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<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TTZ0</accession>
    <name>A0A179TTZ0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase family hydrolase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_00134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99313">
        <property type="protein sequence ID" value="OAS99313"/>
        <property type="gene ID" value="BDCG_00134"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00134"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="3">
        <location>
            <begin position="167"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="391" mass="42740" checksum="91B1063AFF6690F5" modified="2016-09-07" version="1">MADSSDLNLDAPSDLQDLPDLSMELIPPQEGTYPDRASLLAAVQAHGKAHGYNIVVKSSSTPTEKKPGRVAKVWLRCDRGGQYRPRNGLTEETRKRRRTSRLMDCPFMLVAAGHPGIWTLTVLNPSHNHGPIVEKPRQNPHPKAKKGQVTATPYDWPHDASFTPFTTALVLIDMQRDFCSPGGYMAYQGYDITPAQLLIPKLQRLLDAFRSAGFPVYHTREGHRSDLSSVSNRESFRSKNNPSGMGIGSDGPLGRLLIRGEPGHDIIPELYPTMGEPIIDKPGKGAFTYTDFELLLRNKGIKNLVLAGVTTDGCVSTTMREANDRGFDCILLEDGTSAADPSLHMSTVESVKMEGGVFGATAKLDDMIQAVENFKAVTVKKLAPQMSNVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWA6</accession>
    <name>A0A179TWA6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99348">
        <property type="protein sequence ID" value="OAS99348"/>
        <property type="gene ID" value="BDCG_00230"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99349">
        <property type="protein sequence ID" value="OAS99349"/>
        <property type="gene ID" value="BDCG_00230"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00230"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="115" mass="12956" checksum="F4532FD881E8A475" modified="2016-09-07" version="1">MVLTTWRRLICAVDHSYPEIDISFPHAKTPPDSSGFQLKSKLESSPKWQIGQDVHCTYIHTAESNSSVLEEPTNICVMHAQNAAITLKPEEPPPRILPTYPKSVSVQSHRQNYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWB8</accession>
    <name>A0A179TWB8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc metalloproteinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_01140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99732">
        <property type="protein sequence ID" value="OAS99732"/>
        <property type="gene ID" value="BDCG_01140"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01140"/>
    <dbReference type="OMA" id="RMTAYMW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="751" mass="83010" checksum="6CD346AB6A9D38E3" modified="2016-09-07" version="1">MPISSDAFNIDNLSQGETVYQRCIVIKGSCRSPVESGFLTVENQGASGSQNFPTQRHPVLQRRFTFLAMLSEGPNNLIIQLGSHYNRPALSPSPDTIIVSLNYYPLMNSPPLHLAIMVAKDSPLLIDCPPDKHGGLPDGHSHLDAVIAKFRITAYMWQALTAEDMRLKGLGRRSFRLEEERTADTTSQAFLDNRGRQWLPVSEAIRSTAKIHLIGTHKTVTELRDPNIAQQNRHANDKNRLFNIFLDALKDYGPPFDAPNHPIVAGLILDSHYSVEQNLIVAHAALGAHNGDGISLGMFGSHLTYSWPRFAEEINEYLLDTRAPGPTLGNDCGECDSMWEACSIGQGAFLHEVGHAFGAPHTTGIMARGYAEHWPRNFLPRTAYSVANNRQGVVVVEGQTRNNARWDLRDALSFKLFPHFWIPGDGIFEPGVRAETPSAVVIEQGEGGPSKLGIQLSCRAKVVQISFNDNPEPSPTVASPSNKVIYMMKDLESRFPRNSKKPLKLTVLGMNGKTRTIHDVWRLFGFRDIIRIPGSKVVLTKQSILCPQMEADQSKEPDDSSVWAWATLLAKPRDGLRSGFGSTKRVKSIDVRTGAFLDGLYVDFDDGERVNCGPRLKRNGGKHTFGGHAARQIDIIPSGSGNRVGSYADREIVMIEVARANNVITGMRIHLRDGTEGGELSGYGCVDETCTLEPPPGQRIVGFYGRNWWGQMCDAMFEFGVISAPRDVELPETVYGMKELMNTDGRRNDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXA1</accession>
    <name>A0A179TXA1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TatD DNase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_02900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00486">
        <property type="protein sequence ID" value="OAT00486"/>
        <property type="gene ID" value="BDCG_02900"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02900"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="386" mass="43342" checksum="DEB63A852AD5FB0C" modified="2016-09-07" version="1">MIQSHSLRTLYVGLIRAGKPFRYTLLPKARTYSVLSSHHNLLLRYDSIRNCVNTPTQNYFPSRRSEVTLASMGESIKQLRYADVAINLGDPVFTGVYHGKKVHENDLDDIIQRALDVGCQKLMVTGSDLDESRHAVEMAKAHPGICYATVGVHPCQAKLFDSYREGPEKMLEELRTLALEAKASGHAAAFGEIGLDYDRLFFTPKDQQLKYFEAQLDLAVEIQLPLFLHSRAASEDFERLLTPRLAKLPKGGLVHSFTGTMEEMQRLVALGLDIGVNGCSLKTEENLEVVKAMPLERIQIETDGPWCEIRPSHASYKYLEGAPPLPKSFKKERWQKGCMVKGRNEPMAIYQVAQVLANLKGISVEEVCETTWQNSIKMFGLGENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXB3</accession>
    <name>A0A179TXB3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99697">
        <property type="protein sequence ID" value="OAS99697"/>
        <property type="gene ID" value="BDCG_01073"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99698">
        <property type="protein sequence ID" value="OAS99698"/>
        <property type="gene ID" value="BDCG_01073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01073"/>
    <dbReference type="OMA" id="CANERYR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="523" mass="58884" checksum="D672570F99BEF440" modified="2016-09-07" version="1">MPCLVSLEPSRKRQKPDDDLEQSQHQLKRLKLGGPPPAYWDNLSRIWLTKDTLREFNRRNSPSNRIVESGQRPCRPLTRQLHATLKNRCQIPALDPLSGCKPESLKEIKRLSRRGGPDLSDLRNFPDPRTPFYQSMSTSSSGRRKRRAGSAPDDSDNKATTKTTSTTVYNRNFQQNLVDHGVYPPGYKYPNGQKLAKPNNWLELNERLAQPQASLSPSKFSEQEFEEFREADMNASKEKPIVRLAIPIIEGHIDDVRCMGGDYPFGNFAPLTDGTLANAKPDHFFGARPEQLNHQIRDELSDFIIPSTQKDHPIAPNFFQEAKGPDGSPAVATRQACYNGAVGARGIYKLQSYKQDEPTYNNKAYTITSTYQAGQLKLYTTHPTAPRESDGRTEYIMTPLRSFAMTDNPDTFRSGACAYRNARDWAKERRDEFIKSANDRHTQARSELLSTSEREATSEPTIILEDSDTSATFDEAEFHDAAQWSFAHTNDSADDPPASTKHTKRARIGASSISRASSKSLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXC2</accession>
    <name>A0A179TXC2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_02928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ER-3</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002627943.1"/>
    <dbReference type="EnsemblFungi" id="OAT00505">
        <property type="protein sequence ID" value="OAT00505"/>
        <property type="gene ID" value="BDCG_02928"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00506">
        <property type="protein sequence ID" value="OAT00506"/>
        <property type="gene ID" value="BDCG_02928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02928"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QYWNNLT"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase_Ca-bi" evidence="6">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT00506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="701" mass="80854" checksum="2F8280A4DC43AD04" modified="2016-09-07" version="1">MNEGTPLIVPRGFSHAVHELRKSSSIPALPKKILVPRTRRGSHDEGSLPPVFKVWIDDAMKSLLDQEDTDKNLQITILDNGPKVISLGTLLSDGGRTREIRGTYLLANLLEELHLTKGKHASKLIHFSDVSEDPVSRINRKIKDEYWNNLTRRLDESMIEAAAPDPKDWNENPRPRIFVPYGEGRLYDYYCQVSKNKPELKLEVQYLPQGEVTAEFVHGLRDRPGLLALEMDYSNPDKLRGLQFIVPGGRFNECYYWDSYFACLGLLEIGRIDLVRDILNNFIFQVKHYGKIPNANRSYYLCRSQPPFLSDLAVRTFQGMNNKEEAAEVLRSGILAAIKEYFTVWMSEPRYDPTTGLSRFKPPGKGIPLEVEEGHFDAVLYSYAEKYTCTIPEFINQYNSGNVNEPELDEYFMHDRGVRESGHDTSYRFDQGCADLATVDLNCLLYKYETDITWAIKTVFNDKLPIPAEWRTTDMGDDHVETSASWLQRANQRQERANKYLWDPEQGMYFDYNTRTHKRTTYEYVTTLYPLWCGIASREQAESLLARALPKFECVGGLSTSTEQSRGPVSMPHRPPKQWDFPFGWAPHQMLAWDGLKRYGYLHEMERLVYRWLQLMVRVAVNYHGAIVEKYDVTQLDNPSQVDAEYGNQGLDFKYANIEGFGWSNASFSYGLSLIKHQKLMVKALGLCVPYDDLRMERVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXD0</accession>
    <name>A0A179TXD0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_00123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99300">
        <property type="protein sequence ID" value="OAS99300"/>
        <property type="gene ID" value="BDCG_00123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00123"/>
    <dbReference type="eggNOG" id="ENOG502SKTA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTIATWE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAS99300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="801" mass="91918" checksum="F3D932A2B0054759" modified="2016-09-07" version="1">MSWSYRAAYPKLSTLLEQTSLENKLRCRVNFEELTIDTDRYVLRKLSYNEAHAPLSVIFDSLREISSQTTGESHSVKIKGTALVKRFVRILQLTDISPLVLNCIFGTTSSLDISHVAAFVDRNLNGLNWAKVNLLQTRNTGWSSYVYEYHFSFYFVTLDYFEPDTVKPDPRKIRRSCSFGKRKGTKHRYIHEETVSFLLCGHFDDAFTCYQLGDTYFKPRYTKDTGPRFFRSYDPSQSPGQLLLHWIAVALFHARSRWENAIDSLQSEIRAPSDVVFMEDRSDLMADDPQFSLSKTYFWALQTYKLFERTLEQTITTWETFKIDSLPKIQDGRISPENWDASVSSIDQSIELLKPKIDRIKRGMQDVRDLRESLQSTAAVFDSRTAVRQGENIRLLTYITLLFLPLSFGTGIFSMQLIEPSATTINAFAITLPVITIVSALLIFNLNSLTAAFDSVVRKATFGLQRQMRLHHRKEWKHRALALHQDDISTEPPVRKASKESSHWVYILFLIETAVVVTPVSELNAALNCYGLFGFEGEKAGEGEDDEYSDNEDASTHQPRKDRQKEVLMRVKRAAREAEEQERKRKDEESGMAIGLLRRFYRYIGHLGRVLGHTVLTSFRILLLPIWVVLLLVEYILTVLTLTLLFDQPPYQANPSSATHGEESPESHPSSPFARAWHALGLNTLTLPTRHHHPHDLSYCPRLLETQSHEHALSRIQSEEQAPRLIKLPALQRPAPAITNNERREARHTAKRRGEHSPERTLDRISNVEVSVFDPARSRRTARSRISRAVNAARYEAGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXD4</accession>
    <name>A0A179TXD4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING finger domain-containing protein, variant 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_02875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00465">
        <property type="protein sequence ID" value="OAT00465"/>
        <property type="gene ID" value="BDCG_02875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02875"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="239"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="405" mass="45160" checksum="78772092EF78D26C" modified="2016-09-07" version="1">MWKTTNRYPVYAIPGVYGASVMRALSEYSGSVADAPYAEDLLRRFQGSDVVRVSSKIAISKNSTGGLPSLWIFLLVVVAILICIALFSSIAMRCIQARQLRSLERRVAAGEVDLETLGIKRLNVPQDILDKMPLYICNGSGRIERLIPPTTEMTPESIDEPSKLPPDKGSFLQSISGWKWISRVSQAFYSRKSRSTTPPPPLSSAPDSGTSLPSPRSQTTPIDNNQQHHAEPTFAQTTCPICLDDYDWGETTVRELPCQHIFHPECIDNFLLQNSSLCPVCKKSVLPRGYCPEKITRVMVRQERLARRARPPQTIEIGNGGYDAAMPTSLGNGNQSPQNRSRTGPQATVSPPTGERFSRQRQEEMRMRAVAMLGYRPMIADEERAQDASRSKLRKLLQILFPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXD6</accession>
    <name>A0A179TXD6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99707">
        <property type="protein sequence ID" value="OAS99707"/>
        <property type="gene ID" value="BDCG_01099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01099"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1032" mass="113877" checksum="A67BF8EFF09F256F" modified="2016-09-07" version="1">MDAAAKGGRVGLNWYVSQIQRSALFLRMTMNSAASRLRPSASEVSITSRWCNRALRPLTSTILRLEKHWKITPLGAPNLNGTTVSGSSQKSNSAAKGARGASESDSESTPDDPTWVPGGAVRKHIRHKYSARTGSRSRVVVRSPETLKLQPGEFSIPTPLIKGKKRQCPEMEEPNGDASGVAAIADSNEDSSTQNSRRGPMKRKLPAYAGWNSQRIWKDSCNEYNDPSYIAIAQGIFQVWDTFLTMTAPEKSSGPGARSLMSMALGTTSMYIASEQEAVDNCEDKNEKVDVADLIFTELESIYGISNAGWKPLKSLVRLHGIRLVCDAIRHRWISPMIARQLVLNSIDSVSYDAAQEILSALLSVTQSIEGPRHLDCSLFSSGSFGVFHTLATYVNKASHISFFFREVGSLLRDGIVPVEWIVTESMKPFVTHALRSISCEDDDCSASVLFIVNTILAASRSNTRCSLPTLELAADTDKLQKCDEGRCKLDSSRRNLPENPESKANEHLSLALNNSISSILGILYSAHIVRFTTHSPTFVPSASPMHHILVRVSAIIQHDILDASFDLAQDRPRSELLRVGHILMADYILKCSWEGAKKEGQTAVPGATKLLSTFEYFTRTLKSRKDLTASLSTFVTHVSHSCGRALSEDGFTQLQIFTDALTEDNLQPYPALKALLGKVAVDAALKFAESTLHPDHHSWAAHIQTKAARYSNGPLGHDEIIPLTPSLALSKTGYIWEESIGEWIAAAPASGAYRSLRAYDATASRGSSTFSACSEGYNSSITSSEFTSPSWSRKRKRGVNSPNLVSGKHARTTYSSSLKAPPRRLRSGKSRSWSFYIDERESHDSNLLIFDRFKRSKITKKKHYVVEPSITKTRPLCQRTDINRSLLNPATMEVRLPGPQTADKAVEVVIVHDRNKYIDTESSSFLIQEERERMLPGSDRSDYNRDYDLSDHNDDSDGDDEDVLAREPSPRYLLRRKSLCTPIASKLFSCATPPGARLRTTRSSTSLQKQPILQAAGCNIVGSSDDELSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYD1</accession>
    <name>A0A179TYD1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2 transcription factor, variant 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">C2H2 transcription factor, variant 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_03080</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ER-3</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00570">
        <property type="protein sequence ID" value="OAT00570"/>
        <property type="gene ID" value="BDCG_03080"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00571">
        <property type="protein sequence ID" value="OAT00571"/>
        <property type="gene ID" value="BDCG_03080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03080"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="643"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT00571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="708" mass="76119" checksum="666D16D933025B50" modified="2016-09-07" version="1">MDGTTATPKNSSSPHLDPSKTSSTQPSASLSSGTADHERDSGYGTVNGESEKRSISSPRVSNAASTGSPGRTHSREGSSVRSSVPEDNPGAESDADQEGGSENGAEMGESAPPSKKKKGQRFFCTDFPPCTLSFTRSEHLARHIRKHTGERPFQCHCSRRFSRLDNLRQHAQTVHVNEDIPGDSLAAQGTRFQRQIRTDRVRPPGRNRAGTVGSQGGHSRGHSRNLSTSSIGSTMSTYSQSQEIRRRPPPLMMAGDGAARTRLSLESMNEPPRTPPAQIHAFPTQSPSSALFTPASATYPAGDGGPYYYGSPSSATSGFWAERGSGRRLSFPSGTRPFEPTNTYPPAFPRPLAPSTSSYSNSGSIFGSPNAPHTPRDDSNMSSAEADWRRRTWHPSTHTGFGRPVSSGLWFNQPAERPQPGFGTNPPPRLPGIESFDQVQQRPSTPPRREPTPMQIDRPLTSSNAAPAFAPTFNTQLPTARPPPPISGPGHRRGHVSFDMSLHQNLTKLDIRGNTASNMDASHWSQQTIGELRDVASRPFGSFQRQPVEPTIHRIPDASRPPEQPATSSNSNGPTTPTQNKRHGWYNGPLPASTSTNQPANPSPEDSSSSEGVATPSASAPEYHPAIVPSHDDIERHHSHVQTEPPNNACAPQAPRAANNNSYPVHSNPESRHVFYSGNSNHPAGGMARLEALVAVATSEDKGAGRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYD2</accession>
    <name>A0A179TYD2_AJEDR</name>
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        <submittedName>
            <fullName evidence="3">CAMK/CAMK1/CAMK1-RCK protein kinase, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00048">
        <property type="protein sequence ID" value="OAT00048"/>
        <property type="gene ID" value="BDCG_01839"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01839"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="398"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
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        </location>
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            <begin position="22"/>
            <end position="42"/>
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            <end position="79"/>
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        <location>
            <begin position="540"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="618" mass="69214" checksum="6964963291D7BEAA" modified="2016-09-07" version="1">MSTIQSLKNFIRHGKQARVATPHAEPTTNVSTIHAEQQKQPQGQYPAIRGLDALDCRLPPKDASNAPGSKQTGTAANKGSRVHESEIEQIIAEERRSRSMMPKYPGLERWELVEKMGDGAFSNVYRARDTTGKFKEVAIKVVRKFEMNSKQRANILKEVQIMRQIDHPNIVKLIEFSESRQFYYIVLELCPGGELFHQIVRLTYFSEDLSRHVILQVAKAIEYLHEHCGVVHRDIKPENLLFYPVPFIPTKNPKPPAPGDEEKADEGEFTPGVGGGGIGQIKVADFGLSKVIWDSETMTPCGTVGYTAPEIVKDERYSKSVDMWALGCVLYTLLCGFPPFYDESIQVLTEKVARGQYTFLSPWWDDISKPAQDLVSHLLTVDPEKRFTIKEFLQHPWIKQTNEETHAAADAPPLATPSALHAQFLETPAAVMDRKMDFRSPGAINLREVFDVSYAVHRQEEEGKRRNNFKQGFHAPLNPLNEDFDDDNSDNDEDLEGIIYYDQDKHAANPAKVTPRAGHNPTEVATMEAKLKSTNLNATAATQPSAAAQARQREQQQQRQRQAPRQQGGGGYGTHSSTVAAAARENAARSARQPFELSLDNATLLGRRGRRLQGQKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYD4</accession>
    <name>A0A179TYD4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING finger domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_02875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00463">
        <property type="protein sequence ID" value="OAT00463"/>
        <property type="gene ID" value="BDCG_02875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02875"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
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        <location>
            <begin position="385"/>
            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
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            <begin position="451"/>
            <end position="508"/>
        </location>
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        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="551" mass="60914" checksum="DF8FCD0A2EF73B34" modified="2016-09-07" version="1">MAANAFDAVVHAIPSEGSSLTRPVPVDSSISFELSIGDKIQTLSTTNVRNGDAIRGLLYVPELDFEDPCRQATTPFILANVTRLSDIPGPRRSISLAPWVSSACTISFLAALSRNPPYAAVFYRPDESTTTPPLADHPTWDLGDRDMWKTTNRYPVYAIPGVYGASVMRALSEYSGSVADAPYAEDLLRRFQGSDVVRVSSKIAISKNSTGGLPSLWIFLLVVVAILICIALFSSIAMRCIQARQLRSLERRVAAGEVDLETLGIKRLNVPQDILDKMPLYICNGSGRIERLIPPTTEMTPESIDEPSKLPPDKGSFLQSISGWKWISRVSQAFYSRKSRSTTPPPPLSSAPDSGTSLPSPRSQTTPIDNNQQHHAEPTFAQTTCPICLDDYDWGETTVRELPCQHIFHPECIDNFLLQNSSLCPVCKKSVLPRGYCPEKITRVMVRQERLARRARPPQTIEIGNGGYDAAMPTSLGNGNQSPQNRSRTGPQATVSPPTGERFSRQRQEEMRMRAVAMLGYRPMIADEERAQDASRSKLRKLLQILFPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYE8</accession>
    <name>A0A179TYE8_AJEDR</name>
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        <submittedName>
            <fullName evidence="5">MFS multidrug transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_01871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00079">
        <property type="protein sequence ID" value="OAT00079"/>
        <property type="gene ID" value="BDCG_01871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01871"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="109"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="221"/>
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            <end position="264"/>
        </location>
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            <end position="290"/>
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            <end position="321"/>
        </location>
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            <end position="366"/>
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        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
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        <location>
            <begin position="405"/>
            <end position="453"/>
        </location>
    </feature>
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            <end position="419"/>
        </location>
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            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="453" mass="49023" checksum="80055BEFA22037E1" modified="2016-09-07" version="1">MRKNGRQFSLPYMREVCSLDRTKARQVPFIVGLLLLAGATVMFALARNLALLVVARILQGLSGAVVWTIALAMMADRVGSQEIGAHLGTIVAARSIATISAPLIGGIVYAKVGYYMVYVTAFIFLGADIVFRLVMIEARVAQKWDPSIGLQLAREHFSTQKLEGPEKVSQKEDEARAFTVAQPRGSRISRLVHYLPPFITVLSSIRLVMALWGCTVLAILFGAFEATIPLFVHSTFHWDSAGAGLVFLAVLIPTFISPAIGWLADKHGTRWYVAIGYLLTTIPVILLRIVTQNTLYNKIVFCVLLAFSGGLAMLFEVPVQIEIVLSVEEKMRENAAHYGEQGAYAQAFGLGNLTYALGLIIGPLWGGYAVEGAGWGVMTLTLGIMCCVSAVPAAIWTEGNIFKRKKKPNSGREGEGERQEVSASVGTASASNSHDTAQNRPEPDSIIVPPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYF9</accession>
    <name>A0A179TYF9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein stu1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_03901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT00944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00944">
        <property type="protein sequence ID" value="OAT00944"/>
        <property type="gene ID" value="BDCG_03901"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03901"/>
    <dbReference type="OMA" id="TMSTNGC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="320"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="598"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="822"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="907"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="711"/>
        </location>
    </feature>
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        <location>
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            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="948"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT00944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1243" mass="137058" checksum="9698F766D0FD4E3C" modified="2016-09-07" version="1">MEARATEVLAALKNPNLSIEAKTQQLTKLKSEIKQKNVPEVAISTVFEAVRHAISSQHSSLSAGGFSSLGHLLKRLYLQELHQAVAAQGRSTYPLLLERLGDHKERVRSQAAQAFSDFWESSPVEVEHHVLEVALVGKNPRAKETSMTWLATMTRNRGVLFRTYVPSLVACLEDADSGVRETAKATVIDLFQNAPPRALSDLKKQLQSHNVRKSITNSILSNIGVDQELSSSVQSQSRSDILRPESSFSSHREPQRPNSVLSVRSYSNSETANSHQPARGDLPRRDAVLSHSVSVESFPAVTGNPEIVEPETVDPLYLNSHRELDEVFREMLPHFEGRESEQNWIHRERSVLKLRRITKGNAPTDFQHNYLVGIKSVLDGILKTVNSLRTTLSAAGCSLIQDIARVNGPAIDPMVEVLLQNMIKVCAGLKKISAQNGNLTVDAIIGNVSYTSRIMQHLWLACQDKNVQPRLFVTGWIQTLIQKHGHKGSIEHSGGVDVLEKCIKKGLGDANPGVRENMRSTFWTFARIWADRAEGIISTMDAKSKSLLERDPGNPNLDANSLNTNGKPRTGMGNSGLGGWSRLTLKETIAAQKKARLAAAKKLPARPESAQSSFPDLKSSRSSIHRQPGTTTRTVPTGSHLSSQNTSLSSAPMRPSSRPRRPELMRPATADPYSSRNRPVHSTSQSKLTSPSESPQKPRSKTTSTPGRKNPTPARPKSRLDTSAPVSTAKPKPKRLDIAGLKPGEARLMAGPASKPNYTSAADAKPLAASPARSDDSLHMALPQTDNRSTEFIPTALASDAEVFTQSKSDFMTDLPTSGSLVMAHGTPLSHRRLSSSDTSVSRIPMSPSLQSKVHSEERLALPTSPSRRSSNNYDDTVPQASPAGRLSIPSIEASHPAETLKVYEDPQSPNAKENVGHPGPLGLSPRSSHSPAKAAPLEELPINEPANTPSRKYNQQQEPSGFSPSASVATPGSENLHRRWKKVEILERRRSLSPRSKDPSRGRDMVDRGLNKIRTGAIDVHGYRKVQSLIKYHESIFHDKAKYGATLMVLLEALEAPDTDRKSTTGRPMDLKTQVLVTIRLLFSMNRDYFATYNARAMTAIITARKHYELTNHIVSGLEETAEDIVQACDPADVIDAILDLLESEEKSPDSHRMISMGGYILSGLLRRLNEKNLFLSEPELERLGNFANQSLKDPQPDIRRAVMEFCLELHEMVKPEEAFWRTITEEHRPLLTYYIVRKPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZE5</accession>
    <name>A0A179TZE5_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_16769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ER-3</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002627215.1"/>
    <dbReference type="EnsemblFungi" id="OAT00833">
        <property type="protein sequence ID" value="OAT00833"/>
        <property type="gene ID" value="BDCG_16769"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00834">
        <property type="protein sequence ID" value="OAT00834"/>
        <property type="gene ID" value="BDCG_16769"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16769"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="SSF101233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="543" mass="63072" checksum="9BE7C4F5444C0395" modified="2016-09-07" version="1">MATTAEAKLIRQTKFPPEFAKKVDMQKVNIEVMKKWIAGKISGILGNEDDVVIELCFNLLEGARFPDIKLLQIQLTGFLDKDTPKFCKELWNLCLSAQTNPQGVPKELLEAKKLELRQEKLESERLAEEARRRREEERARERELEALRERERAERGRGRGRNRWADRDARSPPRRRSLERYRDGFGRRKADTWAPSGGRSSRWTEDRGRRASRSISRSVSRSTSRSSLSPSPHRRDRGRHGPTRRRRSPSYSRSPDTRGRKRRRWRSPDHDDIRARSSSVSRSDRSRSPRRRRRKSPTPSSRSPSRSISPRISRHRRDSPSISRSPSSSRHRSRSRSPSRVNGDKRARGGRGRRSPSPGAKDYRADSRADITKDHPKSHDARRRLSRSRSRSRSHSRTRERPSYRRRRSPSRSRSRSRSRSPFHDHDRDRDRDRSRSNSRSARRDRNDRKRHQSIERYAPAPRRRHKGASASPPPAPEKEQTVVANSQEDKETKGSHSPPPPIPCRAKSSEPEPELKGSQEKKEVEDKEKEDKKAASPEEVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZF3</accession>
    <name>A0A179TZF3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01266">
        <property type="protein sequence ID" value="OAT01266"/>
        <property type="gene ID" value="BDCG_04749"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04749"/>
    <dbReference type="OMA" id="SWPPFTS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="460" mass="50938" checksum="5EEAF3F0757D233E" modified="2016-09-07" version="1">MTQIAASKEDLSSWDSFQWRRRMERFGENDQALMAVGPEGEAEGICLPGELTDEGRESTYALGRRLRHLYVDQLGFMPKIRSNTDDMYLRTTPIPRALESLQQTFWGMYPPDARTANFPLPTIVARSPADETLYPNESNCHRFRQLARLFAQKAANKWNETEDMEYLNSLWSKWMPSNSPRVAVDSSPRLSGIMDTINSTLGHGPGTRLPAEFYDSKARELGEKIVTDEWFAGYNESNEYRKLGIGALMGDIVDRMVHASVDGGWRPTTNGTGNGNGIVKFALSGCHDTTIAAILTSLGTFDGGKWPPYTSSIAVELFKATAQPHGPRPGDILEELNVPDLENSASKAKQTGLMSKFFGGESSPAPSFPQPSKIARSATSDLPTSPLQKYYVRVRYNDQPMRIPGCAAKPSNHLPGNDTFCTLEAFKKIADKFTPRNWHQECGNNLGGGMYVEGNDPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZF6</accession>
