<?xml version="1.0" encoding="UTF-8"?>
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 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="Swiss-Prot" created="2015-03-04" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q4VKV2</accession>
    <name>L_TUPVT</name>
    <protein>
        <recommendedName>
            <fullName>RNA-directed RNA polymerase L</fullName>
            <shortName>Protein L</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Large structural protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Replicase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Transcriptase</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName>RNA-directed RNA polymerase</fullName>
                <ecNumber evidence="2">2.7.7.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">GTP phosphohydrolase</fullName>
                <ecNumber evidence="1">3.6.1.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="5">GDP polyribonucleotidyltransferase</fullName>
                <ecNumber evidence="1">2.7.7.88</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="5">PRNTase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="5">mRNA cap methyltransferase</fullName>
                <ecNumber evidence="1">2.1.1.375</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">mRNA (guanine-N(7)-)-methyltransferase</fullName>
                <shortName evidence="1">G-N7-MTase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">mRNA (nucleoside-2'-O-)-methyltransferase</fullName>
                <shortName evidence="1">N1-2'-O-MTase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name type="primary">L</name>
    </gene>
    <organism>
        <name type="scientific">Tupaia virus (isolate Tupaia/Thailand/-/1986)</name>
        <name type="common">TUPV</name>
        <dbReference type="NCBI Taxonomy" id="1560034"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Tupavirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Tupaia</name>
        <dbReference type="NCBI Taxonomy" id="9394"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="6781" last="6790">
            <title>Characterization of the Tupaia rhabdovirus genome reveals a long open reading frame overlapping with P and a novel gene encoding a small hydrophobic protein.</title>
            <authorList>
                <person name="Springfeld C."/>
                <person name="Darai G."/>
                <person name="Cattaneo R."/>
            </authorList>
            <dbReference type="PubMed" id="15890917"/>
            <dbReference type="DOI" id="10.1128/JVI.79.11.6781-6790.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC RNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.</text>
    </comment>
    <comment type="function">
        <text evidence="1">RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:65376"/>
            <dbReference type="Rhea" id="RHEA-COMP:16797"/>
            <dbReference type="Rhea" id="RHEA-COMP:16798"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156483"/>
            <dbReference type="ChEBI" id="CHEBI:156484"/>
            <dbReference type="EC" id="2.1.1.375"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:65380"/>
            <dbReference type="Rhea" id="RHEA-COMP:16797"/>
            <dbReference type="Rhea" id="RHEA-COMP:16801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156482"/>
            <dbReference type="ChEBI" id="CHEBI:156484"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:65436"/>
            <dbReference type="Rhea" id="RHEA-COMP:16797"/>
            <dbReference type="Rhea" id="RHEA-COMP:16799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:156484"/>
            <dbReference type="ChEBI" id="CHEBI:156503"/>
            <dbReference type="EC" id="2.7.7.88"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:65440"/>
            <dbReference type="Rhea" id="RHEA-COMP:16798"/>
            <dbReference type="Rhea" id="RHEA-COMP:16801"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156482"/>
            <dbReference type="ChEBI" id="CHEBI:156483"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">May form homodimer. Interacts with the P protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">L and P are packaged asymmetrically towards the blunt end of the virus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the rhabdoviridae protein L family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="2"/>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EC" id="2.7.7.88" evidence="1"/>
    <dbReference type="EC" id="2.1.1.375" evidence="1"/>
    <dbReference type="EMBL" id="AY840978">
        <property type="protein sequence ID" value="AAX47602.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_238534.1">
        <property type="nucleotide sequence ID" value="NC_007020.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q4VKV2"/>
    <dbReference type="PRIDE" id="Q4VKV2"/>
    <dbReference type="GeneID" id="3416615"/>
    <dbReference type="KEGG" id="vg:3416615"/>
    <dbReference type="Proteomes" id="UP000029771">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019083">
        <property type="term" value="P:viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039530">
        <property type="entry name" value="L_methyltransferase_rhabdo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039736">
