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    <name>G0YZL9_9REOV</name>
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        <submittedName>
            <fullName evidence="7">Core turret protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lambdaA</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Baboon orthoreovirus</name>
        <dbReference type="NCBI Taxonomy" id="75888"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Spinareovirinae</taxon>
            <taxon>Orthoreovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="1999" name="Virology" volume="260" first="316" last="328">
            <title>Extensive sequence divergence and phylogenetic relationships between the fusogenic and nonfusogenic orthoreoviruses: a species proposal.</title>
            <authorList>
                <person name="Duncan R."/>
            </authorList>
            <dbReference type="PubMed" id="10417266"/>
            <dbReference type="DOI" id="10.1006/viro.1999.9832"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2011" name="J. Virol." volume="85" first="7483" last="7495">
            <title>Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber.</title>
            <authorList>
                <person name="Yan X."/>
                <person name="Parent K.N."/>
                <person name="Goodman R.P."/>
                <person name="Tang J."/>
                <person name="Shou J."/>
                <person name="Nibert M.L."/>
                <person name="Duncan R."/>
                <person name="Baker T.S."/>
            </authorList>
            <dbReference type="PubMed" id="21593159"/>
            <dbReference type="DOI" id="10.1128/JVI.00729-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Outer capsid protein involved in mRNA capping. Catalyzes the last 3 enzymatic activities for formation of the 5' cap structure on the viral plus-strand transcripts, namely the RNA guanylyltransferase, RNA-7N- and RNA-2'O-methyltransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HQ847903">
        <property type="protein sequence ID" value="AEK86189.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769547.1">
        <property type="nucleotide sequence ID" value="NC_015877.1"/>
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    <dbReference type="KEGG" id="vg:11029894"/>
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    </dbReference>
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        <property type="term" value="C:viral outer capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0004484">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Reovirus_L2"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06016">
        <property type="entry name" value="Reovirus_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1152">Outer capsid protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AEK86189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000118514"/>
        </source>
    </evidence>
    <sequence length="1284" mass="146699" checksum="9B382E50A4F38D8E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>G0YZM0</accession>
    <name>G0YZM0_9REOV</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lambdaB</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Baboon orthoreovirus</name>
        <dbReference type="NCBI Taxonomy" id="75888"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Spinareovirinae</taxon>
            <taxon>Orthoreovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="1999" name="Virology" volume="260" first="316" last="328">
            <title>Extensive sequence divergence and phylogenetic relationships between the fusogenic and nonfusogenic orthoreoviruses: a species proposal.</title>
            <authorList>
                <person name="Duncan R."/>
            </authorList>
            <dbReference type="PubMed" id="10417266"/>
            <dbReference type="DOI" id="10.1006/viro.1999.9832"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2011" name="J. Virol." volume="85" first="7483" last="7495">
            <title>Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber.</title>
            <authorList>
                <person name="Yan X."/>
                <person name="Parent K.N."/>
                <person name="Goodman R.P."/>
                <person name="Tang J."/>
                <person name="Shou J."/>
                <person name="Nibert M.L."/>
                <person name="Duncan R."/>
                <person name="Baker T.S."/>
            </authorList>
            <dbReference type="PubMed" id="21593159"/>
            <dbReference type="DOI" id="10.1128/JVI.00729-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the reoviridae RNA-directed RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="2"/>