    <name>A0A179TZF6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Benzoate 4-monooxygenase cytochrome P450, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_00636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99511">
        <property type="protein sequence ID" value="OAS99511"/>
        <property type="gene ID" value="BDCG_00636"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00636"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RINLHYA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
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        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="368" mass="41317" checksum="E9C95EA9BA73A40B" modified="2016-09-07" version="1">MAKHANAAPPLFSPKHAPELESIIQAKAGTLERRIRTRLRNVGKINLHYAFRAMSVDIVTQYASDGKGYGFLGREDFGKEYFVLARQVARFVWAFQQFPTLMGLLVRVVPVRGVRELTRLLEQNGTRKGCFNPTLLEVDAVGGQDNEEGRSAIGYSKADVYDALAVVSHMAGNPLTITAYNTVVNKEVYRMLKTELTTAFPDPKSEPTFAELEKLPFLTAVIKEGFRLSYGMLGRLPRVIPEPGAEFNGYRVPAGSLVSMSSWVMHRNEELFPEPDEFDPSRWLGTRASSKNLEQYLVMFSKGSGQCMGLPLAYCEMYIALARLFRHFNDLTIEPRGQEDPGYDDFFTPYHRPGKEIFCFAGSGCDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZF9</accession>
    <name>A0A179TZF9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00021">
        <property type="protein sequence ID" value="OAT00021"/>
        <property type="gene ID" value="BDCG_01792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01792"/>
    <dbReference type="OMA" id="IYPRSAR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="269" mass="30214" checksum="F52EFF85E11968DB" modified="2016-09-07" version="1">MPVATATPRKDRLWGHDKRSRRSSPSSSSGTSIIGYSETDSESYEDSMPLLRKPSPSRSKQRAPRISIDTSNLAERDKATSSSLSKGLISPIYKTIYPISAKDVNTCLSPVYKVIYPRTDDKDGNPQSPIYETIYPRHTRRHSLVLKSPIFETGYPREKEPSTPAPASPASPIYVTIRPRSKDCDYSNQDVAEHQATSPMVMFRDGQHKVTCTKGHTIWLPESENTASQRRRQKCCSCEIQEEIKTSCAKYQKPDIQRRCSTSSYGMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZH5</accession>
    <name>A0A179TZH5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MADS-box transcription factor, other eukaryote, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_02301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00257">
        <property type="protein sequence ID" value="OAT00257"/>
        <property type="gene ID" value="BDCG_02301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02301"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="MADS_SRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SSF55455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT00257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="219" mass="23643" checksum="ABE076E4863EEF23" modified="2016-09-07" version="1">MADITAVSDENPSPPQDDLVSGGNGAAAAAAAAVAAAVENRGTKRPRTSNAGDEDDDDEDKPGRERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKPEGKNLIQACLNAPEPTTNENGVEVPEVPPETSDDVSHANVAGQQPNIPRPGGMHPGYMSSEHQQQIAYYQNLQQQQQQAQAGGQYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U005</accession>
    <name>A0A179U005_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01465">
        <property type="protein sequence ID" value="OAT01465"/>
        <property type="gene ID" value="BDCG_05259"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01466">
        <property type="protein sequence ID" value="OAT01466"/>
        <property type="gene ID" value="BDCG_05259"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05259"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="326" mass="35502" checksum="DD27775D400C2A70" modified="2016-09-07" version="1">MDGDSHQRKTYGPSGYRTGSGIGQHPIRHLSGSSSDRFRHQQQPEPARGPDTHEVIPQDRTSSLSAYGAYVYTEPPSCNTPSLQGGTLQGGGLQYESNFSSTSPRNQQPDQQQQRLSQYDGDMVYGITPQVQPQAPYEGVSQYQPRQSAAIEVLATQFGVPQYFQPAGPAVAGVSDQYLTASQVQSTQYSQPASPTRASTTSALPEIMADLHASAATEGLEHADFPRESPSGFDDAYNQYQRALRQTFENTRSGRLLDASQSLLEISEWLLGNATELGTYHPHVAVCSPLSFTWHLGGALPFELIADFRSCSRRGRTAPGSNKTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U008</accession>
    <name>A0A179U008_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_17109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01494">
        <property type="protein sequence ID" value="OAT01494"/>
        <property type="gene ID" value="BDCG_17109"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_17109"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="389" mass="43238" checksum="66B8DD60A3D24018" modified="2016-09-07" version="1">MSSRSRSRKRRPGSSPSASTDTRGTTKSTSTTPYNCNFQQNLIDHGVYPDGYEYPDGRIPVMPNNWEEINETLARPRSSLSPSKFSDEHFQKFKRADTHASKEQPVTTSVIPIIEGDVDDPKCTGGGYLLGNLAPLTDGTLAQAKPDHFYGARPEQLNHRIRNELCNYIIPSTQDDLPMIPNFFLEAKGPDGSLAVATRQACYDGALGARGMHTLQSYQQDRSTYDNSAYTLTSTYHGGQLKLYTTHLTEPEGPGHRPEYIMTQLNTWGMTGNLETFRQGACAYRNARDWAKEKRDGFIRLANERCPDAKSQQHCASQRGTATDEAVTLDDSDVSTVFDEGAHQDVQWSFTTPVEDADEESLSRMPKKPRLNASVSFGGTVDRITSHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U023</accession>
    <name>A0A179U023_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dienelactone hydrolase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_02803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00437">
        <property type="protein sequence ID" value="OAT00437"/>
        <property type="gene ID" value="BDCG_02803"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02803"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="287" mass="32315" checksum="870A1D0FB0C2EE12" modified="2016-09-07" version="1">MPKLCAVVAYYPPRIPRPTGDFPSQLHLTIHLAGTQKFGGMNNCYTYLHAKPGFAELDNPEYDEISTRLAWSRTLACLLQGFEIHRDLEPVWERHIDMLYSRKDAMGAVQTMTEDSYVNFVPTMTGGFGSDELFRFYADYFIPGTPPSLNVRLISRTVGTNRIVDEMFVTFRHTHEIPWMLPGIPPTDKEVAIALVSIVTVRGNKLCHENVYWDQASVLVQLGLLDPKYVPAGFNGVARTNGNAKEGDDESGSDRNVDALPVVDAEGAWKVFDEESQQSNELIKDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0P6</accession>
    <name>A0A179U0P6_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01350">
        <property type="protein sequence ID" value="OAT01350"/>
        <property type="gene ID" value="BDCG_04982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04982"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="388"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="601" mass="67254" checksum="C38CF87027BA6565" modified="2016-09-07" version="1">MVVLSPSPTDGSDKVLLPQYKKKYTAGSPLARGTPATPSNRQQPALPVQNLHEISNQRSSTTTNCPDTSPTNIASGTGFLSARRAIQKIPTSHGPPKPPQLANMRRRKPKVILNAPNETSIGPLKKTEIDDKLERLQREGKQKIGQQLRGIDLHAAEGPSPLDRARQGEGNDPTSPVAKEISLALAKRDIAALSPSLHDSRSGKNSSGDTGLDNGDSSDKAAYRTPFSERNSDYSEQRNNHYSMSGGDNLSMSVVDWHHRPWDSHSGPKYTHRFKNWLKTVGELDRVWVDTNSLEFNDANYHSSGGRGTFHSPVKSPITYLDPADPQSAAHAHETASGYIHNWNSQLKRERQEAKWKKNQMAMQMQLSQQCRQPLAIEMNPHTPKLNLYLRPIETKDIPGLLKLFNSYIQNTVRCVDLEPLSLESLEERIAECEREKFPALVAVEQKPRLGHALSGEEEEIFGCILACDFTGPATIHRYTAELELFVDPKYCRLRVGSCLVDKLLEICDPDYYPNQGYHFDCAAAQADVYRAGKNRQVARLIFILHHVADNDGDYQWTKEWLVSKFGFEEQALLKGTGLKEGKLLNSSYLVRSIRFMPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0R3</accession>
    <name>A0A179U0R3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AGC/AKT protein kinase, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_03766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00868">
        <property type="protein sequence ID" value="OAT00868"/>
        <property type="gene ID" value="BDCG_03766"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03766"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYENQCI"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="108"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="824" mass="92101" checksum="667E43EF26822F4C" modified="2016-09-07" version="1">MEYEQFQISAESHYCYNGRIGWSNPRTGYRASDGRYMYKFDVSTTSSELAVRMFARRSDAEAGLQTVSLGSVMVNPFTENRPRDRHGYEPIPVQGGTGKVPIDISYLEKKVPPLGDTEVWCVYGEMGSSDLVYVEKLDTDRSYGMKTIPIVVDVTHESKLTHRVEHPFIAPLKFAFKSSKGLSLLSPLASGGPLSHHLQRVRRFDVGLARFYAAELLCVLEYLHDNHIILAHLNMEDVFLDSPGHLSLCNPSLFSLEVQDGDTVVPGTSAYPAPELVSNNQVASQTADWWALGIFLYEMLTGLPPFYGQDANKRRLKISRDPVRPEGLPPIAKDILIKLLEKNPLNRLGAKNGTSEIKDHPFFKGTNWHDLLQRKYTTPFKPHDAATDFWPGAKEYDSDRGRKVEEKIENGKVYQRVVGASWPRCEWNQTGWVRDGSTEDNPDRPSSPTREDYDDGWELLWDPTSYRFNFRNRFTDETSPGRLSDKYSRTYLWGIPQEPPAVPPAASNPACRPPPLSERKAALAAALVAGYGVRVFSQILRHGNDLSLDFPILCYNQPYRPKEGILNSVEYFHEIQLTPLEWAVEHDRLDLVNLSLAHGADANYTIESAEGPALVKAVRRGSLKLVEALVQKTNRVSGTRALLLAVKQQHSAIVNTLLANGVQCDFEESDRPLPDRRFFSDRDTTPDQPTPLQAERFAPPLLLAVTSGNADLVKALLAHGANPHAPYHGVRGLRRDHDGSGLKVAASFTCGRVIQLAMEYWQNSEIVQLLLDAGADISLHHPVWPVPVWPVGGHVCEPVPRAVYLEVTAGLEAAMAERKRQGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0R8</accession>
    <name>A0A179U0R8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_03416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00707">
        <property type="protein sequence ID" value="OAT00707"/>
        <property type="gene ID" value="BDCG_03416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03416"/>
    <dbReference type="OMA" id="DQHRATI"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="847"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1328" mass="148159" checksum="AF7E411EBC4D4F99" modified="2016-09-07" version="1">MTSNPLGPLGECRTMGEDLFSVNLPSDEAGLSPTSKKILEKCAIPVTPVSLNSCFQITPTLISRPPNSDLETGEFNFHFAKPKLPTPNFTSRLKAKPAGSILASASNQKVIVNPSGTNCPDSNCTESSSSGTSALSKDSAINSGQVSPTKSPITHDTAERTCGPTAGIHRSSKETGHSLEIGDRADSQSENDALEKDSNLATNHTQSAQSPNQDPTGPIPNTDNCNSPASARSHSGNPKLTPPRPSAMKATPQPKLMVNSKVTKHPMSAKSVVNGVATKQVTLQKGSSSAFQPSEEDLFYMLIRKLKKRDEMEAEATAMKERMKDEMLALTRTNDDLRSRLRESQISGKSQQERLNASNSLVERWKTKFSKLRTFVTSVGSDFESLRKEGQILKSTQESLLQEKNQIHETLKQMSDSTGSLKTRWSQHRATIVGVRQEFNTLEKSLLTATTRVTETEKLLSRERNHVATLENYIKNHSDRHHKQALDIDERQSQMIKKIDTIHKHIESWNSAQSSIKDELESGFTSCMSLLKSLSQQQTLKPQDLEKVDCAIRDLSMQLHVSIEASKKNMEVAFDLHTNYGQRVSSQLTGLETAVKSNTEVVCQLAEARELHGNLQEKLNAADKSLHMVSADRDRLKSQEASLQRRIRDLEIEISSLQKNKIEDAQFRDADMSSELQIQLEATSASLTEVSNELKEKQSEISDLELKLTDTIERLAAAESEIAGLTSERLKIRDEAQKTEHRVREELTRANLAAKDQHRAWFEQERHKLKREKILAEKSAQKVAEELNSVKISLEAAEKGNHELVAKMSQQQSEIDSLKMTASKRDSNIAAEMDEVNMLHASTIQELQSAQWQLEAATKEKEELRHQLSELRMNLATLQEQEPLQETVEVLQYEIAEKDINLLSLKEELSKSEENNKTISQLQQEVADKSAEIAILRERLDNQLTSVTTIGESLKEKNNELIILEQKMEAFGKLSAETSALKRDIEQRDNELAELRSRVQESNVIFKNTESILRQLGIIGTMESLRDYSNVLQSRLKMMAGSLDGRQPKEPIESGLHIPMRISSKRQRTSRKRSMSSTHAECARPGSSSRERQTTEIVYRTRSTREIISPTLKTPSRGKNANSGLPTTSTSFIRPFSRLQNETTPAIYPGEQMSPVLEFTDLNALFPTTPMNAKNVGSNQARMAAAQNSLPSDKVILPCEVARTKERSALCVSDAVNDAICTSRRDKECEQSRGSIEAEAPHEATGNEPAAAASTPNKCRIDNNLEVQDNPCSPPKTIARTLKRKKMSEDEMHTMSNSRVRRLQARNPRKSSLAQESLRIRQSQPHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U105</accession>
    <name>A0A179U105_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding protein MSSP-2, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01806">
        <property type="protein sequence ID" value="OAT01806"/>
        <property type="gene ID" value="BDCG_06080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06080"/>
    <dbReference type="OMA" id="SFESCEN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="290"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="378"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="627" mass="68827" checksum="CBBFB5D637480352" modified="2016-09-07" version="1">MDILEKLGILAAKPGLNGSSVTPFIQKSQFANMQAQTQQQQLPGEASAAHSQNQPAYNMEHQNRFYQHVPQTSGVNGSMRDPNVQAITHAVGGLNLQNQRHNGKFVAFKGNLHASHGSNGDMASIQRPYNGQYLIVPNGIPYLPAGLYPNFVTAPSVVPGSVPGYTWPYAMNGDAPELSGPRRDSWSSIEENHPCTPGVDQAGHQECYPAVAPTDRSPMLYNYGTPSPSMVPPQPYLPYQMMKGAGGYVLQDLDALTQQDPAIPRAVPAMWTNPSDLTLAKCLENREGITNVYIRGFLPETTDEMLHAYASRFGKIDRCKAIVDLETGLCKGFGFVQFFSFDACENCIRGFFHLGYQASFAQKSRNSRLKDLEDKSSTNVYCTNVPIDWVEADLRRHFQPYQVVSEKISRDEKTGVSKEVGFARFESREIAEKVLSQFHNITAQDGVKLLLRFADTKAQKQLKLQSNERRAYRAGEYNYSVEMVNGSTPSPTLQRLQQTASHFSPNSQASFPSPLGPGPVWTPATSISPPGPMMNKSVNSLRLNSWGPRSNGNIENTPTFRGRPAFNSQGSYGDSLSTGSSKTVLPVSGGVTRSENSSPRKENYRAGSTSPLGRRREITVATPKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U122</accession>
    <name>A0A179U122_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_06077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01805">
        <property type="protein sequence ID" value="OAT01805"/>
        <property type="gene ID" value="BDCG_06077"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06077"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="PTHR12295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOR2-PAG1_N" evidence="2">
        <location>
            <begin position="192"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="MOR2-PAG1_mid" evidence="4">
        <location>
            <begin position="806"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="MOR2-PAG1_mid" evidence="4">
        <location>
            <begin position="1292"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="MOR2-PAG1_mid" evidence="4">
        <location>
            <begin position="1620"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="domain" description="MOR2-PAG1_C" evidence="3">
        <location>
            <begin position="1808"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2233"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2257"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2309"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2315"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2352"/>
            <end position="2367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="2419" mass="270159" checksum="8A21C4F6E3ADBA36" modified="2016-09-07" version="1">MQPLSLATIPDNHQAEMASEPSSQRKATTSGKSRRDHSHHPSHSAKHSQEARTVGEYALHHLFNSFVGQADEKINQCILSIDEYDTPVEHICGPGADPIFDQLISALGHIAKRKPKPLIDTIMVWRKAKGEAASAAKHAASQARQVPPFVGALSRRNTEPTHPGPESQDSSAVPNGSHLSPVSRQEDVILAERRATVSVYLVCRVLIEIFNQSTLQAITSEMAERLEDIVFGQLKTVDPDQIAASPLRMANWRIYGQLLGIMSESSFTSVTNRFLAELSQFQKDDFRLAAAKDAEAKAELLIYGMRHIQIRTSPEDVWSRSCDFLQSVARLFVNSHGQALKQAYCQILEVLLLPIAGNLTCDFTSPKWKELVDILFPRLSQILGKPRHWNSAFPLYTLLLCVSPKETFYAQWMSVITSLPPKLKDRPTRGTALQAICRLLWTYLFRYTDSQNNPLRKIDEITRIALPGGRRTYLTTETAVAEPLTQLIRMVGYKHPDMCFRGIIFPLVNSDLIMSGKELKIEQMEPEKMVIGIRSFLAIMADLDHGGQQPPPFPQDFAVTDQPFTSAFPFVDPRTTTVDTLNPNKKALQEAVFRPVNTAKLSENSRKFYFRFCEILGKITILCDNTFGGQAALDEKFGGVTPKTPIAEAFSFGRRDDHSTGPDQKQAFYDLLHVAVQALPRCLCDHIPFNSLINLLCTGTAHVQSNIASSSAESLKSIARQSHAQHVAIGFARFIFNFDARYSTMSDEGMLGPGHIESTLKLYVELIQIWIEEIKQKSKDASSDPAENGGSGSRGVQLDLSAVMAHVEEIESHGLFFLCSQSRRVRAFAITVLRLVTEFDSALGKTGKDVPRIIQILEDESYNVLDLKDDLLTVAERSRLQKGKQQNGPHNTLIEICSSEVSYDSTLWSKVFPNLIRISFRTCPFAVTLGREIVCARLVQMHNSIAALAENFQPGQYASLDIVQGRPAPRSSNSPDILVEQWKLYLIMACTTINTAGAQSQSQLANAQHARKTSRAGQHPQDKIGSARALFATVIPLLSAGPDSIRNAIVVALGSINKNLYRTLLESLQYAVTTCNEEARVRIGTHNRTPSSPRRNRRTDRLRTEVTNVYKVTSHFLKEPEVYNDDWILNNLVTYTKDLRIFLSDVEVQNDLEFQRLRFHYCGLLKELFEGINKSKDPSRWMPFESRKSAFSLMEDWCGYSPNQSQIAAREENMRKLALARQREPWEVRSTAALEIEKRNLRTAALSAMASLCGGPIKITTESRATLQFDVRRMLSWIDIILNTVSDKLHAIGRRALKNLIVHNKDLPHLLEQSIEMCYISESPKALESYFDVVAQVLIEHTDYPFAFWRILGAVLFALGNAKREIRMKSARLLRTLEERQQKNSRIQDFDISISDKTTAVYKLAQFETSKRLAQQHTDLAFTIFSEFSLHFKKIQPDTQRNMVAAILPWIQAIELQVDPNGGPTAKSYMLLANLFEITIQSGNVLPNEVQALWQALATGPHAGNVQLVLDFIINLCLERKEQNFVDYAKQIIVFLSTTLAGSKVIEFFLMQVVPKNMVHERRDPIPLPPDLKSLPYVADLGTVLPVGNKQAGFSLGQVSLIFLVDLMVSPVTLGLDSVIKLLHTALIFWDHYTLTVQEQAREMLVHLIHELVASKIGDSPDGMRTSIEDFVECIRRGDAAVVWDYEDNNGGDDDQDTSRVPASMHRVTQDVANFFSAAYEGVNDLWAKEALNWSTSCPVRHLACRSFQVFRCISTSLDSRMLADMLARLSNTIADEETDYQTFSMEILTTLKVIISSLAPQDLLRYPQLFWTTCACLNTIHEREFMESVGMLEKYLDKVDMRDPAVLTKLRESKPAKWEGDFEGIQVLIYKGLKSGELLDKTLSVLHRLTALPNDELVGDNNRLLFAILANLPGLLHRFDLPERPKEVVERARLLASISENNGYTRLSDCLFGFSSGHYKRSQDLLVDTVEAIRSYYFPAQEVQTLIFLMGLLTNTTPWFRIKTMKILCALISEIDMRRPEIACYGPDLISPLLRLLHTDLCPQALEVMDHIMTVSGNPMERHHLRMSMASSCSSRAIRKEFERIQSLYGIPERTGWSIPVPAAQSALTRNNVHAVFYTCADADGSEQTPASPEMEFHVDEYNNLYFPGLRADTMKSFDTQNDGSMGDLLQKLDSLDDFFDETEAIPAPLNSISGTTLHSFASDFHDASANLYDQQTAPLLRKSLARTASSSSFHNGLAESRPTTSRTDVTGMHASTFSVNSGIPSSRTSMHTRSVTSPANTYPSSSQLSIPMFGSSTTLPFLSDDELEEALSDSDQPSSNSATSPRHGSEGPFSLESVIRSSVRRLTGGTSSTREKERQRDLLRAQQRAFVHTASSPRVPKVPAEYLTGPAGGLPGGSTSGPTTSAVPPSGPASPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U124</accession>
    <name>A0A179U124_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00827">
        <property type="protein sequence ID" value="OAT00827"/>
        <property type="gene ID" value="BDCG_03668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03668"/>
    <dbReference type="OMA" id="RRSYVQK"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107155" evidence="1">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="123" mass="13199" checksum="BE42397212B73CC1" modified="2016-09-07" version="1">MQLQNILPIAALLVTIVAGAPSSPDKRSDADAATMYVVDKRSDADAATMYVVDKRSDADAATMYVVDKRSDADAATMYVVDKRSDADAATMYVVDKRSDADAATMYVVDKRSDADAATMYVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U132</accession>
    <name>A0A179U132_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_04056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT00999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00999">
        <property type="protein sequence ID" value="OAT00999"/>
        <property type="gene ID" value="BDCG_04056"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04056"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="206" mass="22848" checksum="E1CB5E5AFD0C63EB" modified="2016-09-07" version="1">MPLDMVSNRSPIILSLDSTGDLVEHLLARDAPATTLIPPSPQDDHGMDYHISSNCRFYNTIGLIAQSKKVTLAFCPSLEHFRAYISVFRRRRLPSPQQEHGRLSYRSRPVLAVLGLIALHYDTKEFSAQGIAKNLALTVEIAAREGFNLTLCECVVVGRENASGGRLWDAEVPLLSGQTLVAGTESAHTGRTVKVNQVARRWFYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U137</accession>
    <name>A0A179U137_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01470">
        <property type="protein sequence ID" value="OAT01470"/>
        <property type="gene ID" value="BDCG_05264"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05264"/>
    <dbReference type="eggNOG" id="ENOG502RZBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="APLHQTF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="605" mass="64861" checksum="32368699A35BFE57" modified="2016-09-07" version="1">MSTAVAPPTAAPLPPMVDHNRDHNRDRDRDRDRDRDRPSAFGGRDNDSFSSSSHPVLAPMSSSSSQPATTSTPSRPTTDRASGKITPPDGKRSPNTGGAGSSKISVKKEPPTSPSLHSSSRHRPRKLDLSASTLSAQSGSSTSRGPLTAREGGLTAMHDVGLACLSPGFQTQDPAIREQLQRSISVRDQQRSIIESRLQKTAKGDGPDGIKPSESNLFGSLKTPSSKKRPPPGLSIVPPSASQFANERVIQSAPLNQTFTGRHHPHPISRHLMNHPSDLHMNSPIHHATPANQTNNRLPPIADVFGSDALVPRNQDRDHRDWDRDDRNNNSHSRNSNTNNNNNGGFYQSTASSFNNNSTSNSNANSNNNSNNLGPLPSPSLALNNPTSSSTSSTTTTKRAREYRSAEEAVHELAGGREELLPRIIHYNGSTNSTTTNNTNQRHHPTSPPPPGASINGTQHTSNSLHYHHHHHHNQQQQPQQQQQPYPPSTSGRRRTRNEYERDNGSPPLGTGPPDMRFRGAPATAASTTSHGPTAAHGGSPGGGHHHHSHGAGAAGGASYSTGTSGAFGFGGGAFGAVRDSPETQRRKKEEFLGLCARAWDLFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U144</accession>
    <name>A0A179U144_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Sugar transporter, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_03709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ER-3</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00846">
        <property type="protein sequence ID" value="OAT00846"/>
        <property type="gene ID" value="BDCG_03709"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00847">
        <property type="protein sequence ID" value="OAT00847"/>
        <property type="gene ID" value="BDCG_03709"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03709"/>
    <dbReference type="OMA" id="NDMPREN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT00846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT00847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="431" mass="48732" checksum="B9A07CC4F93F4CCA" modified="2016-09-07" version="1">MSIGALLQCTAYDLPHFIVGRIVTGIGNGINTSTVPTWQSETAKSHDRGKLIMIEGALITGGITFSYWVNYGFAWIGEHEVAWRFPLAFQITFAMIIFCSILNLPESPRWLVMKNRNEDALDILEALNQKPRDDPAIKAEFEAIEATVQEMSKGSYRSLFQMSEYREFHRVALAYVIQMYQQISGINLITYYAPQLYSQIGLVGSNLPKLLAACNGTEYFMASFIPIYIIEKVGRRPLMLFGAAGMSISMAVLAGANYRLTHLDDSRAGITQAVFLFVFNTFFAIGWLGMTWLYPAEIVPLRIRAPTNALATSANWIFNFMVVMITPVAFDSIGYKTYVIFAVINAFIFPTVYFFFPETHYRSLEEMDSIFKKSTNVFNAVTNSVKEPYRYDKHGQLKPEYLEEAVRRKSTIGHTLPSVEHDGDTTPELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U145</accession>
    <name>A0A179U145_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_01895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">ER-3</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00102">
        <property type="protein sequence ID" value="OAT00102"/>
        <property type="gene ID" value="BDCG_01895"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00103">
        <property type="protein sequence ID" value="OAT00103"/>
        <property type="gene ID" value="BDCG_01895"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01895"/>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PTHR45843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="159"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT00102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="351" mass="40318" checksum="DA6EA0C11F5C3503" modified="2016-09-07" version="1">MKHTERGTVSMATVPSTKDPDERLAGSQFIITLGDNLDYLDGKAVIFGKVVEGFDVLEKINDAFIDDKGRPLKDIRIRHTVILDDPFDDPPDLVVPPESPLPSKAQLATVMIADDEELDENIDEEAVEKLRREREARAQALTLEMVGDLPFAEVKPPENVLFVCKLNPVTQDEDLHLIFSRFGPILSCEVIRDKRTGDSLQYAFIEFENQKDCEQAYFKMQGVLIDDHRIHVDFSQSVSKLSDSWRNATNSKRASQRGGFGGISSLEKRRQYRASEAPRRDGYGMIFHKDDMRRKGDTESYRRSRSRSPSRRHRHRSRSPPRRRSGDDNDALYRRSKDSSRHTYESGRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1R0</accession>
    <name>A0A179U1R0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_02407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00312">
        <property type="protein sequence ID" value="OAT00312"/>
        <property type="gene ID" value="BDCG_02407"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02407"/>
    <dbReference type="OMA" id="HAGEMED"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="423" mass="47481" checksum="C54103823A053A00" modified="2016-09-07" version="1">MSMLNSDEPPPPPYSFVGSSQLSPAPSVPHAPPPYHHLLSSGQGGLSQAQQPQSFSNSTQLGTVDNRRPSRRPERIPSHSQNAGQNENAYWAPRQRQEEVRLRQGDLVILMMGHTGSLKSSFISLFADGQSAPIGHSLTGYNIEIYPYQIDQKTRVILVDTPGFNKANRSDTTTLSSIANFLCLLYSNNIKLAGIIYLHDITSRRMDGPALRNLRMMKKLCGAGNLSHAIMTTNMWGKLHTFDEGVALEKQLRDRYWSSILSHGGMMMRHDGSKRSAQEIIKACLLRSQKPIQPLDIQREMVIQGQRLGDTMVGRELYAEIREERQRYAGELAALCEELDEALRRKDFDHGRVLGETMEQLHRKLRLVEKSGKMLRRNFQRLADEVRAREDGQKRGQKKSFGRTALGIGVGTIVGLTTGFFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1S0</accession>
    <name>A0A179U1S0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01077">
        <property type="protein sequence ID" value="OAT01077"/>
        <property type="gene ID" value="BDCG_04220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04220"/>
    <dbReference type="OMA" id="IENGPTR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="214" mass="22941" checksum="D0008C1DC48C54EC" modified="2016-09-07" version="1">MIPKSSMNLHLFSSILTVNTQATSQIEITTVTETQHEMTTLSSTQTPTSTSTSGTSSSQSADSIASVTPTEPPGQNDEATSSSSLSGGAIAGIVVGTLLGIGVIVSAILWLFYIRRRREREDSKVGMNGYDHPASSPSFHTSIQSPAMTYQRSPSMNGPMGMHDRNLLGVSGFTDSRMKKDAAIYPNGNRQSNVSLQDNQDYSRPVLRLTNPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1S3</accession>
    <name>A0A179U1S3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor rse1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02065">
        <property type="protein sequence ID" value="OAT02065"/>
        <property type="gene ID" value="BDCG_06665"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06665"/>
    <dbReference type="OMA" id="FFLVQTE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="Cleavage/polyA-sp_fac_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Cleavage/polyA-sp_fac_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="MMS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS1_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="CPSF_A" evidence="2">
