<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C5K4V1</accession>
    <name>C5K4V1_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G patch domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR010107</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG670562">
        <property type="protein sequence ID" value="EER20373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002788577.1">
        <property type="nucleotide sequence ID" value="XM_002788531.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER20373">
        <property type="protein sequence ID" value="EER20373"/>
        <property type="gene ID" value="Pmar_PMAR010107"/>
    </dbReference>
    <dbReference type="GeneID" id="9053925"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER20373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="194" mass="22053" checksum="60500005309213FE" modified="2009-07-28" version="1">MSRKYYERLVTSSGVTSKKFESNLGAKILGKFGWKTGDGLGAEGQGMTDCLQVKRREENEGLGRELEKKESSEWENWWADSYNAIAKKLASVATTSSGSEDSSDDSSEDEGEARTTAIKRADMQKGKLRRIMRQERAAAKEEEEADKKKDKHKSKKHHREETKIRKSKRAAVEEEEVPKKKHKKSKKSKRSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C5K582</accession>
    <name>C5K582_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPN-loop GTPase</fullName>
            <ecNumber evidence="4">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR010249</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="4"/>
    <dbReference type="EMBL" id="GG670562">
        <property type="protein sequence ID" value="EER20504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002788708.1">
        <property type="nucleotide sequence ID" value="XM_002788662.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER20504">
        <property type="protein sequence ID" value="EER20504"/>
        <property type="gene ID" value="Pmar_PMAR010249"/>
    </dbReference>
    <dbReference type="GeneID" id="9054052"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="PTHR21231:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER20504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="292" mass="31998" checksum="8FFA51320789B65E" modified="2009-07-28" version="1">MADNTSSASSSSAQPMDGIEKESNGHKPTVIVVIGMAGAGKSTFVHRLYLHLTAQEKRVYSVNLDPAVRNVPYPTNIDIRDTVKYKDVMKHFGLGPNGAIMTSLNLFATRFDQAMGLIDQRAPELDYVIVDTPGQIEVFNWSASGTIILDSLAMAYPTVTLFVLDTVRCTSPTTFMSNMLYVTSIMYKTKLPTVAVFNKCDVHPSDSCTRWMSDWESYIDAVRNDEQNGPDHGGGYMSSLMRSMAINISEFYENLAHASVSSLTGIGMGDCEAQIIAAAEEYEEWARGALGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C5K6D0</accession>
    <name>C5K6D0_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA helicase-1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Pmar_PMAR006743</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG670888">
        <property type="protein sequence ID" value="EER19851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002788055.1">
        <property type="nucleotide sequence ID" value="XM_002788009.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER19851">
        <property type="protein sequence ID" value="EER19851"/>
        <property type="gene ID" value="Pmar_PMAR006743"/>
    </dbReference>
    <dbReference type="GeneID" id="9058362"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="225"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="448"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="700"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EER19851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="731" mass="79936" checksum="7B359281C2C95224" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C5K6V4</accession>
    <name>C5K6V4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">Pmar_PMAR012233</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
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            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG670960">
        <property type="protein sequence ID" value="EER19789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002787993.1">
        <property type="nucleotide sequence ID" value="XM_002787947.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER19789">
        <property type="protein sequence ID" value="EER19789"/>
        <property type="gene ID" value="Pmar_PMAR012233"/>
    </dbReference>
    <dbReference type="GeneID" id="9058130"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00157"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EER19789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="296" mass="33717" checksum="B17D9BC1CC538558" modified="2009-07-28" version="1">MAVSTGVLNGESRSFPPALDERAAQYSMLNHVINNLAAPLVNVDEDVMWKVEILIAAVIIVSLSVVYLPDHGVFTKPFKAVWRVLLGVALCYSCFLLYLLINYNRDNAMWDSVLLDVFGCNALGVCLGMLVVRKLGLEEYHWGFSRGGCWSDHRKLLLFLFITIFVEVLDTTLFFIKYELWMPTSHWILVCRTFFWAFFGPPCTTELYKLLYGQLSTFPLYLAVGTIIQCLELGLCIKFGQGVFHESMPSNIRISWAVIWTIVIARVIHLRMEAARKPVNGESVHNERVESPEQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C5K7U5</accession>
    <name>C5K7U5_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR012612</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG671079">
        <property type="protein sequence ID" value="EER19630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002787834.1">
        <property type="nucleotide sequence ID" value="XM_002787788.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER19630">
        <property type="protein sequence ID" value="EER19630"/>
        <property type="gene ID" value="Pmar_PMAR012612"/>
    </dbReference>
    <dbReference type="GeneID" id="9057468"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="120"/>
            <end position="148"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="288"/>
        </location>
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            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="635"/>
        </location>
    </feature>
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        <location>
            <begin position="227"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER19630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="635" mass="67477" checksum="A846BD89B4255740" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C5K8A9</accession>
    <name>C5K8A9_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">eIF-3c_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR015857</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG671101">
        <property type="protein sequence ID" value="EER19297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002787501.1">
        <property type="nucleotide sequence ID" value="XM_002787455.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER19297">
        <property type="protein sequence ID" value="EER19297"/>
        <property type="gene ID" value="Pmar_PMAR015857"/>
    </dbReference>
    <dbReference type="GeneID" id="9039550"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EIF3C"/>
    </dbReference>
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        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="156"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER19297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="855" mass="95059" checksum="54F754064A698719" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C5K8F6</accession>
    <name>C5K8F6_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polypeptide N-acetylgalactosaminyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR028629</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG671131">
        <property type="protein sequence ID" value="EER19164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002787368.1">
        <property type="nucleotide sequence ID" value="XM_002787322.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER19164">
        <property type="protein sequence ID" value="EER19164"/>
        <property type="gene ID" value="Pmar_PMAR028629"/>
    </dbReference>
    <dbReference type="GeneID" id="9039403"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="441"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="612"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER19164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="872" mass="97510" checksum="0A2319C0556C9071" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C5K8W5</accession>
    <name>C5K8W5_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR008847</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG671228">
        <property type="protein sequence ID" value="EER19077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002787281.1">
        <property type="nucleotide sequence ID" value="XM_002787235.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER19077">
        <property type="protein sequence ID" value="EER19077"/>
        <property type="gene ID" value="Pmar_PMAR008847"/>
    </dbReference>
    <dbReference type="GeneID" id="9039283"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER19077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="203" mass="23145" checksum="F31A84C555D42DB5" modified="2009-07-28" version="1" fragment="single">ILYLRSNSISSQRVIPFLVGILFFTQGLSSWVYGLLIYKGYLKRRIAILIGAAILTIFFVLRIALFYSNRGIVENFRQDPSTPDKWIKNRDPTPWEFFMIFGLTILLGIGKAAYDSQIPAIVYHHFQLTEYHVIAVCNYKGYRSIGSTLVYGIDLWGVDKIGAIYSDQRVFPTTSVILLVIVVIAYLPSGGYWLKNSLPHRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>C5KBZ3</accession>
    <name>C5KBZ3_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR019907</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG671946">
        <property type="protein sequence ID" value="EER18024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002786228.1">
        <property type="nucleotide sequence ID" value="XM_002786182.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER18024">
        <property type="protein sequence ID" value="EER18024"/>
        <property type="gene ID" value="Pmar_PMAR019907"/>
    </dbReference>
    <dbReference type="GeneID" id="9048415"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER18024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="472" mass="51994" checksum="D2371DA464BFE287" modified="2009-07-28" version="1">MLARLSEVIPGRLRFFGPVELSMLCSGLMRLRYYNEKLLRRIADEVPHRLPVLEPSHIGQIIYAFSVLGFRDQMLYVDIADDVMRRIRDFTNPIELLQVIKALAKAEVMLPGLWECLVDAGTSQWEEIIRGDIPSVAVQYLAAVASIDGHLVARGYPSANTQDFASAMCTVLLEKGNQLDLSLAARAIGSLGKLHRYNEQVWSPLLENVMSNIDHLQPDQISQVSLGLSSAGRGHPMTTPLIAALSARAISIVDDYDVWCAANTMQGFAGLGKRDVKLFGALAKHLAKNDKLLEDATPQGLASVLHSMAKVMIKSDIFLYIMANLVISKISAFEGQALGMVLYAYGRLNCYNEALVRACIKQLRAIINDLNLVSIHMISDGLKALGALSEDIEALLKQRVEDLGHETTYGVIDFDDDAEDAFDIAGEEAEEDPLTDSVQQEVVAAVERARVRSRGIRGTDHPYDHCSTFEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C5KC25</accession>
    <name>C5KC25_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">10 transmembrane domain, possible aa transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR019938</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG671946">
        <property type="protein sequence ID" value="EER18056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002786260.1">
        <property type="nucleotide sequence ID" value="XM_002786214.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER18056">
        <property type="protein sequence ID" value="EER18056"/>
        <property type="gene ID" value="Pmar_PMAR019938"/>
    </dbReference>
    <dbReference type="GeneID" id="9048446"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="5">
        <location>
            <begin position="43"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER18056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="466" mass="50476" checksum="4BCD5E0C69049FAF" modified="2009-07-28" version="1">MNFARISACEAGLLSEEEFDQAFDRQLEYDQGKTKESWSRMEVKDVTYALVCTAIGAGVLSLPYAMAQSGLIIGTLILLGIGVLSSYSGELLIEASKRTETISYGALARATCGAWAEMMTSACIALTTWLVMGSYMIVMADMMVPVLEWIIPGITVFVGGYWAFRLWIQVLSLLVILPYCLRDNMSGFKWIAVLSIVAMLALTAAVVLLSVIRIIEQPVQWTSHVQSSETVSAVSVKYFSGTSSFIAISISSVSYLCHFNIPPIVAKEMRAPTKKRANEAIRWSMVSVAIMYVAFAVFGYIYAYDMPGGVSGDILLSFPSDSLVVNIVRVGLYLTLDLSYPLLVLPCYQSLQSLLGGLRGDANHRSGGIGSKLWSVAEILLLCITSLACAIAVPHIQVVFAFLGSTVCNIITFVLPPLFFVNSRPAGSTLWTKRNAAPVALFALGILLVVACTGVQIANIDQLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C5KCG5</accession>
    <name>C5KCG5_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Pmar_PMAR023758</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG671995">
        <property type="protein sequence ID" value="EER17828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002786032.1">
        <property type="nucleotide sequence ID" value="XM_002785986.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER17828">
        <property type="protein sequence ID" value="EER17828"/>
        <property type="gene ID" value="Pmar_PMAR023758"/>
    </dbReference>
    <dbReference type="GeneID" id="9087135"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="PTHR14094"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP72" evidence="7">
        <location>
            <begin position="524"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EER17828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="633" mass="69663" checksum="ADD5F44C39C413D1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C5KDG7</accession>
    <name>C5KDG7_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone deacetylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR025429</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG672080">
        <property type="protein sequence ID" value="EER17478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002785682.1">
        <property type="nucleotide sequence ID" value="XM_002785636.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER17478">
        <property type="protein sequence ID" value="EER17478"/>
        <property type="gene ID" value="Pmar_PMAR025429"/>
    </dbReference>
    <dbReference type="GeneID" id="9062704"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="540"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER17478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="719" mass="81101" checksum="6501675E8692109B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C5KDW9</accession>
    <name>C5KDW9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR022375</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG672124">
        <property type="protein sequence ID" value="EER17423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002785627.1">
        <property type="nucleotide sequence ID" value="XM_002785581.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER17423">
        <property type="protein sequence ID" value="EER17423"/>
        <property type="gene ID" value="Pmar_PMAR022375"/>
    </dbReference>
    <dbReference type="GeneID" id="9062553"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="214"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="422"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER17423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="541" mass="58100" checksum="80A3D84028B0C619" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>C5KGG5</accession>
    <name>C5KGG5_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR021120</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG672918">
        <property type="protein sequence ID" value="EER16520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002784724.1">
        <property type="nucleotide sequence ID" value="XM_002784678.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER16520">
        <property type="protein sequence ID" value="EER16520"/>
        <property type="gene ID" value="Pmar_PMAR021120"/>
    </dbReference>
    <dbReference type="GeneID" id="9063595"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER16520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="237" mass="26427" checksum="4A319C2BF8B34F04" modified="2009-07-28" version="1">MFSQMDVAAPPESNGCLTFRKCFEIGYSSALKEKQQFPLPFERNDNLSATRPDVSLNSAKSLAQRLTPSGGSIYSNHSHDRLHPRSLAQKHRSRSSHCLLSFTRKFAVPAVAASRSSPYVGYFLKHGKRPVEGDKVSNSQSTTVARMSTVAMGAAERFLSWMLLTPSGLPYAEMAKIHHRVHSRRQHTCTNSILKKSNSCKKAQRVSYSSETRKIYGIDSYVNGRLPPDAAFRGSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C5KGS4</accession>
    <name>C5KGS4_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Pmar_PMAR029474</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG673027">
        <property type="protein sequence ID" value="EER16342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002784546.1">
        <property type="nucleotide sequence ID" value="XM_002784500.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER16342">
        <property type="protein sequence ID" value="EER16342"/>
        <property type="gene ID" value="Pmar_PMAR029474"/>
    </dbReference>
    <dbReference type="GeneID" id="9063399"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="789"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EER16342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="928" mass="104273" checksum="7151C280D61AF1FA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-04-07" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5KGT5</accession>
    <name>C5KGT5_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Pmar_PMAR029484</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="GG673027">
        <property type="protein sequence ID" value="EER16352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002784556.1">
        <property type="nucleotide sequence ID" value="XM_002784510.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER16352">
        <property type="protein sequence ID" value="EER16352"/>
        <property type="gene ID" value="Pmar_PMAR029484"/>
    </dbReference>
    <dbReference type="GeneID" id="9063409"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="PTHR22914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EER16352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="690" mass="77232" checksum="07D75B23CF38223F" modified="2009-07-28" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C5KHF6</accession>
    <name>C5KHF6_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR003480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG673069">
        <property type="protein sequence ID" value="EER16018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002784222.1">
        <property type="nucleotide sequence ID" value="XM_002784176.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER16018">
        <property type="protein sequence ID" value="EER16018"/>
        <property type="gene ID" value="Pmar_PMAR003480"/>
    </dbReference>
    <dbReference type="GeneID" id="9061005"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER16018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="220" mass="25059" checksum="EEA7FD85631986C9" modified="2009-07-28" version="1">MADQTATNNQLESMRRAILHLQQENRLLKDQLHRTCSSSTASSAHGGNEPSDPPFDLRRRSLELLTELDTLEKQQQSTNDRLVNHRISGIKAILARHQSMDESDTVIHELAQRRSSIKNSSNGAEDDDDDDDDDDEKEEEDDVSGDHEEPRFDMRRLSSDLESEIQALRALSESTKDRLINQRLTSCEQVLARQQEIEDFVKNGHPKGCFLTKPIMNVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C5KHI4</accession>
    <name>C5KHI4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kelch repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR003510</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG673069">
        <property type="protein sequence ID" value="EER16046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002784250.1">
        <property type="nucleotide sequence ID" value="XM_002784204.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER16046">
        <property type="protein sequence ID" value="EER16046"/>
        <property type="gene ID" value="Pmar_PMAR003510"/>
    </dbReference>
    <dbReference type="GeneID" id="9061033"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER16046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="450" mass="49270" checksum="EB3396A086750FD0" modified="2009-07-28" version="1">MSPQRKKWLHQRVISCHPCGSTQCCRRKRVLNAVGSSLLDYTSVAAFATGWQRLPPGGFDGRSGHALTVCWDGNTVYLAGGLDSMSRSMSDVYCSVDSGRSWEHRALSAEWSPRMGHCMVSLRDDKALILLGGWDRNFNFKNDVWRSTDGGRTWTEVIPVDPNGSFPPRCNFACAILHSGRIVVCGGLGMNNVHLNDVWCSDDSGGSWQRLSACAPWEPRWAMGFTTINGGQSMIMVGGTTMTGFLSDVWRSDDGGVSWKEITLDGDFGPRGGMAVVQHNPSGMLVLCGGEITITQGIGEPSNDVDQCSSDVWISRDEGFSWIKASTTTSESCGCLPPLGVSQDGLPETIPRRWQARCLVRCVALHSDRLLLVGGELRSEKRVNDAWLCTGATDAVAANGQHQWLLRLGEYVSGDRPPLAKRRRSMAPTLPCLPFHLWIGNIMPYIMGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5KJ98</accession>
    <name>C5KJ98_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR018751</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG673601">
        <property type="protein sequence ID" value="EER15400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002783604.1">
        <property type="nucleotide sequence ID" value="XM_002783558.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER15400">
        <property type="protein sequence ID" value="EER15400"/>
        <property type="gene ID" value="Pmar_PMAR018751"/>
    </dbReference>
    <dbReference type="GeneID" id="9046143"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER15400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="407" mass="44290" checksum="63D66B7D226F7D74" modified="2009-07-28" version="1">MDNNGINDEDEYRPGGCYHRLSIQLHSIDSLLLLLQVLKTVSGNNKDTTQDASTILHIRASNDDDEAASSSAGGAGAGLYIATESLSKTVIAGGFFPAQLCREFDLKAFTFNHRLGRLQELPIQEFPAQFAIYASPLINALQMFRTPTLLRLLYDSTPIDLHDDNVEDDDDATLKLVIKDESLGSVAECQCIIHTLAINEDERIDASEVLEVLNDDDDLPSAKCDVLATEVLFAIGQELTLSPYLGSKSDIAQGAASSSSSVEANVSITSPSDTNIPALEIKAIDCAAADAAVVEVRLPYRPGVVDNIAIANPTWRDSVSTTLPLPGLLCLLRSPCMKKHLRTSLWIHATSHALSARWSIPDETSGRTSSLVAVKVSAVADHHHRHTHDDSNNEHHPTRLNNRSRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>C5KJM6</accession>
    <name>C5KJM6_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR001412</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG673606">
        <property type="protein sequence ID" value="EER15360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002783564.1">
        <property type="nucleotide sequence ID" value="XM_002783518.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER15360">
        <property type="protein sequence ID" value="EER15360"/>
