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        <citation type="journal article" date="1989" name="J. Gen. Virol." volume="70" first="1151" last="1160">
            <title>Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase.</title>
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        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
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                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
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        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="714" last="722">
            <title>Identification, cloning, and expression of the major capsid protein gene of human herpesvirus 6.</title>
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                <person name="Littler E."/>
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                <person name="Arrand J.R."/>
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            <title>The genome of human herpesvirus 6: Maps of unit-length and concatemeric genomes for nine restriction endonucleases.</title>
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                <person name="Martin M."/>
                <person name="Thomson B.J."/>
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                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
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                <person name="Teo I."/>
                <person name="Jones M.D."/>
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        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="2884" last="2894">
            <title>Identification, characterization, and sequence analysis of a cDNA encoding a phosphoprotein of human herpesvirus 6.</title>
            <authorList>
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        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="4670" last="4680">
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                <person name="Teo I.A."/>
                <person name="Griffin B.E."/>
                <person name="Jones M.D."/>
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        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="5381" last="5390">
            <title>Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6.</title>
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                <person name="Newman C."/>
                <person name="Honess R.W."/>
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        <citation type="journal article" date="1991" name="Nature" volume="351" first="78" last="80">
            <title>Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6.</title>
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                <person name="Thomson B.J."/>
                <person name="Efstathiou S."/>
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            <dbReference type="DOI" id="10.1038/351078a0"/>
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        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
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                <person name="Gompels U.A."/>
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                <person name="Arrand J.R."/>
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        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1649" last="1660">
            <title>The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family.</title>
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                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
            </authorList>
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    <reference evidence="2 3" key="11">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
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                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
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    <reference evidence="2 3" key="12">
        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="1564" last="1570">
            <title>Identification and characterization of a human herpesvirus 6 gene segment that trans activates the human immunodeficiency virus type 1 promoter.</title>
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                <person name="Wood C."/>
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            <dbReference type="PubMed" id="1310766"/>
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        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="3918" last="3924">
            <title>Gene for the major antigenic structural protein (p100) of human herpesvirus 6.</title>
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                <person name="Neipel F."/>
                <person name="Ellinger K."/>
                <person name="Fleckenstein B."/>
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        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="495" last="500">
            <title>The glycoprotein B homologue of human herpesvirus 6.</title>
            <authorList>
                <person name="Ellinger K."/>
                <person name="Neipel F."/>
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                <person name="Campadelli-Fiume G."/>
                <person name="Fleckenstein B."/>
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            <dbReference type="PubMed" id="8383182"/>
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        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="613" last="622">
            <title>Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients.</title>
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                <person name="Gompels U.A."/>
                <person name="Carrigan D.R."/>
                <person name="Carss A.L."/>
                <person name="Arno J."/>
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            <dbReference type="PubMed" id="8385692"/>
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    <reference evidence="2 3" key="16">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="1847" last="1857">
            <title>Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein.</title>
            <authorList>
                <person name="Liu D.X."/>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lelliott C."/>
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            <dbReference type="PubMed" id="8397282"/>
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    <reference evidence="2 3" key="17">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="4611" last="4620">
            <title>Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies.</title>
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                <person name="Berneman Z.N."/>
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                <person name="Chang C.K."/>
                <person name="Tirwatnapong S."/>
                <person name="Chandran B."/>
            </authorList>
            <dbReference type="PubMed" id="7687301"/>
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    <reference evidence="2 3" key="18">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="7680" last="7683">
            <title>Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29.</title>
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                <person name="Dewhurst S."/>
                <person name="Dollard S.C."/>
                <person name="Pellett P.E."/>
                <person name="Dambaugh T.R."/>
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        <citation type="journal article" date="1993" name="J. Virol." volume="194" first="380" last="386">
            <title>Identification and characterization of glycoprotein gH of human herpesvirus-6.</title>
            <authorList>
                <person name="Qian G."/>
                <person name="Wood C."/>
                <person name="Chandran B."/>
            </authorList>
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        <citation type="journal article" date="1993" name="Virology" volume="195" first="521" last="531">
            <title>A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope.</title>
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                <person name="Pellett P.E."/>
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                <person name="Dominguez G."/>
                <person name="Black J.B."/>
                <person name="Anton E."/>
                <person name="Greenamoyer C."/>
                <person name="Dambaugh T.R."/>
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        <citation type="journal article" date="1993" name="Virology" volume="197" first="12" last="22">
            <title>Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the target for neutralizing monoclonal antibodies.</title>
            <authorList>
                <person name="Liu D.X."/>
                <person name="Gompels U.A."/>
                <person name="Foa-Tomasi L."/>
                <person name="Campadelli-Fiume G."/>
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        <citation type="journal article" date="1993" name="Virology" volume="197" first="449" last="454">
            <title>Identification and analysis of the transport/capsid assembly protein (tp/cap) gene of human herpesvirus-6 (HHV6).</title>
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                <person name="Teo I."/>
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            <dbReference type="DOI" id="10.1006/viro.1993.1610"/>
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            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
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            <title>Structure and transcription of an immediate-early region in the human herpesvirus 6 genome.</title>
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                <person name="Schreiner D."/>
                <person name="Fleckenstein B."/>
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            <dbReference type="PubMed" id="8151768"/>
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            <title>Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini.</title>
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                <person name="Thomson B.J."/>
                <person name="Dewhurst S."/>
                <person name="Gray D."/>
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            <title>Alphaherpesvirus origin-binding protein homolog encoded by human herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that are similar to ori regions of alphaherpesviruses.</title>
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                <person name="Rapp J.C."/>
                <person name="Pellett P.E."/>
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            <dbReference type="PubMed" id="8207791"/>
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        <citation type="journal article" date="1994" name="Oncogene" volume="9" first="1167" last="1175">
            <title>A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1.</title>
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                <person name="Frenkel N."/>
                <person name="Rosenthal L.J."/>
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        <citation type="journal article" date="1994" name="Virology" volume="199" first="311" last="322">
            <title>trans-activation of the HIV promoter by a cDNA and its genomic clones of human herpesvirus-6.</title>
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                <person name="Zhou Y."/>
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                <person name="Chandran B."/>
                <person name="Wood C."/>
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            <title>Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expression.</title>
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                <person name="Thomson B.J."/>
                <person name="Weindler F.W."/>
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                <person name="Helbronn R."/>
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            <title>Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication.</title>
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        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">U1102</strain>
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        <citation type="journal article" date="2017" name="Viruses" volume="10" first="E16" last="E16">
            <title>Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes.</title>
            <authorList>
                <person name="Tweedy J.G."/>
                <person name="Escriva E."/>
                <person name="Topf M."/>
                <person name="Gompels U.A."/>
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        <citation type="journal article" date="1989" name="J. Gen. Virol." volume="70" first="1151" last="1160">
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            <authorList>
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                <person name="Lawrence G.L."/>
                <person name="Barrell B.G."/>
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        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
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                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
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        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="714" last="722">
            <title>Identification, cloning, and expression of the major capsid protein gene of human herpesvirus 6.</title>
            <authorList>
                <person name="Littler E."/>
                <person name="Lawrence G."/>
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                <person name="Barrell B.G."/>
                <person name="Arrand J.R."/>
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            <dbReference type="PubMed" id="2153237"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="1991" name="J. Gen. Virol." volume="72" first="157" last="168">
            <title>The genome of human herpesvirus 6: Maps of unit-length and concatemeric genomes for nine restriction endonucleases.</title>
            <authorList>
                <person name="Martin M."/>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
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                <person name="Gompels U.A."/>
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                <person name="Teo I."/>
                <person name="Jones M.D."/>
            </authorList>
            <dbReference type="PubMed" id="1846644"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Uganda-1102</strain>
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        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="2884" last="2894">
            <title>Identification, characterization, and sequence analysis of a cDNA encoding a phosphoprotein of human herpesvirus 6.</title>
            <authorList>
                <person name="Chang C.K."/>
                <person name="Balachandran N."/>
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            <dbReference type="PubMed" id="1851860"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Uganda-1102</strain>
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        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="4670" last="4680">
            <title>Characterization of the DNA polymerase gene of human herpesvirus 6.</title>
            <authorList>
                <person name="Teo I.A."/>
                <person name="Griffin B.E."/>
                <person name="Jones M.D."/>
            </authorList>
            <dbReference type="PubMed" id="1651403"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
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        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="5381" last="5390">
            <title>Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6.</title>
            <authorList>
                <person name="Martin M.E.D."/>
                <person name="Nicholas J."/>
                <person name="Thomson B.J."/>
                <person name="Newman C."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1654446"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">Uganda-1102</strain>
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        <citation type="journal article" date="1991" name="Nature" volume="351" first="78" last="80">
            <title>Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Efstathiou S."/>
                <person name="Honess R.W."/>
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            <dbReference type="DOI" id="10.1038/351078a0"/>
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            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="9">
        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carss A.L."/>
                <person name="Sun N."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1333836"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="10">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1649" last="1660">
            <title>The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1321205"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="11">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
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                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="12">
        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="1564" last="1570">
            <title>Identification and characterization of a human herpesvirus 6 gene segment that trans activates the human immunodeficiency virus type 1 promoter.</title>
            <authorList>
                <person name="Geng Y."/>
                <person name="Chandran B."/>
                <person name="Josephs S.F."/>
                <person name="Wood C."/>
            </authorList>
            <dbReference type="PubMed" id="1310766"/>
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        <source>
            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="13">
        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="3918" last="3924">
            <title>Gene for the major antigenic structural protein (p100) of human herpesvirus 6.</title>
            <authorList>
                <person name="Neipel F."/>
                <person name="Ellinger K."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="1374813"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
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    </reference>
    <reference evidence="9 10" key="14">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="495" last="500">
            <title>The glycoprotein B homologue of human herpesvirus 6.</title>
            <authorList>
                <person name="Ellinger K."/>
                <person name="Neipel F."/>
                <person name="Foa-Tomasi L."/>
                <person name="Campadelli-Fiume G."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="8383182"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="15">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="613" last="622">
            <title>Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carrigan D.R."/>
                <person name="Carss A.L."/>
                <person name="Arno J."/>
            </authorList>
            <dbReference type="PubMed" id="8385692"/>
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            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="16">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="1847" last="1857">
            <title>Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein.</title>
            <authorList>
                <person name="Liu D.X."/>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lelliott C."/>
            </authorList>
            <dbReference type="PubMed" id="8397282"/>
        </citation>
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        <source>
            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="17">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="4611" last="4620">
            <title>Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies.</title>
            <authorList>
                <person name="Pfeiffer B."/>
                <person name="Berneman Z.N."/>
                <person name="Neipel F."/>
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                <person name="Tirwatnapong S."/>
                <person name="Chandran B."/>
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            <dbReference type="PubMed" id="7687301"/>
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            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="18">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="7680" last="7683">
            <title>Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29.</title>
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                <person name="Dewhurst S."/>
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                <person name="Pellett P.E."/>
                <person name="Dambaugh T.R."/>
            </authorList>
            <dbReference type="PubMed" id="8230490"/>
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            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="19">
        <citation type="journal article" date="1993" name="Virology" volume="195" first="521" last="531">
            <title>A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope.</title>
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            </authorList>
            <dbReference type="PubMed" id="7687803"/>
            <dbReference type="DOI" id="10.1006/viro.1993.1403"/>
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            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="20">
        <citation type="journal article" date="1993" name="Virology" volume="197" first="12" last="22">
            <title>Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the target for neutralizing monoclonal antibodies.</title>
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            </authorList>
            <dbReference type="PubMed" id="7692666"/>
            <dbReference type="DOI" id="10.1006/viro.1993.1562"/>
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            <strain evidence="10">Uganda-1102</strain>
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    <reference evidence="9 10" key="21">
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            <title>Identification and analysis of the transport/capsid assembly protein (tp/cap) gene of human herpesvirus-6 (HHV6).</title>
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                <person name="Teo I."/>
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            <dbReference type="DOI" id="10.1006/viro.1993.1610"/>
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            <strain evidence="10">Uganda-1102</strain>
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            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
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                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
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            <title>Structure and transcription of an immediate-early region in the human herpesvirus 6 genome.</title>
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                <person name="Schreiner D."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="8151768"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
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                <person name="Gray D."/>
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            <dbReference type="PubMed" id="8151770"/>
        </citation>
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            <strain evidence="10">Uganda-1102</strain>
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    </reference>
    <reference evidence="9 10" key="25">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="4126" last="4136">
            <title>Alphaherpesvirus origin-binding protein homolog encoded by human herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that are similar to ori regions of alphaherpesviruses.</title>
            <authorList>
                <person name="Inoue N."/>
                <person name="Dambaugh T.R."/>
                <person name="Rapp J.C."/>
                <person name="Pellett P.E."/>
            </authorList>
            <dbReference type="PubMed" id="8207791"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="26">
        <citation type="journal article" date="1994" name="Oncogene" volume="9" first="1167" last="1175">
            <title>A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1.</title>
            <authorList>
                <person name="Thompson J."/>
                <person name="Choudhury S."/>
                <person name="Kashanchi F."/>
                <person name="Doniger J."/>
                <person name="Berneman Z."/>
                <person name="Frenkel N."/>
                <person name="Rosenthal L.J."/>
            </authorList>
            <dbReference type="PubMed" id="8134119"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="27">
        <citation type="journal article" date="1994" name="Virology" volume="199" first="311" last="322">
            <title>trans-activation of the HIV promoter by a cDNA and its genomic clones of human herpesvirus-6.</title>
            <authorList>
                <person name="Zhou Y."/>
                <person name="Chang C.K."/>
                <person name="Qian G."/>
                <person name="Chandran B."/>
                <person name="Wood C."/>
            </authorList>
            <dbReference type="PubMed" id="8122364"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1129"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="28">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="304" last="311">
            <title>Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expression.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Weindler F.W."/>
                <person name="Gray D."/>
                <person name="Schwaab V."/>
                <person name="Helbronn R."/>
            </authorList>
            <dbReference type="PubMed" id="8091661"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1535"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="29">
        <citation type="journal article" date="1995" name="J. Gen. Virol." volume="76" first="451" last="458">
            <title>Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7844567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="30">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Uganda-1102</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Host nucleus</location>
        </subcellularLocation>
        <text evidence="6">Responsible for the nuclear localization of the two others subunits TRM1 and TRM2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the herpesviridae TRM3 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="SPC53501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04013">
        <property type="entry name" value="HSV_TRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003498">
        <property type="entry name" value="DNA_pack_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038435">
        <property type="entry name" value="DNA_pack_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003499">
        <property type="entry name" value="DNA_pack_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033663">
        <property type="entry name" value="HSV_TRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02499">
        <property type="entry name" value="DNA_pack_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02500">
        <property type="entry name" value="DNA_pack_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 6" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="2 6" id="KW-1188">Viral release from host cell</keyword>
    <feature type="domain" description="DNA_pack_N" evidence="8">
        <location>
            <begin position="45"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pack_C" evidence="7">
        <location>
            <begin position="321"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Walker A motif" evidence="6">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Walker B motif" evidence="6">
        <location>
            <begin position="300"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="For ATPase activity" evidence="6">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="6">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="6">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="6">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="SPC53501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000009295"/>
        </source>
    </evidence>
    <sequence length="666" mass="76232" checksum="2C5D2AA0FF784E78" modified="2018-04-25" version="1">MLRTCDITHIKNNYEAIIWKGERDCSTISTKYPNSAIFYKKRFIMLTPELGFAHSYNQQVKPLYTFCEKQRHLKNRKPLTILPSLSHKLQEMKFLPASDKSFESQYTEFLESFKILYREPLFLQIDGFIKDFRKWIKGEFNDFGDTRKIQLEPFQKNILIHVIFFIAVTKLPALANRVINYLTHVFDIEFVNESTLNTLKQKTNVFLVPRRHGKTWFIVPIISFLLKNIEGISIGYVAHQKHVSHFVMKEVEFKCRRMFPEKTITCLDNVITIDHQNIKSTALFASCYNTHSIRGQSFNLLIVDESHFIKKDAFSTILGFLPQASTKILFISSTNSGNHSTSFLMKLNNSPFEMLSVVSYVCEDHAHMLNERGNATACSCYRLHKPKFISINAEVKKTANLFLEGAFIHEIMGGATCNVINDVLITEQGQTEFEFFRYSTINKNLIPFLGKDLYVYLDPAYTGNRRASGTGIAAIGTYLDQYIVYGMEHYFLESLMTSSDTAIAECAAHMILSILDLHPFFTEVKIIIEGNSNQASAVKIACIIKENITANKSIQVTFFHTPDQNQIAQPFYLLGKEKKLAVEFFISNFNSGNIKASQELISFTIKITYDPVEYALEQIRNIHQISVNNYITYSAKKQACSDDLIIAIIMAIYVCSGNSSASFREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-04-25" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A2N9DYY9</accession>
    <name>A0A2N9DYY9_HHV6U</name>
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        <submittedName>
            <fullName evidence="2">Capsid scaffold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">U53.5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1989" name="J. Gen. Virol." volume="70" first="1151" last="1160">
            <title>Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Lawrence G.L."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2543772"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="714" last="722">
            <title>Identification, cloning, and expression of the major capsid protein gene of human herpesvirus 6.</title>
            <authorList>
                <person name="Littler E."/>
                <person name="Lawrence G."/>
                <person name="Liu M.Y."/>
                <person name="Barrell B.G."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="2153237"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="4">
        <citation type="journal article" date="1991" name="J. Gen. Virol." volume="72" first="157" last="168">
            <title>The genome of human herpesvirus 6: Maps of unit-length and concatemeric genomes for nine restriction endonucleases.</title>
            <authorList>
                <person name="Martin M."/>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Liu M.Y."/>
                <person name="Littler E."/>
                <person name="Arrand J.R."/>
                <person name="Teo I."/>
                <person name="Jones M.D."/>
            </authorList>
            <dbReference type="PubMed" id="1846644"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="5">
        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="2884" last="2894">
            <title>Identification, characterization, and sequence analysis of a cDNA encoding a phosphoprotein of human herpesvirus 6.</title>
            <authorList>
                <person name="Chang C.K."/>
                <person name="Balachandran N."/>
            </authorList>
            <dbReference type="PubMed" id="1851860"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="6">
        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="4670" last="4680">
            <title>Characterization of the DNA polymerase gene of human herpesvirus 6.</title>
            <authorList>
                <person name="Teo I.A."/>
                <person name="Griffin B.E."/>
                <person name="Jones M.D."/>
            </authorList>
            <dbReference type="PubMed" id="1651403"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="7">
        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="5381" last="5390">
            <title>Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6.</title>
            <authorList>
                <person name="Martin M.E.D."/>
                <person name="Nicholas J."/>
                <person name="Thomson B.J."/>
                <person name="Newman C."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1654446"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="8">
        <citation type="journal article" date="1991" name="Nature" volume="351" first="78" last="80">
            <title>Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Efstathiou S."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1851252"/>
            <dbReference type="DOI" id="10.1038/351078a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="9">
        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carss A.L."/>
                <person name="Sun N."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1333836"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="10">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1649" last="1660">
            <title>The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1321205"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="11">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="12">
        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="1564" last="1570">
            <title>Identification and characterization of a human herpesvirus 6 gene segment that trans activates the human immunodeficiency virus type 1 promoter.</title>
            <authorList>
                <person name="Geng Y."/>
                <person name="Chandran B."/>
                <person name="Josephs S.F."/>
                <person name="Wood C."/>
            </authorList>
            <dbReference type="PubMed" id="1310766"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="13">
        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="3918" last="3924">
            <title>Gene for the major antigenic structural protein (p100) of human herpesvirus 6.</title>
            <authorList>
                <person name="Neipel F."/>
                <person name="Ellinger K."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="1374813"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="14">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="495" last="500">
            <title>The glycoprotein B homologue of human herpesvirus 6.</title>
            <authorList>
                <person name="Ellinger K."/>
                <person name="Neipel F."/>
                <person name="Foa-Tomasi L."/>
                <person name="Campadelli-Fiume G."/>
                <person name="Fleckenstein B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="DOI" id="10.1006/viro.1994.1129"/>
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                <person name="Gompels U.A."/>
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                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
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                <person name="Fleckenstein B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 3" key="18">
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    <reference evidence="2 3" key="19">
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            <dbReference type="DOI" id="10.1006/viro.1993.1403"/>
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    <reference evidence="2 3" key="20">
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            <dbReference type="DOI" id="10.1006/viro.1993.1562"/>
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            <strain evidence="3">Uganda-1102</strain>
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    <reference evidence="2 3" key="21">
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            <dbReference type="DOI" id="10.1006/viro.1993.1610"/>
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        <source>
            <strain evidence="3">Uganda-1102</strain>
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    </reference>
    <reference evidence="2 3" key="22">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
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    </reference>
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            <dbReference type="PubMed" id="8151768"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
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    </reference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
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    </reference>
    <reference evidence="2 3" key="25">
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                <person name="Pellett P.E."/>
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            <dbReference type="PubMed" id="8207791"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
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    </reference>
    <reference evidence="2 3" key="26">