        <location>
            <begin position="615"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="970" mass="107727" checksum="FC47F0FE63031C93" modified="2016-09-07" version="1">MLFQVPGGADGPSGCLVCAEDNITYRHSNQDAFRVPIPRRSGPTENPERKRYITAGVMHKMRGAFFFLLQTEDGDLFKVTIDMVEDDNGQITGEVRRLKLKYFDTVPIASSLCILKSGFLFVASETGNHHFYQFEKLGDDDDEIEFTSDSYSADPSEPLAPAYFRPRPYENVNLVESINSLNPLMDCKVANLTDDDAPQIYTICGTGARSSFRTLKHGLEVSEIVESELPSVPSAVWTTKLTREDEFDAYIILSFSNGTLVLSIGETVEEVTDTGFLSSAPTLAVQQLGEDSLIQVHPKGIRHIHADRRVNEWPAPQHRSIVAATTNERQVAVALSSGEIVYFEMDTDGSLAEYDEKREMSGTVTCLSLGEVPKGRARSSFLAVGCDDSTVRILSLDPDSTLENKSVQALTSAPSALSIMAMSDSTSGGSTLYLHIGLYSGIYLRTVLDEVTGELSDTRTRFLGLKPVKLFQVSVKEQKAILALSSRPWLGYSDLQTKAFMLTPLDYVGLEWGWNFSSEQCIEGMVGIQGQNLRIFSLEKLENNLLQETIPLQYTPRHFIKHPEHPLFYVIEADNNILSPGTRTKLLNDSGAVNGDAMVLPPEEFGYPRGTGHWASCIQIVDPVNSQSVISQIELEENEAAVSVAAVTFSSQDDETFLVVGTGKDMVVNPRSSSAGFIYVYRFQEEGKELEFIHKTKVEQPPMALLGFQGRLLAGIGTDVRIYDLGMRQMLRKCQASVVPHLVVGLQTQGSRIIVSDVQESVTYVVYKYQENRLIPFVDDVISRWTTCTTMVDYETVAGGDKFGNLWLLRCPEKASEEADEDGSGAHLIHERQYLQGAPNRLNLVAHFYPQDLPTSIQKAQLVTGGRDVLVWTGLQGTVAMLIPFVSREEVDFFQSLEMQLSSQNPPLAGRDHLIYRSYYAPAKGTIDGDLCETYLLLPNDKKQQIAGELDRSVREIERKIADMRTKVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1T1</accession>
    <name>A0A179U1T1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose,sterol transferase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01278">
        <property type="protein sequence ID" value="OAT01278"/>
        <property type="gene ID" value="BDCG_04781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04781"/>
    <dbReference type="OMA" id="WRSCIET"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="891"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="930" mass="101113" checksum="B996F778356396C7" modified="2016-09-07" version="1">MPWSPTQAFHHPLANVQFSDAEVGIANFVTYALVEMLTWQGLGDVINRFRERSLGLDPMSMMWAPGILPRLRISFTYCWSPALIPKPKDWGPHIDIAGFFFLPLASNYTPPDDLAAFLAAGPPPVYIGFGSIVLDDPNAMTELIFDAIRKTGQRALVSKGWGGFGAEEFEIPEGVFMIGNCPHDWLFKRVSCVVHHGGAGTTAAGIALGKPTVVIPFFGDQPFWGSMVAKAGAGPKPIHHKELTADNLAAAITAALEPGAKRKAEELGAKISHEQGVQAGGKSFHKELDIDSLRCMVLRNKPAVWLVKNSNIRLSSLAVTTLANEGILDLGDLKIYRPREYHTEPGPRDPITGGAGALIETLGDFTMGVADIPTDILFALTSSACRRHAKRKSKSASHSRKGSQVSADTATPSLTSTTTPSEIGTASEHCIPIVSVEDNSDGITERTSASSPERDGSVPRIHKRKSSEIRNIRAADIVLAGQTAKRMINMGLKSPMGFSLGVAKGFHNAPKLYGDTTVRESPKVTGFHSGLKAAGKELGYGFYDGISGLVTQPLAGAKDGVGGMVKGFGKGIGGLILKPGAGIFALTGYTMSGVYKEIQKRLGTSVDNYIIASRSIEGYEEWKQAPKGVRDAIVRGWYSLRANPDVKIRGSTFASELEALSRGVFDHIYTSSEAKRRISRSSSPARTGSPPPERLFHTFRTARERTSSCPPRQCHHDNHHHHHDPRRNTMCPSVASGIEEAIHKSVEQSSCTDAEEARLIERALRASVLELQAAEADGESEEHAYTRAIKASIEEAQRAQRENCHHTQPHPHTRPDILLDGQHLTTSPPSSPTPNIYADQADQDGDEVGDENDDLERTLAESIRSYAEEQLRDEEEMEALTEYMLWKSARNCSGSDQVQQTQPEKQTSTEDLRKALEESLKTNETDAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1T2</accession>
    <name>A0A179U1T2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02054">
        <property type="protein sequence ID" value="OAT02054"/>
        <property type="gene ID" value="BDCG_06644"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06644"/>
    <dbReference type="OMA" id="PITSEWD"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="541"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="728" mass="82347" checksum="9845F63E548A3E42" modified="2016-09-07" version="1">MNSRVQQLLAELEEERALREEERALREIAEAQAEKERGLRQEEQRRREEEQRRREEAESLTADTQPTTFLPFLHNCHKLLLAIRIVTDPTRTTQVWRILNDHPLFLMKKQFPSKHQLEYVCKVLSPITAESDLRYYERETVENQVRNIVDQITEDISLKEAFGLRGSITFDSHTNVGCPQESLLSGEGKDLSINSETAPSAKAKSRGQKKKEPTAVTRGQADRFCIYHQDGDDHIPAIAIEYKAPHKLTQAEMTTGLREEIRPAWDVINQESEDVIFCCRRLVAAVITQLFSYMVQKRVRYGYVCTGEAFIFVYISDDPSSVQCALCIPGRDVKGTDDDDLQGTAVAQVLAFTIRALTSPPVSQQWSDAADELDVWPVEYSDILDQTPPAARLKHASPLYHGRRSHNLSPFRMTLRSGCRPSENKRRATSSPSPSPPPSPSLTPHSGPRGRARRGGHIQSAKPRETPGHGEGTQRMPNAIETLTIKTRPYCSQRCLLALRDNTPLDPTCSNYEVHRKHRIKAGEFRALVQKQLATDRGPDADCCPLYKAGSCGTLLKVRLSSHGYTLVAKAVESKNKDKLQHERKVYNQLRDLQGECIPVCLGVVKLEPKRPYYHEEKIHTHILLLSWAGESIEKAGTLSPANKRSTVCRALQAIHSRGILHGDAEPRNILWDQACERVRVVDFELATIQQPLSDASTNIVRKRKVMSTCFSKELQHIETVFEIQDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1U0</accession>
    <name>A0A179U1U0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_05867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01710">
        <property type="protein sequence ID" value="OAT01710"/>
        <property type="gene ID" value="BDCG_05867"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05867"/>
    <dbReference type="OMA" id="HGEPKMR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="573" mass="60972" checksum="C1D4FFE3A2254C91" modified="2016-09-07" version="1">MPVSHLTLTVSHLPTSTSFFLSCLQPLGYRFIGRHDNNVGFGSVPGEPADFWIAEERPGVPAGAAHVAFPAPSRDAVSQFFIAALKAGAKIHGEPTLRDAEQNYYSAAVIDFDGNSIEAVHRPRSSGSDKASADRALTIIKNGSVVSRASSTKTESVVRAKSEIGTYVSKAKTAVSKPAAASASPQSRAPASIQLQQQPVPQPRDSTNGAKAVVGTLLGAAAGAAIAYSIFKADSSEPSPTQQHQAIEAPPARSMTFGGVDNEYADYARTMLSKNPRASTIMEGLENCSRIWGQTQSVRGGDGYEYNNAGRRASSASVYSGMQDMDIPIRAIEAVPFEEEGSECSYSYARKQPSTFISSFKERPHHYDDDNASNYTSSTLKASSKTHHSSHSAHSRPSSHHSHSSRSTRSIITIKDIHTSSKSSTPTASVYSHTHSARNIPLPSGSVTTISTTSSSRRSSSKDHPSSRGSSSPSKHSSTSPTRSHHSSSKHSHASYANSSRHMPLPDSVAGASTIFLEGVDVDSHVTPVAASRASTSRRSTRSSKFDEPVRPSDSVSQVSTNVSRQSGRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1U1</accession>
    <name>A0A179U1U1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00342">
        <property type="protein sequence ID" value="OAT00342"/>
        <property type="gene ID" value="BDCG_02487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02487"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="135" mass="15198" checksum="02010279B0915E7D" modified="2016-09-07" version="1">MLLKRLEPTTRPNCKSAEGLGGNSAGQDEGPLCENGSGVMLYQEFYDTLRQFYCPLLLPTVDFGYLRLLIFSGDVWLSERMETLELAKKHFRYITVGTLDGQGGRFYRERPLKARFKLGELSPSSGDKARISTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U224</accession>
    <name>A0A179U224_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Origin recognition complex subunit 3, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_04011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT00981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00981">
        <property type="protein sequence ID" value="OAT00981"/>
        <property type="gene ID" value="BDCG_04011"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04011"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="PTHR12748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="ORC_WH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC3_N" evidence="6">
        <location>
            <begin position="176"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ORC_WH_C" evidence="7">
        <location>
            <begin position="557"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="ORC_WH_C" evidence="7">
        <location>
            <begin position="618"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT00981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="665" mass="74552" checksum="DC770440781735FE" modified="2016-09-07" version="1">MSVHQRGVKCPAPWHMRNKMICYLHLYWKATRTWNPSSCDIAYSKNSGRPRSSKFRKGILRDVDSEILDHVSTFVEQTSHDNGNGRIPAGLITLGSNFSSIGRLLDRLHRQMQSTAIGQVVALDSGDASNLKTVLKYIIRSGTSVVRDVDGDQDLPTDRAGPKPLAYDLDILHDHVKQKGIRKVVIVFRDSEAFDHGLLADLISLFSSWVDRIPFVLLFGIATSVELFEARLPRSLVNLLQGCRFDIQDSGDSVNRIYTTLQMCQEGTLWLGHNVSRILFERSKDHFQSPEGFANGIKYVYMAHFFANPLCTLLSKIESANILQSDLCQAIRNLPSFRRHVYGLLDEGEAGKARTLLEDDELLARYARANIRSGQEKINAMLHSVETLSTVLRILKIPRTPTLSELTIQALAGELLGSKIVEDMLAGLKKLPSNTIETILGALPQGMVEFDASRDVQGTLQSLLQNKKGSGPLRSEYDEYHSTHKTTVVGQRVKLTKSKAKLSKQDIEYTAFVNDLSAAFQDYFSINLISPLDLFMHEAFLYDLKTPIKGAFTPRPRSTIERALSTPFDYLATSALSADDEEMMPSKPAISILYNLYSETGSLVNVYDLWRAYYTMAGGDDGEEPDERQTLAVFYRALSELKMMGMVKHSKKKIDHLAKSTWMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U226</accession>
    <name>A0A179U226_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDCG_06828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02124">
        <property type="protein sequence ID" value="OAT02124"/>
        <property type="gene ID" value="BDCG_06828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06828"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAT02124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="933" mass="103169" checksum="D3E205B61E90C905" modified="2016-09-07" version="1">MDAATPISLFDEVAALKIVKPSLQLYVSIGGWTFSDNNTITQPIFGNIARSPANRRKFADNILSFLNQYGFDGVDIDWEYPGAPDRGGKEEDTENFVLLMKKIRETFDKSGRKLGITFTGPSSYWYMRWFDLPGLLKYSDWMNLMSYDLHGVWDRDNPIGSIVQGHTNLTEIKTAVELLWRVKVPPSKIVIGFGFYGRAFTLQNPSCGEPGCPFSAGAKPGVCTGQSGYLSQYEIRDILNKNSNSKRSTTSVTHDKEAAVKYFSWDSNQWISYDDEDTFKQKVDWADEVGFSGSLIWASDLVDDYDLTAHKALTGNSKLVTARSFRRDQAQKPLVDDLNDFLGRRCFKFKDTVDLENPQVASCSPYVKMGYDKAGCKGKDGECGKPICCPMNSGLKDCQWRGSGGDCNGRCHAGEVHIASSSWGGTPGQSGTGRCSRGGKALCCKMGMFDDFNENCYWSSGVGSSCKEDEESLAYMWDRTGWGTVFKHGNHFCCPKSQPMPYKNCHWVGEGDCADNTCNENEVTLEADSRGDSYIGCSWYREKSLCCTPNLDVLKTLKCDVDTCTDNEACDDESGLPDSSDVLYKRSYQDGQGRTLWSYGESGLPELILVPPRPGSPRTMFLDIPKLLGTNVYGALKMVSRPYKPGLSVASGDGASTLPLRGGFRMLKDVCGSTAVQYVKLSDLPMKGFHAEHLQEIQMVKRFLQTAVTGYLPSGAKMKSVTIDPQKLLDGWNKLYDVTLPRIGAIVSDKPDWTPPLTPNDRVFEIIGSYAYRTGMSILPRDMNYIKKNLVGGAQPMAISTFNTALRDVAKGDMEAAKLVAGKLQKTIGIFNYLNDGVLRGGLDKARRDLAKEIAIIGQFMPGLEPLSSIWKEFETDLYAEMVAVGTAFVLDSVGRINSKFYDKNTMSNPAAVALIAQANLLKKAIDKIRFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U227</accession>
    <name>A0A179U227_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00422">
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        <property type="gene ID" value="BDCG_02772"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02772"/>
    <dbReference type="eggNOG" id="ENOG502SS66">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="321" mass="35455" checksum="217B748963657DB1" modified="2016-09-07" version="1">MVLSNTCMHSTASPISFLLFDRQSANFFFNYSMSSQRRQQSRSSSSQRSRSSRKDQPATITAAQFEALNISSPTPPPPIAVHRAPEYAPSDLSALDANLAVVVSQAQQNWPSFQMTATVDSSSTPQSFTGVPNSEIRYSGFSSRQEQYTTEHMNSRFSLYKSSTFHYNMPSHSSAFAQPSYHYAGPGHTHLPAYGIEPESASSLEFPTNFTHRNPPPQASIPSDGLINMPPPGGYHYSVPQSQVSSTRQYKDRISITLSEHHAPDQESRPSNSRDEYIQHGFTSHPATEPYSDLSTNMASLTPDYLNHPVPNVTGHAYPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U235</accession>
    <name>A0A179U235_AJEDR</name>
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        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">BDCG_06849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
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                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
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                <person name="McEwen J.G."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
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        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02134">
        <property type="protein sequence ID" value="OAT02134"/>
        <property type="gene ID" value="BDCG_06849"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06849"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT02134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="283" mass="30350" checksum="F17A4892DFB224E6" modified="2016-09-07" version="1">MPDPVAGAGKMISATKRHSDENPYERSLSTSSDSLSSSRSGHHSTRQVASTSTPAPSEDTPIATSNGRGTERNYRSTEYAGGDYSQQPAQTPQPQRKASMHGRDNGPDEQGSSNAREGGAGAISRQYKRIVEKYGSVELENKGSVARDHLALERTFLAWLRTSLAFASIGIAVTQLFRLNSTISESNAHLLFDPSQAQVQQQPPPPFSTNNPLYSEHQYILPPPLSPPTLSPTTTSQQQNNPHNPHLKQPPTISSYTSKAANACAASASRSAPPSSALPSWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U250</accession>
    <name>A0A179U250_AJEDR</name>
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        <submittedName>
            <fullName evidence="10">AAT family amino acid transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_06997</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02195">
        <property type="protein sequence ID" value="OAT02195"/>
        <property type="gene ID" value="BDCG_06997"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06997"/>
    <dbReference type="OMA" id="VIMYLTP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="7"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT02195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="500" mass="54503" checksum="3A6C2A4B10E7DE8C" modified="2016-09-07" version="1">MSRIIPGTGLFVGSGKALADGGAASVLIAFILVGVMLYSTVHALGEMAVLFPVAGSFSAFSTRFIDPAWGFAMGWNYGLQWTIVLPLEIVAAAITVSYWNAPVSPAVWVTIFYLLIVSINLFGVRGYGEAEFVFSLIKVIAIIGFIILGVILNVGGGPNGEYIGGRYWRNPGAFHNGFKGLCSVFVTAAFAFAGTEMVGLAAAETANPRRTIPTAVKQVFWRITLFYVVSLAIVGLLVPYDDVRLVTGESSYDANASPFVIAIRNAGIQGLDSVMNVVIMIAVLSVGNSSIYGSSRTLAALAEQGQAPHVLTYIDRRGRPLVAIGISSVVGLLGYLAVAEKEQGAIFSWMLAISALSSIFTWASVCFAHIRFRRGWKLQGRSLDDLPYRSQAGVVGSWIGLILNCLVLTAQLWVAIAPVGFAEMTVKERVANVFELYVAVPIIISFYFPYKFWYRTKIIHARDMDLDTGRRDLDISHLIAEERAERAQWPMWKKVYKTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U258</accession>
    <name>A0A179U258_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02205">
        <property type="protein sequence ID" value="OAT02205"/>
        <property type="gene ID" value="BDCG_07032"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07032"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="123" mass="13558" checksum="02BEB5F433F715C9" modified="2016-09-07" version="1">MPGLHIPGIPTRPNDKAARKRNGPAFTTFPHRVAYKDPFLPAMDLTMAVPVLAPPVDETLSRLNQSSSEASRSTKSIHGLSRVYIPSETPRQSSANWLAGLSLPWRNRRTTKTVSIRLTGVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2T1</accession>
    <name>A0A179U2T1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_05624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01598">
        <property type="protein sequence ID" value="OAT01598"/>
        <property type="gene ID" value="BDCG_05624"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05624"/>
    <dbReference type="eggNOG" id="ENOG502S4WA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="490" mass="54850" checksum="0A4D8DE39B6E95CE" modified="2016-09-07" version="1">MDSAPREIPGYYYDAEKKKYFKVQANHAAPSGSKYTRDDIKKRKETSLKRKRIEEHSQRISTETIKRSNLLQCPLGGKLLQREYGTLPSSRSFVSEHRAVACARLLSRNRLVDVTSYDARFPVSRFARDPWSGNLLVAINTASNYNLLYSLIFLRNKVGPGSTDCIRGSVTVQWWDMTGVSSSNPSGESVHISTSRLTNQLDGRSATQYVVDTTTTFCYPGTMVWCSAPCPSATESIFVVGKSSNLLFITGIDSHWNTQTVRMPNTADIMAVEWLTPRVVMAGMTNSLVQFYDLRSQDTATRLQHPHGVYKIRKVDEWRIVVAGAKKNLHMYDLRYGPSGITTRPQPNKPSHISTEPYLTFHGYENDHLSHDELDISPETGLLACSSPSNKIQLFSLNTGKLIMPPPLIPSLPSSFPSAHIQPQARQRRAAEVSNPNRRDVPITHYLYPDKITCLRFENLTEVPTANGAGNTGKPSLLVSAGPIVEEWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2T8</accession>
    <name>A0A179U2T8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02110">
        <property type="protein sequence ID" value="OAT02110"/>
        <property type="gene ID" value="BDCG_06799"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06799"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="3">
        <location>
            <begin position="199"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="698" mass="76859" checksum="B1B267CFEB35A9CF" modified="2016-09-07" version="1">MTPSPPRLRILSVGGNAISAFLSWRLQATNACDVTLVWKSGFESASQYGLTFRSKVFGNERFKPFRVVRTPEEAGSTDQPFDYVILCVKALPDVYDLASVIESVVTPQHTCILVNTTNTLGVEAHLEHRFPTNVVLSLVSGIEIIQTGPSEFEITSSTNTWVGPSSKNAMIPSSIQNDMAVALAITLSTGQVDCKVSENIRQEQYERMIGPIAFHPASVIFERPNHADLLEKIGLRQLISDVIEELVSLAKTQGCTFSEKFKESIIEKMIAHSDAPSTMYQDFLARRPMEVETYLGSPVRIATETGIKIPRIETLYAMLHHLNASNQARQPQEPTSPGPVHPPPRLSSAPPPRPPMNGMRGSRMGPGPGMGMPPPRRGPSSMGMHPRPPPNGFPPRGPPPPMQRELSEEHNLDEFSHLMLYDDVLEDGAQNGGYGPMSNGGGPPPDLALRERELALRQRELQLREQEISMRRVGRRTSAARDGFDDMDDDDYFDPMDHRGPPLPQIDPDNFDMLSVTSRRNRKTQSQNPGQFRKNPEMGGGGRPPSAFSRHFGGGGRSRTTSRLMDEIPGVHDSLLNNPMMGYSSNRYGNVDRKEIRDESRANSLTASRMNEVGQGNFHPPSRRTSQSPGTSFHPAGRGMGRPPPGHDSYNGQPMLPTGRRPSPPGAKRAPIPKYPPGQGSVAAPQQVEQHVGRGEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2U8</accession>
    <name>A0A179U2U8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02384">
        <property type="protein sequence ID" value="OAT02384"/>
        <property type="gene ID" value="BDCG_07391"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07391"/>
    <dbReference type="OMA" id="ASCKNSE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="760" mass="87076" checksum="5C2626CEDC7D3299" modified="2016-09-07" version="1">MSSHIAEIEDLRRRLEEERRGREQEKRERAQEKERADRNEHERTQEKERADREKRERAQEKERADRNERERAQEKERADRNERERAQEKERADREERGRMRLEADQSPTAFLVYLQHVKEKLLSTFSVEPDPTKTSSGSVTNVHGKYYPQQLRKWADFNKNHNRMFNQFTEVFSNDPLFPPKTDVQGVSRDLSPGSRKDEQDIRPFVRSSMEKPAERLVQAYLRQIKDTRTANFLFQNNAYSLSSKHITDLTDADAIENQDAVPPSKKRSVERDVRGVPDRWGIRGLPSGDELTVFVGEYKAAHKLPSSAFDRVFSSTGESLFFDTLKRLSLPFVDTNKEERVVAQVLCQTFDYMINAGLLYGYVTSGQALVFLMLEKSDPQILYYHVSAVPDCVDDSLLNDFDVRYGPVSQLSTFVMLSLESAPQSPQWIENAKSQLYQWPILPENLILRSRSLRPETAPSSSSDEELEDKKDGSYRPGRQPRNQQPHSQSTDRTETQRRQSSRTQHRSQEPTLSYCTQACLVGLSQGHPLDQFCPNFSIHQRGTSSHNHLISKEKLCILVNNQLARNLDENCKCLDTMGMFGAVGVLFKITLTNYGYTFVAKGVQAVDEKAILNEANVYAHLWKLQGVTIPVHLGNIKLLQTYPLVSTATVTSMMLMSWAGNSLHSEDYKSDVDIEAQKQQSIAELSAAGLVHYDLRRANMGWNQERQRVMVFDFDQSSIQPSLSGRKRVGDGGASSGLAMKRTRVDRDNADVVFDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2V0</accession>
    <name>A0A179U2V0_AJEDR</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01271">
        <property type="protein sequence ID" value="OAT01271"/>
        <property type="gene ID" value="BDCG_04769"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04769"/>
    <dbReference type="OMA" id="EINNFKM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="805" mass="85263" checksum="4D1B8CB41B946B67" modified="2016-09-07" version="1">MAALVQTIPQQTSSITLLQPRPSSSTASFPSSATSTLQQHSQMARNQQPSRASYNNVLGHGNGSGSGMGYRASQAGQPVAPYAFTSTPSLTNTGSSHTRQNAPHLLKTEHRAVSAPSASQSQANPTFPGVIPSRVHFPAAGSVFNSSPNIPSSVISQGSKDDSAIPTKQWTNESAARPLSSMGSTPSLSSTSPTTSTKPSPDRYRRGQRRTESQNGAGNVSSFLASGLSQPSFAPGVKEGNAPYHSRVSSADDAFTANPQSSEQAKRYRRRSLGSLDITGLPNLSEQKPAAEPLMSLVTKDFTLESPDQRPHSAHTYSHAHKGSTESVSSTRSSPPTGKRAPPVSSSTTLKLDHKLIDNSKRATNPSPLSQPIDMSPESSKPKPTTTTNPATESSGPMQAQPPSPSTQAKVHSPAAKRLTELSKKGFHKSGKSRLRRALSFGSVAELRAASAQEPIPQAGRPGQEVSRKQQLDEELGAEQAAIAEKQEANGLGENIYSGQGHIFSGSMDNLSISSTASSASIMLRKMGKGVRRSTRSLVGLFRPKSTPNPEGDTTAPVEPMTPQVSIVNVEAERGNGQQASNNTALEEGNDINNDNEPGAPPSAKGRSSVESGSTATGGDHSSTDSIKVARKSILGGEKERAEVLAAVRKGILKRSGAGSNTSSPTLRPVEFRGGTDVMPVPHIHDSPHSSAPSTPNGDRDRPPRSGHRRTDSVTIEGEDYFLPAGRFGTTDSSSAPVTPQTVTARNISFSPRIQFHDTWPSGEYDRRGDIATCNRLTPLLAQQIKEELNTFKMVSRRLPKSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2V1</accession>
    <name>A0A179U2V1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_05668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01629">
        <property type="protein sequence ID" value="OAT01629"/>
        <property type="gene ID" value="BDCG_05668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05668"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="36"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT01629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="292" mass="32936" checksum="F17B22C4D3F662BC" modified="2016-09-07" version="1">MGNVVVGAVLYTSYLQILSGLHEPTLQATKRIYPPPAPSLTFTAGFAAGGIQSIIAAPLDALQVRFSTNDMMKGQYRNVWQYGKHKLHEIGIRGIFSGWGLSFLKDSFGSALFFGMFETIKSQGYYTFVRYYYGSLQPHRVEKLSVSTAGISSGDIPTIRPHYGLEPCFLMLAGLTASLVQQFVHHPLTLVQTVYYERLEHIDAMAKLDHSGRKMMKHHYEAYLELFMRCQRRALRAGGWRPWLFGGFFGNALRQVPSTSAGLIIFELVRRKYGVDAEVVHIQQDGYDIILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2V9</accession>
    <name>A0A179U2V9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M protein repeat protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_03474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00732">
        <property type="protein sequence ID" value="OAT00732"/>
        <property type="gene ID" value="BDCG_03474"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03474"/>
    <dbReference type="OMA" id="MCKKVAQ"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029605">
        <property type="entry name" value="FAM184"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PTHR18870"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="478"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="826"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="958"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1186"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1231" mass="131723" checksum="86227EF856F92864" modified="2016-09-07" version="1">MASMEEPFIPATEPSLPESSVDETVATSAPTDENEPPAEEPAEQIPSSPAPVKVRTTIAVSPRQKTGTSAAPKRPGTATTTATKRPAGFTSTVTSKLASATTRGTTGSTLNRPPTRPPVTSTTARKPASTATTTTTHRQRASLGSSADERGKSIASSGDESKRAGISATVKRASLTSSVSSRAPARTTSERRSTITPSSAEKRPTTSRPSTAQSPAKPTTTTTRVSATATSKTVAPTTTSRTTRPISGTATKSTASTTSESKRRMSSLSTTKKPSIDTGKPVEKKLIAKSAALQEKIKEYEALRELLQAAIAAEEAGNDEKRDEIQGEIDGDIAQLKGSLDTVREGDESTGASKLAELQARLADSEAKVAELQSQLDDVQSKLSEATKPTEGEADKFSTATDLIRSEHEAKVLELTETHVEELNALQAKLGESESQRSEAESRFVQELEAARQLASQEGALKISELLEQQKETHAAVVAALEADLAAQRDTSAELTAQIVTLKEELATRTASLEEAAKAAAEKEKAALATHQDQVLRLETELKGRDAVIKSLKDEVQTIQDTKDRELAAANEAASQSTVLKENLEALEVKLAQVESESAQVTLTMEKLAEKEEEIAKLSQVIETLQDEIKEVQQAKSEELLKQADLTTAHEKAMAALQAEHDSVLASVTAEHAEELSQAVEKSKTATDSLQQELKALMEKYDAAQAEVASSKTQLEDIAKGASEAHAAELQSLQEKLDATEKALEEVKHQGEEASAAERESNSSSLRELEGKVRTLEEELAKGSTRIKALDDDLQGERARVEGLRKGLEAFEVTTKDKDEYYKSTISRLEVAVNETNDSLKEKTEQLASFEEKHTATLSELTVAHSTEIEDLRAELSGSNDSALKELRARYNELVASNIANDATHATQLETLKAEHATALQELEAKLTQQFEDNKLKIQQDAEGSHAEKLAEIEAGQTKAIEELLGAHEEKLASLRSEHEAATKEKLAAVEEAHAAVVAELKRELEKAKEAAAAYMTEVEGLKAQIAALGEEHAAELSKVQSDSAALQKEVEAAKNDLTAAEAVKEELAAIKQNLSTAESELGSQKQAHAQALADLEELKAAAGDSDEKKSTVEAKFAALEEDMNTLSEKNITLIQQLHEAEASMSKGSRRIRELEFGLAESRLKKPESANLSNGSNAKSSSGLDDSKWAVKEDDMPAAGDEQADTAKVLPEDAGPTTTEDGQHSGTAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2W2</accession>
    <name>A0A179U2W2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_07453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002620819.1"/>
    <dbReference type="EnsemblFungi" id="OAT02426">
        <property type="protein sequence ID" value="OAT02426"/>
        <property type="gene ID" value="BDCG_07453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07453"/>
    <dbReference type="eggNOG" id="KOG1493">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWRWDTG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT02426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="88" mass="10139" checksum="578DB065C8DB0FA5" modified="2016-09-07" version="1">MKVTLREWNAVATWRWDMPEDEVCGICRVHFDGTCPTCKFPGDDCSLLIGKCGHSFHMHCLLTWIGQESSKGLCPMCRQKFDWKQGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2W4</accession>
    <name>A0A179U2W4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mold-specific protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02063">
        <property type="protein sequence ID" value="OAT02063"/>
        <property type="gene ID" value="BDCG_06656"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06656"/>
    <dbReference type="eggNOG" id="ENOG502QUR8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="444" mass="47217" checksum="E177ACD9AB8E59E3" modified="2016-09-07" version="1">MLLVSMGYPSAADRVCYPGKRINICFSHVCLSAPSASSYIPSTHFLAYKVFKIFSASIDSIFNSVISHLLYFSPSTPFKMSYNNSSGSYSTSRRDEDSNNSSNRRDNDDSYGSSGRSGVTGSYGSGGNNNSSSTRRDNDSYGSSDRTGGNDSYSSSGRTDTYGSNKRDDNDSHVSSNRTGGTDSYSSNKGNDSYGSTGRTGGNDTYGSSNRGNESSYGSSGRAGAGSDSHGSSNRNDSYGSSTRTGGNDSYGSSDKNKSSHGSSGNKNDSYGSNKRSDNDSYGSSDKNKSSYGSTGNSGSNNNNSSYNSSKRDDNDSYGSSRNTGKGSDSYGSDNLNKKSSSSYGSSTNRRDDDKSYSSSDRNKSSTYGSTKRDDDYTTTTTTTSTYGSNTNRRDDNSYGSSDRNKSSTYGSGKRDDDDNDTYGSKSSNKYGDRSGSGEKKGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2W7</accession>
    <name>A0A179U2W7_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Formate dehydrogenase</fullName>