    <dbReference type="EMBL" id="HQ847904">
        <property type="protein sequence ID" value="AEK86190.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769548.1">
        <property type="nucleotide sequence ID" value="NC_015878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="11029896"/>
    <dbReference type="KEGG" id="vg:11029896"/>
    <dbReference type="Proteomes" id="UP000118514">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019013">
        <property type="term" value="C:viral nucleocapsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019079">
        <property type="term" value="P:viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012915">
        <property type="entry name" value="RdRP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007097">
        <property type="entry name" value="RNA-dir_pol_reovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07925">
        <property type="entry name" value="RdRP_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50523">
        <property type="entry name" value="RDRP_DSRNA_REO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1217"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="RdRp catalytic" evidence="7">
        <location>
            <begin position="554"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AEK86190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000118514"/>
        </source>
    </evidence>
    <sequence length="1261" mass="142987" checksum="09A1F30A52CF9431" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>G0YZM1</accession>
    <name>G0YZM1_9REOV</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lambdaC</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Baboon orthoreovirus</name>
        <dbReference type="NCBI Taxonomy" id="75888"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Spinareovirinae</taxon>
            <taxon>Orthoreovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="1999" name="Virology" volume="260" first="316" last="328">
            <title>Extensive sequence divergence and phylogenetic relationships between the fusogenic and nonfusogenic orthoreoviruses: a species proposal.</title>
            <authorList>
                <person name="Duncan R."/>
            </authorList>
            <dbReference type="PubMed" id="10417266"/>
            <dbReference type="DOI" id="10.1006/viro.1999.9832"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2011" name="J. Virol." volume="85" first="7483" last="7495">
            <title>Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber.</title>
            <authorList>
                <person name="Yan X."/>
                <person name="Parent K.N."/>
                <person name="Goodman R.P."/>
                <person name="Tang J."/>
                <person name="Shou J."/>
                <person name="Nibert M.L."/>
                <person name="Duncan R."/>
                <person name="Baker T.S."/>
            </authorList>
            <dbReference type="PubMed" id="21593159"/>
            <dbReference type="DOI" id="10.1128/JVI.00729-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="HQ847905">
        <property type="protein sequence ID" value="AEK86191.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769549.1">
        <property type="nucleotide sequence ID" value="NC_015879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="11029898"/>
    <dbReference type="KEGG" id="vg:11029898"/>
    <dbReference type="Proteomes" id="UP000118514">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039625">
        <property type="term" value="C:viral inner capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044949">
        <property type="entry name" value="Lambda-1/VP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="11" id="KW-1153">Inner capsid protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0946">Virion</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022561"/>
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                <person name="Goodman R.P."/>
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                <person name="Goodman R.P."/>
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</entry>
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        <citation type="journal article" date="2011" name="J. Virol." volume="85" first="7483" last="7495">
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                <person name="Goodman R.P."/>
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    </comment>
    <dbReference type="EMBL" id="AF059719">
        <property type="protein sequence ID" value="AAC18124.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769553.1">
