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<entry dataset="TrEMBL" created="2016-03-16" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0U4B8Q6</accession>
    <name>A0A0U4B8Q6_9PAPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein E7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">E7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Canis familiaris papillomavirus 17</name>
        <dbReference type="NCBI Taxonomy" id="1778550"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Zurhausenvirales</taxon>
            <taxon>Papillomaviridae</taxon>
            <taxon>Firstpapillomavirinae</taxon>
            <taxon>Taupapillomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Vet. Microbiol." volume="182" first="135" last="140">
            <title>Genomic characterisation of canine papillomavirus type 17, a possible rare cause of canine oral squamous cell carcinoma.</title>
            <authorList>
                <person name="Munday J.S."/>
                <person name="Dunowska M."/>
                <person name="Laurie R.E."/>
                <person name="Hills S."/>
            </authorList>
            <dbReference type="PubMed" id="26711040"/>
            <dbReference type="DOI" id="10.1016/j.vetmic.2015.11.015"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">OralSCCPV</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">E7 protein has both transforming and trans-activating activities.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Homooligomer. Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity. Interacts with host EP300; this interaction represses EP300 transcriptional activity. Interacts with protein E2; this interaction inhibits E7 oncogenic activity. Interacts with host TMEM173/STING; this interaction impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Host nucleus</location>
        </subcellularLocation>
        <text evidence="10">Predominantly found in the host nucleus.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The E7 terminal domain is an intrinsically disordered domain, whose flexibility and conformational transitions confer target adaptability to the oncoprotein. It allows adaptation to a variety of protein targets and exposes the PEST degradation sequence that regulates its turnover in the cell.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Highly phosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the papillomaviridae E7 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT272399">
        <property type="protein sequence ID" value="ALY11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000130688">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039645">
        <property type="term" value="P:modulation by virus of host G1/S transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:suppression by virus of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04004">
        <property type="entry name" value="PPV_E7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000148">
        <property type="entry name" value="Papilloma_E7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00527">
        <property type="entry name" value="E7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003407">
        <property type="entry name" value="Papvi_E7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0010">Activator</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10 11" id="KW-0244">Early protein</keyword>
    <keyword evidence="9 10" id="KW-1078">G1/S host cell cycle checkpoint dysregulation by virus</keyword>
    <keyword evidence="10" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="4 10" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="10" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="10" id="KW-1114">Inhibition of host interferon signaling pathway by virus</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 10" id="KW-1121">Modulation of host cell cycle by virus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0899">Viral immunoevasion</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="short sequence motif" description="Nuclear export signal" evidence="10">
        <location>
            <begin position="69"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR003407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ALY11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000130688"/>
        </source>
    </evidence>
    <sequence length="98" mass="11037" checksum="5B6329A5B6DB60FC" modified="2016-03-16" version="1">MRGVSPTIKDVELELKDLVIPTNLLSGETLEAEEEEFAPEPGRYRVVTPCNICHSSLRLFVEVADETQIHRFHQLLLDGLGIVCATCHRTHFSHGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0U4B8R4</accession>
    <name>A0A0U4B8R4_9PAPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Major capsid protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">L1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Canis familiaris papillomavirus 17</name>
        <dbReference type="NCBI Taxonomy" id="1778550"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Zurhausenvirales</taxon>
            <taxon>Papillomaviridae</taxon>
            <taxon>Firstpapillomavirinae</taxon>
            <taxon>Taupapillomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Vet. Microbiol." volume="182" first="135" last="140">
            <title>Genomic characterisation of canine papillomavirus type 17, a possible rare cause of canine oral squamous cell carcinoma.</title>
            <authorList>
                <person name="Munday J.S."/>
                <person name="Dunowska M."/>
                <person name="Laurie R.E."/>
                <person name="Hills S."/>
            </authorList>
            <dbReference type="PubMed" id="26711040"/>
            <dbReference type="DOI" id="10.1016/j.vetmic.2015.11.015"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">OralSCCPV</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation. Interacts with protein E2; this interaction enhances E2-dependent replication and transcription activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the papillomaviridae L1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KT272399">
