDLTTSPSYRFLTYFFIFLCGAAVAALFSILLMKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MPU7</accession>
    <name>A0A0M4MPU7_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF17.5</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173893.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100407"/>
    <dbReference type="KEGG" id="vg:26100407"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="287" mass="32481" checksum="0173861FBD3BD6CD" modified="2015-12-09" version="1">MATNARANTPTSDDLISIPRGAFMSLLQTNLDAKHPTTLHYPHIPSSDNGGQKMQFIPRQSMGYNASNIPYPSQIPPYYIPWQDMDPHGFNTMGFTTNHTYIPVPFPSRPNKRKRESDMEDWVTFPGEEIYRSKELQDLSKTITELQREIKELKNNSMGKIGVKTELQTVPPVNCQVIPQHGHYFPSQPFPPAYFHTQGNPLYPFYPPKNINTSNSPIINQGVVEQRNHESVPKSSENTKQSNTQLENKHEESGTSTQSKTTVDASMPPVSTVNPLQKLFCEELLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MPV3</accession>
    <name>A0A0M4MPV3_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F18</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">31286</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173905.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100419"/>
    <dbReference type="KEGG" id="vg:26100419"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043657">
        <property type="term" value="C:host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075733">
        <property type="term" value="P:intracellular transport of virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010077">
        <property type="entry name" value="Herpes_virus_tegument"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01739">
        <property type="entry name" value="tegu_FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <keyword evidence="2" id="KW-0920">Virion tegument</keyword>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="803"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ALE14740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141118" checksum="138C55E58273D20F" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MPW0</accession>
    <name>A0A0M4MPW0_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytoplasmic envelopment protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae cytoplasmic envelopment protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173918.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100432"/>
    <dbReference type="KEGG" id="vg:26100432"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044177">
        <property type="term" value="C:host cell Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04038">
        <property type="entry name" value="HSV_CEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002600">
        <property type="entry name" value="Herpes_UL7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01677">
        <property type="entry name" value="Herpes_UL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="1" id="KW-1040">Host Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <keyword evidence="1" id="KW-0920">Virion tegument</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="268" mass="30808" checksum="C1318DB26BD468C5" modified="2015-12-09" version="1">MDSVIRTIVGSKKDSLYQDMEYMFTFALPRMVLEVNRSNNVCIASNSETFFQKEELDVAALAKYVRQKTISPTYRGFIMTCLLETEDMVEKINLYPHVFKERVFIYTPVHNSAIELCVLISILENFTSPTLVSILSILQRARFIYTKYKSKDTAFLLNGIEALAATTINYFELANNDDHTTQPGLLLYKLHKAIEGGSVESKGLLKPIFLYSFKMDGKENTLNSQSICQSFNIFYSETIFTHHFRCPQVVSIYKDKCLEDKPRVQIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MPW8</accession>
    <name>A0A0M4MPW8_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F21</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173930.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100444"/>
    <dbReference type="KEGG" id="vg:26100444"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="453" mass="50476" checksum="4299B8BD59E923E6" modified="2015-12-09" version="1">MDLLCNVTLYHTQHIWTVPYLTWVFLLGLQPHSLNVSVQNYNIQIFIVLGDTNNSEVHSVSITKLKQLSQSFTLQSKFIDDCIFTVNLIKLDNHYAILLKASPDMYTSLYAVIIKIEDPFGVVWCQMLPFKPLEKKPYVQILKSVSAPKAILYDKILLTAILKEVPTDLHFNLNVSFDQKHFDNLTLKNFTYITANKLNALILRPQKGISIMFVQTVTNIPTFYKFLSVSIYTDTSKQEYLSECTLKNSKMSKQIPMSNIPGTMVLTYNSSIHKANVLCFDKFDSVFQVKSMIIQTSRKRHKRSSSNSTITPSMSTNTNNSSVTFIDTTSSLASTPTAQTSSLTTTIITANTSSQTSAYAPTTSTQTSSSQTSSSIITSTVTENKSSHSYSTTTNTSHSSMVITENASQITSSVVTPTLTTTQSNTHQTKPLTSSTMNVVIVINMHHINIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MPX1</accession>
    <name>A0A0M4MPX1_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF63</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173943.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100457"/>
    <dbReference type="KEGG" id="vg:26100457"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007611">
        <property type="entry name" value="Herpes_U30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04523">
        <property type="entry name" value="Herpes_U30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="916" mass="105496" checksum="502C8CE7B90A4699" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MPX9</accession>