        <property type="gene ID" value="Pmar_PMAR001412"/>
    </dbReference>
    <dbReference type="GeneID" id="9046088"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002952731" evidence="1">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER15360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="195" mass="20758" checksum="3A242F9608CB9BA9" modified="2009-07-28" version="1">MRTMLLLVLMCGFASLVGGSVRHVSAPQGCTGVRKPSSSQFCAVGTIDTDASKVNITIYIFDIDDPSKSVYFHIQLAANGSEPAGLNITGGGIAKVNIVQVVKGMLFVPIRLSAETVAGGRGHYDPSTGRWTADITVIADADFMVSGCLLSSRDVLETSFVAWTWASNLSCVLWKVTSTLGRSFARINIMSGFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C5KK63</accession>
    <name>C5KK63_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR023298</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG673688">
        <property type="protein sequence ID" value="EER14975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002783179.1">
        <property type="nucleotide sequence ID" value="XM_002783133.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER14975">
        <property type="protein sequence ID" value="EER14975"/>
        <property type="gene ID" value="Pmar_PMAR023298"/>
    </dbReference>
    <dbReference type="GeneID" id="9061859"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER14975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="256" mass="27286" checksum="40F7C981C9119728" modified="2009-07-28" version="1">MLSFTQVAKCFVPRVSVLGAFHRSFASYAGYKNILVDVDVQKGTALVTLNRPKSLNALCDDLMKELSSATNALDKDDAIHAIVITGAGEKAFAAGADIKEMNSRQTMAEVYKQNMLAFWQDLANVKKPVIAAVNGYALGGGCELAMMCDIALASEKAVFAQPEVTLGTIPGAGGSQRLTRVVGKSLAMELCLTGRHMPAEEALRRGLVSHVYASEELVLKALEMAEKIASSSAPAIAMTKEAVNRAYETTLAEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C5KKF6</accession>
    <name>C5KKF6_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Pmar_PMAR023394</name>
        <name evidence="8" type="ORF">Pmar_PMAR026280</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 50983</strain>
            <strain evidence="10">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG682187">
        <property type="protein sequence ID" value="EER03603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG673688">
        <property type="protein sequence ID" value="EER15068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771787.1">
        <property type="nucleotide sequence ID" value="XM_002771741.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002783272.1">
        <property type="nucleotide sequence ID" value="XM_002783226.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03603">
        <property type="protein sequence ID" value="EER03603"/>
        <property type="gene ID" value="Pmar_PMAR026280"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER15068">
        <property type="protein sequence ID" value="EER15068"/>
        <property type="gene ID" value="Pmar_PMAR023394"/>
    </dbReference>
    <dbReference type="GeneID" id="9047924"/>
    <dbReference type="GeneID" id="9061952"/>
    <dbReference type="OMA" id="SRIGWLR"/>
    <dbReference type="OrthoDB" id="1122174at2759"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EER03603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EER15068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="306" mass="32867" checksum="C7819990FD0D940C" modified="2009-07-28" version="1">MLDNGSTTGTPHQQSSQVSYQALTDTRVNNARQAFEDMNPAASRNAHEMFTSEMSDELLAKMADHNEPTASGNRYVKPMVFGGLDGISTMFALIAGSVGAQLTLAHMVAVGVGNLVAGAFGMGFGEYVSAKAETDVAVKEQNREQWEVENYPEGEISEMVQLYRTRGISKDDAITVATTLSKYKEFWIEHMMLTELGLFPVDAEDSAAASGFAMFCSFMIFGSVPLLSYLLLIMLIKDLPVAGAFAGTVCTSLLTLFVLGVVKSKVVSQNPLKGGMYMLLQGALSAAASYWLGDLIQRALDAAGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C5KKF8</accession>
    <name>C5KKF8_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Pmar_PMAR023396</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG673688">
        <property type="protein sequence ID" value="EER15070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002783274.1">
        <property type="nucleotide sequence ID" value="XM_002783228.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER15070">
        <property type="protein sequence ID" value="EER15070"/>
        <property type="gene ID" value="Pmar_PMAR023396"/>
    </dbReference>
    <dbReference type="GeneID" id="9061954"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="61"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="376"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="611"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EER15070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="837" mass="94725" checksum="A808281D484A3ADA" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>C5KPH8</accession>
    <name>C5KPH8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR001284</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG675112">
        <property type="protein sequence ID" value="EER13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002781812.1">
        <property type="nucleotide sequence ID" value="XM_002781766.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER13607">
        <property type="protein sequence ID" value="EER13607"/>
        <property type="gene ID" value="Pmar_PMAR001284"/>
    </dbReference>
    <dbReference type="GeneID" id="9042577"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="369" mass="41000" checksum="98A1840538D967D4" modified="2009-07-28" version="1">MFNEDHSIWWTRAYANDTTPLPDLCLALQGWSGVTAVTSGMPHEAREPLVAAIRSGLETAWVVDEVKESPDGVDLSLETLPWICFGSDGVQARQAVLGALVSLEKRVGYRLATSVRVADSRGLKPKLVFQKMPQEADRAEYVGLSFNQMDRVRLFGPPHQGLDQFLVSAISGAIAAGWPRGCSRQQECGEAEEWVLKGFPFDAFFKSRVDTRLLLSNILQVMWQQNFEIAGVVEGKLPVIYWRRSENASKDIRGPVNPVVSVMFNAPNKIRITSTDQRSLSPAIAAVREALQSPQVWKDVLKEDSLYGRSIEFKLDNWPFFRRPVGSNAVLSTSILLNVINAMASVGLTFKASLNLARHRSCMGSLFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C5KRU7</accession>
    <name>C5KRU7_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="2">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Pmar_PMAR018043</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="2"/>
    <dbReference type="EMBL" id="GG675931">
        <property type="protein sequence ID" value="EER12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002780993.1">
        <property type="nucleotide sequence ID" value="XM_002780947.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12788">
        <property type="protein sequence ID" value="EER12788"/>
        <property type="gene ID" value="Pmar_PMAR018043"/>
    </dbReference>
    <dbReference type="GeneID" id="9058985"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002097">
        <property type="term" value="P:tRNA wobble base modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="3">
        <location>
            <begin position="67"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EER12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="527" mass="58810" checksum="AC981993E78FE65B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C5KSB8</accession>
    <name>C5KSB8_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Pmar_PMAR025215</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="GG676011">
        <property type="protein sequence ID" value="EER12626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002780831.1">
        <property type="nucleotide sequence ID" value="XM_002780785.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12626">
        <property type="protein sequence ID" value="EER12626"/>
        <property type="gene ID" value="Pmar_PMAR025215"/>
    </dbReference>
    <dbReference type="GeneID" id="9058490"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HGTP_anticodon" evidence="3">
        <location>
            <begin position="117"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="ProRS-C_1" evidence="4">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EER12626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="296" mass="32905" checksum="C047ABEE05A50D26" modified="2009-07-28" version="1">MVYDILDVYKMLYEDLLAVPVVQGVKSEMEKFAGGEATTTCEAFVACNGRAVQGATSHFLGTHFAKMFGIEFEDRNGEKKFAEQTSWGFTTRSIGVMIMEHGDDKGLVLPPRVAEVQVVIVPIPPKGAGAQWSTAELKTMIGEKCKSLYEDLNANGVRVVLDDRDDKTPGYKFNHWELKGVPLRIEVGAKDLEKGVVTFVRRNTGKKSQEAEHSSVKVKEALESIQSELLETARAKLEDGIVKVTKWDEVMPALNARKLILAPWCETEESEEQMKKITAEESKEQIVVTDEEGGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C5KTM4</accession>
    <name>C5KTM4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-ketoacyl-CoA thiolase A, peroxisomal, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR016603</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG676169">
        <property type="protein sequence ID" value="EER12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002780408.1">
        <property type="nucleotide sequence ID" value="XM_002780362.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12203">
        <property type="protein sequence ID" value="EER12203"/>
        <property type="gene ID" value="Pmar_PMAR016603"/>
    </dbReference>
    <dbReference type="GeneID" id="9061280"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="293"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="416" mass="43529" checksum="9C934721D4D131EC" modified="2009-07-28" version="1">MERVAAVSTHVAGGQSNTYKDEKKPDDVVICAALRTPLCKAKRGSFRTTSVEDMMCPVMKAVVERTGVDPKTIGDVQMGNVLQSGSGVVPARMAALMAGIPIEVPTVSINRQCSSGLQAVANIASDIKAGYIKVGLAGGVESMSMYDMMSALDPSKVSDNVFEHEAARNCLIPMGMTSENVAAKFGITREVQDRMAVESHLKASRAQKDGLFDDEIVPVVTKIVDPKTGESKTITVTKDEGCKPETTFEGLSSLRPAFLKGGSTTAGNASQVTDGAACVLLARRDEAQRQGLPILARFQGFSAVGVPPEIMGIGPAAAIPAVLAQTGLKVADIDIYEINEAFASQATYCVHKLKIPAEKLNPKGGAIALGHPLGCTGARQIATLLPEMKRTKAKLGVVSMCIGGGMGAAGLIVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>C5KTX3</accession>
    <name>C5KTX3_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR019119</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG676180">
        <property type="protein sequence ID" value="EER12015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002780220.1">
        <property type="nucleotide sequence ID" value="XM_002780174.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12015">
        <property type="protein sequence ID" value="EER12015"/>
        <property type="gene ID" value="Pmar_PMAR019119"/>
    </dbReference>
    <dbReference type="GeneID" id="9060929"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER12015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="302" mass="33607" checksum="0E79B8C74135B699" modified="2009-07-28" version="1">MPNVGASPHPDDNNKHFTWEAKWKQYAPEKALLVSGSFGGPFVIFTLTPLRNGLTLASQDRVSTMASLYRRCFIHGFRSGWVGGLWPSIPAIPQFCVLGPMYHIYASFLGQKAALVCTAVTETAITYGANTRNAEVAYNHYVPRTDRLTNLTPAYKPIGPGAFMHATRNALGMCGMRVFAAPLDEHMRKVIRNPQASRMLSDFVASCLSGAISMPFNQLYNFFVTSKEARAATRLQRVSLATTYLKGQYLTVAPDGSVRPSRIMLRDMGMRCLYAGTLFCIYATIERNLVENWSFLSERFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5KU22</accession>
    <name>C5KU22_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosine kinase</fullName>
            <ecNumber evidence="4">2.7.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR019169</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4"/>
    <dbReference type="EMBL" id="GG676180">
        <property type="protein sequence ID" value="EER12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002780269.1">
        <property type="nucleotide sequence ID" value="XM_002780223.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12064">
        <property type="protein sequence ID" value="EER12064"/>
        <property type="gene ID" value="Pmar_PMAR019169"/>
    </dbReference>
    <dbReference type="GeneID" id="9060975"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="PTHR45769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="79"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="245"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="418" mass="45520" checksum="3AEA869C477DDA52" modified="2009-07-28" version="1">MSGSVLDEESSSSSLFASCPLGGVESFSVVSYDHPILDLVATVDDAHGFGLKANTQRLTDGSDEDKKLFARMLGDGELTVHRIAGGQAMNSLRGVKWWFDRHEADPEYNDVSFANTSVRIVGSVGDDEYANVLREACVEAGLETDFEVFPGGRTGKCCALLKDKKRTMITDLGVAPDFRAGPERGIPTDCRILYTTAFYACGDGYACREYIPNHPQIKSGYTKLFAGLSAAWACKNDDFTYMARYACDVVFGNEVEFTAFAEHLGIVGVSKMSPREIAEAVSAFMKPGAWAIMTQGPDPVVCCSNLTDTCDAFTHTVRDLDPLAISDDIGAGDGFVGGFIAAIYARLLASDFTPRSVPSPVESIISNARDDDTSYLLPGDDSRSDTWYWITRQMVMDGVEEGIYCARQVMKHTGCQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C5KU95</accession>
    <name>C5KU95_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cisplatin resistance-associated overexpressed protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR019243</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG676180">
        <property type="protein sequence ID" value="EER12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002780342.1">
        <property type="nucleotide sequence ID" value="XM_002780296.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12137">
        <property type="protein sequence ID" value="EER12137"/>
        <property type="gene ID" value="Pmar_PMAR019243"/>
    </dbReference>
    <dbReference type="GeneID" id="9061124"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="PTHR12375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="307" mass="36078" checksum="DD8AC6B0E3942823" modified="2009-07-28" version="1">MVAAHDGCLSPNELFVNTRAYMGSCGKEHCEYTKFRFDQMEDGREKREIIDRYERKLLSYCEYMETQLAQKIRRGKARVATEIPDIEVPAQNREKIDELRVKINSLVKEAESLAERGRLVDSERKMSLIEPLNDKIRDLSGEKYLHMTRTEFVCDVCGCLVTLNENDSRITLENHEHARGKQHQGWAKIKETSKALREKFASGRGLPLSPSTRETPRVERTPIERRSPPRSETKKVEESPKKETSNGPEVDERKSEEYQSKVEDWRTHLSKMRSKKPKHRHHREKDCHHRRHRSRSRDKRDRSGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C5KUA8</accession>
    <name>C5KUA8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mucolipin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR019256</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG676180">
        <property type="protein sequence ID" value="EER12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002780355.1">
        <property type="nucleotide sequence ID" value="XM_002780309.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12150">
        <property type="protein sequence ID" value="EER12150"/>
        <property type="gene ID" value="Pmar_PMAR019256"/>
    </dbReference>
    <dbReference type="GeneID" id="9061136"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="PTHR12127"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans" evidence="5">
        <location>
            <begin position="304"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="510" mass="58402" checksum="3D17EF4D60B7FDD7" modified="2009-07-28" version="1">MASASSSRCLRCLQTADQDYIDRDPHRAPLMSPRERVTLNPCEKFRRHGLWPWRLTVHVCLALLTTAMVCIWTENDCLHARHALRHFYTGFIGVSGNPGERERYASSPSELASICNNTLEHYWHIDRKSLSDFRHLSQPPVLHILWLNGDQQRMVLDDAWEEDPAYGHFINSVDRLKRIRDMHFVIHILDPFPGSWWWQCLSWNIRVHFDYGGSGQIKSRLSFDLTECSDGELRALFLEDPHLAEERYTHPALYLLPFFCLPLTLLSAALTIRSHALRRGGGSLRSTGDSNDILLRELAVGWLDPWLIFVLLANAVQTLAALQCIQKADKTADVYWRLSLLGVGAGMAWLTLLRYLKFFPTYYVLIRTLARAFPRLLRFLSGLVPLLLAYALCGTCVFWPSSNFASLSDALMGMFSLLNGDIIHDMFMDMTSISWFWGQVYCYTFLCLFIYVVLNIFLAIVDEAFCTAKRFEELHLRPSESSSTAGSSTSIRNVDDTGGIKCSWRTLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C5KUS5</accession>
    <name>C5KUS5_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiolproteinase SmTP1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR013077</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG676319">
        <property type="protein sequence ID" value="EER11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002780001.1">
        <property type="nucleotide sequence ID" value="XM_002779955.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER11796">
        <property type="protein sequence ID" value="EER11796"/>
        <property type="gene ID" value="Pmar_PMAR013077"/>
    </dbReference>
    <dbReference type="GeneID" id="9060365"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER11796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="254" mass="27142" checksum="C600D980F8263AD2" modified="2009-07-28" version="1">MTRLGTMPKDRSFTGNEANTVGYEGSVEELPAAVNYVAKGWVTGVKDQGVCGSCWAFSTTGALEALHKNLTGDLVPLSEEQLLDCSLSYGTQGCQGGWMSNAFEYVADHGIDSEKDYPYKSKFIPIFFPIHLPCQHNHTAVIAPHSTRYVNVTSSKPALLAAIALSGPVSVAIDAGSRAFQHYGGGVLNSPCNTTLNHGVLAVGYDLEAIEPYYLVKNSWGARWGDKGYIKMAIDDSPKGICGILLAASYPISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C5KV05</accession>
    <name>C5KV05_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UTP15_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR002322</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG676384">
        <property type="protein sequence ID" value="EER11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779925.1">
        <property type="nucleotide sequence ID" value="XM_002779879.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER11720">
        <property type="protein sequence ID" value="EER11720"/>
        <property type="gene ID" value="Pmar_PMAR002322"/>
    </dbReference>
    <dbReference type="GeneID" id="9047143"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="416"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="UTP15_C" evidence="6">
        <location>
            <begin position="660"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="767" mass="83206" checksum="2575E7EAC9AFEFA0" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C5KX81</accession>
    <name>C5KX81_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Pmar_PMAR021417</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG677119">
        <property type="protein sequence ID" value="EER10938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779143.1">
        <property type="nucleotide sequence ID" value="XM_002779097.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10938">
        <property type="protein sequence ID" value="EER10938"/>
        <property type="gene ID" value="Pmar_PMAR021417"/>
    </dbReference>
    <dbReference type="GeneID" id="9055972"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SSF50044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="78"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EER10938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="145" mass="15810" checksum="349185B8E3DA0FAB" modified="2009-07-28" version="1">MMDVLVDYHSSTNSHHSALNKRMHGCSASEVVTAREATPLTRQTERSCRSSLEGSANSSDRVCRERNDGVARLSSCSSEGPLCISLGNFLARHNSSEVALRPGDEVTILDAGEGWSEIYVHRTGERGFAPSAFLMLHPFTHQSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C5KXF8</accession>
    <name>C5KXF8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Structural maintenance of chromosome 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR000716</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG677256">
        <property type="protein sequence ID" value="EER10682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002778887.1">
        <property type="nucleotide sequence ID" value="XM_002778841.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10682">
        <property type="protein sequence ID" value="EER10682"/>
        <property type="gene ID" value="Pmar_PMAR000716"/>
    </dbReference>
    <dbReference type="GeneID" id="9038917"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="819"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="921"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER10682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="1259" mass="139156" checksum="3A95DD322AE14455" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C5KXM8</accession>
    <name>C5KXM8_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Pmar_PMAR000797</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="GG677256">
        <property type="protein sequence ID" value="EER10752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002778957.1">
        <property type="nucleotide sequence ID" value="XM_002778911.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10752">
        <property type="protein sequence ID" value="EER10752"/>
        <property type="gene ID" value="Pmar_PMAR000797"/>
    </dbReference>
    <dbReference type="GeneID" id="9039062"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="9">
        <location>
            <begin position="73"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EER10752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="258" mass="28315" checksum="1DE29B3E794D02E6" modified="2009-07-28" version="1">MTLLAPEVCCQKQELGSEAADISRPARDGTPDDDASLHLTDEDSATKTGRSSASIPESSYSSSTKSGSSTSSIESAARRILESIDGEDADRQGLQKTPMRYAKALEFLTKGYSESLEEIVNDAVFDVEPSDNDEMVMVRDIDMFSLCEHHLLPFYGTVDIGYIPRGKVLGLSKLARITEMFSRRLQVQERMTQQIARAVEEAINPMGVAVVIRASHMCMSMRGIQKTSASTTTSCVLGAFRSNPKTRAEFFSLISHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C5KXU8</accession>
    <name>C5KXU8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prp4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR000866</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG677256">
        <property type="protein sequence ID" value="EER10822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779027.1">
        <property type="nucleotide sequence ID" value="XM_002778981.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10822">
        <property type="protein sequence ID" value="EER10822"/>
        <property type="gene ID" value="Pmar_PMAR000866"/>
    </dbReference>
    <dbReference type="GeneID" id="9039205"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="239"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER10822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="587" mass="66623" checksum="4C8042946AB4D8A6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C5KXV2</accession>
    <name>C5KXV2_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR000870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG677256">
        <property type="protein sequence ID" value="EER10826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779031.1">
        <property type="nucleotide sequence ID" value="XM_002778985.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10826">
        <property type="protein sequence ID" value="EER10826"/>