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            <dbReference type="PubMed" id="8134119"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
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    <reference evidence="2 3" key="27">
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            </authorList>
            <dbReference type="PubMed" id="8122364"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1129"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">Uganda-1102</strain>
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    <reference evidence="2 3" key="28">
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                <person name="Thomson B.J."/>
                <person name="Weindler F.W."/>
                <person name="Gray D."/>
                <person name="Schwaab V."/>
                <person name="Helbronn R."/>
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            <dbReference type="DOI" id="10.1006/viro.1994.1535"/>
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    <reference evidence="2 3" key="29">
        <citation type="journal article" date="1995" name="J. Gen. Virol." volume="76" first="451" last="458">
            <title>Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Macaulay H.A."/>
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        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
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        <citation type="journal article" date="1989" name="J. Gen. Virol." volume="70" first="1151" last="1160">
            <title>Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase.</title>
            <authorList>
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                <person name="Lawrence G.L."/>
                <person name="Barrell B.G."/>
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                <person name="Barrell B.G."/>
                <person name="Arrand J.R."/>
            </authorList>
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                <person name="Teo I."/>
                <person name="Jones M.D."/>
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    <reference evidence="1 2" key="5">
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            <dbReference type="PubMed" id="1851860"/>
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                <person name="Griffin B.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1 2" key="7">
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            <dbReference type="PubMed" id="1654446"/>
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            <dbReference type="DOI" id="10.1038/351078a0"/>
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            <dbReference type="PubMed" id="1333836"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
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            <dbReference type="PubMed" id="1321206"/>
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        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="1564" last="1570">
            <title>Identification and characterization of a human herpesvirus 6 gene segment that trans activates the human immunodeficiency virus type 1 promoter.</title>
            <authorList>
                <person name="Geng Y."/>
                <person name="Chandran B."/>
                <person name="Josephs S.F."/>
                <person name="Wood C."/>
            </authorList>
            <dbReference type="PubMed" id="1310766"/>
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            <strain evidence="1">U1102</strain>
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    <reference evidence="1 2" key="13">
        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="3918" last="3924">
            <title>Gene for the major antigenic structural protein (p100) of human herpesvirus 6.</title>
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                <person name="Neipel F."/>
                <person name="Ellinger K."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="1374813"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
            <strain evidence="2">Uganda-1102</strain>
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    </reference>
    <reference evidence="1 2" key="14">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="495" last="500">
            <title>The glycoprotein B homologue of human herpesvirus 6.</title>
            <authorList>
                <person name="Ellinger K."/>
                <person name="Neipel F."/>
                <person name="Foa-Tomasi L."/>
                <person name="Campadelli-Fiume G."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="8383182"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
            <strain evidence="2">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="15">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="613" last="622">
            <title>Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carrigan D.R."/>
                <person name="Carss A.L."/>
                <person name="Arno J."/>
            </authorList>
            <dbReference type="PubMed" id="8385692"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
            <strain evidence="2">Uganda-1102</strain>
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    <reference evidence="1 2" key="16">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="1847" last="1857">
            <title>Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein.</title>
            <authorList>
                <person name="Liu D.X."/>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lelliott C."/>
            </authorList>
            <dbReference type="PubMed" id="8397282"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
            <strain evidence="2">Uganda-1102</strain>
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    </reference>
    <reference evidence="1 2" key="17">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="4611" last="4620">
            <title>Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies.</title>
            <authorList>
                <person name="Pfeiffer B."/>
                <person name="Berneman Z.N."/>
                <person name="Neipel F."/>
                <person name="Chang C.K."/>
                <person name="Tirwatnapong S."/>
                <person name="Chandran B."/>
            </authorList>
            <dbReference type="PubMed" id="7687301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
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    <reference evidence="1 2" key="18">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="7680" last="7683">
            <title>Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29.</title>
            <authorList>
                <person name="Dewhurst S."/>
                <person name="Dollard S.C."/>
                <person name="Pellett P.E."/>
                <person name="Dambaugh T.R."/>
            </authorList>
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        </citation>
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    <reference evidence="1" key="19">
        <citation type="journal article" date="1993" name="J. Virol." volume="194" first="380" last="386">
            <title>Identification and characterization of glycoprotein gH of human herpesvirus-6.</title>
            <authorList>
                <person name="Qian G."/>
                <person name="Wood C."/>
                <person name="Chandran B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">U1102</strain>
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    </reference>
    <reference evidence="1 2" key="20">
        <citation type="journal article" date="1993" name="Virology" volume="195" first="521" last="531">
            <title>A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope.</title>
            <authorList>
                <person name="Pellett P.E."/>
                <person name="Sanchez-Martinez D."/>
                <person name="Dominguez G."/>
                <person name="Black J.B."/>
                <person name="Anton E."/>
                <person name="Greenamoyer C."/>
                <person name="Dambaugh T.R."/>
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            <dbReference type="DOI" id="10.1006/viro.1993.1403"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">U1102</strain>
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    </reference>
    <reference evidence="1 2" key="21">
        <citation type="journal article" date="1993" name="Virology" volume="197" first="12" last="22">
            <title>Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the target for neutralizing monoclonal antibodies.</title>
            <authorList>
                <person name="Liu D.X."/>
                <person name="Gompels U.A."/>
                <person name="Foa-Tomasi L."/>
                <person name="Campadelli-Fiume G."/>
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            <dbReference type="DOI" id="10.1006/viro.1993.1562"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="1 2" key="22">
        <citation type="journal article" date="1993" name="Virology" volume="197" first="449" last="454">
            <title>Identification and analysis of the transport/capsid assembly protein (tp/cap) gene of human herpesvirus-6 (HHV6).</title>
            <authorList>
                <person name="Jones M."/>
                <person name="Teo I."/>
            </authorList>
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            <dbReference type="DOI" id="10.1006/viro.1993.1610"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">U1102</strain>
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    </reference>
    <reference evidence="1 2" key="23">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
            <strain evidence="2">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="24">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="2978" last="2985">
            <title>Structure and transcription of an immediate-early region in the human herpesvirus 6 genome.</title>
            <authorList>
                <person name="Schiewe U."/>
                <person name="Neipel F."/>
                <person name="Schreiner D."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="8151768"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
            <strain evidence="2">Uganda-1102</strain>
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    </reference>
    <reference evidence="1 2" key="25">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="3007" last="3014">
            <title>Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Dewhurst S."/>
                <person name="Gray D."/>
            </authorList>
            <dbReference type="PubMed" id="8151770"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">U1102</strain>
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    <reference evidence="1 2" key="26">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="4126" last="4136">
            <title>Alphaherpesvirus origin-binding protein homolog encoded by human herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that are similar to ori regions of alphaherpesviruses.</title>
            <authorList>
                <person name="Inoue N."/>
                <person name="Dambaugh T.R."/>
                <person name="Rapp J.C."/>
                <person name="Pellett P.E."/>
            </authorList>
            <dbReference type="PubMed" id="8207791"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">U1102</strain>
            <strain evidence="2">Uganda-1102</strain>
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    <reference evidence="1 2" key="27">
        <citation type="journal article" date="1994" name="Oncogene" volume="9" first="1167" last="1175">
            <title>A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1.</title>
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                <person name="Thompson J."/>
                <person name="Choudhury S."/>
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                <person name="Berneman Z."/>
                <person name="Frenkel N."/>
                <person name="Rosenthal L.J."/>
            </authorList>
            <dbReference type="PubMed" id="8134119"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
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    <reference evidence="1 2" key="28">
        <citation type="journal article" date="1994" name="Virology" volume="199" first="311" last="322">
            <title>trans-activation of the HIV promoter by a cDNA and its genomic clones of human herpesvirus-6.</title>
            <authorList>
                <person name="Zhou Y."/>
                <person name="Chang C.K."/>
                <person name="Qian G."/>
                <person name="Chandran B."/>
                <person name="Wood C."/>
            </authorList>
            <dbReference type="PubMed" id="8122364"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1129"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">U1102</strain>
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    <reference evidence="1 2" key="29">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="304" last="311">
            <title>Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expression.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Weindler F.W."/>
                <person name="Gray D."/>
                <person name="Schwaab V."/>
                <person name="Helbronn R."/>
            </authorList>
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            <dbReference type="DOI" id="10.1006/viro.1994.1535"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">U1102</strain>
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    <reference evidence="1 2" key="30">
        <citation type="journal article" date="1995" name="J. Gen. Virol." volume="76" first="451" last="458">
            <title>Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Macaulay H.A."/>
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            <dbReference type="PubMed" id="7844567"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">U1102</strain>
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    <reference evidence="1 2" key="31">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
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            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
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    <reference evidence="1" key="32">
        <citation type="journal article" date="2017" name="Viruses" volume="10" first="E16" last="E16">
            <title>Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes.</title>
            <authorList>
                <person name="Tweedy J.G."/>
                <person name="Escriva E."/>
                <person name="Topf M."/>
                <person name="Gompels U.A."/>
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            <dbReference type="DOI" id="10.3390/v10010016"/>
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        <citation type="journal article" date="1989" name="J. Gen. Virol." volume="70" first="1151" last="1160">
            <title>Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Lawrence G.L."/>
                <person name="Barrell B.G."/>
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        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
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                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
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        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="714" last="722">
            <title>Identification, cloning, and expression of the major capsid protein gene of human herpesvirus 6.</title>
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                <person name="Littler E."/>
                <person name="Lawrence G."/>
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                <person name="Barrell B.G."/>
                <person name="Arrand J.R."/>
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        <citation type="journal article" date="1991" name="J. Gen. Virol." volume="72" first="157" last="168">
            <title>The genome of human herpesvirus 6: Maps of unit-length and concatemeric genomes for nine restriction endonucleases.</title>
            <authorList>
                <person name="Martin M."/>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
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                <person name="Arrand J.R."/>
                <person name="Teo I."/>
                <person name="Jones M.D."/>
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        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="2884" last="2894">
            <title>Identification, characterization, and sequence analysis of a cDNA encoding a phosphoprotein of human herpesvirus 6.</title>
            <authorList>
                <person name="Chang C.K."/>
                <person name="Balachandran N."/>
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        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="4670" last="4680">
            <title>Characterization of the DNA polymerase gene of human herpesvirus 6.</title>
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                <person name="Teo I.A."/>
                <person name="Griffin B.E."/>
                <person name="Jones M.D."/>
            </authorList>
            <dbReference type="PubMed" id="1651403"/>
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    </reference>
    <reference evidence="2 3" key="7">
        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="5381" last="5390">
            <title>Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6.</title>
            <authorList>
                <person name="Martin M.E.D."/>
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                <person name="Newman C."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1654446"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="8">
        <citation type="journal article" date="1991" name="Nature" volume="351" first="78" last="80">
            <title>Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Efstathiou S."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1851252"/>
            <dbReference type="DOI" id="10.1038/351078a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="9">
        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carss A.L."/>
                <person name="Sun N."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1333836"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="10">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1649" last="1660">
            <title>The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1321205"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="11">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="12">
        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="1564" last="1570">
            <title>Identification and characterization of a human herpesvirus 6 gene segment that trans activates the human immunodeficiency virus type 1 promoter.</title>
            <authorList>
                <person name="Geng Y."/>
                <person name="Chandran B."/>
                <person name="Josephs S.F."/>
                <person name="Wood C."/>
            </authorList>
            <dbReference type="PubMed" id="1310766"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="13">
        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="3918" last="3924">
            <title>Gene for the major antigenic structural protein (p100) of human herpesvirus 6.</title>
            <authorList>
                <person name="Neipel F."/>
                <person name="Ellinger K."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="1374813"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="14">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="495" last="500">
            <title>The glycoprotein B homologue of human herpesvirus 6.</title>
            <authorList>
                <person name="Ellinger K."/>
                <person name="Neipel F."/>
                <person name="Foa-Tomasi L."/>
                <person name="Campadelli-Fiume G."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="8383182"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="15">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="613" last="622">
            <title>Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carrigan D.R."/>
                <person name="Carss A.L."/>
                <person name="Arno J."/>
            </authorList>
            <dbReference type="PubMed" id="8385692"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="16">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="1847" last="1857">
            <title>Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein.</title>
            <authorList>
                <person name="Liu D.X."/>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lelliott C."/>
            </authorList>
            <dbReference type="PubMed" id="8397282"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="17">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="4611" last="4620">
            <title>Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies.</title>
            <authorList>
                <person name="Pfeiffer B."/>
                <person name="Berneman Z.N."/>
                <person name="Neipel F."/>
                <person name="Chang C.K."/>
                <person name="Tirwatnapong S."/>
                <person name="Chandran B."/>
            </authorList>
            <dbReference type="PubMed" id="7687301"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="18">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="7680" last="7683">
            <title>Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29.</title>
            <authorList>
                <person name="Dewhurst S."/>
                <person name="Dollard S.C."/>
                <person name="Pellett P.E."/>
                <person name="Dambaugh T.R."/>
            </authorList>
            <dbReference type="PubMed" id="8230490"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="19">
        <citation type="journal article" date="1993" name="Virology" volume="195" first="521" last="531">
            <title>A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope.</title>
            <authorList>
                <person name="Pellett P.E."/>
                <person name="Sanchez-Martinez D."/>
                <person name="Dominguez G."/>
                <person name="Black J.B."/>
                <person name="Anton E."/>
                <person name="Greenamoyer C."/>
                <person name="Dambaugh T.R."/>
            </authorList>
            <dbReference type="PubMed" id="7687803"/>
            <dbReference type="DOI" id="10.1006/viro.1993.1403"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="20">
        <citation type="journal article" date="1993" name="Virology" volume="197" first="12" last="22">
            <title>Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the target for neutralizing monoclonal antibodies.</title>
            <authorList>
                <person name="Liu D.X."/>
                <person name="Gompels U.A."/>
                <person name="Foa-Tomasi L."/>
                <person name="Campadelli-Fiume G."/>
            </authorList>
            <dbReference type="PubMed" id="7692666"/>
            <dbReference type="DOI" id="10.1006/viro.1993.1562"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="21">
        <citation type="journal article" date="1993" name="Virology" volume="197" first="449" last="454">
            <title>Identification and analysis of the transport/capsid assembly protein (tp/cap) gene of human herpesvirus-6 (HHV6).</title>
            <authorList>
                <person name="Jones M."/>
                <person name="Teo I."/>
            </authorList>
            <dbReference type="PubMed" id="8212582"/>
            <dbReference type="DOI" id="10.1006/viro.1993.1610"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="22">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="23">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="2978" last="2985">
            <title>Structure and transcription of an immediate-early region in the human herpesvirus 6 genome.</title>
            <authorList>
                <person name="Schiewe U."/>
                <person name="Neipel F."/>
                <person name="Schreiner D."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="8151768"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="24">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="3007" last="3014">
            <title>Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Dewhurst S."/>
                <person name="Gray D."/>
            </authorList>
            <dbReference type="PubMed" id="8151770"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="25">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="4126" last="4136">
            <title>Alphaherpesvirus origin-binding protein homolog encoded by human herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that are similar to ori regions of alphaherpesviruses.</title>
            <authorList>
                <person name="Inoue N."/>
                <person name="Dambaugh T.R."/>
                <person name="Rapp J.C."/>
                <person name="Pellett P.E."/>
            </authorList>
            <dbReference type="PubMed" id="8207791"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="26">
        <citation type="journal article" date="1994" name="Oncogene" volume="9" first="1167" last="1175">
            <title>A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1.</title>
            <authorList>
                <person name="Thompson J."/>
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                <person name="Doniger J."/>
                <person name="Berneman Z."/>
                <person name="Frenkel N."/>
                <person name="Rosenthal L.J."/>
            </authorList>
            <dbReference type="PubMed" id="8134119"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="27">
        <citation type="journal article" date="1994" name="Virology" volume="199" first="311" last="322">
            <title>trans-activation of the HIV promoter by a cDNA and its genomic clones of human herpesvirus-6.</title>
            <authorList>
                <person name="Zhou Y."/>
                <person name="Chang C.K."/>
                <person name="Qian G."/>
                <person name="Chandran B."/>
                <person name="Wood C."/>
            </authorList>
            <dbReference type="PubMed" id="8122364"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1129"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="28">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="304" last="311">
            <title>Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expression.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Weindler F.W."/>
                <person name="Gray D."/>
                <person name="Schwaab V."/>
                <person name="Helbronn R."/>
            </authorList>
            <dbReference type="PubMed" id="8091661"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1535"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="29">
        <citation type="journal article" date="1995" name="J. Gen. Virol." volume="76" first="451" last="458">
            <title>Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7844567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="30">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Uganda-1102</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="SPC53497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="SPC53497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000009295"/>
        </source>
    </evidence>
    <sequence length="54" mass="5923" checksum="76A396FED7FF8483" modified="2018-04-25" version="1">MTSKCMLCWTAITNALAILMLLLVIYRAIIGFNGDIYTSTLSAFSCIRTNSSNT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-11-02" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>P0DOE0</accession>
    <name>GQ2_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Glycoprotein Q2</fullName>
            <shortName>gQ2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Glycoprotein Q-37k</fullName>
            <shortName>gQ-37k</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">U100</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1649" last="1660">
            <title>The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1321205"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="7969" last="7983">
            <title>Intracellular processing of human herpesvirus 6 glycoproteins Q1 and Q2 into tetrameric complexes expressed on the viral envelope.</title>
            <authorList>
                <person name="Akkapaiboon P."/>
                <person name="Mori Y."/>
                <person name="Sadaoka T."/>
                <person name="Yonemoto S."/>
                <person name="Yamanishi K."/>
            </authorList>
            <dbReference type="PubMed" id="15254169"/>
            <dbReference type="DOI" id="10.1128/JVI.78.15.7969-7983.2004"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>GS</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2014" name="Microbiol. Immunol." volume="58" first="22" last="30">
            <title>Human herpesvirus-6A gQ1 and gQ2 are critical for human CD46 usage.</title>
            <authorList>
                <person name="Jasirwan C."/>
                <person name="Furusawa Y."/>
                <person name="Tang H."/>
                <person name="Maeki T."/>
                <person name="Mori Y."/>
            </authorList>
            <dbReference type="PubMed" id="24215487"/>
            <dbReference type="DOI" id="10.1111/1348-0421.12110"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HOST CD46</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in virus entry by participating in host receptor binding at the cell surface.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Interacts with isoform gQ1. Associates with the glycoprotein complex gH-gL (PubMed:15254169). The gH/gL/gQ1/gQ2 complex binds to human receptor CD46 (PubMed:24215487).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Virion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host endoplasmic reticulum-Golgi intermediate compartment</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P0DOE0-1</id>
            <name evidence="5">Glycoprotein Q2</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q69572-1</id>
            <name evidence="5">Glycoprotein Q1</name>
            <sequence type="external"/>
        </isoform>
        <isoform>
            <id>P0DOE0-2</id>
            <name evidence="5">Glycoprotein Q0</name>
            <sequence type="not described"/>
        </isoform>
    </comment>
    <comment type="PTM">
        <text evidence="3">Glycosylated by host.</text>
    </comment>
    <comment type="miscellaneous">
        <molecule>Isoform Glycoprotein Q0</molecule>
        <text evidence="3">This chain is predicted but has not been detected in HHV-6A-infected cells and virion.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL" id="X83413"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0025">Alternative splicing</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-0426">Late protein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-1161">Viral attachment to host cell</keyword>
    <keyword id="KW-1234">Viral attachment to host entry receptor</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-1160">Virus entry into host cell</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000438170" description="Glycoprotein Q2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15254169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="24215487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="15254169"/>
        </source>
    </evidence>
    <sequence length="214" mass="25121" checksum="828293200812D1F6" modified="2016-11-02" version="1" precursor="true">MHFLVVYILIHFHAYRGMAALPLFSTLPKITSCCDSYVVINSSTSVSSLISTCLDGEILFQNEGQKFCRPLTDNRTIVYTMQDQVQKPLSVTWMDFNLVISDYGRDVINNLTKSAMLARKNGPRYLQMENGPRYLQMETRISDLFRHECYQDNYYVLDKKLQMFYPTTHSNELLFYPSEATLPSPWQEPPFSSPWPEPTFPSRWYWLLLNYTNY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-11-01" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>P17887</accession>
    <name>MCP_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major capsid protein</fullName>
            <shortName evidence="1">MCP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MCP</name>
        <name type="synonym">4L</name>
        <name type="synonym">U57</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="714" last="722">
            <title>Identification, cloning, and expression of the major capsid protein gene of human herpesvirus 6.</title>
            <authorList>
                <person name="Littler E."/>
                <person name="Lawrence G."/>
                <person name="Liu M.Y."/>
                <person name="Barrell B.G."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="2153237"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae major capsid protein family.</text>
    </comment>
    <dbReference type="EMBL" id="M33515">
        <property type="protein sequence ID" value="AAA51531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E33560">
        <property type="entry name" value="VCBEH6"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042950.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P17887"/>
    <dbReference type="PRIDE" id="P17887"/>
    <dbReference type="GeneID" id="1487939"/>
    <dbReference type="KEGG" id="vg:1487939"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04016">
        <property type="entry name" value="HSV_MCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000912">
        <property type="entry name" value="Herpes_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023233">
        <property type="entry name" value="Herpes_MCP_upper_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03122">
        <property type="entry name" value="Herpes_MCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00235">
        <property type="entry name" value="HSVCAPSIDMCP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103417">
        <property type="entry name" value="SSF103417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0167">Capsid protein</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1147">T=16 icosahedral capsid protein</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000115705" description="Major capsid protein">
        <location>
            <begin position="1"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1 and 2." evidence="2" ref="1 2">
        <original>E</original>
        <variation>K</variation>
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1 and 2." evidence="2" ref="1 2">
        <original>K</original>
        <variation>E</variation>
        <location>
            <position position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1345" mass="151951" checksum="F1DE8D083A85A949" modified="1996-10-01" version="3">MENWQATEILPKIEAPLNIFNDIKTYTAEQLFDNLRIYFGDDPSRYNISFEALLGIYCNKIEWINFFTTPIAVAANVIRFNDVSRMTLGKVLFFIQLPRVATGNDVTASKETTIMVAKHSEKHPINISFDLSAACLEHLENTFKNTVIDQILNINALHTVLRSLKNSADSLERGLIHAFMQTLLRKSPPQFIVLTMNENKVHNKQALSRVQRSNMFQSLKNRLLTSLFFLNRNNNISYIYRILNDMMESVTESILNDTNNYTSKENVPLDGVLLGPIGSIQKLTSILSQYISTQVVSAPISYGHFIMGKENAVTAIAYRAIMADFTQFTVNAGTEQQDTNNKSEIFDKSRAYADLKLNTLKLGDKLVAFDHLHKVYKNTDVNDPLEQSLQLTFFFPLGIYIPSETGFSTMETRVKLNDTMENNLPTSVFFHNKDQVVQRIDFADILPSVCHPIVHDSTIVERLMKSEPLPTGHRFSQLCQLKITRENPARILQTLYNLYESRQEVPKNTNVLKNELNIEDFYKPDNPTLPTERHPFFDLTYIQKNRATEVLCTPRIMIGNIPLPLAPVSFHEARTNQILEHAKTNCQKYDFTLKIVTESLTSGSYPELAYVIETLVHGNKHAFMILKQVISQCISYWFNMKHILLFCNSFEMIMLISNHMGDELIPGAAFAHYRNLVSLIRLVKRTISISNLNEQLCGEPLVNFANALFDGRLFCPFVHTMPRNDTNAKITADDTPLTQNTVRVRNYEISDVQRMNLIDSSVVFTDNDRPSNETTILSKIFYFCVLPALSNNKACGAGVNVKELVLDLFYTEPFISPDDYFQENPITSDVLMSLIREGMGPGYTVANTSCIAKQLFKSLIYINENTKILEVEVSLDPAQRHGNSVHFQSLQHILYNGLCLISPITTLRRYYQPIPFHRFFSDPGICGTMNADIQVFLNTFPHCQRNDGGFPLPPPLALEFYNWQRTPFSVYSAFCPNSLLSIMTLAAMHSKLSPVAIAIQSKNKIHPGFAATLVRTDNFDVECLLYSSRAATSIILDDPTVTAEAKDIATTYNFTQHLSFVDMGLGFSSTTATANLKRIKSDMGSKIQNLFSAFPIHAFTNADINTWIRHHVGIEKPNPSESEALNIITFGGINKNPPSILLHGQQAICEVILTPVTTNINFFKSPHNPRGRESCMMGTDPHNEEAARKALYDHTQTDSDTFAATTNPWASLPGSLGDILYNTAHREQLCYNPKTYSPNAQFFTESDILKTNKMMYKVISEYCMKSNSCLNSDSEIQYSCSEGTDSFVSRPCQFLQNALPLHCSSNQALLESRSKTGNTQISETHYCNYAIGETIPFQLIIESSI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>P24433</accession>
    <name>SCAF_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Capsid scaffolding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Capsid protein P40</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protease precursor</fullName>
            <shortName evidence="2">pPR</shortName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="2">Assemblin</fullName>
                <ecNumber evidence="2">3.4.21.97</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">Protease</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="2">Assembly protein</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">Capsid assembly protein</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name type="primary">U53</name>
        <name type="synonym">0R</name>
        <name type="synonym">XKRF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 410-528</scope>
    </reference>
    <comment type="function">