        <property type="nucleotide sequence ID" value="NC_015883.1"/>
    </dbReference>
    <dbReference type="GeneID" id="11039979"/>
    <dbReference type="KEGG" id="vg:11039979"/>
    <dbReference type="Proteomes" id="UP000118514">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004317">
        <property type="entry name" value="Sigma_1_2_reovir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03084">
        <property type="entry name" value="Sigma_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC18124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000118514"/>
        </source>
    </evidence>
    <sequence length="413" mass="47944" checksum="A7A4DBA7F3D0C34A" modified="1998-08-01" version="1">MARAHYPYVTGLWSEPVIPFQKSQINHLLRSSNSVWQDATLSKTWPVIRSRVYTREIPCAGSVLYQRNLLYSSFVPILLIDKDAWKEYQFQDTTWTGPEGKNLVRRTPYQEMVEYDPQPARYYDVHEYRTWQRQLLLLQRIYPQLMVSNMLNLSQFGPITYLDTDARMLEPLVLNILTTWIGKSFEEIAIKLLQTINNHALVADSNNDLALRLINTIFWLSSAGILNQNRTIRGFFFLTKRRGVSEESFILNYNHHGERVNLEGYKYGFFAIRSPDWNRYLSYSLSAGLSAMVLSNRSPKLLSNNDVNDSYTSLPHLTGPLGDRVYYISSSVLADEYIDTQYIIGQISGKERDQMILNKDVEYDRSRAYLTAVLDEDDELQIARRIKPFNEVDWLPGESRIGIHGLELLINQS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2020-08-12" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>O72465</accession>
    <name>O72465_9REOV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Major outer capsid protein sigma 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Baboon orthoreovirus</name>
        <dbReference type="NCBI Taxonomy" id="75888"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Spinareovirinae</taxon>
            <taxon>Orthoreovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1999" name="Virology" volume="260" first="316" last="328">
            <title>Extensive sequence divergence and phylogenetic relationships between the fusogenic and nonfusogenic orthoreoviruses: a species proposal.</title>
            <authorList>
                <person name="Duncan R."/>
            </authorList>
            <dbReference type="PubMed" id="10417266"/>
            <dbReference type="DOI" id="10.1006/viro.1999.9832"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2011" name="J. Virol." volume="85" first="7483" last="7495">
            <title>Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber.</title>
            <authorList>
                <person name="Yan X."/>
                <person name="Parent K.N."/>
                <person name="Goodman R.P."/>
                <person name="Tang J."/>
                <person name="Shou J."/>
                <person name="Nibert M.L."/>
                <person name="Duncan R."/>
                <person name="Baker T.S."/>
            </authorList>
            <dbReference type="PubMed" id="21593159"/>
            <dbReference type="DOI" id="10.1128/JVI.00729-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="AF059723">
        <property type="protein sequence ID" value="AAC18128.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769554.1">
        <property type="nucleotide sequence ID" value="NC_015884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="11039977"/>
    <dbReference type="KEGG" id="vg:11039977"/>
    <dbReference type="Proteomes" id="UP000118514">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019058">
        <property type="term" value="P:viral life cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000153">
        <property type="entry name" value="Reo_capsid_sigma3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023634">
        <property type="entry name" value="Reovirus_capsid_sigma-3_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00979">
        <property type="entry name" value="Reovirus_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64465">
        <property type="entry name" value="SSF64465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC18128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000118514"/>
        </source>
    </evidence>
    <sequence length="396" mass="45246" checksum="B8428368B3F1C17B" modified="1998-08-01" version="1">MEVPLVHAHSVLEGLSSALHDVIPAYSSTYGWLGDEFAYPDVVKLGNAYVCTRCCGVLHYGEMHGGNPFIRHICKQTHSYDTSPICDLYKLSRITRRIYDAHVNILTWIANNIITDKTNENSATTPGLEIGSEIPDGYKHKSRLTDGKNFVELPLPSFPYASTSEHQYGTQVWNERFEQFFVQRELVSPRRKIRTLLRFFINVLSDEKRYYPVFIPGGEGVPKWSFDTNLYEFGLKRVNQPMPSMIPQLFNVRGTSPGNDTFFSEHHGDIKKYLLGTDLIVAPLAGNVPLIIGPLDDRYSRPMPYVRPETQKALCNNLLVRITKGWSQDHVQYTCPMGVIATEKWFSSVLPRTLYLPPMKRLMKQTDESKYSLLVRGKWEEIKASWDVQNKETSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>O72469</accession>
    <name>O72469_9REOV</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nonstructural protein sigma NS</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Baboon orthoreovirus</name>
        <dbReference type="NCBI Taxonomy" id="75888"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Spinareovirinae</taxon>
