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<entry dataset="TrEMBL" created="2010-11-02" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA89</accession>
    <name>E1AA89_9REOV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CanAr 42</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reoviridae RNA-directed RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="2"/>
    <dbReference type="EMBL" id="HM543465">
        <property type="protein sequence ID" value="ADM88592.1"/>
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    <dbReference type="RefSeq" id="YP_003896058.1">
        <property type="nucleotide sequence ID" value="NC_014522.1"/>
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    <dbReference type="GeneID" id="9970137"/>
    <dbReference type="KEGG" id="vg:9970137"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
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    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019079">
        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007097">
        <property type="entry name" value="RNA-dir_pol_reovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008723">
        <property type="entry name" value="RNA_pol_orbivir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05788">
        <property type="entry name" value="Orbi_VP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50523">
        <property type="entry name" value="RDRP_DSRNA_REO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRp catalytic" evidence="7">
        <location>
            <begin position="547"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ADM88592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="1285" mass="146845" checksum="3F3794406FB2731A" modified="2010-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA90</accession>
    <name>E1AA90_9REOV</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VP2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CanAr 42</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the orbivirus VP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HM543466">
        <property type="protein sequence ID" value="ADM88593.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896059.1">
        <property type="nucleotide sequence ID" value="NC_014523.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9970135"/>
    <dbReference type="KEGG" id="vg:9970135"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002614">
        <property type="entry name" value="Inner_layer_core_VP3_Orbivir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016029">
        <property type="entry name" value="Inner_layer_core_VP3_Reovir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01700">
        <property type="entry name" value="Orbi_VP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56831">
        <property type="entry name" value="SSF56831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADM88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="908" mass="102905" checksum="0A5F3A262821C769" modified="2010-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA91</accession>
    <name>E1AA91_9REOV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core protein VP4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CanAr 42</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the orbivirus VP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="HM543467">
        <property type="protein sequence ID" value="ADM88594.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896060.1">
        <property type="nucleotide sequence ID" value="NC_014524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9970227"/>
    <dbReference type="KEGG" id="vg:9970227"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039624">
        <property type="term" value="C:viral outer capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20758">
        <property type="entry name" value="capping_2-OMTase_Orbivirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007753">
        <property type="entry name" value="Orbi_VP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043026">
        <property type="entry name" value="Orbi_VP4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05059">
        <property type="entry name" value="Orbi_VP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="5" id="KW-1152">Outer capsid protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ADM88594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="635" mass="72812" checksum="9D008AA743BCF308" modified="2010-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA92</accession>
    <name>E1AA92_9REOV</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-structural protein NS1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CanAr 42</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM543468">
        <property type="protein sequence ID" value="ADM88595.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896061.1">
        <property type="nucleotide sequence ID" value="NC_014525.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9970139"/>
    <dbReference type="KEGG" id="vg:9970139"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002630">
        <property type="entry name" value="Orbi_NS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01718">