    <name>A0A0M4MPX9_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ORF74</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173955.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100469"/>
    <dbReference type="KEGG" id="vg:26100469"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F1_2" evidence="5">
        <location>
            <begin position="66"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ALE14790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="341" mass="39020" checksum="5FA6A0DD203D4379" modified="2015-12-09" version="1">MQSYLNVGADELASIFGDYNDSNNYNYSEYNNGDEAHTKPCYSTRWVSLGFKFWFLIFVLCCACIGNIWLLFQIFRSRFYRICHVLLCALCCNALVGCAYILFHMLEVFASVLSSWFCKIEALLQGFYMLFGILIICCMCFDTWVAIWFPSFKSREPVLTGFKCCVVIAALAAIMSVPKVLYVGVLRVSTVSTSSKTPPHNGQCYVMKGLETSQLLRVFNITSSVTGFLLPLLFLLLFYGMCLYKLLHSKFKARIAAMRTMICIIFFFLLFYGPMYCVMMYDTLMRLGYVPDTCTSRTWIDLLKSCLECFSTMFIVIIPIINACFSSQLRQKLLRSPTISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MS25</accession>
    <name>A0A0M4MS25_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173873.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100387"/>
    <dbReference type="KEGG" id="vg:26100387"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="251" mass="27309" checksum="9D4CBABBCE545805" modified="2015-12-09" version="1">MGGGKKYGACFQKIGCGRIHINAGSTISTSEVSSHEGLPATSQWEGLPAHRQTRAPRVGLWTSPTTQSPTPAQWEGLPAHRQTRAPRVGLWTSPTTQSPTPAQWEGLPAHRQTRAPRVGLWTSPTTQSPTFAREVQPPHLKVHLIIHPFTGNRTGKNPFQLNATTTTPLVCLDPVVYKENTMWVFILLQVPVTSPWGQPAAHTVPTVCMEGPPTAFSCLRAGGLRQALQLTQVFNLMPLLPPDHLGDISSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MS34</accession>
    <name>A0A0M4MS34_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tripartite terminase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TRM1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with TRM2 and TRM3 to form the tripartite terminase complex. Interacts with portal protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Host nucleus</location>
        </subcellularLocation>
        <text evidence="4">Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the herpesviridae TRM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173885.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100399"/>
    <dbReference type="KEGG" id="vg:26100399"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019073">
        <property type="term" value="P:viral DNA genome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04014">
        <property type="entry name" value="HSV_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000501">
        <property type="entry name" value="UL28/UL56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01366">
        <property type="entry name" value="PRTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="2 4" id="KW-0426">Late protein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="1 4" id="KW-1188">Viral release from host cell</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="621"/>
            <end position="628"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ALE14720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="690" mass="79146" checksum="0522C46265A49821" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MS42</accession>
    <name>A0A0M4MS42_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Envelope glycoprotein H</fullName>
            <shortName evidence="17">gH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">gH</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Virion membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Host cell membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Host endosome membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="17">During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="PTM">
        <text evidence="17">N-glycosylated, O-glycosylated, and sialylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the herpesviridae glycoprotein H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173898.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100412"/>
    <dbReference type="KEGG" id="vg:26100412"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044175">
        <property type="term" value="C:host cell endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019064">
        <property type="term" value="P:fusion of virus membrane with host plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04033">
        <property type="entry name" value="HSV_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003493">
        <property type="entry name" value="Herpes_gH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035305">
        <property type="entry name" value="Herpes_glycoH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038172">
        <property type="entry name" value="Herpes_glycoH_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17488">
        <property type="entry name" value="Herpes_glycoH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-1169">Fusion of virus membrane with host cell membrane</keyword>