            <taxon>Orthoreovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1999" name="Virology" volume="260" first="316" last="328">
            <title>Extensive sequence divergence and phylogenetic relationships between the fusogenic and nonfusogenic orthoreoviruses: a species proposal.</title>
            <authorList>
                <person name="Duncan R."/>
            </authorList>
            <dbReference type="PubMed" id="10417266"/>
            <dbReference type="DOI" id="10.1006/viro.1999.9832"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2011" name="J. Virol." volume="85" first="7483" last="7495">
            <title>Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber.</title>
            <authorList>
                <person name="Yan X."/>
                <person name="Parent K.N."/>
                <person name="Goodman R.P."/>
                <person name="Tang J."/>
                <person name="Shou J."/>
                <person name="Nibert M.L."/>
                <person name="Duncan R."/>
                <person name="Baker T.S."/>
            </authorList>
            <dbReference type="PubMed" id="21593159"/>
            <dbReference type="DOI" id="10.1128/JVI.00729-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Protein that binds to ssRNA and may be involved in genome packaging.</text>
    </comment>
    <dbReference type="EMBL" id="AF059727">
        <property type="protein sequence ID" value="AAC18132.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769557.1">
        <property type="nucleotide sequence ID" value="NC_015886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="11039972"/>
    <dbReference type="KEGG" id="vg:11039972"/>
    <dbReference type="Proteomes" id="UP000118514">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002507">
        <property type="entry name" value="Reovirus_polyG_pol"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01518">
        <property type="entry name" value="PolyG_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC18132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000118514"/>
        </source>
    </evidence>
    <sequence length="353" mass="39102" checksum="70984BD00BAECBCB" modified="1998-08-01" version="1">MSAGLRLNVSRAVAGRKDQTFLSRLHLLKVVKNEKNELFFPNAKSVAKQLNPLFCVARDRILKKSPKVNFAEKLNKTVTDYIHQVIYDEGQFPTSRVSADILKTLLSDCYGEGFEHVANTIIPSDSYIPGALAKAFTMSLAGMAPEGDNKYIDTPVYHGAAELIVFQRGLPYTIAPVKGGTTIDRPINGVEYTLGQLANLDTIDISYGVDVRGDNVTQDSINASSRSINELPEDRLIEKLVLKVIVVLNALQLKRELDIAHEHVKDDIVGFGLQLLKQYSFLAGIDRDLCNLMISIADNKEASFNDVSRYWSEIRSGSRDLDTIGMVAKFTNGALKICQGEDVKLTIRPTRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>Q918V5</accession>
    <name>Q918V5_9REOV</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p16</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Baboon orthoreovirus</name>
        <dbReference type="NCBI Taxonomy" id="75888"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Spinareovirinae</taxon>
            <taxon>Orthoreovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1999" name="Virology" volume="260" first="316" last="328">
            <title>Extensive sequence divergence and phylogenetic relationships between the fusogenic and nonfusogenic orthoreoviruses: a species proposal.</title>
            <authorList>
                <person name="Duncan R."/>
            </authorList>
            <dbReference type="PubMed" id="10417266"/>
            <dbReference type="DOI" id="10.1006/viro.1999.9832"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2011" name="J. Virol." volume="85" first="7483" last="7495">
            <title>Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber.</title>
            <authorList>
                <person name="Yan X."/>
                <person name="Parent K.N."/>
                <person name="Goodman R.P."/>
                <person name="Tang J."/>
                <person name="Shou J."/>
                <person name="Nibert M.L."/>
                <person name="Duncan R."/>
                <person name="Baker T.S."/>
            </authorList>
            <dbReference type="PubMed" id="21593159"/>
            <dbReference type="DOI" id="10.1128/JVI.00729-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="AF406787">
        <property type="protein sequence ID" value="AAL01374.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769556.1">
        <property type="nucleotide sequence ID" value="NC_015885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="11039975"/>
    <dbReference type="KEGG" id="vg:11039975"/>
    <dbReference type="Proteomes" id="UP000118514">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAL01374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000118514"/>