        <property type="protein sequence ID" value="ALY11244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000130688">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039620">
        <property type="term" value="C:T=7 icosahedral viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075509">
        <property type="term" value="P:endocytosis involved in viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019062">
        <property type="term" value="P:virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.175.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04002">
        <property type="entry name" value="PPV_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002210">
        <property type="entry name" value="Capsid_L1_Papillomavir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036973">
        <property type="entry name" value="Capsid_L1_sf_Papillomavir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011222">
        <property type="entry name" value="dsDNA_vir_gr_I_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00500">
        <property type="entry name" value="Late_protein_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00865">
        <property type="entry name" value="HPVCAPSIDL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88648">
        <property type="entry name" value="SSF88648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="1 4 5" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3 4 5" id="KW-0426">Late protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1145">T=7 icosahedral capsid protein</keyword>
    <keyword evidence="4 5" id="KW-1161">Viral attachment to host cell</keyword>
    <keyword evidence="4" id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0946">Virion</keyword>
    <keyword evidence="4" id="KW-1164">Virus endocytosis by host</keyword>
    <keyword evidence="4 5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-429)" evidence="4">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-173)" evidence="4">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ALY11244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000130688"/>
        </source>
    </evidence>
    <sequence length="506" mass="57635" checksum="D93C7EED5191B3BE" modified="2016-03-16" version="1">MAFWMQAQGKVYLPPPKPIGKVLHTDDFVRPTSIYYHGSTDRLLTVGNPYFTVKHEETVIVPKVTGNQFRAFRLKLPDPNKFALSDPTVYNPENERVVWKLAGIEIGRGGPLGFGTTGNYLFDKLQDTENSNKYQAKGKDDRQNISLDPKQTQLFVVGCTPCKGEHWDIAQKCAEQDPRYQPGDCPPLKLVSSVIQDGEMCDVGFGAMNFKTLQFNKSGVPMDIVDTTCKWPDFLQMTNEKYGNSCFFYGRREQVYCRHMFVRSGSTNEKVPKDLIMDGDDPKTAAKADYCYVGTPSGSLVTSDSQIFNRPYWIKQAQGHNNGVIWNNNLFVTVVDNTRNTNFTISQSTTLETEPYNNDRMRNYVRHVEEYELTFIVQLCKVALDPEILSHLNQMDPSILENWNLGFIPPPAPGLESNYRYIESLATMCPAAEPPKKKEDPYDNMTFWTVDMTEKLSLELDQYSLGRRFLYQYSLKRTPSALRTTGVKRPSTLVKRASASKKRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0U4IR22</accession>
    <name>A0A0U4IR22_9PAPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E4</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Canis familiaris papillomavirus 17</name>
        <dbReference type="NCBI Taxonomy" id="1778550"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Zurhausenvirales</taxon>
            <taxon>Papillomaviridae</taxon>
            <taxon>Firstpapillomavirinae</taxon>
            <taxon>Taupapillomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Vet. Microbiol." volume="182" first="135" last="140">
            <title>Genomic characterisation of canine papillomavirus type 17, a possible rare cause of canine oral squamous cell carcinoma.</title>
            <authorList>
                <person name="Munday J.S."/>
                <person name="Dunowska M."/>
                <person name="Laurie R.E."/>
                <person name="Hills S."/>
            </authorList>
            <dbReference type="PubMed" id="26711040"/>
            <dbReference type="DOI" id="10.1016/j.vetmic.2015.11.015"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">OralSCCPV</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KT272399">
        <property type="protein sequence ID" value="ALY11240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000130688">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ALY11240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000130688"/>
        </source>
    </evidence>
    <sequence length="259" mass="28753" checksum="D6E48DE3005A42FB" modified="2016-03-16" version="1">MRDFITQMRMEKKYTMSSLLRMQCALATLAHGRSAIKILFCLPLFLVRGPRGPHQPPPQIPPPPPPQPHNGKDPLTPQPPPQPHPPSPPPAAAPPPGTEEDPGSSSSQNPNKGDQREDEDEDEDEDEGAERGEGRHPHRCLFTLIGDAGNHRGRRRGRGKRRLTGRIGPLGGEDESEERGKENAQVVPRVIFPPTPPRSPPSPPLAPLPDTDTEEDQPQRPPDSLLQCLWNSWSRDLEILKQKWDDGLEDLKDKIGLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0U4IRM5</accession>
    <name>A0A0U4IRM5_9PAPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Minor capsid protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">L2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Canis familiaris papillomavirus 17</name>
        <dbReference type="NCBI Taxonomy" id="1778550"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Zurhausenvirales</taxon>
            <taxon>Papillomaviridae</taxon>
            <taxon>Firstpapillomavirinae</taxon>
            <taxon>Taupapillomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Vet. Microbiol." volume="182" first="135" last="140">
            <title>Genomic characterisation of canine papillomavirus type 17, a possible rare cause of canine oral squamous cell carcinoma.</title>
            <authorList>
                <person name="Munday J.S."/>
                <person name="Dunowska M."/>
                <person name="Laurie R.E."/>
                <person name="Hills S."/>
            </authorList>
            <dbReference type="PubMed" id="26711040"/>