        <molecule>Capsid scaffolding protein</molecule>
        <text evidence="2">Acts as a scaffold protein by binding major capsid protein in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein. Cleavages products are evicted from the capsid before or during DNA packaging.</text>
    </comment>
    <comment type="function">
        <molecule>Assemblin</molecule>
        <text evidence="2">Protease that plays an essential role in virion assembly within the nucleus. Catalyzes the cleavage of the assembly protein after formation of the spherical procapsid. By that cleavage, the capsid matures and gains its icosahedral shape. The cleavage sites seem to include -Ala-Ser-, -Ala-Ala-, as well as Ala-Thr bonds. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging.</text>
    </comment>
    <comment type="function">
        <molecule>Assembly protein</molecule>
        <text evidence="2">Plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein. Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Cleaves -Ala-|-Ser- and -Ala-|-Ala- bonds in the scaffold protein.</text>
            <dbReference type="EC" id="3.4.21.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Capsid scaffolding protein homomultimerizes and interacts with major capsid protein. Assemblin exists in a monomer-dimer equilibrium with the dimer being the active species. Assembly protein homomultimerizes and interacts with major capsid protein.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Capsid scaffolding protein</molecule>
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Assemblin</molecule>
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="subcellular location">
        <molecule>Assembly protein</molecule>
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <isoform>
            <id>P24433-1</id>
            <name>Capsid scaffolding protein</name>
            <name>pPR</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P24433-2</id>
            <name>pAP</name>
            <name>Assembly protein</name>
            <sequence type="described" ref="VSP_037418"/>
        </isoform>
    </comment>
    <comment type="domain">
        <text evidence="2">Region of interaction between pPR and pAP is called Amino conserved domain (ACD). The region of interaction with major capsid protein is called carboxyl conserved domain (CCD).</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Capsid scaffolding protein is cleaved by assemblin after formation of the spherical procapsid. As a result, the capsid obtains its mature, icosahedral shape. Cleavages occur at two or more sites: release and tail site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae capsid scaffolding protein family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.97" evidence="2"/>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042946.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P24433"/>
    <dbReference type="BindingDB" id="P24433"/>
    <dbReference type="ChEMBL" id="CHEMBL4010"/>
    <dbReference type="MEROPS" id="S21.004"/>
    <dbReference type="PRIDE" id="P24433"/>
    <dbReference type="DNASU" id="1487933"/>
    <dbReference type="GeneID" id="1487933"/>
    <dbReference type="KEGG" id="vg:1487933"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039708">
        <property type="term" value="P:nuclear capsid assembly"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.16.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04008">
        <property type="entry name" value="HSV_SCAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035443">
        <property type="entry name" value="Herpes_virus_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001847">
        <property type="entry name" value="Peptidase_S21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00716">
        <property type="entry name" value="Peptidase_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00236">
        <property type="entry name" value="HSVCAPSIDP40"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0877">Alternative promoter usage</keyword>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0118">Viral capsid assembly</keyword>
    <keyword id="KW-1188">Viral release from host cell</keyword>
    <feature type="chain" id="PRO_0000376801" description="Capsid scaffolding protein">
        <location>
            <begin position="1"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000027265" description="Assemblin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000027266" description="Assembly protein" evidence="2">
        <location>
            <begin position="231"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with pAP" evidence="2">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with major capsid protein" evidence="2">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="1">
        <location>
            <begin position="416"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by assemblin; Release site" evidence="2">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by assemblin; Tail site" evidence="1">
        <location>
            <begin position="491"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="splice variant" id="VSP_037418" description="In isoform pAP." evidence="4">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="528" mass="58636" checksum="3C043B8224D285CB" modified="1996-10-01" version="2">MSKVWVGGFLCVYGEEPSEECLALPRDTVQKELGSGNIPLPLNINHNEKATIGMVRGLFDLEHGLFCVAQIQSQTFMDIIRNIAGKSKLITAGSVIEPLPPDPEIECLSSSFPGLSLSSKVLQDENLDGKPFFHHVSVCGVGRRPGTIAIFGREISWILDRFSCISESEKRQVLEGVNVYSQGFDENLFSADLYDLLADSLDTSYIRKRFPKLQLDKQLCGLSKCTYIKASEPPVEIIVAATKVAGDQVQLTTEPGSELAVETCDVPVVHGNYDAVESATATTAMSNQNLPNTTPLLSSPPFSDCVFLPKDAFFSLLNVTTGQQPKIVPPVSVHPPVTEQYQMLPYSESAAKIAEHESNRYHSPCQAMYPYWQYSPVPQYPAALHGYRQSKTLKKRHFQSDSEDELSFPGDPEYTKKRRRHRVDNDDDKEMAREKNDLRELVDMIGMLRQEISALKHVRAQSPQRHIVPMETLPTIEEKGAASPKPSILNASLAPETVNRSLAGQNESTDLLKLNKKLFVDALNKMDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>P24434</accession>
    <name>VU54_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U54</name>
        <name type="synonym">1L</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae UL82 family.</text>
    </comment>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B33560">
        <property type="entry name" value="B33560"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042947.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24434"/>
    <dbReference type="DNASU" id="1487936"/>
    <dbReference type="GeneID" id="1487936"/>
    <dbReference type="KEGG" id="vg:1487936"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008649">
        <property type="entry name" value="Herpes_UL82/UL83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05784">
        <property type="entry name" value="Herpes_UL82_83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116288" description="Protein U54">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="458" mass="51498" checksum="444CAFD6B41374E8" modified="1992-03-01" version="1">MQPATLQWSSYVLQLRVTTTAILKPGELRLFKCGLGITPPSSAVVCICRDESSFTSSPFTYIDPKDYGNIPFAVQNISDLDLDLSRLPIVLNIFALPHANVNISNLPVQRIEAHDRHIIPHGQCDAKFVIYGPLTRIKIQVADIRWIEQTPEEPTRYSFKAEIWVNLQNTPLDQIFKTGNIEFISHKNVYISRILLCGNLLILKANYENDYLLDDNFYPEQLAIQISLTPQTADITLSQNQETLLKCNTHSITVCATKNIIPNTVTPVHCSFNTIFNSNSNFTGLFIPKLLLGISTTTGIWDETRPLYITMKAFKKNRRINYSQPIGVVYFFPKQILPPGNNVEFNWTEASKIYVNTESPNGPVRNTVTFTNQAVLRTPSLSTVANLTPDINMGIFLSSLRVAFDTAHMVPLHFSLKPGESTRMEFMPPGTPQNLTILEGDVGIHFIPCHNHSHRSSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>P24435</accession>
    <name>VU55_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U55</name>
        <name type="synonym">2L</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C33560">
        <property type="entry name" value="C33560"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042948.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24435"/>
    <dbReference type="DNASU" id="1487937"/>
    <dbReference type="GeneID" id="1487937"/>
    <dbReference type="KEGG" id="vg:1487937"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009479">
        <property type="entry name" value="Herpes_U55"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06501">
        <property type="entry name" value="Herpes_U55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116294" description="Uncharacterized protein U55">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <sequence length="432" mass="50171" checksum="85F04144F1FC9D8B" modified="1992-03-01" version="1">MFSPQLNHVLQLVFDCNHIVSNSYQEIILKCRISSTKPGILFITDGTESETEDVLFDVQFLEKTTTIKIKILPISRTVPVRIHLFSIPIYLPSHALEIDDINALCQKENIDPTVYEQYGLTNMPISTTNVINQFKVVQNDSVEMSLILFNLNWTESPYQSQKLDRYGRKLLIVFSVFSIDTRECPYWENLFKSIIPLCRVNMISEPGISIYKIEFNDPFLTVFLRNVVLPENKRRFPITKECYLRLTFSPPDRSTVTLNMNMPYFKICADGKNLEVFFPNDMSLVSNTNKEITLRGEFTNKKIVGIFIPVQTHVFKLYPFLWFAQEPLKLRISCERTVSVTEHDMLGRVFFVTKKLFRKPFRSLSNSDMKSLLTHTENTDKPFDVHFMGNCFPAYLLPELTLHPLEYEDKPARGNPQTLPSVEKHSIIKIRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2021-06-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>P24436</accession>
    <name>TRX2_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triplex capsid protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRX2</name>
        <name type="ordered locus">U56</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with TRX1 and major capisd protein/MCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae TRX2 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D33560">
        <property type="entry name" value="D33560"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042949.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P24436"/>
    <dbReference type="PRIDE" id="P24436"/>
    <dbReference type="DNASU" id="1487938"/>
    <dbReference type="GeneID" id="1487938"/>
    <dbReference type="KEGG" id="vg:1487938"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04019">
        <property type="entry name" value="HSV_TRX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002690">
        <property type="entry name" value="Herpes_capsid_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01802">
        <property type="entry name" value="Herpes_V23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0167">Capsid protein</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000115727" description="Triplex capsid protein 2">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04019"/>
        </source>
    </evidence>
    <sequence length="296" mass="33464" checksum="2637449E819F36CE" modified="1992-03-01" version="1">METVYCTFDHKLSLSDISTLCKLMNIVIPIPAHHHLIGSGNLGLYPIVSSNKDYVHVRNVLRTMVVTILQKVEGNQLVLRKPVTGHQYAIKNTGPFPWEKGDTLTLIPPLSTHSEEKLLKLGDWELTVPLVVPTAIAAEINIRLLCIGLIAVHREYNEMQTIIDELCSIQYRDVLIKLPDIVNDKQSMYSMKTACISLSMITAMAPDIVRTYIDRLTLEDHSMLLIKCQELLSKRTTLNTQRCGQLHATEIKDELKKVKSVLTMIDQINSLTNEKTYFVVCDVSADNRMATCIYKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>P24438</accession>
    <name>UL88_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U59</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U59</name>
        <name type="synonym">6R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae U59/UL88 family.</text>
    </comment>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G33560">
        <property type="entry name" value="G33560"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042952.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24438"/>
    <dbReference type="DNASU" id="1487941"/>
    <dbReference type="GeneID" id="1487941"/>
    <dbReference type="KEGG" id="vg:1487941"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007616">
        <property type="entry name" value="Herpes_U59/UL88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04529">
        <property type="entry name" value="Herpes_U59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116232" description="Protein U59">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="350" mass="39883" checksum="B00FCB1C561F287E" modified="1995-11-01" version="2">MNVLVADEWFDCAIRLDSETIAVHEIFNPELSKLLNLHSKTVYMSDLCAFISGCVNRNVGKLTIYWHVNGDIIYALTGILHCVKIKIECGERIADGRYRLYEIPKLFLMRGQSTPMELKWKHAVGIATTNKPLLTHVLTDVLETSPFTLPDTLLSVQELSIFRERLSYIYYVLGSDVDIVARTEREIFQKCAELARLQQVFLIQGNIMENFVLAQACLFQLGADGLWEEISGSVRPRPELMSSAFIQHRVMLNNCYCIAVIFNAIYKHKLSLPTVERSHETVNRVAQEYYKSYVNAPLSVLVCATKVLTLFTEEYNFKSALVFVSQFFQVDVEASRADVIRLFLACLKGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>P24439</accession>
    <name>UL91_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U62</name>
        <name type="synonym">8R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae UL91 family.</text>
    </comment>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H33560">
        <property type="entry name" value="H33560"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042955.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P24439"/>
    <dbReference type="PRIDE" id="P24439"/>
    <dbReference type="DNASU" id="1487943"/>
    <dbReference type="GeneID" id="1487943"/>
    <dbReference type="KEGG" id="vg:1487943"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035385">
        <property type="entry name" value="U62/UL91"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17442">
        <property type="entry name" value="U62_UL91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116235" description="Protein U62">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="85" mass="9579" checksum="EF2442C635603870" modified="1992-03-01" version="1">MNSALNGIKDDFENCETKDDLFKIIDKISKNCNFIVEQVESLPRRVDSAAILFDNLAVEIFNDVIYRQNGVAAKIRQGNGQDIDT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>P24440</accession>
    <name>UL92_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U63</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U63</name>
        <name type="synonym">9R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae UL92 family.</text>
    </comment>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="I33560">
        <property type="entry name" value="QQBEH8"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042956.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24440"/>
    <dbReference type="DNASU" id="1487944"/>
    <dbReference type="GeneID" id="1487944"/>
    <dbReference type="KEGG" id="vg:1487944"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004289">
        <property type="entry name" value="Herpes_UL92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03048">
        <property type="entry name" value="Herpes_UL92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116239" description="Protein U63">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="216" mass="24782" checksum="88255034075AAFE4" modified="1992-03-01" version="1">MELPRKYDRVTGRILTHKNNQMCTTECSQMYNLHNPITFELGLGNVFVCMRCLTVHHCDMQTDCTIVNTHEGYVCAKTGLFYSGWMPAYADCFLEPICEPNIETVNVVVVLLSYVYSFLMENKERYAAIIDSIIKDGKFIKNVEDAVFYTFNAVFTNSTFNKIPLTTISRLFVQLIIGGHAKGTIYDSNVIRVSRRKREDSLLKKMRLEYGNALIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>P24441</accession>
    <name>CVC1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Capsid vertex component 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CVC1</name>
        <name type="ordered locus">10R</name>
        <name type="ordered locus">U64</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via C-terminus) with capsid vertex component 2/CVC2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae CVC1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A36769">
        <property type="entry name" value="A36769"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042957.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24441"/>
    <dbReference type="DNASU" id="1487946"/>
    <dbReference type="GeneID" id="1487946"/>
    <dbReference type="KEGG" id="vg:1487946"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04017">
        <property type="entry name" value="HSV_CVC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007640">
        <property type="entry name" value="UL17-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04559">
        <property type="entry name" value="Herpes_UL17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0167">Capsid protein</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0426">Late protein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0231">Viral genome packaging</keyword>
    <keyword id="KW-1188">Viral release from host cell</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000115959" description="Capsid vertex component 1">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04017"/>
        </source>
    </evidence>
    <sequence length="442" mass="51391" checksum="9A5F3383DF05CDDB" modified="1992-03-01" version="1">METHLYYDTLYQYQGGVYPAHICLPTDVCLPMRVDCIESLYFRCVFFKSGMHYTEWSKLKFTVISREIKFKDVLKDADSDEVFTGLVVMTIPIPIVDFHFDIDSVILKLVYPRLVHREIVLRLYDLICVRPPSNRPSEASAKNIANDFYQLTSRENKQTPDEEKRCLFFQQGPLEPPSTVRGLKAPGNEKPIQFPAHANEKMTESFLSDSWFGQKVRCKKILDFTQTYQVVVCWYELSFSREMQIENNLLSASQLKRVNAADFWDRTNRYLRDIGSRVLTHIVKTLQIHNRQFKQKFNCNFPDNFSFDRLLSFMQLGKDFWILNLTLDSCIIKAIICFLGFQNGGKSFLAQDEVWGDLIDCSKGSVIYGEKIQWILDSTNNLYSTCREKQNKSWELYVDCCALYVSEKLELDFVLPGGFAITGKFALTDGDIDFFNWRFGLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-02-23" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>P24442</accession>
    <name>CEP2_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytoplasmic envelopment protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U65</name>
        <name type="synonym">11R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with cytoplasmic envelopment protein 3 and with the capsid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B36769">
        <property type="entry name" value="B36769"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042958.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24442"/>
    <dbReference type="DNASU" id="1487947"/>
    <dbReference type="GeneID" id="1487947"/>
    <dbReference type="KEGG" id="vg:1487947"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04039">
        <property type="entry name" value="HSV_CEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004286">
        <property type="entry name" value="Herpes_UL16/UL94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03044">
        <property type="entry name" value="Herpes_UL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0426">Late protein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-0920">Virion tegument</keyword>
    <feature type="chain" id="PRO_0000115950" description="Cytoplasmic envelopment protein 2">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04039"/>
        </source>
    </evidence>
    <sequence length="335" mass="37877" checksum="177BC8ED39DEE014" modified="1992-03-01" version="1">MAISTFSIGDLGYLRNFLQNECNWFRICKKTFYREYRSVATSSPTFSLNNKPKKFCMHCEIVIFKRSEEFMFSLAVNGIHFGQFLTGKMKFNKKAVPEGLYYYILELGSITPIDLGFIPRYNSDCVTNMRCVTPEVIYENCSIVCPEEANRLTVKGSGDNKLTPLGGCGAWCLKNGGDLYIYTFALAYDLFLTCYDKSTFPSLAKIIFDMIACESEDCVFCKDHNKHVSQAGQIVGCVSNQETCFCYTSCKKKMANINNPELISLLCDQEINKIDIMYPKIKASLSLDINSYAHGYFGDDPYALKCVNWIPVRISAALSRLIVLSCPVCKRVVMD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>P24443</accession>
    <name>TRM3_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tripartite terminase subunit 3</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Terminase large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRM3</name>
        <name type="ordered locus">12L/7L</name>
        <name type="ordered locus">U66/U60</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the terminase subunits TRM1 and TRM2. Interacts with portal protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Responsible for the nuclear localization of the two others subunits TRM1 and TRM2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae TRM3 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58358.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58352.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A33560">
        <property type="entry name" value="QQBEH6"/>
    </dbReference>
    <dbReference type="SMR" id="P24443"/>
    <dbReference type="PRIDE" id="P24443"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04013">
        <property type="entry name" value="HSV_TRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003498">
        <property type="entry name" value="DNA_pack_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038435">
        <property type="entry name" value="DNA_pack_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003499">
        <property type="entry name" value="DNA_pack_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033663">
        <property type="entry name" value="HSV_TRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02499">
        <property type="entry name" value="DNA_pack_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02500">
        <property type="entry name" value="DNA_pack_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0231">Viral genome packaging</keyword>
    <keyword id="KW-1188">Viral release from host cell</keyword>
    <feature type="chain" id="PRO_0000115941" description="Tripartite terminase subunit 3">
        <location>
            <begin position="1"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Walker A motif" evidence="1">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Walker B motif" evidence="1">
        <location>
            <begin position="301"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="For ATPase activity" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="1">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="1">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="1">
        <location>
            <position position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04013"/>
        </source>
    </evidence>
    <sequence length="667" mass="76360" checksum="00F35C12C4039784" modified="1995-11-01" version="2">MLRTCDITHIKNNYEAIIWKGERDCSTISTKYPNSAIFYKKRFIMLTPELGFAHSYNQQVKPLYTFCEKQRHLKNRKPLTILPSLSHKLQEMKFLPASDKSFESQYTEFLESFKILYREPLFLQIDGFIKDFRKWIKGEFNDFGDTRKIQLEPFQKNILIHVIFFIAVTKLPALANRVINYLTHVFDIEFVNESTLNTLKQKTNVFLVPRRHGKTWFIVPIISFLLKNIEGISIGYVAHQKHVSHFVMKEVEFKCRRMFPEKTITCLDNVITIDHQNIKSTALFASCYNTHQSIRGQSFNLLIVDESHFIKKDAFSTILGFLPQASTKILFISSTNSGNHSTSFLMKLNNSPFEMLSVVSYVCEDHAHMLNERGNATACSCYRLHKPKFISINAEVKKTANLFLEGAFIHEIMGGATCNVINDVLITEQGQTEFEFFRYSTINKNLIPFLGKDLYVYLDPAYTGNRRASGTGIAAIGTYLDQYIVYGMEHYFLESLMTSSDTAIAECAAHMILSILDLHPFFTEVKIIIEGNSNQASAVKIACIIKENITANKSIQVTFFHTPDQNQIAQPFYLLGKEKKLAVEFFISNFNSGNIKASQELISFTIKITYDPVEYALEQIRNIHQISVNNYITYSAKKQACSDDLIIAIIMAIYVCSGNSSASFREI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>P24444</accession>
    <name>UL95_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U67</name>
        <name type="synonym">13R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae UL95 family.</text>
    </comment>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C36769">
        <property type="entry name" value="C36769"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042960.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24444"/>
    <dbReference type="DNASU" id="1487948"/>
    <dbReference type="GeneID" id="1487948"/>
    <dbReference type="KEGG" id="vg:1487948"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004280">
        <property type="entry name" value="Herpes_UL95"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03038">
        <property type="entry name" value="Herpes_UL95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116244" description="Protein U67">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="353" mass="39532" checksum="E30E73D5D0ACEBA7" modified="1996-10-01" version="2">MWVMSQVRSMEPDLTLAAVYQAAANLTEQDKEIFAEAVKTAFSVCSSAAPSARLRMIETPTQNFMFVTSVIPSGVTSGEKKTKLNIDAALDNLALSFANKKSKKMARTYLLQNVLRTQDQQVAISGKYILYTKKHIETSLMIDKTKLVKKILEYAETPNLLGYTDVRDLECLLWLVFCGPKSFCQSDSCFGYSKTGYNAAFPNLLPPYLYECGQNNGLFFGIVQAYVFSWYSDFDFSALEISERARRRIRSLLYDLKQKFAEQEVSVLSVASQMCIFCALYKQNKLSLEYVSGDLKTSVFSPIIIKDCLCAQTTISTTQMLPGTKSSAIFPVYDLRKLLGALVISEGSVKFDI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-02-23" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>P24445</accession>
    <name>UL96_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U68</name>
        <name type="synonym">14R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae UL96 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D36769">
        <property type="entry name" value="D36769"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042961.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P24445"/>
    <dbReference type="PRIDE" id="P24445"/>
    <dbReference type="DNASU" id="1487949"/>
    <dbReference type="GeneID" id="1487949"/>
    <dbReference type="KEGG" id="vg:1487949"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022614">
        <property type="entry name" value="Herpesvirus_UL96"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10867">
        <property type="entry name" value="DUF2664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116249" description="Protein U68">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="114" mass="13074" checksum="DABCC7AF04485E3B" modified="1992-03-01" version="1">MSLKDYLRQSISKDLEVRHRDSLKIRLGERHPLSVHQHMIAARQIIKSDNAEQQHVISSLSGFLDKQKSFLRVQQKALKQLEKLDVDEIIDTAAEVKAVSNDIKETLITSTELE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>P24446</accession>
    <name>GCVK_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Probable ganciclovir kinase</fullName>
            <ecNumber>2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U69</name>
        <name type="synonym">15R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates the antiviral nucleoside analog ganciclovir.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. Tyr protein kinase family. HCMV ganciclovir subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-"/>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E36769">
        <property type="entry name" value="QQBEH5"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042962.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24446"/>
    <dbReference type="DNASU" id="1487950"/>
    <dbReference type="GeneID" id="1487950"/>
    <dbReference type="KEGG" id="vg:1487950"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010615">
        <property type="entry name" value="Herpes_UL97"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06734">
        <property type="entry name" value="UL97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0244">Early protein</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000088194" description="Probable ganciclovir kinase">
        <location>
            <begin position="1"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="201"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="562" mass="63717" checksum="09111202754CC071" modified="1992-03-01" version="1">MDNGVETPQGQKTQPINLPPVRKKLRKHEGLGKGVKRKLFAEDSSPLKKQISACSDMETLSSPVKSECESRSASLDESFGKCKHEIACDCSAIEELLCHESLLDSPMKLSNAHTIFSSNKWKLELEKIIASKQIFLDMSENAELAAYGETLCNLRIFEKISSPFLFDVQSEERSYSVVYVPHNKELCGQFCQPEKTMARVLGVGAYGKVFDLDKVAIKTANEDESVISAFIAGVIRAKSGADLLSHECVINNLLISNSVCMSHKVSLSRTYDIDLHKFEDWDVRNVMNYYSVFCKLADAVRFLNLKCRINHFDISPMNIFLNHKKEIIFDAVLADYSLSEMHPNYNGTCAIAKEYDKNLQLVPISRNKFCDMFNPGFRPLVANAMILVNVCGAFDGENNPLRHCNLDLCAFAQVVLSCVLRMTDKRGCREAQLYYEKRLFALANEACRLNPLKYPFAYRDACCKVLAEHVVLLGLLFYRDVVEIYEKLYDFLDERGEFGSRDLFEATFLNNSKLTRRQPIREGLASLQSSEYGEKLLHDLRELFLINSTADLDKDTSSLFHM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-02-23" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>P24447</accession>
    <name>AN_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alkaline nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U70</name>
        <name type="synonym">16R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-&gt; 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with major DNA-binding protein; this interaction increases the nuclease processivity of the alkaline exonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae alkaline nuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F36769">
        <property type="entry name" value="QQBEHS"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042963.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P24447"/>
    <dbReference type="PRIDE" id="P24447"/>
    <dbReference type="GeneID" id="1487951"/>
    <dbReference type="KEGG" id="vg:1487951"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04009">
        <property type="entry name" value="HSV_AN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001616">
        <property type="entry name" value="Herpes_alk_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00924">
        <property type="entry name" value="ALKEXNUCLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000115694" description="Alkaline nuclease">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="site" description="Required for function" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="site" description="Required for function" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="site" description="Required for function" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="site" description="Required for function" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04009"/>
        </source>
    </evidence>
    <sequence length="488" mass="56645" checksum="0F38A10597366A5B" modified="1992-03-01" version="1">MDLDQISETLSSVAEEEPLTMFLLDKLYAIREKIKQVPFSIVRLCHVYCMLIKYNASNNNCILGRKLIEEMQQFLCGTRVDGSEDISMDLSELCKLYDYCPLLCSALCRAPCVSVNKLFKIVERETRGQSENPLWHALRKYTVTATKLYDIYTTRCFLEYKGQQFFGEAVIYGAKHERVIRHLVATFYVKREVKETLGLLLDPSSGVFGASLDACFGISFNEDGFLMVKEKALIFEIKFKYKYLRDKEDHFVSELLKNPTEKSFSDFILSHPVPVIEFRERGKIPSSREYLMTYDFQYRPQRKLRTCPTPAILAPHIKQLLCLNETQKSTVIVFDCKSDLCEQKLSVFQKAVFTVNVFVNPKHRYFFQSLLQQYVMTQFYINDHNNPEYIESTEVPSVHIVTAFFRRRTEEERSLHLVIDETEYIEEEIPLALIVTPVAPNPEFTCCVITDICNLWENNICKQTSLQVWAQSAVNQYLAACVRKPKTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-02-23" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>P24448</accession>
    <name>CEP3_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytoplasmic envelopment protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U71</name>
        <name type="synonym">17R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Virion membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G36769">
        <property type="entry name" value="G36769"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042964.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="IntAct" id="P24448">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24448"/>
    <dbReference type="DNASU" id="1487952"/>
    <dbReference type="GeneID" id="1487952"/>
    <dbReference type="KEGG" id="vg:1487952"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04041">
        <property type="entry name" value="HSV_CEP3_betahv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020170">
        <property type="entry name" value="Herpes_UL11_megaloV/roseoloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034705">
        <property type="entry name" value="HSV_CEP3_betahv"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17474">
        <property type="entry name" value="U71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1032">Host cell membrane</keyword>
    <keyword id="KW-1040">Host Golgi apparatus</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0519">Myristate</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-0920">Virion tegument</keyword>
    <feature type="initiator methionine" description="Removed; by host" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000115929" description="Cytoplasmic envelopment protein 3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-myristoyl glycine; by host" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04041"/>
        </source>
    </evidence>
    <sequence length="77" mass="8469" checksum="E6BCF2D7637CDB02" modified="2007-01-23" version="3">MGAKCCKPVSCGMCKKTENTLIDYKGNPILLANEFTVLTDTESEEEGMADLEKPLLEKVVAKCDTEAEKKLPCKSKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2022-02-23" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>P28857</accession>
    <accession>Q69061</accession>
    <name>DPOL_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>DNA polymerase catalytic subunit</fullName>
            <ecNumber>2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U38</name>
        <name type="synonym">XILF0</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="4670" last="4680">
            <title>Characterization of the DNA polymerase gene of human herpesvirus 6.</title>
            <authorList>
                <person name="Teo I.A."/>
                <person name="Griffin B.E."/>
                <person name="Jones M.D."/>
            </authorList>
            <dbReference type="PubMed" id="1651403"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 778-1012</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7"/>
    <dbReference type="EMBL" id="M63804">
        <property type="protein sequence ID" value="AAA74631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B40898">
        <property type="entry name" value="DJBE6S"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042931.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P28857"/>
    <dbReference type="BindingDB" id="P28857"/>
    <dbReference type="ChEMBL" id="CHEMBL4009"/>
    <dbReference type="PRIDE" id="P28857"/>
    <dbReference type="GeneID" id="1487916"/>
    <dbReference type="KEGG" id="vg:1487916"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-1194">Viral DNA replication</keyword>
    <feature type="chain" id="PRO_0000046516" description="DNA polymerase catalytic subunit">
        <location>
            <begin position="1"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="1012" mass="115820" checksum="A9CB0BC3DC98731B" modified="1992-12-01" version="1">MDSVSFFNPYLEANRLKKKSRSSYIRILPRGIMHDGAAGLIKDVCDSEPRMFYRDRQYLLSKEMTWPSLDIARSKDYDHMRMKFHIYDAVETLMFTDSIENLPFQYRHFVIPSGTVIRMFGRTEDGEKICVNVFGQEQYFYCECVDGRSLKATINNLMLTGEVKMSCSFVIEPADKLSLYGYNANTVVNLFKVSFGNFYVSQRIGKILQNEGFVVYEIDVDVLTRFFVDNGFLSFGWYNVKKYIPQDMGKGSNLEVEINCHVSDLVSLEDVNWPLYGCWSFDIECLGQNGNFPDAENLGDIVIQISVISFDTEGDRDERHLFTLGTCEKIDGVHIYEFASEFELLLGFFIFLRIESPEFITGYNINNFDLKYLCIRMDKIYHYDIGCFSKLKNGKIGISVPHEQYRKGFLQAQTKVFTSGVLYLDMYPVYSSKITAQNYKLDTIAKICLQQEKEQLSYKEIPKKFISGPSGRAVVGKYCLQDSVLVVRLFKQINYHFEVAEVARLAHVTARCVVFEGQQKKIFPCILTEAKRRNMILPSMVSSHNRQGIGYKGATVLEPKTGYYAVPTVVFDFQSLYPSIMMAHNLCYSTLVLDERQIAGLSESDILTVKLGDETHRFVKPCIRESVLGSLLKDWLAKRREVKAEMQNCSDPMMKLLLDKKQLALKTTCNSVYGVTGAAHGLLPCVAIAASVTCLGREMLCSTVDYVNSKMQSEQFFCEEFGLTSSDFTGDLEVEVIYGDTDSIFMSVRNMVNQSLRRIAPMIAKHITDRLFKSPIKLEFEKILCPLILICKKRYIGRQDDSLLIFKGVDLVRKTSCDFVKGVVKDIVDLLFFDEEVQTAAVEFSHMTQTQLREQGVPVGIHKILRRLCEAREELFQNRADVRHLMLSSVLSKEMAAYKQPNLAHLSVIRRLAQRKEEIPNVGDRIMYVLIAPSIGNKQTHNYELAEDPNYVIEHKIPIHAEKYFDQIIKAVTNAISPIFPKTDIKKEKLLLYLLPMKVYLDETFSAIAEVM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2021-06-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>P28864</accession>
    <accession>Q69067</accession>
    <name>GB_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Envelope glycoprotein B</fullName>
            <shortName evidence="3">gB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gB</name>
        <name type="ORF">U39</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Virology" volume="197" first="449" last="454">
            <title>Identification and analysis of the transport/capsid assembly protein (tp/cap) gene of human herpesvirus-6 (HHV6).</title>
            <authorList>
                <person name="Jones M."/>
                <person name="Teo I."/>
            </authorList>
            <dbReference type="PubMed" id="8212582"/>
            <dbReference type="DOI" id="10.1006/viro.1993.1610"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-573</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="4670" last="4680">
            <title>Characterization of the DNA polymerase gene of human herpesvirus 6.</title>
            <authorList>
                <person name="Teo I.A."/>
                <person name="Griffin B.E."/>
                <person name="Jones M.D."/>
            </authorList>
            <dbReference type="PubMed" id="1651403"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 522-830</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans. Interacts with gH/gL heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Virion membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host cell membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host endosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="3">During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae glycoprotein B family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L20954">
        <property type="protein sequence ID" value="AAA03554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M63804">
        <property type="protein sequence ID" value="AAA74632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1989">
        <property type="entry name" value="VGBE6S"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042932.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P28864"/>
    <dbReference type="PRIDE" id="P28864"/>
    <dbReference type="DNASU" id="1487917"/>
    <dbReference type="GeneID" id="1487917"/>
    <dbReference type="KEGG" id="vg:1487917"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04032">
        <property type="entry name" value="HSV_GB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035377">
        <property type="entry name" value="Glycoprot_B_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035381">
        <property type="entry name" value="Glycoprot_B_PH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038631">
        <property type="entry name" value="Glycoprot_B_PH2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000234">
        <property type="entry name" value="Herpes_Glycoprot_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17416">
        <property type="entry name" value="Glycoprot_B_PH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17417">
        <property type="entry name" value="Glycoprot_B_PH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1032">Host cell membrane</keyword>