    <keyword evidence="2 17" id="KW-1168">Fusion of virus membrane with host membrane</keyword>
    <keyword evidence="15 17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 17" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="13 17" id="KW-1039">Host endosome</keyword>
    <keyword evidence="9 17" id="KW-1043">Host membrane</keyword>
    <keyword evidence="14 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 17" id="KW-0730">Sialic acid</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 17" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="5 17" id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0946">Virion</keyword>
    <keyword evidence="16 17" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="topological domain" description="Virion surface" evidence="17">
        <location>
            <begin position="1"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="17">
        <location>
            <begin position="757"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Herpes_glycoH_C" evidence="19">
        <location>
            <begin position="583"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ALE14733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="762" mass="87815" checksum="79F8070D71195211" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MS49</accession>
    <name>A0A0M4MS49_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Cytoplasmic envelopment protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Interacts with cytoplasmic envelopment protein 3 and with the capsid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173910.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100424"/>
    <dbReference type="KEGG" id="vg:26100424"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04039">
        <property type="entry name" value="HSV_CEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004286">
        <property type="entry name" value="Herpes_UL16/UL94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03044">
        <property type="entry name" value="Herpes_UL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="1" id="KW-0426">Late protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0946">Virion</keyword>
    <keyword evidence="1 2" id="KW-0920">Virion tegument</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ALE14745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="335" mass="38555" checksum="AEB084BB7F1D7C8F" modified="2015-12-09" version="1">MDKHYYEDLRRFLNRECLWCKYDLCSPYVKMYYASTAISPNFRPTELQELEKTYVLNVSIIFLKPKKQPTYVTVFINEVFIACCVPDFISIKAVPGEHDMFLMYLGPFYKPPSDTKIPALIKIEAFEDGIIPLKSDIWKTSSLVSTKQLQTEFKSWTFTTIGKCVWYGRGSLFQFFLSMEYMVCCPQFKEFPSFGRLVNLVTRCDDKNCVPCYGLKVHVNVKGGYTPPFYNGDSISCPCVLSCAALKSDIVPITGHRNILTLFFGPEVHNEIISLKFKPSKRPIEITDLCVGITGDGQEVQIDEKAWQLLRMSDFFTRACIYGCQILKRRCLNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MS57</accession>
    <name>A0A0M4MS57_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Envelope glycoprotein L</fullName>
            <shortName evidence="10">gL</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gL</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Virion membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Host cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Host Golgi apparatus</location>
            <location evidence="10">Host trans-Golgi network</location>
        </subcellularLocation>
        <text evidence="10">gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the herpesviridae glycoprotein L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173923.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100437"/>
    <dbReference type="KEGG" id="vg:26100437"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044177">
        <property type="term" value="C:host cell Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019064">
        <property type="term" value="P:fusion of virus membrane with host plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04034">
        <property type="entry name" value="HSV_GL_alphagamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020175">
        <property type="entry name" value="Herpes_gL_rhadinovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038313">
        <property type="entry name" value="Herpes_gL_rhadinovirus_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034708">
        <property type="entry name" value="HSV_GL_alphagamma"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11108">
        <property type="entry name" value="Phage_glycop_gL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1169">Fusion of virus membrane with host cell membrane</keyword>
    <keyword evidence="1 10" id="KW-1168">Fusion of virus membrane with host membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="4 10" id="KW-1040">Host Golgi apparatus</keyword>
    <keyword evidence="6 10" id="KW-1043">Host membrane</keyword>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 10" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="2 10" id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0946">Virion</keyword>