        <property type="gene ID" value="Pmar_PMAR000870"/>
    </dbReference>
    <dbReference type="GeneID" id="9039209"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER10826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="621" mass="66243" checksum="7BBBF143818EF3A5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C5KXV3</accession>
    <name>C5KXV3_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR000870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG677256">
        <property type="protein sequence ID" value="EER10828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779033.1">
        <property type="nucleotide sequence ID" value="XM_002778987.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10828">
        <property type="protein sequence ID" value="EER10828"/>
        <property type="gene ID" value="Pmar_PMAR000870"/>
    </dbReference>
    <dbReference type="GeneID" id="9039209"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER10828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="622" mass="66330" checksum="D7554582555FE751" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C5KY17</accession>
    <name>C5KY17_PERM5</name>
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        <recommendedName>
            <fullName evidence="4">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Pmar_PMAR019002</name>
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    <organism evidence="6">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
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            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG677298">
        <property type="protein sequence ID" value="EER10624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002778829.1">
        <property type="nucleotide sequence ID" value="XM_002778783.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10624">
        <property type="protein sequence ID" value="EER10624"/>
        <property type="gene ID" value="Pmar_PMAR019002"/>
    </dbReference>
    <dbReference type="GeneID" id="9038765"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="SSF57889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="471"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EER10624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="916" mass="97494" checksum="68DC783282DD4C8A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>C5KY20</accession>
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        <submittedName>
            <fullName evidence="10">Copper-transporting ATPase P-type, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">Pmar_PMAR019004</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
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        <property type="protein sequence ID" value="EER10627.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002778786.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10627">
        <property type="protein sequence ID" value="EER10627"/>
        <property type="gene ID" value="Pmar_PMAR019004"/>
    </dbReference>
    <dbReference type="GeneID" id="9038767"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
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    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="92"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EER10627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="965" mass="101734" checksum="CADA02A41246269E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C5KYA0</accession>
    <name>C5KYA0_PERM5</name>
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        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily C member 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR005811</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG677382">
        <property type="protein sequence ID" value="EER10477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002778682.1">
        <property type="nucleotide sequence ID" value="XM_002778636.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10477">
        <property type="protein sequence ID" value="EER10477"/>
        <property type="gene ID" value="Pmar_PMAR005811"/>
    </dbReference>
    <dbReference type="GeneID" id="9038435"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="258"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER10477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="550" mass="62110" checksum="4B519D8F39F2B6D5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>C5L0V2</accession>
    <name>C5L0V2_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein PMS1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR008733</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG678140">
        <property type="protein sequence ID" value="EER09593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777798.1">
        <property type="nucleotide sequence ID" value="XM_002777752.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER09593">
        <property type="protein sequence ID" value="EER09593"/>
        <property type="gene ID" value="Pmar_PMAR008733"/>
    </dbReference>
    <dbReference type="GeneID" id="9052518"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="5">
        <location>
            <begin position="230"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="4">
        <location>
            <begin position="694"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER09593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="871" mass="94986" checksum="34AB8F2E9C36FE48" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C5L163</accession>
    <name>C5L163_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Pmar_PMAR016402</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678232">
        <property type="protein sequence ID" value="EER09470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777654.1">
        <property type="nucleotide sequence ID" value="XM_002777608.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER09470">
        <property type="protein sequence ID" value="EER09470"/>
        <property type="gene ID" value="Pmar_PMAR016402"/>
    </dbReference>
    <dbReference type="GeneID" id="9052368"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="172"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="432"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EER09470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="512" mass="57519" checksum="2AE326CBE6225E28" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C5L1G7</accession>
    <name>C5L1G7_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein farnesyltransferase subunit beta</fullName>
            <ecNumber evidence="3">2.5.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CAAX farnesyltransferase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ras proteins prenyltransferase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Pmar_PMAR025946</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="3"/>
    <dbReference type="EMBL" id="GG678316">
        <property type="protein sequence ID" value="EER09394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777578.1">
        <property type="nucleotide sequence ID" value="XM_002777532.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER09394">
        <property type="protein sequence ID" value="EER09394"/>
        <property type="gene ID" value="Pmar_PMAR025946"/>
    </dbReference>
    <dbReference type="GeneID" id="9052315"/>
    <dbReference type="OMA" id="WCIYWIL"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018343">
        <property type="term" value="P:protein farnesylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="PTHR11774"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PTHR11774:SF6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EER09394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="366" mass="41348" checksum="1E551CDFDDB584F1" modified="2009-07-28" version="1">MNDDRFPTHSSMEQRRTEMSIMNCYEGFMKEQADGSAATDEKAFQLNREAHTKFLKKALKSLPTKYSCLDASRPWFVFWILRALELLGELDRLEVAEDVNFQGVYFFSEQSLDIGRFXXFLISMKDRSTGGFRVHENGETDMRGCYCAIAVAKMMKLLTPELEEGVVGYIRRCQTWEGGLAGEPGLEAHGGYGFCGLAAATMLGKAEEALNLERLARWVCQRQLAFEGGFNGRPNKLVDSCYSYWQYGSLSILKALLDIPEKEQAWCAPEPLQMYILLACQDRERGGFRDKPGKNCDYYHTCYALSGMAASQWHCGSPPVTLGDNTTLVQSDVLYNISKEALSRLEKYFEDIPTITHKECFSTCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>C5L1W5</accession>
    <name>C5L1W5_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR024217</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678486">
        <property type="protein sequence ID" value="EER09281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777465.1">
        <property type="nucleotide sequence ID" value="XM_002777419.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER09281">
        <property type="protein sequence ID" value="EER09281"/>
        <property type="gene ID" value="Pmar_PMAR024217"/>
    </dbReference>
    <dbReference type="GeneID" id="9065624"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER09281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="202" mass="22510" checksum="0CB7BBDC1950D5C6" modified="2009-07-28" version="1">MLGMSSPMRASWGAPRSCSVVRGGPLNLTNSELQRYETAEILDWCLRDFALSALCSSSTVRRGGIPLVLNVHCVDTIHLLREEYAYRVILIENKEVAVDHGLPFIDLSCEASARAEISTPRVLFVGGGELEGVGPLIPKIPTVFDHHHSYNVCTAMTLVMFERYRFTKTWPRPSMLPPLSDGELAALREQRVGTRGKDHDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C5L216</accession>
    <name>C5L216_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Pmar_PMAR009705</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678492">
        <property type="protein sequence ID" value="EER09209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777393.1">
        <property type="nucleotide sequence ID" value="XM_002777347.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER09209">
        <property type="protein sequence ID" value="EER09209"/>
        <property type="gene ID" value="Pmar_PMAR009705"/>
    </dbReference>
    <dbReference type="GeneID" id="9065473"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="148"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="336"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EER09209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="515" mass="56721" checksum="3C2C4A99D4D2B63D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C5L2P0</accession>
    <name>C5L2P0_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR009947</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678662">
        <property type="protein sequence ID" value="EER08955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777139.1">
        <property type="nucleotide sequence ID" value="XM_002777093.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER08955">
        <property type="protein sequence ID" value="EER08955"/>
        <property type="gene ID" value="Pmar_PMAR009947"/>
    </dbReference>
    <dbReference type="GeneID" id="9064865"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER08955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="835" mass="92927" checksum="F11FF6B64791C34E" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C5L2P5</accession>
    <name>C5L2P5_PERM5</name>
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            <fullName evidence="5">Utp13 domain-containing protein</fullName>
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        <name evidence="6" type="ORF">Pmar_PMAR009951</name>
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        <lineage>
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            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="EER08960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_002777098.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER08960">
        <property type="protein sequence ID" value="EER08960"/>
        <property type="gene ID" value="Pmar_PMAR009951"/>
    </dbReference>
    <dbReference type="GeneID" id="9064869"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
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    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
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    </dbReference>
    <dbReference type="Pfam" id="PF08625">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
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            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
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        </location>
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    </feature>
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            <end position="873"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER08960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="909" mass="98652" checksum="D015DF55AE42DF5D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>C5L3K2</accession>
    <name>C5L3K2_PERM5</name>
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        <submittedName>
            <fullName evidence="7">Zinc transport protein, putative</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">Pmar_PMAR017634</name>
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    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
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            <taxon>Perkinsidae</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="EnsemblProtists" id="EER08580">
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        <property type="gene ID" value="Pmar_PMAR017634"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="26"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EER08580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="300" mass="32255" checksum="8F2C376EBF99E6B1" modified="2009-07-28" version="1">MSSDLDLWKGLAIAINVVVCFIGILLSRWISQTKLYEISCALVAGVLLATGLVHLLSDSVESLANLTELMNGYPFPYMLCGIMFIILLMIEQSVDVYQVKRKEESPKLFKGDASHTHPHDIESQSSQISTSSQLTSADDDASKDMHHHDVNMSEASAIFIFLALSVHSIFEGLSLGASNNASQIASTLIAIAIHKGLAAYALGASFIEAKVSKWRMVIFSVIFAFMTPAGIAIGWGLEAAESDTEVLSGVCSALAAGTFLYVGALEFVPMSFKPGSSYIIWKFVALLVGYGAMSALAIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="40" xmlns="http://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">Pmar_PMAR017641</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
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                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678922">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblProtists" id="EER08589">
        <property type="protein sequence ID" value="EER08589"/>
        <property type="gene ID" value="Pmar_PMAR017641"/>
    </dbReference>
    <dbReference type="GeneID" id="9042199"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rab-GTPase_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47923"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="533"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER08589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="790" mass="90379" checksum="0EC665F7758823FC" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>C5L4C7</accession>
    <name>C5L4C7_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR000403</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG679081">
        <property type="protein sequence ID" value="EER08363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002776547.1">
        <property type="nucleotide sequence ID" value="XM_002776501.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER08363">
        <property type="protein sequence ID" value="EER08363"/>
        <property type="gene ID" value="Pmar_PMAR000403"/>
    </dbReference>
    <dbReference type="GeneID" id="9041228"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER08363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="263" mass="29902" checksum="4E0D8EF407E1D2E5" modified="2009-07-28" version="1">MPTKNPGPSRTTTSSSSCKLHSYCRLRFWLTFALVPILSILFYGIAAFYVSSRPLNAEGVKNAVDQARQVCRLDGTKPTCREDKRYELEMNRVYPSEYGLASLQQHKARNVFNECPRGHYLVPVSESDAGRGFFRQSLYVDPEDDCRLWELEPVRTSLFHDPYELLKMTSLNPDCSSAEIEVNADAMLDSGVIQVNNQSRLGSFNYMDPWISPIQHFTYDVLPCALYAISKEPETVPRRTCVSSVYRQQQEGGELTMQEILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C5L582</accession>
    <name>C5L582_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exportin-2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Pmar_PMAR014904</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG679213">
        <property type="protein sequence ID" value="EER08141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002776325.1">
        <property type="nucleotide sequence ID" value="XM_002776279.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER08141">
        <property type="protein sequence ID" value="EER08141"/>
        <property type="gene ID" value="Pmar_PMAR014904"/>
    </dbReference>
    <dbReference type="GeneID" id="9064303"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EER08141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="933" mass="104171" checksum="DC3A3618049F72E5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C5L6Q3</accession>
    <name>C5L6Q3_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR003193</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG679811">
        <property type="protein sequence ID" value="EER07589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002775773.1">
        <property type="nucleotide sequence ID" value="XM_002775727.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER07589">
        <property type="protein sequence ID" value="EER07589"/>
        <property type="gene ID" value="Pmar_PMAR003193"/>
    </dbReference>
    <dbReference type="GeneID" id="9042066"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER07589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="328" mass="36300" checksum="2EA4029E0B918F11" modified="2009-07-28" version="1">MVFIIPTLEPSSAASIVTEYACKTLLHSDALSGTLVSRVLVLDASSPHWHIQHVRCFYRVKHLPALLVLDKEGNTVLEACGESDILQIESLRAIQEEYNNLRLSQNTQLEEKADSYQEAWKWVNSQGFNLLCFDVDGTITTSNINTTLAVGVTEFISNIRPGTRVALVTNQGGVGLRYWMESGHFGKPGNLPDEAKTRLSKIRDQLLEINPSLAIRIFVAYRYQSKADPSSGKSANWGPCPVESARDERWSKEWRKPNPGMLQAAMQWAGASRLGTLMVGDMQSDKDAAEGAGVIFRWAPEFFIKGIELPQIADVGTIVDEKFSSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C5L7A9</accession>
    <name>C5L7A9_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Pmar_PMAR020536</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="GG679899">
        <property type="protein sequence ID" value="EER07371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002775555.1">
        <property type="nucleotide sequence ID" value="XM_002775509.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER07371">
        <property type="protein sequence ID" value="EER07371"/>
        <property type="gene ID" value="Pmar_PMAR020536"/>
    </dbReference>
    <dbReference type="GeneID" id="9060216"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="PTHR45673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="SSF49562"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="305"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EER07371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="1122" mass="123377" checksum="27BDA55F70FE0113" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C5L867</accession>
    <name>C5L867_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Pmar_PMAR003947</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="GG680048">
        <property type="protein sequence ID" value="EER07093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002775277.1">
        <property type="nucleotide sequence ID" value="XM_002775231.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER07093">
        <property type="protein sequence ID" value="EER07093"/>
        <property type="gene ID" value="Pmar_PMAR003947"/>
    </dbReference>
    <dbReference type="GeneID" id="9059553"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017066">
        <property type="entry name" value="E3ligase_BOI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="PTHR22996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036836">
        <property type="entry name" value="RNase_bind_SBP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EER07093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="278" mass="30010" checksum="302FD5CBA9A121DC" modified="2009-07-28" version="1">MGQQESRTLPPLPQQHVIRLNPDGTSTEVVLNPAGSAMDTSNASHCSRTTPVANGEQLTPVAVQAYVDRASFRVGDGKVLFTLICSADAMVTVYMNAMNKYNSASSSRGRRRLQWPVLSYEHSQSKRVSCTAPNTRTTLEFDLEPSTVMLKAMSEQHWPLIIEVFVAATQSSTLMYLSPTDSHATNVTVSEQIHKLPNGTVVATGALYGLADITKNGDGKTRDTCSICLTNPINTALLPCGHTALCSDCARLLQQDPVNSKCPICRARVISSVTLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5L974</accession>
    <name>C5L974_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR007438</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680370">
        <property type="protein sequence ID" value="EER06722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002774906.1">
        <property type="nucleotide sequence ID" value="XM_002774860.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER06722">
        <property type="protein sequence ID" value="EER06722"/>
        <property type="gene ID" value="Pmar_PMAR007438"/>
    </dbReference>
    <dbReference type="GeneID" id="9056580"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER06722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="298" mass="31483" checksum="BBF9F1B05D530FD6" modified="2009-07-28" version="1">MPSDLRFSNEVPVADADANGGEGSSRGRGSTQGERRMTVGSGSSPLVQVDEYPAPSLFSAASNLIPEQNADIYALSSNTVDSSSYSPTTGSAPSHPSPTQHLLLQHAMGLTVDILVTYGVSSAGIDLLRSHGLVTVSDLAALDTRSLAQQGFTRADVDTLTRLAVEVGQESTNERLGQMQEELRNGNGIGEDHFLPIKNTFINFPPSQLPSSKKTPQSCPVDMGMTPPNSLNSSVGKVNSLSPVASSHSPDSFPINLDPSIYPSIGSRLHASGTCKPCAWFYHASGCRHGAQCEFCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5LC17</accession>
    <name>C5LC17_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR011525</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680918">
        <property type="protein sequence ID" value="EER05500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773684.1">