    <keyword id="KW-1039">Host endosome</keyword>
    <keyword id="KW-1040">Host Golgi apparatus</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-1161">Viral attachment to host cell</keyword>
    <keyword id="KW-0261">Viral envelope protein</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-1160">Virus entry into host cell</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000038186" description="Envelope glycoprotein B" evidence="3">
        <location>
            <begin position="23"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="topological domain" description="Virion surface" evidence="3">
        <location>
            <begin position="23"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="3">
        <location>
            <begin position="710"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in fusion and/or binding to host membrane" evidence="3">
        <location>
            <begin position="98"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in fusion and/or binding to host membrane" evidence="3">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic membrane proximal region" evidence="3">
        <location>
            <begin position="634"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic membrane proximal region">
        <location>
            <begin position="644"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Internalization motif" evidence="3">
        <location>
            <begin position="822"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by host furin" evidence="2">
        <location>
            <begin position="399"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="3">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="3">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="41"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="58"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="131"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="290"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="510"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04032"/>
        </source>
    </evidence>
    <sequence length="830" mass="93239" checksum="93DC01BCAE854A76" modified="1996-10-01" version="2" precursor="true">MSKMAVLFLAVFLMNSVLMIYCDPDHYIRAGYNHKYPFRICSIAKGTDLMRFDRDISCSPYKSNAKMSEGFFIIYKTNIETYTFPVRTYKKELTFQSSYRDVGVVYFLDRTVMGLAMPVYEANLVNSHAQCYSAVAMKRPDGTVFSAFHEDNNKNNTLNLFPLNFKSITNKRFITTKEPYFARGPLWLYSTSTSLNCIVTEATAKAKYPFSYFALTTGEIVEGSPFFNGSNGKHFAEPLEKLTILENYTMIEDLMNGMNGATTLVRKIAFLEKADTLFSWEIKEENESVCMLKHWTTVTHGLRAETNETYHFISKELTAAFVAPKESLNLTDPKQTCIKNEFEKIINEVYMSDYNDTYSMNGSYQIFKTTGDLILIWQPLVQKSLMFLEQGSEKIRRRRDVGDVKSRHDILYVQLQYLYDTLKDYINDALGNLAESWCLDQKRTITMLHELSKISPSSIVSEVYGRPISAQLHGDVLAISKCIEVNQSSVQLHKSMRVVDAKGVRSETMCYNRPLVTFSFVNSTPEVVPGQLGLDNEILLGDHRTEECEIPSTKIFLSGNHAHVYTDYTHTNSTPIEDIEVLDAFIRLKIDPLENADFKVLDLYSPDELSRANVFDLENILREYNSYKSALYTIEAKIATNTPSYVNGINSFLQGLGAIGTGLGSVISVTAGALGDIVGGVVSFLKNPFGGGLMLILAIVVVVIIIVVFVRQRHVLSKPIDMMFPYATNPVTTVSSVTGTTVVKTPSVKDVDGGTSVAVSEKEEGMADVSGQVSDDEYSQEDALKMLKAIKSLDESYRRKPSSSESHASKPSLIDRIRYRGYKSVNVEEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-12-01" modified="2021-06-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>P28865</accession>
    <accession>Q69060</accession>
    <name>NEC1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear egress protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NEC1</name>
        <name type="ordered locus">U37</name>
        <name type="ordered locus">XIRF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="4670" last="4680">
            <title>Characterization of the DNA polymerase gene of human herpesvirus 6.</title>
            <authorList>
                <person name="Teo I.A."/>
                <person name="Griffin B.E."/>
                <person name="Jones M.D."/>
            </authorList>
            <dbReference type="PubMed" id="1651403"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-264</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterohexameric complex with NEC2. Interacts with capsid vertex specific component 2/CVC2; this interaction directs the capsid to the host inner nuclear membrane to initiate budding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus inner membrane</location>
        </subcellularLocation>
        <text evidence="1">Remains attached to the nucleus inner membrane through interaction with NEC2.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated at serine residues in the N-terminus. This phosphorylation regulates the localization within the inner nuclear membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae NEC1 protein family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16744" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16744.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M63804">
        <property type="protein sequence ID" value="AAA74630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09331">
        <property type="entry name" value="QQBE6S"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042930.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P28865"/>
    <dbReference type="PRIDE" id="P28865"/>
    <dbReference type="DNASU" id="1487915"/>
    <dbReference type="GeneID" id="1487915"/>
    <dbReference type="KEGG" id="vg:1487915"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04023">
        <property type="entry name" value="HSV_NEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021152">
        <property type="entry name" value="Herpes_UL31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02718">
        <property type="entry name" value="Herpes_UL31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000116008" description="Nuclear egress protein 1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CCCH-type" evidence="1">
        <location>
            <begin position="83"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="264" mass="30845" checksum="5A0D8D66F01AAF94" modified="1996-10-01" version="2">MTVHKSRIRRSRSLSVTHRIQKRPDHREKTKLYLQLKLHDLHTVFNLFPEYEQKFLAIIKLPITGKEPIDVPFSLSNHHQHTCLEFSPYANEQISKSACLHCESVSVPTSSDAMVAHLNQVNNVMQNRLYFYGFRKDMELIRMSAKQPTIFQIFYIVHNTINNIFPIMFERKQKLGMHIVFQSRTLHIPCECIKQIVAVSSGYNVYLDILQESVILTVLCETLDTNTNIHIDIGMLQKKLEEMDIPNEISDRLEKYKGHLIGFH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-02-23" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>P52338</accession>
    <name>DNBI_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Major DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">DBP</name>
        <name type="synonym">U41</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text>Single-stranded DNA-binding protein required for DNA replication.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooligomers. Forms double-helical filaments necessary for the formation of replication compartments within the host nucleus. Interacts with the origin-binding protein. Interacts with the helicase primase complex; this interaction stimulates primer synthesis activity of the helicase-primase complex. Interacts with the DNA polymerase. Interacts with the alkaline exonuclease; this interaction increases its nuclease processivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">In the absence of DNA replication, found in the nuclear framework-associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae major DNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="X92436">
        <property type="protein sequence ID" value="CAA63167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042934.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52338"/>
    <dbReference type="PRIDE" id="P52338"/>
    <dbReference type="GeneID" id="1487919"/>
    <dbReference type="KEGG" id="vg:1487919"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04007">
        <property type="entry name" value="HSV_DNBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035989">
        <property type="entry name" value="DBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043031">
        <property type="entry name" value="Viral_ssDBP_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000635">
        <property type="entry name" value="Viral_ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00747">
        <property type="entry name" value="Viral_DNA_bp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118208">
        <property type="entry name" value="SSF118208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000115752" description="Major DNA-binding protein">
        <location>
            <begin position="1"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for nuclear localization" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04007"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127763" checksum="4468D3E5559F02D8" modified="1996-10-01" version="1">MADENETVVSAPVSTAAWIYVFPKDKELLDVLSVLSLMERNSPIVISPLLMNLTVENDFSTTVKTPITNFGGTILTKITSFMPVCFFFHGTEQLVGMAEDHGDLIRLCEQTRQKFHLQSFEVPTARKVIDIKALCSAVGKDADSVICHVACGNGFKELLFAGLLIPCVEEQIQVQVGEYSCVKIPLYSATLFETEETISLSSCTEFIQERGFFLPALSETLFYYVFTSWGTTLRFSNTKELIDAGLKQFTQDGEQTVKLAPHKTYLGISGQKISAVEKDFLMLVDSVVTELSFSHVAEYLDSVYDPSQIMNFNDWPIIRNSETHAERMAQLTNLKLHLSSHLAVLIFAPNSILYCSKLAFIPNVKQAFNSVMTQELLLRSLSFCNALSSLSDDVYNDNRKIIKCDSTSGKDDKFSANHLAYACATSPQLLSFVVWNLNRMSVYNAGNAHTEIYNHLVNCSANLCEFCDGKCCQSCIGTAMVRVGTRLPAIPKNVKKEPLVMSMFSRYYAEVDILGSFGRKPVSELKEIGKDQQNTLSLDRGKFVSQIFDYCKKNSLIDPVTGEDTFNVRSKKDFVSIIHGLTQCIEECVSRCIVEMRRTQTPREQIENCLQSFNVDTTPYATAFSPFLTFSYYKVILTVLQNLALIVASGHVVDRPCTGNSISKWLVQQYQSLYGTFHSSYLKKGFLNTRTVKVASNVDMEQILDCDLYKSGKYVKTTIQAKLCRLSMQCLRDFRIKNRPFNKSSKTAHNNPYFKKNVKHKKNPLSGCISFLLFKYHDKLFPNVKISCLELWQRFLLNNVPKTLDIGNPEEVKTFIKFAFSITNTYDEIDIIDIQPECLSTFIDCYFHNKFLSALGFHDYLTSLHGLTSKLVTQNPVLFPVVLDKQPKFSSIQEYLVYVKKLVLDGVPNPVIASLSKEPNFGTIFTSRSLVTFGLTLEKFVSLANREYFQFGQLGWIGGSGVDRNLNPTSSALQDFRFMRQKTIIATKFSEVIVKKVRREAIMFDTEVVKGKVLSIVENLTNDIDPELLIIAEVMRDREDKPTMDDMLFFVDGREALAASIMLKLNHLVDMNVKDFSITNLQSVFETVSSNDAPVYDFSEILAEEDDQGNGVLKCDETETETDEPMTKKNRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>P52340</accession>
    <accession>Q69055</accession>
    <name>LTP_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large tegument protein deneddylase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
            <ecNumber evidence="1">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U31</name>
        <name type="synonym">HHRF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins. Interacts with inner tegument protein. Interacts with capsid vertex specific component CVC2. Interacts with the major capsid protein/MCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Tightly associated with the capsid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae large tegument protein family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16739" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EC" id="3.4.22.-" evidence="1"/>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16739.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09326">
        <property type="entry name" value="T09326"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042924.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52340"/>
    <dbReference type="PRIDE" id="P52340"/>
    <dbReference type="GeneID" id="1487907"/>
    <dbReference type="KEGG" id="vg:1487907"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039648">
        <property type="term" value="P:modulation by virus of host protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04044">
        <property type="entry name" value="HSV_LTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006928">
        <property type="entry name" value="Herpes_teg_USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034702">
        <property type="entry name" value="HSV_LTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04843">
        <property type="entry name" value="Herpes_teg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51521">
        <property type="entry name" value="HTUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1127">Modulation of host ubiquitin pathway by viral deubiquitinase</keyword>
    <keyword id="KW-1130">Modulation of host ubiquitin pathway by virus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0788">Thiol protease</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-0920">Virion tegument</keyword>
    <feature type="chain" id="PRO_0000116041" description="Large tegument protein deneddylase">
        <location>
            <begin position="1"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C76" evidence="1">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Deubiquitination activity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with inner tegument protein" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1982"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="2077" mass="239947" checksum="C1CA4BDC26650511" modified="1996-10-01" version="1">MKIITSSTNQNDSKYGPRAGKQCMSNSFSFLHTVYLNGINNSLNAGTIDAIMEEGYHLDTAGTLALMLNNSDSQDYRLPTEIPKRIHSRYGVTQHELSRPFNGTLDTQKIDNEVYLGLIDFILYGKSKNGPTFAVITIGVLSRALFFLNNTLYLFDSHPTEREATAAIYICQNIEEVYELLTTHGTEGFYYDASLIFFIETSNLSLSSHDAELLILKTYKDPDIAIALDKFSSTEIHEIKKTDDIGSQQDLVADKTTDLEHAPHKRKKNSHSLELELNDKKKKDTASLTYYATEVDLIPSFYELRSQFQSLFHDLKSFPIMKSNFNWTIYLQDSPINPNQPFATPFLWNRVFHLLCQIIDVFVGVGSTNDDSSKQQQQTIFINYLLPFKDFSEVFNEALAACQENNLDIIFIYNNYLCKTTTFRTLERILLSKFLAIVDNDHKKHYEWVKSWTTQMFQGMPKKLDDIENYLKAYVDHNPVKHFHEFICLNKAEKYKVAVLLNEKRKEIQEAIEREKNSFAQLSNFIDKLGETPALPIESENVHKVHTSDITEGIVPRFITESIELPNISTLNNTQQISLDKQLNEKLTNTIHTLTNKFTKIVQDNYNNIAAGFMPVTELNCLFAYLVNLYFNIEVLKHSGLNINTVLLQEVEKLYDNTQFLRFGTSHFNINNLSNFTLSIRKMFVDFYNSQKPSDRASEILAAIESILADPSKNKTVVNIEMIKSQLEELGKMEISTTENKQTAAITKQILGDQELTPIYDFLHHLSAYNLPNTTTVKNLHLHFILEQRPDIAMTLHDKIQSILDIYVDDMLNDITVPEQTFSTVLFLVDLFPNSTEKTALFESVLTLRQLAKKCANLKTLDEFDDLAQFITTNSEQLQNMMRQHFGKKIPTLMGHIKFLYSQKIITTEEKNWIQRAKTVVITSPEELTAFLATAPTKHALQTCKPDLDKALQRHMEEQMKQTAENDKKHILTIRSTLEKRLTDILLILKDGQFSSLETMHLNLLETFLKQLQDNNVIIHFTHALLPVLKDIETTISKIISDVIEKILIKTPLNPEQMSKEEQKYTPLLSFLSKFKKTTFCTEDVKTEIEQVQKSITFLKKIATSTNKHTRLSHSIYGQELNLYEERITELRKETNKMKEQLSKEYALAEKKILLSSQDAKTDKIYLVLNTHTLKEIKNTQFKETAFAKALTVEVNNKENQLQELLNHFNAHLKAKMDQNHITKLSFDTKWTAFVSDSRLYIPDFINIKLQDFISDPFKVISQLMNKATNEMPYIQAEITLKWLTKLIHDINKFCLSAISEFGKEAIPFNYAALRDLEYQINTKYVEIENKVICNETVENTKNIPKLTKLLKQLDPKRVAGGQEQYQTLMNKILTSETSMQQTYEKEQLKKEYFEIVNNVASFKLAFNFPQQLQNVERLIEKFKSLPKSQPFEKFPQENDLLSDSLNTENYINGLRALLNFITAAQNYIQNTLLKQWAVFQQQNFIPIDYSVANVKPISDLYARLRIERERQVFYQVNSVFGTHLIVDDTGVPLQFHNIFNNAIVKFFSLNYKQINVPEDTPRLVSSQYKLLSVCKSFIMILQQFWENIITLDLGPYLRDGTQNFKRELIPIVNLKLFIYCITQAWTASEDSTVSTAFELPIKQFTLLILCSHPEYLYGCLSHSTDLVINSLAKSIDKNSLYNTFVVSHNPPEKPMHLMRNICIDTQLWQPAKLMKDTFQQTFFTQLCPKNEKFFIYLTAFLILPYKFMNYIWIQYKPAIFTQRSYQNLIKDLCSEYVHQNKITTSSVTPHEPDTIKSGERITSKITVHKAQNTPTLTRLQAQEYVFDYILYSFLTGYEMTFAMYIDIIEKTYLLCMRHLENVLHDKDFQSVLRARTFDIDYILKQSWTKNIVEHSLFSVQLDKIVSYLNHTNRATPNIPLILFNYDNEVVNVYLPPMSTNPKKVAFYIKNPFHFPVQEYEATNLISFHLYPKTTDILNQLPPNNTESTRPGKQTSETLTNKNLSEPKFKKPAVTGLMPKSQSIILSTDTNVPETSPDVKANTASAAIKDVTLAREKINEFSESINTTISKLKSMYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>P52343</accession>
    <accession>Q89941</accession>
    <name>RIR1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonucleoside-diphosphate reductase large subunit-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RIR1</name>
        <name type="synonym">P2LF2</name>
        <name type="synonym">U28</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="J. Gen. Virol." volume="80" first="2713" last="2718">
            <title>The U28 ORF of human herpesvirus-7 does not encode a functional ribonucleotide reductase R1 subunit.</title>
            <authorList>
                <person name="Sun Y."/>
                <person name="Conner J."/>
            </authorList>
            <dbReference type="PubMed" id="10573165"/>
        </citation>
        <scope>ABSENCE OF RIBONUCLEOTIDE REDUCTASE ACTIVITY</scope>
        <scope>ABSENCE OF GENE FOR SMALL SUBUNIT</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2009" name="Trends Biochem. Sci." volume="34" first="25" last="32">
            <title>Tinkering with a viral ribonucleotide reductase.</title>
            <authorList>
                <person name="Lembo D."/>
                <person name="Brune W."/>
            </authorList>
            <dbReference type="PubMed" id="18990579"/>
            <dbReference type="DOI" id="10.1016/j.tibs.2008.09.008"/>
        </citation>
        <scope>REVIEW</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks the conserved sequence Asn-x-Cys-x-Glu essential for ribonucleotide reductase activity.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16736" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16736.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09323">
        <property type="entry name" value="T09323"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042921.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52343"/>
    <dbReference type="PRIDE" id="P52343"/>
    <dbReference type="DNASU" id="1487905"/>
    <dbReference type="GeneID" id="1487905"/>
    <dbReference type="KEGG" id="vg:1487905"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044423">
        <property type="term" value="C:virion component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04027">
        <property type="entry name" value="HSV_RIR1_betahv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034716">
        <property type="entry name" value="HSV_RIR1_betahv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-0426">Late protein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000187238" description="Ribonucleoside-diphosphate reductase large subunit-like protein">
        <location>
            <begin position="1"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="804" mass="93353" checksum="E01A17F36B571EAE" modified="1996-10-01" version="1">MKRKERRINKDYGYNRKCVCHYEASQKRFCYSQYSCASVLYERVRDIAKIIDRLDSGLDAWCLRDAIISVLRATHCVPRVDRMLGRWYLKTSVFYDFCPDDLILSCPNVIMPNVLNFVKKYRDFIRSVLYKVSVSWKNQYMPGVLAASRFLEEISNSLNGVEESIPCIYLRMCATLTEIVLRIGYLREIYQENPYVMFEELAFSLFTQKWVLPFSCMTNLGLVEKANSTVFDVAIYNTCLYSLVDFTIVNGEHLFPALLNGSNISMNLTRYQQEAKNIFEILLSQIRVVERDTDKTVQLTVYVEVWHVSALMWLDLYEALPQTSRVTFCLIIPGIFMDRYELKRAQWSLFHKNIAFELGKCDEITFSTKYLEFERTTDHAKITMSSFIEKICLCLKGGRMGLIFRKNVYQYSMIPHVPLYCGGDFLDVLPVRDGINTCMRMLLNVVHFLGDEVSDELTEEIDFVRLQCKFFMFNELRRVVRKMVLVANAVIDYAVENKDFLCEGIEDGRSLGICVTGLHSVFMTVGLSYAHPDARRLYRMICEHIYYTCVRTSVDCCMKGAEPCNLFDRSKYALGMLYFDHFDNVECTLPEELWTTLRKDVLMHGVRNIHFTAGTAMQKEFDIINSSESFWPMEDNKILRRSNIKVVIGKDGLNDVTSVYSSELKSLYIPVYNNLLLNRFNKHQQYLKTVGYRVLNVDTNLFTDKELDDLAVFKDGFSYHLNDLIEMYKSGLPFLDQGQANVFYFNDTVSLRLLLPLLYKAGFKVAMYKVLCNSEMYKHLDLSNPLPLIGKCSDGVVMHVKNIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>P52345</accession>
    <name>UNG_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil-DNA glycosylase</fullName>
            <shortName evidence="1">UDG</shortName>
            <ecNumber evidence="1">3.2.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UNG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">U81</name>
        <name type="synonym">EDLF4</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="1"/>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042974.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52345"/>
    <dbReference type="PRIDE" id="P52345"/>
    <dbReference type="DNASU" id="1487961"/>
    <dbReference type="GeneID" id="1487961"/>
    <dbReference type="KEGG" id="vg:1487961"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176188" description="Uracil-DNA glycosylase">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04046"/>
        </source>
    </evidence>
    <sequence length="255" mass="29038" checksum="F7DB5959BD9D0A48" modified="1996-10-01" version="1">MALLQWMLDHVQDEEKNCENLSIDDQHSLFGINRDWLSFLQLSKLEITHLKHVYKLVDNDRAHLMVHPSSDNVHAWSFLCKPDNVKVVILGQDPYPDGRGCGLAFGTVKECSIPESLKNIFKELERSVPNFSPPDNGCLNSWCSEGVLLLNSIFTVVHGLPMSHEAFGWQTLSYKIISKLSVEMDSLVFLLWGNHARKLSYLIDARKHLVLESAHPSPKVKSARMPFIGCNHFVRANLFLTEHGKDPINWNILNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>P52348</accession>
    <accession>Q69053</accession>
    <name>TRX1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triplex capsid protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRX1</name>
        <name type="ordered locus">P2LF1</name>
        <name type="ordered locus">U29</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with TRX2, MCP and capsid vertex component 2/CVC2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae TRX1 protein family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16737" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAA16737" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16737.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09324">
        <property type="entry name" value="T09324"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042922.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52348"/>
    <dbReference type="PRIDE" id="P52348"/>
    <dbReference type="DNASU" id="1487906"/>
    <dbReference type="GeneID" id="1487906"/>
    <dbReference type="KEGG" id="vg:1487906"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04018">
        <property type="entry name" value="HSV_TRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004999">
        <property type="entry name" value="Herpes_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03327">
        <property type="entry name" value="Herpes_VP19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0167">Capsid protein</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000115719" description="Triplex capsid protein 1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="299" mass="34206" checksum="CF6DC52418F57558" modified="1996-10-01" version="1">MNSKSSARAAIVDTVEAVKKRKYISIDEGTLNNVVEKERKFLKQFLSGRQNLRIAARVFTPCELLAPELENLGMLMYRFETDVDNPKILFVGLFFLCSNAFNVSTCVRTALTAMYTNSMVDNVLSMINTCRYLEDKVSLFGVTSLVSCGSSCLLSCVMQGNVYDVNKENIYGLTVLKEIILEPDWEPRQHSTQYVYVVHVYKEVLAKLQYGIYVVLTSFQNEDLIVDILRQYFEKERFLFLNYLINSNTTLSYFGSVQRIGRCATEDIKSGFLQYRGITLSVIKLENIFVDLSEKKVFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>P52354</accession>
    <name>ICP27_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>mRNA export factor ICP27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">U42</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Host cytoplasm</location>
        </subcellularLocation>
        <text>Shuttles between host nucleus and cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HHV-1 ICP27 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X92436">
        <property type="protein sequence ID" value="CAA63168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042935.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52354"/>
    <dbReference type="PRIDE" id="P52354"/>
    <dbReference type="GeneID" id="1487920"/>
    <dbReference type="KEGG" id="vg:1487920"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019033">
        <property type="term" value="C:viral tegument"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008648">
        <property type="entry name" value="ICP27-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05459">
        <property type="entry name" value="Herpes_UL69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-0920">Virion tegument</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000115828" description="mRNA export factor ICP27 homolog">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="2">
        <location>
            <begin position="230"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA58376." evidence="4" ref="1">
        <original>QLD</original>
        <variation>HC</variation>
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P10238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="515" mass="59886" checksum="22AE3A86D6C43491" modified="1996-10-01" version="1">MYPRGVKRSHHDYHRQTAFRTIKRSTHRQTSKFISHFAKNFRGKLAPLKQLDESRLDALSLTELEQLKTIIEEKQQEKRAQNNAITFLPNLPTVPFADTNFSLKSLGLRPYNGDARDPKQRIRDRFPQTHERICLLTNDILETDLLLRYRQCLDSLTREENQQLMGDRIFSLTNSPCLAFTVATVEEACSYFKFHDLHNLPVNPQDLFMYTITVMKFEFFNKLNMAKLTCVFNDNGHGDIEYRKLRQLCGKPVLDREMPNSELEVQQQTPDSFRHPIQQAMSIVVTFARILRQIKEQIIQTKKPQFIRDFDTGRVAERYECGLMSRLIGKQFSNHKCDDVSCQNRIERIMAPWKPSLFFCTYFAKDAPKFKLFPNFPEEYRNLSFTCPKVDTEPSCSYSTNHDLPQTSHRSHKNHGTPKVKSKVCVEKPDTSILTTTKTTTEILIEESMETDNKIPNPRELNFNQAKQEEIVIININENVNSKHESESSVEMDLDLDYEADTCETNLNACSSDSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>P52356</accession>
    <name>HELI_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication helicase</fullName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HELI</name>
        <name type="ordered locus">HDRF2</name>
        <name type="ordered locus">U77</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs. Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the primase and the primase-associated factor to form the helicase-primase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042970.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52356"/>
    <dbReference type="GeneID" id="1487959"/>
    <dbReference type="KEGG" id="vg:1487959"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039686">
        <property type="term" value="P:bidirectional double-stranded viral DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04030">
        <property type="entry name" value="HSV_HELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003840">
        <property type="entry name" value="DNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034711">
        <property type="entry name" value="HSV_HELI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02689">
        <property type="entry name" value="Herpes_Helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000115849" description="DNA replication helicase">
        <location>
            <begin position="1"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04030"/>
        </source>
    </evidence>
    <sequence length="824" mass="93287" checksum="5A5507544E06184C" modified="1996-10-01" version="1">MSISSLFGGRYDNKFLLNMSSAPKIELIVDKVASLSERRLEGRLPEDWFRHIMDPETEFNSEFADALCIGIDEFAQPLPFLPFKALLVTGTAGAGKTNSIQTLAANLDCIVTATTSIAAQNLSVVLNRSKSAQVKTIFKTFGFNSSHVSMSERQSYIANDERSIQIQQKQDLSIYWNVISDIADRALGAVACKTKELPDLCESSVIVIDEAGVILRHILHTVVFFYWFYNALYKTPLYEDGIVPCIVCVGSPTQSNALVTSFNPLTQNKDVKRGIDVLSALICDDVLSKYCEVDNNWIIFVNNKRCADHAFGDFLKHIEFGLPLKPELIEYVDQFVKPASYIRNPMNEIETTRLFLSHNEVKNYFRSLHEQVEVTNRNNLFVFPVYFLIKNKTFEDYKSEIGNFSLEIEPWFKSNIHRLNTYSQFADQDLSKTVQLEEIVLEDGSVEETLITCHLKHIRNSSIGVTSKIKASTVGFSGTYEKFVELLQSDLFIEKTSCDQTIHAYSFLSGLMFGGMYSFCCSKFTTPEVLMEIKNIKMPSIEFLESEMSRMSPDVQTVETDERYDFGLVNDGLSDVDLLEIDPCGDPFFTRYSKLPLTNSLSFEEISLLYTTFKDIFISRFAILQKHTKGKFGKTLLVTYNRNNVSRKQCGEIYSHLKSFYGMLTYAIPANNYTLEGYTNDNVVHLGTDKQLPQILYKKGLPRLVIKDEMGFISVLDNNVSKFIDVVNGQSFHLCTTVDYATVSKVSMTITKSQGLSIQKVAIDFGSDPKNLKLSSIYVGMSRVTDPNNLIMNVNPLRLNYENDNFIAPHIVKALKNENTMLIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>P52375</accession>
    <name>HEPA_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase/primase complex-associated protein</fullName>
            <shortName evidence="1">HEPA</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Primase-associated factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">U74</name>
        <name type="synonym">HDRF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the primase and the helicase to form the helicase-primase complex. Interacts with the origin-binding protein. Interacts with the polymerase catalytic subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae HEPA family.</text>
    </comment>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042967.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52375"/>
    <dbReference type="DNASU" id="1487955"/>
    <dbReference type="GeneID" id="1487955"/>
    <dbReference type="KEGG" id="vg:1487955"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04010">
        <property type="entry name" value="HSV_HEPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004996">
        <property type="entry name" value="HSV_HEPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03324">
        <property type="entry name" value="Herpes_HEPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000115861" description="DNA helicase/primase complex-associated protein">
        <location>
            <begin position="1"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04010"/>
        </source>
    </evidence>
    <sequence length="662" mass="76316" checksum="2E29BBAF108F7621" modified="1996-10-01" version="1">MHLRGCACHLSLYCVYNDWENKIYRVPIFQCLFLEAETRSLKTFLIRGQSLDQESLNEIEVTRKETMLWDLQEQSNMMDKKIAAISNLIMNNGELVRTLSKFFVPLTVVLGDDGLEILEAYVCGEELMLPLDTVPVILRCIGDYAALDTKHLLSNECTQASKKIRFGYSVMDFHFSLTVSDVKICFSHTDTGEAVCEKMKQIFSFSVCAFGGEQVLLVTPKNAYALLFDDDLCLLLLQSVFAFLHEKIFGVYKQVLVQLCEYIGPDLWPFGNERSVSFIGYPNLWLLSVSDLERRVPDTTYICREILSFCGLAPILGPRGRHAVPVVRELSIEMPGSETSLQRFRFNSQYVSSESLCFQTGPEDTHLFFSDSDMYVVTLPDCLRLLLKSTVPKAFLPCFDENATEIDLLLKFMSRLQHRSYALFDAVIFMLDAFVSAFQRACTLMGMRWLLVRDLHMFYLTCDGKDTHVVMPLLQTAVENCWEKTTEIKQRPTFQCAEISRCGFIVYARFFLSSGLSQSKEAHWTVTASKYLSACIRTNKTGLCFASITVYFQDMMCVFIANRYNVSYWIEEFDPNDYCLEYHEGLLDCSRYTAVMSEDGQLVRQARGIALTDKINFSYYILVTLRVLRRWVESKFEDVEQTQFIRWENRMLCEHIHLLHLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>P52378</accession>
    <name>OBP_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Replication origin-binding protein</fullName>
            <shortName>OBP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U73</name>
        <name type="synonym">19R</name>
        <name type="synonym">HDRF0</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="J. Gen. Virol." volume="76" first="147" last="152">
            <title>Human herpesvirus 6 (strain U1102) encodes homologues of the conserved herpesvirus glycoprotein gM and the alphaherpesvirus origin-binding protein.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Nicholas J."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="7844524"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-703</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in DNA replication. Binds the origin of replication (ori).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae OriBP family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042966.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52378"/>
    <dbReference type="DNASU" id="1487954"/>
    <dbReference type="GeneID" id="1487954"/>
    <dbReference type="KEGG" id="vg:1487954"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003450">
        <property type="entry name" value="Replication_origin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02399">
        <property type="entry name" value="Herpes_ori_bp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000115870" description="Replication origin-binding protein">
        <location>
            <begin position="1"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="780" mass="89717" checksum="53F4B0E46C9BCB5F" modified="1996-10-01" version="1">MENRFQNDTLFSEWFGQSLSDVRFPDNVTVYSQADSAVSFENVRQPIKLVRAAMGSGKTTALIHFLKQVPRELSVLLISCRKTFAAEILHRFTLNGLKDFELYCDITERQINNRKVIVQIESLHRLTENYDVLILDEIMSIIKQFYSKTMTKTKEVDCKFLSLIKNSSHVIAMDATLTRHVVEFFAAFKPDTQIALIRNTFVSAMFSNRIAYFCDTFFGKEFSFFARLEDKLRWDKKLCLFCSTVLAAEYMYDLIRSRFPLKKVLLLTSKQGKCSSIESWIRYDVVIYTSVVTVGLSFEPVYFSSLFVYIQLAKGGPDMVSVFQSIGRVRRVIDEDIYIYMNPVLIRSYDPLAPIAIPPCSDWSVAEQSIISESCIDFRGKCSGAHKYNFCSVLKSLFRYRHYIEKTTITSLSDSLFLLCSLLCENSIKVDIVGNGFPMRKEVFLSFLQILVEECHFIEKKITLPGDDMTFQEIISSRETIMNGDFYENGDQLLHKDYITDMGKFRATFLSPGVDIFIASDIVYDLKNESKRYVFVNVWLQKCVSAGVESTEIERVFCERIKCYMLPKSFLCDEYFVLGDISGVYEWGMLIDLAFLAEMIRKDLKLKSCTDTTTDISEDDLLLCAARRSSDILQIMQLVFTVHVQFFQKYSLQTLQLFNKLRGMRIVTGVFSIEKFSISILRLFFKCAFNMTLSASRPRYIPGKAYRNLTKNDMENMLDNWEISRTNLKTCKELRKALTEASRARRKQTIYKLQGSDISLSVSEVGVFGQHASPGVCVSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-02-23" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>P52380</accession>
    <accession>Q69547</accession>
    <name>UL33_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>G-protein coupled receptor homolog U12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U12</name>
        <name type="synonym">P1RF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text>Probable G-protein coupled receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">It is uncertain whether Met-1 or Met-30 is the initiator.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="P52380"/>
    <dbReference type="PRIDE" id="P52380"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0297">G-protein coupled receptor</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0675">Receptor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0807">Transducer</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000070241" description="G-protein coupled receptor homolog U12">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=7" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="347" mass="39746" checksum="33DA730AD9059821" modified="1996-10-01" version="1">MDTVIELSKLQFKGNASCTSTPTLKTARIMESAVTGITLTTSIPMIIIVVTTMILYHRVAKHNATSFYVITLFASDFVLMWCVFFMTVNRKQLFSFNRFFCQLVYFIYHAVCSYSISMLAIIATIRYKTLHRRKKTESKTSSTGRNIGILLLASSMCAIPTALFVKTNGMKKTGKCVVYISSKKAYELFLAVKIVFSFIWGVLPTMVFSFFYVIFCKALHDVTEKKYKKTLFFIRILLLSFLLIQIPYIAILICEIAFLYMPQNTCFWLARVEILQLIIRLMPQVHCFSNPLVYAFTGGELRNRFTACFQSFFPKTLCSTQKRKDSDASEHDQNSKSKASVEKNQPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>P52382</accession>
    <name>VU51_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>G-protein coupled receptor homolog U51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U51</name>
        <name type="synonym">XKRF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Host cell membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042944.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52382"/>
    <dbReference type="DNASU" id="1487931"/>
    <dbReference type="GeneID" id="1487931"/>
    <dbReference type="KEGG" id="vg:1487931"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0297">G-protein coupled receptor</keyword>
    <keyword id="KW-1032">Host cell membrane</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0675">Receptor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0807">Transducer</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000070256" description="G-protein coupled receptor homolog U51">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=7" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00521"/>
        </source>
    </evidence>
    <sequence length="301" mass="34714" checksum="D6CE380C6F9F33EE" modified="1996-10-01" version="1">MEKETKSLAWPATAEFYGWVFIFSSIQLCTMVLLTVRFNSFKVGREYAVFTFAGMSFNCFLLPIKMGLLSGHWSLPRDFCAILLYIDDFSIYFSSWSLVFMAIERINHFCYSTPLLNENSKALAKVCFPIVWIISGVQALQMLNNYKATALQNETPQCFLAFLRSGYDMWLMLVYSVMIPVMLVFIYIYSKNFMLLKDELSTVTTYLCIYLLLGTIAHLPKAGLSEIESDKIFYGLRDIFMALPVLKVYYIPVMAYCMACDDHTVPVRLCSIWLVNLCKKCFSCTRREKESDLEVGIKMLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>P52384</accession>
    <name>TRM1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tripartite terminase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRM1</name>
        <name type="ordered locus">U40</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with TRM2 and TRM3 to form the tripartite terminase complex. Interacts with portal protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae TRM1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X92436">
        <property type="protein sequence ID" value="CAA63166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042933.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52384"/>
    <dbReference type="PRIDE" id="P52384"/>
    <dbReference type="DNASU" id="1487918"/>
    <dbReference type="GeneID" id="1487918"/>
    <dbReference type="KEGG" id="vg:1487918"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019073">
        <property type="term" value="P:viral DNA genome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04014">
        <property type="entry name" value="HSV_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000501">
        <property type="entry name" value="UL28/UL56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01366">
        <property type="entry name" value="PRTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0426">Late protein</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0231">Viral genome packaging</keyword>
    <keyword id="KW-1188">Viral release from host cell</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000115882" description="Tripartite terminase subunit 1">
        <location>
            <begin position="1"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="626"/>
            <end position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04014"/>
        </source>
    </evidence>
    <sequence length="726" mass="82878" checksum="B735E3F0EAD597B5" modified="1996-10-01" version="1">MNSLQSLCVLCARLNECALDLECLKFCDPVIVLSDMANFKKNGIVILHLYQTFFEGIKEQNLLCASALTVYMQVLLKAMYEQVLLLDAALESFMVDQDRKKYFEKVLCLRRCAETLSINISLNNGVEFIVQLSTLNDIEQLISKINSVYALLLPQEGLQICGKIIDLLTIMCGACMVAKPESYLETKTCMKCYEELTLTPNQGKSLRRRLHGKFCNHLTEQKAFFNIEKNIETIEKDLGEAILNYGTVQSVATEIKKIFKQQRSAESLHVSDAEKTLKKYNIFSKVPDVIYSLSEFTYWSKISETIVRNVAITLQQLNSCHTLYKQLQNDVSLYLYGEVSEDFLALSENLLTHDERLYVGSIYVSPSRLIDLVTGLSIKNLEESPIFKRLAEEDEVQHKIKSLLHDIRDPQTTETPGRLNTINCMLQTHNLQQEVLARKKAYFQKVSESGYNRVMACIREQESLINKVVSVNVYGNFIFEALSKIMNGFVLRKMYLDGSFRVDSCTYDEHLYIKNNLMPKKLPLELLPDLSEIMYTLLTGPLSDFHKSAYPLPANISMAYGCDHAEMLPHMKEDLARCIEGTIHPSVWMVCEYNEFFNFSGVTDVNDMQKKMWNFIRELTLSVALYNDVFGKRLKIVRIDEEGDLSGNVVLTFNHESPLLFHTGGGMTKFKDVYSLLYCDLQAQLSRETVDVPEGVSYSVRTPNLLDLVRENEQDGSIIPGCLFDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-02-23" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>P52387</accession>
    <name>CVC2_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Capsid vertex component 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CVC2</name>
        <name type="ORF">BHRF3</name>
        <name type="ORF">U50</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carss A.L."/>
                <person name="Sun N."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1333836"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae CVC2 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X64320">