            <shortName evidence="4">FDH</shortName>
            <ecNumber evidence="2 4">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_05304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 4"/>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01487">
        <property type="protein sequence ID" value="OAT01487"/>
        <property type="gene ID" value="BDCG_05304"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05304"/>
    <dbReference type="OMA" id="HYTDRHR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009326">
        <property type="term" value="C:formate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="6">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="7">
        <location>
            <begin position="130"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="312"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT01487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="363" mass="39789" checksum="C34BC59A1B59FC31" modified="2016-09-07" version="1">MGKVLLVLYDGGQHAKDQPGLLGTTENELGLRKWLEEKGHTLVTTSDKEGANSKFDQELVDAEVIITTPFHPGYLTAERLAKAKNLKLAVTAGVGSDHVDLNAANKTNGGITVAEVTGCNVVSVAEHVVMTILVLVRNFVPSHEQVASGDWNVAAVAKNEYDLEGKVVGTVAVGRIGERVLRRLKPFDCKELLYYDYQPLTPEVEKEIGCRRVENLEEMLAQCDVVTINCPLHEKTRGLFNKDLISKMKKGSWLINTARGAIVVKEDVADAIKSGHLRGYGGDVWFPQPAPKDHPLRYVQGPWGGGNAMVPHMSGSSIDAQVRYAEGTKAILESYFSGRHDYRPEDLIVHAGDYATKSYGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U350</accession>
    <name>A0A179U350_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01567">
        <property type="protein sequence ID" value="OAT01567"/>
        <property type="gene ID" value="BDCG_05541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05541"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="PTHR22792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="684"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="901" mass="96997" checksum="40C255CA10CB4DB0" modified="2016-09-07" version="1">MSTSTSRPGLEMPAFSYAQAAKGFSTPPSVQIVAEKQNKSSTTSSDPSSHRTATGSVDGDGSNRTVASSTDLESSSVATEPADATDKSQSSSERSSDWTVTPPAAGAPWKTATSGTSSPSVGTTSTTTLPKEDDTSGTPNGIPDSSWDKQSQVSGTVEKSSESGESGKEKLKENGWEKDVPVLKELKAAPIPAVNVWQQRREAQEAKAKASAALKSTTTAAAKPFNSKSSVPSENRAEGSKGGPRKKAGGSEVAADAAIAKKKSSESGKSKEEAETLPPVGDASSWPTPQLAQGEEFRKAQEKSDKTEKSEKEKAPTAGSRGKEKWMPVPYVPTAVFNTPLPPAARRGGRPSRGGREGGMRSGAHPSAAISSSDRSVPASASAAGGSKQTGSSDRGRSGTRVDSDQSGTTQPARTGSVNAPLSPDEKKAPHDSRPDRASSDSKSVKAPEEPRGTTGGETQTNHPAAETGPRQRQNSKSFGRSHDYSNVTSQRGTEHTGRHAGVQGDSHAGTRFSSGHERRFDNGPRSAEFYKEPPFHPRDRELSNQREREYPRERNDFHRDREYGRERGESRPERGRGGYRGRGGHSNYSGAHNSQYHSPPVGQSQFQSTKPFSLSERHRSHHQASQNGGQQHGSNRGLNMRSPSLPSSGVYGPTPYPIQTDLNAMYGYPVLHQGPMTAIPYHPYMEHSLMSMISMQLEYYFSVDNLCKDLFLRKHMDSQGFVLLSFIAGFKRIKSLTEDMDFLRLVCRQLKSVEYRPGEDGNDRLRKREKWEQWILAMENRDPSAQNEGPPPLSLSTPAHDGNSDGLNSSHLETTALYGNGSLHEISGNAIPSHYSLSNGATSDTRVHQSVLSSAAPEFSPAYVPVTGQNENANVGKPIKDESTFPDEQIENLVIVRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U367</accession>
    <name>A0A179U367_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_05945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01749">
        <property type="protein sequence ID" value="OAT01749"/>
        <property type="gene ID" value="BDCG_05945"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05945"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="124"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="413" mass="47464" checksum="CFE5623AC0AD41F2" modified="2016-09-07" version="1">MGNIARHTNQWCRTDAVPWSGCWDCRTKEDSCKHTAASYLLAGEVVVRVPISEMLTIKSVPSTFREKFPDNIPVQGLYAAYICCTEEFQDRYAPWRAVWPSRQDLGQILPTLWPQLLKGSASGRSVSSLSYPLLPPSISGSWNTISKRPIKHAYTAEHQNLLPEQEKRLDKAYHIVKQVLQDVDKDLYTYYWLIVHTRSFHYIPAGTSPPKDHNDAMALCPFGDYFNHIDEGGCEVSFDNDYYTFRTSKSYDKGEEIFISYGNHSCDILLTDYGFIPAVNKWDDLFLDDIILKDFSSKKIEALSIDRYLGNYQITTKGPCFRTEVAACMKYMTLDDWNQYILGYQPASFDQRKTNSIIAAWIHEYIHEAEVAISKLTALRRSRKYGGEPQFDVISMRWKQIVELCNAVLKTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U375</accession>
    <name>A0A179U375_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_05973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01759">
        <property type="protein sequence ID" value="OAT01759"/>
        <property type="gene ID" value="BDCG_05973"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05973"/>
    <dbReference type="OMA" id="AMKACIA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="294" mass="33317" checksum="B052184DBE2C96EC" modified="2016-09-07" version="1">MLNARSKAAILNPSLPFESSGSAPNMDQVHFLESANVATVFDNALPHTLGELSATAKDVLKRQAGVLLASHKSCPQDKFRGSVKLFLEGGIFTEESALRITPRTQNRHAKSATKGRLNDVQRLMQLYNVHPKIEDYSNEPISLIDKIKIPGPEYIPDALRELVERKILLKEEEATHMANEFSEKYGSESLFRSAFREFFSTGLIGVQQTFWRPDPRSQRIRRQAEEICLQAIDESLWLNGAEILFVIRATRCFPEDAMSFWRWVSANRLTYLAVMDMIELQGGFLDDPETVQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U376</accession>
    <name>A0A179U376_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 transcription factor, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02260">
        <property type="protein sequence ID" value="OAT02260"/>
        <property type="gene ID" value="BDCG_07119"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07119"/>
    <dbReference type="eggNOG" id="ENOG502S48N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="PTHR36167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="407" mass="43893" checksum="2B08069EC835E705" modified="2016-09-07" version="1">MDRPASDYAQPGLHSPNPTLAEPQSERPAAEQTAAAASGQYTSQPEARPATQYTAPAEGRPSNISSSNTPQPDYGLNPPAPAPPQTQPQQQQQQQHQAQAQPQPQAPPPPAARPPPGPYPEYLTRQPQYHHAPHTQPGGAAGMAQATNPSIAASSPTYPPPYSPYNPQGHEMTQYPGHPPPQMYGRPDWPPHQYGQHPHGLPGPYSSPGTTVGSASPAATAGPRPGQVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGAKRTPEEFKEIRKEWKARKKEEENQRKAAEERERAAAQANQQVDGSAPADPSQAAQSTSYPGGIRPQLPPIGYQPADGQVPGQYGASAGAGLVYPPSNGQMAAPYPPANYPHSPYGQGNQVYQPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U382</accession>
    <name>A0A179U382_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01411">
        <property type="protein sequence ID" value="OAT01411"/>
        <property type="gene ID" value="BDCG_05156"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05156"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="PTHR14221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="389"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="757"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="822" mass="90996" checksum="3FFD8034C678022A" modified="2016-09-07" version="1">MDQDGGMHRRREHDGGPISEVAGNGASTSHSSPLLQPPDARKASRTSTANTASYKAEERNLHNDSKPPLVKSHTAIPTTKPPVAAAASPSLSQPQFKLSSTSNQESQCQALIDPLSQHILQRTNTDRSNPPRLRTQGKSDTEPGGSEFQWALTQEDSSSGILREASLYQKNSKEKKKGVSFLSRIIGSKKKTSAEWKDDVSETGEIRATGMDAEVFAQPIGFIPRYPPPPKYIKVRSHYKKDKDFNRLFIAQELCGTCSSTKNKSLDGKDSSTGSEEIPATGKAIWALEFSEDGKFLAAAGQDKKVRVWAVIATREDRQAHEIEEEAQNDKPFIRLRAPVFKFQPVREYESHTASIVDLTWSKNNFLLSTSMDKTVRLWHVTRNECLCCFKHNDFVTSVQFHPQDDRFFLAGSLDSKLRLWSIPDKSVAFVTTLPDMITSVAFTPDGKYSIAGCRNGLCLIYDTDGLKIHSQIHVRSARGLNAKGSKITGIDTIVQPPNNPNGLVKLLITSNDSRIRLYNFRDRTLEVKFRGNENHSSQIRATFSSDGKYVICGSEDRKVYIWPIASPERDPEKRAVEIFEAHPSVVTTAIFAPNKTRQLLGATGDLLYDLCNPPPITLVSQAPSVASKPTTDAGGSREGSLAPTPRSSTFPLTRKPEEFQPPSTKFSHPCGNIIIAADANGTIKAFRQDCGYHKLRSDVWDTGFSRRILGRNNSFSTRHSIASSLGKDSIHKTPSERILSWRNTVMGAENSSFDNLRSSLSMRTRSISPRKSSTKQKEKNKDKPQRGRGQGQGHNPSVVFNPAEEPSIPADTARTTYQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3T1</accession>
    <name>A0A179U3T1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sphingosine-1-phosphate phosphohydrolase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01817">
        <property type="protein sequence ID" value="OAT01817"/>
        <property type="gene ID" value="BDCG_06112"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06112"/>
    <dbReference type="OMA" id="ADDCPCY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT01817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="522" mass="57158" checksum="30DB326ADD8D31FB" modified="2016-09-07" version="1">MRTPSLDSWFAITANLGTHTFYMVMLPILFWCGYTEVGRGLVHLLASGVFISGWFKDMLCLPRPLSPPLHRITMSGSAALEYGFPSTHSTNAISVVVYALHLLNSPDSTASPVTNTIFRIVLYIFGTSIVIGRLYCGMHGFFDVIIGSFLGALLGFLRCSYGETYDEIIYSGSINTVFAVVVVVLALVRMHPEPADSCPCFDDSVAFAGVLMGAEFGNWHFAQTTFAWGDPYPGTVPYDLAKVGWIKTILRIILGVVIVFLWREIMKPSLHRILPPIFRVIERLGLNLPRRFFTLASEYEQVPGHLKDDDIIPNVSEIPSILTSIRHPRRRAISIGPQSEADAYETLAYREKRRRESTSSNQSRSVSAGRRLPPTIEDKQNMRDTSSASSPAAGGSQRFGGGENNPAVRSPRKLDEYEHMMGTGTPVFSAESTPNMDGAGGADGASGASGTGANADVNVNVAADALEYQLGAEEEKEMFSKITPPRVRYDVEVVTKLVVYFGIGWLSVEVNPIIFQLIGLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3V5</accession>
    <name>A0A179U3V5_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAD_SAK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT01999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01999">
        <property type="protein sequence ID" value="OAT01999"/>
        <property type="gene ID" value="BDCG_06511"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06511"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
        <property type="entry name" value="HAD_SAK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAD_SAK_1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="638" mass="69848" checksum="9EB770E672B14379" modified="2016-09-07" version="1">MATPMVSGPLHSEGRKSTYTTTALKRWSCQSGGELPAVAQVKAIHVYDFDNTLFSSPLPNPQLWNGPTIGFLSTYECFANGGWWHDPNILAATGKGMEVEETTGWKGWWNEQIVQLVELSMQQKDALTVLLTGRAEGPFENIIKRMVKSRKLDFDLVCLKPEVGPNSQRFSSTMNFKQTFLEDLVLTYKHADEIRVYEDRIKHVKGFREYFEKLNRSLQLGPPSTPRKPINAEVIQVAEEAAFLPPVAEAAEVQRMINSHNKVLTSTSGNTTKSPYGRLRIKRTVFFTGYLLSNTDSSRIINYVLNPLIPPNMPDSNDIKYMANSILITPRPISNSILDRVGGMGKTVRWRITDTGVFENKLWAARVTPVLDSEIIYTENPEPLMVLAMRKGARPADANRIRNWQPVIEDNALVFDATVGQKMALMIEEEHPDEGEWETLPKSNNKRRLVQQNLRDDEGAPLPSYLRDWNNNNNNSPNNPNLRDREPVPRNYAPHHHVHVPHGPSHGQQEFPPYHRNNPPYSRHHGEGGVGGGGSGGGGGGGRHYGDEGGAPPRRGGGGAGSNYRGSRGRGRGGRGRGRGRGGGGGGGRDGPPGSHQYRSLDDHAAGGGSGGGGGGHDGHGTGDERGFGGGGGPVMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3V7</accession>
    <name>A0A179U3V7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_06206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01857">
        <property type="protein sequence ID" value="OAT01857"/>
        <property type="gene ID" value="BDCG_06206"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06206"/>
    <dbReference type="OMA" id="DADNCAE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="164" mass="17702" checksum="C57370BBF4EB3866" modified="2016-09-07" version="1">MPTTVTGFEPEPRHICFDETPKLHCYNGGNDIPQNVAAEDVSFIASYLRAYGRQTRIGRLFTMKAADAPDCGEWVLYACGTAAAYAKKINMTYDSSILFADIADTIDGGKKLEADSILKCNADGGSLGTQIADLAAPAYLTKEYVDGHFKPDGIIIKIVSNKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3V9</accession>
    <name>A0A179U3V9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoporin SONB, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_08173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02724">
        <property type="protein sequence ID" value="OAT02724"/>
        <property type="gene ID" value="BDCG_08173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08173"/>
    <dbReference type="OMA" id="KGFEWPY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037637">
        <property type="entry name" value="NUP98-NUP96"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="PTHR23198"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF17">
        <property type="entry name" value="PTHR23198:SF17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="SSF82215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="9">
        <location>
            <begin position="863"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="732"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="840"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1165"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1227"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1266"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1889"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1101"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1173"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT02724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1970" mass="210522" checksum="1C139A1772C6D472" modified="2016-09-07" version="1">MAFNTGSSFGGFGTGNQQQGTGFGSGTGFGGSSTGTGFGTNTAQSNPMFGSQNKGFGAGTTTTGGNLFGASSTPSTTFGGSGFGSGGTGFGGTATGTTGTGVFGSTQQQPQQTGFGSAGQGSSMFGGTATGGTAFGQAGSAFGASGTALSGAVPPAEGTANPPFSAYTEKDQGSSITSHYQTISAMAPYSKYSFEELRVADYQHGRRYGTTTGQTGFGSSAFGGFGQQQQQPPTTGAFGASTTTTPFGAAATTAPTGFGQTQTTGFGTGTSNPLFGASKPATSLFGAATTSQPSGFGTTATTGGFGSTSNLSGATLFGSGTQQNRPAFGGTGSAFGGFGQQGTTTTSASPFGGTTATAPAFGQQQGQQQTTGTGFGFGQTQAQTPSKPLFGGFGGTTTQQQQPSTNPFGGATTGTSGLFGQTAQQQPQQGTSLFGNTANQQTGTTSLFGGGNQQQQQQEQKPSLFGNLNAGQTTTGTTPFSGFGAQNTQQAGTSLFGSQAQQQQKPSLFGGSTTQPAFGQTANATGGGTSLFNLGGAGQPQQQQQQQQPVGGFGSSLLNQSQQPQQQQATGLQASLLDGNPYGSQSIFSGLPPPNAPSPGPLATPLSATIRQKQRTPLPVYKISPSAANRLITPPTRQGYGFSYSTYGTPSSSYSTPSALSSSLLGGSLRGGSLGRSFNKSMSTSNLRKTFDGSTDSILSPGAFSAGTSRYSNANLKRLTIDRSLRTDLFSRSTQSPSLTNGEDQGSSKLKKKVSFDSQTTGGDSGAEADGSVVRVETESPEPTAEELGFLRSSRKQPAGVNGTNGTVKDVNGVNGAASNVPEMEQVRGNELSIVPEGREQDGAAVSPPGEVPAKAPGGDPKPGEYWMKPTRSELSKLPREQQKRFVGFTVGRAGCGSVTFDEPVDLTTVDLDSLFDKFIKIGTRSITVYPDDVTKPPRGKGLNVPSTLRIENSWPRGRDKKAPSHMTSGPTFDRHVERLKRVTNTEFIAYEKLTGTWVFKVPHFTTYGLDYDDDDDEGENFDQSTLSAPPPDTPTPKAQTQTPTQSSFANSEFDSTISLNESYMDDSTTGMEDDTFEFKKRKLVPGAFLGQGGNDGGMEDQAMDTDEEELDQDSFLDDDRSSASRSETGSLEQTNSQDGTELEGLSEDDNELDVTMVGAFPAPDHSMEQMMHSSPLKPTTTFQRPDQQHGSPSQAHLDLGGNWAEQLQRTISPRKQNRQALREIQGNVFTDLNNEDGGSTPTKSTRPARETAGFATSIDLMNSLFPQAKSSGGQGRPHKDAKAKGFQWPYPKQSKTVGGNVKDMSENDIMFHNSFKPKFGCMDNLICPRIPGSIGRSEAPWNQAGALSSDGRTIVLHKYDQPTSPPSTLDEQKSRTNILVIDNVPFARLSKADFSALADTVRDNSPAGDLERQVWQLANVLFNDDIHDDISAGVPKNLRHQYLHRIKKDRLSRLWQSIIRDRHSNEIANIESPEERAIAYLCSNRIDEACKTLVESRNLHLATLIPQIGRNSTVRRDMQEQIESWRKHNVYSEMTEPIRALYELLAGNCLRSDGKPGGALEDRASTFYLSERFELDWIQAFGLRLWYGIDEGASIEAAVELFHHDITHGNEPAYPFSAVSGDSSRDDPLESPLWVMLKSFTAVVGRQENRKIPPIHLPEAILPDALSGTPLRNRFSFQLFHHLQALMGHLDAAVINEARGDQLTWDYAWELAALEQFPSSIFVLEHLLNSSQRERSIKELLSRFAAWLPVRTFDDGTPNPLWNYIVGDLQVPTSWIWVAKALYARAQCDPSSEVQYLINAKHWNEAHETFRRLVGPRTVIERDYATLGTLLSGFGESPERKVRGWVTGGAIYDDFLHLITAKGARREPSRLKRLVSALAALGLKMESEKGRDMDKDENRDSPSSASVSLEETVAFREISHVVAGWCARDTRSTIEPSAILNLLLTQDTRLLHTAEMSRRYYNIIMATAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3W2</accession>
    <name>A0A179U3W2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_05788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01671">
        <property type="protein sequence ID" value="OAT01671"/>
        <property type="gene ID" value="BDCG_05788"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05788"/>
    <dbReference type="OMA" id="RMDDTII"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="412"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT01671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="888" mass="96722" checksum="5221FDF502D096D1" modified="2016-09-07" version="1">MMNHHLPPMHHGQPPIPAPRRQHEIPYVSGPPNIRSTPGYMGYHQPHAHANGPPTALHPAQAQQYQHWYPYQQAPPPHPPPPQQFQPNTLLIVSSYPRSQPPLPTLSGPHYTHSHIPSHSSTTSSTPLQSSFSPTPTPPSAPGSAVQSSHGNLPASPVVSSLPSQPLPWLSVPEAPFPARAPRRRRKARILQTSTVRVEFSTNAEQSDVAAEECTPIECHSKNAPSELEGEAPASPQPSSETSPVQPNTPSSTAPVQTSAQSQHTPAQTSGARQAAPIVPIVPIIPSSPNTAKQPSTSTAKTTPETLKRDGQVPLSSTPDGARTTDNALSPTESATVTQEAPKPTTPVRAPPKSWADLVRTAAPTATSGASPTTTGIGGLGVSKGESLFDVINNLGSNSERDGGKIAFIEPRGLLNTGNMCYMNSILQILVFCVPFYEFLDKIGRRAVHSFKSDLPLIDAMIMFMREFRVIDAATSVEKLRLRLKQNELELYGESFIPEYVYQVIRHLPRFRDMRRGHQQDAQEFLGFLLEELHDECTQAVKQATSTASDISTAVEADFVSATSEPSVEGWLEVGHKQKPAITRSSGHISAESPITKIFGGKLRSEFRVPGNKNSVTLEPYQSLQLDIGSPQVNNIIDALKGLTKPETMQGDFNSSRGPKVTATKQVFIESLPPVLILHLKRFQYDNVTKGTQKIWKKVGYPLELELPKEAFPPHRRNIISAQGSGLPKYRLTGVIYHHGKNASGGHYTVDVRRQDGREWIRLDDTVIRRVRSEDVANAGSEEDPKVLAAALEQHKIANTTPQGNIFEQFDMEQQQRHENEQGWSHVNGHTSGSGSGHAGKKSMAAVVNGTTSPSGESSSGKRTPSSSRYGSGVRDNKVAYLLFYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3W3</accession>
    <name>A0A179U3W3_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02009">
        <property type="protein sequence ID" value="OAT02009"/>
        <property type="gene ID" value="BDCG_06549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06549"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="210" mass="23828" checksum="8F75AAF1F325E643" modified="2016-09-07" version="1">MAHSRKHQQPQYTSYHTPRSQYPLPTSVAPAMSYSSSTDSNSSTRTASSMISTSSGHQQQTAYYSSHYPTTSAGFTDPIYQQQQQQQQRQASASYTTSPEYVLVTEEAATTPSRPARAAGLERSGSRYVCMFPRCESSFSRSADLSRHYPTVHFPDSVRLDCPKPRCSRKGEQGFTRQDHLNEHLRQYHKEPVTKRRSSKSSSQRPETYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3W8</accession>
    <name>A0A179U3W8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02734">
        <property type="protein sequence ID" value="OAT02734"/>
        <property type="gene ID" value="BDCG_08206"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08206"/>
    <dbReference type="OMA" id="RAWASWN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="404" mass="46446" checksum="71C1C32E1E632473" modified="2016-09-07" version="1">MWRMLIDVVRFNHFALDSLRGEQPVKRQRSRKWKNIQQPYQHEQSQKSIGAYLATEGYSNSFRDNYIIPLIAVLWNVHNARDALELPIALLLRFMANCDILRSSLWWSEWMIVAGGKADFAAATTNISATERVHFNTTIKSVKTSDRLGWLAVQGEQGRTEYFNHVIIATSAHNALNLISADATDEEVRALSGFQTASSIAILHSDTALMPKRKRVWAAFNLITKSSQRNPPDTSQFCTSFHINRLQGLSEEIFGPVLITHNPISPPHPLRVQGIWEYSRFTFNNRALRSHKLLQRIQNTRGISYCGPWTGYGRYEDAVRSAFQVAVDHLGAELPFGVLGDDPFLPSYPDAMEWSQVEALAKRERLARFLVRFLLVIYWFLGIVRRVVLYFHRAWERGDKTRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U454</accession>
    <name>A0A179U454_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02109">
        <property type="protein sequence ID" value="OAT02109"/>
        <property type="gene ID" value="BDCG_06794"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06794"/>
    <dbReference type="OMA" id="PKHTVVF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="2">
        <location>
            <begin position="797"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1126" mass="122248" checksum="FD66D856C02BBDB4" modified="2016-09-07" version="1">MPGVDSGDREDDAWEVGKNIPSQSSRTLLPRPVASLVSLFTHSTSLSLRIGTFLGGFALDSARATTLTGLELSRAVVESILVRAGRDVALQSTEYGRAQAESLLERSLATLHSSITSASFFASAGFHLSSMTLNSFSDFSQNLLSTLDAILGSSESSRAIAAIITLIIREFRSKESKYGGQRAGVADLLVGSTGFALLQRWGRRATEREMRDSGKEETVWDVVILDNGLRADVVGTQQIGYPEDIDTGPTRASTRASSFILPDDTDRADVFRSVGHDTARRNTLGTLLPHVSLPADHQHELSDEEIRVYIMNQLPEGTRASINTDTVTSRTITVDFYDDDVVDLSPPPGAAMIAERFHHLHDVDPGDTTRGFVSHLLKHTVVFRTSSNHSNSAELRKELSGTLYSSADRSSASGPHSSNKRKPKKRGDISTTSDPSFNNTMTIPDSCAENTNCPYGANLSSSMIDSGLQQGSLGKGSLSNFTQKDKQDNKSDDENIALHNASRNPSLKNPAGKSNITETAQPTSPMAKRLYYTEKALPRVPSKHESLNHKRSFGNLINPHPNGPRMRSPSRSSYISVQGKTVDSYTAQTDAYSLHPTGSPPSSPTKARNHVRSSSALSRTLSEKDIAILVNDDENPRPLTPHRKGSIKSLAPSTYSIADAGSETSLVLATRPTKSVYEDQATILALQRDGRVPGVFPDDHIVKNIQRFSRFSSASYGSNFLRVMGIGNKQPWQKDEFISDDHHEHCSFSKHTGLPASTILLSSFVDPAGGSNAAGETAEGFPLVHYLSLDHASKAVVLTLRGTWGFEDILTDMTCDYDDLYWLGRTWQVHKGMHASARRLLEGGGGRVMATIRAALEEFPEYGVIFCGHSLGGGVASLLATMISRPKDADKSGPSFVTASKPSSGISLLPSSQQRGQLFLPAGRPIHVYAFGPPAVMCPSLRLATRGLITTVVNGQDVVPTLSLGVLLDFHAVSMAFKSDMSDAKAHVRSRVWESITARLVNKFYVDRPPLLVHAGDRVGEDSWAWATLKSLRETLVAPKLLPPGEVFVVETMRVLQRDAFTLDAFGSADGSPRLGRPATRVQLKFIRDVETRFREVRFGSGMLGDHSPGRYEASLAVLARGVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U473</accession>
    <name>A0A179U473_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain-containing protein, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_06836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02128">
        <property type="protein sequence ID" value="OAT02128"/>
        <property type="gene ID" value="BDCG_06836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06836"/>
    <dbReference type="OMA" id="TYAMQPD"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="SSF57701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT02128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="357" mass="38633" checksum="208739A17DA8AC8B" modified="2016-09-07" version="1">MEVDPKTSQGLTMDATAGSAADKKRNKLGYHRTSVACVHCRRRKIRCLLASDDTRCENCIRLKKECHFFPVDQQPPVEPKRSRAGSKAGTTSTEASITSSPPALVGGGLMDQTDSYFQYAPMSINSGQDISPFEPGPYTATPMSNFSPDPLNTHDLSAVQPVSQPVPWDGSSYFDQNLPSAMAKSQMTTPTNTLWNHIPPVAPLSTAPSIPGTPLTPGILPSTGDPTAFGMTDSSVWPAQPTRSVTLASGNLAQYQNQYQQQIPPEFKRRMTAPGETYARPTNTSVPELPSSTAPVSYTQTQSSVGYSSWEAYQGQPTVPANPNQPVIGSTPYGLGGWYAADPQQYARMKQDEYHNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U474</accession>
    <name>A0A179U474_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002623149.1"/>
    <dbReference type="EnsemblFungi" id="OAT01781">
        <property type="protein sequence ID" value="OAT01781"/>
        <property type="gene ID" value="BDCG_06029"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06029"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="293"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT01781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="995" mass="108479" checksum="D0D17C3558304761" modified="2016-09-07" version="1">MSRRPNHLLPKCGCWYSASGTRQYIPQVDLKAHSTILSTSSRTTLTQTFINPTSGELGDVKYTFPLHDGVSVVGFKCEIDNRVIHGLVKERQEAKLEYQDAVKKGQAAALLEQSALASDTFTTSIGKIPVGSKAVVQITYLGELQHDSQADGVRFSIPAIICPRYANSSVDTGELSQSLASFVKKGAINITVDVSVDRGSTIRGLHSPTHPVAITLGRTSVAAQDLFEPNLASAAHTMQQGNAFFDTDFVLIVNAKDQDVPSAFVEKHPTIPNQRAVMATLVPKFNIPNNNPEIVFIIDRSGSMTGNIKTLQSALRVFLKSLPVGVKFNICSFGSRHSFMWNKSKTYDASSLKAALQYVDSIAADFGGTEMLEPVKATVKNRLKDLDLDVLLLSDGEIWDQKTLFAYLNEVVSEQPIRLFSLGIGSGASQSLIEGIARAGDGFAQFVGDNEQLDKKVVRMLKGALTPHIKDYTAEIVYENDGGEDFELIEKPNAIPTGENFGRPAERSAEPIEVDSQKETPQSKEPISLFDPSYQEPDIKSITVPLDANLPKLQPPKVLQAPYKIPTLYPFTRTTVYFLLSPDAPSAALKSLVLRATSKHGPLMLKIPLEDIGQGTKLHQLAARKVTLELEEGRGWIYHTKNEKGQLIVNEHESKKEDIVKREAVRLGIQFQVAGKYCSFVAVESTTDGGKADKKAEAGLPGIRNHPISETAGDRDHTDDEESSDGDTGFVMDYDQEEYTEELCTMPRYSTMYSPLGEPLASGGFGSPFSTSSSSHTQSRFAAPPQSASTRLFGSAPPPPGQATSSPFGPPAVSTSSGIDIPLKRGERLDGIVSKSDDLAKSANVFARKRSSVVPSAKQKLARFFKSESEPKESKSPQDKVHALISHQSFEGSWMWEDNVFAIMDLNASEAEKKLDWAAILGKQSGVGSKDTKQRSIVATLVVLAYLKKKCLDEKDTWELVGDKAMGWAVERIKEIGGNAGQGSDELLRLFDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U477</accession>
    <name>A0A179U477_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01272">
        <property type="protein sequence ID" value="OAT01272"/>
        <property type="gene ID" value="BDCG_04769"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04769"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="659" mass="69177" checksum="C351F03EAC017FE7" modified="2016-09-07" version="1">MAALVQTIPQQTSSITLLQPRPSSSTASFPSSATSTLQQHSQMARNQQPSRASYNNVLGHGNGSGSGMGYRASQAGQPVAPYAFTSTPSLTNTGSSHTRQNAPHLLKTEHRAVSAPSASQSQANPTFPGVIPSRVHFPAAGSVFNSSPNIPSSVISQGSKDDSAIPTKQWTNESAARPLSSMGSTPSLSSTSPTTSTKPSPDRYRRGQRRTESQNGAGNVSSFLASGLSQPSFAPGVKEGNAPYHSRVSSADDAFTANPQSSEQAKRYRRRSLGSLDITGLPNLSEQKPAAEPLMSLVTKDFTLESPDQRPHSAHTYSHAHKGSTESVSSTRSSPPTGKRAPPVSSSTTLKLDHKLIDNSKRATNPSPLSQPIDMSPESSKPKPTTTTNPATESSGPMQAQPPSPSTQAKVHSPAAKRLTELSKKGFHKSGKSRLRRALSFGSVAELRAASAQEPIPQAGRPGQEVSRKQQLDEELGAEQAAIAEKQEANGLGENIYSGQGHIFSGSMDNLSISSTASSASIMLRKMGKGVRRSTRSLVGLFRPKSTPNPEGDTTAPVEPMTPQVSIVNVEAERGNGQQASNNTALEEGNDINNDNEPGAPPSAKGRSSVESGSTATGGDHSSTDSIKVARKSILGGEKERAEVLAAVRKGILKSELIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U484</accession>
    <name>A0A179U484_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase GCN5</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_04792</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01282">
        <property type="protein sequence ID" value="OAT01282"/>
        <property type="gene ID" value="BDCG_04792"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04792"/>