        <property type="nucleotide sequence ID" value="XM_002773638.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05500">
        <property type="protein sequence ID" value="EER05500"/>
        <property type="gene ID" value="Pmar_PMAR011525"/>
    </dbReference>
    <dbReference type="GeneID" id="9042023"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER05500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="164" mass="18266" checksum="463BA4B3299DBDCB" modified="2009-07-28" version="1">MSLVDTGGVQLEEISNEGVTEETDPMKNTPSIGEQPTDEPSVETVATNCAKALASLKGRREGQRLEKEARPTLIERESKLQDSGNEDNTKNVTDNTRTRSSSSSLDSAHGVWTPRHSPEEVRRMQSVLQQQWHLLWMVDSMNQHQVAAREVQSSATNVIKITRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5LC26</accession>
    <name>C5LC26_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosine kinase</fullName>
            <ecNumber evidence="4">2.7.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR011533</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4"/>
    <dbReference type="EMBL" id="GG680918">
        <property type="protein sequence ID" value="EER05509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773693.1">
        <property type="nucleotide sequence ID" value="XM_002773647.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05509">
        <property type="protein sequence ID" value="EER05509"/>
        <property type="gene ID" value="Pmar_PMAR011533"/>
    </dbReference>
    <dbReference type="GeneID" id="9042031"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="PTHR45769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="92"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="258"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER05509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="431" mass="46594" checksum="93AD748E99F83760" modified="2009-07-28" version="1">MADSVVVIEDEDELSSFSTTAASLVSNTCVSCPLGAAESFSVVSYDHPILDLVATVDDANGFGLKVNTQRLTDGSDEDKKLFARMLGDGELTVHRIAGGQAMNSLRGVKWWFDRHEADPEYNDLSFANTSVRIVGSVGDDEYANVLREACAEAGLETDFEVFPGGRTGKCCALLKDKKRTMITDLGVAPDFRAGPDRGIPADCRVLYTTAFYACGDGYACREYIPNHPQITSGYTKLFAGLSAAWACRNDDFTYMAQHACDVVFGNEVEFTAFAEHLGIAGISKMSPREIAEAVSAFMKPGAWAIMTQGPDPVICCSNLTDTCDAFAHTVRDLDPLAISDDIGAGDGFVGGFIAAIYARLLARDLTPRSIPSPLESSVSSISDDDVSEVLPYEGDRANAWHSITRQMIMDGVEEGIYCARQVMKHTGCQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5LCD8</accession>
    <name>C5LCD8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR011652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680918">
        <property type="protein sequence ID" value="EER05623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773807.1">
        <property type="nucleotide sequence ID" value="XM_002773761.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05623">
        <property type="protein sequence ID" value="EER05623"/>
        <property type="gene ID" value="Pmar_PMAR011652"/>
    </dbReference>
    <dbReference type="GeneID" id="9042599"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER05623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="268" mass="27813" checksum="27AAA585C6F6D045" modified="2009-07-28" version="1">MCKYRSPSSLAGSSSVISASHSGSNNSGKHGTRNTCEVPGCGRVPRKSSNSSRARFCTRHGGGRPCQYPGCQVAARGLLGFCYRHRHYANSSAYGNGVDGKVMPSPTPEATEDEVRASRLETYVPVPSCVDSAELTALTYIASTLKASQAAASTTDDDNTTTAGSNASPLATPTSSHSISSSQSPILTSGQRALIETPTSLVTTTSRATEAAFAAHSSAACDIDELFSIPTIPFTICKPALAAACGPLGEAPCPMDIQREEAVMARCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5LCD9</accession>
    <name>C5LCD9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR011652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680918">
        <property type="protein sequence ID" value="EER05621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773805.1">
        <property type="nucleotide sequence ID" value="XM_002773759.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05621">
        <property type="protein sequence ID" value="EER05621"/>
        <property type="gene ID" value="Pmar_PMAR011652"/>
    </dbReference>
    <dbReference type="GeneID" id="9042599"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER05621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="282" mass="29247" checksum="54CCE06D77743A4F" modified="2009-07-28" version="1">MCKYRSPSSLAGSSSVISASHSGSNNSGKHGTRNTCEVPGCGRVPRKSSNSSRARFCTRHGGGRPCQYPGCQVAARGLLGFCYRHRHYANSSAYGNGVDGKVMPSPTPEATEDEVRASRLETYVPVPSCVDSAELTALTYIASTLKASQAAASTTDDDSEPCNAATTLMAIEDTTTAGSNASPLATPTSSHSISSSQSPILTSGQRALIETPTSLVTTTSRATEAAFAAHSSAACDIDELFSIPTIPFTICKPALAAACGPLGEAPCPMDIQREEAVMARCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C5LCS5</accession>
    <name>C5LCS5_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR011805</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680918">
        <property type="protein sequence ID" value="EER05758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773942.1">
        <property type="nucleotide sequence ID" value="XM_002773896.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05758">
        <property type="protein sequence ID" value="EER05758"/>
        <property type="gene ID" value="Pmar_PMAR011805"/>
    </dbReference>
    <dbReference type="GeneID" id="9042960"/>
    <dbReference type="OMA" id="FVENREN"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="213"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER05758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="542" mass="58678" checksum="DAE047F7746BF5D6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C5LD11</accession>
    <name>C5LD11_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Pmar_PMAR029518</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG680950">
        <property type="protein sequence ID" value="EER05355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773539.1">
        <property type="nucleotide sequence ID" value="XM_002773493.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05355">
        <property type="protein sequence ID" value="EER05355"/>
        <property type="gene ID" value="Pmar_PMAR029518"/>
    </dbReference>
    <dbReference type="GeneID" id="9041381"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EER05355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="315" mass="33093" checksum="B06160E35DA3E281" modified="2009-07-28" version="1">MPYVPRYTIASPIFARLSRRGPCWTARSIAIGVGEAAFCSLAPVVIDDASPAGRKSSYLGFFFMSIYVGIALGNIVTSGVTSWAGGKTIFLVEACLMIPVIVLCVRWQWRFSTNAHQYTELNASTTSLIGDIKQVLMSRPFVLICLGSAAFNFVAGGLAVHGPTILRESLQASQAVATLGLGLATVFTGVVGTYFGGWLSDKVAGKDPSATTRARSGSKISSVMSAIGALSIALTATAKSTWAFLFMMSVALLASFATTAPSNVGLMSTVPEDVRSQGLAISIGVSHLIGDFPSPVIIGMYSLCSLPLLLVFQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C5LD43</accession>
    <name>C5LD43_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR029565</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680950">
        <property type="protein sequence ID" value="EER05387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773571.1">
        <property type="nucleotide sequence ID" value="XM_002773525.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05387">
        <property type="protein sequence ID" value="EER05387"/>
        <property type="gene ID" value="Pmar_PMAR029565"/>
    </dbReference>
    <dbReference type="GeneID" id="9041412"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="113"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER05387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="709" mass="77419" checksum="6A3F8387318D5138" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C5LDD0</accession>
    <name>C5LDD0_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Pmar_PMAR027903</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="GG680969">
        <property type="protein sequence ID" value="EER05263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773447.1">
        <property type="nucleotide sequence ID" value="XM_002773401.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05263">
        <property type="protein sequence ID" value="EER05263"/>
        <property type="gene ID" value="Pmar_PMAR027903"/>
    </dbReference>
    <dbReference type="GeneID" id="9050829"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="9">
        <location>
            <begin position="73"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EER05263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="258" mass="28370" checksum="FF75E87642056C71" modified="2009-07-28" version="1">MTSLAPEVCRQKQEVGGEAADISRPTRDGTPDDDASLHLTDEDSATKTGRSSASIPESSYTSSTKSGSSTSSIESAARRILESIDGEDADRQGLQKTPMRYARALEFLTKGYSESLEEIVNDAVFDVEPSDNDEMVMVRDIDMFSLCEHHLLPFYGTVDIGYIPRGKVLGLSKLARITEMFSRRLQVQERMTQQIARAVEEAINPMGVAVVIRASHMCMSMRGIQKTSASTTTSCVLGAFRSNPKTRAEFFSLISHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C5LF64</accession>
    <name>C5LF64_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR019682</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG681416">
        <property type="protein sequence ID" value="EER04648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002772832.1">
        <property type="nucleotide sequence ID" value="XM_002772786.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER04648">
        <property type="protein sequence ID" value="EER04648"/>
        <property type="gene ID" value="Pmar_PMAR019682"/>
    </dbReference>
    <dbReference type="GeneID" id="9037700"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="GBP" evidence="2">
        <location>
            <begin position="13"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER04648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="752" mass="84922" checksum="2BF52EBCF31CA133" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>C5LHM4</accession>
    <name>C5LHM4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR011364</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682131">
        <property type="protein sequence ID" value="EER03768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771952.1">
        <property type="nucleotide sequence ID" value="XM_002771906.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03768">
        <property type="protein sequence ID" value="EER03768"/>
        <property type="gene ID" value="Pmar_PMAR011364"/>
    </dbReference>
    <dbReference type="GeneID" id="9048351"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER03768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="209" mass="23428" checksum="B03553923AEE854B" modified="2009-07-28" version="1">MSSASRVHVWIQPLNDPTQIKPEWRRGLTFGVNTMALVCWAVASHINFCALAITLNGKDIDKKDISLWSAMTILYKNHPIALPVLGVFVWALPALESLLWVAVCAAPSLAVRVCAGVTMHIPIGRSCWGLASWLRQLRFWLMWDVATVSIIVMNSALNSTDKLRCEIYWLPYSLWWIATVLMYGGRSVGDDYLKLVISTVQGMPILAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C5LIN8</accession>
    <name>C5LIN8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Srpk, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR014658</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682243">
        <property type="protein sequence ID" value="EER03440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771624.1">
        <property type="nucleotide sequence ID" value="XM_002771578.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03440">
        <property type="protein sequence ID" value="EER03440"/>
        <property type="gene ID" value="Pmar_PMAR014658"/>
    </dbReference>
    <dbReference type="GeneID" id="9047602"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER03440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="803" mass="89319" checksum="3EAF94571588AF26" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C5LJQ5</accession>
    <name>C5LJQ5_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Pmar_PMAR001816</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682469">
        <property type="protein sequence ID" value="EER03071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771255.1">
        <property type="nucleotide sequence ID" value="XM_002771209.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03071">
        <property type="protein sequence ID" value="EER03071"/>
        <property type="gene ID" value="Pmar_PMAR001816"/>
    </dbReference>
    <dbReference type="GeneID" id="9051737"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EER03071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="772" mass="84419" checksum="AADAAAAE3E2D27C6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C5LK29</accession>
    <name>C5LK29_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiolproteinase SmTP1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Pmar_PMAR000910</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG682711">
        <property type="protein sequence ID" value="EER02918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771102.1">
        <property type="nucleotide sequence ID" value="XM_002771056.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER02918">
        <property type="protein sequence ID" value="EER02918"/>
        <property type="gene ID" value="Pmar_PMAR000910"/>
    </dbReference>
    <dbReference type="GeneID" id="9051400"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018618525" evidence="2">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor_I29" evidence="4">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="117"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EER02918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="289" mass="31792" checksum="5572BEEE1C166A93" modified="2009-07-28" version="1">MFLVVVTLQLIAVGHGASVEVEKAFQEFMRTYDKRYDTDEQYQVAKDAFENTMREIETLRANSNVTHEVGLNEYADLPKEVFNDILKCDFAPKLHTPMIRATAIPTVPQDSFEVGDYPPSVDWEAAGALAPVRRQSGDVKKCGSCYAIGAAVVMESRFKIELSQPRVVPFSVQQLVDCSTTYGNRGCDGGRAQEAFAYSKAEGIVKESSYQYMFEEGPCKESVVKNPDDQCIRPGDIVHLASIPKANEEAMLNAVARGPVAVTLYGAPAFDNYKDGIMRGSPTGLSHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5LL21</accession>
    <name>C5LL21_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR005925</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG683038">
        <property type="protein sequence ID" value="EER02585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002769867.1">
        <property type="nucleotide sequence ID" value="XM_002769821.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER02585">
        <property type="protein sequence ID" value="EER02585"/>
        <property type="gene ID" value="Pmar_PMAR005925"/>
    </dbReference>
    <dbReference type="GeneID" id="9047811"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER02585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="383" mass="43786" checksum="D822548065878098" modified="2009-07-28" version="1">MTAILVSYYTTDEDEEEEKDQANEDEEDGVGSRHHYHYQTGLRMSPIVGSSHTTQTNLLLVYISHNNNNNITMLHHQLLELMIIRFGPPGMELAYLRGNAQLNTGVQDRKGKFIFNNNNNNKNNATPNDEMLLSNPCTRFLGNKVYSSIQHPRRNLTLTSSRKETSNNNNNKSSDHTYNNNDDDPRKIIEDGLLQMMDIDICDNNLSVLHPMAIDRIVHTLDTRVHLLHNIIQELLRFSGGKETAVAALVGYRKGRLLIQRLCTALQYVLLPPHDDDAQCSCSSSDAGNDVLNNDNTNSHHHDHHHHGVGDSMMIMRGRGRTLSLLQNKDEVTHRQEHRIQTLLSTIEDTIRWEHLTYPCYNMLTILSSMLHCITRQENVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C5LLT4</accession>
    <name>C5LLT4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR006628</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG683299">
        <property type="protein sequence ID" value="EER02306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002769588.1">
        <property type="nucleotide sequence ID" value="XM_002769542.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER02306">
        <property type="protein sequence ID" value="EER02306"/>
        <property type="gene ID" value="Pmar_PMAR006628"/>
    </dbReference>
    <dbReference type="GeneID" id="9055374"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000079">
        <property type="term" value="P:regulation of cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="entry name" value="PTHR15615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER02306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="203" mass="22940" checksum="798BA5881D40C8C7" modified="2009-07-28" version="1">MEDKLSLKRAAATRRRNGGGRMDGFLQAMSNLLEHMVLVASLERADCPGTPTRFHGVSPPTISIYHYLQRVEAHFRCSSECFVIALIYIHRLLKTQGPNFVVSMCAIHRVILTAVVLAAKFFDDRYYSNRFYAAVGGVRTKELNALEADFLRLINWNLHTSPQEYESYRMSVWSSVEPTMLPLSSSPPPPEMLINLIKVAYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C5LNN0</accession>
    <name>C5LNN0_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone deacetylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR008230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG683822">
        <property type="protein sequence ID" value="EER01651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002768933.1">
        <property type="nucleotide sequence ID" value="XM_002768887.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER01651">
        <property type="protein sequence ID" value="EER01651"/>
        <property type="gene ID" value="Pmar_PMAR008230"/>
    </dbReference>
    <dbReference type="GeneID" id="9040202"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="488"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER01651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="850" mass="95397" checksum="3CABDB115FE81180" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>C5LNN2</accession>
    <name>C5LNN2_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone deacetylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR008230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG683822">
        <property type="protein sequence ID" value="EER01650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002768932.1">
        <property type="nucleotide sequence ID" value="XM_002768886.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER01650">
        <property type="protein sequence ID" value="EER01650"/>
        <property type="gene ID" value="Pmar_PMAR008230"/>
    </dbReference>
    <dbReference type="GeneID" id="9040202"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="442"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER01650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="804" mass="90177" checksum="A113CF8403A56C7B" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C5LPE7</accession>
    <name>C5LPE7_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Pmar_PMAR027537</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG684111">
        <property type="protein sequence ID" value="EER01409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002768691.1">
        <property type="nucleotide sequence ID" value="XM_002768645.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER01409">
        <property type="protein sequence ID" value="EER01409"/>
        <property type="gene ID" value="Pmar_PMAR027537"/>
    </dbReference>
    <dbReference type="GeneID" id="9039892"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="203"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EER01409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="338" mass="37628" checksum="C477B81976D715B1" modified="2009-07-28" version="1">MPALLTFSSIRLAPPLLPLLPPLIKVGQMIAPFLAKIAAKGALGKYIIASKTKILIGSKWTAKALPLARAYSIKQKANGNRHEEYHFWIFDKSVAILSVLTASLTTLIILGSLERNPFNERWRLLHLSITEERELGEKAAEEILEQCLANDARAVLASDHPLTREVVRIVESLNRELPQLLDDYLKSSGASPHTWEESKELIPHWKVHLILSDTCNATCLPSGDIFIYAGCIARCGTRDRLAAIIAHEIAHVISRHGAEQISAAAIMDVPLGYFSSFATLSMTAFGIFRYLLMWHRPPTSWIVDLPYSRHCEHEADVLGMELMSRAGYDPRAAVSEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C5LR51</accession>
    <name>C5LR51_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR003007</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG684654">
        <property type="protein sequence ID" value="EER00936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002768218.1">
        <property type="nucleotide sequence ID" value="XM_002768172.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER00936">
        <property type="protein sequence ID" value="EER00936"/>
        <property type="gene ID" value="Pmar_PMAR003007"/>
    </dbReference>
    <dbReference type="GeneID" id="9057260"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER00936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="1358" mass="152835" checksum="BDC256F99DB9B7A6" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C5LR76</accession>
    <name>C5LR76_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR003031</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG684654">
        <property type="protein sequence ID" value="EER00961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002768243.1">
        <property type="nucleotide sequence ID" value="XM_002768197.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER00961">
        <property type="protein sequence ID" value="EER00961"/>
        <property type="gene ID" value="Pmar_PMAR003031"/>
    </dbReference>
    <dbReference type="GeneID" id="9057284"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PTHR23248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER00961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="203" mass="22202" checksum="6DAAAD6FBAF8B328" modified="2009-07-28" version="1">MQYPNPQIQPPGQVQMATVIGNPMPVGRPTTVLDGMQIVAGLQKVQVRELRQMVEAITGFDQRNKYIVKDEAGRDIFYAVEESNVCERNCYPADCAPWDLHIYVLGPNGLRGDLIHWLTVHRPCSCTCLCANRPVAYVTETSTDQLLGTLHDPYACCDLTFKIKDAAGNDVITGVGGCCQLGMCCPLPCGPCQHVGVELTDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C5LR78</accession>
    <name>C5LR78_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR003032</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG684654">
        <property type="protein sequence ID" value="EER00963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002768245.1">
        <property type="nucleotide sequence ID" value="XM_002768199.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER00963">
        <property type="protein sequence ID" value="EER00963"/>
        <property type="gene ID" value="Pmar_PMAR003032"/>
    </dbReference>