        <property type="protein sequence ID" value="CAA45605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042943.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52387"/>
    <dbReference type="PRIDE" id="P52387"/>
    <dbReference type="DNASU" id="1487930"/>
    <dbReference type="GeneID" id="1487930"/>
    <dbReference type="KEGG" id="vg:1487930"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04025">
        <property type="entry name" value="HSV_CVC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002493">
        <property type="entry name" value="Herpes_UL25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01499">
        <property type="entry name" value="Herpes_UL25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0167">Capsid protein</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0231">Viral genome packaging</keyword>
    <keyword id="KW-1163">Viral penetration into host nucleus</keyword>
    <keyword id="KW-1188">Viral release from host cell</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-1160">Virus entry into host cell</keyword>
    <feature type="chain" id="PRO_0000115998" description="Capsid vertex component 2">
        <location>
            <begin position="1"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with major capsid protein/MCP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04025"/>
        </source>
    </evidence>
    <sequence length="555" mass="63594" checksum="BA0C879FF56130D4" modified="1996-10-01" version="1">MAQCNLFYQYPITPILEGHVRNILICTEKDVEKLQSQSSLRLREKIDQGHRDKLLRMRLKTELDALQKKMQKDSDVLNSHLKAIEDALLFTNDGEVNVETKADAQLIPKSPEKLEKFNQVAITPLDPFIRFTDDFRGEMINTFFNNAQMWNFTFGSWFYKLKRVFYNEPGLRRALKLTNVDSLTISKELLAVTVNALEQATVYPIFGSEMSDLEAALCILAAFYSTYENSQIDERTTLVDVITLLPVIFRLLGSEITALKNVSPSGTYFGFNDPSCMKFFVPMRKGKHYAENTFGNHVLIKMLLGRGVMQKIPGEKISQNFDVEARLHGAIKNDVLVYWTYQLMRPKLGNNVPIFIHDQHYLRSGLVAIESLFLLWRILNSESLFNKRVGKFLLTSIFPQLENVDFAENNFEAGNIQNFEYLMHHYVVPMYNLQNDISISTLFPGLVAVCVNESVRLGWEHKCAGAPSDAVQVQSKENPFVEYIRAQMEQQADVAILEKHDCILFHLENGLNITLSFTLPRQRLFAMASSLFNVNDTYDFIYFLVLGFLPIPAVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>P52439</accession>
    <accession>Q69052</accession>
    <name>VPAP_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>DNA polymerase processivity factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Phosphoprotein P41</fullName>
            <shortName>PP41</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Polymerase accessory protein</fullName>
            <shortName>PAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">U27</name>
        <name type="synonym">EPLF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the DNA polymerase that acts to increase the processivity of polymerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae polymerase accessory protein family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16735" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16735.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09322">
        <property type="entry name" value="T09322"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042920.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52439"/>
    <dbReference type="PRIDE" id="P52439"/>
    <dbReference type="DNASU" id="1487904"/>
    <dbReference type="GeneID" id="1487904"/>
    <dbReference type="KEGG" id="vg:1487904"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004997">
        <property type="entry name" value="Herpes_PAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03325">
        <property type="entry name" value="Herpes_PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116066" description="DNA polymerase processivity factor">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="393" mass="44810" checksum="239ADFF63F645D90" modified="1996-10-01" version="1">MCWSFHLFFKAHKARVGARTSFLTEMERGSRDHHRDHRDHREHRETREPPTLAFHMKSWKTINKSLKAFAKLLKENTTVTFTPQPSIIIQSAKNHLVQKLTIQAECLFLSDTDRFLTKTINNHIPLFESFMNIISNPEVTKMYIQHDSDLYTRVLVTASDTCTQASVPCVHGQEVVRDTGRSPLRIDLDHSTVSDVLKWLSPVTKTKRSGKSDALMAHIIVQVNPPTIKFVTEMNELEFSNSNKVIFYDVKNMRFNLSAKNLQQALSMCAVIKTSCSLRTVAAKDCKLILTSKSTLLTVEAFLTQEQLKEESRFERMGKQDDGKGDRSHKNDDGSALASKQEMQYKITNYMVPAKNGTAGSSLFNEKEDSESDDSMHFDYSSNPNPKRQRCVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>P52444</accession>
    <name>VU26_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U26</name>
        <name type="synonym">EPLF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042919.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52444"/>
    <dbReference type="DNASU" id="1487902"/>
    <dbReference type="GeneID" id="1487902"/>
    <dbReference type="KEGG" id="vg:1487902"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009980">
        <property type="entry name" value="Herpes_U26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07402">
        <property type="entry name" value="Herpes_U26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000116286" description="Protein U26">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="295" mass="33335" checksum="282A85F108DA60DC" modified="1996-10-01" version="1">MRRLTDSFILGLAKGAVIPGLYTFRMTEGRSPLGQIGVLITVAISFLLTFKRFDPRFYKPIGDFKIVFLSLMAPKLPSLLSAVVMICLIFSEMRLRMILSRCVMIMPSYSPAVFTGIMVSLFFKSQMFDDYSVLITAASLLPITVRYGWMIRSSGFLLGLQKYRPILKSTSFREVDLKCLVKFTVEFLLLFTMLWIGKMFLSMPKSNHLFFLTVVNNVFFKLNVFKAAACAVVAILSGLMMNVCLYRIIFEAFVGLGFSSIMLTLSSDLKDRSFYAGDLLNGFFCLVVCCMYFGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>P52453</accession>
    <name>PORTL_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Portal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U76</name>
        <name type="synonym">HDLF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamerizes. Interacts with terminase subunits TRM1 and TRM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae portal protein family.</text>
    </comment>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042969.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52453"/>
    <dbReference type="PRIDE" id="P52453"/>
    <dbReference type="DNASU" id="1487958"/>
    <dbReference type="GeneID" id="1487958"/>
    <dbReference type="KEGG" id="vg:1487958"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044423">
        <property type="term" value="C:virion component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04012">
        <property type="entry name" value="HSV_PORTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002660">
        <property type="entry name" value="Herpes_Portal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01763">
        <property type="entry name" value="Herpes_UL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0231">Viral genome packaging</keyword>
    <keyword id="KW-1188">Viral release from host cell</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000115907" description="Portal protein">
        <location>
            <begin position="1"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04012"/>
        </source>
    </evidence>
    <sequence length="662" mass="77235" checksum="95D555757B3A7F99" modified="1996-10-01" version="1">MHRASANSLLNSVSGSMMWRNQSSGRRPSKRLSDNEATLSTINSILGAEDMLSKNLLSYLPPNNEEIDMIYPSEQIMTFIEMLHGHKNFFKGQTIHNALRDSAVLKKQIAYGVAQALLNSVSIQQIHDEWKRHVRSFPFHNKKLSFQDYFSVWAHAIKQVILGDISNIINFILQSIDNSHYNRYVDWICTVGIVPFMRTTHTAPNLYNLLQQVSSKLIHDIVRHKQNIVTPVLLGLSSVIIPDFHNIKIFRDRNSEQISCFKNKKAIAFFTYSTPYVIRNRLMLTTPLAHLSPELKKHNSLRRHQKMCQLLNTFPIKVLTTAKTDVTNKKIMDMIEKEEKSSDAKKSLIKFLLNLSDSKSKIGIRDSVEGFIQEITPSIIDQNKLMLNRGQFRKRSAIDTGERDVRDLFKKQIIKCMEEQIQTQMDEIETLKTTNQMFERKIKDLHSLLETNNDCDRYNPNLDHDLENLSLSRALNIVQRLPFTSVSIDDTRSVANSFFSQYIPDTQYADKRIDQLWEMEYMRTFRLRKNVNNQGQEESITYSNYSIELLIVPFLRRFLNIYNLESIPEEFLFLSLGEILLAIYESSKIKHYLRLVYVRELNQISEVFNLTQTHPENSEPIFDSNIFSPNPENEILEKIKRIRNLRRIQHLTRPNYPKGDQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>P52460</accession>
    <name>CCU83_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Putative CC-type chemokine U83</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U83</name>
        <name type="synonym">EDRF3</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intercrine beta (chemokine CC) family. Highly divergent.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042976.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52460"/>
    <dbReference type="DNASU" id="1487963"/>
    <dbReference type="GeneID" id="1487963"/>
    <dbReference type="KEGG" id="vg:1487963"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035347">
        <property type="entry name" value="Putative_chemo_U83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17465">
        <property type="entry name" value="U83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0202">Cytokine</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000005246" description="Putative CC-type chemokine U83">
        <location>
            <begin status="unknown"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="97" mass="10410" checksum="414124E60E0E9EDD" modified="1996-10-01" version="1" precursor="true">MAIGFICSSPDAELFSEKSRMSSSVLLGCLLCCMDWSAAVPGKTEPFRKLFDAIMIKKLKSCSAAYPSDLDEGSMCDMADASPTSLELGLSKLDKES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>P52463</accession>
    <accession>Q69059</accession>
    <name>UL32_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Packaging protein UL32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U36</name>
        <name type="synonym">XIRF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Mainly cytoplasmic in transfected cell culture.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae UL32 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Was originally thought to be an envelope glycoprotein.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16743" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16743.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09330">
        <property type="entry name" value="T09330"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042929.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52463"/>
    <dbReference type="PRIDE" id="P52463"/>
    <dbReference type="DNASU" id="1487914"/>
    <dbReference type="GeneID" id="1487914"/>
    <dbReference type="KEGG" id="vg:1487914"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002597">
        <property type="entry name" value="Herpes_env"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01673">
        <property type="entry name" value="Herpes_env"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51988">
        <property type="entry name" value="HERPESVIRUS_UL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000116017" description="Packaging protein UL32">
        <location>
            <begin position="1"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Zinc finger 1" evidence="2">
        <location>
            <begin position="74"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Zinc finger 2" evidence="2">
        <location>
            <begin position="286"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="484" mass="56407" checksum="A4D43C75A3DEF4DA" modified="1996-10-01" version="1">MYKGWDSEALPIQSEILNEILLYCYLTPQPPIPSETTTATSPTNIENEISNLDNSENLEELKQLSVALNIDRRCNICSIVNLCLKQNKSWIYDYSLLCYKCNYAPKTPLSLLIVSTEFLMLIRERFPNINFDGLFLNNIVSIFDFHVHFFIHRCFANTVNDHIQSENITLNHMAIIRSTLLKEDTIPHIKIKKFLTKKMNPKKTQSSELNKKLTVPMKTRFTTLLFYMWSGTNVFDRVPFTDLTIRKHRFIKNLYSNKTDIELTAGPILLAQIPFSITKNKTTSVCLLCELMAASKQDYLFLKYLHQSIMDYCQNNLKMIDRVQFVIADIFEKTKIHTHVKNLSDYSKAIFDNEFSFSDDNFTLDTHVYLILRQTGTVGVYKHFFCDPLCLANCKTINPEVLFNTTDAGEIQDLKVTICYRNEYLSIVEKHVWLAIHLFKAFQIIKPNHKNKTQITEFLKDFTNLLALHHFDIVDPIFTVNYYV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>P52465</accession>
    <name>NEC2_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear egress protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NEC2</name>
        <name type="ordered locus">U34</name>
        <name type="ordered locus">XILF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterohexameric complex with NEC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes also at the transient membrane of perinuclear virions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae NEC2 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042927.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52465"/>
    <dbReference type="PRIDE" id="P52465"/>
    <dbReference type="DNASU" id="1487911"/>
    <dbReference type="GeneID" id="1487911"/>
    <dbReference type="KEGG" id="vg:1487911"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04024">
        <property type="entry name" value="HSV_NEC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007626">
        <property type="entry name" value="Herpesvirus_viron_egress-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04541">
        <property type="entry name" value="Herpes_U34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0426">Late protein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000116029" description="Nuclear egress protein 2">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="topological domain" description="Nuclear" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04024"/>
        </source>
    </evidence>
    <sequence length="276" mass="31671" checksum="5C5ED509CF9CE937" modified="1996-10-01" version="1">MANVLKEKMYDELLSATCRILKLGSHDYRITERNLLSKNPKFPLCDIILKLDYAYNLEYLLSLWEHVTKQEPRFVFKNTGGAVSMSCYLHAPVKVEGHHAVRECNILRVNECLTVRMSDIVAMKPSTFAVFTKCIIRRNRDDTYVVEFVAFGPENESEYISLLKAIFLKKCSMGKQHLESNRFCQGLRRRSSHVLEKGRFESSGKVVNKASAVVTSQESIKQFYEKEKSLLSGVKFWRLSERHCRFALVGICFLLALYFCYVLLKKTPTPASGSVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>P52467</accession>
    <name>PRIM_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase</fullName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U43</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the helicase and the primase-associated factor to form the helicase-primase factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Requires the presence of the primase associated factor to properly localize in the host cell nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae DNA primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X92436">
        <property type="protein sequence ID" value="CAA63169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042936.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52467"/>
    <dbReference type="DNASU" id="1487921"/>
    <dbReference type="GeneID" id="1487921"/>
    <dbReference type="KEGG" id="vg:1487921"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04011">
        <property type="entry name" value="HSV_PRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033685">
        <property type="entry name" value="HSV_PRIM"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000116108" description="DNA primase">
        <location>
            <begin position="1"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="1">
        <location>
            <begin position="804"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="site" description="Essential for primase activity" evidence="1">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="site" description="Essential for primase activity" evidence="1">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04011"/>
        </source>
    </evidence>
    <sequence length="860" mass="100080" checksum="660E8AE30B4674F6" modified="1996-10-01" version="1">MTIVVFATEYDAANVIFSILCRSPSEHLIFPIIVKYKPSNNVSFCLQTQKCKNSKRIDTVFVCHAEKLNLSHYIQTASPIKAEDVANSLNDKETESLYVDMILSQTGKEREDVEFKYMAYFHKSLIIKYLTGKFLLPTSPFWFLSTYGQTEGMLLLTMFYYLFEEQKSTITTTKNYVQCFTENTGNMVFTYSSMSEFINITLKSKFRKLFADFSTYARQKNLRDKEEFKHLDTQINLFRKSSHLTNTFRVHYIYIAYNTALETTKFVNYCNLTSYDSNLPIGQQCQRNLHILGNSLHENLLCIMKQYFNADCYFKTYIDIKRLKNPNLNVTEYEYALVSKKKTIQALTSEQITRAIAKCNKNGEGLFSPVKPGLQGLLEISASDRYVQIQDKRIYRRQHLHKDYHRPFPVFRVQLLHKNIFCFGNSEDWYENMGFNRILQYLPDEYISDEALTRAIWLQDTHFLCDDVEKQFYTTRHEIFNERIPVTNYIGDLDLPLQDTATITEETFFSMCRLIRLTLINAWKKIFPSIDTDTHPIFFFKTQCDTTNDTLDYTEDPTEIKQFCVCRKKIGLRISIPLPNGTAIAGGEPLKQLSKILNHVMCLDQELSQILNSITFPGECFDIGIYHTGHCIRIGYMYKTDMDKGKMLHGRLTPIFIVPEGYRNSCKTFIQMQMDLNNLLHHGTKKAPIEELIYNITDKGCPKENLSFMDLKSRQLWNKVNIATETLITKYLNTHGFNNNATSADDSLLSFIRLIGWPIIKTQLITHYETRIAQQFSQVTFIKIDSKNLQIKKTQFGRVSDFSCLNRQHRGNRDNVLVYIQLKADGNRLILILWSTCFATKCQSNSKQVHCSIALEQLKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>P52469</accession>
    <name>UL79_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U52</name>
        <name type="synonym">XKLF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae UL79 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042945.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52469"/>
    <dbReference type="DNASU" id="1487932"/>
    <dbReference type="GeneID" id="1487932"/>
    <dbReference type="KEGG" id="vg:1487932"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004290">
        <property type="entry name" value="Herpes_UL79"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03049">
        <property type="entry name" value="Herpes_UL79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116222" description="Protein U52">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="258" mass="30030" checksum="7F102B088E459FF2" modified="1996-10-01" version="1">MTQIGQYIKLNDAVPNLILHITTKLLRNENLTSFKQEELLLIQHVCTSMLSHGIKILLLRESLYNSGIGDIVILNRKISNNYWFRIFSILKQHSDAELLRHMFNESHSAYISKKLHYSGNVSHMINFLFMDEFGVNLKIPEELICEGNIVFSVGAIYNHRLLKICRFFNRFWGDQEREPTVRLICKHLWFAYLIMFGKFEISTLAYSQQRAEHKAGLFSFLQNDFKVFCGMSENPQLLDSSAIFDLTGISAEDLFSYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-02-23" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>P52473</accession>
    <name>TEG7_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Tegument protein UL51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U44</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays several roles during the time course of infection, including egress of virus particles from the perinuclear space and secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Oligomerizes. Interacts with U75; this interaction mediates U75 incorporation to virions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Palmitoylation is necessary for Golgi localization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae UL51 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X92436">
        <property type="protein sequence ID" value="CAA63170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042937.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52473"/>
    <dbReference type="DNASU" id="1487922"/>
    <dbReference type="GeneID" id="1487922"/>
    <dbReference type="KEGG" id="vg:1487922"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007619">
        <property type="entry name" value="Herpes_U44"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04533">
        <property type="entry name" value="Herpes_U44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1040">Host Golgi apparatus</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-0920">Virion tegument</keyword>
    <feature type="chain" id="PRO_0000116209" description="Tegument protein UL51 homolog">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine; by host" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P10235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P16823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="213" mass="24296" checksum="6450CD865A786FD7" modified="1996-10-01" version="1">MSLGYWGVMGNCFRRLSLFGQPTQAKYEMLCSSDDLETEELTFFLDMTYKDFGVYQNDIISHQKDTETMKTLLGLLPMYKKTKLRHTVMERCLSNCPNHVKDALCVELMKAEKILQTMDVVFMKTLIGEFSMCTENLNQLLNKFATDQSTLSDVEKINSLIEIDGENSKRLLVELDPILHEETGLYQALPNVVTEAPSEKVKSIRVESEGESV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>P52527</accession>
    <name>VU25_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U25</name>
        <name type="synonym">EPLF3</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae US22 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042918.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52527"/>
    <dbReference type="DNASU" id="1487903"/>
    <dbReference type="GeneID" id="1487903"/>
    <dbReference type="KEGG" id="vg:1487903"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003360">
        <property type="entry name" value="US22-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02393">
        <property type="entry name" value="US22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116321" description="Protein U25">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="316" mass="37096" checksum="3A0FAA7CD11E2D60" modified="1996-10-01" version="1">MGLSSSKDIDLLVNFIENRQGATLALPWPEDYRLTLHSVENIPEISREDVQNWAKTYMCCGGELVVVGVIHKAKTRTCRGPIVLQGARGHIYVYNGFFDRSLYHVASSFHDLFSNGLRFFYPIYETCDYALDSTVALDMIAHSKSFSELLHYRNERKNAFFTLKTYPYKTFVRFCNLSMTEFSSRHLIQWRRKLQTSLLDVVFIVQHNFFGDWRELVVVFDGHGMLFCVDREESLLFIARNMSDFLKIGCLRYNENRRLHTQWFTQDTDYIKQVDEMFSRDVLCPLREHCQRSRRERGLLKICTSLVRGVNCIERG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>P52529</accession>
    <accession>Q69469</accession>
    <accession>Q69563</accession>
    <accession>Q76QS7</accession>
    <name>U79_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U79/U80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U79/U80</name>
        <name type="synonym">EDRF1/EDRF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P52529-1</id>
            <name>1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P52529-2</id>
            <name>2</name>
            <sequence type="described" ref="VSP_034765 VSP_034766"/>
        </isoform>
        <text>The isoforms have been deduced by homology to HHV-6B.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae U79/UL112 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAA68470" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAA68471" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58329" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58371" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68470.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68471.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58329.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58371.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042972.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52529"/>
    <dbReference type="PRIDE" id="P52529"/>
    <dbReference type="DNASU" id="1487960"/>
    <dbReference type="GeneID" id="1487960"/>
    <dbReference type="KEGG" id="vg:1487960"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004138">
        <property type="entry name" value="U79_P34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03064">
        <property type="entry name" value="U79_P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0025">Alternative splicing</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116325" description="Protein U79/U80">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="splice variant" id="VSP_034765" description="In isoform 2." evidence="3">
        <original>ALPPCISI</original>
        <variation>DEPRRSIQ</variation>
        <location>
            <begin position="251"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="splice variant" id="VSP_034766" description="In isoform 2." evidence="3">
        <location>
            <begin position="259"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="474" mass="54205" checksum="077D95DC04E448E9" modified="2008-07-22" version="2">MYAEERAYGSFDDVMEVYQQIVTESIQLKRLHFGSGCLIEFLGDSGTCETFCGGWISMICWTSDTNSMGSLTVDIGIDDGKYKTYNARGFLLCSKSITSISQNTEGRDRILTVSQENNKLQITFVTLTKVFKEHDIRNLGDPKCIEKFEKECRALDRKKHDDEHRKRSGKQKEKRKVEDTDKKKDDDRRKQEERKRNDEDKQPDKKEESDELPKEKRQKYHDMKRNLEEQSHEDGITLTSTTLVNGAVEGALPPCISIDNHEDQQHDELDKRAYAQGTNREGLSNEDNYGNFRLNKSLEQLRAKLVASSGDIVERSLLKLKECLDNVKDNLIKNECADVTGPSKCLSKTKHIEPKKQIVFSDCVRPVPVCEIKPFIDVRLFETARSPRRLRQRTRTIVGSTDGAIEQQRVISGQNRGRARGRGRGRAPRRRNSNINNSRTQTTIVIDDSSEAENFENEGSFNEDLLATTILETL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>P52532</accession>
    <name>VU84_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U84</name>
        <name type="synonym">EDLF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae U84 family.</text>
    </comment>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042977.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52532"/>
    <dbReference type="DNASU" id="1487964"/>
    <dbReference type="GeneID" id="1487964"/>
    <dbReference type="KEGG" id="vg:1487964"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005028">
        <property type="entry name" value="Herpes_IE2_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03361">
        <property type="entry name" value="Herpes_IE2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116329" description="Protein U84">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="342" mass="39556" checksum="2AF4C6BDEC729C74" modified="1996-10-01" version="1">MKDRGNKNTSKTRQTVKSRRTRKTTKQFVERKKNLSAKTTIRNNRLQNNLSPQTTPTEKPVDYATARVFPQHTPYDIKFNKEKYRNNEIYAYSKLRKISNAVFRQEKEINRLTVFTDKPLADLSFKMPVNTSTTEKKEIVRSTECQRQDRNTVNAFKIFQSYETSPPYSPCSPKNFMSEIYRLFRCYNASIVQIQVYSRNKILINAMQEKLMSIGNMVINVGEQIISESVHHEPVVAIAINQFFRGTVPQTDALRKNAVTPIPVNASKKKLVGICSLMINAPTEKDLLCAAHVCINFAICYPNEITLNIAKLTQPMLLQEHITIYNSFNKYIYWDDYGKLLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-11-09" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>P68324</accession>
    <accession>P30001</accession>
    <name>GH_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Envelope glycoprotein H</fullName>
            <shortName evidence="1">gH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gH</name>
        <name type="synonym">BHLF1</name>
        <name type="synonym">U48</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carss A.L."/>
                <person name="Sun N."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1333836"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="613" last="622">
            <title>Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carrigan D.R."/>
                <person name="Carss A.L."/>
                <person name="Arno J."/>
            </authorList>
            <dbReference type="PubMed" id="8385692"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="1847" last="1857">
            <title>Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein.</title>
            <authorList>
                <person name="Liu D.X."/>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lelliott C."/>
            </authorList>
            <dbReference type="PubMed" id="8397282"/>
        </citation>
        <scope>INTERACTION WITH GLYCOPROTEIN L</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host endosome membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">N-glycosylated, O-glycosylated, and sialylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae glycoprotein H family.</text>
    </comment>
    <dbReference type="EMBL" id="X64320">
        <property type="protein sequence ID" value="CAA45603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A40511">
        <property type="entry name" value="VGBEH6"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042941.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P68324"/>
    <dbReference type="PRIDE" id="P68324"/>
    <dbReference type="DNASU" id="1487928"/>
    <dbReference type="GeneID" id="1487928"/>
    <dbReference type="KEGG" id="vg:1487928"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044175">
        <property type="term" value="C:host cell endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019064">
        <property type="term" value="P:fusion of virus membrane with host plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04033">
        <property type="entry name" value="HSV_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003493">
        <property type="entry name" value="Herpes_gH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035305">
        <property type="entry name" value="Herpes_glycoH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038172">
        <property type="entry name" value="Herpes_glycoH_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17488">
        <property type="entry name" value="Herpes_glycoH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1169">Fusion of virus membrane with host cell membrane</keyword>
    <keyword id="KW-1168">Fusion of virus membrane with host membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1032">Host cell membrane</keyword>
    <keyword id="KW-1039">Host endosome</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0730">Sialic acid</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0261">Viral envelope protein</keyword>
    <keyword id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-1160">Virus entry into host cell</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000436659" description="Envelope glycoprotein H" evidence="1">
        <location>
            <begin position="17"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="topological domain" description="Virion surface" evidence="1">
        <location>
            <begin position="17"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="1">
        <location>
            <begin position="693"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with gL" evidence="1">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04033"/>
        </source>
    </evidence>
    <sequence length="694" mass="79555" checksum="653ADDA102E7386D" modified="2004-11-09" version="1" precursor="true">MLLRLWVFVLLTPCYGWRPLNISNSSHCRNGNFENPIVRPGFITFNFYTKNDTRIYQVPKCLLGSDITYHLFDAINTTESLTNYEKRVTRFYEPPMNDILRLSPVPSVKQFNLDRSIQPQVVYSLNMYPSQGIYYVRVVEVRQMQYDNVSCKLPNSLKELIFPVQVRCAKITRYVGEDIYTHFFTPDFMILYIQNPAGDLTMMYGNTTSINFKAPYKKSSFIFKQTLTDDLLLIVEKDVIDVQYRFISDATFVDETLNDVDEVEALLLKFNNLGIQTLLRGDCKKPNYAGIPQMMFLYGIVHFSYSTKNTGPMPVLRVLKTHENLLSIDSFVNRCVNVSEGTLQYPKMKEFLKYEPSDYSYITKNKSISVSTLLTYLATAYESNVTISKYKWTDIANTLQNIYEKHMFFTNLTFSDRETLFMLAEIANIIPTDERMQRHMQLLIGNLCNPVEIVSWARMLTADRAPNLENIYSPCASPVRRDVTNSFLKTVLTYASLDRYRSDMMEMLSVYRPPNMERVAAIQCLSPSEPAASLTLPNVTFVISPSYVIKGVSLTITTTIVATSIIITAIPLNSTCVSTNYKYAGQDLLVLRNISSQTCEFCQSVVMEYDDIDGPLQYIYIKNIDELKTLTDPNNNLLVPNTRTHYLLLAKNGSVFEMSEVGIDIDQVSIILVIIYILIAIIALFGLYRLIRLC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q00683</accession>
    <name>VU94_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U94</name>
        <name type="synonym">HCLF2</name>
        <name type="synonym">REP</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1991" name="Nature" volume="351" first="78" last="80">
            <title>Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Efstathiou S."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1851252"/>
            <dbReference type="DOI" id="10.1038/351078a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1649" last="1660">
            <title>The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1321205"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X59532">
        <property type="protein sequence ID" value="CAA42112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="D11134">
        <property type="protein sequence ID" value="BAA01906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1630">
        <property type="entry name" value="JQ1630"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042987.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q00683"/>
    <dbReference type="PRIDE" id="Q00683"/>
    <dbReference type="DNASU" id="1487970"/>
    <dbReference type="GeneID" id="1487970"/>
    <dbReference type="KEGG" id="vg:1487970"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001257">
        <property type="entry name" value="Parvovirus_NS1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014835">
        <property type="entry name" value="Rep_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01057">
        <property type="entry name" value="Parvo_NS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08724">
        <property type="entry name" value="Rep_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116299" description="Protein U94">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <sequence length="490" mass="55848" checksum="221CE58165187C1F" modified="1993-04-01" version="1">MFSIINPSDDFWTKDKYIMLTIKGPMEWEAEIPGISTDFFCKFSNVSVPHFRDMHSPGAPDIKWITACTKMIDVILNYWNNKTAVPTPAKWYAQAENKAGRPSLILLIALDGIPSATIGKHTTEIRGVLIKDFFDGNAPKIDDWCTYAKTKKNGGGTQVFSLSYIPFALLQIIRPQFQWAWTNINELGDVCDEIHRKHIISHFNKKPNVKLMLFPKDGINGISLKSKFLGTIEWLSDLGIVTEDAWIRRDIRSYMQLLTLTHGDVLIHRALSIAKKRIRATRKAIDFIAHIDTDFQIYENPVYQLFCLQSFDPILAGTILYQWLSHRGGKKNTVSFIGPPGCGKSMLTGAILENIPLHGILHGSLNTKNLRAYGQVLVLWWKDISINFDNFNIIKSLLGGQKIIFPINENDHVQIGPCPIIATSCVDIRSMVHSNLHKINLSQRVYNFTFDKVIPRNFPVIQKDDINQFLFWARNRSINCFIDYTVPKIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2021-06-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q00701</accession>
    <name>P100_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Large structural phosphoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>100 kDa phosphoprotein</fullName>
            <shortName>pp100</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Major antigenic structural protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">U11</name>
        <name type="synonym">P1LF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Virol." volume="66" first="3918" last="3924">
            <title>Gene for the major antigenic structural protein (p100) of human herpesvirus 6.</title>
            <authorList>
                <person name="Neipel F."/>
                <person name="Ellinger K."/>
                <person name="Fleckenstein B."/>
            </authorList>
            <dbReference type="PubMed" id="1374813"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Virion tegument</location>
        </subcellularLocation>
        <text evidence="1">Also found in dense bodies.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated at multiple sites.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae large structural phosphoprotein family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16716" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="M87287">
        <property type="protein sequence ID" value="AAA46012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16716.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09303">
        <property type="entry name" value="XPBE12"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042902.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q00701"/>
    <dbReference type="PRIDE" id="Q00701"/>
    <dbReference type="DNASU" id="1487891"/>
    <dbReference type="GeneID" id="1487891"/>
    <dbReference type="KEGG" id="vg:1487891"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010340">
        <property type="entry name" value="Herpes_UL11/UL32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06070">
        <property type="entry name" value="Herpes_UL32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-0920">Virion tegument</keyword>
    <feature type="chain" id="PRO_0000116300" description="Large structural phosphoprotein">
        <location>
            <begin position="1"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="870" mass="97072" checksum="F25954DEA19BF824" modified="1993-04-01" version="1">MDLQRHPIPFAWLDRDKVERLTDFLSNLERLDNVDLREHPHVTNSCVVREGDDVDDLKTLYNLLVLWLMYHYVLSKRKPDYNAIWQDITKLQSVVNEYLNSKGLNKGIFENMFTNKEKFESQFSDINRALLRLGNFIKWGSNVAIDTPYVNLTAEDSSEIENNLQDAEKNMLWYTVYNINDPWDENGYLITSINKLIYLGKLFLALTQSWSKLEKVAMSQIVITQNHLSGHLRRHDNFNIVYSHRVLQTPLTGQRVESFLKIITSDYDIIKSSLESHSASKAFSMSEIGPNSLMDFVPLRGDIHSNLTLPSMSIDTKKSSLDPARLKKSNSRSLDSFLRMQRQPKFLELDSVDNAGEKILLKEATLGGENVKATTPASSVSLMSGVESPSSFTSTNLDLPLSSFTSTNLDLRDKSHGNYKIGPSGILDFNVKFPPNAQLNTNGVDLLQDKTSIGSPSSGITDVVNGFANLNLHQNKSNVSPPWSRNTAANADFLDPVHRFVPEQTGTPFVLNNSDVAGSEAKHTTYSTETGVSPRNVFLIKDLRGKDGFRKQKQSDIPKSLTKERNDKAIMHSREVTGDSGDATETVGARNSPALRKIKQANDFFAGLNKKNDRDVLRGGKGNSKDLHSGGNAKKKEMSGKFNDDKEMTRNGQEPSRSLMGDARNAGDEQYIQAGLGQRVNNLLSQFTNLISLGEKGIEDILQNQRGTELKLATENKSGRESEEANVEKILEVSNPQDMFKNFRLQNDLDSVQSPFRLPDADLSRELDSASFKDALDLKLPGNGEREIDLALEKVKVGETETSDLKVGQDESFVPAQLMKVETPEEKDDIIEQMVLRIRQDGETDENTVSGPGVAESLDIEAKGESAIAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q01346</accession>
    <name>VU8_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U8</name>
        <name type="synonym">SFL1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae US22 family.</text>
    </comment>
    <dbReference type="EMBL" id="D10082">
        <property type="protein sequence ID" value="BAA00980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1652">
        <property type="entry name" value="JQ1652"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q01346"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116315" description="Protein U8">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="356" mass="41102" checksum="91E32BF9EED9A382" modified="1994-06-01" version="1">MDLEAKEISGNIPNENALAELCRLCESADLSQIENFVGRYKNWCLSIIWPRNCWLRFTPRKDVAGYTEKMFEDMDDHYQGFVEKLCLLGTIQIPYRDVPILIGRSKRIFLHDLETDTLHFVCDNFEQFVRYGVLGTNIITCAEPVYRHGLYEGPRFESLENLMNNDVLRSPYTLNVHVKLNRKGVLGIKAMRKHYIAMLREFDELARCASLDDVGRFVSLNVGRDLRLDMPVFKSLTLGTRDSVWTGTCRLANLKEQEDLVEKVVVLGYLNDHDYESKCTRPILCIGKSGKIYYYDWIDNVLVKLGDCLLTFLRVGFARLFADYGYEKIGKISMRFGRMSTLGMSETYQSCMSLSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2022-02-23" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q01347</accession>
    <name>VU9_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U9</name>
        <name type="synonym">SFL2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="D10082">
        <property type="protein sequence ID" value="BAA00981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1653">
        <property type="entry name" value="JQ1653"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q01347"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116318" description="Protein U9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <sequence length="104" mass="11818" checksum="E78A38F1798A2653" modified="1994-06-01" version="1">MAVRKLWKTVVQLFSKSKSEECNTEAGTMEVSFLKYGVRGLNADCSYVKSQCIKLSECECLYTFASDVCKEDFHNSEEMKVFVVQHSQEMVDGTDLFVHAEESV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q01348</accession>
    <name>VU10_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>U10 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U10</name>
        <name type="synonym">P1RF0</name>