    <dbReference type="OMA" id="IEYRVVN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
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    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47370"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="214"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAT01282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="310" mass="35930" checksum="7227B61D30C7050E" modified="2016-09-07" version="1">MPKDYVARLVYDRAHLSMAIVKMPLEVIGGITFREFRDRGFAEIVFCAVSSHQQVKGYGAHLMFHLKDYVRATGPVMHFLTYADNYATGYFQKQGFTKEITLDRSIWMGYIKDYEGGTLMQCSMLPRVRYLEVGRMILKQKEAVLAKMRTFSESHIIHPPPPQWANGLTVTSIDPLSIPAIRATGWSPDMDKLAREPRHGRHFNELRRFLNEIQNHKQAWPFLVPVNRDEVPDYYNVISSPMDLSTMEERLECDSYTTPKDLVADLKLIFSNCRQYNDASTVYAKCAVKLEKYMWSLIKKIPEWADLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U489</accession>
    <name>A0A179U489_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_06555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02017">
        <property type="protein sequence ID" value="OAT02017"/>
        <property type="gene ID" value="BDCG_06555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06555"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
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        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
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        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
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        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT02017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="177" mass="19045" checksum="624FA7381321C34E" modified="2016-09-07" version="1">MAEAIFRHQITSTAAATAPSAPKFSTIDSAGTGAYHVNSQPDPRTMSTLRDHGITSYTHAARKIRRDDFFAFDYILAMDGDNLDDLMHERGRAVGRGKGGKGGKGDGDGDGDGHVAQVRLMGDFLPDGSVVEKVGGGEEVGDPYYGGKEGFEVVYRQLVRLSGGFMKFLERQGEVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U494</accession>
    <name>A0A179U494_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01292">
        <property type="protein sequence ID" value="OAT01292"/>
        <property type="gene ID" value="BDCG_04810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04810"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="659" mass="73314" checksum="8C7F52EFEB1F3DD0" modified="2016-09-07" version="1">MEPTVVDDNMEVASDAGHTHPGNIDDIEIDLDLAQECVPEQDDDVLVDDASATASDHPTADANITYDADMADGEYIDGDILASGYDQYQQSYYQLDEDSAYNNPMDYEAEMEDDYEEDIDAPIPDSDIEETDIPTTKEVKEEREAEGGEEEKEEGKEIEEVKLAEDAKSPAPETLSQLDHVETEISNAPAVAEEHLATREDTTIAQPKYPKEFTVEEGNDSSQGVENADVAHLSGDFKKYGEDVEPDLEDLHGHSQTEPEPQNTTAQEPEHQETESGGQKLPPLDQENQSDTTESYHFVEAQDYETQGEVHELQKSSSLHPVKVLYQDSEISLFPPGENDPTETFFLQDEGLANAPVAELVGACRQVLGEHISEDEELILDIESLGLHLPENSVPIITTSLVQIIQVYLDLCSNDGINEPEPLYITLSSRPTFTAEFARLAASANEGKGLSYLTWEDYDIDKAEQGVEHEAEDEEVHEQPLLTTEDTGSPAEPYSRLVEPADEEGISSESVTRSPRHDSTSRSPEIKSPEQHLLAQAEPEFCAPTDENDQVVHDDFPTKTPSHGSIESSQNAEECSDTEHGQGEDRGREKARVHEEDNLKIEHGEVTTEPQDSGSQSPNLPQTMKIPTVHLSRDESTDQQSEERPHGKPYRLFRQWIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4X7</accession>
    <name>A0A179U4X7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02041">
        <property type="protein sequence ID" value="OAT02041"/>
        <property type="gene ID" value="BDCG_06615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06615"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="460" mass="51169" checksum="C757E87BC275127B" modified="2016-09-07" version="1">MLAALFEQRQRLEVNRRRSTSSGYGRIRQHCINIYHALNQAWGCCCNPGHIANLHLSTLTVNEMAFPADIRLRIVFQAMADQNTVTARWQWQQAYIQQVKMPESKPSERPVSTSFISSAKLSKKLPWLKQKKKVTFALPAKEKESLSPSTPSSSSSLLSTATTLALPAPTSKPPPPPLTPTNAPSGLTMISNLCATLSSLTLEKSPSPTQGSCIGYLQGHCGLPHELHLEPPDTDWEVISLHDAIQVYLSNTPSSQGEKPGSQVSSPLRRIKPLTRKERFKLAVAVSTSVLQFDDTPWLKQPWGTNDIHFFVKPFSSMPEQAYLSTAFSQTSQIPTNQQSRTQYPPLIRNKALFTLGIVLIELAFGKSLKDLRTDKDVEESLGMPDLVDTFTIKRLLEAVEDEAGYDYSEAVRRCIECPFDGKEARFTNESFQRAVHNWIIEPLKVSLNNFCGSANAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4Y5</accession>
    <name>A0A179U4Y5_AJEDR</name>
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        <submittedName>
            <fullName evidence="3">Nucleolin, variant 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDCG_08574</name>
    </gene>
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        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
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        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002628857.1"/>
    <dbReference type="EnsemblFungi" id="OAT02880">
        <property type="protein sequence ID" value="OAT02880"/>
        <property type="gene ID" value="BDCG_08574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08574"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12448">
        <property type="entry name" value="RRM2_gar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034276">
        <property type="entry name" value="Gar2_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="342"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="489" mass="50603" checksum="BF0B12198D92EFC7" modified="2016-09-07" version="1">MSKTKSTTKASKGGDKAVSKVKSGSVTKAAVSAKSKGKEVSKKAVKEDKKKKKAPTPSESESESEASDSSEASISESDSSSESESEAEMKPAAAKAAVKPAKAAKAAKAESESESESDSESESDSESEGSSSSEDEKPATNGAKVETNSTIEEKKPAAKAVAKESTTEESDAESGEESSEGSEGSSSDESSDESAEESEEAESAEAEKPSSKLQKRKAEDDEELAAPKKTKVESSEGGNLFVGNLSWNVDEEWLRSEFEEFGELSGVRIVTDRDSGRSRGFGYVEFVNAADAAKAHAAKKDVELDGRKLNIDFANARSNAAPRERAQSRAQNFGDQASPESDTLFIGNISFSADENMISEAFSEHGSILGVRLPTDPESGRPKGFGYVQFSSVDEARSAFQTLNGADLGGRPMRLDFSTPRQNSGGGGGFGGRGGGRGGGRGGPRGGGGFGGGRGGGRGGGRGAPRGGRGGSTNRGGFGDYSGKKTTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4Z3</accession>
    <name>A0A179U4Z3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_08266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02753">
        <property type="protein sequence ID" value="OAT02753"/>
        <property type="gene ID" value="BDCG_08266"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08266"/>
    <dbReference type="OMA" id="TIRTWPL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="307" mass="34367" checksum="311DD6BC0C3799CC" modified="2016-09-07" version="1">MTGKTTALYRGPTAPLTSICFSPDGTTIFAGCWDKTIWSWDVASRTLRQRYKGHADFVKTVVSQRLDGEDLLLSGGADGEIIIWSIRTGERLHVFRDYSRGVLHLAIDPLVSDEDPTRITVFSSGSDRSIRHFPLSAPFKEQSLSEPILEHETSVYKLFFDADGDLWTASADKTAKCISRESKWKTDMTLEHPDFVRDVVVHERGGWVVTGCRDEEVRVWNRATGKLHHTYSGHFEEVSGLLLVGSTVVSISIDATIRQWSLDPTQLEAAKAKAESTAQEDEEVNDIPTSLLTEEEERELAELMGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4Z6</accession>
    <name>A0A179U4Z6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS nicotinic acid transporter Tna1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_09073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03076">
        <property type="protein sequence ID" value="OAT03076"/>
        <property type="gene ID" value="BDCG_09073"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09073"/>
    <dbReference type="OMA" id="TGPQYNW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="86"/>
        </location>
    </feature>
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            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT03076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="385" mass="42943" checksum="B031D17D6BFC8AF0" modified="2016-09-07" version="1">MRPSIWFPLIMVAWGLVMTLMGIVHNYTDLLIARIFLGLAEAGLYPGVAFYITKWYCRHEAQLRQALFFSAASVAGAFSGLLAFAIAKMDGIAGLEGWRWIFILEGILTVVVAVLAFFAIHDYPETAKFLTEEERDWVIHRLRYQYSDNAVDKGKFQWKYVKDALLDWQVYLALITWYGIVCPLYGISFFLPTIIKDLGYTSSTAQLLTIPIYIVAALIAVLSAWLSDRQGQRSRLLFFHLLCIAAGYIVVIAASGRGVPGVVYFGTFVLVSGIYPALPGTVTWLSNNLAGDYKRASGMAIQIGIGNFAGAMASNFYRAQDAPTYYLGHGVELGFAVFGLLAVIVLRVAYQRINKKREALALKHNYTPEELSKMGDRAPTFKYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4Z9</accession>
    <name>A0A179U4Z9_AJEDR</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDCG_09049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03074">
        <property type="protein sequence ID" value="OAT03074"/>
        <property type="gene ID" value="BDCG_09049"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09049"/>
    <dbReference type="OMA" id="HGCNCYS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT03074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="395" mass="44484" checksum="2DED77A4C9ACB00C" modified="2016-09-07" version="1">MLTPFLSLFSFVYSHLLHPIYRTTRRSIMFVFRAEDLPKDPVFPADLKQLGYFINDQDQIKKISNPEEDFVFKINTNDRYNEMQKEAMNTCIRQIVISRLLNLGLETLRLPIGAAANSQHVPILTSPAFQYQPRLIVVFGDPTQDLGIWAYRVISKKGINIGSAVNFATAVNQDQKQSQDNWSNSRTGTGLILTNPGQLVWHCGKEQAISLPMWHALPRRSAVEPPMRMTFRNKIPGNETWQDHITYVFEEVLGKLAAPDVKIDVIGLAEGGLGAVRYLAEHWPTWQSRISSICLTNPLHDTNHLHPPEFATFMSTRSRAYLLSEKPLSTPVAGRYEFGCNCYSAGEALDVESIMPRAWGGMLKWLDVMFENSALEEVEVIVAEDGEGEGDVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U595</accession>
    <name>A0A179U595_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrion protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_05751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01652">
        <property type="protein sequence ID" value="OAT01652"/>
        <property type="gene ID" value="BDCG_05751"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05751"/>
    <dbReference type="OMA" id="VSWERAD"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="204" mass="21805" checksum="0FFD2F84A79A609D" modified="2016-09-07" version="1">MGILLEADYKGIVQGRESVISGLQKLFASSRPGSQNPLQRQEGEELIAKEAGGQLTYELMNRDSAVALAQEASYEHVPTFAFISAAAGAPVVPERYITSKRDAEALVSSNLPGLRSIFIRPTFMYDSSRKLTLPIALGGIVGSEVNALLGGRLSFLGMMTAKPLNVNIVGEAVVEAIGDDDVQGVVGPKKIETLATKGWRRSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U599</accession>
    <name>A0A179U599_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_08936</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT03010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03010">
        <property type="protein sequence ID" value="OAT03010"/>
        <property type="gene ID" value="BDCG_08936"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08936"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="255"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="429"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="469"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="642"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAT03010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="776" mass="86448" checksum="3F8D41A22C5A629C" modified="2016-09-07" version="1">MDPVLKLPPEITSEIFSYLDTSTLLTAALASRAWRERIIDSRLWRHLYIQEGWRFDMDAVRTFEQSLSKPPFSHNRKSRTRRSDTDMGQPKLKKRVPSGWIDSRRGSRVGNNNMQDASPPWSEQHETVEADGTSAFEMNTLPDAEGDHEMRDASYDDHSIGSSPDQSRPPQSIDFSSVQFTHKSGRADSSARYPSFHSPLTNYNPQAKAPHLLRTINGTSRLNWPYLYRQRQKLEDNWRKGRFVNFQLPHPAYPSEAHTECVYTIQFSGKWLVSGSRDKTVRVWNLETRRLRGSPLVAHSKSVLCLQFDPSAEEDIIISGSSDRSVIVWRFSTGEKINELANAHQDSVLNLRFDKRFLVTCSKDKLIKVWNRRELSPMDKDYPSFFNGAGVRYPTYIVDTSLISPSTLEAQIANQQIKTLPPYSLLMTLDGHGAAVNAIQIDENEIVSASGDRLIKVWDIHNGACLKTLIGHKKGIACVQFDSRRIVSGSNDDTVRIYDHASGAEVACLHGHHGLVRTVQAGFGDPPGAEETLRLEAMAVDTQYWKARLRGDIPESSSSVRRQQRSCPVRSSGSRNPNDIMALGAKIPPGGGGSSWARIVSGSYDESIIMWKKDQEGKWVIGQRLRQDEAARAAAANVIPDPALANQPIPPLPGQSPQGLMGPHPMSQSSQQTTPASAAIQSNRPITMGIANDAGSPYLNAMNQHPSQPLQQAQGPLLGANRPLPVPAPHPTARIFKLQFDARQLICASLDHRIVGWDFACGDQELEWACQFFTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5Z9</accession>
    <name>A0A179U5Z9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS drug transporter, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_07922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02637">
        <property type="protein sequence ID" value="OAT02637"/>
        <property type="gene ID" value="BDCG_07922"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07922"/>
    <dbReference type="OMA" id="FRRRGMY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="42"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="518" mass="55662" checksum="06BA41BC834C2129" modified="2016-09-07" version="1">METYVGDEEREGSVDANMESEPFLTPTPSSTPWVAPKGFVWIEVAIFANVFLSGFDGTITASTYAVISSEFNAANNASWLTTSYLITSTAFQPLYGRFSDIFGRRSCFFTSTIAFMLGCLGCALAPDIVFLNLMRAVTGLGGGGLMTMATIINSDMIPFKDRGMYQAVQNVLHGFGSICGASLGGSIADTIGWRWCFLLQVPVSILALIVGHLVVKNQTHYDNSDYETSPKATLSAIWNRVDLSGAFLLIIGLSIQLVGLNLGGNELPWSSPWVILSLVASVLILGLFLYVEATTSAMPVIPLHMLRGKLAVSAQISNICVGLAAYAFLFMLPLFFQVVLKDSASTAGARLIIPSLAAPVGGVISGFVMSRWGQLANLVRLGALLMFIGNALVMLLGFDSAKWKYITYIIPASLGQGIVYPAILFTVLAAFGHSDHAVSASTVYLIRSLGTVWGVAITSAITQNTLKRRLPEALIGIPNKWKVILFSFSSSLFLKPTTLLLSSFSQPHPPVSSFVQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U9A5</accession>
    <name>A0A179U9A5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_09248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03132">
        <property type="protein sequence ID" value="OAT03132"/>
        <property type="gene ID" value="BDCG_09248"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09248"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="DUF2841"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="PTHR36102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="DUF2841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT03132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="462" mass="51876" checksum="667143A5F6BA35EB" modified="2016-09-07" version="1">MHHHKSEIFLPDFENGFIQRASQAIFPGQSNINPASSSKARRPRYLSSLRDMPAQKRQRLAYTVNGASEEEDDDEFEDHPVNKIGLPIGDEERMMAYYAEAFRAFQQINCRQVAKAYIKLIEPRKQAKHPYNGGKAAPGETRDPEKTKPEWWPADVIHKEPDHLRKIPRVKLLIHIFRNLRKSHGITARKLKAAGEEAQKQCRPTEKASVLDEIYRVREEEERYERGEIDADTLIYVVKREKTNRCVREEPETASDSEQPGYIDETSDSRGGHVSEVAGSSRPQNNLQMPPQTLPMHNRVVPTFAETRNTIFSSSISGPFEAGTPNSLSPLGIKPDYEEFTPMGSPASIDTRATLSNVNYFQGLPQSPVDGQYMNPRGSVTGNQAAGNYGAWPVAPVASFQHPGFIQVEYASSNAGMIPQQFMSPMMPSSHASLPIRDLQETRSQQQMGGSPIFHPSFRTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U9D2</accession>
    <name>A0A179U9D2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_09298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03161">
        <property type="protein sequence ID" value="OAT03161"/>
        <property type="gene ID" value="BDCG_09298"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03162">
        <property type="protein sequence ID" value="OAT03162"/>
        <property type="gene ID" value="BDCG_09298"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03163">
        <property type="protein sequence ID" value="OAT03163"/>
        <property type="gene ID" value="BDCG_09298"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03164">
        <property type="protein sequence ID" value="OAT03164"/>
        <property type="gene ID" value="BDCG_09298"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09298"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT03162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="960" mass="105228" checksum="DE3AE146088CC0F3" modified="2016-09-07" version="1">MMTGLKRKLDQTHELGSASAVDSSQVSSTSSSSRARGGNRGGSRSRARGKARAHIGRSKSLNGSSHDEPLPVQSPSDPQTPRAKRVRKAKEEIAHENGIAEANTPRPTRQSARILSKFHHMDSVPEEPDGSAIQQPNFNGPHEIHVGSDDGEVNGNDTASKSPSIRTRKSISDSQLFSFKSTLTDSSRRRRSSGYKTEVETSSPEAVSKPKSKSVDGGAGKRKNTATIPETPTIGSATKRASPVTTRKRNSTSKTTGPAETLNARTKNFKIEMSTSSGNGMQSPSERNGDDKNGDGDTDLPAPETRRTRPVPLLKIRNADSPAQSIELESPLAAREGTPTEVSGSRAATPSETAELSASTLPSVSGRGRGRGGFRGRARGRGWTRGRGRGGRGRGAGRGGRGGRLQPIDREISVSPSPVIKQLRERQKELDRVFRRVASAQRTALTVIANRTEAKLIKDANAHTTVPEYNQVMKALKARLQKRLDVIENEYNWRAKAADALLEANKERVNSNFHDKSRHIREEHLLAAQGSYMAFVEQCRQAEDDDHTETDESGSEADIAPRRRSVRGFNSSFVRDPKGAALYERAAYGWEDFIQRAKIENDISPQIKEITQEARPPVLVSDRISQLTEALTELCQREEDRTSEGKPSNAMPVEPPTALSTLADVAMGDIGQRPAQQPAYGPPLPGPQLAPFRNLPGVTQELPPQPYHPPLQHQPPRLSTDQHSRGLHRTILPQPVLGQMIPPTDPRSFLPPPTQHQPAPPPPPPDSQRGLPNLPRRILPASSRYPSIPHLNELPDPFSSTHPHLPPPPGMAYHPGPYPPHGPPPHVAHGPPPPPPQYMHAPIGHVALGPPYHHAIYGHPPPPPPPLHPGSQHPATHHQHQHQQQLQPHHQPLPLPRPQNAHPYQQQQQQYPQHQPHQPHQPHQHPLPQPQPQPQPQLQLQPQPPQSQSHERTPPPPYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5GFF1</accession>
    <name>C5GFF1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_03104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ER-3</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="EEQ87984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ87984">
        <property type="protein sequence ID" value="EEQ87984"/>
        <property type="gene ID" value="BDCG_03104"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00581">
        <property type="protein sequence ID" value="OAT00581"/>
        <property type="gene ID" value="BDCG_03104"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00582">
        <property type="protein sequence ID" value="OAT00582"/>
        <property type="gene ID" value="BDCG_03104"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03104"/>
    <dbReference type="HOGENOM" id="CLU_2096217_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ87984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="137" mass="15594" checksum="9A7192EDAF5F94B2" modified="2009-07-28" version="1">MVMNKKRGKGKRGERGSLPCTVCVSRHWLLGYELVPLHLRVLLFRSQKNSKKRTGEKKKQERVIQGILQLGQHWTGGNGCWQQQDPGGQKPTSLVYHGVGDPVERYLRKVAWEEQRFTTNRLPSEKIMLARSGGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>C5GFF7</accession>
    <name>C5GFF7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_03150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="EEQ88030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ88030">
        <property type="protein sequence ID" value="EEQ88030"/>
        <property type="gene ID" value="BDCG_03150"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03150"/>
    <dbReference type="HOGENOM" id="CLU_088657_2_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ88030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="141" mass="15470" checksum="907D177BAB57909F" modified="2009-07-28" version="1">MPQAQFSVESAVRRLREFSELTEHRMGLKPREARRAHAAFQLLATGPPSDSKSAGQSIDYFEFLQRVKTLTGNDGIVLCAAGLGPSAIVNMKDAVRVYLPSKLKQEWAGFKIGVLQALAKNYAKGDFHSVTAENKTDLCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C5GFI4</accession>
    <name>C5GFI4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="EEQ88057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002627712.1"/>
    <dbReference type="EnsemblFungi" id="EEQ88057">
        <property type="protein sequence ID" value="EEQ88057"/>
        <property type="gene ID" value="BDCG_03177"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03177"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="OMA" id="WHHGTDK"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="223"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ88057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="364" mass="40263" checksum="40EF53FC867390C4" modified="2009-07-28" version="1">MGDAPSSQEHLVVILPFPEPAALINDIRKSFPHIRVSYFEQQRETQVNGAVPKDLLNSATILCMLHYAPTLEDIPNVKLVHVISAGMDRYLNHPLVTDTNIDLTTTSGIHGPPIAEWVVMNWLVSSKMYDQTSEWQRKHIWTHNQSLINKMEDNVGKRVGILGYGSIGRQVARVAVAMGMQVLAFTVSPRPTPESRRDTGYIVPNTGDPDGSLPISWHSGTDKAALHDFLSQNLDHLLVAVPLTPSTEYLIGAEEMALLSKSCTRTTRRPFLTNISRGKVIDQDALMASLKSGELGGAAIDVTEPEPLPADHPLWDAPNLHITPHISSLGIEYMQRALDVLKVNLGRLEKGEPLINLYRRKAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C5GGK2</accession>
    <name>C5GGK2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_03367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
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                <person name="Cuomo C.A."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
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            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
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    </comment>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
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                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="DUF1752" evidence="2">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="351"/>
        </location>
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            <end position="142"/>
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        <location>
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            <end position="191"/>
        </location>
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            <end position="245"/>
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            <begin position="473"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="502" mass="53999" checksum="AE34584E476E33A2" modified="2009-07-28" version="1">MTEALPKGIVLHSERISSEIESFGGVDAEDLAKLWRVYTTNRSTMKADEGRRLENLFWRIWSNNVILRTIQGTTLAGLFLHISEGESITRMGPGGLREISPSIPRIQSRRRAVPSTSSAQPQKLPTGTSCKSTPNVSRKPSVNATRAPLLPSILKKPRQASNDAQRLPGVSTAGATDRFTGSNTSLSISPTAVFEDPLGESVSEKPRRKKATFASNITSMEPEPVPMRKNISQPPLDPPPARHSPTPASSGETRASPDLYGPSAPRRQIYPIPNESAISISPTPTPNSRPYPWLGPAMQRPGPTSNPTSHPAAAIAANPIHEQHAQQQKRSNSSPTSQPTQPSKVSLVEKDFRSRFVEKRLQESRNPSFTNLGSSLLTQADIKASATTVVSGNPDTVRSRKLQSSGDAGPVMGVQAVRGRGKVKEGRGGHSSAQKQHPSRNNGAGTKAVVVDYVQEEDDEDGEWEDIDSDDDPANSISPSTSQAQPPHQHGVPASSRPSLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C5GK22</accession>
    <name>C5GK22_AJEDR</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
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        <lineage>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
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                <person name="McEwen J.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
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    </feature>
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        <source>
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            <dbReference type="EMBL" id="EEQ90355.1"/>
        </source>
    </evidence>
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    </evidence>
    <sequence length="95" mass="10722" checksum="77E05CAAEDF5FBFE" modified="2009-07-28" version="1">MSAQATSTQSTSQKQPDAAPQTQQQKPAVLEEDDEFEDFPVEDWPQEEAETTGFASGGDTTNHLWEESWDDDDNNEDFSKQLKEELKKVEAGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C5GM30</accession>
    <name>C5GM30_AJEDR</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
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            </authorList>
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            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ89623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="842" mass="92821" checksum="394959D193C242E0" modified="2009-07-28" version="1">MPPDKPLISRAELERDGMVYFEGVFSEDANGDVSLSLPAHVESYRQALLDFSSLGPDRSKPFTPGRFPAPPIQHNPAPLLSMTEDGRRRIDHCAGLSKRARDLAPPYTPDYKWQSLLEEIFKEYKSRFPSGRDQQEKNILWDDTKKYAEKCPKPNFTYGYPIIRDVPIALRSAEPVTNFSFEVLGDLRSAGLISSPVGSLHGWTKDKFTFLSPDKFICFPWAVVEQCRGLFPFEENYAHAANAALVALRLNEELSKFATGSYDSIPPVVAFTCVGSEIRVWLAYSEIKDNLCHVHRMVCIWQHSLSQDRGVLETCVIVENMLLWSSRVWKPKISGYISQIRQCNPALFFPGYSPKPTILSSRINSFEPSVKSTQPKPAEPMFVFGAQRPSSSKANNPDPASCTSIFTSGEQHLSAPKGNDQDPGPGKSPPANLIANTTGGSTKDERRGRKPVVRLPKVKYDETRGSEQKQGNDMQRASRADPATDTIITTEECTTHNTLGNAHSLGLDSVPESAVALEILSERINSLDLDKSVQTAVGIQSTGKGKSSHASNVTEGDTDKESRENPAGGPQAANLEKPSRTTSAIGNSSTAVNSDSRSKQGARTIEKDLNPLTERSENDRPHQPNSALSNDGNSLSAGSSKQDVREGREDFPEYSEGFQDSPDEPELMIGPCPHYGAMVAESLQLLLGDELLRLEAVSKIILELQGHELLDVSWSVLELWVAQHANVPSPCAALDKIIQELNDALGSPDTIVTPEQMWASEPDTWKNIDKALQSILKSSEGTLRNILEWAIESMDLLEGLELCNILKLGELSCLELKRMDQEIIDIMLDSVAPRQALLTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C5GM55</accession>
    <name>C5GM55_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="EEQ89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ89648">
        <property type="protein sequence ID" value="EEQ89648"/>