    <dbReference type="GeneID" id="9057285"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER00963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="235" mass="25485" checksum="C788A9F49EFE6DE6" modified="2009-07-28" version="1">MLFPLLSETPKRALKFSTNAQLRDSFQRLGYSGQTLALMSGVGAGICEGAIVCSPELVKIRMQLPENRGLYSSSIQAASAIIRHEGVAALFTGFWCTLLRNACWNGTYFGSIFAIKSTIYSTTKEESKFLNFAAGTIAGSLGCCVNTPLDVVKTRMQNSSALKQARPEDAERLLAVPTRTVPLLLHVARTEGVSSLWKGLAPKIIRLGPGGGIMLVVYEQVTDYLGRLERRAGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>C5LRW0</accession>
    <name>C5LRW0_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR011222</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG684987">
        <property type="protein sequence ID" value="EER00537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002767819.1">
        <property type="nucleotide sequence ID" value="XM_002767773.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER00537">
        <property type="protein sequence ID" value="EER00537"/>
        <property type="gene ID" value="Pmar_PMAR011222"/>
    </dbReference>
    <dbReference type="GeneID" id="9043611"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER00537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="132" mass="14235" checksum="829B65677B33758C" modified="2009-07-28" version="1">MVNLRSCSYYYILMSDMDGLVGNTNLPYYGKPTGCTCSGEKFVGSCECPNKQDLFALTGGYSTCYAICAKPCAQASDCPPAPKSASVHIKCVLGRCLLDCSGYDDICAKEDGSVCFRYRMGPAKGTMCSWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C5LRZ5</accession>
    <name>C5LRZ5_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR018350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG685006">
        <property type="protein sequence ID" value="EER00467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002767749.1">
        <property type="nucleotide sequence ID" value="XM_002767703.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER00467">
        <property type="protein sequence ID" value="EER00467"/>
        <property type="gene ID" value="Pmar_PMAR018350"/>
    </dbReference>
    <dbReference type="GeneID" id="9043541"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER00467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="193" mass="21694" checksum="3F7BB8996FD93DF3" modified="2009-07-28" version="1">MSPSLRQLLLPLLRRKEYSLLSGFTVCTLASPLPGPILSWSSCLPKCVVKELSEAEFEGENCLEKISGRSPWKLSILASGEQLCAFIVYKFVNERRAFSVAKLAVPKTMRGKGLGTFVMKWVKESCKSNPNVDLVTLSSLPAAIKLYKKIGFRKIYTITQSDPEEELVEGQVYMEMNVRKPGQARHRASHRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C5LT08</accession>
    <name>C5LT08_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Replication factor a 1, rfa1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Pmar_PMAR014811</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG685284">
        <property type="protein sequence ID" value="EER00145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002767427.1">
        <property type="nucleotide sequence ID" value="XM_002767381.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER00145">
        <property type="protein sequence ID" value="EER00145"/>
        <property type="gene ID" value="Pmar_PMAR014811"/>
    </dbReference>
    <dbReference type="GeneID" id="9049843"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23273">
        <property type="entry name" value="PTHR23273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rep-A_N" evidence="8">
        <location>
            <begin position="12"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="7">
        <location>
            <begin position="325"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="REPA_OB_2" evidence="9">
        <location>
            <begin position="433"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EER00145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="577" mass="62277" checksum="7A0899718ADA6D34" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5LT37</accession>
    <name>C5LT37_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR024482</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG685288">
        <property type="protein sequence ID" value="EER00004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002767286.1">
        <property type="nucleotide sequence ID" value="XM_002767240.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER00004">
        <property type="protein sequence ID" value="EER00004"/>
        <property type="gene ID" value="Pmar_PMAR024482"/>
    </dbReference>
    <dbReference type="GeneID" id="9049701"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER00004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="167" mass="18215" checksum="18741E0CE263CD3E" modified="2009-07-28" version="1">MLVTSRQAEHHIDTNLRVGKFHLGADPRNIEDTDGSTTTSSTSRTNHIKNFGLPPPSKIEHSECEWDHGGFGPTSLPEISGVVVDMNAKCVPKSADSMSLKDLRAALQASHKRMMAIVEEERELNMDGSAFTGATTTNGLCQQLESSEGYVRLRQWAERSGFGISGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C5LT52</accession>
    <name>C5LT52_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR024496</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG685288">
        <property type="protein sequence ID" value="EER00020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002767302.1">
        <property type="nucleotide sequence ID" value="XM_002767256.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER00020">
        <property type="protein sequence ID" value="EER00020"/>
        <property type="gene ID" value="Pmar_PMAR024496"/>
    </dbReference>
    <dbReference type="GeneID" id="9049715"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="PTHR15002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER00020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="256" mass="28681" checksum="2954D53541AE2A31" modified="2009-07-28" version="1">MAFAGLPGKTLPWADWREWLRCYQGLSGQSVEGKLEAVKMVDLWRIRGRVPIAVDCTGMVLQVMCHDPYFCPETTAQVSLDELQQLYSLVVIRLCNGVIDTEQKGQVAQSQDSIARRIGFPTWLVELRHEATHGSSLPTIHVLRMAAESILRYLDTNYWSRQYAQLDAEGVFTATEPDTDYVEARLPRGTFEGKCLLLRKKLAALGHGVGVTEAVKFFIYLLNKVASNDDVRDMFLNVAHNVSPATEKGIHCCPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>C5LUC7</accession>
    <name>C5LUC7_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR010923</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG685476">
        <property type="protein sequence ID" value="EEQ99659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766942.1">
        <property type="nucleotide sequence ID" value="XM_002766896.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ99659">
        <property type="protein sequence ID" value="EEQ99659"/>
        <property type="gene ID" value="Pmar_PMAR010923"/>
    </dbReference>
    <dbReference type="GeneID" id="9051499"/>
    <dbReference type="OrthoDB" id="759498at2759"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="PTHR17605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BOP1NT" evidence="5">
        <location>
            <begin position="94"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ99659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="723" mass="82097" checksum="2AC102229D73AEB1" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C5LVF0</accession>
    <name>C5LVF0_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cationic amino acid transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR017499</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG685853">
        <property type="protein sequence ID" value="EEQ99293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766576.1">
        <property type="nucleotide sequence ID" value="XM_002766530.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ99293">
        <property type="protein sequence ID" value="EEQ99293"/>
        <property type="gene ID" value="Pmar_PMAR017499"/>
    </dbReference>
    <dbReference type="GeneID" id="9045310"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ99293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="314" mass="34089" checksum="49F70F1E3FAA4305" modified="2009-07-28" version="1" fragment="single">QARRLVPRAIIVTIIICCIVYVLVAVAFVHLAPLASVNMNAPLATAFEARGATVLEFVVSLGAVGNTMTSVMSSMIVQPRIMLRMSSDGLLPRSIGRLTSSGTPSVALIITIVVSSALALVIDFEALADIVSFGALLSFLAVCLCTMLGRVVPPWIHHQQTSSEQPSETYGKPGMQEEPPRVADVQTSSPLRPHYPREILLMVLFFEVATLIFGVLFLHNLVSIFFCLPFLIISLIAGIATARIVRTYLNYTDVNSNENIDSFRVPGAPEVPLIGMFVNTQVHDIWPTISGSHSRLGSDARCDHILLVLLNTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5LVH8</accession>
    <name>C5LVH8_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosine kinase</fullName>
            <ecNumber evidence="4">2.7.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR013317</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4"/>
    <dbReference type="EMBL" id="GG685894">
        <property type="protein sequence ID" value="EEQ99265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766548.1">
        <property type="nucleotide sequence ID" value="XM_002766502.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ99265">
        <property type="protein sequence ID" value="EEQ99265"/>
        <property type="gene ID" value="Pmar_PMAR013317"/>
    </dbReference>
    <dbReference type="GeneID" id="9045118"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="PTHR45769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="79"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="245"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ99265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="418" mass="45578" checksum="DBA1739F54B11A38" modified="2009-07-28" version="1">MSGSVLDEESSSSSLFASCPLGGVESFSVVSYDHPILDLVATVDDAYGFGLKANTQRLTDGSDEDKKLFARMLGDGELTVHRIAGGQAMNSLRGVKWWFDRHEADPEYNDVSFANTSVRIVGSVGDDEYANVLREACVEAGLETDFEVFPGGRTGKCCALLKDKKRTMITDLGVAPDFRAGPERGIPTDCRILYTTAFYACGDGYACREYIPNHPQIKSGYTKLFAGLSAAWACKNDDFTYMARYACDVVFGNEVEFTAFAEHLGIVGVSKMSPREIAEAVSAFMKPGAWAIMTQGPDPVVCCSNLTDTCDAFTHTVRDLDPLAISDDIGAGDGFVGGFIAAIYARLLASDFTPRSMPSPVESIISNARDDDTSYLLPGDDSRSDTWYWITRQMVMDGVEEGIYCARQVMKHTGCQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>C5LVP6</accession>
    <name>C5LVP6_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR018286</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG685971">
        <property type="protein sequence ID" value="EEQ99169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766452.1">
        <property type="nucleotide sequence ID" value="XM_002766406.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ99169">
        <property type="protein sequence ID" value="EEQ99169"/>
        <property type="gene ID" value="Pmar_PMAR018286"/>
    </dbReference>
    <dbReference type="GeneID" id="9044843"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ99169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="376" mass="43362" checksum="5BC07B34C2076CD3" modified="2009-07-28" version="1">MSRYIGPYRPTWEPLFDLFGSFDPDPVVQKMINEAMERAHFHGKDWAYRRLNKSEKLGYIRNPPPLAWCIYQVPGPSSESIYQLYLNDCFLAESVVAEWGVARRDVDTEIRQDILKLPSPEETGHTGKFGHDINIRQKPKRGHLFFRGEPRNTKRNVVGQMVECNKYIIDFSRPIAMRSLIPPILPAVRSALQDIIDFSVEYASERGLDPDSALSFRILVKMAQQPWHVDDETVKEGVRVVMEWLGTRLLARYWDYITVDATRVRSHAQLPHFERQGLGGAVCVSPQQLEASQGSPFYYDSRHPRSVRVPLECPPFQLWERFPNTAFGCEEKTGAARQVWVTFGYRLTDHPSRTETSRLQEELSWAKPGLCFMAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>C5LVW5</accession>
    <name>C5LVW5_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR023838</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG686026">
        <property type="protein sequence ID" value="EEQ99116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766399.1">
        <property type="nucleotide sequence ID" value="XM_002766353.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ99116">
        <property type="protein sequence ID" value="EEQ99116"/>
        <property type="gene ID" value="Pmar_PMAR023838"/>
    </dbReference>
    <dbReference type="GeneID" id="9044626"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ99116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="208" mass="23801" checksum="759E1B1F6A1AE2B7" modified="2009-07-28" version="1">MYLPLPRRRRRCRRSCRVDEHHRMVMTILMPPTRAEEGHHESTTALDRLLGLQGDASPKLQRNISLESRELSDRISTAARNATENGKLFRTEKQRVNRSLGDYDDEEDSEARKINFGDEVNVRFFNRSGSSLSLRGRSHSQHEVADLASCVKSFDGRSNNKSCLGKTTSYENLGDLETIAEEMGKPREMLVSGRRGRSRSFADLEEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C5LWH8</accession>
    <name>C5LWH8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-1,3-n-acetylglucosaminyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Pmar_PMAR012904</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG686192">
        <property type="protein sequence ID" value="EEQ98891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766174.1">
        <property type="nucleotide sequence ID" value="XM_002766128.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98891">
        <property type="protein sequence ID" value="EEQ98891"/>
        <property type="gene ID" value="Pmar_PMAR012904"/>
    </dbReference>
    <dbReference type="GeneID" id="9063101"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002954780" evidence="8">
        <location>
            <begin position="33"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ98891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="907" mass="103908" checksum="FF9F3DF0C1805589" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C5LWJ8</accession>
    <name>C5LWJ8_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heme O synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Pmar_PMAR012924</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG686192">
        <property type="protein sequence ID" value="EEQ98911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766194.1">
        <property type="nucleotide sequence ID" value="XM_002766148.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98911">
        <property type="protein sequence ID" value="EEQ98911"/>
        <property type="gene ID" value="Pmar_PMAR012924"/>
    </dbReference>
    <dbReference type="GeneID" id="9063120"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ98911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="350" mass="37170" checksum="DDCA797BB9A7B9B0" modified="2009-07-28" version="1">MLLISSSSSSRRFPVSVTSKIINSAKVFAGVEMRNSICIITTRTSTSTGAPTDIKSPLVNLKVARLVSLDARNEVVVGGGRSKMKLRAVARDYWKLSKGGLSVYAALSALPGYLVSCGLLTGAIGSVVLNSTGVFMGTLLCAASSQAVNQIMEKERDGNMTRTKSRPLPTGRITTFEAGVFAALTCGVGNGILYSVGGAVPVIVALSTAALYTMVYTPMKTKSPYNTHIGSIAGSLPVLIGFSVAGVPLFADFAPWMLFMLQTLWQFPHFYALAWLYRSDYSAAGYKMFPLDDDTGRKTAAMCWPYMVGLAVLPVVASGLGVTSWMFAFSAMVVTAEGGDVVLEYLCCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>C5LWP2</accession>
    <name>C5LWP2_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR007217</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG686213">
        <property type="protein sequence ID" value="EEQ98838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766121.1">
        <property type="nucleotide sequence ID" value="XM_002766075.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98838">
        <property type="protein sequence ID" value="EEQ98838"/>
        <property type="gene ID" value="Pmar_PMAR007217"/>
    </dbReference>
    <dbReference type="GeneID" id="9062965"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002953193" evidence="1">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ98838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="158" mass="16821" checksum="388EA0B968DF98D0" modified="2009-07-28" version="1">MFSFTLLISSFIALGSVEIPEQFYNESMGKGQDISEGIISNDMDGLVGNTNLPYYGKPTGCTCSGEKFVGSCECPNNQDLFALTGGYSTCYAICAKPCAQASDCPPAPKSASVHIKCVLGRCLLDCSGYDGICAKEDGSVCFRYRMGPAKGTMCSWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>C5LWP3</accession>
    <name>C5LWP3_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR007217</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG686213">
        <property type="protein sequence ID" value="EEQ98837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766120.1">
        <property type="nucleotide sequence ID" value="XM_002766074.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98837">
        <property type="protein sequence ID" value="EEQ98837"/>
        <property type="gene ID" value="Pmar_PMAR007217"/>
    </dbReference>
    <dbReference type="GeneID" id="9062965"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002952574" evidence="1">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ98837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="131" mass="13956" checksum="2AECA89094DB33C8" modified="2009-07-28" version="1">MFSFTLLISSFIALGSVEIPEQFYNESMGKGQDISEGIISNDMDGLVGNTNLPYYGKPTGCTCSGEKFVGSCECPNNQDLFALTGGYSTCYAICAKPCAQASDCPPAPKSASVHIKYRMGPAKGTMCSWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>C5LWP4</accession>
    <name>C5LWP4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR007217</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG686213">
        <property type="protein sequence ID" value="EEQ98839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766122.1">
        <property type="nucleotide sequence ID" value="XM_002766076.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98839">
        <property type="protein sequence ID" value="EEQ98839"/>
        <property type="gene ID" value="Pmar_PMAR007217"/>
    </dbReference>
    <dbReference type="GeneID" id="9062965"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ98839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="132" mass="14163" checksum="829DD562FDB0733C" modified="2009-07-28" version="1">MVNLRSCSYYYILMSDMDGLVGNTNLPYYGKPTGCTCSGEKFVGSCECPNNQDLFALTGGYSTCYAICAKPCAQASDCPPAPKSASVHIKCVLGRCLLDCSGYDGICAKEDGSVCFRYRMGPAKGTMCSWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>C5LXK6</accession>
    <name>C5LXK6_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium-dependent protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">Pmar_PMAR008410</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG686575">
        <property type="protein sequence ID" value="EEQ98528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002765811.1">
        <property type="nucleotide sequence ID" value="XM_002765765.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98528">
        <property type="protein sequence ID" value="EEQ98528"/>
        <property type="gene ID" value="Pmar_PMAR008410"/>
    </dbReference>
    <dbReference type="GeneID" id="9041047"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="139"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="551"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ98528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="611" mass="67994" checksum="5500CC0EAF79ADF7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>C5LY49</accession>
    <name>C5LY49_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR013727</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG686772">
        <property type="protein sequence ID" value="EEQ98379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002765662.1">
        <property type="nucleotide sequence ID" value="XM_002765616.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98379">
        <property type="protein sequence ID" value="EEQ98379"/>
        <property type="gene ID" value="Pmar_PMAR013727"/>
    </dbReference>
    <dbReference type="GeneID" id="9040846"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ98379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="366" mass="39972" checksum="4A463AF9CDA22885" modified="2009-07-28" version="1">MSIGSTMERRPPRSTSANLSRLMYSNKSLSIEAFNAEVRTHETSLKEKRKSLEPTASRRITMDPRKRASYSTASHTYSAATVESVNSQDMVNLEERYKQQIRSAVANRDKQIQALEGRLRAAEAAMAEKDALLLALNQDLLDKRLLTSTGRELEVAKRHLQSISQRFNLRFGVDPFSGLSGYYAVTDTPNGWPSSTEDKCGVEGGRTSGVHSSLNDSAPSVLIPDEFDSILSDGIISAEENAHIRTVIKTKHSRKNREQSPHGLLIGRFSHRNWSKSQPATPASHCSMKPADPVDEAVRALVESLRGGGVAVPSVERTSDGRAAGGHHYLIGGSIRVECSLLHGTVVAKLPKGRIVPLREIIGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5LYN9</accession>
    <name>C5LYN9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tolA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR002097</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG686808">
        <property type="protein sequence ID" value="EEQ98277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002765560.1">
        <property type="nucleotide sequence ID" value="XM_002765514.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98277">
        <property type="protein sequence ID" value="EEQ98277"/>
        <property type="gene ID" value="Pmar_PMAR002097"/>
    </dbReference>
    <dbReference type="GeneID" id="9040718"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ98277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="571" mass="64189" checksum="712E802F5B3E8362" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5LYU0</accession>
    <name>C5LYU0_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR002392</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG686832">
        <property type="protein sequence ID" value="EEQ98113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002765396.1">
        <property type="nucleotide sequence ID" value="XM_002765350.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98113">
        <property type="protein sequence ID" value="EEQ98113"/>
        <property type="gene ID" value="Pmar_PMAR002392"/>
    </dbReference>
    <dbReference type="GeneID" id="9040547"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ98113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="247" mass="27612" checksum="5EF5AEFF35F6A91B" modified="2009-07-28" version="1">MSVDHVRLAQLRKNLSSKSAIISALGELSEMANDSETIKDPAFVEVCHRAFTVLNTRFSAAVYWQAGLELFLNMQFTCGEADVTLPECDKWAARALEESDEESKAKAKDRVRAAVRSGGGHQQQQQLLDLLGINLDDLQAVMADVGGDQGAPPASRDARNELRMVTLKEDELCVMCQEEMKQGSKAKKMPECGHVFHDHCIMEWLERHNTCPLCRNDDLQTEKKAFDDIAEKVRLSRKAERTSGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5LZ61</accession>
    <name>C5LZ61_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR016147</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG686838">
        <property type="protein sequence ID" value="EEQ98070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002765353.1">
        <property type="nucleotide sequence ID" value="XM_002765307.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98070">
        <property type="protein sequence ID" value="EEQ98070"/>
        <property type="gene ID" value="Pmar_PMAR016147"/>
    </dbReference>