        <name type="synonym">SFR1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-407</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae U10 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="D10082">
        <property type="protein sequence ID" value="BAA20953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042901.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q01348"/>
    <dbReference type="DNASU" id="1487889"/>
    <dbReference type="GeneID" id="1487889"/>
    <dbReference type="KEGG" id="vg:1487889"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007578">
        <property type="entry name" value="Herpes_U10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04489">
        <property type="entry name" value="DUF570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116319" description="U10 protein">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="436" mass="50122" checksum="6ADCA71AC9ECE87E" modified="1996-10-01" version="2">MEIVTYKTVSARSPTVTWSSGFGRAIASIQKRNQDNIRKPLRFYTGLLHCLIKQYEHCLVPPNKSIRFDKGKIEVAALILDLGHQVLGRQIHVRQRIYSWTSITLPKLFTPKELYFLIASPEEENIAFNPTITKGGWISGSFSYPVDYRSNFSLTGMSANILMVPFVPYKYPLNYARFISSIDLMILNEQFPEHECGDIQILKQRNYLYLGVIKNLTWKKSVTGTGQTAPHRILKASFIGSWPDTSLPDRVALRFFNNTRFTIHCHEFSINIENLGLVKNKEKVFGTLATVCCEQIPSLLTTENLPKYLIVQFEVVTQIEEPEPLLFSSNPKLYFTGDVLNATIQLQHNPNYYELLVHAPYDIHFYPSRCHIVILPIRYFTKPDKQILISGYQNEGFFETQVMLWAPGTPLHITLRSFSPNLILPQSTKRRNRKAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q01349</accession>
    <name>VU1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U1</name>
        <name type="synonym">SHL1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-357</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae US22 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="D10082">
        <property type="protein sequence ID" value="BAA00976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1647">
        <property type="entry name" value="JQ1647"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042893.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q01349"/>
    <dbReference type="PRIDE" id="Q01349"/>
    <dbReference type="DNASU" id="1487881"/>
    <dbReference type="GeneID" id="1487881"/>
    <dbReference type="KEGG" id="vg:1487881"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116303" description="Protein U1">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="366" mass="39814" checksum="43FA410E8AFA2624" modified="1996-10-01" version="2">MFCGSPFLGISSWSLASAALCPPSCSFSAGRDLRCDAEVPEVKWTAFVRTLVTRPLSADDVWDFVSTFAHCRLALSWPVGAELRFATSDMLGITQAEVAKLSRRYGCCPGMDLTVIGVTIFAEVSALVLVGECGEIYAFNGVFDDALYRLAEDAFGLWKHGLRRFEPVYGSKCLTETGASFFGGMSGVDDVLAFAVSFDKALVPLPWPRGAFFEFAVPGRPEKRWRLIPGGGVAVVIGRFFGRGVTSPLLRRQRVLMDQVGRVYAASLDGGAVVRLSDSFRAFLAMGVRKLFKNHRFPPGHLWTMQLPVTCVHAPVIDLPAVYQLSPHMVERGMPVASCEASTVVRGDCEETETEESTSGDSVLVC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q01351</accession>
    <name>VU4_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U4</name>
        <name type="synonym">SHL3</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae U4 family.</text>
    </comment>
    <dbReference type="EMBL" id="D10082">
        <property type="protein sequence ID" value="BAA00978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1649">
        <property type="entry name" value="JQ1649"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042895.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q01351"/>
    <dbReference type="DNASU" id="1487885"/>
    <dbReference type="GeneID" id="1487885"/>
    <dbReference type="KEGG" id="vg:1487885"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116308" description="Protein U4">
        <location>
            <begin position="1"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="535" mass="61961" checksum="1AF9D1D5272F4000" modified="1994-06-01" version="1">MELLDHDIYKGPVRERVTYTIPNHPYLSLTVHHSRELDVDLKDITEEMIIDSGTLTAEDLFMTRGLRFCDDSVLWAALAEKVSVEFQRRGKTTMDLSAFMSLLERLTFEDETSVFYRLLTKCTALAHFSILEYIVDGEKRDTISAHFNRLLELLDSLFLQFLMLRNRSESNTLLTLFDILPNPKEIYGDAASPTSVLLKHFLSDHIFVAYASSYRFVSSVLCSCDQCRASLFRIYLGKKDSRAVHISDISEFDPADLILGQLHLDAREAVALRAEIDRDLGSSLILNSMERRHLPILHDKQLGRGHFERNILKVYCNIVLCLFLLRRVKQRIVSDLTAIARFFVKAISEMERCIDTVSGLRGVRIKLLVVSSQFEIKDPMRVPRLCFFFLEIVAILVSGYDKERHRVRALLEHLCLKKICLGDLCASMRLAREIRHDVLEGFLNTLELSYMSNPVRFFRFHDCNLYGTHMWSGVYPNVVPYAVRGGGSFDIRLQEHRRRQKRIVVRRRLIRRVQQRGLDIREARRVPKPACVTFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2020-08-12" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q01352</accession>
    <name>VU5_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U5</name>
        <name type="synonym">SSL1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae U4 family.</text>
    </comment>
    <dbReference type="EMBL" id="D10082">
        <property type="protein sequence ID" value="BAA32340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1650">
        <property type="entry name" value="JQ1650"/>
    </dbReference>
    <dbReference type="SMR" id="Q01352"/>
    <dbReference type="PRIDE" id="Q01352"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010302">
        <property type="entry name" value="U5-like_protein_herpesevirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05999">
        <property type="entry name" value="Herpes_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116310" description="Protein U5">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="444" mass="51586" checksum="D94F16B44D938EB4" modified="1996-10-01" version="2">MVKDLKFMDNFNEKWQCITKLAFLGLYAGASLFNFTSKPTLGYWCRYLSEYASMLLFQFESKLKELTKESTRQLGGYNLCHWGQELKDCLENKSDVFFRYDFFERIESCLIEHFMLLCGCVECRRMFIMYNKRGRKFDFGHSVRIQCFPMIGSIRLPAFLHLGEPYDVSLSSLIAKDLGLSMIEGQIELSRLPISLQISVTPDKKALLTFLTNIVFIVFVVNTLYRVINAELDIYYDLFTEEVGKLCVAMEEEMKLGRNGCLGDLCYFSPMKQMKEIVRCPGEKSQFILKCWEALRIGFSVPAYKDYDETPFMEMFFMHHLHIKRFHEDNDRDLVSCDNLIPGFFIVNTDGENFLQRLQRVVLPVVEDYLTNTRCINGTMAFFFSGLKYFGSGNHRGFQISPEKDVRAIAYKLGSLDVLRDDYKYYEYTPPDCPGELNGHGGDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q01353</accession>
    <name>VU7_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U7</name>
        <name type="synonym">SSL2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae US22 family.</text>
    </comment>
    <dbReference type="EMBL" id="D10082">
        <property type="protein sequence ID" value="BAA00979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1651">
        <property type="entry name" value="JQ1651"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042898.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q01353"/>
    <dbReference type="GeneID" id="1487887"/>
    <dbReference type="KEGG" id="vg:1487887"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116313" description="Protein U7">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="342" mass="39356" checksum="1471AE63FB0F779E" modified="1994-06-01" version="1">MFQTEIVPVCNDEFALSSCVPTLDFDVDVLSAAYGDGLEISSPGLRCCIAWPPMYALTLGEFYHFHTHRWVSAYDWSSLLDADEFMSAVGYAHPIYRDPNPDYDPYVMHTSTGKTIAVDTVTEKVYIIAESLVQFFNIGLRQFPPFAEAELDPEQEKMWFGETKCGREEFILLQRNLPAMKDYVAKHSGKRIRVDAFQDFDFSFCSLSDIYYLTGPGILEKITEKDYAIIGTCARSQAEPNCRAAIVMGSNCHIYIYVENKISKVSKSLRTFIRRGFDELLYKEKYSLDWSDDTLFYISDTETENLNRMLNGELPVLRSKPRHMCVRKDRWVDVFCVVFQRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q04630</accession>
    <name>GM_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Envelope glycoprotein M</fullName>
            <shortName evidence="1">gM</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gM</name>
        <name type="ORF">18L</name>
        <name type="ORF">U72</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="J. Gen. Virol." volume="76" first="147" last="152">
            <title>Human herpesvirus 6 (strain U1102) encodes homologues of the conserved herpesvirus glycoprotein gM and the alphaherpesvirus origin-binding protein.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Nicholas J."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="7844524"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus</location>
            <location evidence="1">Host trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae glycoprotein M family.</text>
    </comment>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042965.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="DNASU" id="1487953"/>
    <dbReference type="GeneID" id="1487953"/>
    <dbReference type="KEGG" id="vg:1487953"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044175">
        <property type="term" value="C:host cell endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044178">
        <property type="term" value="C:host cell Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044201">
        <property type="term" value="C:host cell nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04035">
        <property type="entry name" value="HSV_GM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000785">
        <property type="entry name" value="Herpes_glycop_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01528">
        <property type="entry name" value="Herpes_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00333">
        <property type="entry name" value="HSVINTEGRLMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1039">Host endosome</keyword>
    <keyword id="KW-1040">Host Golgi apparatus</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0261">Viral envelope protein</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000115779" description="Envelope glycoprotein M">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="topological domain" description="Virion surface" evidence="1">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="topological domain" description="Virion surface" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="topological domain" description="Virion surface" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="1">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="topological domain" description="Virion surface" evidence="1">
        <location>
            <begin position="285"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="1">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with gN)" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04035"/>
        </source>
    </evidence>
    <sequence length="344" mass="38992" checksum="7EF1394AF4A12254" modified="1996-10-01" version="1">MASSRVDTINLRIWLVSIICAALSFINVTVYLIAINFPNLGFPCAYFEINDLKAVNLSANNQIYQMTHQLYINPVQIICYVLIMAMLFLLIIIYYIVCCAKVFSSNKTSNVNQTTRDITWMGDTSSCFQFILIMDTFQLFVTALSFRLVALGAFAYCIFFVCFTTFNVTLITQFQSADKSFFAFQKIHPNLKGTVQFKTVVINLTELMLGYSTMFLGITTCLGVGNSIYIRSITVAYSSINTFLVMACIYSIVIEAVLVRYVKPLFGYYVGMFCGAVGLSFPILQYETFFESEWSTGLIINLAVIAIISIGFIICRLVRYLVKKKRRYKQLVNTESSSLMDENE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-02-23" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q06092</accession>
    <name>UL24_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein UL24 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U49</name>
        <name type="synonym">BHRF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carss A.L."/>
                <person name="Sun N."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1333836"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
            <location evidence="1">Host nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text>Expressed late in the infection cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae UL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="X64320">
        <property type="protein sequence ID" value="CAA45604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E56653">
        <property type="entry name" value="E56653"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042942.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q06092"/>
    <dbReference type="DNASU" id="1487929"/>
    <dbReference type="GeneID" id="1487929"/>
    <dbReference type="KEGG" id="vg:1487929"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002580">
        <property type="entry name" value="Herpes_UL24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01646">
        <property type="entry name" value="Herpes_UL24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1040">Host Golgi apparatus</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0426">Late protein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000115985" description="Protein UL24 homolog">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="252" mass="29292" checksum="5827B992FBC0C927" modified="1996-10-01" version="1">MSLTGLPDIRKKIGQFHHLRIYKQILSLQGNFARLNYFLGDVFPANLRSASVSVFFEVRLGPRIPDCIVLLKSVDAKDEFAFHCYFFEFKTTLGKSTMQSVHHNCIHQAQYLQGLRQLQQSISFLDQYLIADEVSWNVVPVICFFRQWGLKLDFFKKFSGKTKRLSFSFIRDLFARSQDGAVQSLLSIPNYTNFRRACQKHTDLYRKRCRKAPKSVLTKTSGENRSRASRQVAKNAPKNRIRRTAKKDAKRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-02-23" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q06093</accession>
    <name>GO_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>120 kDa Glycoprotein O</fullName>
            <shortName>gO-120K</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Glycoprotein U47</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName>80 kDa Glycoprotein O</fullName>
                <shortName>gO-80K</shortName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name type="primary">U47</name>
        <name type="synonym">BHLF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carss A.L."/>
                <person name="Sun N."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1333836"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <molecule>80 kDa Glycoprotein O</molecule>
        <text evidence="1">Part of a gH-gL-gO complex.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>80 kDa Glycoprotein O</molecule>
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cell membrane</location>
        </subcellularLocation>
        <text evidence="1">Expressed on the host cell surface as a part of the gH-gL-gO complex.</text>
    </comment>
    <comment type="PTM">
        <molecule>120 kDa Glycoprotein O</molecule>
        <text evidence="1">A shorter mature protein, gO-80K, is produced probably by proteolytic cleavage.</text>
    </comment>
    <comment type="PTM">
        <molecule>120 kDa Glycoprotein O</molecule>
        <text evidence="1">Modified with high mannose-oligosaccharides.</text>
    </comment>
    <comment type="PTM">
        <molecule>80 kDa Glycoprotein O</molecule>
        <text evidence="1">N-glycosylated with complex glycans.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the herpesviridae U47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">It is uncertain whether Met-1 or Met-34 is the initiator.</text>
    </comment>
    <dbReference type="EMBL" id="X64320">
        <property type="protein sequence ID" value="CAA45602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C56653">
        <property type="entry name" value="C56653"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042940.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="IntAct" id="Q06093">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MINT" id="Q06093"/>
    <dbReference type="PRIDE" id="Q06093"/>
    <dbReference type="DNASU" id="1487926"/>
    <dbReference type="GeneID" id="1487926"/>
    <dbReference type="KEGG" id="vg:1487926"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008645">
        <property type="entry name" value="Roseolovirus_U47"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05467">
        <property type="entry name" value="Herpes_U47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1032">Host cell membrane</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000038316" description="120 kDa Glycoprotein O">
        <location>
            <begin position="57"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000445358" description="80 kDa Glycoprotein O">
        <location>
            <begin position="57"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P30005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="651" mass="73250" checksum="A46043E2DFD47423" modified="1996-10-01" version="1" precursor="true">MHLEVIVQSYKKSKYYFSHTFYLYKFIVVNSPDMLHISRLGLFLGLFAIVMHSVNLIKYTSDPLEAFKTVNRHNWSDEQREHFYDLRNLYTSFCQTNLSLDCFTQILTNVFSWDIRDSQCKSAVSLSPLQNLPRTEIKIVLSSTTANKSIIASSFSLFYLLFATLSTYTADPPCVELLPFKILGAQLFDIKLTEESLRMAMSKFSNSNLTRSLTSFTSKNFFNYTSFVYFLLYNTTSCVPSNDQYFKQSPKPINVTTSFGRAIVNFDSILTTTPSSTSASLTSPHIPSTNIPTPAPPPVTKNSTKLHTDTIKVTPNTPTITTQTTESIKKIVKRSDFPRPMYTPTDIPTLTIRLNATIKTEQNTENPKSPPKPTNFENTTIRIPKTLESATATTNATQKIESTTFTTIGIKEINGNTYSSPKNSIYLKSKSQQSTTKFTDAEHTTPILKFTTWQNTVRTYMSHNTEVQNMTDKFQRTTLKSSNELPTIQTLSVTPKQKLPSNVTAKTEVHITNNALPSSNSSYSITEVTKEVKHTRMSASTHEQINHTEIAQITPILNAHTSEKSTTPQRSFTAETFLTTSSKPNIITWSNLLTTTPKEPLTNTSLRWTDHITTQLTTSNRTQSAKLTKANISSQTTNIYPQTITGRSTEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q06094</accession>
    <name>GN_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Envelope glycoprotein N</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gN</name>
        <name type="ORF">BHRF1</name>
        <name type="ORF">U46</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carss A.L."/>
                <person name="Sun N."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1333836"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Also plays a critical role in virion morphogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with gM (via N-terminus). The gM-gN heterodimer forms the gCII complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus</location>
            <location evidence="1">Host trans-Golgi network</location>
        </subcellularLocation>
        <text evidence="1">When coexpressed with gM, localizes in the host trans-Golgi network.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae glycoprotein N family.</text>
    </comment>
    <dbReference type="EMBL" id="X64320">
        <property type="protein sequence ID" value="CAA45601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B56653">
        <property type="entry name" value="B56653"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042939.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q06094"/>
    <dbReference type="DNASU" id="1487925"/>
    <dbReference type="GeneID" id="1487925"/>
    <dbReference type="KEGG" id="vg:1487925"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044177">
        <property type="term" value="C:host cell Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033644">
        <property type="term" value="C:host cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04037">
        <property type="entry name" value="HSV_GN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005211">
        <property type="entry name" value="Herpes_glycoprotein_N_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034707">
        <property type="entry name" value="HSV_GN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03554">
        <property type="entry name" value="Herpes_UL73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-1040">Host Golgi apparatus</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0261">Viral envelope protein</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000116215" description="Envelope glycoprotein N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="topological domain" description="Virion surface" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="topological domain" description="Intravirion" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with gM)" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04037"/>
        </source>
    </evidence>
    <sequence length="84" mass="9778" checksum="F69617E96D763FBF" modified="1996-10-01" version="1" precursor="true">MSCKKSARQSLYVSLCLFYILVFAAATEVDFYSPECHSHTYEIVLNSFSSIWLLINLFLLLCSFAIFLKYWCYKTFASETVKGY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2021-06-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q06095</accession>
    <name>DUT_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="1">dUTPase</shortName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">DUT</name>
        <name type="ordered locus">U45</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="DNA Seq." volume="3" first="25" last="39">
            <title>Infectivity determinants encoded in a conserved gene block of human herpesvirus-6.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Carss A.L."/>
                <person name="Sun N."/>
                <person name="Arrand J.R."/>
            </authorList>
            <dbReference type="PubMed" id="1333836"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="X64320">
        <property type="protein sequence ID" value="CAA45600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X92436">
        <property type="protein sequence ID" value="CAA63171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A56653">
        <property type="entry name" value="A56653"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042938.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q06095"/>
    <dbReference type="PRIDE" id="Q06095"/>
    <dbReference type="DNASU" id="1487924"/>
    <dbReference type="GeneID" id="1487924"/>
    <dbReference type="KEGG" id="vg:1487924"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04031">
        <property type="entry name" value="HSV_DUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034745">
        <property type="entry name" value="HSV_DUT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182959" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04031"/>
        </source>
    </evidence>
    <sequence length="376" mass="43398" checksum="81B3CE9C817D27D5" modified="1995-11-01" version="1">MYSAISEKISETITLQRQTSSRYIEFFVFRNVDINELWTTDISEDKTHDVWPAVNEKSFKKFLENELTSYQRPIPLLGIPQNGTVSKTCKKEKQRETDCVNYERKRGNPVTFYPRHRAKRNANTDTCISEEPSILVSHHRNSKMDVFMDTNKITLVNRELIWVPHDQVRIVKLDISLYIPDGFFGVITGHSNDVFCECVTEIITDETDISVFLMNLSEHSLMLLPGDVEFSINFLPCYIPEPWEMINLSPPEFAIFHLKASREFIAKPNSYTIQYFDAMYVCADELKALMIPSKEIAKLGLLIETYIWNKDTIPSIKIFNSTRKTIYIPTGICIARIIFTCGHFCLSLMPERAINRLQVLDANSSFLFHYAASNNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q69545</accession>
    <accession>Q69587</accession>
    <name>LJ1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein LJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LJ1</name>
        <name type="synonym">SJLF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Oncogene" volume="9" first="1167" last="1175">
            <title>A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1.</title>
            <authorList>
                <person name="Thompson J."/>
                <person name="Choudhury S."/>
                <person name="Kashanchi F."/>
                <person name="Doniger J."/>
                <person name="Berneman Z."/>
                <person name="Frenkel N."/>
                <person name="Rosenthal L.J."/>
            </authorList>
            <dbReference type="PubMed" id="8134119"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="J. Gen. Virol." volume="76" first="451" last="458">
            <title>Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7844567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAA56193" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="X79798">
        <property type="protein sequence ID" value="CAA56193.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69545"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000342569" description="Uncharacterized protein LJ1">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="321" mass="36735" checksum="17F70902BEF9844B" modified="1996-11-01" version="1">MSAERSTARRGVSTRVRSTPSLARAGPPRERPRPFSLLRRILVCPLRLCLPSLSLSPSLAGAIGSSRSPSPLNYAPSAPIPSSALSGGAGGGSRIHDTRVFRARRLGPQPMGSFFHASRSGARVGEKHGASHSGVRARVGGWVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVRVSRWFPLAPCQATVGPRRWHVARDVVLNCLHVSPRYAPSTYPPATTTWVGCACLCVCVCTRPW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-02-23" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q69546</accession>
    <name>U6_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U6</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69546"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342582" description="Uncharacterized protein U6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <sequence length="82" mass="8877" checksum="091C28F7F80754B9" modified="1996-11-01" version="1">MFHTKQSEEGCSPLMPNLAAAVPCRPFVNLARETGTTNLLVAGSRPTNTGVRNFVINLTVGESSSSRRTANRILLRSFTSLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-02-23" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q69548</accession>
    <accession>Q69036</accession>
    <name>U13_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U13</name>
        <name type="synonym">EFRF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="sequence caution" evidence="1">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16718" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16718.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09305">
        <property type="entry name" value="T09305"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042905.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69548"/>
    <dbReference type="DNASU" id="1487895"/>
    <dbReference type="GeneID" id="1487895"/>
    <dbReference type="KEGG" id="vg:1487895"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342571" description="Uncharacterized protein U13">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="106" mass="12003" checksum="BBCBF6FF13782893" modified="1996-11-01" version="1">MAHAKKRVRRKLLTSTDDPILSNTFTMRPTSKIADAEIISREHDYIASKTQTDSKKISPLSVILDKTVLFEFYGIGDNNEKAIVYPIDPDFLLCDSEHNCTLSPFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q69549</accession>
    <accession>Q69037</accession>
    <name>PP85_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Phosphoprotein 85</fullName>
            <shortName>pp85</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein U14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">U14</name>
        <name type="synonym">EFRF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Host cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Expressed exclusively at the cytoplasmic level during the late phase of the virus replication cycle. Also found in dense bodies (By similarity).</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae pp85 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16719" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16719.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09306">
        <property type="entry name" value="T09306"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042906.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q69549"/>
    <dbReference type="PRIDE" id="Q69549"/>
    <dbReference type="DNASU" id="1487898"/>
    <dbReference type="GeneID" id="1487898"/>
    <dbReference type="KEGG" id="vg:1487898"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006731">
        <property type="entry name" value="Herpes_pp85"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04637">
        <property type="entry name" value="Herpes_pp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-0920">Virion tegument</keyword>
    <feature type="chain" id="PRO_0000342570" description="Phosphoprotein 85">
        <location>
            <begin position="1"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="609" mass="69560" checksum="7053B3F21CEFE66F" modified="1996-11-01" version="1">MVTHAMEEPKTFNIPTFVLDENCNFIPEVLSRANAKYIKDVLIQDSYNTVCLANSFIPMTIQTAEQIMVIITKFKFSRARDLFEKVLRLGVHINRFYAGKKQVKHMITMMKSLFDTEEAMRRLDRALMGLFVDARGSSYMPLIALSLHENGLPDSKFTKAVKLINTTLNSFHNRPDADIEQYAQKLRAYNYLYKIPHYTLKEAVDVYSENLKDLSIGVNKKPTLLFTSSDDGYLSHIFNDMLFLTSTWNMIYNCKVQIRRLTTWIKYEINSIVEDCVLVGFQLPDLKDTILDLAALTSNMNLVDPDKDLFSHYKLILEKLFEISIFATKANICILPTFIKSHLIEFEDVLKRSNDDEDLNYLLLKSNDSDDEYDEDKLPIQVDPGRVDNVLTDSNFFNVTADNAFSSIAIMPISYDKIIDVEENVIQVLEVEMQSLSAVVYGAVANKYGLSLPQVIKRLNQNEGRASSRASSSHSTSTIPYSPPQSGRSTPTSILRQRAPIRSNSRSSSVSFSQDDDNRSHYSDETNISDYSYPMADLDLEDEEPMEDHPHSPQSASSNNSMSRRSRALQNEQRRRTPTMAPPSPARGQNNARLRRRTRRSTETNDERL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q69550</accession>
    <accession>Q69038</accession>
    <name>U15_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U15</name>
        <name type="synonym">EFLF3</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16720" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16720.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09307">
        <property type="entry name" value="T09307"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042907.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69550"/>
    <dbReference type="DNASU" id="1487912"/>
    <dbReference type="GeneID" id="1487912"/>
    <dbReference type="KEGG" id="vg:1487912"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008644">
        <property type="entry name" value="Herpes_U15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05613">
        <property type="entry name" value="Herpes_U15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000342572" description="Uncharacterized protein U15">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="110" mass="13415" checksum="F08223B9DC2C80B7" modified="1996-11-01" version="1">MDVWKRQRLQECRELCPLPVLMSLSNMFSKIEIVYVKYLFKMDFSTMYRYILPALTLSMTVTKSLVIEMLFILKRWEDIDQFFRLNIRKVNDCFIVAQFNHIPIKRWVLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q69551</accession>
    <accession>Q76VQ2</accession>
    <accession>Q89432</accession>
    <name>U16_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U17/U16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U17/U16</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS 2 AND 3)</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Isoform 3 can transactivate the human immunodeficiency virus type 1 promoter.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q69551-1</id>
            <name>1</name>
            <name>Protein U17/U16</name>
            <name>Protein U16exon1-2</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q69552-1</id>
            <name>2</name>
            <name>Protein U17</name>
            <name>EFLF1</name>
            <sequence type="external"/>
        </isoform>
        <isoform>
            <id>Q69551-2</id>
            <name>3</name>
            <name>Protein U16</name>
            <name>EFLF2</name>
            <sequence type="described" ref="VSP_034621"/>
        </isoform>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae US22 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAA16721" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58395" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58396" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="M81789">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16721.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58395.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58396.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09308">
        <property type="entry name" value="T09308"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69551"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003360">
        <property type="entry name" value="US22-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02393">
        <property type="entry name" value="US22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0025">Alternative splicing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000343647" description="Protein U17/U16">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="splice variant" id="VSP_034621" description="In isoform 3." evidence="2">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; M81789." evidence="2" ref="1">
        <original>Y</original>
        <variation>C</variation>
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; M81789." evidence="2" ref="1">
        <original>D</original>
        <variation>H</variation>
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; M81789." evidence="2" ref="1">
        <original>N</original>
        <variation>S</variation>
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; M81789." evidence="2" ref="1">
        <original>I</original>
        <variation>N</variation>
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="334" mass="38493" checksum="9627082A31D3CECA" modified="2008-07-22" version="2">MADERTSDSVKTRYDIALMKLNDIKIAVFRDSLSTYVEQKTGLTIQFNWPKSRCLVISTLCKIPFPTKSAAELQEMCSLLLCCPERLQLLGYVSVWGEETRDVCLTKTLVFAGEDEKFYGLDFVNETLYLLAETTERFAVLGLRRYDPVYREKDIRFLTKIDDVLQSLIDAQDNLWKFATIVYKNSGRHYIMKSCLENNDGVFVLFLTRKEDFPSRMEWNFFSDVYESMPYDGQVIGSIGKTLLYPKTMFVMMDLSGAIYGIDTIGTGIGSCVKIADDFESFLRQGIVRGYRRYKFFHRNINTVQEILPLCPHTSLGPTFSNNYIYDLSSEDDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q69552</accession>
    <accession>Q69039</accession>
    <name>U17_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U17/U16</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>ALTERNATIVE SPLICING (ISOFORMS 1 AND 3)</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q69552-1</id>
            <name>2</name>
            <name>Protein U17</name>
            <name>EFLF1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q69551-1</id>
            <name>1</name>
            <name>Protein U17/U16</name>
            <name>Protein U16exon1-2</name>
            <sequence type="external"/>
        </isoform>
        <isoform>
            <id>Q69551-2</id>
            <name>3</name>
            <name>Protein U16</name>
            <name>EFLF2</name>
            <sequence type="external"/>
        </isoform>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16722" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16722.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09309">
        <property type="entry name" value="T09309"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042910.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69552"/>
    <dbReference type="DNASU" id="1487923"/>
    <dbReference type="GeneID" id="1487923"/>
    <dbReference type="KEGG" id="vg:1487923"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0025">Alternative splicing</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000343648" description="Protein U17">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="133" mass="15538" checksum="441A1292EB7E7CA1" modified="1996-11-01" version="1">MADERTSDSVKTRYDIALMKLNDIKIAVFRDSLSTYVEQKTGLTIQFNWPKSRCLVISTLCKIPFPTKSAAELQEMCKYQCFVSVLWCVILVFVVKIKLFFLLNKVRYYFAARKDCNYLDMFLSGERRLVMCA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q69553</accession>
    <accession>Q69041</accession>
    <name>U18_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Putative immediate early glycoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein U18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">U18</name>
        <name type="synonym">EJLF6</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae immediate early glycoprotein family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16724" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16724.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09311">
        <property type="entry name" value="T09311"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042911.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69553"/>
    <dbReference type="DNASU" id="1487934"/>
    <dbReference type="GeneID" id="1487934"/>
    <dbReference type="KEGG" id="vg:1487934"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010880">
        <property type="entry name" value="Herpes_UL37_HHV-5-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07413">
        <property type="entry name" value="Herpes_UL37_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000342573" description="Putative immediate early glycoprotein">
        <location>
            <begin position="22"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="293" mass="33218" checksum="962D8C6368EE58FF" modified="1996-11-01" version="1" precursor="true">MKKLTMESLSVYIFVMGVCFTSNFTCEQKIVLIQEHKLRSICISTCYVNGVLAGNSSCVSVKTSYLINLAMLTNGFKAMRVGNITSISEKTAFLRVIINYYFRGVMLRALIAQRLPNAANLSSTVNCWLDDHSAGGVMTLFYGTERIVLNSSTEINASRWISDGQDANGTLNILNERVSLDIYFLSKICPQLSSEIYKKKVAHPKYFSLIKNDTKPKKFLRNTWRSAWSNWYKYKEIKEFLDFSSDYENFSEITYSMSAAGLFFLAGGAFTMLLLLCCLSMITRKHIVKDLGY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-02-23" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q69554</accession>
    <accession>Q69043</accession>
    <name>UL38_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Apoptosis inhibitor U19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U19</name>
        <name type="synonym">EJLF4</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication. Promotes stabilization and inactivation of host TP53 through interaction with host MDM2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with host MDM2; this interaction leads to the stabilization of host TP53.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">localized in the host nucleus at early times postinfection and then increases in both nuclear and cytoplasmic compartments during the course of infection.</text>
    </comment>
    <comment type="similarity">
        <text>Belongs to the beta-herpesvirinae UL38 protein family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16726" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16726.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09313">
        <property type="entry name" value="T09313"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042912.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69554"/>
    <dbReference type="DNASU" id="1487945"/>
    <dbReference type="GeneID" id="1487945"/>
    <dbReference type="KEGG" id="vg:1487945"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-1119">Modulation of host cell apoptosis by virus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342574" description="Apoptosis inhibitor U19">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="F5HG98"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9WT45"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="389" mass="43316" checksum="A2151E588BECC0BE" modified="1996-11-01" version="1">MAFTGDELARMLQFKDKMISSAGLALKFEKVVQEAMASGIVLQHITCIKVRICDNSDILSDRQLRSLLINGLYPFEGRMSMFGVTEEWEGASAAPERQVVFLLSSTGQVLGYEDGVVFYLSPTFSDFWTTAMEFSCQNAILSNFIAQKSRDEYIDQFQKYFTRMRHTPIFLTGVLPRRFQKVESSACVEEDARASMRPIQCDSFGVKDTFCRPTEELLQPSANKDVGGKVCMSLSCREDNSARHCTIYGLTETRGIKIMFSRHTQTDRSEVMCNAATQTGDVVDNSSETLFLGKNLVHQSILETEVKTTAKNTFDVSNPRIDSVYDTTVFGAMATDDVGCENVQGGASLAQEKPLKGYCITATPSECKPNIHWLKSPEKTVQESAAVLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q69555</accession>