    <keyword evidence="9 10" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ALE14758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="174" mass="20071" checksum="357BFBE888E5A409" modified="2015-12-09" version="1">MNYYWFIFVLYMFYPVIYCSPTLPCCDINVKDVSKMASVFEASKIVLTLPQTCQNVNVATIHVKPQNTSVTKTICVNGFNVMSFLLHLFQRISYNHPQALNYTFISYLEKYKEQFAHNFSIQTANSSRFSLKNISSKKGKNKKKKQNTTPNKQKLQVLTVDTETINSNTFTYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MS63</accession>
    <name>A0A0M4MS63_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase</fullName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the helicase and the primase-associated factor to form the helicase-primase factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Requires the presence of the primase associated factor to properly localize in the host cell nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae DNA primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173935.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100449"/>
    <dbReference type="KEGG" id="vg:26100449"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039686">
        <property type="term" value="P:bidirectional double-stranded viral DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04011">
        <property type="entry name" value="HSV_PRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033685">
        <property type="entry name" value="HSV_PRIM"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="site" description="Essential for primase activity" evidence="1">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="site" description="Essential for primase activity" evidence="1">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="853" mass="97828" checksum="5D02A1BA9FF65BC4" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M4MS71</accession>
    <name>A0A0M4MS71_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tripartite terminase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRM2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with TRM1 and TRM3 to form the tripartite terminase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae TRM2 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173948.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100462"/>
    <dbReference type="KEGG" id="vg:26100462"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019073">
        <property type="term" value="P:viral DNA genome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04015">
        <property type="entry name" value="HSV_TRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005208">
        <property type="entry name" value="Herpes_TT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03581">
        <property type="entry name" value="Herpes_UL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="1" id="KW-1188">Viral release from host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="92" mass="10796" checksum="02AD0A217D8B8BE0" modified="2015-12-09" version="1">MSQYLNSPHLYENLICFESLLPEDIKIFVPTVYTKLNLLNYCQYLKVFLVYNHLAGSIHKCSHQNIIFTKLEIIKQVISRIIETDSVYSNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5KXP1</accession>
    <name>A0A0M5KXP1_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF20</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173896.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100410"/>
    <dbReference type="KEGG" id="vg:26100410"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002580">
        <property type="entry name" value="Herpes_UL24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01646">
        <property type="entry name" value="Herpes_UL24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="282" mass="32340" checksum="D65638278D357C0B" modified="2015-12-09" version="1">MTVLPEQISKDILSVLPASRKAAGKKAHLKIYKKLLGYRNTNSLLKFLSITHPCPNKCTFKLFIEVSLGNRISDCVLLLTCGESRICYVIELKTCISKQTNMSRDIRQAQKSQGLHQLLDAVRFVQNSLPLGRQKWNLIPHLLFKCQNSLKTIYQESPAFMTNLAFSNHQKLSQFFTQREDLGLKKRLSSHLHVLKHKTTQSLCDKNPGTKQSITHKQRLIDRNKKVCFKIQKARLGATPFSGKKRPIEGRIGSFSTRSYQYNPRRAPKTRYPRKCYSASFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5KXP2</accession>
    <name>A0A0M5KXP2_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DBP</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomers. Forms double-helical filaments necessary for the formation of replication compartments within the host nucleus. Interacts with the origin-binding protein. Interacts with the helicase primase complex; this interaction stimulates primer synthesis activity of the helicase-primase complex. Interacts with the DNA polymerase. Interacts with the alkaline exonuclease; this interaction increases its nuclease processivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Host nucleus</location>
        </subcellularLocation>