        <property type="entry name" value="L_poly_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026890">
        <property type="entry name" value="Mononeg_mRNAcap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014023">
        <property type="entry name" value="Mononeg_RNA_pol_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025786">
        <property type="entry name" value="Mononega_L_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017234">
        <property type="entry name" value="RNA-dir_pol_rhabdovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14314">
        <property type="entry name" value="Methyltrans_Mon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14318">
        <property type="entry name" value="Mononeg_mRNAcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00946">
        <property type="entry name" value="Mononeg_RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037546">
        <property type="entry name" value="RNA_pol_RhabdoV_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04198">
        <property type="entry name" value="paramyx_RNAcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50526">
        <property type="entry name" value="RDRP_SSRNA_NEG_NONSEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51590">
        <property type="entry name" value="SAM_MT_MNV_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0506">mRNA capping</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0693">Viral RNA replication</keyword>
    <keyword id="KW-1195">Viral transcription</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000432053" description="RNA-directed RNA polymerase L">
        <location>
            <begin position="1"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="domain" description="RdRp catalytic" evidence="3">
        <location>
            <begin position="594"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Mononegavirus-type SAM-dependent 2'-O-MTase" evidence="4">
        <location>
            <begin position="1635"/>
            <end position="1832"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P03523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P28887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="2107" mass="241782" checksum="BBA3684C7B8A872C" modified="2005-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-03-04" modified="2022-02-23" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q4VKV3</accession>
    <name>GLYCO_TUPVT</name>
    <protein>
        <recommendedName>
            <fullName>Glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">G</name>
    </gene>
    <organism>
        <name type="scientific">Tupaia virus (isolate Tupaia/Thailand/-/1986)</name>
        <name type="common">TUPV</name>
        <dbReference type="NCBI Taxonomy" id="1560034"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Tupavirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Tupaia</name>
        <dbReference type="NCBI Taxonomy" id="9394"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="6781" last="6790">
            <title>Characterization of the Tupaia rhabdovirus genome reveals a long open reading frame overlapping with P and a novel gene encoding a small hydrophobic protein.</title>
            <authorList>
                <person name="Springfeld C."/>
                <person name="Darai G."/>
                <person name="Cattaneo R."/>
            </authorList>
            <dbReference type="PubMed" id="15890917"/>
            <dbReference type="DOI" id="10.1128/JVI.79.11.6781-6790.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC RNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Attaches the virus to host receptors, inducing clathrin-dependent endocytosis of the virion.</text>
    </comment>
    <comment type="function">
        <text evidence="2">In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and endosomal membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Virion membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Glycosylated by host.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vesiculovirus glycoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY840978">
        <property type="protein sequence ID" value="AAX47601.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_238533.1">
        <property type="nucleotide sequence ID" value="NC_007020.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q4VKV3"/>
    <dbReference type="GeneID" id="3416614"/>
    <dbReference type="KEGG" id="vg:3416614"/>
    <dbReference type="Proteomes" id="UP000029771">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001903">
        <property type="entry name" value="Rhabd_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00974">
        <property type="entry name" value="Rhabdo_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1165">Clathrin-mediated endocytosis of virus by host</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-1170">Fusion of virus membrane with host endosomal membrane</keyword>
    <keyword id="KW-1168">Fusion of virus membrane with host membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-1161">Viral attachment to host cell</keyword>
    <keyword id="KW-0261">Viral envelope protein</keyword>
    <keyword id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-1164">Virus endocytosis by host</keyword>