            <dbReference type="DOI" id="10.1016/j.vetmic.2015.11.015"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">OralSCCPV</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with major capsid protein L1. Interacts with E2; this interaction inhibits E2 transcriptional activity but not the DNA replication function E2. Interacts with host HSPA8; this interaction is required for L2 nuclear translocation. Interacts with host importins KPNB2 and KPNB3. Forms a complex with importin alpha2-beta1 heterodimers via interaction with the importin alpha2 adapter. Interacts with host DYNLT1; this interaction is essential for virus intracellular transport during entry. Interacts (via C-terminus) with host retromer subunits VPS35 AND VPS29.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Highly phosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the papillomaviridae L2 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT272399">
        <property type="protein sequence ID" value="ALY11245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000130688">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044174">
        <property type="term" value="C:host cell endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044177">
        <property type="term" value="C:host cell Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075521">
        <property type="term" value="P:microtubule-dependent intracellular transport of viral material towards nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075732">
        <property type="term" value="P:viral penetration into host nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04003">
        <property type="entry name" value="PPV_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000784">
        <property type="entry name" value="Late_L2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00513">
        <property type="entry name" value="Late_protein_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4 5" id="KW-1176">Cytoplasmic inwards viral transport</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1039">Host endosome</keyword>
    <keyword evidence="1" id="KW-1040">Host Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="5" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-0426">Late protein</keyword>
    <keyword evidence="2 5" id="KW-1177">Microtubular inwards viral transport</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1163">Viral penetration into host nucleus</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="22"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ALY11245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000130688"/>
        </source>
    </evidence>
    <sequence length="511" mass="54104" checksum="45BCAAC116254345" modified="2016-03-16" version="1">MQPTMRAKRVKRASAEQLYKTCQQGGDCIPDVVAKYEHKTPADKILQIGGSVIYLGGLSIGTGKGTGGSTGYRPLGVDVNASTTRPVLPRPAIPTETIGVDVGSGTVSAGESSIIPLLEAGAGGDAVTISPEVPTITEDLVINPSSGAPTVTTAAGEGESVAVLEVGTTPSTNSRVTSTSQHTNPSFTPVFHSTPQPGEASTLESIVVGHSTGGRVVDVYEEIPLDDFGPSEFEIEDPTPRTSTPRSAVTNLVQRARQFYNRRFAQVQVTNEAFLSRPASLVEFENPAYQPEETVVFPAGSGEPLAAPDPDFADVRVLNRAVFQANPRGGVRVSRLGTKNTIRLRSGTHIGGSTHYFYDLSSISLQPEIELSVLGEHSGESEIVLGSTTSTVIDAVNVEGTISVPEEDVLLDEYVEDFSHSQLALSGGSRSQSRVVDIPEFQREVPKGSVIIDDLSDSIHVAHPGGRDTTAEPFSPPHSSDVPSSSSDSVSSTFDLHPSLLKRRKRKRGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0U4JWN8</accession>
    <name>A0A0U4JWN8_9PAPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Regulatory protein E2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">E2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Canis familiaris papillomavirus 17</name>
        <dbReference type="NCBI Taxonomy" id="1778550"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Zurhausenvirales</taxon>
            <taxon>Papillomaviridae</taxon>
            <taxon>Firstpapillomavirinae</taxon>
            <taxon>Taupapillomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Vet. Microbiol." volume="182" first="135" last="140">
            <title>Genomic characterisation of canine papillomavirus type 17, a possible rare cause of canine oral squamous cell carcinoma.</title>
            <authorList>
                <person name="Munday J.S."/>
                <person name="Dunowska M."/>
                <person name="Laurie R.E."/>
                <person name="Hills S."/>
            </authorList>
            <dbReference type="PubMed" id="26711040"/>
            <dbReference type="DOI" id="10.1016/j.vetmic.2015.11.015"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">OralSCCPV</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Binds DNA as homodimer. Interacts with protein E1; this interaction greatly increases E1 DNA-binding activity. Interacts with protein L1; this interaction enhances E2-dependent replication and transcription activation. Interacts with protein L2; this interaction inhibits E2 transcriptional activity but not DNA replication function E2. Interacts with protein E7; this interaction inhibits E7 oncogenic activity. Interacts with host TAF1; this interaction modulates E2-dependent transcriptional regulation. Interacts with host BRD4; this interaction mediates E2 transcriptional activation function. Additionally, the interaction with host BRD4 on mitotic chromosomes mediates tethering of the viral genome. Interacts with host TOPBP1; this interaction is required for optimal viral DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Phosphorylated.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13">Sumoylation plays a regulatory role in E2 transcriptional activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the papillomaviridae E2 protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the papillomaviridae E8^E2C protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT272399">
        <property type="protein sequence ID" value="ALY11241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000130688">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039693">
        <property type="term" value="P:viral DNA genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04001">
        <property type="entry name" value="PPV_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035975">
        <property type="entry name" value="E2/EBNA1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000427">