        <text evidence="4">In the absence of DNA replication, found in the nuclear framework-associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the herpesviridae major DNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173884.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100398"/>
    <dbReference type="KEGG" id="vg:26100398"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039686">
        <property type="term" value="P:bidirectional double-stranded viral DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04007">
        <property type="entry name" value="HSV_DNBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035989">
        <property type="entry name" value="DBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043031">
        <property type="entry name" value="Viral_ssDBP_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000635">
        <property type="entry name" value="Viral_ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00747">
        <property type="entry name" value="Viral_DNA_bp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118208">
        <property type="entry name" value="SSF118208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Required for nuclear localization" evidence="4">
        <location>
            <begin position="1122"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ALE14719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="1137" mass="128964" checksum="034EE07ACC870933" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5KXP4</accession>
    <name>A0A0M5KXP4_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ORF32</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173909.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100423"/>
    <dbReference type="KEGG" id="vg:26100423"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007640">
        <property type="entry name" value="UL17-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04559">
        <property type="entry name" value="Herpes_UL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3" id="KW-0426">Late protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="4" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ALE14744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="458" mass="52614" checksum="D861437832C18942" modified="2015-12-09" version="1">MDVHINNWKFCSKTCDLLIHVFLPSKFLSDNNISVDCESLMFYVQTRYTQTLIPSKYVHVWGQKFTFNISKKSQIMGLAISLPICLTSHNQYNPWNITTLKIVNRLTGVKQFVHFFHLTLLQSFMSTRDILIKKLHQNETEVLPQETMNEPLDAIFKTVAKKSHLDEPLSPLKFLSGLLKSESVFRHHQALENPGDVRGLNKPIYVSPKQIPPLRLSDSRPVYIKKHALNAKDLNMEWSCTTNIISKSKFFVCVYDKISDITTQYHSMLDNIPLEQLTPMSPINALLNNISFLESKQYQCVDSLERTCLNQNLTILQKLAINFDKSSFTTEALQDHFLEACFIMRQCISEQCAWIEAAIAKQNNKNGIWVDFFQLWGQDHNLGVYFSSLCDKNISDEEMWVHLLTNNCFTSLVTKCTHACLVVVPTLICYLLLPGGFVIKGSYTLSYNDLLVVNERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5KXP8</accession>
    <name>A0A0M5KXP8_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Envelope glycoprotein M</fullName>
            <shortName evidence="3">gM</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gM</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Virion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host Golgi apparatus</location>
            <location evidence="3">Host trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host nucleus inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="3">During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae glycoprotein M family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173916.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100430"/>
    <dbReference type="KEGG" id="vg:26100430"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044175">
        <property type="term" value="C:host cell endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044178">
        <property type="term" value="C:host cell Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044201">
        <property type="term" value="C:host cell nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04035">
        <property type="entry name" value="HSV_GM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000785">
        <property type="entry name" value="Herpes_glycop_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01528">
        <property type="entry name" value="Herpes_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00333">
        <property type="entry name" value="HSVINTEGRLMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-1039">Host endosome</keyword>
    <keyword evidence="3" id="KW-1040">Host Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-1043">Host membrane</keyword>
    <keyword evidence="3" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with gN)" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ALE14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="374" mass="42726" checksum="0FA89E8CE603CEF0" modified="2015-12-09" version="1">MESSKSDKFIYKVWLKLLVLYFIMFGLSTTVPIAAMYPKLGFPCYFNALVNYTAVNLTQRNVAKHLTPTFFLEAYEMFAYITISFLIDCVSAIYYTMGACSVFLAKKKHISGLTSLSQWIQLVGTPTQVFLGILRMWTIQLFIHTLSYKHIYLAAFVYTFHFLMSCCHVQCHICKSCKPWNLKVIEQQIPEKTILSILVFYVKPIIINAQLFCLALELLVYSLSLFMAIGNSFYVLVSDIVFGSINMYLGGALIFFVTTEILYVKFIQVLVGFHLGVVTAAIILALPLLRYEHIFVAAKIQSIISINIICIPMLAVIAICVRFLRIFYCFTTPPTLYAPLRRNHSLFKKKKKREKQASQGPIILEETSTDEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5KXQ1</accession>