    <keyword id="KW-1160">Virus entry into host cell</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000432049" description="Glycoprotein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="topological domain" description="Virion surface" evidence="3">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="3">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="44"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="171"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="531" mass="59336" checksum="BF8C7D085F5571BB" modified="2005-07-05" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-03-04" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>Q4VKV4</accession>
    <name>SH_TUPVT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small hydrophobic protein</fullName>
            <shortName evidence="2">Protein SH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SH</name>
    </gene>
    <organism>
        <name type="scientific">Tupaia virus (isolate Tupaia/Thailand/-/1986)</name>
        <name type="common">TUPV</name>
        <dbReference type="NCBI Taxonomy" id="1560034"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Tupavirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Tupaia</name>
        <dbReference type="NCBI Taxonomy" id="9394"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="6781" last="6790">
            <title>Characterization of the Tupaia rhabdovirus genome reveals a long open reading frame overlapping with P and a novel gene encoding a small hydrophobic protein.</title>
            <authorList>
                <person name="Springfeld C."/>
                <person name="Darai G."/>
                <person name="Cattaneo R."/>
            </authorList>
            <dbReference type="PubMed" id="15890917"/>
            <dbReference type="DOI" id="10.1128/JVI.79.11.6781-6790.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC RNA / MRNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY840978">
        <property type="protein sequence ID" value="AAX47600.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_238532.1">
        <property type="nucleotide sequence ID" value="NC_007020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3416613"/>
    <dbReference type="KEGG" id="vg:3416613"/>
    <dbReference type="Proteomes" id="UP000029771">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000432060" description="Small hydrophobic protein">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="15890917"/>
        </source>
    </evidence>
    <sequence length="93" mass="10630" checksum="90DD6B38B1191861" modified="2005-07-05" version="1">MITTLIIIGAAFLVGPRTFKFVLAYLLGYYNAFGPPLQIVQFMVWLIIIYFPKKFFSLGWYFCHDAFSSYFGDPNGGQLPVSTKFHSLTDMID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-03-04" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q4VKV5</accession>
    <name>MATRX_TUPVT</name>
    <protein>
        <recommendedName>
            <fullName>Matrix protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">M</name>
    </gene>
    <organism>
        <name type="scientific">Tupaia virus (isolate Tupaia/Thailand/-/1986)</name>
        <name type="common">TUPV</name>
        <dbReference type="NCBI Taxonomy" id="1560034"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Tupavirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Tupaia</name>
        <dbReference type="NCBI Taxonomy" id="9394"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="6781" last="6790">
            <title>Characterization of the Tupaia rhabdovirus genome reveals a long open reading frame overlapping with P and a novel gene encoding a small hydrophobic protein.</title>
            <authorList>
                <person name="Springfeld C."/>
                <person name="Darai G."/>
                <person name="Cattaneo R."/>
            </authorList>
            <dbReference type="PubMed" id="15890917"/>
            <dbReference type="DOI" id="10.1128/JVI.79.11.6781-6790.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC RNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a major role in assembly and budding of virion, by recruiting cellular partners of the ESCRT complexes that play a key role in releasing the budding particle from the host membrane. Condensates the ribonucleocapsid core during virus assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homomultimer. Interacts with viral nucleocapsid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY840978">
        <property type="protein sequence ID" value="AAX47599.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_238531.1">
        <property type="nucleotide sequence ID" value="NC_007020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3416612"/>
    <dbReference type="KEGG" id="vg:3416612"/>
    <dbReference type="Proteomes" id="UP000029771">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1198">Viral budding</keyword>
    <keyword id="KW-1187">Viral budding via the host ESCRT complexes</keyword>
    <keyword id="KW-0468">Viral matrix protein</keyword>
    <keyword id="KW-1188">Viral release from host cell</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000432062" description="Matrix protein">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P03519"/>
        </source>
    </evidence>