        <property type="entry name" value="Papillomavirus_E2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001866">
        <property type="entry name" value="Papillomavirus_E2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033668">
        <property type="entry name" value="Reg_prot_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036050">
        <property type="entry name" value="Regulatory_protein_E2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042503">
        <property type="entry name" value="Regulatory_protein_E2_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042504">
        <property type="entry name" value="Regulatory_protein_E2_N_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00511">
        <property type="entry name" value="PPV_E2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00508">
        <property type="entry name" value="PPV_E2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51332">
        <property type="entry name" value="SSF51332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54957">
        <property type="entry name" value="SSF54957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0010">Activator</keyword>
    <keyword evidence="8 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0244">Early protein</keyword>
    <keyword evidence="7 13" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="13" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0678">Repressor</keyword>
    <keyword evidence="12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PPV_E2_N" evidence="15">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PPV_E2_C" evidence="16">
        <location>
            <begin position="414"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="202"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="DNA-binding domain" evidence="13">
        <location>
            <begin position="412"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="202"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)" evidence="13">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ALY11241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000130688"/>
        </source>
    </evidence>
    <sequence length="496" mass="54419" checksum="EDB57E6A397C2683" modified="2016-03-16" version="1">MMEALVRRCDVLQEVILQHYERGSHKLSDQCNYWEATRRESTLLHFARKNRIHRLGVIPVPALATTEANAKKAIQMCLVLSSLNQSPYRDEPWTMTDTSREMWEAPPKGCLKKGGVTVDVLFDGDPNNVFPYTLWSYIYYQNLNDEWIKVPGKVDYEGLYYTDEDGEKIYYEQFAKDAMRFGNTGTWKVRYKNTVLSALVSSSGSSWPTSAPTSNSATASTTTAQREGPTDTPASSATSSSVSSACSSTSTGNRGGPGQLIVSESQQGGSEGGRGRGRGRGRGRGKRGGSPSPPLFVHSDWGCREPQGSEKRAREASSDGEDRATWGGGRERRAGQGERPSCSSCNLSPNPSTIPTLSTPGPTPGHGHGGRPTPKAPRLSPAVPLEQLVQRPGDFETEVGRRPRGPEGQNRPYPVIIVKGDGNASKCWRRRLRLRYGELYTAISTGFSWTTANGPHRVCRPRMVIAFDSDEQRAAFLKNVRIPKVLDIAFGSLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0U4K543</accession>
    <name>A0A0U4K543_9PAPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein E6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">E6</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Canis familiaris papillomavirus 17</name>
        <dbReference type="NCBI Taxonomy" id="1778550"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Zurhausenvirales</taxon>
            <taxon>Papillomaviridae</taxon>
            <taxon>Firstpapillomavirinae</taxon>
            <taxon>Taupapillomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Vet. Microbiol." volume="182" first="135" last="140">
            <title>Genomic characterisation of canine papillomavirus type 17, a possible rare cause of canine oral squamous cell carcinoma.</title>
            <authorList>
                <person name="Munday J.S."/>
                <person name="Dunowska M."/>
                <person name="Laurie R.E."/>
                <person name="Hills S."/>
            </authorList>
            <dbReference type="PubMed" id="26711040"/>
            <dbReference type="DOI" id="10.1016/j.vetmic.2015.11.015"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">OralSCCPV</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity. Interacts with host BAK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 4">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the papillomaviridae E6 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KT272399">
        <property type="protein sequence ID" value="ALY11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000130688">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039526">
        <property type="term" value="P:modulation by virus of host apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039649">
        <property type="term" value="P:modulation by virus of host ubiquitin-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:suppression by virus of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04006">
        <property type="entry name" value="HPV_E6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001334">
        <property type="entry name" value="E6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038575">
        <property type="entry name" value="E6_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00518">
        <property type="entry name" value="E6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161229">
        <property type="entry name" value="SSF161229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0244">Early protein</keyword>
    <keyword evidence="3" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-1119">Modulation of host cell apoptosis by virus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0899">Viral immunoevasion</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" evidence="3">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="3">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ALY11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000130688"/>
        </source>
    </evidence>
    <sequence length="136" mass="15311" checksum="A3C9DFB3C6E6FA69" modified="2016-03-16" version="1">MARLQTLGSLCAFYNSDLDSILVPCIFCDRFLDGKDKRAFDGKSLSLVWRSGIPYAVCSPCCVERAFEDCCKNVIVTLEGDGVEKLCMRPLCEVPVRCKYCLKPLSAGEKIRCVEKRQPFGLIRGRWRNVCGNCED</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>