    <name>A0A0M5KXQ1_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF66</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173946.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100460"/>
    <dbReference type="KEGG" id="vg:26100460"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004339">
        <property type="entry name" value="UL49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03117">
        <property type="entry name" value="Herpes_UL49_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="446" mass="50498" checksum="DDEAFDDBFB563FC6" modified="2015-12-09" version="1">MVWSKVQLDNSVNFSEGIDRRCFCFDCDTAFCDVMIVDYTEFCQYIVYGSQFWTLKDVPTWITTLDKAVDLNSYILSMLSLTEPIEQDLDLLTKGRVAKYILHTYALILLQVLSIDDIFAMSVHNVVAQFPSNILLTKSFKMAISQLNMEIGLNNLKTPWVQCHIKLGCIFTNSKKKPKMSSLASSSLSLCVPPPSNRSEIKTGFIQDLPQSSYSLFTSREERLYSALKAHVDGVPCGNPFNSLVRVLAFEGIIRSRYSILPIKIDNMSSILHNMYNKILAYNLLWPCFSIPVVSKFLLPESIPQPSNCIVVCRECGHCLNFGKGKFKKLTFRPNHKFYCRDQKEKHFSICASTGRIYCSFCGSADVKPFPLKFHKKGYQYIRVVMAGNCSIASECGDQVFDVIVPCMGEVQCSSVLLKTTSLISLLYLTSDTFKFVCDKCEHKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5KYM8</accession>
    <name>A0A0M5KYM8_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uracil-DNA glycosylase</fullName>
            <shortName evidence="6">UDG</shortName>
            <ecNumber evidence="6">3.2.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UNG</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173922.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100436"/>
    <dbReference type="KEGG" id="vg:26100436"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:base-excision repair"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
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        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ung"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 6" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="8">
        <location>
            <begin position="73"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_04046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ALE14757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="253" mass="29046" checksum="3F61915DEB71B2BB" modified="2015-12-09" version="1">MDDWLKKHVWGAQNYENDNITEDKLLLTPEWLYFLELSPFLKKKLHRLIETIAKLSLTTTIYPPNEKIMYWSKICNPIDIKVIILGQDPYHGGQATGLAFSVLREYPIPPSLKNIYQEISRTDSAFITPTHGCLDGWGKQGVLLLNTVLTVEQGKPGSHSDLGWVWFTNYVINKLSEKLYNCVFMLWGSKAIEKASLINSQQHLVLKAQHPSPLAANSIRTSKWPKFIGCDHFIQANNYLKEHNKNPIDWNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5KZI9</accession>
    <name>A0A0M5KZI9_9GAMA</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
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            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100443"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="217" mass="25096" checksum="5FDAD3F014C1F3F4" modified="2015-12-09" version="1">MGSKLSLTSVFTTICSFMMSIICLLLAVNSMLHLKNVVEVGSFIITDHMEVRSEPSQSNNWETFNFSIENRSYIPTYYYPQYVNLNINFSSVKPNCSNCSKTNATFVGSNTCYYFTTVKHTFKECFTACVNISNCYFFFGNFNNMSLVRSHINKTKTYWVGAYRDVSDTYWRDLNKSQVDVYDVYQSTCAFISRYTPVPRSAFDCNYKRFCVCGGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5L1U4</accession>
    <name>A0A0M5L1U4_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F17</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
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            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
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            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14739.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="26100418"/>
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    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="433" mass="49881" checksum="8DEC79689351F6C1" modified="2015-12-09" version="1">MWYLFVLALTFQHANAEDNGENILGEVTGVSTNFKVKSLRLEVGLWTSMFCDISYYGRLIVSTDISNRTWIVKIPVSFEKHFIPHQILKETLYFYLDGKDFSLYKHVILADGENSILTKVFGINDQFNVNVTTDSLFLNIQGILTHMPVYIFRFVSYKSGIVSCQRFVVNSIEHKKLSDVYVFFWNINGIVMDINSRAFVNKTGNITVLEKLDHDDCMTRVILRCDKWLSRDLKNITYMYTMKKEKMFNSSCLLNNYAQSASICVLFDLIKNRPLEKLTLNVTSFANMCKNSITDSDFRCGVSFPIQSDGYVINIISSLGSQIHIFSSVYMKESLDKVWSGSFYPLSIKIDPGATLLVYISVYDKNSLVEEGYWNIKTIKGNIRFIRAHSILPNVNMTLGTHGEFTLYALKEYTYVVSLMSDYVKEKYNFVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5L4A2</accession>
    <name>A0A0M5L4A2_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173872.1">
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    </dbReference>
    <dbReference type="GeneID" id="26100473"/>
    <dbReference type="KEGG" id="vg:26100473"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="716" mass="78603" checksum="170DBD84B245C748" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5L4A8</accession>