        <property type="gene ID" value="BDCG_04768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04768"/>
    <dbReference type="HOGENOM" id="CLU_868685_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ89648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="259" mass="28806" checksum="152DB540CD047AC5" modified="2009-07-28" version="1">MSLFGQPGIPLLGEHLELMQQDDSTFLELALDPDVLSSECRTDTFHTESSSKSVTPAFFEQKSYSSPADDVNASPVTPWNSSPTQIYPPATNSDTQELYDALNFSEWCHDITNYASPCPDPLGETSWGQGVLDTGPLGSLSRFMPSSPSRIRSSVPLPSFDKDSPPDLSQIDFEKLIDSHELLPDLTLTPGASHQAEQNFENKRERSDSCLANPTFKPPRKKKPVLVREYNLRKLPSRMLKDPAIQDKGSKNIRRHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>C5GNW0</accession>
    <name>C5GNW0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">von Willebrand RING finger domain-containing protein, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">von Willebrand RING finger domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05761</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ER-3</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="EEQ90641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ90641">
        <property type="protein sequence ID" value="EEQ90641"/>
        <property type="gene ID" value="BDCG_05761"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01657">
        <property type="protein sequence ID" value="OAT01657"/>
        <property type="gene ID" value="BDCG_05761"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05761"/>
    <dbReference type="eggNOG" id="ENOG502QTWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006368_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="494"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ90641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT01657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113223" checksum="26FEE4C5747B8A25" modified="2009-07-28" version="1">MAGMMDVERTRPRRERTFVGSECAVCEEPLEHTLRGERILQLSCGHVSHEACFYEYIKEFESQYCPTCSAPLGLDSNRGGNVLDLAKLSNIVRSVSVSDVSSRRGNQNTPTPWDINGNRAHEDDMGSLHCSRDSRRRHSRDTSNQRERVERLTSPSTRQPHSRSDSGTTGVASSGDYGDGQHHSTGRRHDYDVQAMESDLSPRPGVIRNPIPAPIVTVRSEFPTLNRSRQQQSLTCLVTVEVPEGNWHPDLEDLRHTAHIPPPRNEEIVSPPIKQPARPLPVPYEAQEALQEISEELRMRVDNWHGLEFQRFGKLKLHGTVRVGKDRTSWQELECYLFAEMLICVKEKKNGHSQFEDPRTKRKMTRCTLKGSILIKKHLKDVESVPEEPILTLNLSVAELPCFHLQFQSRNQLELWRRGLLDLHNPDSAGGRNPDYDVDTSGTEEDDYRTHKTIKRVSSTTSSYGASKSNNTALTDYTNSIRDTLPPSFHVPLDLVIVIPVSSSMQGLKITLLRDALKFLVQNLGPRDRMGLVTFGSSGGGVPLVGMTTKAWSGWGTILNSIRPVGQKSLRADVVEGANVAMDLLMQRKSNNPLSTILLISDSSISEPESVDFVVSRAEAAKVGIHSFGLGLTHKPDTMIELSTRTKASYTYVKDWMMLRECVAGCLGSLQTTSHQNAKLKLRLPEGSPAKFVKISGALQTTKRAAGRDAEAALGDLRFGDKRDILVQLVIIPDNTTQEHVPQDAWESIVSGLEALGGPLDGDEQRIVSVEEVPLIQADLTYGDILREGHLAHCPRPSLLAITMLPASQRPKSGRPSTPPIPPHPSIVQRRMELLTSDMLTRALTLVSRSQQDRAHHLLTETRSILKGLGKGGLPPLPPFAQKPTQDAASALSSPNSSSPEIPETTNTTHASTPPAIPHSPHPPSNPPSETATITPPVNAVDSSIIAALDADIEAALEWINHPAVFGRDSRKAVLQAIGIISSQRAYTFRTLSEAHWAERVAGIKRLTERSREWREIGDDSLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C5GNY0</accession>
    <name>C5GNY0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="EEQ90661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ90661">
        <property type="protein sequence ID" value="EEQ90661"/>
        <property type="gene ID" value="BDCG_05781"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05781"/>
    <dbReference type="HOGENOM" id="CLU_021768_0_0_1"/>
    <dbReference type="OMA" id="TEAINLW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="90"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ90661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="299" mass="34402" checksum="78933600E4821D81" modified="2009-07-28" version="1">MPIKQQIQLSATLNAMQTEMDFLDSSFFTKAGHKSLPTAAEVGSLSEQFNKHPRPAPVKFEHLNLLVKFGPSVAVEEALTLRMLRMSFTEKIPVPEVYGWRVYQNSVFIYMELIQGDTLHDRWDSLNELDRNFICGQLREIISSLRQIEPDPCDSFIGSINRACLHDYVFATIPQSGPFKNVKAFNDWFSSLPQSWLPDSKRYRDPYQDYLPDNGAIRLTHGDLHRGNILISPAGHPRVLAVVDWAHAGWYPEYWEYCKALYTSDYKGEWRNVWIPKFLTAYEPEFAAFGEYVLQIGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C5GTA5</accession>
    <name>C5GTA5_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosidase</fullName>
            <ecNumber evidence="2">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_07646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="2"/>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="EEQ92526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626165.1"/>
    <dbReference type="EnsemblFungi" id="EEQ92526">
        <property type="protein sequence ID" value="EEQ92526"/>
        <property type="gene ID" value="BDCG_07646"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07646"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027506_2_0_1"/>
    <dbReference type="OMA" id="QIVWQID"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="Glyco_hydro_16_CRH1_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002950702" description="Glycosidase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="33"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ92526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="402" mass="41328" checksum="E8B070571B1E2925" modified="2009-07-28" version="1">MKLSSGSVAALAMSLFSGSSLVAAQTWTACNPMQKTCPPNPALGGTADFEFHTASARFDILGGSPSYGADGASLAVAKQGDSPTLISKFYIMFGHVEFVIKAASGRGIVSSAVLQSDTLDEVDWEWLGVDNGRVQTNYFGKNQQGTFDRGQFHSNPGNQNGYHTYSIDWDSQRILWQIDGSTVRTLTAAEAGASYPQTPMQVKAGVWAGGDPTNPPGTIEWAGGPTDYSAGPYVMGLKSIAVTDYSTGTEYRYTDTSGNWGSIEAVGGKVNGRGTPGSGQQVESSIPPAEATRPPPTKGLPSDWIVTDSGRASTPSTASRTSQPTSQSSPSSSASSSARGPESSPSITATGFVTSPTVTPSPSATDSAGATVAPGTGAANGNFHMSYGVAAMCALIGAVVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C5GUD0</accession>
    <name>C5GUD0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="EEQ84588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ84588">
        <property type="protein sequence ID" value="EEQ84588"/>
        <property type="gene ID" value="BDCG_07857"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07857"/>
    <dbReference type="eggNOG" id="ENOG502TFKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056039_0_0_1"/>
    <dbReference type="OMA" id="RNISHSW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ84588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="456" mass="50442" checksum="49CE33A1764B1D7D" modified="2009-07-28" version="1">MIRRLSTLISPKRAPHRPRENVEDKTKYYDIDNAVASSRPRSPLTDRQCLSLAAETQLQNACLFLSQKIEFPDRWTEFDDTCADQMDVSPTGSHFPDLKISSFTIPDHIASAVNDDPASGSDHLSNEHESGALDPEDKVCLDLKEKQVLTHDYFVDAFELEQSTAPLVVEEVGKISSSIDELKFPSHFTREHNPLPETFINSLEEDWKDLRSAKPPYDAGLHSILPQFVNRESHATSSSRERNISPHQQQIEINSQLGGSDGPASPALENNNPLHTDLKCQTEKTPAKPIFKINTNLSPMLDDSTERDLSISPLSYAQSWTSRSTTGKTIIDANGLEKVLTPVEEQQRRLGLQRAVMEKMSGGFSVPTSPDTNRATAAIHSNPPPPIQPTPPTSPAWNMANAKEQSATSKPVDANKLDEQTKNTLVRKLSLLTLGKKKSVAKINNVLGFSAIVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C5GVE4</accession>
    <name>C5GVE4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolin, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="EEQ85305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ85305">
        <property type="protein sequence ID" value="EEQ85305"/>
        <property type="gene ID" value="BDCG_08574"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08574"/>
    <dbReference type="HOGENOM" id="CLU_026791_2_0_1"/>
    <dbReference type="OMA" id="GYVQYSS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12448">
        <property type="entry name" value="RRM2_gar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034276">
        <property type="entry name" value="Gar2_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="261"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="365"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ85305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="512" mass="53013" checksum="5224BA917CF3A9DC" modified="2009-07-28" version="1">MSKTKSTTKASKGGDKAVSKVKSGSVTKAAVSAKSKGKEVSKKAVKEDKKKKKAPTPSESESESEASDSSEASISESDSSSESESEAEMKPAAAKAAVKPAKAAKAAKAESESESESDSESESDSESEGSSSSEDEKPATNGAKVETSESDESESESDSDSDSDSDSDSEDSTIEEKKPAAKAVAKESTTEESDAESGEESSEGSEGSSSDESSDESAEESEEAESAEAEKPSSKLQKRKAEDDEELAAPKKTKVESSEGGNLFVGNLSWNVDEEWLRSEFEEFGELSGVRIVTDRDSGRSRGFGYVEFVNAADAAKAHAAKKDVELDGRKLNIDFANARSNAAPRERAQSRAQNFGDQASPESDTLFIGNISFSADENMISEAFSEHGSILGVRLPTDPESGRPKGFGYVQFSSVDEARSAFQTLNGADLGGRPMRLDFSTPRQNSGGGGGFGGRGGGRGGGRGGPRGGGGFGGGRGGGRGGGRGAPRGGRGGSTNRGGFGDYSGKKTTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>C5GVH9</accession>
    <name>C5GVH9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bis(5'-nucleosidyl)-tetraphosphatase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="EEQ85121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002629047.1"/>
    <dbReference type="EnsemblFungi" id="EEQ85121">
        <property type="protein sequence ID" value="EEQ85121"/>
        <property type="gene ID" value="BDCG_08390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08390"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ85121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="137" mass="15126" checksum="81AF4B33447365B5" modified="2009-07-28" version="1">MSAASAACLFCRIVKGEIPSFKLYESERVLAFLDIMPLSRGHALVIPKFHGVKLTDIPDQDLAELLPVAKKLAIASGAVDFNILQNNGRPAHQFVDHVHIHMIPKPNEKEGLTVGWPNAEADKEELKALCEEMKAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C5GWH8</accession>
    <name>C5GWH8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2 family protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_08804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="EEQ85535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622401.1"/>
    <dbReference type="EnsemblFungi" id="EEQ85535">
        <property type="protein sequence ID" value="EEQ85535"/>
        <property type="gene ID" value="BDCG_08804"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08804"/>
    <dbReference type="eggNOG" id="KOG2151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032319_1_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="PTHR23326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2_3_5" evidence="5">
        <location>
            <begin position="397"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ85535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="530" mass="57797" checksum="E0338F0B0CBCBB76" modified="2009-07-28" version="1">MSGFPAQQQQQPQTRPTNPSLVSTRLPNGKIGTAANWGFGLPMGGAPGLQSNQQRTVNAMNSFAQSISGSQPATPLDLSEFPSLSSVPQQSQPSASGQVTWANASQRVNQQSAIQRQSQTPATSQPPSRVSQTQALSHQPPSQSHASHEDLFPSATQFAAQLDDFRNGGQGISGQLSGGTQPQTGNIDEFPPLGRNGPADIGQERRASLLQSGAFGNYGGGMAFPNLNQSHSGQGRTLLGNMVNGQQDGRIMSPGAGGSGVMSTSRSPMGQVQNGGLSQEKDDLGASSMQRTIRPEAYPEQQSQPIMQQPPQNRQQKSGNFGDEGQEQSQQGQSSEQAPLTQLSDRDRFGLQGLLSMIRSENPDVATLAVGQDLMTLGLDLNQPEPLHPSFASPFISSNAAVPLQVDFTLPACYNVANVQPLQTRIPSFSDETLFYIFYSMPRDVMQELVAEELMSRKWRYHKVERAWLTRDEAYIVEMERGLSERGIYIFWDTTTWKKIRREFVLRYADLDNHLDRRGYAQGVAFPQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TTU4</accession>
    <name>A0A179TTU4_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_00026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A179TTU4"/>
    <dbReference type="EnsemblFungi" id="OAS99264">
        <property type="protein sequence ID" value="OAS99264"/>
        <property type="gene ID" value="BDCG_00026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00026"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="615"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="765"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="685"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAS99264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="935" mass="103285" checksum="2DE46B286686A376" modified="2016-09-07" version="1">MNPSRSSLSAHSLRSSQRRFSIHPPNINSPTDTIPQHAHTPTTETPREGGAHTIPSPLRDEIYEINEIKRYEDFTTIDWVQDAVHEQARRRAKRIDASRFWDQEGTLGWRRKVRESYDAGQAWLVITIVGAAIGFNAAFLNIVTEWLADIKLGYCTTGFYLNESFCCWGADDGCPEWRAWTPIAPLNYIAYFIFAVLFAFSSAVLVNSFAPYAAGSGISEIKVIIAGFIMKGFLGARTLIIKSLTLPLSIASGLSVGKEGPSVHFAVCTGNVISRWFGKYKRNAAKTREILTATAGAGVAVAFGSPIGGVLFSLEEMASYFPLKTLWRSYFCALVATGVLAAMNPFRTGQLVMFQVKYDRTWHSFELIFFVLLGVFGGLYGVFVMKWNLRSQAFRKKYLSRHPIIEATVLAGVTALICYPNMFLRINMTEMMEILFRECEGAHDYNGICNTNNRWSMVISLAIATIVRVLLVIVSYGCKVPAGIFVPSMAIGASFGRMVGILVQALYEAFPDSKFFAACEPDVPCITPGTYAFLGAGAALSGIMHLTVSVTVIMFELTGALTYILPTMIVVGVTKAVSDSFGKGGIADRMIWFNGFPFLDNKEDHIFNVPVSHAMTSKPVVLPATDFPVSKAENLLQQHKYQGFPIVEDLTNKVVIGFIGRTELQYAINRAKREGLLSPNAKCRFTSTPSASSHRNRNTVQPTSSLTLQIPSNRQTFGSNSSSSSRSEDHPFNSDHSPDDRPPSRTFDDIATSAGIRSIDFSQYVDLAPLTVHPRLPLETVMEIFKKMGPRVILVEHRGRLSGLVTVKDCLKYQFKVEAQEHTASGVGVGDDGHGHGHGSNSGLGEGIVEQKAWELIQWATEKVAFWRRMGWGRGRGRGGLLRLGSSQEERDWRRGSGHEANEWDGELLQSRTSSDIVDGTEELEGFVELEERGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUW9</accession>
    <name>A0A179TUW9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="8">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_01029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="8"/>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99673">
        <property type="protein sequence ID" value="OAS99673"/>
        <property type="gene ID" value="BDCG_01029"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01029"/>
    <dbReference type="OMA" id="CLHYYVH"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Put_53exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="PTHR12341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="734"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="813"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAS99673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="921" mass="103585" checksum="08BD26241F89DC52" modified="2016-09-07" version="1">MNQQRSRRFRSAQEAKEADEKKEEFAKLLRKQNGNKGGEGLVEEVITKTWDSNVITPGTPFMDILAAALRYWVAYKLNTDPAWEKLKIIISDATVPGEGEHKIMEFIRSQRSCTEHDPNTRHVIYGLDADLIMLGLATHEPHFRVLREDVFFQESKGRTCHLCGQPGHIAEACKGLAKEKNGEFDEKGKGSPLKPFIWLHVSVLREYLAVEMHVPQQPFPFDLERALDDWVFMCFFVGNDFLPHLPSLDIRENGIDTLIAIWRDNIPVMGGYLTKDGHVDLDRAQLILQGLAKQEDAIFRRRRQTEERKNANAKRRKEEERFREEERSRKKRRSSPSYGSMENEPVPPPLIVPGKGHISRADRELTHAMVVNRGAVYKANMANKSAAAVLKSQLVKGSGDAATPDVEDSADGRAKNTSPLSLGKRKADALETETESETPKKPQDNDELPPDTVRLWEDGYADRYYEQKFRVDPKDTEFRHKVARAYVEGLAWVLLYYFQGCPSWTWYYPYHYAPFAADFVDLGKMNIEFSRGAPFKPFEQLMGVLPAASNHAIPEVFHDLMSDPESEIIDFYPEEFPIDLNGKKFAWQGVALLPFIDEKRLLLAMEKRYPLLSSEEHARNTMGREVLFLSDRHPLYDNLTANFYSKKQGTPILKLNMRVSEGLGGKVERNDAYVPHSSLVPPFDKVDLPTLDEDHSISVIYDMPKSMYTHKSMLLRGVKPDPPVLDKSDIEITRNKAQRSGRSFGGVPFGNNRGRGGRMSYASDRPSNDRPNPFAAHINPNFVPPPIPPPHMGGPPAGWAPPPPGMTGSSYGTPRFDKPQQGPPYQQQGSRGYSHQSSQRGQYSQSYSQPREYGQGRQDVQSQQYGQRGGGGYGQHSGGNGSSGGGGGGRGRGGGPYRGGGRGHYQGQNGYNNRNDGYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUX4</accession>
    <name>A0A179TUX4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_00128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99309">
        <property type="protein sequence ID" value="OAS99309"/>
        <property type="gene ID" value="BDCG_00128"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00128"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAS99309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="446" mass="51736" checksum="8BBFFB48F9EDEA07" modified="2016-09-07" version="1">MECRRYGYRPSRRWIYLATLVFSVLGGGYLFLRTHGATHYQELKLIAPFNFLFPSPPEHAECPSIRGLDDIHVILKTGATEALAKLPVHPNTTLRCIPHFTIFSDYEEEISGLHIYDVLRGVNDTMKNTRPEFKLYTSLQESGREVLSTWNVTDDESTPRGKPNNPGWVLDKWKFLPMMHETLQVRADANWYVFMEADTYIIWPNLLAWLRQFDADKPYYLGCPVQLYNNVFAHGGSGFVLSRAALKRVTEFHSTRVEEWDEFTAREWAGDYVLGKALMDGGIGLHWSWPMLQGSTPWSLDYMSKRYDNFPWCYPPVTYHHMTPDDIRAIWDFERNWRRGNGNTLVLHRDVFQQLVQPGFRKREQDLDNESPDIVENVGNEKDCAQRCVDDVKCFQYSYEPGNCRTSKLAKVGVRKPGVVSGWMVERINQATKSLGSCEEIKWIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUX8</accession>
    <name>A0A179TUX8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_00831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99584">
        <property type="protein sequence ID" value="OAS99584"/>
        <property type="gene ID" value="BDCG_00831"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00831"/>
    <dbReference type="OMA" id="KYARLIC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="607" mass="68206" checksum="C1049303DA137A83" modified="2016-09-07" version="1">MQDQRGERRPRGKYSRLICRGCRSRKIKCILPNPTIPHSTSPRDARRLLDLISHDMASSLDACLVWHRFFLPQTPTLVSIRNRLSSDECASSNCATNLLFALLCLIAFESPETPFGQKHHHLKRSIQLTVSSYGQEFIFSPPTHRDSVVVSLLLSDYRPAAIVSSPNVAHKAVKSGLYVNIAYRIAEKLELLPTQATLNPGELKAVEFFGSEFCLTDVLQGLQVFCYDALLDGFITKPLRFMRKVVSCIKPHMEVYQNVLKHRSYPPWIIYHIQNTVATNIMLEALVDMKQSWSSLESLSIITEDCERKCLEQVEHTDCLLARLSSPGNQNELLVVRSLLEIRFHSVYTAIYGAGLFYATVLRARLQESGRVGTDPEINCHEAAQLGAQLIDTCKNISSEKVLTLSAFMGRFGGPYPEKLGAILEMFIECAEKLALNRIAFCPPPRQFVLEIVFLCKNIVENNVIQFKSFGRLHKDFERQLGLFEKCARRIESMVVSDWNSIDAAFAGGCVYAASSKIIHGLCEVMENLKIRVSKETSGTEKPSMLEVPTDLSGLDVEVPSGGWDVWPEVGGFENFGTLQGQFDWSFIQSSLLEFESTNTSFGDRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUY6</accession>
    <name>A0A179TUY6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_01072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99695">
        <property type="protein sequence ID" value="OAS99695"/>
        <property type="gene ID" value="BDCG_01072"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01072"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="71" mass="8312" checksum="8686174512BFBB6E" modified="2016-09-07" version="1">MSRATVHLSIPGDWKLWYKHMLEYAKNKKISDFINLDKPDIFSELEEPLKPECSEEAITETKIVYNIKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUZ6</accession>
    <name>A0A179TUZ6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_16273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99703">
        <property type="protein sequence ID" value="OAS99703"/>
        <property type="gene ID" value="BDCG_16273"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16273"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="107" mass="11704" checksum="23AA60712A5E8934" modified="2016-09-07" version="1">MHIGHEAGNFCYIPFAAGQKLEHILADNSSLQPHAPSSLLVGVGVDQVPGIRCTCVIWLNQITRMNATVEALSLGAFADLSGYCIRALTRVARCTKYVAYTWLNILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVG5</accession>
    <name>A0A179TVG5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_16369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99883">
        <property type="protein sequence ID" value="OAS99883"/>
        <property type="gene ID" value="BDCG_16369"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16369"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="115" mass="13197" checksum="8D1B11D39BE14FD9" modified="2016-09-07" version="1">MLELQQQQIADMHATQQLQYEEIQQLTHAIPTSTESNTKALKEHLGAPAYFNASDLTLYSSWRMEMLAKLSVDEDSISSLTNQVLRTSDNIMRHLDILFQDTAMQQKALDWLQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXK2</accession>
    <name>A0A179TXK2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDCG_00787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG11 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99576">
        <property type="protein sequence ID" value="OAS99576"/>
        <property type="gene ID" value="BDCG_00787"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00787"/>
    <dbReference type="OMA" id="GLRWYLI"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="PTHR13222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="3 6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="ATG17_like" evidence="9">
        <location>
            <begin position="97"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ATG11" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1230"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="818"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1238"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAS99576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1310" mass="147396" checksum="AB1FE84A665D2A33" modified="2016-09-07" version="1">MSLHIYIAHTGEQLLADPVSFASPDALRTWISRKVSIPAQRQILMTARGRNVRPQTLATENEIFVYDRLYISDGTVRDLREIAPPERFIPENPPDTLADQNNLQAWRNLYMARRAWALNLAAQCAPISRATDNQIEHTHVINRAVDVALENLKSHVGNLEHKFQEAQSWANDLLKEQQLALDSWRSVLTNIEATPANKDFTFLRRPSTPKKAKERQTGTLQDYIDVDRVKSAASQVSTVSQRFACRMDEIEKAVHEVASETESLVEASHPSPQENASSLLEEIETIAKKISSDYEHVLALPNTQKTLSSVSRMALNHTKDLLPSMLEMGLEIQTALEHSIKQRNLAMKAAVSRMQKISKIESRLAGIQTELSNLDVEGDAFETLYKASQLPLLYGSVLIEAVRRREWSDKMKNDSLSIAEELAVFRDEEQRRRKKWIKNIGSFVSLPEDATPGIEINLQGGQQPEWPEVSRKEVEAYIEELKTKPDTNSAVQELTQLLKDLDAPTRQQRRKAKAFKHGSVFDIGRSSFLNRGDDMVRSLKDEKTKLEDRLKGSESRIRKLEDLLHRQSQMSRPVSANFGSDIPISPASPRPDTLSRRSSVSSRRMSSNQTPEDKALVQRIVSLEAELVAEKENVSRLQKEAHLDRQSSSDKIQEAQSTKKDLMENLEAQQREFEDERRFLESEAKSIKIKLEETEEELDRVMDAREHEKLVADEQITALQTELDNLRNDTSKEIATLTTQVQAFREASEKANAQNTSLKAKLEEVDRTQRDYVNALQTTHAHLSPGGSAPGGLSSLIRAIEVLSEGLAIHSKGADEAFAKASEENKCLLEKVERMEAETDGLRARLAAEESERSKLRKMLSEETIKLSAVRTELEDERKQLSTLRSKFSAGETGSEALKERVAEEERKVATLTEKLAVEESRAQGFEDDIRTWQKKVEMLETTGERNDSLLSIKESWVKELSEKLFSHVEQLNRILQQLGFTVIRQDNSMVIHRASKVNNNSSLLGESVKSPLATPMIHDPKLLERVNTNDREEEQSNYTAFITAINEFSVELFGEAVVKRVKDIETLARKWQKEARGYREKSHRFQSESHEKIAYRSFKEGDLALFLPTRNQAIRSWAAFNVGAPHYFLREQEVHKLHTRDWLLARISKIEEKVVDLSKSMNGTNPDRRSIGEASDGASIDDDNPFELSDGLRWYLLDASEEKPGAPSTPGLAKSTVASAHVDAKGSIRLKRPTNGGGATKTLTKSLDSRRNSSASKIGTPVPTLQAAEPAGDNVLPAAGDSGAQERRAEAPIFDEVRRDLLLGPSNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXK9</accession>
    <name>A0A179TXK9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiq_cyt_C_chap domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_00276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99370">
        <property type="protein sequence ID" value="OAS99370"/>
        <property type="gene ID" value="BDCG_00276"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00276"/>
    <dbReference type="OMA" id="IDHFFFE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="PTHR12184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiq_cyt_C_chap" evidence="3">
        <location>
            <begin position="136"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="317" mass="35116" checksum="5725E8E032F4A129" modified="2016-09-07" version="1">MLRFTFKPQRHCALNSCSTSLPRRAGTASSRYVSTSTSTSTPPPTKNSSRTILRDPKNEPANTPSSPISHIAQSLQSRASRTTETYTAYGATKKMFEACQLQADYKIPQASQAGGIVPKTANGEDLGVGEGAWYKELGLLPTFSTWSQITFLHMYLLTVRLRTLPSPESFRTYSQHLLDNFSHNAEHRMTIYHGMTMRGIRNRYLKDLFIQWRGVLAAYDQGLVSGDAVLGAAVWRNIWKASHVEPKAADDGNAPGEMDWRKVAVVVGYMRRVLAEMGRAPDEGLVDLVIGKKAFGLNRQDWGLVGTVSRGMNEPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXL1</accession>
    <name>A0A179TXL1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pal1 cell morphology protein, variant 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Pal1 cell morphology protein, variant 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Pal1 cell morphology protein, variant 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00834</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ER-3</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99585">
        <property type="protein sequence ID" value="OAS99585"/>
        <property type="gene ID" value="BDCG_00834"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99586">
        <property type="protein sequence ID" value="OAS99586"/>
        <property type="gene ID" value="BDCG_00834"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99587">
        <property type="protein sequence ID" value="OAS99587"/>