    <accession>Q69044</accession>
    <name>U20_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Glycoprotein U20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U20</name>
        <name type="synonym">EJLF3</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16727" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16727.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09314">
        <property type="entry name" value="T09314"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042913.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69555"/>
    <dbReference type="DNASU" id="1487956"/>
    <dbReference type="GeneID" id="1487956"/>
    <dbReference type="KEGG" id="vg:1487956"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000342576" description="Glycoprotein U20">
        <location>
            <begin position="16"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="422" mass="48688" checksum="AD90E1C03F61EE67" modified="1996-11-01" version="1" precursor="true">MITVFVACLFQCVSSLPAKLYIKTTLAERIGKLQTVIGIDNDIVFAYERLYEDLTLLNHTVVGETLFDLTGSLEEGKNSTVDRFLGHVVIREFHRLHAGLQYVSLRNFSVSELVCFVNNNTQLSGSYVFLAGNTTYVQIDLFNENRGFVHDLINLSSFLQNRSLHVLSFYARRFCVEDILNFYGKVVFGDSRHRPPQVFSKRDTGLLVCTARRYRPIGTNIQWSIQNQTVSDDHMTDDFIRTEIAGQLLYSYERALSRALSMTQRNFSCEITHKLLVTPALLTREDAFSFKGFVNPVKQSEDMFPRHNFPAPHRKKFNKLQLLWIFTVIPIAAGCMFVYMLTRYILFFVSGGCSLNPNRVLKRRRRNDEVPMVIMEVEYCNYEADDYMELHSVQKVRDNSIAVVCGNNSFDIERQSKISRNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q69556</accession>
    <accession>Q69045</accession>
    <name>U21_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Glycoprotein U21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U21</name>
        <name type="synonym">EJLF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to MHC class I molecules in the endoplasmic reticulum and targets them from the Golgi directly to the lysosomes. Once in the lysosomes both proteins are degraded. In consequence, surface class I molecules are down-regulated and infected cells are masked for immune recognition by cytotoxic T lymphocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The ER-lumenal domain associates with class I MHC molecules and is responsible for lysosomal sorting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviruses U21 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16728" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16728.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09315">
        <property type="entry name" value="T09315"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042914.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69556"/>
    <dbReference type="DNASU" id="1487967"/>
    <dbReference type="GeneID" id="1487967"/>
    <dbReference type="KEGG" id="vg:1487967"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044167">
        <property type="term" value="C:host cell endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1038">Host endoplasmic reticulum</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0899">Viral immunoevasion</keyword>
    <feature type="chain" id="PRO_0000116355" description="Glycoprotein U21">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="386"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="433" mass="49395" checksum="054834689F77A436" modified="1996-11-01" version="1">MMICLVFLCVLTLARGEIYPPICPAPGVGNDEAVRAGELLLEISAYRNQRSGRVELWGSAAVNNQVFYGGMENSQIDYDFGKFLVFRCFQVFNNVHKLLFNTVSSATMHLARKRVQKCGHGKMTFISIQVQCSVNKKSIRLSRMSEASLKKQVLRVAFFLDRNNNSWIADKNFQGEDRTMLRLWNELSTYQQYLISSCNNDVKILSELYGEFRQIALPYDEKLNLNFMPVIRSSSERLFRADDLKCSFSRWLGAEGEFAVCEYSGWGVSRLGKIEIFAEKPLTFDMAWKTVKMRSSGAYTSLFRDDVTWGLIPLDKWVGDKYFCMCTNKESGDNVIVTLPEKNVEKSIQIYDEGSAMLSFAEMTSIILNLMFMGAVAVSVGILGISCFVGLKEIIYFIFVSVDYMWPFCDTLLTTAVNCFFKGRTFLRRELKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q69557</accession>
    <accession>Q69046</accession>
    <name>U22_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Glycoprotein U22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U22</name>
        <name type="synonym">EJLF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16729" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16729.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09316">
        <property type="entry name" value="T09316"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042915.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69557"/>
    <dbReference type="DNASU" id="1487978"/>
    <dbReference type="GeneID" id="1487978"/>
    <dbReference type="KEGG" id="vg:1487978"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000342577" description="Glycoprotein U22">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="202" mass="23408" checksum="4E6DFA4E02D7A57E" modified="1996-11-01" version="1" precursor="true">MVPQGCSLVWVSALYVSVIASLHIINNENSVFIATHSETELRHWLIFVKMAQRNGTAWWRMASVPINAYFERDIAFLFNPRCVIETAMGSKILCRYNKNIGVVFVDNDTKCNVSFPSGVQLQLLNQSVMESIRTKTYVVDYARKTTERGDCFISVAFCRKERRRFLSRCERFVYYCISVYLFAVVVLCSCWFALDPLFNMWA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-02-23" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q69558</accession>
    <accession>Q69047</accession>
    <name>U23_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Glycoprotein U23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U23</name>
        <name type="synonym">EqLF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16730" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16730.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09317">
        <property type="entry name" value="T09317"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042916.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q69558"/>
    <dbReference type="PRIDE" id="Q69558"/>
    <dbReference type="DNASU" id="1487989"/>
    <dbReference type="GeneID" id="1487989"/>
    <dbReference type="KEGG" id="vg:1487989"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000342578" description="Glycoprotein U23">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="236" mass="26523" checksum="C4CF8711102EEDC4" modified="1996-11-01" version="1" precursor="true">MLFLSFLLVCLCEEVRMLNLMTTEVSATEFASIASKNMETDVSTSSDYLTGKSETTFSANSETWGKNVTEISIDSETYLNQSFMVTSTLAVETTDRSIGNNVNVTSSFPTVKGDETQNIETSFTVISASTFSDVSEKTPQGLSTKSTPKKTVQALWETDTVQVLEFTDTHEGDEEYFKDFLSSLVIWIGGISFIGAFVILIVILCNWYKKDKQRSLFWDEEKKPDVQMRRDVKTCR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-02-23" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q69559</accession>
    <accession>Q69048</accession>
    <name>U24_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>U24 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U24</name>
        <name type="synonym">EoLF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="J. Virol." volume="82" first="602" last="608">
            <title>Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein.</title>
            <authorList>
                <person name="Sullivan B.M."/>
                <person name="Coscoy L."/>
            </authorList>
            <dbReference type="PubMed" id="17977973"/>
            <dbReference type="DOI" id="10.1128/jvi.01571-07"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>GS</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="J. Virol." volume="84" first="1265" last="1275">
            <title>The U24 protein from human herpesvirus 6 and 7 affects endocytic recycling.</title>
            <authorList>
                <person name="Sullivan B.M."/>
                <person name="Coscoy L."/>
            </authorList>
            <dbReference type="PubMed" id="19923186"/>
            <dbReference type="DOI" id="10.1128/jvi.01775-09"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF 8-PRO--TYR-11; 7-PRO--PRO-9 AND 53-ARG--ARG-55</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>GS</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2017" name="Sci. Rep." volume="7" first="39776" last="39776">
            <title>U24 from Roseolovirus interacts strongly with Nedd4 WW Domains.</title>
            <authorList>
                <person name="Sang Y."/>
                <person name="Zhang R."/>
                <person name="Scott W.R."/>
                <person name="Creagh A.L."/>
                <person name="Haynes C.A."/>
                <person name="Straus S.K."/>
            </authorList>
            <dbReference type="PubMed" id="28051106"/>
            <dbReference type="DOI" id="10.1038/srep39776"/>
        </citation>
        <scope>PHOSPHORYLATION AT THR-6</scope>
        <scope>INTERACTION WITH NEDD4 WW DOMAINS</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="4447" last="4447">
            <title>Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases.</title>
            <authorList>
                <person name="Koshizuka T."/>
                <person name="Kobayashi T."/>
                <person name="Ishioka K."/>
                <person name="Suzutani T."/>
            </authorList>
            <dbReference type="PubMed" id="29535361"/>
            <dbReference type="DOI" id="10.1038/s41598-018-22682-2"/>
        </citation>
        <scope>INTERACTION WITH HOST ITCH</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF TYR-11</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Down-regulates the TCR/CD3E complex and the transferrin receptor TFRC in host T-cells by blocking them from recycling back to the cell surface.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Interacts with host ITCH; this interaction probably mediates ITCH degradation (Probable). Interacts probably with NEDD4.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-8015758">
            <id>Q69559</id>
        </interactant>
        <interactant intactId="EBI-959949">
            <id>P28482</id>
            <label>MAPK1</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Contains one L domain: a PPXY motif which is involved in the interaction with Itch, a member of the Nedd4 family.</text>
    </comment>
    <comment type="sequence caution" evidence="6">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16731" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16731.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09318">
        <property type="entry name" value="T09318"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042917.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q69559"/>
    <dbReference type="IntAct" id="Q69559">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MINT" id="Q69559"/>
    <dbReference type="iPTMnet" id="Q69559"/>
    <dbReference type="PRIDE" id="Q69559"/>
    <dbReference type="DNASU" id="1487899"/>
    <dbReference type="GeneID" id="1487899"/>
    <dbReference type="KEGG" id="vg:1487899"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000342579" description="U24 protein">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PPXY motif" evidence="5">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="4">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Complete loss of the ability to down-regulate the TCR complex." evidence="3">
        <original>PPP</original>
        <variation>AAA</variation>
        <location>
            <begin position="7"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Complete loss of the ability to down-regulate the TCR complex." evidence="3">
        <original>PPSY</original>
        <variation>AAA</variation>
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Complete loss of interaction with host ITCH." evidence="5">
        <original>Y</original>
        <variation>A</variation>
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Almost complete loss of the ability to down-regulate the TCR complex." evidence="3">
        <original>RRK</original>
        <variation>QQQ</variation>
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="17977973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19923186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="28051106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="29535361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="28051106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="29535361"/>
        </source>
    </evidence>
    <sequence length="87" mass="10091" checksum="494C1B4088A5C923" modified="1996-11-01" version="1">MDPPRTPPPSYSEVLMMDVMCGQVSPHVINDTSFVECIPPPQSRPAWNLWNNRRKTFSFLVLTGLAIAMILFIVFVLYVFHVNRQRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q69560</accession>
    <name>SCP_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small capsomere-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SCP</name>
        <name type="synonym">U32</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the major capsid protein and small capsomere-interacting protein/SCP assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the major capsid protein/MCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae small capsomere-interacting protein family.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042925.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q69560"/>
    <dbReference type="PRIDE" id="Q69560"/>
    <dbReference type="DNASU" id="1487909"/>
    <dbReference type="GeneID" id="1487909"/>
    <dbReference type="KEGG" id="vg:1487909"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04021">
        <property type="entry name" value="HSV_SCP_betahv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031385">
        <property type="entry name" value="HV_small_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17086">
        <property type="entry name" value="HV_small_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0167">Capsid protein</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000342580" description="Small capsomere-interacting protein">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="88" mass="9741" checksum="AC2A594D43719B53" modified="1996-11-01" version="1">MTTIRSDDLSNQITQISGSSKKEEEKKKQQMLTGVLGLQPNMASHPVLGVFLPKYAKQNGGNVDKTAFRLDLIRMLALHRLNTKTGSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-02-23" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q69561</accession>
    <accession>Q69058</accession>
    <name>TRM2_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tripartite terminase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRM2</name>
        <name type="ordered locus">U35</name>
        <name type="ordered locus">XILF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with TRM1 and TRM3 to form the tripartite terminase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <text evidence="1">Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae TRM2 protein family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16742" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16742.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09329">
        <property type="entry name" value="T09329"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042928.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q69561"/>
    <dbReference type="PRIDE" id="Q69561"/>
    <dbReference type="DNASU" id="1487913"/>
    <dbReference type="GeneID" id="1487913"/>
    <dbReference type="KEGG" id="vg:1487913"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04015">
        <property type="entry name" value="HSV_TRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005208">
        <property type="entry name" value="Herpes_TT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03581">
        <property type="entry name" value="Herpes_UL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0231">Viral genome packaging</keyword>
    <keyword id="KW-1188">Viral release from host cell</keyword>
    <feature type="chain" id="PRO_0000342586" description="Tripartite terminase subunit 2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="106" mass="12440" checksum="CC7712372EBE783F" modified="1996-11-01" version="1">MMDSSPEKTNLELLYERVCEQGREFEVVFYPMLPRLYEMMLPSLEARLNFLSVGYRHVAFARYVHGDVDCVHREVMAQKMVLLTSILSKLLNVNGILEHQEYLNTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-02-23" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q69562</accession>
    <name>U61_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U61</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U61</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69562"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342581" description="Uncharacterized protein U61">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <sequence length="115" mass="13578" checksum="40821060372155C7" modified="1996-11-01" version="1">MAAESTLRGKDSTCSTIKLQFLLILSIILKRSSFVSQFSKSSFIPFNAEFIPLSEYTRTELQSAYCRREPLYKERRVQHDFRFPAPSIYQDPIYIFDQFRKPFNIFFNEAEQLSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-02-23" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q69566</accession>
    <name>U88_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U88</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69566"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000342584" description="Uncharacterized protein U88">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="413" mass="44135" checksum="6306069949151A4D" modified="1996-11-01" version="1">MYVSVSVHVSVHVSVRVSVRVSVCVSVRVSVHVSVRVSVSVRVSVRVSVSVRVSVRVSVSVHVSVRVSVRVSVSVRVSVCARVCARVCVCARVCVCARVCVCARVCVCARVCARVCVCACVCVCACLCVCACLCVCACLCVCACLCVCACLCVCACLCVCACLCVCACLCVCVCVCLCVCVCLCVCVCLCVCVCLCVCVCLCVCVCLCVCVCLCVCVCLCVCVCLCVCVCLCVCVCVCVCVCVCVCVCVCVCVCVCLCVCVCLCVCLCVCLCVCVCVCVCLCVCLCVCLCVCVCVCVCLLCMSLCMCMCMCMCMCMCMCMCMSLCMSLCMCMCMCMCMCMCICMCMCICICMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCMCIIEGNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q69567</accession>
    <accession>Q69227</accession>
    <accession>Q69228</accession>
    <accession>Q69229</accession>
    <accession>Q69568</accession>
    <name>IE1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Immediate-early protein 1</fullName>
            <shortName>IE1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein RF2/RF3/RF4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>pRF2/pRF3/pRF4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">U90/U89</name>
        <name type="synonym">RF4</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1991" name="J. Virol." volume="65" first="5381" last="5390">
            <title>Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6.</title>
            <authorList>
                <person name="Martin M.E.D."/>
                <person name="Nicholas J."/>
                <person name="Thomson B.J."/>
                <person name="Newman C."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1654446"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Virus Res." volume="89" first="89" last="101">
            <title>Identification and characterization of the gene products of open reading frame U86/87 of human herpesvirus 6.</title>
            <authorList>
                <person name="Papanikolaou E."/>
                <person name="Kouvatsis V."/>
                <person name="Dimitriadis G."/>
                <person name="Inoue N."/>
                <person name="Arsenakis M."/>
            </authorList>
            <dbReference type="PubMed" id="12367753"/>
            <dbReference type="DOI" id="10.1016/S0168-1702(02)00126-0"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q69567-1</id>
            <name>2</name>
            <name>IE1 protein</name>
            <name>Protein U90-U89</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q77Z83-1</id>
            <name>1</name>
            <name>IE2 protein</name>
            <name>Protein U90-U86/87</name>
            <sequence type="external"/>
        </isoform>
        <isoform>
            <id>Q77Z83-2</id>
            <name>3</name>
            <name>IE-100</name>
            <sequence type="external"/>
        </isoform>
        <isoform>
            <id>Q77Z83-3</id>
            <name>4</name>
            <name>IE-55</name>
            <sequence type="external"/>
        </isoform>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAA43849" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAA43850" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="AAA43851" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58339" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="M73681">
        <property type="protein sequence ID" value="AAA43849.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M73681">
        <property type="protein sequence ID" value="AAA43850.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M73681">
        <property type="protein sequence ID" value="AAA43851.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58339.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B40506">
        <property type="entry name" value="B40506"/>
    </dbReference>
    <dbReference type="PIR" id="C40506">
        <property type="entry name" value="C40506"/>
    </dbReference>
    <dbReference type="PIR" id="D40506">
        <property type="entry name" value="D40506"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042983.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69567"/>
    <dbReference type="DNASU" id="1487968"/>
    <dbReference type="GeneID" id="1487968"/>
    <dbReference type="KEGG" id="vg:1487968"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005507">
        <property type="entry name" value="HHV6-IE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03753">
        <property type="entry name" value="HHV6-IE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0025">Alternative splicing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000343644" description="Immediate-early protein 1">
        <location>
            <begin position="1"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="941" mass="104648" checksum="8E93A6E7D5EB1935" modified="2008-07-22" version="2">MEPAKPSGNNMGSNDERMQDYRPDPMMEESIKEILEESLMCDTSFDDLIIPGLESFGLIIPESSNNIESNNVEEGSDGELKTLAAQSAGNCIQSIGASVKAAMKQEQSDMEDKLIKCAGLLTQQQSMFIGLGLEQLSQLININLLSSASTKYVESYSKMLHGKELDFFNWCEPRFIVFACDKFDGLVKKVASESRNLLLDLRANMNNDIIKAVKDIFSKATVTLDCQKLNQGATMLMMMAHNKEMSNPDISSKDFCEKINTLKQTLLEGKNEIVETNAKNMQILQTFAIKQMNQIFMDGCDKAFLKLNVNCKNLITAAKNLANTILQSIVICSNEFSWQHLKLLRRGFKVTMLNMITQACECLESDYDDTGLIKPLTPLQIMDGYINMNKNRQSSICDGNTDPSDSMILDLADFDDHGRYSEESSIESIHEDDDNKMYPCTPSPEVPGKSKYVGTFTENSRQSGDEQTNPNCVGTASVTDLGGPDNLNSISGLQSCKNMLLERLLDTQCDSVVEGTEQDGSYGNTLISEMMMFGYETDHSAPYESESDNNDEIDYIANSDSAARTNNIHMNSTDENTPFSNSICSPPEVTPSKKNVKPKSMTPGSKPKKRVAKRKHVSSKSPKNKKIKTDQLPKAADVIVISSESEDEEDGDNIIGNSILIKAIKSESDSESSSESNDCTSEHKQLHLSDYDEVTNNGHCPSYGFPTPVFTIPIRSMQGTGGIKSKFIPKKNWIWYMKKTHQVDNCPIHNSENVDAKDDSDGTEAKHCFMNHFVPIKTDDEDYDKNNVSYIYNKIQNSKIDSGDIIPTKKLIIDMVMDNFMDLNDIIKQGITKHCQDLCNKYNVVTPTTCEDDLNMTNSQTFATTATQVFDPPVTGNNSSILNIINDTTSQNDENRCTEGTSNSNEKCTNISDCNSDGTEAFKLDGYPSDYDPFVENAQIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q69569</accession>
    <accession>Q96893</accession>
    <name>U91_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U91</name>
        <name type="synonym">HCRF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1649" last="1660">
            <title>The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1321205"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="miscellaneous discrepancy">
            <sequence resource="EMBL-CDS" id="BAA01905" version="1"/>
        </conflict>
        <text>Unusual initiator. The initiator methionine may be coded by a non-canonical AAG methionine codon.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="miscellaneous discrepancy">
            <sequence resource="EMBL-CDS" id="CAA58340" version="1"/>
        </conflict>
        <text>Unusual initiator. The initiator methionine may be coded by a non-canonical AAG methionine codon.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58340.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="D11134">
        <property type="protein sequence ID" value="BAA01905.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1629">
        <property type="entry name" value="JQ1629"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042984.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="Q69569"/>
    <dbReference type="PRIDE" id="Q69569"/>
    <dbReference type="DNASU" id="1487969"/>
    <dbReference type="GeneID" id="1487969"/>
    <dbReference type="KEGG" id="vg:1487969"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000343645" description="Uncharacterized protein U91">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="114" mass="12872" checksum="356510427E6A2F33" modified="2008-07-22" version="2" precursor="true">MICLFYFNVLIIYLHTFLKNEKKNITDGLFLDSVTSQAMENKESMKKNEGEPPVWIQALTTTLSIILLVCIIMACIICSRTTEEEKSEMQSSASSVETLQSLNEAIFPKGEMNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q69572</accession>
    <accession>Q69573</accession>
    <accession>Q69574</accession>
    <accession>Q69575</accession>
    <accession>Q69576</accession>
    <accession>Q76WN9</accession>
    <name>GQ1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Glycoprotein Q1</fullName>
            <shortName>gQ1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Glycoprotein 105</fullName>
            <shortName>gp105</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Glycoprotein Q-80k</fullName>
            <shortName>gQ-80k</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>HCLF1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">U100</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1649" last="1660">
            <title>The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1321205"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="J. Virol." volume="69" first="3490" last="3500">
            <title>Identification and characterization of a cDNA derived from multiple splicing that encodes envelope glycoprotein gp105 of human herpesvirus 6.</title>
            <authorList>
                <person name="Pfeiffer B."/>
                <person name="Thomson B."/>
                <person name="Chandran B."/>
            </authorList>
            <dbReference type="PubMed" id="7745696"/>
        </citation>
        <scope>ALTERNATIVE SPLICING (ISOFORMS GQ1 AND GQ2)</scope>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Virol." volume="77" first="2452" last="2458">
            <title>The human herpesvirus 6 U100 gene product is the third component of the gH-gL glycoprotein complex on the viral envelope.</title>
            <authorList>
                <person name="Mori Y."/>
                <person name="Akkapaiboon P."/>
                <person name="Yang X."/>
                <person name="Yamanishi K."/>
            </authorList>
            <dbReference type="PubMed" id="12551983"/>
            <dbReference type="DOI" id="10.1128/JVI.77.4.2452-2458.2003"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
        <scope>INTERACTION WITH GH AND GL</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="7969" last="7983">
            <title>Intracellular processing of human herpesvirus 6 glycoproteins Q1 and Q2 into tetrameric complexes expressed on the viral envelope.</title>
            <authorList>
                <person name="Akkapaiboon P."/>
                <person name="Mori Y."/>
                <person name="Sadaoka T."/>
                <person name="Yonemoto S."/>
                <person name="Yamanishi K."/>
            </authorList>
            <dbReference type="PubMed" id="15254169"/>
            <dbReference type="DOI" id="10.1128/JVI.78.15.7969-7983.2004"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH GLYCOPROTEIN Q2</scope>
        <scope>INTERACTION WITH GH/GL</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2010" name="Virology" volume="407" first="360" last="367">
            <title>Human herpesvirus 6 encoded glycoprotein Q1 gene is essential for virus growth.</title>
            <authorList>
                <person name="Tang H."/>
                <person name="Kawabata A."/>
                <person name="Yoshida M."/>
                <person name="Oyaizu H."/>
                <person name="Maeki T."/>
                <person name="Yamanishi K."/>
                <person name="Mori Y."/>
            </authorList>
            <dbReference type="PubMed" id="20863544"/>
            <dbReference type="DOI" id="10.1016/j.virol.2010.08.018"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="J. Virol." volume="85" first="12962" last="12971">
            <title>Analysis of a neutralizing antibody for human herpesvirus 6B reveals a role for glycoprotein Q1 in viral entry.</title>
            <authorList>
                <person name="Kawabata A."/>
                <person name="Oyaizu H."/>
                <person name="Maeki T."/>
                <person name="Tang H."/>
                <person name="Yamanishi K."/>
                <person name="Mori Y."/>
            </authorList>
            <dbReference type="PubMed" id="21957287"/>
            <dbReference type="DOI" id="10.1128/JVI.05622-11"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="J. Virol." volume="87" first="7054" last="7063">
            <title>Identification of the human herpesvirus 6A gQ1 domain essential for its functional conformation.</title>
            <authorList>
                <person name="Maeki T."/>
                <person name="Hayashi M."/>
                <person name="Kawabata A."/>
                <person name="Tang H."/>
                <person name="Yamanishi K."/>
                <person name="Mori Y."/>
            </authorList>
            <dbReference type="PubMed" id="23596294"/>
            <dbReference type="DOI" id="10.1128/JVI.00611-13"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2014" name="Microbiol. Immunol." volume="58" first="22" last="30">
            <title>Human herpesvirus-6A gQ1 and gQ2 are critical for human CD46 usage.</title>
            <authorList>
                <person name="Jasirwan C."/>
                <person name="Furusawa Y."/>
                <person name="Tang H."/>
                <person name="Maeki T."/>
                <person name="Mori Y."/>
            </authorList>
            <dbReference type="PubMed" id="24215487"/>
            <dbReference type="DOI" id="10.1111/1348-0421.12110"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Plays a role in virus entry by participating in host receptor binding at the cell surface.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4 8">Interacts with isoform gQ2. Associates with the glycoprotein complex gH-gL (PubMed:12551983, PubMed:15254169). The gH/gL/gQ1/gQ2 complex binds to human receptor CD46 (PubMed:24215487).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Host endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q69572-1</id>
            <name evidence="9">Glycoprotein Q1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P0DOE0-1</id>
            <name evidence="9">Glycoprotein Q2</name>
            <sequence type="external"/>
        </isoform>
        <isoform>
            <id>P0DOE0-2</id>
            <name evidence="10">Glycoprotein Q0</name>
            <sequence type="external"/>
        </isoform>
    </comment>
    <comment type="PTM">
        <text evidence="3 4">Glycosylated by host.</text>
    </comment>
    <comment type="miscellaneous">
        <molecule>Isoform Glycoprotein Q1</molecule>
        <text>Transcribed from a highly spliced mRNA.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="BAA01908" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58346" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58347" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58348" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58349" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="D11134">
        <property type="protein sequence ID" value="BAA01908.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58346.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58347.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58348.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58349.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1632">
        <property type="entry name" value="JQ1632"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042993.3">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69572"/>
    <dbReference type="DNASU" id="1487972"/>
    <dbReference type="GeneID" id="1487972"/>
    <dbReference type="KEGG" id="vg:1487972"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0025">Alternative splicing</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1038">Host endoplasmic reticulum</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-0426">Late protein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-1161">Viral attachment to host cell</keyword>
    <keyword id="KW-1234">Viral attachment to host entry receptor</keyword>
    <keyword id="KW-0261">Viral envelope protein</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-1160">Virus entry into host cell</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000343642" description="Glycoprotein Q1" evidence="3">
        <location>
            <begin position="33"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="2">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12551983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15254169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="20863544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21957287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="23596294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="24215487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="12551983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="15254169"/>
        </source>
    </evidence>
    <sequence length="524" mass="59592" checksum="4BE0B38D807CA5A3" modified="2016-11-02" version="3" precursor="true">MATARLSAMKPPRSCALIFLCAFSMATAPTNATAHRRAGTVKSTPPPEDKHSYTAKYYDKDIYFNIYEGRNSTPRRRTLSEIISKFSTSEMLSLKRVKAFVPVDENPTTTLEDIADILNYAVCDDNSCGCTIETQARIMFGDIIICVPLSADNKGVRNFKDRIMPKGLSQILSSSLGLHLSLLYGAFGSNYNSLAYMRRLKPLTAMTAIRFCPMTTKLELRQNYKVKETLCELIVSIEILKIRNNGGQTMKTLTSFAIVRKDNDGQDWETCTRFAPVNIEDILRYKRVANDTCCRHRDVQHGRRTLESSNSWTQTQYFEPWQDIVDVYVPINDTHCPNDSYVVFETLQGFEWCSRLNKNETKNYLSSVLGFRNALFETEELMETIAMRLASQILSMVGQQGTTIRDIDPAIVSALWHSLPENLTTTNIKYDIASPTHMRPALCTIFVQTGTSKQRFRNAGLLMVNNIFTVQGRYTTQNMFERKEYVYKHLGQALCQGGHVFYNPKEVKSENIKMINIKPTVVRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-02-23" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q69577</accession>
    <accession>Q69544</accession>
    <name>RJ1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein RJ1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein LT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RJ1</name>
    </gene>
    <gene>
        <name type="primary">LT1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (RJ1)</scope>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-113 (LT1)</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="J. Virol." volume="73" first="8053" last="8063">
            <title>Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B.</title>
            <authorList>
                <person name="Isegawa Y."/>
                <person name="Mukai T."/>
                <person name="Nakano K."/>
                <person name="Kagawa M."/>
                <person name="Chen J."/>
                <person name="Mori Y."/>
                <person name="Sunagawa T."/>
                <person name="Kawanishi K."/>
                <person name="Sashihara J."/>
                <person name="Hata A."/>
                <person name="Zou P."/>
                <person name="Kosuge H."/>
                <person name="Yamanishi K."/>
            </authorList>
            <dbReference type="PubMed" id="10482554"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">RJ1 and LT1 genes probably code for identical proteins.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q69577"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000343646" description="Protein RJ1">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="143" mass="16220" checksum="AC5877157D668783" modified="1996-11-01" version="1" precursor="true">MARVMTRGMARVSTLATVRVSTLARARFSVRDSFMVSVIVGVRVRVDVLVRVNVLVRARPRVRVRARPRVRVRVRARPRVRVRVRASPRVRVRVITPPFFSPPGGFDVIFKTRGIPSPGETVLDKKVSRPWRGLTSRRGATMI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q77Z83</accession>
    <accession>O42080</accession>
    <accession>Q69471</accession>
    <accession>Q69564</accession>
    <name>IE2_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Immediate-early protein 2</fullName>
            <shortName>IE2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U90/U87/U86</name>
        <name type="synonym">BCLF0</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="submission" date="1997-07" db="EMBL/GenBank/DDBJ databases">
            <title>Identification of an human herpesvirus-6 transcription unit homologous to the immediate-early 2 gene of human cytomegalovirus -- evidence for an early/late gene.</title>
            <authorList>
                <person name="Soergel A."/>
                <person name="Schiewe U."/>
                <person name="Fleckenstein B."/>
                <person name="Neipel F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 158-1500</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Virus Res." volume="89" first="89" last="101">
            <title>Identification and characterization of the gene products of open reading frame U86/87 of human herpesvirus 6.</title>
            <authorList>
                <person name="Papanikolaou E."/>
                <person name="Kouvatsis V."/>
                <person name="Dimitriadis G."/>
                <person name="Inoue N."/>
                <person name="Arsenakis M."/>
            </authorList>
            <dbReference type="PubMed" id="12367753"/>