    <dbReference type="GeneID" id="9040495"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ98070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="215" mass="23027" checksum="BB4403EEC1210D02" modified="2009-07-28" version="1">MVPQRPRPPPTRITEDDVDISALSCLDDLLAQLDSAVHRREVYLVRSDMKPVPREEANLDKRIASPSETTTTVASEGSVKKKKAEQPTSRKKKGGAREDVHKVSSGSLKQRHPSSSSSSPSSSSPASGLRKLAEKRHLHKGSSSSSRKRKGSRRNSADDLSDFIVPPGAPLSSESSSDDDTPDSPSSSSSSSSSSVLSDSDVVLNGYEDDSGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>C5LZ85</accession>
    <name>C5LZ85_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR025500</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG686856">
        <property type="protein sequence ID" value="EEQ97878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002765161.1">
        <property type="nucleotide sequence ID" value="XM_002765115.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ97878">
        <property type="protein sequence ID" value="EEQ97878"/>
        <property type="gene ID" value="Pmar_PMAR025500"/>
    </dbReference>
    <dbReference type="GeneID" id="9037616"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ97878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="284" mass="30530" checksum="F0A7F20EDEED078D" modified="2009-07-28" version="1">MVVLDMASGKGGPPGAMDDQITLLDGQRAAASLLEVNSGPVSEGAMEEATVTDTVGDWGQSSTYSRCVQPIASAAALVVESDYIRSLVRFLAVCVVAASYSRFLAAYCGVPQKINRSWQHWMFTLVVAFCGATAIHRICRPSRLWVTAATPFVYSLIQMVVGAIPLTADTDYMKSAPALGLATIVVAASSLGILMTRYAYYHVDCVGRLMMGIVFLIFLWLRTPPGYSFHLHHYLHCTLLALAFGRVKGDEAVPAIAQAILIGMALQGAAVWGTDSLYDEKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C5M0P2</accession>
    <name>C5M0P2_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DYNc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR029123</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG687161">
        <property type="protein sequence ID" value="EEQ97400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002764683.1">
        <property type="nucleotide sequence ID" value="XM_002764637.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ97400">
        <property type="protein sequence ID" value="EEQ97400"/>
        <property type="gene ID" value="Pmar_PMAR029123"/>
    </dbReference>
    <dbReference type="GeneID" id="9054879"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="PTHR11566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DYNc" evidence="1">
        <location>
            <begin position="32"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ97400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="662" mass="76254" checksum="29C641E66FCA0BF2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C5K4U2</accession>
    <name>C5K4U2_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR010098</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG670562">
        <property type="protein sequence ID" value="EER20364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002788568.1">
        <property type="nucleotide sequence ID" value="XM_002788522.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER20364">
        <property type="protein sequence ID" value="EER20364"/>
        <property type="gene ID" value="Pmar_PMAR010098"/>
    </dbReference>
    <dbReference type="GeneID" id="9053916"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="261"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER20364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="574" mass="65281" checksum="A0CC8BD8DF845493" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5K550</accession>
    <name>C5K550_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR010215</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG670562">
        <property type="protein sequence ID" value="EER20472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002788676.1">
        <property type="nucleotide sequence ID" value="XM_002788630.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER20472">
        <property type="protein sequence ID" value="EER20472"/>
        <property type="gene ID" value="Pmar_PMAR010215"/>
    </dbReference>
    <dbReference type="GeneID" id="9054023"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER20472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="442" mass="50427" checksum="F2E31163406FBC4F" modified="2009-07-28" version="1">MPHHRLPAGVCRHREPSLEAIPTVGSKALRTPPRAESCTYDVLPLNVVYERNRTGFEETKEFQVVTNMVIAARYRVVGFLGSAAFSKAVQAWDMRFNQHVCMKIIKNDKDFFDQSLDEIKLLSLLQLNAPDGDIDKTRCLRMIDYFYHKEHLIIVTELLRDNLYEFSKLTRVSSPPQPLSPVPAFGSPVATPPTTPLLAPVSQYFTIGRLQKITHQVLTALEYIHSMGLMHCDLKPENILLQSYTTASVKVIDFGSSCFITDHLATYIQSRCYRAPEVILGLSYDTSIDIWSLGCIVAELWTSTVLFQNDSIQSLLARVIGIIGPFPEHMMRLGKLIPRYFTRDRQIYMEHPPVHGMRDMSTSRSASWDNRQRASPPSTPRLLQILVPKETSLHQRMRTNDEAFLDFITQCLQLDPNLRPTAREALQHPWLTKSRYPDGLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C5K557</accession>
    <name>C5K557_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Pmar_PMAR010220</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="GG670562">
        <property type="protein sequence ID" value="EER20478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002788682.1">
        <property type="nucleotide sequence ID" value="XM_002788636.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER20478">
        <property type="protein sequence ID" value="EER20478"/>
        <property type="gene ID" value="Pmar_PMAR010220"/>
    </dbReference>
    <dbReference type="GeneID" id="9054028"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EER20478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="311" mass="35564" checksum="13F44F0D3251551F" modified="2009-07-28" version="1">MTYLDEMKQVHIDGKTSYTVPRHMEFIRKVGSGAYGTVASFSDGRDHKVAVKKVQNAFDDLIDAKRILREIKLLRTFDHDNIVRILDMYPPQSPDFEDIYIVTDLMETDLHRVIYSKQSLTDEHYQYFIYQMLRGLKYLHSANVIHRDLKPSNILVNKNCDLKICDFGLARGFSHGCDDSNPDPNLTDYVVTRWYRAPEVVLLASEYTKAIDVWAVGCILCELLGRRALFTGKDHLDQIKKIIEVSGMPTEEELHWLPPDGPARRFIRKCPQSRGKDMHELYPEANALAIDAHLCGAILEAPLLGGISQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>C5K602</accession>
    <name>C5K602_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR007293</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG670840">
        <property type="protein sequence ID" value="EER20032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002788236.1">
        <property type="nucleotide sequence ID" value="XM_002788190.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER20032">
        <property type="protein sequence ID" value="EER20032"/>
        <property type="gene ID" value="Pmar_PMAR007293"/>
    </dbReference>
    <dbReference type="GeneID" id="9059019"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002953747" evidence="1">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER20032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="182" mass="20199" checksum="FF650F3B3548EFF5" modified="2009-07-28" version="1">MLMICSIIITVIMEASSHSWVINLVGDIKAGLPRMGLTTHQHPDQYYACMGLPPPYKPLDESSLRPCRRAGTTGATNMHQRAEVTRGSKLHVSWMGNGHTNSVSDGTCIVFKIAPYAEDPSWENFTVLEKCLPFYHTNVAKDPTSADITIPADTEPGIYTVLYMWSKFDGVYYATCSDIIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C5K831</accession>
    <name>C5K831_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR012704</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG671079">
        <property type="protein sequence ID" value="EER19716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002787920.1">
        <property type="nucleotide sequence ID" value="XM_002787874.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER19716">
        <property type="protein sequence ID" value="EER19716"/>
        <property type="gene ID" value="Pmar_PMAR012704"/>
    </dbReference>
    <dbReference type="GeneID" id="9057880"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="PTHR11134"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Adaptin_N" evidence="6">
        <location>
            <begin position="24"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER19716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="615" mass="66880" checksum="D7102109AA0ADC5F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C5KBF0</accession>
    <name>C5KBF0_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR005419</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG671811">
        <property type="protein sequence ID" value="EER18476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002786680.1">
        <property type="nucleotide sequence ID" value="XM_002786634.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER18476">
        <property type="protein sequence ID" value="EER18476"/>
        <property type="gene ID" value="Pmar_PMAR005419"/>
    </dbReference>
    <dbReference type="GeneID" id="9049357"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="PTHR31975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER18476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="724" mass="79717" checksum="5B7D62733AA31170" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>C5KBX1</accession>
    <name>C5KBX1_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Pmar_PMAR019883</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG671946">
        <property type="protein sequence ID" value="EER18002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002786206.1">
        <property type="nucleotide sequence ID" value="XM_002786160.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER18002">
        <property type="protein sequence ID" value="EER18002"/>
        <property type="gene ID" value="Pmar_PMAR019883"/>
    </dbReference>
    <dbReference type="GeneID" id="9063345"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EER18002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="555" mass="60522" checksum="8EF0A30A2CCF4F28" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>C5KD91</accession>
    <name>C5KD91_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitoferrin-1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Pmar_PMAR008086</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG672055">
        <property type="protein sequence ID" value="EER17524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002785728.1">
        <property type="nucleotide sequence ID" value="XM_002785682.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER17524">
        <property type="protein sequence ID" value="EER17524"/>
        <property type="gene ID" value="Pmar_PMAR008086"/>
    </dbReference>
    <dbReference type="GeneID" id="9062862"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="16"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="130"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="227"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EER17524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="330" mass="35945" checksum="F39375D8E4607182" modified="2009-07-28" version="1">MAVQMGDDSTLPTTKLTSASSFIAGATAGLVCDATVFPMDTIRVRQQARHWPASSAIATESFARPDRPAVSMPQRYSLISEAVAILKHEGARGFYKGLSVVMLTSCPAFGIYYSAYEFSKSKLRPATGWSSDAIHLASGAIANVFGMVIWTPQEVIKSQTQVQVKTAVSPRHIVIDIYREYGIRGFYRGVVIGSLTWTPLSAIWFMTYERLKPLNFGRDELARDGSVSAAWLALSGFIAGVVACTTTSPIDVVKTQYQVAGRGIASSSSSQFTSSRSSSIRDIAIALLRNEGVRGFFRGVCAKSLWYGTFMAINITVYDRVRLSLQGFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C5KDL6</accession>
    <name>C5KDL6_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Pmar_PMAR022254</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG672124">
        <property type="protein sequence ID" value="EER17319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002785523.1">
        <property type="nucleotide sequence ID" value="XM_002785477.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER17319">
        <property type="protein sequence ID" value="EER17319"/>
        <property type="gene ID" value="Pmar_PMAR022254"/>
    </dbReference>
    <dbReference type="GeneID" id="9062373"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="34"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EER17319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="459" mass="50507" checksum="0004184DF8939F47" modified="2009-07-28" version="1">MDNSGPLSTEEYYSLKRLARLRYRLKYEPRRIIDLSLIFISIFIEWLGNTLLAPITPWYIDKLASGMDEGAAASILMASYAVGTFLSSLFTGPLSDRYGRRPVFILAMFLYTISYFLVANAWNIASFAGFRAIGGVSAGTRPVLYAFITDSSRVEDMRFYGSCISICNTVGGALGPTIGGWLASVGISFPFYFMGVLAAILFLLQLFFLRETKPREDKPEWLKWEYYECWKHQHQQQQGRDQANDVSSSDNLPPPLPPSGSIDAPPKGMSPMDEAKDMGLGAWSKKNKWFITTLVCLCLAAFAGQYAGNSWATVFGVLGADRYDLTEQQNGEAMGIQALVVIICTILYMYISNKIKPGLVAAFGFCLVVLAVIVPFIYSIWGTIIIGMCVYVGITFFFAGMAYCSALISPPKSRGLINSITMGVTNVGKPISDGGPCCLLIPPPIHRWCAGPSSRRSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C5KFG1</accession>
    <name>C5KFG1_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cg4 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR012304</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG672742">
        <property type="protein sequence ID" value="EER16782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002784986.1">
        <property type="nucleotide sequence ID" value="XM_002784940.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER16782">
        <property type="protein sequence ID" value="EER16782"/>
        <property type="gene ID" value="Pmar_PMAR012304"/>
    </dbReference>
    <dbReference type="GeneID" id="9063896"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER16782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="483" mass="54763" checksum="27AAC5DC9D289A35" modified="2009-07-28" version="1">MLSPLFKVRDFAVTDFTQQGIEVAWQQQQQATSTTDNDDVEGCSSIIKRTEVFPPRSTLNTVKMLTFYRKEAFELWAQYTNSEDHGDDASLGRYTIQVPHNSENDEGPKKIKVRAKLSLHGTFSIENAIMIEEEEYQVVEKERRRRRPINKETNDDENMVDASPSAAAATTTITNDDVNMQPAEAPAAPAASGISSEKEGKGDEFEEDEEEELVEVTKIKTRTKKTDIPIIRSGLPGMSEDRLRAAEDDELKMRNIDREVAETDEKRNELESYIFESSAAQREELSNILMQTEDWVYDHYEATKAEYMDKLIEIRALGDGAESRAMEASLRPEAEARAQDVIQKYRSLAQSPDIAYAHIAIERKEYILEECHKLESWLSQQKALQVRQPLYLQPVYTVSQLNDKTDALIKLADGILSEKPPSSPPSSKKAQDESAESNSKEEERGSPEPIVEEPDDSSDDQDGEEEEEEVAKDDDHHHHMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C5KKQ7</accession>
    <name>C5KKQ7_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR006335</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG673701">
        <property type="protein sequence ID" value="EER14938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002783142.1">
        <property type="nucleotide sequence ID" value="XM_002783096.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER14938">
        <property type="protein sequence ID" value="EER14938"/>
        <property type="gene ID" value="Pmar_PMAR006335"/>
    </dbReference>
    <dbReference type="GeneID" id="9061824"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PTHR11315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER14938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="136" mass="15800" checksum="993B9982ADBD1358" modified="2009-07-28" version="1">MTYNHHDWGVWVDQLSSFPEAEKNFKVLATSTSTEVDREFIAVVEGRNEFDGVWAVQFHPEKPSYEWNSKLSVDHSRTSVEANRFFADFFISRVREHQPYRRCLPVSEEASVLVYNYPLHFTGWIGSPQTIAAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C5KN72</accession>
    <name>C5KN72_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR020888</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG674563">
        <property type="protein sequence ID" value="EER14106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002782311.1">
        <property type="nucleotide sequence ID" value="XM_002782265.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER14106">
        <property type="protein sequence ID" value="EER14106"/>
        <property type="gene ID" value="Pmar_PMAR020888"/>
    </dbReference>
    <dbReference type="GeneID" id="9059977"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER14106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="613" mass="71357" checksum="A945697A856B53CF" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C5KNF9</accession>
    <name>C5KNF9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR022507</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG674604">
        <property type="protein sequence ID" value="EER13975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002782180.1">
        <property type="nucleotide sequence ID" value="XM_002782134.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER13975">
        <property type="protein sequence ID" value="EER13975"/>
        <property type="gene ID" value="Pmar_PMAR022507"/>
    </dbReference>
    <dbReference type="GeneID" id="9059690"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="393"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER13975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="649" mass="74133" checksum="9440079B2516DF36" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C5KPZ7</accession>
    <name>C5KPZ7_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Pmar_PMAR000131</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="GG675180">
        <property type="protein sequence ID" value="EER13544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002781749.1">
        <property type="nucleotide sequence ID" value="XM_002781703.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER13544">
        <property type="protein sequence ID" value="EER13544"/>
        <property type="gene ID" value="Pmar_PMAR000131"/>
    </dbReference>
    <dbReference type="GeneID" id="9042284"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006499">
        <property type="term" value="P:N-terminal protein myristoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="PTHR11377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="8">
        <location>
            <begin position="59"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EER13544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="395" mass="45479" checksum="A55989A28EF37038" modified="2009-07-28" version="1">MSIAAAPPTTTHKFWNTQPVPQLDADPVPQDARGPIDEAKKVSDIPKEPYNLPAAFEWSNIDVNDPEQIQEVYTLLNENYVEDDEAMFRFDYSPEFLRWALTPPHYVPEWHFGVRVKSNGKLVGFITGIPATMDVRGDELRTVEINFLCVHKKLRSKRLAPVLIKEVTRRVNLTDRWQAVYTSGAILPRPVTTARYHHRSLNPKKLCEVGFTRLAPRMTMARCIKLYKVADQPSTSGLRPMEMKDRKQVTKLLNEYLSKFKVHPVLSQHEVGHWLLPRENVIYTYVREENGKVTDFLSFYSLPSSVLGNDKHKTLYAAYSYYNVANTVSLKQLMSDALVLAKHAGYDVFNALNLMDNKEFLEDLKFGRGDGDLQYYLYNWKCPFMEPQDMGLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C5KR75</accession>
    <name>C5KR75_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR019505</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG675767">
        <property type="protein sequence ID" value="EER12977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002781182.1">
        <property type="nucleotide sequence ID" value="XM_002781136.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12977">
        <property type="protein sequence ID" value="EER12977"/>
        <property type="gene ID" value="Pmar_PMAR019505"/>
    </dbReference>
    <dbReference type="GeneID" id="9056304"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER12977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="688" mass="75631" checksum="283366507E20CD7C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C5KRG9</accession>
    <name>C5KRG9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR000677</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG675796">
        <property type="protein sequence ID" value="EER12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002781147.1">
        <property type="nucleotide sequence ID" value="XM_002781101.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12942">
        <property type="protein sequence ID" value="EER12942"/>
        <property type="gene ID" value="Pmar_PMAR000677"/>
    </dbReference>
    <dbReference type="GeneID" id="9056054"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="218" mass="23714" checksum="C49F9E21E332B139" modified="2009-07-28" version="1">MFKEVAEAYGVLSDPQKKRIYDTYGRSGLERGNSSSGASHTAGGYHHYDMNDAFSVFEQFFGSHDPWQQFDDLVNGNLLRAMSSSSSRGGGAWMGMSAFDDPFFTQGFTGQSSSRRTNFANFSSSVSSGGFARSSTGSAGGDMSSGMSQSTSTSTRTVNGHTVTITEKQIRHPDGRIQRSVTEKRYDPRTGKTQERRSIEDTGGMSKRSTADKHLAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C5KTJ9</accession>
    <name>C5KTJ9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR016578</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="EMBL" id="GG676169">
        <property type="protein sequence ID" value="EER12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002780383.1">
        <property type="nucleotide sequence ID" value="XM_002780337.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER12178">
        <property type="protein sequence ID" value="EER12178"/>
        <property type="gene ID" value="Pmar_PMAR016578"/>
    </dbReference>
    <dbReference type="GeneID" id="9061255"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="PTHR23292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="6">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="296" mass="33489" checksum="7F5B0988F649174A" modified="2009-07-28" version="1">MTGAFSRKDGSYIYRKVPVDAEEGSVEMNVVNNTRVSTRAEPERERLPTFDMVPVECRCPFCRADITTFITHEASIVSYLLALVLVLILQWLSICILPVVWPLLKDTVHRCPNCLNKIGSRSKIALPTSLKNDVLTFRIGHCAVVLARRYVVILLALVTVIGLFYVARSSGVMQPAMVPRGPDIDASWKDFLTDCGERAYLGNPLHSVKAFEEKYKYQTVKWKGRVVRIREGIDLWLFKTKSFAMIKMFPPQQAYRPDVVDLILLFDGPQQHDEVSLIPAGSWAQFEASLLSLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C5KUV5</accession>
    <name>C5KUV5_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA_28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Pmar_PMAR002273</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG676384">
        <property type="protein sequence ID" value="EER11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779875.1">
        <property type="nucleotide sequence ID" value="XM_002779829.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER11670">
        <property type="protein sequence ID" value="EER11670"/>
        <property type="gene ID" value="Pmar_PMAR002273"/>
    </dbReference>
    <dbReference type="GeneID" id="9047096"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="3">
        <location>