        <property type="gene ID" value="BDCG_00834"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00834"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PTHR28307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="524" mass="57333" checksum="BE2F05F55E1BB83D" modified="2016-09-07" version="1">MSLAPISVPDRQPSPRLTVNLGSNNPFRNRASSPSIASPTTSIPRQRPVSRNPFLDDSESFTPLPDPNRNMSPERLSTVDPPLTGHAAELFENLSLDTPVDKPSSSKGRRPALPRPENVPPSRPSLSDDKASSRRPARRPSKEESQSRSKGHGRPPIGDIFADPKEPSKSRNQRRPRRNSDSSLMDIPSRPIDPEAERRRRERRQRERDAKPKDGKSRSKRSNGHRLDIIDKLDVSSIYVFHHDGPFDACNPHRNRKGSRAAPMQAFAKDSRNMALGGAGPNNTNIDLNLFHGRGEEGYADYASSGLTSSKINQSAAFDPTAKLEPIHGAESMGLGTSTFLEGAPASRAAIQRRESENEAHNLQNGGLQRKKSLAQKIRGINNRVPRVTSPPDSAIDSNNYFTQASPPRASGSRRPNDKNPFFQQQDYDDAYDKKGAKIQLSDDGMTDNLLPHTRQRSTSSPKAIPGETRITEGRSSSIGGGEDAKTHAHTASGSGGFINRVKSLRRPPQPKRRGTTTAAGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXL8</accession>
    <name>A0A179TXL8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00606">
        <property type="protein sequence ID" value="OAT00606"/>
        <property type="gene ID" value="BDCG_03150"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03150"/>
    <dbReference type="OMA" id="QWHESTS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="166" mass="18151" checksum="12519110650F5CF5" modified="2016-09-07" version="1">MPQAQFSVESAVRRLREFSELTEHRMGLKPREARRAHAAFQLLATGPPSDSKSAGQSIDYFEFLQRVKTLTGNDGIVLCAAGLGPSAIVNMKDAVRVYLPSKLKQEWAGFKIGVLQALAKNYAKATKQVYGGVDEDSRILPPIEPQITGTANFTSGPEERGKSPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXL9</accession>
    <name>A0A179TXL9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00664">
        <property type="protein sequence ID" value="OAT00664"/>
        <property type="gene ID" value="BDCG_03324"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03324"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="125" mass="13893" checksum="B1B8E69BEB69DDD8" modified="2016-09-07" version="1">MSRQMSRQRGSGATEEGGRGARQTRGEWKREERRLGGEERGERREPQWDGGYRGGGTWPADFCGGGTCWYLPPGASSLAGGYQPPSKPALGKAWEDAATRNRQPPMRYLRTEASSFPYAAFRYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYA6</accession>
    <name>A0A179TYA6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00018">
        <property type="protein sequence ID" value="OAT00018"/>
        <property type="gene ID" value="BDCG_01780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01780"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="668" mass="75630" checksum="89AB076619AD7272" modified="2016-09-07" version="1">MAKLPGVVYDFKFSNLIEPSRISPACFHSTLPVRVSRFVGQFQAASLDAWREWTEALEADQEDSQLRALYLTDSGDNFMSLLLPECPPELITPWTKFAQFGLCWHDAAKNLDEQSRNSALTDLLQNLDQKNQNFQFKINELWFDAFKDFTGTVGITDPCTHFSKLFKNIVTTKRTADLTVEMNFEEYKLLRGDYGEERLIISLVASYARISEEEQNSISSFVDKGILALALLNDLYDYQKAFRNDSKGATLDRISNTVVFLMSTYSRSEDDAVRILKTEICALEDAALHEYDTWQLSAVQRSDELQFYAALIMAAAGGMAYWKATFETDPATSANDGDIPTASKLSGNKAQISVTAEIDVFQTFRRAPSETMCMAPFEYTISSPSKGNLSRLVEGLRAWIPGLREESVKVIETAAMMVYHNLLMVDDVQDGSQTRRGMPAAYILYGTNQTMNSATYVWVKIFELMAQLKFADACRDILIDELKSLGLGQSLELHWRFHKLCPPISDYFVMVDNKSGSFFQLVMRLMSAESGNPAAPDTKLSHFINLLGRYYQIWNDYQNLESSEYMAMKGFCDDLSEGKLSIILIHTLQNSVAKDRIKGLMFHREPGIELSDELKSYILSEMKAAGSLDFTKHVALQLYDAMLETLTELEATMGENKLLRYILHAWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYB5</accession>
    <name>A0A179TYB5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anion exchange family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_00888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99610">
        <property type="protein sequence ID" value="OAS99610"/>
        <property type="gene ID" value="BDCG_00888"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00888"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:inorganic anion exchanger activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="PTHR11453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="HCO3_cotransp" evidence="7">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HCO3_cotransp" evidence="7">
        <location>
            <begin position="123"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="514"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAS99610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="514" mass="56568" checksum="BAB4D64790F23B62" modified="2016-09-07" version="1">MFEQTDMSYGVNEVLLASVLGAVVFALLAGQPLVIVGVTGPITVFNYTVYDIMSPTGTNYLGFMCWIGIWAMIMHWILAITNSCNALTYVTRFSCDIFGFYVAFIYLQKGIQVLTRQWRKSGEASAYLSIMVSLLVLMCAYICGAVGESNFFQRYIRKFIEDYGTPLTIVFFTGFVHIGHMKNVPIETLPTTKAFFPTLDRSWLVNFWDMDVGDIFLAIPFAVLLTILFYFDHNVSSLIAQGTEFPLRKPAGFHWDIFLLGLTTGVAGILGIPFPNGLIPQAPFHTAALCVTRQVADEDETNKGKTVRVIDHVVEQRFSNLAQGLLTLGTMSGPLLVVLHLIPQGVMAGLFFIMGVQALLGNGVTQKLKFLAQDRKFTPASDPLKRVERKLAIWAFVGIELVGFGATFAITQTIAAIGFPVFILILIPVRTFLLPRWFTQAELAALDAPTASPFTMENVGGTHGYGDSDVTVTPASEQGGGLFKSSDSTVEDELERGESYALQARSAMRRGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYB6</accession>
    <name>A0A179TYB6_AJEDR</name>
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        <submittedName>
            <fullName evidence="3">CAMK/CAMK1/CAMK1-RCK protein kinase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00049">
        <property type="protein sequence ID" value="OAT00049"/>
        <property type="gene ID" value="BDCG_01839"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01839"/>
    <dbReference type="OMA" id="MAAIQNF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="379"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="457" mass="51160" checksum="C0972256A0A06318" modified="2016-09-07" version="1">MRQIDHPNIVKLIEFSESRQFYYIVLELCPGGELFHQIVRLTYFSEDLSRHVILQVAKAIEYLHEHCGVVHRDIKPENLLFYPVPFIPTKNPKPPAPGDEEKADEGEFTPGVGGGGIGQIKVADFGLSKVIWDSETMTPCGTVGYTAPEIVKDERYSKSVDMWALGCVLYTLLCGFPPFYDESIQVLTEKVARGQYTFLSPWWDDISKPAQDLVSHLLTVDPEKRFTIKEFLQHPWIKQTNEETHAAADAPPLATPSALHAQFLETPAAVMDRKMDFRSPGAINLREVFDVSYAVHRQEEEGKRRNNFKQGFHAPLNPLNEDFDDDNSDNDEDLEGIIYYDQDKHAANPAKVTPRAGHNPTEVATMEAKLKSTNLNATAATQPSAAAQARQREQQQQRQRQAPRQQGGGGYGTHSSTVAAAARENAARSARQPFELSLDNATLLGRRGRRLQGQKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZA3</accession>
    <name>A0A179TZA3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FarB protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99960">
        <property type="protein sequence ID" value="OAS99960"/>
        <property type="gene ID" value="BDCG_01652"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01652"/>
    <dbReference type="eggNOG" id="ENOG502SI3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="Transcription_factor_dom_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal_trans" evidence="3">
        <location>
            <begin position="113"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="798" mass="90637" checksum="0754A783D34D19FB" modified="2016-09-07" version="1">MVSRMGPMESILARPTFPQYIDPPRQPPFFGGMWGEQETQFEMLRSMNSHLPRTILPFSLDSPNGDSNVIFSFYRFIELRDLHTLPTEDVKFLEMKGCLHVPSGPILDEFVRQYFLHVHPCLPVLNEADFWSMYANRNDGIKKPRAISLFIVQAMFFASCAFVPPSVIKSAGFVDSRIARNTLYRRAKLLFDLNAENDVLAKAQGAILLTYQSSSIDFHAGSLWLTTAIQHAILYGAHSYNSKSNVTDPHRGTKKRLWWSILLRDRILPLGLRRYPQITPQHFDLSLDCMAEEDLQDEIHKSEVYNAETKRILANVLRVQCQLAIVLTRVIMIVYAPNGFSQPKSMTEKEFMKSLREIEDIRATLTQWANEAKAAFGSIFASDDVHESVTLYSNLTFMYYHTARVALCHNQALTIEIHQRFIAETYSKLLEGLKDELEDAALSITRSVKRLLMRGVARHLPISAIAYTALPLVLNALDVKLSGTTSQSATRKRRWSYYAEVMQLYRNRYDGTDYVALLIQEVLRFAEKQNLLISFQPDESSSIMSSPNSSRDNGKEDTNKSSPVTETSNGPAASNKRTKSWSEVFIRQPRFYLRLSLSIDFAFARGQYPRDTDLPALVRELHLRKDSDQAIETMQPNIPVEVRLKSLPPLTKSQPQPPNQQEQEQEPQQPGDQFTVQDADVYYGVDGMTEVPNPEQQQEQQPQQSHQILVSHPPPADHNLAPQLTTDQLLFNNSVNLREVNLDFLDLESPLLDSLNGGVELGVRADDSGEDGDFTFGKVGSSYWVDGILEEIITRVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZA4</accession>
    <name>A0A179TZA4_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_03565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00783">
        <property type="protein sequence ID" value="OAT00783"/>
        <property type="gene ID" value="BDCG_03565"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03565"/>
    <dbReference type="OMA" id="ASYFSYP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="117"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT00783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="393" mass="41497" checksum="E982B3BAC461B3DB" modified="2016-09-07" version="1">MSASEGSFNPPSSSLSPARTSPPRSQSQSQPQPQSQTKGSQSPSASSYLTYPVSHVVSGLYRRLTEPTPSGSTSKKPSLDPMSVSEIYNPPHRTASPFQPPPLTPLTLKAAGSPSRIFLTRSLAEEIRLLVPPRLQLLDTWQLAYSLDRDGSSLLTLYDKCREFGNKSQRAGYVLVVKDSSTAGLGGGGGGAGISGGVMFGAYLTDPPHPASHYYGTGECFLWRASVIPSTPLMQVRSTTTTTTTTSTGNGDGEEMATGAGIGAGGRVQSTEGDNNNNLLELAGLPLPPSADTTQVRGRTTTLRGASRSGSGATTPERIRFKAFPYSGVNDYMIFCETGFLSVGGGDGHYGLWLDDSFEKGVSNTCPTFGNEPLSDEGTKFDVLGVEIWYIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZB9</accession>
    <name>A0A179TZB9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 family nucleobase:cation symporter-1, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">NCS1 family nucleobase:cation symporter-1, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_02137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ER-3</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00196">
        <property type="protein sequence ID" value="OAT00196"/>
        <property type="gene ID" value="BDCG_02137"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00197">
        <property type="protein sequence ID" value="OAT00197"/>
        <property type="gene ID" value="BDCG_02137"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02137"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT00196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT00197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="507" mass="56154" checksum="D7236C7C99B7E3F5" modified="2016-09-07" version="1">MISSAMIVEGLSWWQSWICVWFGYFIAAVFLCLSARIGAVYHISFPVGIRASFGVWGSMWPVFNRAAMACIWYGVQSWIGGQCVTLMIRSIWSSYKDLPNSMPASSGTTTRDFLSFFLFSLCSLPAIWFPVHKIRHLFTIKSYYAPMAGIVFLAWSVHRASGLGPVVDQQHTVQGSKLAWAVIKGVMSSIANFATLIVNSLDFSRVARKPKDALYSQLFTIPISFAITSFIGIIVSSSSGVIYEEPIWNPLDILGRFLDGASKGERFGVFIISSAFALAQLGTNIAANSISAGTDMTALFPRFLSIRRGGYICATVGFAMCPWHLLSSSNSFTTYLSAYSVFLSSIAGPMICDYYLVRKGYIDVKELYSARKRSPYYYVFGFSWHAYASYFSGILINIVGFVGAVGITVPVGATYFYNLNFFCGFFISFAMYYILTRIWPIPATSKTWNERDIDVTNLSVAYNQGEALSIDEESQSRSPSSPVDDDLDIDVKSGRGRVDVKGFGGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZD5</accession>
    <name>A0A179TZD5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein coupled receptor family protein, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_00557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99491">
        <property type="protein sequence ID" value="OAS99491"/>
        <property type="gene ID" value="BDCG_00557"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00557"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="G_PROTEIN_RECEP_F2_4" evidence="7">
        <location>
            <begin position="10"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAS99491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="438" mass="48835" checksum="EBE61523EE391821" modified="2016-09-07" version="1">MLSRYQIHAIETSVRVMSAVSVTSSFFVILSFLWGKLFQTPVNRLMFYATWGNVLANVGTMIGGAGISHGAGSSLCRCQAFLLQWFLPTNALWILCLAINVYLTASHKYRPSELKRLEWRYLIMCYIVPLIPAFAFLFVETKASGPVYGDAVIWCWIRPEWQAFRFAFFFGPIWLTIIMTIAILLYQGIEIYSKRMKIKKLSVDAVHEISDKHHRRDTATSVQAIAPLPSIVATRADNGPGNASTFESQPSSGDVQPLGEGDTSANERTPPKTDLSTRETPERTPETTPESARSNINHGQLPTRKPSTLTLGPTFYATGAAQDESRSNYEQHGTPVSSGTTDARRNDLGLDELENRSAASSAPTAYAQVRSHDGASLGPTRTSSLSQNRTWRTRLPILRPLQTADRHTATYLHPPPLTVSIAFLIRMTQYLVWLFYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U090</accession>
    <name>A0A179U090_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_16928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01133">
        <property type="protein sequence ID" value="OAT01133"/>
        <property type="gene ID" value="BDCG_16928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16928"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="117" mass="13442" checksum="94C5BDB10A95A3FE" modified="2016-09-07" version="1">MSWRKHLVPFLPTAPQPTGKYSVSRNVTGSNQYHCEKQANFNIPINFPPHFGGLPYQIVGRRIPRCFIFLKPCLLGIRKKGGKKQYLGNFELSLNISFPTLPLFTLHLPCTEHHSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U094</accession>
    <name>A0A179U094_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA splicing factor, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_05499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01556">
        <property type="protein sequence ID" value="OAT01556"/>
        <property type="gene ID" value="BDCG_05499"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05499"/>
    <dbReference type="OMA" id="IIGNGPM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PTHR13904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="9">
        <location>
            <begin position="119"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT01556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="461" mass="49288" checksum="0299835A9F32357F" modified="2016-09-07" version="1">MILVHKFIRDHYSTRFPELETLITNPLDYAKTVAILQNGPLDDIKSLSTSTDNLVGATLRSVLDGPSLMIVAVEGTTTRGRELSQTELETVLDACKMMLSLDRAKGILTDYVQSRMNVFAPNLTVLIGSLTAAQLLNYAGGLTGLAKTPSCNIPPLGSKKQTGTGFATNVGVRHQGFLYHSPIIQEIPNDLKRQAMRIVSAKVVLAARVDRVHSSPDGSTGEELKQACLDRLEKLTEPPPNKGPRALPAPDDKPSRKRGGRRARKAKEATAMTEIRKAQNRMAFGKEEKEIGYGTGEGTKGLGMLGQEDHGRIRASQIDQRTKAKLSKSNKGWGAATPIGGTASSLRGFGQGAGNATVLRAQGLRTAGVGPSLGAGAGIASSIAFTPVQGLELVDPKAQAELNRKRKAEEDRWFKSGTFTQVGNQNNGGNSSGGFKVPELPRKRLDTGDTKMPPPPPPTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U098</accession>
    <name>A0A179U098_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01143">
        <property type="protein sequence ID" value="OAT01143"/>
        <property type="gene ID" value="BDCG_04417"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04417"/>
    <dbReference type="OMA" id="ECEELFV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HeLo" evidence="2">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="609" mass="68431" checksum="EC75DDABE38EC63A" modified="2016-09-07" version="1">MLDPGSIIALTLLAYQGADHAWHIFQDTLHYASDSEDLILQLELERFRFQTWAKNAGLEEGELSPGLLPVYEIVERTLKVIGQLFENADELRERYGLCASQSEALEPDKVKRFITKMRKSLRASGIKLDVRGESEEINGNEQSYASEVGRPVGRAKRLRWGVRDRKQFQKLITDLESHVEKLNQLLSETQQRSLIEDRKRIDIVFVGNANDNGSLQWIRDALGQEPQTSSIRALVERKALAGGRPVTTRSGPAALSPLTLNDFSIPPGYHGQSRFIAKSIEPSEYVLLEKKSYGSDISVQDKQILTMRVNRLVLLLSAHKSPDFQTLQAIGLIHDPANLCWWIVFKFPITGIPMITPNAVLAQPVSLLALLESKLRPPLETRLCLASKLAITLSELYGSGWLHKNIRSENIVFPALYGGKSNSKREPLSPGINSSLLLSPLVAGFHYSRQETETQTIDKNQFHDDIRPVIYRHPNYQGEAAQGYRIDYDIYSFGLVLSEIAWWVPLSSFLDAKVPIESAPASISSSTQIRSSTTTTLAISNPATAVQLSSSMKRFQRPEALELRRRVISRADPQYARTLRLIPLLPLLQLRVLLIGTQHWNFTIGLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U099</accession>
    <name>A0A179U099_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
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        <property type="protein sequence ID" value="OAT01566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblFungi" id="OAT01566">
        <property type="protein sequence ID" value="OAT01566"/>
        <property type="gene ID" value="BDCG_05541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05541"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="PTHR22792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="684"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
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            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
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            <end position="236"/>
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            <end position="320"/>
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            <end position="418"/>
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            <begin position="425"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="880" mass="94672" checksum="4856B3926C15B147" modified="2016-09-07" version="1">MSTSTSRPGLEMPAFSYAQAAKGFSTPPSVQIVAEKQNKSSTTSSDPSSHRTATGSVDGDGSNRTVASSTDLESSSVATEPADATDKSQSSSERSSDWTVTPPAAGAPWKTATSGTSSPSVGTTSTTTLPKEDDTSGTPNGIPDSSWDKQSQVSGTVEKSSESGESGKEKLKENGWEKDVPVLKELKAAPIPAVNVWQQRREAQEAKAKASAALKSTTTAAAKPFNSKSSVPSENRAEGSKGGPRKKAGGSEVAADAAIAKKKSSESGKSKEEAETLPPVGDASSWPTPQLAQGEEFRKAQEKSDKTEKSEKEKAPTAGSRGKEKWMPVPYVPTAVFNTPLPPAARRGGRPSRGGREGGMRSGAHPSAAISSSDRSVPASASAAGGSKQTGSSDRGRSGTRVDSDQSGTTQPARTGSVNAPLSPDEKKAPHDSRPDRASSDSKSVKAPEEPRGTTGGETQTNHPAAETGPRQRQNSKSFGRSHDYSNVTSQRGTEHTGRHAGVQGDSHAGTRFSSGHERRFDNGPRSAEFYKEPPFHPRDRELSNQREREYPRERNDFHRDREYGRERGESRPERGRGGYRGRGGHSNYSGAHNSQYHSPPVGQSQFQSTKPFSLSERHRSHHQASQNGGQQHGSNRGLNMRSPSLPSSGVYGPTPYPIQTDLNAMYGYPVLHQGPMTAIPYHPYMEHSLMSMISMQLEYYFSVDNLCKDLFLRKHMDSQGFVLLSFIAGFKRIKSLTEDMDFLRLVCRQLKSVEYRPGEDGNDRLRKREKWEQWILAMENRDPSAQNEGPPPLSLSTPAHDGNSDGLNSSHLETTALYGNGSLHEISGNAIPSHYSLSNGATSDTRVHQSVLSSAAPEFSPAYVPVTGQNENANQRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0K0</accession>
    <name>A0A179U0K0_AJEDR</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="3 4">
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Blastomyces</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAT01654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OAT01654"/>
        <property type="gene ID" value="BDCG_05758"/>
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    <dbReference type="Proteomes" id="UP000002039">
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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            <begin position="28"/>
            <end position="49"/>
        </location>
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            <begin position="58"/>
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    </feature>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="86" mass="9809" checksum="CE71BC4BF6ADF7B5" modified="2016-09-07" version="1">MWGGRGEELLPFQQAPMDIYFSLAEKRLATSVAFAWVSYRFGLTILRLLRKYLNRAAVRRRQARRSSRVGQGSQTTETDNATVGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0K1</accession>
    <name>A0A179U0K1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF hand domain-containing protein, variant 2</fullName>
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        <submittedName>
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        <submittedName>
            <fullName evidence="6">EF hand domain-containing protein, variant 4</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="ORF">BDCG_03612</name>
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    <organism evidence="4 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ER-3</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
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                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT00800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00799">
        <property type="protein sequence ID" value="OAT00799"/>
        <property type="gene ID" value="BDCG_03612"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00800">
        <property type="protein sequence ID" value="OAT00800"/>
        <property type="gene ID" value="BDCG_03612"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00801">
        <property type="protein sequence ID" value="OAT00801"/>
        <property type="gene ID" value="BDCG_03612"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03612"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
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        <source>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAT00800.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="310" mass="33966" checksum="DBAF69459C687B10" modified="2016-09-07" version="1">MLGEMSARQDPNRERPPMPPPKNGPPPQQTRISPTQRPEPHSQIPTQHSYARTGSGGGPGVVPPGAVQATAGQYGGRGAPISSTSGRLYSPPPRNYGFGPPPAHPAQNRPTPTCGPPRSPQPSGPGLPQSDDPKELFPLFRAANASNSGALSETELGSALVNADYTSFDAYTVKMMIRMFDKDGSGSVGFDEFVALWRFLAAWRELFERFDEDRSGRISLAEFSKALIAFGYTLSPPFVGMIFSIFENRARNKGTPIPGQKDGMSFDLFVQACITLKRMTDVFKRYDDDRDGYITLGFEEFLTECLRLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="3">CFEM domain-containing protein, variant 2</fullName>
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            <taxon>Eurotiomycetes</taxon>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02785"/>
    <dbReference type="OMA" id="ANSTCEV"/>
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        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
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            <end position="86"/>
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    </feature>
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        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="336" mass="37145" checksum="90659E82198F7700" modified="2016-09-07" version="1">MISKAPYFGGQFHADDWTITVAMVFGIPLGVLSVPLANAGLGKDMWNVQFDKITYILKVYYVQEVMYFVTMNVTKVSILFFYLRIFPSHKFKIACYVVMSVTIAYGTALVFAALFQCNPVHLAWEHWDGEHTNYKCSNINLIGWLSAAINIVLDIVIITLPVKQLLGLSLSVKKKIHILLMFGVGFFVTIVSIIRLKSLLQFGNSHNITWDHVPVGYWSTIEGHASILCACMPAIRALLRKLFPAMFGDRTGASSSGTRKIRTNKLSSSNVKIFSSQGHVPHSPLSPRSPHARNSLGKGGGTVSLESDIFPLVERGEVGPGHGFGSYTIVKSVYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0N7</accession>
    <name>A0A179U0N7_AJEDR</name>
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        <submittedName>
            <fullName evidence="5">RING finger domain-containing protein, variant 1</fullName>
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        <name evidence="5" type="ORF">BDCG_02875</name>
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        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT00461"/>
        <property type="gene ID" value="BDCG_02875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02875"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="387"/>
            <end position="430"/>
        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="453"/>
            <end position="510"/>
        </location>
    </feature>
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            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="553" mass="61199" checksum="8D7FBBE4143A004D" modified="2016-09-07" version="1">MRLSANAFDAVVHAIPSEGSSLTRPVPVDSSISFELSIGDKIQTLSTTNVRNGDAIRGLLYVPELDFEDPCRQATTPFILANVTRLSDIPGPRRSISLAPWVSSACTISFLAALSRNPPYAAVFYRPDESTTTPPLADHPTWDLGDRDMWKTTNRYPVYAIPGVYGASVMRALSEYSGSVADAPYAEDLLRRFQGSDVVRVSSKIAISKNSTGGLPSLWIFLLVVVAILICIALFSSIAMRCIQARQLRSLERRVAAGEVDLETLGIKRLNVPQDILDKMPLYICNGSGRIERLIPPTTEMTPESIDEPSKLPPDKGSFLQSISGWKWISRVSQAFYSRKSRSTTPPPPLSSAPDSGTSLPSPRSQTTPIDNNQQHHAEPTFAQTTCPICLDDYDWGETTVRELPCQHIFHPECIDNFLLQNSSLCPVCKKSVLPRGYCPEKITRVMVRQERLARRARPPQTIEIGNGGYDAAMPTSLGNGNQSPQNRSRTGPQATVSPPTGERFSRQRQEEMRMRAVAMLGYRPMIADEERAQDASRSKLRKLLQILFPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0X5</accession>
    <name>A0A179U0X5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_01815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
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            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT00032"/>
        <property type="gene ID" value="BDCG_01815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01815"/>
    <dbReference type="OMA" id="RILYNDW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="PTHR35020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="219" mass="25386" checksum="FAB05D5A46554F95" modified="2016-09-07" version="1">MMPHLNDPAAPAAVAETADDARITPLLTTTTTELVDEETAITTPAEPLPYWLVNVPRSQWPPECPEYLRDLPQKSIKCLSTPDAQYERQSWALVKEIVGSNQIHLLQRVPSELRRYLEYTAKIKDKYGSVLNFVVQKRLGWVDDLKPRGTRPFDHPDDIKILYNDWPYGVEKDIVHLVIWTKFELEDDPATDDLTPRMRREIDEFVEKTFRSRMPAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0X8</accession>
    <name>A0A179U0X8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome biogenesis protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_05026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01373">