            <dbReference type="DOI" id="10.1016/S0168-1702(02)00126-0"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional transactivator.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with human UBE2I in the nucleus. Although this interaction does not promote IE2 sumoylation, it represses transactivation activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>Q77Z83-1</id>
            <name>1</name>
            <name>IE2 protein</name>
            <name>Protein U90-U86/87</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q69567-1</id>
            <name>2</name>
            <name>IE1 protein</name>
            <name>Protein U90-U89</name>
            <sequence type="external"/>
        </isoform>
        <isoform>
            <id>Q77Z83-2</id>
            <name>3</name>
            <name>IE-100</name>
            <sequence type="described" ref="VSP_034763"/>
        </isoform>
        <isoform>
            <id>Q77Z83-3</id>
            <name>4</name>
            <name>IE-55</name>
            <sequence type="described" ref="VSP_034764"/>
        </isoform>
    </comment>
    <comment type="domain">
        <text>The C-terminus binds to a DNA fragment that contains the transcription initiation site and an upstream sequence of the IEA promoter.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="CAA58335" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58335.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF015297">
        <property type="protein sequence ID" value="AAB67722.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF015298">
        <property type="protein sequence ID" value="AAB69858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T03824">
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D=1324-1500"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0025">Alternative splicing</keyword>
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    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
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            <begin position="516"/>
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            <begin position="1024"/>
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            <begin position="1041"/>
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            <begin position="1225"/>
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        <location>
            <begin position="1149"/>
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            <begin position="1484"/>
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</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q89544</accession>
    <name>DR5_HHV6U</name>
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            <fullName>Uncharacterized protein DR5</fullName>
        </recommendedName>
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    <gene>
        <name type="primary">DR5R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
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            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58325.1"/>
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    </dbReference>
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            <begin position="1"/>
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            <begin position="71"/>
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        <location>
            <begin position="80"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="145" mass="15636" checksum="4CE166D229786351" modified="1996-11-01" version="1">MRTRAGPSKQSRDNLGLRVDFSFFMPAYVGVLSRLCRRGRVCAGPSRARDRGCDGNCALLRFRNEGVRPIGARGRGRTYTKGGSSRSPASWAEQGRPPFTLSVSGTVLCLGRGLPAVRKAGFCRRVSVHGYVAFGTYGKGTYGEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-02-23" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q89565</accession>
    <accession>Q69579</accession>
    <accession>Q76QV1</accession>
    <name>DR8_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein DR8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DR8L</name>
        <name type="synonym">SJRF1</name>
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    <gene>
        <name type="primary">DR8R</name>
        <name type="synonym">SJRF1</name>
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    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
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        <lineage>
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            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
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            <taxon>Roseolovirus</taxon>
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    <organismHost>
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        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Oncogene" volume="9" first="1167" last="1175">
            <title>A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1.</title>
            <authorList>
                <person name="Thompson J."/>
                <person name="Choudhury S."/>
                <person name="Kashanchi F."/>
                <person name="Doniger J."/>
                <person name="Berneman Z."/>
                <person name="Frenkel N."/>
                <person name="Rosenthal L.J."/>
            </authorList>
            <dbReference type="PubMed" id="8134119"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="J. Gen. Virol." volume="76" first="451" last="458">
            <title>Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7844567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="sequence caution" evidence="2">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="CAA52025" version="1"/>
        </conflict>
    </comment>
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        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X79798">
        <property type="protein sequence ID" value="CAA56192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="S43068"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342568" description="Uncharacterized protein DR8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="110" mass="12765" checksum="8775C7A10035D218" modified="1996-11-01" version="1">MWRSSNQRGVSRRRDKSMRKYTRHGNADRRQRAIASMASVRKKKPRSKNTYTGNISSLPPRPNHRNIHLRNPLSPRFYHGRVHTQTHRHAQPTHVVVAGGYVDGAYRGET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q89584</accession>
    <name>DR6_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein DR6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DR6L</name>
    </gene>
    <gene>
        <name type="primary">DR6R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89584"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342566" description="Uncharacterized protein DR6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <sequence length="103" mass="12129" checksum="52529D2C17773200" modified="1996-11-01" version="1">MSTRHTQRTGGRISVRRNEARLAHARARARFDWLLLARGRPSKLYGYASRHRGELIHLPWPPCWCLELHHDPYRDARSATVWGHRWGWPATHVRPRCVQDCGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q89681</accession>
    <name>DR4_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein DR4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DR4L</name>
    </gene>
    <gene>
        <name type="primary">DR4R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89681"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342564" description="Uncharacterized protein DR4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="100" mass="10561" checksum="C14ABF1947008FE2" modified="1996-11-01" version="1">MRGTRRGPSGGWSPLGLALPRYPAGSVAASDPRSDTPPPRAPPPPPPLTTSAYRPHTHPAAESGARTRAEHARQHARHRPPEVTEPVHVPVLAGVCARVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q89698</accession>
    <accession>Q76QV0</accession>
    <name>U1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U1</name>
        <name type="synonym">SJRF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="J. Gen. Virol." volume="76" first="451" last="458">
            <title>Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7844567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X79798">
        <property type="protein sequence ID" value="CAA56194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89698"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342575" description="Uncharacterized protein U1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="123" mass="14337" checksum="717905887EDFC837" modified="1996-11-01" version="1">MAPAREGERERDGRQSRRGQTRIRRRRENGRGRSRGGPARAREGVERTRVETPRRAVDLSADIFADPRPVSLMQTRARTYTDTPTRPHRADCHVSENTHAREKKKQQQKNTHTQKNYTHGEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2021-06-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q89738</accession>
    <accession>Q76UF8</accession>
    <name>OX2V_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Putative OX-2 membrane glycoprotein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein U85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">U85</name>
        <name type="synonym">EDLF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042978.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89738"/>
    <dbReference type="DNASU" id="1487965"/>
    <dbReference type="GeneID" id="1487965"/>
    <dbReference type="KEGG" id="vg:1487965"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0393">Immunoglobulin domain</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000342560" description="Putative OX-2 membrane glycoprotein homolog">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="1">
        <location>
            <begin position="18"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="289"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like V-type">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like C2-type">
        <location>
            <begin position="146"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="290" mass="32900" checksum="3E93C7EAB2CB2C1D" modified="1996-11-01" version="1" precursor="true">MSSLMLRLLPLLYIISAHFVLHPETSPSLIYEIGSIVTFHCRLETTTNIRSVSWYNKNRLISNHEVQNMDNLSFTDDGYVLIHELNKINNLAVDSKLYFHIKHNRTTSLLKIKAKSAYDATCLTCTFTVDNEKTSATSCLKLFMKPIVVLYFRYLDNFLDVTCTVTSYPKPNVVIKFLGEVYKRDIPIVRQNENGSSTVSVNFTFKRRTKLEFVGKTVSCLASSWFTNQKASALVTSGEHTVQNHDEYSKEGVKSSNSDETVFTWTVPLILILISVIVLLISVCIVAFKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q89743</accession>
    <accession>Q69578</accession>
    <name>DR7_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein DR7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DR7L</name>
    </gene>
    <gene>
        <name type="primary">DR7R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Oncogene" volume="9" first="1167" last="1175">
            <title>A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1.</title>
            <authorList>
                <person name="Thompson J."/>
                <person name="Choudhury S."/>
                <person name="Kashanchi F."/>
                <person name="Doniger J."/>
                <person name="Berneman Z."/>
                <person name="Frenkel N."/>
                <person name="Rosenthal L.J."/>
            </authorList>
            <dbReference type="PubMed" id="8134119"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1994" name="Virology" volume="201" first="95" last="106">
            <title>Transcriptional activation of minimal HIV-1 promoter by ORF-1 protein expressed from the SalI-L fragment of human herpesvirus 6.</title>
            <authorList>
                <person name="Kashanchi F."/>
                <person name="Thompson J."/>
                <person name="Sadaie M.R."/>
                <person name="Doniger J."/>
                <person name="Duvall J."/>
                <person name="Brady J.N."/>
                <person name="Rosenthal L.J."/>
            </authorList>
            <dbReference type="PubMed" id="8178493"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1269"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1997" name="Oncogene" volume="14" first="359" last="367">
            <title>Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53.</title>
            <authorList>
                <person name="Kashanchi F."/>
                <person name="Araujo J."/>
                <person name="Doniger J."/>
                <person name="Muralidhar S."/>
                <person name="Hoch R."/>
                <person name="Khleif S."/>
                <person name="Mendelson E."/>
                <person name="Thompson J."/>
                <person name="Azumi N."/>
                <person name="Brady J.N."/>
                <person name="Luppi M."/>
                <person name="Torelli G."/>
                <person name="Rosenthal L.J."/>
            </authorList>
            <dbReference type="PubMed" id="9018122"/>
            <dbReference type="DOI" id="10.1038/sj.onc.1200840"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HUMAN P53</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 3">Involved in transactivation (Probable). Displays transforming activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with human p53 and inhibits p53-activated transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae US22 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="CAA52024" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="X73675">
        <property type="protein sequence ID" value="CAA52024.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S43067">
        <property type="entry name" value="S43067"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89743"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003360">
        <property type="entry name" value="US22-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02393">
        <property type="entry name" value="US22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-0553">Oncogene</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000342567" description="Uncharacterized protein DR7">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="8178493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9018122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="363" mass="40830" checksum="E665E1E8A3C4B714" modified="1996-11-01" version="1">MRHLPFHGMPLRVQMFCAFFIRSETTDKNKATPTITFMVSCCFVWVKRLFYRVGRIHHVQSLTYARPITALDSCLYVCCGYGEKLQPVGFVKSYVTNSQLDTLRVLLVGKDGAVYVHHMRAARLCRLASSTTEFTRRGLQRDAVTYEEDLELPDQRMCGTNARHLFDVIAAAADEHNLLTVGGLCQTHAGVSCNLLETVGDPWTAVPAARMTLTVPQVQYRLWPEARRDLRRHLYAGHPLGPWLVCGVLSRERETQKPSPPIRTTVGNVPTPGPREVEIAWVVLTLAGPLLAFWPDTGKICRLANSFSTLWKMGPRAMRGHWTYSAPGRHLPGDAWPLCEHVRPQWKASEEESVPGLDATEVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2020-08-12" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q89746</accession>
    <name>DR1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein DR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DR1L</name>
    </gene>
    <gene>
        <name type="primary">DR1R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89746"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342561" description="Uncharacterized protein DR1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <sequence length="97" mass="11677" checksum="620FCB6050F15531" modified="1996-11-01" version="1">MPLTVRAGHAPYRLPLSNYWWLLLGRHSLRHVHSYLRLHKGLRIPLPWPEQECLHLHPKPYKCLLRYPCITRQPHLLQGWPTKSSLCECHIHFHFFT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q89863</accession>
    <accession>Q76UF9</accession>
    <name>U78_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U78</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U78</name>
        <name type="synonym">EDLF5</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89863"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000342583" description="Uncharacterized protein U78">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="109" mass="12725" checksum="9D13DF8BEB3C90A3" modified="1996-11-01" version="1" precursor="true">MNMLAYFLYCRQLLLAVVLIEFPPRLCGNTLRFYSYHLPLSTCHISDSFYLTSRTTSNLLFCHLLYCHQKSHQKSHQKKTTGYLKLFSNTIENIKNMFNSSPYTLSTTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q89882</accession>
    <accession>Q76WP0</accession>
    <name>U95_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein U95</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U95</name>
        <name type="synonym">HCRF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1649" last="1660">
            <title>The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family.</title>
            <authorList>
                <person name="Thomson B.J."/>
                <person name="Honess R.W."/>
            </authorList>
            <dbReference type="PubMed" id="1321205"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the herpesviridae US22 family.</text>
    </comment>
    <dbReference type="EMBL" id="D11134">
        <property type="protein sequence ID" value="BAA01907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1631">
        <property type="entry name" value="JQ1631"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042988.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89882"/>
    <dbReference type="GeneID" id="1487971"/>
    <dbReference type="KEGG" id="vg:1487971"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342585" description="Uncharacterized protein U95">
        <location>
            <begin position="1"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="561"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="838"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="911"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="914"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; by host" evidence="1">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1121" mass="124067" checksum="F996BA4240FC6FE3" modified="1996-11-01" version="1">MSAHPDDLFWQQILNMDPTELLSDDVISSTCDENTAAGTDIMQPLCVDMSVQPTTSGCHTGAMMSDSYFSNDTPDQNCQSHSTLTDLSPEDMNNQINVQPNQMTFQPISPPIQDQNYGYSNNMINPIKPASIIKLHGHSIGEMTVTDPSSHVNAQHFVQQSNPKFFLNMYPCMTANSQGPGECQSVHNQSSGSGSNSYDINTAPRDEWIFTTSGGESWVLKRNTPNPPNSRTNLIFNNAQPIFHTQPQVSGFSDCSYQGGGLNSREYVNLAGYTPVCNMQNIKNSWATQLGASIDCMTASPTGIDANVNSAFQPVGVVSNNRGANVSMGGMGNYIENNSPWNQYYKSEMANNSINVKESNVYGHVGCVNDAISDKQGGTANVPSSLLNPDHQDWMRMTGTNTHMLNNINTNTEMENYDFPENDGNVHGATGVDLSTLSNGQQHSAFEGNGTFPVVNTGNPRTTLNCAPQLFLLGGNPTIAHPMNGNNETPDKNVCKPTPSTGVIKKLNFDGVDRGGGIGNFPKLASFVAMREKMSNTVNPSCGTFLEQLEGLRQQNSFEKNISFADLHFSEEDDVLSSASSVSCNSNCDMKIEVSQQGITVSNLQQGFRQQMNMNSSVVKMDGSYKTQEMSNGCATDVTDNAGTIQQNKRIHSQNENPEDGQVREGGCSDVRNEPPRKSARIHNMKSEGVTCGMCMTAADSTRQDASGGSSSGTKNEYYDDESELTGLSDTDSDNEVQCCQEVTKVGPKTYSSENFNPEYRQAKRLLADIPYRRWIPDPVNMEDNDGPFIPIVTRPATVCMNGRRRRTFFRQCVTAFGPLSKLTYFKELLQSYVSKNNNSYLSISWPPKHGVYVMSEKKLGYEHIPTLKDKFPLPCGWMMVLGVVGAEPPAALNKNMVILLCENRWVLLHNYSNSTHELFLAASDLKQFMEEGLSRCDPIYEESTVPYGVAMENSLRDFLRNSRTFQDLMDQRDNMHGCNWTFNGMPGRLGDRVIHLCNPESVDSIPGDEAVVCEGRPLYFFAYVTTFKSNPATKATVLIAADKDLRIYGYHKGRPRIRYLCKNVKTFFKAGARKFYLDFQITPKRLLAVNEEEYLNTLQNAPCLLLKPSVFRNIYSQEGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-02-23" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q89893</accession>
    <name>DR2_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein DR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DR2L</name>
    </gene>
    <gene>
        <name type="primary">DR2R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae US22 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89893"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000342562" description="Uncharacterized protein DR2">
        <location>
            <begin position="1"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="620" mass="67150" checksum="4A40EBD49B11D186" modified="1996-11-01" version="1">MIYCVLSTTPGTFWFPSGFDPKPYHPSADSKLLPLGLITLSACSTRVSATTRWSSFHATDPSLSWLTGSSPWLVILQGQGGSLFCHDVLQGRLYILSHSVSLFLKTGLRHCEAIYRAPLWRDRPLPSLWTCRDPDKAFLPTLLARSARRGLAAFYALWRLHLGSRSELSHPVLEWESTELVLTDWRRGRNEAQRDAPSVAEHFARCRPLLDELCGEGGWLPFAFLSTSPHVWLILTEGGPVLAVDVNDTSVWRIADDLELLRRLGSLLLLSGLRLPLRPPSGSGEAAGEPGYEEEERRGRASTASATAATSTRGPTRPTRVTRKGRVATGGVHLSARPESEEQTDGHHGRQESSDDHQRGGSGRGHRDDGAHRHANDKTEPQQRGEHEERKQTDSGRHEHAQESQVARRDEEETEQGDSERSCGGATQTYGGRGRHDSCPSIPLSVPGPDPRLWVPPPHLLFPSPLPPMTPVDDEPSVRPRCPPGPAEEPPTCRPRPPRPSSDTPLSAVSRPSAPPVPPPSTARVRFFLSSSSSSPSYSPAPLSPPSPVSPSSPRSPFIPPIRSPGLRAKPRVSSGHPAAFPPAPSSAPARSERVTSVPSSASPSASCVGKSQPPAAHTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-02-23" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>P24437</accession>
    <name>UL87_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U58</name>
        <name type="synonym">5R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Virol." volume="64" first="287" last="299">
            <title>Human herpesvirus 6 is closely related to human cytomegalovirus.</title>
            <authorList>
                <person name="Lawrence G.L."/>
                <person name="Chee M."/>
                <person name="Craxton M.A."/>
                <person name="Gompels U.A."/>
                <person name="Honess R.W."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2152817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae UL87 family.</text>
    </comment>
    <dbReference type="EMBL" id="M68963">
        <property type="protein sequence ID" value="AAA65568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F33560">
        <property type="entry name" value="F33560"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042951.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P24437"/>
    <dbReference type="DNASU" id="1487940"/>
    <dbReference type="GeneID" id="1487940"/>
    <dbReference type="KEGG" id="vg:1487940"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004285">
        <property type="entry name" value="Herpes_UL87_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007618">
        <property type="entry name" value="Herpes_UL87_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04532">
        <property type="entry name" value="DUF587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03043">
        <property type="entry name" value="Herpes_UL87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116227" description="Protein U58">
        <location>
            <begin position="1"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="772" mass="88747" checksum="3A20FDD10A7AC9F6" modified="1992-03-01" version="1">MQHTGNCETLIVNSCFGSTCARSIPVFIDSCDLTAEVSRDEETRLARSMPVVLEKIESIIEKIFQTSGPNIVHDKDRAKIALCRLLLGPVAVPCFCEEWDTNDYLSKSGCKCIGPILYIHTSRCRCSDIPVFKFSIMKDYYASHVFRGLLSLKEWNTHLPNVLCTCELSMSDRYVATVYPKQNSIYLEYYPYFLCYLCRHLTVIEIEQCTNDLISLLGPKVAQRVIIHFKLLFGFRHKPHIGTVDSWFWENFFMLELHKLWLTVVKHNRVTTDFFNVVYEKIQNYKQYAIKTLRMSSKAVPAIQRLCLAKFKQQLLYLNIKVTVKKNKREMCLNGFVYGKTLYVVESSQLIFRNLLLLYYDYSLPDECKTNEENVLTAHYIRVISRLSFKRSRSALPPGVRPDFIFVAQQPKRKELPNVPGGIDFAEITSVRHGAVTLNAFNTNKVMNLKATISKRANFVYHRIPKTMTHSFVMYKHTFKEPAFTVSTFVSNDDLDMSSLNINIRGPYCDFLYALGVYKMHVSIRDLFLPAFVCNSNNSVDLQGLENQDVVRNRKKKVYWITNFPCMISNANKVNVGWFKAGTGIIPRVSGEDLQNVLLQELNNVREIPGLVFDMDLHQLLVLLEQRNLHQIPFLVKQFLIFLRLGLLMGYGHSRRNKVHDIMLHLISNGLFDFNKNSVANTKIKHGCALVGTRLANNVPKIIARQKKMKLDHMGRNANSLAVLRFIVKSGEQKNKTVFIKLLEYLAETSTAINTRNEVARLLQTLTAKVKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-02-23" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>P52437</accession>
    <accession>Q69054</accession>
    <name>ITP_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inner tegument protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U30</name>
        <name type="synonym">P2RF1</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Virol." volume="68" first="597" last="610">
            <title>Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.</title>
            <authorList>
                <person name="Nicholas J."/>
                <person name="Martin M."/>
            </authorList>
            <dbReference type="PubMed" id="8289364"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via C-terminus) with the large tegument protein/LTP (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus</location>
            <location evidence="1">Host trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae inner tegument protein family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA16738" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="L25528">
        <property type="protein sequence ID" value="AAA16738.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T09325">
        <property type="entry name" value="T09325"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042923.2">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52437"/>
    <dbReference type="PRIDE" id="P52437"/>
    <dbReference type="GeneID" id="1487908"/>
    <dbReference type="KEGG" id="vg:1487908"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04043">
        <property type="entry name" value="HSV_ITP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007611">
        <property type="entry name" value="Herpes_U30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034738">
        <property type="entry name" value="HSV_ITP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04523">
        <property type="entry name" value="Herpes_U30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1040">Host Golgi apparatus</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-0920">Virion tegument</keyword>
    <feature type="chain" id="PRO_0000116048" description="Inner tegument protein">
        <location>
            <begin position="1"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with large tegument protein" evidence="1">
        <location>
            <begin position="604"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1082" mass="124058" checksum="C595695408F1A989" modified="1996-10-01" version="1">MTHDNRQLLPQETKLVTPNKDTLSSRYLHVLIIDNTLSTIEFVYMAVKAVLTQVDTLNALEQRKNRPTNRILGLSTSVSKRYINIPKFSSSGASNSQGVKTLAAIRKFCLPDKNCFRNFLSFSTTLFKVPSSIDIYFLFFTASTVSTMAARALDLEFILSSLKNSTSPESLLAATAKIELLSLAADSVTHNRVIAFINRLTPKKYHFDLIRQYAVFYFLNSTTLTSENKLLSAELLYEELSQIPSSSSSGTELENLNNAEVLYVFDRILNSIKMLKNELSSPIGKLRAQPAANDPGTDKTIKYSKIQSIIQKINSFTHENSLLANCRAVVELIDDLYRKLYSWFLHVLTFEDIQFPGDTFLDRLLKMDYCFTYYPSSNRHLIDLFEKTLDNQTFTNLDKFFDTSGNSPELLYQKTFSLKIFSKNLTAQDNGLYIYPLLKTDLSILDFLGTENILFHRGLIYHILHQKTIPQERENDLNKINQFFATVIQQVIETKSSCLPASLSQLLDTIFHFNRIGLNMETCRTYIEILSNHMATPDTQPIINTFTINLTHIVFTAHVFFICMENFSPTFIFYNRKKLILEQQRAILIIERNDYSTLWKQISDHIECLFNVSLSESFFKEYTKGGNEDQKQFLYKNLFEKWGNVFFPFTYSVSTSNNSTAHHITTLELRDICKEVYQSDSPDAYESLLPYSTHPSFKTLFVKIYVIPMVSHITNLTFDKLQSDCRLLTLIHACKLLLPSQHLLLHYMAWLYAFSINVDHIDLGTFTVIKSVIFKIADHINVMTHTIYSPETNLLVSILLNAYTNYLQKYVNPWIKQTITANFSLIQTYITFTKQCASILATKCNINLDNLFIYITIGTDKIVTTSFCSFIATCRNLVRQHEEFEKSLQTIQISEITLTGMLRNIITSVSSSKELLTNEALQKFIDTVQRISQHVNETYHSISVNLEKCKTSNDILIESLKKIIYIVDVLSSNAILNTSLASRCLEAANLAVSNNSFTILEIKKDAVAVFKPFITQLFESMKPTTSLHKKLMSTQKLTTDHIPFLDTFDDRYNLVRHVERQLNWYAAHAEAAQQDLITPLKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>P52441</accession>
    <name>UL49_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U33</name>
        <name type="synonym">XILF3</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae UL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042926.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52441"/>
    <dbReference type="DNASU" id="1487910"/>
    <dbReference type="GeneID" id="1487910"/>
    <dbReference type="KEGG" id="vg:1487910"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004339">
        <property type="entry name" value="UL49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03117">
        <property type="entry name" value="Herpes_UL49_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116204" description="Protein U33">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="470" mass="54700" checksum="2810B8A06F7EDB32" modified="1996-10-01" version="1">MFYLKKLLRQLLAPLCKHGSYTHLQLFVMGEACVPGKCVLTMFLTNKKFLNKEVTEKFYNEFFAIWLRCRPETRLITKRLFNKMVMTKGLFVLLAYLYFVYRQCKVLELLSLYKLKTIKWVDVETRFRVYPPYKLNKLLEMPSFSEINELHMFLFEQQLLLPIPTHVNLPCMRLFCLRDYEQTETVMLRYRQREHVLSFPSMLRKYALKSPAGNFMFTMAKALVENFCFSADRYLIPVEHNNLVPMVPSKPERGDFPKILTFALATSLKDGLATSVISLPVMCYCKTKCSRFILEESYICVICAKCGHCLNSGKEKLCSPQGFSLSSMFYFRDKQEKNLIYSMHTDVMYCSLCGSQQLVFERIYEMSEHCVLGMKVKTVSWKAVIGTNSACTILNDNVKFDVIVPCSCRSCYSTVHLYNVTVKKLLRLVSHGSDFQCQRCQHSFRETCLDLEDCVNICQGCQISQNVRCI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>P52456</accession>
    <name>CEP1_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytoplasmic envelopment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U75</name>
        <name type="synonym">HDLF2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Virion tegument</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae cytoplasmic envelopment protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042968.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="P52456"/>
    <dbReference type="DNASU" id="1487957"/>
    <dbReference type="GeneID" id="1487957"/>
    <dbReference type="KEGG" id="vg:1487957"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04038">
        <property type="entry name" value="HSV_CEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002600">
        <property type="entry name" value="Herpes_UL7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01677">
        <property type="entry name" value="Herpes_UL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1040">Host Golgi apparatus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-0920">Virion tegument</keyword>
    <feature type="chain" id="PRO_0000115918" description="Cytoplasmic envelopment protein 1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04038"/>
        </source>
    </evidence>
    <sequence length="249" mass="28761" checksum="F23EB88CECEDBCB8" modified="1996-10-01" version="1">MKSLKKLKELETSDVFNILHVRTILKVIKIDKCISLARHPLVNITVGDDGIWFHLEDGTMINGLEYKTICEKELGFQGFIGIIILDSEDTLQELRLNPFQFKRRLIHMKVDTPEEFMLCGLVFALENLPLKQSTLHKLIAKLVLFPALSPITKILFNTCDTLVCTLRHIFFNEHASEILHKVPLMIRLYNEMKNTHIEVLELYFNTKRSHNFINLSLESRQLQDSSLQVIQLATQFAQTFYSKNGDTSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>P52508</accession>
    <name>GL_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Envelope glycoprotein L</fullName>
            <shortName evidence="2">gL</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gL</name>
        <name type="synonym">EDLF3</name>
        <name type="synonym">U82</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1994" name="Virology" volume="204" first="738" last="750">
            <title>Nucleotide sequence analysis of a 21-kbp region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes.</title>
            <authorList>
                <person name="Nicholas J."/>
            </authorList>
            <dbReference type="PubMed" id="7941342"/>
            <dbReference type="DOI" id="10.1006/viro.1994.1589"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1993" name="J. Gen. Virol." volume="74" first="1847" last="1857">
            <title>Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein.</title>
            <authorList>
                <person name="Liu D.X."/>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lelliott C."/>
            </authorList>
            <dbReference type="PubMed" id="8397282"/>
        </citation>
        <scope>INTERACTION WITH GLYCOPROTEIN H</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH (By similarity). Part of a gH-gL-gO complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Virion membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host Golgi apparatus</location>
            <location evidence="2">Host trans-Golgi network</location>
        </subcellularLocation>
        <text evidence="2 3">gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs. Found in Golgi-like bodies of fibroblasts. In T-lymphocytes, found in the endoplasmic reticulum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the herpesviridae glycoprotein L family.</text>
    </comment>
    <dbReference type="EMBL" id="U13194">
        <property type="protein sequence ID" value="AAA68473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ2165">
        <property type="entry name" value="JQ2165"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042975.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="SMR" id="P52508"/>
    <dbReference type="PRIDE" id="P52508"/>
    <dbReference type="DNASU" id="1487962"/>
    <dbReference type="GeneID" id="1487962"/>
    <dbReference type="KEGG" id="vg:1487962"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044177">
        <property type="term" value="C:host cell Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019064">
        <property type="term" value="P:fusion of virus membrane with host plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04036">
        <property type="entry name" value="HSV_GL_betahv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002689">
        <property type="entry name" value="Cytomegalo_gL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01801">
        <property type="entry name" value="Cytomega_gL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1169">Fusion of virus membrane with host cell membrane</keyword>
    <keyword id="KW-1168">Fusion of virus membrane with host membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1032">Host cell membrane</keyword>
    <keyword id="KW-1040">Host Golgi apparatus</keyword>
    <keyword id="KW-1043">Host membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0261">Viral envelope protein</keyword>
    <keyword id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <keyword id="KW-1160">Virus entry into host cell</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000038268" description="Envelope glycoprotein L" evidence="2">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P52526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="8397282"/>
        </source>
    </evidence>
    <sequence length="250" mass="28962" checksum="224C80F4FD8031AA" modified="1996-10-01" version="1" precursor="true">MELLLFVMSLILLTFSKAIPLFNHNSFYFEKLDDCIAAVINCTKSEVPLLLEPIYQPPAYNEDVMSILLQPPTKKKPFSRIMVTDEFLSDFLLLQDNPEQLRTLFALIRDPESRDNWLNFFNGFQTCSPSVGITTCIRDNCRKYSPEKITYVNNFFVDNIAGLEFNISENTDSFYSNIGFLLYLENPAKGVTKIIRFPFNSLTLFDTILNCLKYFHLKTGVELDLLKHMETYNSKLPFRSSRPTILIRNT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q01350</accession>
    <name>VU3_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Protein U3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">U3</name>
        <name type="synonym">SHL2</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Gen. Virol." volume="73" first="1661" last="1671">
            <title>Identification of homologues to the human cytomegalovirus US22 gene family in human herpesvirus 6.</title>
            <authorList>
                <person name="Efstathiou S."/>
                <person name="Lawrence G.L."/>
                <person name="Brown C.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="1321206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the herpesviridae US22 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="D10082">
        <property type="protein sequence ID" value="BAA00977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ1648">
        <property type="entry name" value="JQ1648"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_042894.1">
        <property type="nucleotide sequence ID" value="NC_001664.2"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q01350"/>
    <dbReference type="DNASU" id="1487883"/>
    <dbReference type="GeneID" id="1487883"/>
    <dbReference type="KEGG" id="vg:1487883"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003360">
        <property type="entry name" value="US22-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02393">
        <property type="entry name" value="US22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000116305" description="Protein U3">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="373" mass="43699" checksum="684A02E7236D274E" modified="1994-06-01" version="1">METTKNRRVRFTGGLHEPAQDSTMCGNAELQSRERTKTRQRVYNESKRDLVDLLRVYTCLNSVRMFTFVNFGRRIPLAWPEGYQLVINNCRDENEYADEKLDELAGLVCCPERLVVLGYVKKRGGIGSEPCYWFSKGDIVVLLGGAGRVYAHTWLLPQQLCRVGDTIDDFLRKGLKRFYYAHQLVSSLQFVVEDPEVDGVRSCRDVLCFRDRHIGRSFALRWPKNETLLFHRRRDSFAFVMCDEARRRLAEMCFFGSFGYKYFGDEGRISLYVADDGQIFGFNDNDEDGRPRFVAEDFQQFRRIGVTQYYKSYVFRREQPEWALLPTCHLSRMFYQKTWRQADADVLFLIARNDERNKFPDAGTRSAVHDVVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q89660</accession>
    <name>DR3_HHV6U</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein DR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DR3L</name>
    </gene>
    <gene>
        <name type="primary">DR3R</name>
    </gene>
    <organism>
        <name type="scientific">Human herpesvirus 6A (strain Uganda-1102)</name>
        <name type="common">HHV-6 variant A</name>
        <name type="synonym">Human B lymphotropic virus</name>
        <dbReference type="NCBI Taxonomy" id="10370"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Roseolovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1995" name="Virology" volume="209" first="29" last="51">
            <title>The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.</title>
            <authorList>
                <person name="Gompels U.A."/>
                <person name="Nicholas J."/>
                <person name="Lawrence G."/>
                <person name="Jones M."/>
                <person name="Thomson B.J."/>
                <person name="Martin M.E."/>
                <person name="Efstathiou S."/>
                <person name="Craxton M."/>
                <person name="Macaulay H.A."/>
            </authorList>
            <dbReference type="PubMed" id="7747482"/>
            <dbReference type="DOI" id="10.1006/viro.1995.1228"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83413">
        <property type="protein sequence ID" value="CAA58421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q89660"/>
    <dbReference type="Proteomes" id="UP000009295">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000342563" description="Uncharacterized protein DR3">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="192" mass="19403" checksum="1335B3C2028C49B0" modified="1996-11-01" version="1" precursor="true">MSGVLSCVLRACACAGLCCWVCMGAICGGCQRWWRRRCARWGRVGPRVRSGDGARWVSRKCETERAPSAARSPACSPHFVLVSSSSSSSCSSACSSRPLSSPPSPRAASHAVCAAGGCDLPTHDADGDADEGTDVTLSERAGADEGAGGNAAGCPEDTRGFARSPGDLMGGMNGDLGDEGETGEGGDNGAGE</sequence>
</entry>
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</uniprot>