            <begin position="13"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EER11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="522" mass="58767" checksum="D234A3D4A3308DDB" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C5KUW8</accession>
    <name>C5KUW8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING finger protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR002285</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG676384">
        <property type="protein sequence ID" value="EER11682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779887.1">
        <property type="nucleotide sequence ID" value="XM_002779841.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER11682">
        <property type="protein sequence ID" value="EER11682"/>
        <property type="gene ID" value="Pmar_PMAR002285"/>
    </dbReference>
    <dbReference type="GeneID" id="9047107"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER11682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="247" mass="27584" checksum="1D1AF63D4047BDF1" modified="2009-07-28" version="1">MSVDHVRLAQLRKNLSSKSAIIAALGELSEMANDSETIKDAAFVEVCHRAFTVLNTRFSAAVYWQAGLELFLNMQFTCGRADVTLPDCDEWAARALEESDEESKAKAKDRVRAAVRSGGGHQQQQQLLDLLGINLDNLQAVMADVGGDQGAPPASRDARNELRMVTLEEDELCVMCQEEMKQGSKAKKMPECGHVFHDHCIMEWLERHNTCPLCRNDDLQTEKKAFDDIAEKVRLSRKAERTSGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>C5KV76</accession>
    <name>C5KV76_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium-dependent protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR009835</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG676416">
        <property type="protein sequence ID" value="EER11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779827.1">
        <property type="nucleotide sequence ID" value="XM_002779781.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER11622">
        <property type="protein sequence ID" value="EER11622"/>
        <property type="gene ID" value="Pmar_PMAR009835"/>
    </dbReference>
    <dbReference type="GeneID" id="9047036"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="393" mass="44763" checksum="0440054785599B22" modified="2009-07-28" version="1">MKMLDHPNIIKLFETFEDHRNIYLIMELCTGGELFDRIIDEGRFTEVQAAIVMQQIFRAVYYMHENHIVHRDLKPENFLFLNKDPIEKSWIKLIDFGLSTHFNDNELMKTKAGTPYYVAPQVLAGQYDQECDLWSCGVIMYILLCGYPPFYGETDADVLTKVRLGNYTFNASDWKNISADAKDLIRKLLKMNPQERYTAEQALNHPWVKNHAPGAEDAPLEGVQMNNLKSFRSLNKLKKAALNIIAQQMPDEEIVQLKKVFTSMDTNGDGQLTIQEVVEGIQKSGLKDIPDDLMDIMTQVDSDGSGVIDYTEFLAATLDKKKYIQEDRLWGAFRVFDRDGDGKITPLELAEVLNNGEVSDLVSGHIEEILKQADANGDGEIDFDEFVAMMAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>C5KVW5</accession>
    <name>C5KVW5_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR020708</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG676749">
        <property type="protein sequence ID" value="EER11356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779561.1">
        <property type="nucleotide sequence ID" value="XM_002779515.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER11356">
        <property type="protein sequence ID" value="EER11356"/>
        <property type="gene ID" value="Pmar_PMAR020708"/>
    </dbReference>
    <dbReference type="GeneID" id="9046714"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER11356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="603" mass="67691" checksum="D43A81D4276273F5" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C5KVX2</accession>
    <name>C5KVX2_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR020715</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG676749">
        <property type="protein sequence ID" value="EER11364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779569.1">
        <property type="nucleotide sequence ID" value="XM_002779523.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER11364">
        <property type="protein sequence ID" value="EER11364"/>
        <property type="gene ID" value="Pmar_PMAR020715"/>
    </dbReference>
    <dbReference type="GeneID" id="9046698"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER11364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="703" mass="76347" checksum="780899BC44E0F7EE" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>C5KX23</accession>
    <name>C5KX23_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR029651</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG677097">
        <property type="protein sequence ID" value="EER11026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779231.1">
        <property type="nucleotide sequence ID" value="XM_002779185.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER11026">
        <property type="protein sequence ID" value="EER11026"/>
        <property type="gene ID" value="Pmar_PMAR029651"/>
    </dbReference>
    <dbReference type="GeneID" id="9056241"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002954401" evidence="2">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER11026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="193" mass="19834" checksum="0218B1FAFB4DC8EA" modified="2009-07-28" version="1">MIRPLLLLATILCVSEAMSPNKGVPDAVQPHVDESPDQYCQSLCGPSNLCRDKGSYCKAYGPPGDGVGVCQGFYYRPDNSLCYFGFSDDCPENRPVFCRGNGTTTPGPTTTTSPVSTTTAGPSTTTAPGNTTTAGPSTTTAPGNTTTPGPSTTTPAPSAAHPTGLYVGSGNFSGTAFSVNATFSENDTILEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C5KXS1</accession>
    <name>C5KXS1_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromodomain helicase-DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR000838</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG677256">
        <property type="protein sequence ID" value="EER10795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002779000.1">
        <property type="nucleotide sequence ID" value="XM_002778954.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10795">
        <property type="protein sequence ID" value="EER10795"/>
        <property type="gene ID" value="Pmar_PMAR000838"/>
    </dbReference>
    <dbReference type="GeneID" id="9039179"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="275"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="601"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="935"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="963"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER10795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116563" checksum="FC48DEF549DF949C" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C5KYU8</accession>
    <name>C5KYU8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiolproteinase SmTP1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Pmar_PMAR014310</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG677539">
        <property type="protein sequence ID" value="EER10346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002778551.1">
        <property type="nucleotide sequence ID" value="XM_002778505.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10346">
        <property type="protein sequence ID" value="EER10346"/>
        <property type="gene ID" value="Pmar_PMAR014310"/>
    </dbReference>
    <dbReference type="GeneID" id="9038103"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062171" evidence="2">
        <location>
            <begin position="16"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor_I29" evidence="4">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="118"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EER10346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="296" mass="32617" checksum="5D7C89684380B665" modified="2009-07-28" version="1">MLTPILLSSILGVFSEQTPLEVQNLFEAYKDEYDHDFGEEDANRLAIFHDNLKFIDEVNSRNLSYKLGITPFTHLTNDEFREFVTRGYSLGDWQQTMLRGIDSEAQTFGFEGSVDDDLPMRVDYVEKGWVTDVKFQGTVCGSCWAFGVAGALEGLHKNVTGQLVSLSEQELIDCSRAYGNNGCNGTRHLNDSYEYVADHGLETERAYKYVGKDGQCRRDVCEYAIKAGTISHVNVKSNSSSSMLAAVAFGGPVSAVSCAWAGVFQNYKSGIIKGGECGNLPSHVVLVVGYDRGHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C5KZ75</accession>
    <name>C5KZ75_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">Pmar_PMAR018226</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG677709">
        <property type="protein sequence ID" value="EER10224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002778429.1">
        <property type="nucleotide sequence ID" value="XM_002778383.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER10224">
        <property type="protein sequence ID" value="EER10224"/>
        <property type="gene ID" value="Pmar_PMAR018226"/>
    </dbReference>
    <dbReference type="GeneID" id="9038787"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="zf-RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="SSF90209"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="628"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="675"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="706"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EER10224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="814" mass="90959" checksum="CC3202CECB46531A" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>C5L0Q0</accession>
    <name>C5L0Q0_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">Pmar_PMAR022140</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678123">
        <property type="protein sequence ID" value="EER09702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777907.1">
        <property type="nucleotide sequence ID" value="XM_002777861.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER09702">
        <property type="protein sequence ID" value="EER09702"/>
        <property type="gene ID" value="Pmar_PMAR022140"/>
    </dbReference>
    <dbReference type="GeneID" id="9087302"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EER09702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="307" mass="34351" checksum="3A4C99908D4C8413" modified="2009-07-28" version="1">MGCYTISSGTDEELKKVPEIFPDLEAFLSNKDAMAEAFTTALVFINNNFDDNWTLATTIWQDIPHFRTAHHIGIDSAEDITTDAITKASHHHHDCMDSIKMYIVHMKGYGTMRKREAVIISIMKEISASKVAVLEYSIPPITGNDDDVLSNYTPDKSSVHITTTFNVALFENDAGANTKVTIAGLVPVGGKTEKLKLSIMAEREVKAQQKLMTLMYNYFTDTSEGRSLVINTRTTILGKVWKPLLSDSSIALSKLQLQFLKANSDTFNMLCNEEDHINTNSSDKTIPGGYRRVYTMYVIDKDYVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5L2L4</accession>
    <name>C5L2L4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Splicing factor, arginine/serine-rich, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR013453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678623">
        <property type="protein sequence ID" value="EER09029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777213.1">
        <property type="nucleotide sequence ID" value="XM_002777167.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER09029">
        <property type="protein sequence ID" value="EER09029"/>
        <property type="gene ID" value="Pmar_PMAR013453"/>
    </dbReference>
    <dbReference type="GeneID" id="9065016"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER09029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="141" mass="15967" checksum="262DDC8395CB7F4A" modified="2009-07-28" version="1" fragment="single">DSDSSSESSSSSSESPSRSPSRSRRDSSRGKGNMSSSQQKRRRPESPVKESRSSKSSADLNAWRKARDDAQAGPRQRYIERPSGRDGRSYERSRGESSRSPPSPRRRQRKDVVESPRRRKRKDAVEDSGRSRSRSISNRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C5L2T9</accession>
    <name>C5L2T9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR009996</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678662">
        <property type="protein sequence ID" value="EER09004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777188.1">
        <property type="nucleotide sequence ID" value="XM_002777142.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER09004">
        <property type="protein sequence ID" value="EER09004"/>
        <property type="gene ID" value="Pmar_PMAR009996"/>
    </dbReference>
    <dbReference type="GeneID" id="9064990"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER09004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="651" mass="72862" checksum="002408B677667999" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C5L369</accession>
    <name>C5L369_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR001511</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678697">
        <property type="protein sequence ID" value="EER08826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777010.1">
        <property type="nucleotide sequence ID" value="XM_002776964.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER08826">
        <property type="protein sequence ID" value="EER08826"/>
        <property type="gene ID" value="Pmar_PMAR001511"/>
    </dbReference>
    <dbReference type="GeneID" id="9043410"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER08826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="136" mass="15268" checksum="912F726E481DE6B5" modified="2009-07-28" version="1" fragment="single">PSCRSECRRHLLISDPSRGYSMKSFSSRGGGPLREFTTCQVQRHNKLNDCWICAHGRIYDVSEFMFQHAAGIRPLMQRAGGVQDASVDYDFHSSRSRHNEWRRLCIGRVVPCPLRGDPYGVTRTSSSSEGSGCGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C5L372</accession>
    <name>C5L372_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR007962</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678701">
        <property type="protein sequence ID" value="EER08822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002777006.1">
        <property type="nucleotide sequence ID" value="XM_002776960.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER08822">
        <property type="protein sequence ID" value="EER08822"/>
        <property type="gene ID" value="Pmar_PMAR007962"/>
    </dbReference>
    <dbReference type="GeneID" id="9043403"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER08822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="151" mass="16326" checksum="A2C7CDC6E3253B7D" modified="2009-07-28" version="1" fragment="single">ATAWSSVSCYGGQAAVPPPPPPPPPPPPPPSSTPFERRRVPAGWVAASRGSTAQGAGSRSALTGNLTYNPSGSMTVVEKEKRMELEKKRVLLQCTESIRKLLSKMNEAGITERQKEKYKVMIKRIKETMGSLDKGHHTIVHNKVASSGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C5L3Q4</accession>
    <name>C5L3Q4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p53 binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">Pmar_PMAR017688</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG678922">
        <property type="protein sequence ID" value="EER08632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002776816.1">
        <property type="nucleotide sequence ID" value="XM_002776770.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER08632">
        <property type="protein sequence ID" value="EER08632"/>
        <property type="gene ID" value="Pmar_PMAR017688"/>
    </dbReference>
    <dbReference type="GeneID" id="9042471"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="zf-RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="SSF90209"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EER08632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="432" mass="47304" checksum="8D350611FDE5532A" modified="2009-07-28" version="1">MGLLEGSDSIRDSTTTTTGQTTPLAMDRTIATGESGQGVITGEGLGQPQDNRSKSEGRSLAIREAEQNYGSDARGNGEGRQSQGEMMSVQQQQQQQPQPVQRQLTQEEQQGIIIAHHQQQLLMMQQQFRGAESYGVALDGQQMNAVFATGQGIGYQLPSAFLVGGNEHHHQQQRYHHNMGGFGTLNPSTTIQSEKARQTEGSWQCELCGNINYASRRFCNMNKCHAPRPLGEWRCVCGNINYRNRSVCNMRKCGLPRPMDLQSPALLYNQRAVESAQLQQQQQAGFSEHNAVPTVPLPQTVEEGVLLAHQQQMTGMWVCSACNNVNYPHRTVCNGHRCKRPRQEVDPVYAQQLGAVYGSSGNNQSPMLIPSAAGPFSPPLTGSMDARHGVVAGDAIPEGSWTCLECGNLNYPRRPFCNKRGCGAARPEGHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C5L7F8</accession>
    <name>C5L7F8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR020584</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG679899">
        <property type="protein sequence ID" value="EER07420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002775604.1">
        <property type="nucleotide sequence ID" value="XM_002775558.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER07420">
        <property type="protein sequence ID" value="EER07420"/>
        <property type="gene ID" value="Pmar_PMAR020584"/>
    </dbReference>
    <dbReference type="GeneID" id="9041166"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER07420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="897" mass="99916" checksum="B3AAD08051E69D6F" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>C5L7F9</accession>
    <name>C5L7F9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR020584</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG679899">
        <property type="protein sequence ID" value="EER07421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002775605.1">
        <property type="nucleotide sequence ID" value="XM_002775559.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER07421">
        <property type="protein sequence ID" value="EER07421"/>
        <property type="gene ID" value="Pmar_PMAR020584"/>
    </dbReference>
    <dbReference type="GeneID" id="9041166"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER07421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="900" mass="100277" checksum="F3780DF3AAD08051" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C5L7G6</accession>
    <name>C5L7G6_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol 25-hydroxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR020590</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG679899">
        <property type="protein sequence ID" value="EER07428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002775612.1">
        <property type="nucleotide sequence ID" value="XM_002775566.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER07428">
        <property type="protein sequence ID" value="EER07428"/>
        <property type="gene ID" value="Pmar_PMAR020590"/>
    </dbReference>
    <dbReference type="GeneID" id="9041172"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="124"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER07428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="255" mass="29511" checksum="BE5E305D72CCEB31" modified="2009-07-28" version="1">MMVSTTDLPSPPEVLLQGVWDEVRAVDQWGDMHVVSHIIFPSIWASVAFVLVCLYFTFFYDIPRMMRTKIQPSKWPTTRDIIIASIPQTTIYVVMNGFLFYYLDTHVHLVKEAPSLLQFTKELMACLVVGDFCIYWYHRWMHAVPFLLRNVHGVHHGYRAVYSWAGGILHPMEDICVVACNIWYPWLFQCHWLTVNAFTFIWTLNLIEEHSGHDVWWAPYNLLPFNLGGGAAVHDLHHSTNTHVYPGHGLEASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>C5L880</accession>
    <name>C5L880_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR015445</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680063">
        <property type="protein sequence ID" value="EER07036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002775220.1">
        <property type="nucleotide sequence ID" value="XM_002775174.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER07036">
        <property type="protein sequence ID" value="EER07036"/>
        <property type="gene ID" value="Pmar_PMAR015445"/>
    </dbReference>
    <dbReference type="GeneID" id="9059451"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER07036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="448" mass="48437" checksum="8AF94182B87D1623" modified="2009-07-28" version="1">MPTSVKVCNDSDTSPVADTTSSTGAVCKEMEEGISLRAFIAACGNSVITQALSIPFMFTTAGWVSFVTQALAVCLAFVCIQMLRTSLNNEKVKEYAELKGVPKFEREYTFLGEFCAGKFGRGATTLLIFLQYFLILITNLGAMGVCAALFIPGRSSVTCIIIVSAISLLMILLPWLKEITSILGILAIIGIIGSMATWVGSAFAILPDSHVVDNLPVREPAFINLVTAFSLSMWTSADLPSLVSYLGSVKGASDRSVTWTLLICLILSVVYVYIIGVAGMQICDGVCDDFYPASLHSASVVPSYLKYGLYTFILLRMFSIMLVIMVPLMVACETAVGRLLTSIKLTSGIGRLRAWRFVVRILLVVAAALGAILVEDELAYSQAVASTLLTLCSLYLWPLWFYACIVRPAGLKLWVVYLSLVLLVAFIVIGTYTSIMGFISRSTASESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>C5L8A8</accession>
    <name>C5L8A8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane associated RING finger, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">Pmar_PMAR015476</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680063">
        <property type="protein sequence ID" value="EER07064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002775248.1">
        <property type="nucleotide sequence ID" value="XM_002775202.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER07064">
        <property type="protein sequence ID" value="EER07064"/>
        <property type="gene ID" value="Pmar_PMAR015476"/>
    </dbReference>
    <dbReference type="GeneID" id="9059446"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-CH-type" evidence="3">
        <location>
            <begin position="185"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="362"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EER07064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="588" mass="64729" checksum="334AF0B7C04836C2" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C5LAI2</accession>
    <name>C5LAI2_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR006248</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680729">
        <property type="protein sequence ID" value="EER06438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002774622.1">
        <property type="nucleotide sequence ID" value="XM_002774576.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER06438">
        <property type="protein sequence ID" value="EER06438"/>
        <property type="gene ID" value="Pmar_PMAR006248"/>
    </dbReference>
    <dbReference type="GeneID" id="9065550"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER06438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="171" mass="18674" checksum="CF89C948455911A2" modified="2009-07-28" version="1" fragment="single">SLMSAEVVSLSPTSESECSIEMPSRDHSSSAPPPPPSDNELSWGQRIKRWFNLNFVLPARSLEKMDLGSALILGFWFGIFPIPGTSTALLGAFLVVFRRSRWTKWCPNAPQSTIALGVNLLCTPLCIALIPAWLRLGGLSLCPDDNSCLNKVHWYLLGDSQAASRTLSSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5LCE1</accession>
    <name>C5LCE1_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR011652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680918">
        <property type="protein sequence ID" value="EER05622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773806.1">