        <property type="entry name" value="Orbi_NS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADM88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="531" mass="59865" checksum="0A19CBC73DFC7B32" modified="2010-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA93</accession>
    <name>E1AA93_9REOV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VP4</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CanAr 42</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM543469">
        <property type="protein sequence ID" value="ADM88596.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896062.1">
        <property type="nucleotide sequence ID" value="NC_014526.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9970141"/>
    <dbReference type="KEGG" id="vg:9970141"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADM88596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="551" mass="62324" checksum="D8F34D72BCD51C85" modified="2010-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA94</accession>
    <name>E1AA94_9REOV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Outer capsid protein VP5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CanAr 42</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">VP5 protein is one of the two proteins (with VP2) which constitute the virus particle outer capsid. Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. Permeabilization activity is probably negatively regulated by VP2 and is triggered by endosomal degradation of VP2 and exposure to low pH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the orbivirus VP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="HM543470">
        <property type="protein sequence ID" value="ADM88597.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896063.1">
        <property type="nucleotide sequence ID" value="NC_014527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9970143"/>
    <dbReference type="KEGG" id="vg:9970143"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000145">
        <property type="entry name" value="Capsid_VP5_Orbivir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00901">
        <property type="entry name" value="Orbi_VP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADM88597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="537" mass="59510" checksum="55B2E1D357841649" modified="2010-11-02" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA95</accession>
    <name>E1AA95_9REOV</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core protein VP7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CanAr 42</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the orbivirus VP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HM543471">
        <property type="protein sequence ID" value="ADM88598.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896064.1">
        <property type="nucleotide sequence ID" value="NC_014528.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9970145"/>
    <dbReference type="KEGG" id="vg:9970145"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039624">
        <property type="term" value="C:viral outer capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001803">
        <property type="entry name" value="Orbi_VP7_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023178">
        <property type="entry name" value="Orbi_VP7_capsid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023176">
        <property type="entry name" value="Orbi_VP7_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008935">
        <property type="entry name" value="Virus_capsid_a-hlx_vir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00897">
        <property type="entry name" value="Orbi_VP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00903">
        <property type="entry name" value="VP7CAPSID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48345">
        <property type="entry name" value="SSF48345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1152">Outer capsid protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ADM88598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="357" mass="39641" checksum="002F20FF50254110" modified="2010-11-02" version="1">MDAYTARALSVLEGLAISGDPRSHRDPTTEATMSIFAMRFNSTTSRPVIGTPTTREARRNNFYAAVDVAFATLNITSTFVMPGYIQNPQTLAILARDEIPYTPSTFRRVQRIRICTNDHSNVREERHAYSHYEAVTSPGVVLPAPAGGGPRCYAISATTLQIHIDAMQNEVLTPLIFPDQDDVIMAEFIWQRLANGIDNNAVINMGTNVELLRDNAAVEGGTPFMATPRDHVVLASYEPVNLCTIHLTCTRYWVTAPPRVVYDSMEADILAVYTYRDEFWDALRSYVLQALGMPAHHYPTRPVTEFRQNLAIAILSRLFDVYCAMAPEINPPVAAQGVVGGLAHRLQAALRAFRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA96</accession>
    <name>E1AA96_9REOV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-structural protein NS2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CanAr 42</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single-stranded RNA-binding protein.</text>
    </comment>
    <dbReference type="EMBL" id="HM543472">
        <property type="protein sequence ID" value="ADM88599.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896065.1">
        <property type="nucleotide sequence ID" value="NC_014529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9970152"/>
    <dbReference type="KEGG" id="vg:9970152"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007602">
        <property type="entry name" value="BTV_NS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037194">