    <sequence length="200" mass="22433" checksum="E09BAE57968496DA" modified="2005-07-05" version="1">MLRWFSFGSNEGSEVAGNGWSVKPIGNMSIKKDDPVGFPQGYQCLLKVIIQLEKKDPTKSDVSELIAGWVKRYSGPHLLERLIKALIILTVPKLSRENIDNHVKLGGLFEGQVTFHFSSRDLIPTKYLSYATSIRTTVKGIYSYLSIEAELNPSSHQGTSVAKLLRASDVAKYYDNTLQSIFSQFEIKNVTITDDQIIFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-03-04" modified="2022-02-23" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>Q4VKV6</accession>
    <name>C_TUPVT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C</name>
    </gene>
    <organism>
        <name type="scientific">Tupaia virus (isolate Tupaia/Thailand/-/1986)</name>
        <name type="common">TUPV</name>
        <dbReference type="NCBI Taxonomy" id="1560034"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Tupavirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Tupaia</name>
        <dbReference type="NCBI Taxonomy" id="9394"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="6781" last="6790">
            <title>Characterization of the Tupaia rhabdovirus genome reveals a long open reading frame overlapping with P and a novel gene encoding a small hydrophobic protein.</title>
            <authorList>
                <person name="Springfeld C."/>
                <person name="Darai G."/>
                <person name="Cattaneo R."/>
            </authorList>
            <dbReference type="PubMed" id="15890917"/>
            <dbReference type="DOI" id="10.1128/JVI.79.11.6781-6790.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC RNA / MRNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Does not belong to rhabdoviridae replication core genes, and is specific to sigma virus: protein C is presumably involved in host-virus interactions.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>Q4VKV6-1</id>
            <name>Protein C</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q4VKV7-1</id>
            <name>Phosphoprotein</name>
            <sequence type="external"/>
        </isoform>
    </comment>
    <dbReference type="EMBL" id="AY840978">
        <property type="protein sequence ID" value="AAX47598.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_238530.1">
        <property type="nucleotide sequence ID" value="NC_007020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3416611"/>
    <dbReference type="Proteomes" id="UP000029771">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0024">Alternative initiation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000432061" description="Protein C">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="15890917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="221" mass="25780" checksum="8340E09B51FAB60A" modified="2005-07-05" version="1">MTSQRFQELLKNVKTNLGSVWVEFRSSVEERLKHPHIWKIIDREQLATILMFFLGIPKMFRLSQNMKIRQMRNMRKPGVMEMTPDTNQTEQPCPSQMTNTETSKEPESVSLNSSTKDGDLDPNKQMKNLRRDSSSSQESADLEEDHRMLGGRMRMIFKRRQGMRKKSQSLSHLRSQAVYQDTTEAAISPSTWKSFWPPQLRLRDDNSWSSVNLSQTDPTKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-03-04" modified="2022-02-23" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>Q4VKV7</accession>
    <name>PHOSP_TUPVT</name>
    <protein>
        <recommendedName>
            <fullName>Phosphoprotein</fullName>
            <shortName>P protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">P</name>
    </gene>
    <organism>
        <name type="scientific">Tupaia virus (isolate Tupaia/Thailand/-/1986)</name>
        <name type="common">TUPV</name>
        <dbReference type="NCBI Taxonomy" id="1560034"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Tupavirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Tupaia</name>
        <dbReference type="NCBI Taxonomy" id="9394"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="6781" last="6790">
            <title>Characterization of the Tupaia rhabdovirus genome reveals a long open reading frame overlapping with P and a novel gene encoding a small hydrophobic protein.</title>
            <authorList>
                <person name="Springfeld C."/>
                <person name="Darai G."/>
                <person name="Cattaneo R."/>
            </authorList>
            <dbReference type="PubMed" id="15890917"/>
            <dbReference type="DOI" id="10.1128/JVI.79.11.6781-6790.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC RNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template. May act as a chaperone for newly synthesized free N protein, so-called N(0). Plays a role in virion assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer. This trimer is stabilized by binding to the L protein. Binds N(0), and N in ribonucleocapsid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>Q4VKV7-1</id>
            <name>Phosphoprotein</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q4VKV6-1</id>
            <name>Protein C</name>
            <sequence type="external"/>
        </isoform>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by host kinases. Phosphorylation play an important role in facilitating trimerization and possibly P-L complex formation.</text>
    </comment>
    <dbReference type="EMBL" id="AY840978">
        <property type="protein sequence ID" value="AAX47597.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_238529.1">
        <property type="nucleotide sequence ID" value="NC_007020.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3416611"/>
    <dbReference type="KEGG" id="vg:3416611"/>