    <name>A0A0M5L4A8_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ORF55</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays several roles during the time course of infection, including egress of virus particles from the perinuclear space and secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Virion tegument</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the herpesviridae UL51 family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173934.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100448"/>
    <dbReference type="KEGG" id="vg:26100448"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044177">
        <property type="term" value="C:host cell Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007619">
        <property type="entry name" value="Herpes_U44"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04533">
        <property type="entry name" value="Herpes_U44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ALE14769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="206" mass="23204" checksum="0378DAF062323D70" modified="2015-12-09" version="1">MSNWLQFSCCGLWPFGRLTPRYERLLSNNDEYSRIKSEIDIGLPPGVSIGDMFQNNQSTEILKQAYLLAVQSNNITDYLQRFDCVRIPESCKHTIANQISKLKSVQYIIWNTMISMAIGNVTIDDSALKALLDKQAGESIALIEMEKLVTALQMDVSKNWAHEIAQTVVQPPQSVITITNNPDLQTLTNPNQTTSKNSNKQIEILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5L623</accession>
    <name>A0A0M5L623_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F8</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173879.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100393"/>
    <dbReference type="KEGG" id="vg:26100393"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ALE14714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="55" mass="5985" checksum="35BE53187C74FA63" modified="2015-12-09" version="1">MGYESLGAYIALSGPTHITATLVDRQGEKEITNPDILNKKPLITINPITLFSSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5L624</accession>
    <name>A0A0M5L624_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Capsid scaffolding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protease precursor</fullName>
            <shortName evidence="7">pPR</shortName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="7">Assemblin</fullName>
                <ecNumber evidence="7">3.4.21.97</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Protease</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Assembly protein</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Capsid assembly protein</fullName>
            </alternativeName>
        </component>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Assemblin: Protease that plays an essential role in virion assembly within the nucleus. Catalyzes the cleavage of the assembly protein after formation of the spherical procapsid. By that cleavage, the capsid matures and gains its icosahedral shape. The cleavage sites seem to include -Ala-Ser-, -Ala-Ala-, as well as Ala-Thr bonds. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Assembly protein: Plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Capsid scaffolding protein: Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Cleaves -Ala-|-Ser- and -Ala-|-Ala- bonds in the scaffold protein.</text>
            <dbReference type="EC" id="3.4.21.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Capsid scaffolding protein homomultimerizes and interacts with major capsid protein. Assemblin exists in a monomer-dimer equilibrium with the dimer being the active species. Assembly protein homomultimerizes and interacts with major capsid protein.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Capsid scaffolding protein</molecule>
        <subcellularLocation>
            <location evidence="7">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Assembly protein</molecule>
        <subcellularLocation>
            <location evidence="7">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Assemblin</molecule>
        <subcellularLocation>
            <location evidence="7">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Region of interaction between pPR and pAP is called Amino conserved domain (ACD). The region of interaction with major capsid protein is called carboxyl conserved domain (CCD).</text>
    </comment>
    <comment type="PTM">
        <text evidence="7">Capsid scaffolding protein is cleaved by assemblin after formation of the spherical procapsid. As a result, the capsid obtains its mature, icosahedral shape. Cleavages occur at two or more sites: release and tail site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the herpesviridae capsid scaffolding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.97" evidence="7"/>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173892.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100406"/>
    <dbReference type="KEGG" id="vg:26100406"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.16.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04008">
        <property type="entry name" value="HSV_SCAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035443">