        </source>
    </evidence>
    <sequence length="141" mass="16854" checksum="D56A0B71EE665C50" modified="2001-12-01" version="1">MMEETQMEVSTFEWPKSLDESLQVLCNELKGKTEWQDDMEDWMPYWIYMKHDGIAISQSRYSLLQQLAVWVWKCFDFDMCVYNIWTTWLVKHACSRCPEFDDEAFWSGVPTIIKLVIRKTMHRYAYLDDSTLADLTEQVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q918V6</accession>
    <name>Q918V6_9REOV</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane fusion protein p15</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Baboon orthoreovirus</name>
        <dbReference type="NCBI Taxonomy" id="75888"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Duplornaviricota</taxon>
            <taxon>Resentoviricetes</taxon>
            <taxon>Reovirales</taxon>
            <taxon>Reoviridae</taxon>
            <taxon>Spinareovirinae</taxon>
            <taxon>Orthoreovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1999" name="Virology" volume="260" first="316" last="328">
            <title>Extensive sequence divergence and phylogenetic relationships between the fusogenic and nonfusogenic orthoreoviruses: a species proposal.</title>
            <authorList>
                <person name="Duncan R."/>
            </authorList>
            <dbReference type="PubMed" id="10417266"/>
            <dbReference type="DOI" id="10.1006/viro.1999.9832"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2011" name="J. Virol." volume="85" first="7483" last="7495">
            <title>Virion structure of baboon reovirus, a fusogenic orthoreovirus that lacks an adhesion fiber.</title>
            <authorList>
                <person name="Yan X."/>
                <person name="Parent K.N."/>
                <person name="Goodman R.P."/>
                <person name="Tang J."/>
                <person name="Shou J."/>
                <person name="Nibert M.L."/>
                <person name="Duncan R."/>
                <person name="Baker T.S."/>
            </authorList>
            <dbReference type="PubMed" id="21593159"/>
            <dbReference type="DOI" id="10.1128/JVI.00729-11"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2011-10" db="PDB data bank">
            <title>A Myristoylated Polyproline Type II Helix Functions as a Novel Fusion Peptide During Cell-Cell Membrane Fusion Induced by the Baboon Reovirus p15 FAST Protein.</title>
            <authorList>
                <person name="Top D."/>
                <person name="Read J."/>
                <person name="Dawe S."/>
                <person name="Syvitski R."/>
                <person name="Duncan R."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY NMR OF 2-21</scope>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2014-04" db="PDB data bank">
            <title>Novel helix-loop-helix fusion-inducing lipid packing sensor (FLiPS) for cell-cell fusion.</title>
            <authorList>
                <person name="Read J."/>
                <person name="Clancy E."/>
                <person name="Sarker M."/>
                <person name="Langelaan D."/>
                <person name="Rainey J."/>
                <person name="Duncan R."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY NMR OF 68-87</scope>
    </reference>
    <dbReference type="EMBL" id="AF406787">
        <property type="protein sequence ID" value="AAL01373.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_004769555.1">
        <property type="nucleotide sequence ID" value="NC_015885.1"/>
    </dbReference>
    <dbReference type="PDB" id="2LKW">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=2-21"/>
    </dbReference>
    <dbReference type="PDB" id="2MNS">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=68-87"/>
    </dbReference>
    <dbReference type="PDBsum" id="2LKW"/>
    <dbReference type="PDBsum" id="2MNS"/>
    <dbReference type="SMR" id="Q918V6"/>
    <dbReference type="TCDB" id="1.G.13.2.1">
        <property type="family name" value="the orthoreovirus fusion-associated small transmembrane (fast) family"/>
    </dbReference>
    <dbReference type="GeneID" id="11039974"/>
    <dbReference type="KEGG" id="vg:11039974"/>
    <dbReference type="Proteomes" id="UP000118514">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAL01373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000118514"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2LKW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2MNS"/>
        </source>
    </evidence>
    <sequence length="140" mass="15223" checksum="B02BDF37E6CE6075" modified="2001-12-01" version="1">MGQRHSIVQPPAPPPNAFVEIVSSSTGIIIAVGIFAFIFSFLYKLLQWYNRKSKNKKRKEQIREQIELGLLSYGAGVASLPLLNVIAHNPGSVISATPIYKGPCTGVPNSRLLQITSGTAEENTRILNHDGRNPDGSINV</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>