        <property type="entry name" value="NS2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04514">
        <property type="entry name" value="BTV_NS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110132">
        <property type="entry name" value="SSF110132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ADM88599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="359" mass="38875" checksum="F2A7201DB52A0B0E" modified="2010-11-02" version="1">MSADKQIPMIRKPFTRTIVLKSTGKDDYVAKMCNALGCEYLVVRHGLGMHVAGSNTPTHGCMLLLIPGAGSFRLIDRDQSTFVVVSSDGLEVQQDRWPGMRFEAVDMFPRCCRIVVGDVAADSEIRFGSASGTVPPYTAGESMEAQDEISLPGLDFSVPDSDLREYREKLREEKEERAAAILSALRTTQQSRTLGRLHGVKTSDLVTLRPPQPPTPGRNGHSALMSSAPVPPPLVPTSSSTGSPALSTTGLKRTQKLAPPPVAESAGPTFGADSNRFIEEALEAVMQDDASGRLNFGGEPESVGLFSQNLGSFDIPPSQLPAYEIDETRNKYKYVGMRTSTRLHALACDDRVYFVPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA97</accession>
    <name>E1AA97_9REOV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VP6(Hel)</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CanAr 42</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HM543473">
        <property type="protein sequence ID" value="ADM88600.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896066.1">
        <property type="nucleotide sequence ID" value="NC_014530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9970150"/>
    <dbReference type="KEGG" id="vg:9970150"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001399">
        <property type="entry name" value="Orbi_VP6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01516">
        <property type="entry name" value="Orbi_VP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ADM88600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="321" mass="34451" checksum="46965515EBA2C1D3" modified="2010-11-02" version="1">MSTRLILLAPGDVIVSVGDQLVQRGVDVRVARYDYQSTDQNELPAGARAAETSPGQTREFGDRAGSGTSRVEVDPGTKGSAQRTSTESTSGSADAHVRDQASRSDAAQGDTASRDGLHAAGHGRAVGGGGDTRNTAQSSESPAGSHSMESRGPEAGPGVPFVATARIRDALRERGYPDIRVLGSEIPIPDRDRVLLFGAAALKELGVGQDENAAQKDAEAKLRRDKVRSAMTVERIHSAQRVNEEFPIKKRERQHLTPVVLVTNDPQYVQRAHILYTAPTGDLSWKETARKATQRRDIRAYAYGEHDKSPGEALLTLVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA98</accession>
    <name>E1AA98_9REOV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VP6(DBP)</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CanAr 42</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM543473">
        <property type="protein sequence ID" value="ADM88601.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896067.1">
        <property type="nucleotide sequence ID" value="NC_014530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="9970149"/>
    <dbReference type="KEGG" id="vg:9970149"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ADM88601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="190" mass="22526" checksum="AB77B0904A787B75" modified="2010-11-02" version="1">MSYRQEHVLRRLRQDRHGNLETARDLERPGWRWIQEQREALNVPARRARAEALTLTFGIRRVEATLPREILHLGMDFMLRGMDVPSEVVEILAILRNRAKVRREVIAWSLAARKRGLEFLLLPLHEYVTHCAKEDIRIYESSGLKSLFRIEIASCYLARPRLRSSELVRMRMLRRKTRRRSCVGTRCVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-11-02" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E1AA99</accession>
    <name>E1AA99_9REOV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NS3</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Great Island virus</name>
        <dbReference type="NCBI Taxonomy" id="204269"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Sedoreovirinae</taxon>
            <taxon>Orbivirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2985" last="2993">
            <title>Complete sequence of Great Island virus and comparison with the T2 and outer-capsid proteins of Kemerovo, Lipovnik and Tribec viruses (genus Orbivirus, family Reoviridae).</title>
            <authorList>
                <person name="Belhouchet M."/>
                <person name="Mohd Jaafar F."/>
                <person name="Tesh R.B."/>
                <person name="Grimes J."/>
                <person name="Maan S."/>
                <person name="Mertens P.P.C."/>
                <person name="Attoui H."/>
            </authorList>
            <dbReference type="PubMed" id="20739272"/>
            <dbReference type="DOI" id="10.1099/vir.0.024760-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CanAr 42</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM543474">
        <property type="protein sequence ID" value="ADM88602.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_003896068.1">
        <property type="nucleotide sequence ID" value="NC_014531.1"/>
    </dbReference>
    <dbReference type="TCDB" id="1.A.93.2.1">
        <property type="family name" value="the bluetongue virus non-structural protein 3 viroporin (ns3) family"/>
    </dbReference>
    <dbReference type="GeneID" id="9970147"/>
    <dbReference type="KEGG" id="vg:9970147"/>
    <dbReference type="Proteomes" id="UP000121369">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ADM88602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000121369"/>
        </source>
    </evidence>
    <sequence length="171" mass="19404" checksum="6C6DA2F2F4E43061" modified="2010-11-02" version="1">MKNEKAAYGAASEVLKDDETTRMLKMQVNECSLTEMRQTYQSLKRRCRLLYYGELLCLAAALGLTLVLMVPSASRVLEGALTQANITGHVITGILTSLAIFLQHHRARLLKRKRSIKRDIVKRMTYISLARRMGSQFPESAGAGSDFRARLMALAEEAERARDDSDWRRWP</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>