        <property type="entry name" value="Herpes_virus_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001847">
        <property type="entry name" value="Peptidase_S21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00716">
        <property type="entry name" value="Peptidase_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00236">
        <property type="entry name" value="HSVCAPSIDP40"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="7" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 7" id="KW-0118">Viral capsid assembly</keyword>
    <keyword evidence="2 7" id="KW-1188">Viral release from host cell</keyword>
    <feature type="chain" id="PRO_5023243818" description="Capsid scaffolding protein" evidence="7">
        <location>
            <begin position="1"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023243816" description="Assemblin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023243817" description="Assembly protein" evidence="7">
        <location>
            <begin position="229"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with major capsid protein" evidence="7">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by assemblin; Release site" evidence="7">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ALE14727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="538" mass="60466" checksum="7BAA5EA4157A4F7C" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5L630</accession>
    <name>A0A0M5L630_9GAMA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF73</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">31286</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173954.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100468"/>
    <dbReference type="KEGG" id="vg:26100468"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037007">
        <property type="entry name" value="EBNA1_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALE14789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="518" mass="56647" checksum="269239777B60D740" modified="2015-12-09" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2015-12-09" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0M5L637</accession>
    <name>A0A0M5L637_9GAMA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Triplex capsid protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRX1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Felis catus gammaherpesvirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1452540"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Gammaherpesvirinae</taxon>
            <taxon>Percavirus</taxon>
            <taxon>Felid gammaherpesvirus 1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Genome Announc." volume="3" first="e01192" last="15">
            <title>First Complete Genome Sequence of Felis catus Gammaherpesvirus 1.</title>
            <authorList>
                <person name="Troyer R.M."/>
                <person name="Lee J.S."/>
                <person name="Vuyisich M."/>
                <person name="Chain P."/>
                <person name="Lo C.C."/>
                <person name="Kronmiller B."/>
                <person name="Bracha S."/>
                <person name="Avery A.C."/>
                <person name="VandeWoude S."/>
            </authorList>
            <dbReference type="PubMed" id="26543105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">31286</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with TRX2, MCP and capsid vertex component 2/CVC2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae TRX1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT595939">
        <property type="protein sequence ID" value="ALE14777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009173942.1">
        <property type="nucleotide sequence ID" value="NC_028099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26100456"/>
    <dbReference type="KEGG" id="vg:26100456"/>
    <dbReference type="Proteomes" id="UP000152314">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04018">
        <property type="entry name" value="HSV_TRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004999">
        <property type="entry name" value="Herpes_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03327">
        <property type="entry name" value="Herpes_VP19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ALE14777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000152314"/>
        </source>
    </evidence>
    <sequence length="334" mass="37679" checksum="BDF1966B258C49D3" modified="2015-12-09" version="1">MKTIPQRYEKITKDFSGLIPPKSHKFSLASKSGLVNITNTVAKYAPKISISSLINQHAGVFDPPYRQPQFGEFLIFARTLHSQEPIGTFLFTFKQQEAVGENVDIIFSPVSLFKVSRLQEESGPNTYRMANIWYEQETDILQSVPNIQELFDNGTFHKHLTPVGPLVQNVNSTYLNKVVSVVRGEVLTKRTPRENVKLLLPADLYFNLDESLFPHLIDKEPSHLNVFYYACITYTRVFDQPAASVMFFRTSKGLCEVMMQLKLFFSNLITNRLAYGEAGQLNIKRVNLGALCKVGYSSAQTQPNQKSVLIRGAAFSVVEIPDFITDPGSWVSLI</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>