    <dbReference type="Proteomes" id="UP000029771">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0024">Alternative initiation</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0693">Viral RNA replication</keyword>
    <keyword id="KW-1195">Viral transcription</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000432069" description="Phosphoprotein">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="337" mass="37286" checksum="A745DD13E4943992" modified="2005-07-05" version="1">MTDPKKISRVALKGYDLTKVSRALEECEDQPGVRVGGVQIVSGGEAEAPAHLEDNRQGAIGDNFDVFSRDSKNVQIVTEHEDSSDEEYEEARSYGDDSGHQPNRAAVPFADDEYGDFKRARERLPQLFHEGWGFGSQQANEESSEGLQQQSGECGSGGGSSNAGGKDEDDLQEKTGHEKEKSVIVPPKESGSVSGYHGSCDIPFNMEEFLASPATTQRRQLLELCQLIADRSNEELIFFPWGFNLVKRKVHRVEPQQPVAVSHRFTWEDFQLKLKAGFTLIHKKTKAPVVLNSSSYNLGSVPEGGISLSPDDTELSVLIKCLRYLGLYKFLATQIEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-03-04" modified="2022-02-23" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q4VKV8</accession>
    <name>NCAP_TUPVT</name>
    <protein>
        <recommendedName>
            <fullName>Nucleoprotein</fullName>
            <shortName>NP</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Nucleocapsid protein</fullName>
            <shortName>Protein N</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">N</name>
    </gene>
    <organism>
        <name type="scientific">Tupaia virus (isolate Tupaia/Thailand/-/1986)</name>
        <name type="common">TUPV</name>
        <dbReference type="NCBI Taxonomy" id="1560034"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Rhabdoviridae</taxon>
            <taxon>Alpharhabdovirinae</taxon>
            <taxon>Tupavirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Tupaia</name>
        <dbReference type="NCBI Taxonomy" id="9394"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="6781" last="6790">
            <title>Characterization of the Tupaia rhabdovirus genome reveals a long open reading frame overlapping with P and a novel gene encoding a small hydrophobic protein.</title>
            <authorList>
                <person name="Springfeld C."/>
                <person name="Darai G."/>
                <person name="Cattaneo R."/>
            </authorList>
            <dbReference type="PubMed" id="15890917"/>
            <dbReference type="DOI" id="10.1128/JVI.79.11.6781-6790.2005"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC RNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Nucleocapsid assembly is concommitant with replication, therefore viral replication depends on the intracellular concentration of free N, termed N(0). All replicative products are resistant to nucleases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. N in nucleocapsid binds the P protein and thereby positions the polymerase on the template. Interaction of N(0) with the P protein prevents the uncontrolled aggregation of N(0).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Host cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">The nucleocapsid is synthesized in the cytoplasm, and is subsequently transported via microtubules to the cell periphery.</text>
    </comment>
    <dbReference type="EMBL" id="AY840978">
        <property type="protein sequence ID" value="AAX47596.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_238528.1">
        <property type="nucleotide sequence ID" value="NC_007020.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q4VKV8"/>
    <dbReference type="GeneID" id="3416610"/>
    <dbReference type="KEGG" id="vg:3416610"/>
    <dbReference type="Proteomes" id="UP000029771">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000448">
        <property type="entry name" value="Rhabdo_ncapsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023331">
        <property type="entry name" value="Rhabdovirus_ncapsid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023330">
        <property type="entry name" value="Rhabdovirus_ncapsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035961">
        <property type="entry name" value="Rhabdovirus_nucleoprotein-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00945">
        <property type="entry name" value="Rhabdo_ncap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140809">
        <property type="entry name" value="SSF140809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0167">Capsid protein</keyword>
    <keyword id="KW-1139">Helical capsid protein</keyword>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0543">Viral nucleoprotein</keyword>
    <keyword id="KW-0693">Viral RNA replication</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000432065" description="Nucleoprotein">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P03521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="430" mass="49107" checksum="474B43AB397AA584" modified="2005-07-05" version="1">MSLSRLYSKKTQSSYNATAPLDRDPPEYPGDAFKKSRNKPTLTRPKSNLSLDDARCMIKGQIQNGSVDIELAKHYLILVLEQITEDNSDDWTSFGVQILSRTERGRPLCMVNIQLDDKDKTFDSQVKDSTATVEDDLWMTTYLLAIYRIGRATNKNYQTQLIDELNKLLATFPGDYVPMVQALQAFDSWPNDPNYCKLVACVDMFFSRFKKSKWAILRFGTISSRYRDCAALTALNHFSRLLGVDLVDALEWSFVGRVSDEIEQMLKPDQELDKVDSYTPYMIDLGISKASPYSTVRNPAWHLFCHTVGSLMMSRRSINARHLEAPDQSNILSNAELIVFVFETRIKWLKNFRKLDSVDASDQLDQVAPVVLGTKDLPNTTNADDWFSWMKLNNFELPDECGRYVSKLAKKLKDSREGSVGQFVYLRLGD</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>