        <property type="nucleotide sequence ID" value="XM_002773760.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05622">
        <property type="protein sequence ID" value="EER05622"/>
        <property type="gene ID" value="Pmar_PMAR011652"/>
    </dbReference>
    <dbReference type="GeneID" id="9042599"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER05622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="271" mass="28097" checksum="6600A0820F9BFF6D" modified="2009-07-28" version="1">MCKYRSPSSLAGSSSVISASHSGSNNSGKHGNLGTRNTCEVPGCGRVPRKSSNSSRARFCTRHGGGRPCQYPGCQVAARGLLGFCYRHRHYANSSAYGNGVDGKVMPSPTPEATEDEVRASRLETYVPVPSCVDSAELTALTYIASTLKASQAAASTTDDDNTTTAGSNASPLATPTSSHSISSSQSPILTSGQRALIETPTSLVTTTSRATEAAFAAHSSAACDIDELFSIPTIPFTICKPALAAACGPLGEAPCPMDIQREEAVMARCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C5LD78</accession>
    <name>C5LD78_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyadenylate-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR027835</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG680969">
        <property type="protein sequence ID" value="EER05210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002773394.1">
        <property type="nucleotide sequence ID" value="XM_002773348.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER05210">
        <property type="protein sequence ID" value="EER05210"/>
        <property type="gene ID" value="Pmar_PMAR027835"/>
    </dbReference>
    <dbReference type="GeneID" id="9041098"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER05210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="120" mass="13475" checksum="62E0EC2699F70C7E" modified="2009-07-28" version="1">MSYNTTQDALKHFFKCVKDELSSIRLLTDKKSNQSRGCAFVEFSGPGAMKKALAMTGSELNGRKLRIEPSAAGGGKSTKRMQRINRNKKVVEREIKKKRKVWAAKKKTEKESADVHKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C5LH71</accession>
    <name>C5LH71_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR017294</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682011">
        <property type="protein sequence ID" value="EER03880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002772064.1">
        <property type="nucleotide sequence ID" value="XM_002772018.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03880">
        <property type="protein sequence ID" value="EER03880"/>
        <property type="gene ID" value="Pmar_PMAR017294"/>
    </dbReference>
    <dbReference type="GeneID" id="9044476"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="PTHR10026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER03880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="485" mass="52409" checksum="2B1D931E55AC6095" modified="2009-07-28" version="1">MFVNVDSPPKRPPGAPSEECDTLAHTHRPQCSQGRQESPDTSLLSRAPIVMCGGGLSVLGGLVPLSAGSCGSHSPVTGGGEYSSSPVISPHGPPGFASSQQSTCSSSETYKGLLLFSPDALRVASPSRKDKVTDATEDRAVVRHADFVDKVCQRVWTDYCIPANRNGIGPDDFAEIRATAMWYCHLFYAVHSLKRYGWRPVVLAATFLAFKSCERSPIRLRMNQLLDCYEKLERQSRYTSQRALQKMAQDVCEMEEAIMCLTGFEFDLNLPHKHVGSIVKSVTGDGELRKRLQQKAVAFLNEAFRGRSVLFYPGDVLAFAAVSEAAAAVLERDSASAVDIRRKLQLFRPGFDVAAVVAAMHSHEHPVARRRRADSSSSVSGNQSGSSVAACSPSAAVEGTSLRFGSQASTAAISTPMKRKRFDEEPSSEPSTLTALDLALSREMPPAQCTRAAIARRRMLLMGGEAGGNTRGENVRDSGIVLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-08-12" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C5LHH8</accession>
    <name>C5LHH8_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM domain and HD domain-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR009356</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682041">
        <property type="protein sequence ID" value="EER03828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002772012.1">
        <property type="nucleotide sequence ID" value="XM_002771966.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03828">
        <property type="protein sequence ID" value="EER03828"/>
        <property type="gene ID" value="Pmar_PMAR009356"/>
    </dbReference>
    <dbReference type="GeneID" id="9044249"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="228"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER03828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="698" mass="78456" checksum="D18856A51B8ECDD7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C5LHP9</accession>
    <name>C5LHP9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ankyrin repeat and ibr domain containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Pmar_PMAR022952</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682149">
        <property type="protein sequence ID" value="EER03654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771838.1">
        <property type="nucleotide sequence ID" value="XM_002771792.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03654">
        <property type="protein sequence ID" value="EER03654"/>
        <property type="gene ID" value="Pmar_PMAR022952"/>
    </dbReference>
    <dbReference type="GeneID" id="9048072"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="PTHR11685"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="251"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EER03654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="650" mass="71986" checksum="3F756EE3FAF92E65" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C5LHQ0</accession>
    <name>C5LHQ0_PERM5</name>
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        <submittedName>
            <fullName evidence="9">Ankyrin repeat and ibr domain containing protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">Pmar_PMAR022952</name>
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    <organism evidence="10">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682149">
        <property type="protein sequence ID" value="EER03653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771837.1">
        <property type="nucleotide sequence ID" value="XM_002771791.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03653">
        <property type="protein sequence ID" value="EER03653"/>
        <property type="gene ID" value="Pmar_PMAR022952"/>
    </dbReference>
    <dbReference type="GeneID" id="9048072"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="PTHR11685"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="252"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EER03653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="651" mass="72115" checksum="D433C6DA683A46E3" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2020-04-22" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>C5LIC1</accession>
    <name>C5LIC1_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR017939</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682213">
        <property type="protein sequence ID" value="EER03537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771721.1">
        <property type="nucleotide sequence ID" value="XM_002771675.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03537">
        <property type="protein sequence ID" value="EER03537"/>
        <property type="gene ID" value="Pmar_PMAR017939"/>
    </dbReference>
    <dbReference type="GeneID" id="9047781"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002952443" evidence="1">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER03537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="250" mass="28044" checksum="650BDE9162046882" modified="2009-07-28" version="1">MLASSPIIVLLLVSLLSYARRMVSISSQEWLAPTDTICEMFSMGVSKFLLESTTLANDGSVFSEVVNVTMVNEIVDCARKYGTGAALLLGTDSYPYHECSPDIFSFATFESQIQSYITQYNVEEVRFWVWVGNCQQFFWQIAQRVGWIISRKLKTTSGKPVRASIGFGAEPLDSPLWKYVEAARLGRLFDTVSIHFGHPTLLSNNMVDADFARQAVQRLLTLGVPASKIELSRLWDTHLANFNLPLLMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>C5LII0</accession>
    <name>C5LII0_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">Pmar_PMAR014600</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682243">
        <property type="protein sequence ID" value="EER03382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771566.1">
        <property type="nucleotide sequence ID" value="XM_002771520.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03382">
        <property type="protein sequence ID" value="EER03382"/>
        <property type="gene ID" value="Pmar_PMAR014600"/>
    </dbReference>
    <dbReference type="GeneID" id="9047470"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="287"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EER03382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="598" mass="64649" checksum="DA15430C2E06FE91" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C5LIJ1</accession>
    <name>C5LIJ1_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent Clp protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR014611</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG682243">
        <property type="protein sequence ID" value="EER03394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771578.1">
        <property type="nucleotide sequence ID" value="XM_002771532.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03394">
        <property type="protein sequence ID" value="EER03394"/>
        <property type="gene ID" value="Pmar_PMAR014611"/>
    </dbReference>
    <dbReference type="GeneID" id="9047481"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="341"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="627"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="6">
        <location>
            <begin position="781"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EER03394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="894" mass="96966" checksum="42FAED636A6427C4" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C5LIK7</accession>
    <name>C5LIK7_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR014625</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682243">
        <property type="protein sequence ID" value="EER03410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771594.1">
        <property type="nucleotide sequence ID" value="XM_002771548.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03410">
        <property type="protein sequence ID" value="EER03410"/>
        <property type="gene ID" value="Pmar_PMAR014625"/>
    </dbReference>
    <dbReference type="GeneID" id="9047572"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012813377" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="119"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER03410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="347" mass="39360" checksum="B95649D8F38A588A" modified="2009-07-28" version="1">MSLIFCFGCISLCGCRECVVRPLTFYPPRQSGYGVIAPNEGAPLKCKKKRWRKNNDPYGPTKLIIMLRDDRKKLSIRVSDVLSLHCDGKLSCDHVLFPGDINGFYFKHSTEVNPDRWTIIFSHGNSTDIGYSWISYYYLARHLKVDLIAYDYPGYGLNGGKPSESNTYTTIRAVYDFAISSMGIPPSNIILYGQSIGSGPAVDLYTKVHVGGLILHSAIGSGLRVYKSYERPRRTPWFDLYRNVEKLSDYFAEAGKSPPPIFIIHGTDDEEVPYEHGMLLAETITGDKDRRCAPGTTALYPPWWVKGGTHNDIETRYRDQYYKRLKAYVRYLKMSPRPDLSTLLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C5LIY4</accession>
    <name>C5LIY4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiolproteinase SmTP1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Pmar_PMAR000556</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG682245">
        <property type="protein sequence ID" value="EER03319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771503.1">
        <property type="nucleotide sequence ID" value="XM_002771457.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER03319">
        <property type="protein sequence ID" value="EER03319"/>
        <property type="gene ID" value="Pmar_PMAR000556"/>
    </dbReference>
    <dbReference type="GeneID" id="9047329"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018640563" evidence="2">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor_I29" evidence="4">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="112"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EER03319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="337" mass="36607" checksum="6A3C818976642BC2" modified="2009-07-28" version="1">MTTISVVFLLAFPVYKAVDLETSSLAFIGFQKKHGKSYDNKDEEMKRAAIFHDNLNYIEEVNAQNLSYKLGVNEYTDLTLEEFAALKLSSTDMSEGMGDGFVAGAGPTTTTLPTSVDWRKKGVLNPVKDQGYCGSCWAFSAIGALEPRYAIATGKLLSLSEQQLVDCAGAYGNEGCNGGLMDKAFEYIKATGVDKESTYPYVGSDETCQATVENKTDGLPVGEVTGNQMLHQTEKALMEGVAAAPVSIAMYANLQSFQHYKSGVYSDPNCNAKGGSIDHGVVAVGYGTENGQDYFIIRNSWGRSWGQDGYVYLKRGVGSFGQCNIYKYMCVPTLKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C5LK60</accession>
    <name>C5LK60_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">Pmar_PMAR026004</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG682743">
        <property type="protein sequence ID" value="EER02847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002771031.1">
        <property type="nucleotide sequence ID" value="XM_002770985.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER02847">
        <property type="protein sequence ID" value="EER02847"/>
        <property type="gene ID" value="Pmar_PMAR026004"/>
    </dbReference>
    <dbReference type="GeneID" id="9051186"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="Pentatricopeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="638"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="709"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EER02847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="941" mass="102911" checksum="353A48DFD65949C7" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5LN26</accession>
    <name>C5LN26_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">Pmar_PMAR028276</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="GG683700">
        <property type="protein sequence ID" value="EER01826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002769108.1">
        <property type="nucleotide sequence ID" value="XM_002769062.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER01826">
        <property type="protein sequence ID" value="EER01826"/>
        <property type="gene ID" value="Pmar_PMAR028276"/>
    </dbReference>
    <dbReference type="GeneID" id="9040434"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017066">
        <property type="entry name" value="E3ligase_BOI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="PTHR22996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036836">
        <property type="entry name" value="RNase_bind_SBP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="368"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EER01826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="434" mass="48010" checksum="84D0C19D472D40F6" modified="2009-07-28" version="1">MGNSSSRRGRTQSPQHSQQEAEQQHQQEQQSRPRRQGTSFSLWPTVSWMGISRPTMRDTTNSTQQQQQSSIVVQSRQRPPAAAYQQQQRPVYVFRGGRYVPDPTADPRPYQAPFSPFSLVQTIPEIKQTCVVKNPCNLRKDTIKFIEDGTNTPPKLCFMVDTTTPCTVRLHYFVVGDASSHTTDIPEIKGVRTYTYDLPHAGLRQKIITNDEVQRIDRRQPLPAGWSSTAYTKGSHRYPAVVEIMSKSNSNGNSKDIICTGQLTYLSFPPVEGTELMMNVKVLKQRVLFSTQAYDMHDIYGIEAPQSAVHEVVEQIGDTVEGKIVKGGGNSPSSSSEEESINGEAAPSPSHPSPGHYDDEADAMASECVICLSEARTTVVLPCRHMCLCNDCAVRVQEANPGHVSAKCPICRQPVTSMLQIAASPSSIIRESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>C5LPG4</accession>
    <name>C5LPG4_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR009772</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG684148">
        <property type="protein sequence ID" value="EER01373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002768655.1">
        <property type="nucleotide sequence ID" value="XM_002768609.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EER01373">
        <property type="protein sequence ID" value="EER01373"/>
        <property type="gene ID" value="Pmar_PMAR009772"/>
    </dbReference>
    <dbReference type="GeneID" id="9039851"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EER01373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="207" mass="23658" checksum="177B36F4F06203B7" modified="2009-07-28" version="1" fragment="single">KSRRKQIDFKGVALVNALLSMRLQYSKQGKMAYDNPPAPRRITKPQYEKMNLEALQCINFATLCNQGQAKRDCDRAYTACQQSTVISLPKEVSIDMYDVREVCQNQVPDHCRPYADVERFLNKPEVKKSFGVDPAFDYKRYNPKVDEAIRRSPGFYADSYQTLGPLMDNNALKVTGYYLVSRLSVNGSTTTFTLARLHPHAFILAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C5LUJ9</accession>
    <name>C5LUJ9_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxypeptidase Y, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">Pmar_PMAR028750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG685501">
        <property type="protein sequence ID" value="EEQ99595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002766878.1">
        <property type="nucleotide sequence ID" value="XM_002766832.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ99595">
        <property type="protein sequence ID" value="EEQ99595"/>
        <property type="gene ID" value="Pmar_PMAR028750"/>
    </dbReference>
    <dbReference type="GeneID" id="9051359"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="PTHR11802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ99595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="367" mass="40850" checksum="127319F3994E9F93" modified="2009-07-28" version="1">MGDMLWTRFFFWFFESRNDPATDPIFLWLEGGPGASGTASAVGYNGPCMVNKKGTAASNNPNSWTNKANGIWLDQPTGVGYSKGGPPEETIGETVKNIYSFLRAFFSRFPKYKGPFYLIGISFAGVLLPQIAHALKQGSEPPISLEGIIFQNAMINAEAQFPLYPEMAFHSKTAAPAITKQQYDQMKREMPGCLKEIQNCNRKPNVCRVAHEQCQELSLNPLVSNGVDFYKLTTKCPHPDRAGCNNEEDSPNVDSFMQLPDVKTFLGVSEEFVIDNDEVYNQLVPFVLLNSDSFLPGLLQSGVRVLTVAGDLDYICNFMGLKTWMLDLDWPGRDAFRSARDVEFKVRQSKGRISIHSDPGQILPGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C5LYS1</accession>
    <name>C5LYS1_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein ERD1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">Pmar_PMAR002374</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG686832">
        <property type="protein sequence ID" value="EEQ98095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002765378.1">
        <property type="nucleotide sequence ID" value="XM_002765332.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98095">
        <property type="protein sequence ID" value="EEQ98095"/>
        <property type="gene ID" value="Pmar_PMAR002374"/>
    </dbReference>
    <dbReference type="GeneID" id="9040529"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033507">
        <property type="entry name" value="Syg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF4">
        <property type="entry name" value="PTHR10783:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="527"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EEQ98095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="637" mass="73988" checksum="FDA69913AD56470D" modified="2009-07-28" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C5LZ42</accession>
    <name>C5LZ42_PERM5</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein white, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">Pmar_PMAR016129</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG686838">
        <property type="protein sequence ID" value="EEQ98051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002765334.1">
        <property type="nucleotide sequence ID" value="XM_002765288.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ98051">
        <property type="protein sequence ID" value="EEQ98051"/>
        <property type="gene ID" value="Pmar_PMAR016129"/>
    </dbReference>
    <dbReference type="GeneID" id="9040477"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="191"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ98051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="455" mass="51565" checksum="206E2F8FA5E56880" modified="2009-07-28" version="1">MLEYLRLTSCQTTMVGNQLTRGISGGERKRTSIGVELITQPSMIFLDEPLTGLDSYAAVTTSRILKGLARLGVTVLMTVHQPSSEVFELFDKVMVISEGEIAYHGLRTSLSDFFIKHAKLTCPPHYNLADFTLYTLQTERPEVIAGLVQAYKAEISDGRDANGSTLEKDVPDGAAHTRNIKPPYRAGLHKQFHMLALREFKAVMREPSVFIIRYIVVLFTTLLLGCIFHNAGRPGSELFWLMNVRLFQPYFSAVVMMCLMQLFGPAQTAIIRYPEQRMVFLREYTSGMYSVIPYVVSKTMVELPLALLECFLQVVAFYWIVNLQGNFVLWLLLLWLLNLVSTSLAQLLGATTSTITRAMQLMPLLFMPQIAFSGLFISLDRVPVWLRWGQYISYLKYGVNLGYFIEFGFDMPTLAKMNSIYANLLGLDIGVLLGMLILFRILTIVVLRRKARYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C5M050</accession>
    <name>C5M050_PERM5</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">Pmar_PMAR007475</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Perkinsus marinus (strain ATCC 50983 / TXsc)</name>
        <dbReference type="NCBI Taxonomy" id="423536"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Perkinsozoa</taxon>
            <taxon>Perkinsea</taxon>
            <taxon>Perkinsida</taxon>
            <taxon>Perkinsidae</taxon>
            <taxon>Perkinsus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="El-Sayed N."/>
                <person name="Caler E."/>
                <person name="Inman J."/>
                <person name="Amedeo P."/>
                <person name="Hass B."/>
                <person name="Wortman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 50983 / TXsc</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GG687015">
        <property type="protein sequence ID" value="EEQ97627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002764910.1">
        <property type="nucleotide sequence ID" value="XM_002764864.1"/>
    </dbReference>
    <dbReference type="EnsemblProtists" id="EEQ97627">
        <property type="protein sequence ID" value="EEQ97627"/>
        <property type="gene ID" value="Pmar_PMAR007475"/>
    </dbReference>
    <dbReference type="GeneID" id="9036828"/>
    <dbReference type="OMA" id="KICMLDH"/>
    <dbReference type="Proteomes" id="UP000007800">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ97627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007800"/>
        </source>
    </evidence>
    <sequence length="247" mass="27469" checksum="A48A36AD6424EBD4" modified="2009-07-28" version="1">MSGYDRAITVFSPDGHLFQVEYALEAVRKGTTAVGVRGKDTAVLAVERKAIPKLQDPRTVRKILRIDQHVMLAFAGLNADARVLANKARVECQSYRLNVEDQPTVDYVARYIAGVQQQYTYKGGARPFGISTLIIGQNEQKKPQLYQTDPSGSFNSWKAAAIGRNSKTVSDYLEKNYKEDMSEQETIEMAVRALLEVVDSSGKNVEVCLMKSDGTLVMLEETVVEDLCKSLDEGIEKGRTQGQQQRV</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>