        <property type="protein sequence ID" value="OAT01373"/>
        <property type="gene ID" value="BDCG_05026"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05026"/>
    <dbReference type="OMA" id="DWSPLQP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1C_H4-bd" evidence="5">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT01373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="427" mass="46777" checksum="F373575761689024" modified="2016-09-07" version="1">MDVDKQTFIPGRTKLAPGETLSPDPTTYEMLHTLSTPWPCLSFDIIKDGLGDNRKTYPATVYAVAGTQADRLRSKENELMVLKLSGLSRMERENDSGSDDESDDESSEPILESKSIPLSHTTNRIRAHQTPSPSGDYSKPPQTITASMLENAHVVIHDVTPYLSTFDNPGSIIPPSASKPLSTLRMHKSEGYGVDWSSLHPLGKLLTGDNDGLIYATTRTEGGGWVTDTRPFIGHTSAVEELQWSPNERNVFASASSDGSVKVWDVRSKSRKPAVDVKISNTDVNVMSWSRQTFHLLATGADDGQWGVWDLRHWKPNTSGGASQLKPKAVASFDFHKEPVTSIEWHPSDDSVIAVSSADNTLTLWDLAVELDDEESRDSAGLADVPPQLLFVHYMESVKELHWQAQMPGTIMATGSGGFGVFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0Z3</accession>
    <name>A0A179U0Z3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn(II)2Cys6 transcriptional activator, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00052">
        <property type="protein sequence ID" value="OAT00052"/>
        <property type="gene ID" value="BDCG_01844"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01844"/>
    <dbReference type="OMA" id="EYFQLYH"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="430" mass="47762" checksum="030CB818EB1632A0" modified="2016-09-07" version="1">MLCGMMMQIAMQIGLHRPSHAQDFSKFRIEFREGELKDRVKTWGVCNIVAQRVATGYGQPSQTLLDWTLSSPESVDQNFKLPPEIKCRLDIEKFCDKVTRGLYSNPRDPVGLSSDDERFIVTTILAKDFEELEGQLRQEHNSITNLYLRAAGLHLRLSAFFDNPTAKDYRQGLLALYLATTLFLDEALNLETSDGPVLAYSPNYIYQMTLAAGFILLKLCKSFFAVHIDMDYTKTLFNRTIWAIRSMSVTNNDLPERLAEVLAQMWRTGGAPVSPYVGSSSVRPDMDDTLQLKVRCRMSMSLVYDSVWRWREDFQAKGRNLESFLKNPTNPDSNADSSASSVAPLRASSSTPGIPGADSNLASAPPSHSTNIGGEGSLSTAGPGNGMGILGGFMEPNYEVFDPLNWMLDGLVDFPYSFNQVQGLESQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U191</accession>
    <name>A0A179U191_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Maltose permease, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_03350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00681">
        <property type="protein sequence ID" value="OAT00681"/>
        <property type="gene ID" value="BDCG_03350"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03350"/>
    <dbReference type="OMA" id="RIVGYCL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT00681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="436" mass="47210" checksum="95564505B9B05AA7" modified="2016-09-07" version="1">MLGALISAIGIAICFASAFAAGIDARRGIFLVGKLVEGFAAGQVVCTVQIYTSEIVTRALRGSSQALLPVMTMTGQLIGALVVFACLSVKGRDGYLIAVASQWLFSVILLFITIFIPESPPHLIRVGKIDQARKAQRRLHRKEVDTDKMVDKLVEILEQEREMMKRLGSQVRFIDCFRGIDLRRTIIVLVCHMMPQNFGLGLLSTASYFAQTVGIPPFLSVLLLEIGIAVGLVANIISVWTLSVAKRRPLMLWTLGLTGLFWGAIGISGCFDSPVTKWITAAGMIVIIFVCGNGIWPVSVLATAETSSLRLRGRTQAVGWAMHGIYACIFAVVLPYIYNTDKGNLGAKTGFVFFGLSVLSCGLIWMLVPEMGGRSPAELDLLFEHNVPTRDFLKWSAEKSSRKGPDAVASAAASAAAVSDDEKNKRSSEHVEIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U199</accession>
    <name>A0A179U199_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_01998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00142">
        <property type="protein sequence ID" value="OAT00142"/>
        <property type="gene ID" value="BDCG_01998"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01998"/>
    <dbReference type="OMA" id="LSICVGM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin large complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="PTHR28520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT00142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="80" mass="8571" checksum="38D76E1B4FCD6B88" modified="2016-09-07" version="1">MPPQPQQQDDKRQAAREVIDILHEISTILNTHLDRTELSLCVSLIENGVNPEALAAVIKELRREAVAAAATTSGAAAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1M8</accession>
    <name>A0A179U1M8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_17348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02036">
        <property type="protein sequence ID" value="OAT02036"/>
        <property type="gene ID" value="BDCG_17348"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02037">
        <property type="protein sequence ID" value="OAT02037"/>
        <property type="gene ID" value="BDCG_17348"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_17348"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="101" mass="11193" checksum="7ABEB588BC892DFA" modified="2016-09-07" version="1">MLKKKMKKKKRDLKNPQDKMPSHPTQATKRSLLHADLLPLATIALPTNQHQPTPPSCSLPSVCSVSKYSTHLASHDPPADWTGLGWLVTSLQRTSGQRCMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1N4</accession>
    <name>A0A179U1N4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-14 protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_06492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT01994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002624298.1"/>
    <dbReference type="EnsemblFungi" id="OAT01994">
        <property type="protein sequence ID" value="OAT01994"/>
        <property type="gene ID" value="BDCG_06492"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06492"/>
    <dbReference type="eggNOG" id="KOG4159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="379"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT01994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="469" mass="53359" checksum="C3150A1E48DE8150" modified="2016-09-07" version="1">MKFARDYTQILNAEDYPAQWVQSAISYKRLKKCIKKVCTELLSLGLRPEILNLLWHQSQAAKARGYDGAGDDSRPFGFQYSLSKNPFTSFWLPKLTFVIDPMDGSPIDAFVSPRTLEFLQQLNKIPLPIPAATLARLDSELGSFTDDGCLEVVADGELSLVKRRISLESVDENAETAHSVEIPLSADSEFFQILNKELSGLDKLQEREQIVLNERAKNLRQQIVKITKPQFRRSQSALYTWREIFRLYIDMQVFFCTDEQGSGQRDSKAASQQLEKFQATLTKDRRIKKLGKEGRAALETFLCINNALLQNLKFQEINRTALYKILKKFDKRTALPAGTIFPELMVVEAFLAETMAKAVCYTISEEVLTVIPQLDDYLCPICFNISFKPVRLRCNHVFCIRCLVVMQRAKQDKCALCREEVVLSATGANLDMELLAFLAASFPKETKAKQKENERAAMVDLYATVFNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1N7</accession>
    <name>A0A179U1N7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01219">
        <property type="protein sequence ID" value="OAT01219"/>
        <property type="gene ID" value="BDCG_04611"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04611"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="312" mass="35369" checksum="18CD0F293F712DBC" modified="2016-09-07" version="1">MYQYPPQPPHGWSTYDYATTSPPQYPYYPSNYASPHVSPRTKRHSHRASYSAAKEPSSGWHSMPPGYGSYYDSVHGYSSPPRKHENIPVYDEADSPKRSRARRASTSARTPQKPKPSTAAGASKHAKATEADAIRMGIPEGYSIKNWDPNEEPILLLGSVFDANSLGKWIYDWTVFHHGASAPMADVAGDLWLLLIKLAGKVKRAQECGPRIRNTEAREMVEDFLESGERLWHRFEKLLKACEHFMWKAAKRESGKGGPVMMGRNAGCEFVDSIFGRDRELENTEKLMNSIRLWDMRFDANCDEILRRPTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1N9</accession>
    <name>A0A179U1N9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_03673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00831">
        <property type="protein sequence ID" value="OAT00831"/>
        <property type="gene ID" value="BDCG_03673"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03673"/>
    <dbReference type="OMA" id="MNMIFTW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:cellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="PTHR12483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="160" mass="17744" checksum="1A433CDD303E438D" modified="2016-09-07" version="1">MDHSMHQAGMDHGHGDMDMGDQCSMNMHFTFSSHNLCIIFKQWRITGPLSLLFSLVAIALLTAGYEGVRALARRYEARHALALKDGTIPPAGGYTFARTDRRRRGKLVLGALYAVQVFYSFMIMLLFMTYNGWIMLAVAVGAFLGYITFGGEATKPASCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1Z5</accession>
    <name>A0A179U1Z5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAMK/CAMKL/KIN4 protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_04956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01338">
        <property type="protein sequence ID" value="OAT01338"/>
        <property type="gene ID" value="BDCG_04956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04956"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="307"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="980"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="757"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="885"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1134"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT01338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1175" mass="128257" checksum="79271FF9758D69F1" modified="2016-09-07" version="1">MSSAMQTVSQHSTTQSPSQYASTGSPRHPIHQTPVGPRQSSRHRTDHAAARNSPVSPDQFYSPTSAVTSTMNSPQHLPLPPSTHGSPVTPSTGQGSSSNTRPRPTPTLSDGPGSPPIPPPRTSSNQRSRTSSTAPSANASTERVANPKHSRRRGDGTRDRGDRDHTHDTNGRDMPNDDTPSGAAKRRKGPHSPDGPQRAASTREPRDHASPSAMETRSEAAMGPTPIPAGIEKQGSTVINRMVITDPEVDIVREKERLAEAQPAPDSLSGLGLVSSEGVDDGGRGARSRHDYSNSSSRRKETTFGDYVLGQTIGEGEFGKVRLGWKRDGSVQVAIKLLRRDSLGNNPSRLPKIYREISILKELSHPNIVRLHEMAETDRHIGIVLEYASGGELFDYILNHRYLKDNPARRLFAQLVSGVGYLHKKGIVHRDLKLENLMLDRNRNIIITDFGFANTFDPTDELGDEIEYNLTNREFVKRMKLDRPNAKGLRRGDLMQTSCGSPCYAAPELVVTDSLYTGRKVDVWSCGVILYAMLAGYLPFDDDPANPEGDNINLLYKYIVTTPLTFPEYVTPHARDLLRCILVPDPRKRADLFEVARHSWLAEYAHVVSHITSNTTNVADIANTTVPAEDQQQTPSLARSASVREPPKAQHQSNVSPVGGLSHQPGKISQDDEKQKPRDAKRRTVQVEYVPPQSQTARGDSTTASSSLGPTSGHAGLSQGRPMSSGREPPSSAGAAAPAKATITSRSKPLPRDPPVNTHPTSYNTTDRLQGTLSQTTRPQTGGSLASTGAGKYDSRLPSRGSYSQPAAPAVATTNVQGRLAQPKNGKTYSVSPPIAQQTTESSVGRPSTNQDYSAVQQQAQTKSHKRSSTVSSIGEKLFGRSGSIFGGRSSQHGQRSSKRYPPTSMKEPIVSDEPRASMDSRRSISHSFHRRHVDSSQEHSAKPRRFSLLPASFSLKAFSSSKETPPTADSHIAQVNDSVHAPESRGHQQQQQSQSLSTANASSQSHHPRAADHTQDEQGFGNTNDQLNMMNYSAQIDQQFAALHGDSEPQYESNPYGSPHIAAEQYYQEDPRANSSSARYLSEPQSSSYTEQFMPSYPEGYNPGHGNGNDSRQSIQPSHQSGRGSNVLQKNHRRFADAYEHEKDPSNHSGSSGAARRVMDFFRRRGKYRAGDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1Z9</accession>
    <name>A0A179U1Z9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="8">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDCG_03916</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + NADP(+) + nitrite = H(+) + NADPH + nitrate</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="8"/>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT00951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00951">
        <property type="protein sequence ID" value="OAT00951"/>
        <property type="gene ID" value="BDCG_03916"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03916"/>
    <dbReference type="OMA" id="TAKAMMP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="PTHR19370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0274">FAD</keyword>
    <keyword evidence="12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0349">Heme</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="15" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="329"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="431"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAT00951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="689" mass="77064" checksum="E9AF0CCC1B74290D" modified="2016-09-07" version="1">MSSILLKAKLLQSARYVCMEGVDKLPNGFYGTSVKLNWVMDPNKRIMLAHKMNGEPLRPDHGRPLRAIVPGQIGGRSVKWLTKLIISDIPSDNWYHLYDNRVLPTMISPEISTNEPKWWHDERYAIYDLNVNSAVVYPEHDETIVVSSSSMYNVKGYAYGGGGRRITRVEISLDKGKTWRLANIEYPEDKYREVDQYLYGGKIDMSWQETCFCWCFWALTISTTELKNSDAILVRAMDEALNIQPRDMYWSVLGMMNNPWFRVTITKTDGYLRFEHPTQPALIPGGWMERVKKNGGDLANGNWGAVLEGSENIAAMEAPKINLKKPDLDITISLERFKSHKTGPEPWFALEGEVYDGTAFLNEHPGGAQSILSAAGLDVTGEFMAIHSETAKGMMRDYHIGSLDISSQEALQNDIDVESLSPSREVFLDSKLWAPSSLSSKTVISPDSRLFTFKLTHDSQCLGLPVGKHVMLKISDPSTDETIIRAYTPVSKQTAVGTIDILIKLYAPTPDYPNGGKMTMAMDKLPLGAMVKFKGPVGKFEYLGKGAVLLNGEKRYVQSFHMICAGSGITPIFQVLRTVMEDTEDHTSCVVVDGNRTEADILCHAELDEFVAQDSNGRCRIVHTLTQPSATWTGRKGRISEDLLLEYVPVGRKRGVKSLVLVCGPEALEVAVKNVLLRMGWDKDDLVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U211</accession>
    <name>A0A179U211_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_06871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002621651.1"/>
    <dbReference type="EnsemblFungi" id="OAT02155">
        <property type="protein sequence ID" value="OAT02155"/>
        <property type="gene ID" value="BDCG_06871"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06871"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LWPGQSF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="55"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT02155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="336" mass="38372" checksum="26FAFFF41F8D9ACF" modified="2016-09-07" version="1">MPSHGRRPLSLRLYKPPFRTSCSSRLLSCTPSIFRPLTTLQKRTMSELTHPTIKDGWFSEVSDMWPGQALTLKVNQILHHEKSKYQDVLVFESSDHGTVLVLDNVIQCTERDEFSYQEMITHLAMNSHPNPKKVLVIGGGDGGVLREVVKHESVEEAVLCDIDEAVIRVSKKYLPGMSVGFQHPNVTVHVADGFKFLADRKNEFDVIITDSSDPEGPAEALFQKPYFELLFNALREGGVVTTQAENQWLHLSLITDLKRSIREIFPVVEYAYTTIPTYPSGQIGFMVCCKDKDRDVREPVRSWTREEEEKLCRYYNKEIHRASFVLPNFARKALDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U219</accession>
    <name>A0A179U219_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS sugar transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_04495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT01177"/>
        <property type="gene ID" value="BDCG_04495"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04495"/>
    <dbReference type="OMA" id="YPCLLFE"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate transport"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
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            <end position="24"/>
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    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000002039"/>
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    </evidence>
    <sequence length="419" mass="46880" checksum="C601A788D3570A6C" modified="2016-09-07" version="1">MFQAGRFVSGTAIGILVTVCPMYLAEMSSPFVRGWLVGHHPIFLVFGYMLSSWVGYGCYFATAKSPTFAWRFPLCLQTLSPLVLLIGSPWLPRSPRWLISKGKLDEAWEVIRRLRQSKEDPDNLVAKEEFIQTKEQLKLEAEKLATTGHGVWTAVFKKKSYRKRMTIGFLTQWGAEFGGPLIINNYAVLLYQNLGMTGHMPLLLSALWLTTAGLIYNPGGAWLHDKVNSRRGMFLVGFIGIVVTTSCLAAMTAKYAGTLNRVGNGLGIFFIFLYLAFQGTFCDTTMYLYVSEIFPTEIRPIGMGFSLFGQFASTIILLQTAPIGFANVGWKYYLVIICWSAFFIPVIYFFFPETARLTLEEIAKNFGEEVAIVTPHAADEERRALDHKLQSSGVTRSTTATSQSDSDATEAAEQRRDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2P0</accession>
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        </submittedName>
    </protein>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
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            <dbReference type="PubMed" id="26439490"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
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        </source>
    </evidence>
    <sequence length="2190" mass="236029" checksum="7BB14FC3DD7089AC" modified="2016-09-07" version="1">MLYATAAEPPHNNNNNNNNNNVRSMLIAPANPPPPAKPELPRKRAWCSGDIMTKSPDGYHARNGGGRGREAVSERRSTELKTGLRRAAGFLTMDCCESKSTTLLDSAHAASLKASALVAEMLLSLDSTPLPYGAPPPPYDNVITDMPPEYMSRDEFAHRRVETPASAPTSAVWTETAKGNGLLLGEAVTPPAIDFNDASKFRSHAKKKGKATKKANQDKWNEPEKGGDKGNAAGGDGDGGGNADGGAGNGDGGGDGAGGAGGGDDGAGGGGGGGDDDDGWDLGGSKKKNKKKNKKKEEEEEKKRKEEEERKAKEEEERKAKEEEEEEEEAAAASAAADDNAGNSLSWAGDVSEANADDAWGGFTTTTKKKKGKKNKASTAADPPTAKEPASNSFQDINLGDEPPQLDFSLESGGDTGKTGFNFGAWGNSWNTGNIDLNLGDTQATDEKKDDGTDTLDPWAPAGKKGKKKNATTNTFEFGDSGDGNTEEKKEAEDDAWPSFAVVGKNDKKKKKKVSADIAEEPVPDPEPAPEPAPVDEWNSWSTPSTKKSKKKKGTNSFGAIEETPPEPEPEPEPEPEPEPEPEPEPEPEPAPEPAAEDDAWGAVGKRNKKSKAKTADEPPKEPNPPPEPVVENTWASIPTKKEKKKKNRGITEEPSKEEVPEPEAEPKAEPENDWGWAAPAGNKKKGKKGAVTAVTEEDKPVEEPPAAQPEPEPQPDPVDDWSTFATTTSGKKKKVKKGAVVAAVEEEKLVEEPPPPPPEPEPQPDPVEDWGGFTTTTKKKKGKKRAVGEEPVPDPAPEPAPEPEPEAKPEADPLEEDWGFTATTTKKSKKGKKGAVVEEAPPKVEEPAPVAEADIWDTGTSKKNKKKSKTTKTEEGPAPEPTPAGDDLDWLNDDLGDGGKVTKVDSKNSKASGGSGADGDGWGLGGWSFGSKKNKKNKAAVVEESNIVPEAPAVTGTTSIDAVDDWFGTKGSKKDKKGRQDPIPEKSPIEPEPEKATAVANDEFLGWAGTTSTSKKNKKKGTKAAEEPLPPPPVSEAPEPPADDGWGIWGTSKSTKDKKGKKNKLVEPEPEPEPEPEPEQEPVPEPEQEPPKVDPEPLVEAEAVDPWAGLTAKERRKKEREAKKQAAAAAESNENNAANAVSTDLVRSPALDDNSWGMWGAAADKKKGKKGKDTNEPPPPAPTPPAQDLEPEPAVVDIEGIDTWGAFTGSGAKTPKTKKTSLSRTTTTTSKSPKVEDGKSTRSKSRGFEVVDVTDEFKGKEEPMVEVSAARAAKSFWGGTFGTATTTPITKSKTSKSKEDANKQSVEATKDKLAAEETKKGSNADNLLADTGELEAASATGADKATAPSAPTTKTTTTSTGSIKVTSKTSVAERIKLLEESKKREKEALKEKEKLKAKEKAAAQTAVPQQPASPLDVKPTVDPVANDPPPSKKASVSSKTKSSTVPSNSTSKKNSATAAATATLLDGSSTPRDSVPGSFPGAYEDELVEIVDLAPPPEPTPVQSQPVKASKKSKKASPVKAVIVDEMATPPPPPPGPVPPDENKDAEAPPDRATAKPAKKERPRVERTAGASSWGFWGAAPKKPVKKETKAKDDAGPSSPSTKKPKEKSPPALSRSKSMSSKKGKPADAEKDVEKSSGSDEKRNSTAVRPRHSRGMSFSNFMMGGILSPNGGHAEMSGKAAKFMGVNGTKTPRRDPNGKKRASRAPDPYAIDDDDDLVMVNGGDVPEASSPKDSPVDSKPRRRKSKREQKPRSADDDIVMVEPGPSSRPEVVSGPEDLAFVIDPPKERANLKRSNTTATPKKSEGLLGLFGSFRKHAAPPPEHSRSRSYREEDLRKSAEIDKEYARRARREKRRSTRVETDGEGFTTDAAPATEAEDAEARRAERRARRLSKYAEQEAREAEEREAEERRAKRREAERVRIREARERRAREDEEREQRHREEKRARRAARLLEEQQREEEIRQLEARRRAREADEFGEDGRRVRSERHRSYTDKARDKYSHDEYATDHRRHRSHRSGDEAAKSRRRKSAVLPGEEYYTSRKGHSSRRASNVPYPGIAGAGKDKTSSWLNSQLTDPPEAPPIVPTVIDVPAPPGDPHVHSLSSEEEARRSARRKARRHSKYNGVDDAEATERRARRHELRHSVRGPLKSSEGSGEGDRYGDRYASDYHRHSSYANGAPKRSSWFKKITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2Q9</accession>
    <name>A0A179U2Q9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA ligase</fullName>
            <ecNumber evidence="11">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDCG_05198</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="11"/>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01437">
        <property type="protein sequence ID" value="OAT01437"/>
        <property type="gene ID" value="BDCG_05198"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05198"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051103">
        <property type="term" value="P:DNA ligation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="PTHR45997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 11 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="14">
        <location>
            <begin position="426"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="15">
        <location>
            <begin position="720"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="15">
        <location>
            <begin position="898"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="863"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="868"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAT01437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1023" mass="116506" checksum="6AF32CE57C4F8EED" modified="2016-09-07" version="1">MDSDGEQEPDGLRQADPNGEADLDERYPNRPRNHSPTLPFHDLFLTLFNPLNENKKRPTGPALARRKVGPHGHGAAVHLSPQERRRDIIQRFISRWKKEVGDDIFPAFRLIIPEKDRDRAMYGLKEKAIGKLLVKVMKIDKNSEDGFSLLNWKVPGQIFASRMAGDFAGRCFEVISKRPLRTEVGDMTIEEVNEQLDKLSAASKEDEQVPILAYFYRMMNPEELMWLIRIILRQMKVGATERTLFNIWHPDAEALFSISSSLRRVCWELYNPDIRLEGDEAKVTLMQCFQPQLAQFQMQSFERMIQKMRLAEDDPTFWIEEKLDGERMQLHMESDDSIPGGKRFVFWSRKAKEYTYLYGNGFFDENGALTRHLQKAFADGVQSIILDGEMITWDPEHDAIVPFGTLKSAALAEQRNPFSTGQRPLFRIFDILFLNGQPLTRYTLKDRRRALEASVIPVHRRFEIHTYEIGHSAADIEHLLRKVVAEASEGLVLKNPNSPYRLNERHDDWMKVKPEYMTEFGESLDCIVIGGYYGSGRRGGALSSFLCGLRVDESHAKKGDHPTKCYSFCKVGGGFTAADYANIRHHTDGKWIDWDPKRPPTEYIELAGGDLQYERPDVWIKPEDSVVLCVKASSVTPTDQFRLGLTVRFPRFKRLRMDKDWHSALSIQEFMDLKSNIEREVKEKEFKVDDSRKLRHRRTTKKPLTVAGYDGGKKTKYAGPSGKLFNGLNFFVMTESVHQPKKTKAQLEQLVKANGGKIYQTNTAAENTICIADRRTVKVASLQKNAKENVIRPSWLFDCLSQNERDHGLPDLLIPLEPKHMFFTTVDQEEEIAGNVDKYSDSYARDIDASELKKLLDAMAPAPGLPPSNISQLESQLESHSLNEQESPTATVSNNPLSPGWLFKGLVIYFATPPSKSNDEKGKKPHILAQRLQLASNLVEFAGGEAITDDSDMKDPRITHIVVDSKSSGDKAGMLVTNVAEIRRAISSLAGVGKQIPHIVGVEWVEESWRERTLVDEERYVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2R2</accession>
    <name>A0A179U2R2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Folylpolyglutamate synthase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_07305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02344">
        <property type="protein sequence ID" value="OAT02344"/>
        <property type="gene ID" value="BDCG_07305"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07305"/>
    <dbReference type="OMA" id="HFSEERD"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT02344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="353" mass="38653" checksum="4A632DCBCEF2CA1D" modified="2016-09-07" version="1">MFTRYLFEVWEMLVSAEIDRLPRYLQLLALLAFHTFVKEKVDAAIFETHHGGEYDATNVIPKPVVTGVTSLGMDHISQLGPTIEDIAWHKAGIFKAGTPAFSVLQEDRPSVALSKRAAEKGVDLTFVSTNEALFDGGGVLNIPVQRLNCSLALEIARAFLKLKAPEDTIDAEDISRGIKTFSWAGRFEVIEDGISRWFLDGAHNMMSLEQAVQWFSNATNAPDSQKFRVLIFSHFSEGRDGAALAEGLAHSLSKYNAAPDCVIFTTYQESEGGSMGKDRTVKLAEPSFPEFCDLYSSIWKGLNPQGVVSCEPTIEGAIKFAKRMGALHGGMEVLVTGSLHLVGGALNILRPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2R4</accession>
    <name>A0A179U2R4_AJEDR</name>
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        <submittedName>
            <fullName evidence="3">Zinc knuckle domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_03377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00692">
        <property type="protein sequence ID" value="OAT00692"/>
        <property type="gene ID" value="BDCG_03377"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03377"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="584" mass="63817" checksum="DA1B2D0B8D0C1AD8" modified="2016-09-07" version="1">MENNTAMENKSSDDTTTDLAPSSVSPPASRGMAPAMNWNKLSKGTVRTVLRGRRQADTPNSSAANSFEAVNGKYWRSRSASASSAGSGDGEHHRRMHGQGQSDSETDACRSKAHVGTNVGQKTFTAEFSDMDSGDDTDGNNDIVLNLSGLPKTDERIEATGELHGPGREMAHQGSDVPGVQKLNGEILSEPHGSNLSVQTENKLPEDEIYCDGNRGNALSGGPKAEAIRLFRAKYPSDPTTLADLTRVDLETQARYIFLDLEPEDLDLSLPITCIDCMKEGHLADICPNKECEHCGAWSVHESRFCPSRRRCQRCRERGHDAEACSSLLKGSAAEEPCDFCGSGDHTECECDLIWKLPKRNPTSGRIFISISCCHCTSNRHLVGDCPTRNFPMNSSSFSLKHFDPSVFSNLNTFPVTISGKGTSSQRNSGYKIRGRARGRSPSPESDGAFGQPDSWNPTTHRSPPRGRIRFSNGIGRGRNLDDDTRRPQGSGKGPQNPNDYRRDYRERDQYFGNNTRQRSLSPIRPSTRQGNGASSWQPRARGGGNGGGGGSRGRGRGVKRGSNRETYRPMPSAAQKAWDQHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U302</accession>
    <name>A0A179U302_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_05393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01517">
        <property type="protein sequence ID" value="OAT01517"/>
        <property type="gene ID" value="BDCG_05393"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05393"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="324" mass="35756" checksum="000125D363D98FE6" modified="2016-09-07" version="1">MASPEPASPSPERSLPDAPPLTHQTTYKSFKRKYAKQKICFEHAMKKSNTLFKEELRIRDLSKRLKEQNDQLLEALLELNNSIRVPPELRYNLDLPGSKLPRLHSPEPEHYQQESYDTETAREALRVAKERLLAGEIKADQCRRLEESLLQSENFAPAVQYSSLLKVPHTTSSIHGDHPAMKCDMDSTLGFLSPEHETEYAAALDAASAGEPRPAGKSASAASRDREAAIRNPVSVINWLRKHQPSKRASTHTRKDEDIYDEDGILIDVPATGGGSGGGGGRGKRKRDEDGGYRPKGGSGGRSRKKKEDAPKRAKRSSAAGATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U308</accession>
    <name>A0A179U308_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_03596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00792">
        <property type="protein sequence ID" value="OAT00792"/>
        <property type="gene ID" value="BDCG_03596"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03596"/>
    <dbReference type="eggNOG" id="ENOG502R2TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMVYMKG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT00792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="312" mass="32252" checksum="F9700E536BACAC45" modified="2016-09-07" version="1">MDPAPNQLQAYPPPPGQGGYAPAPPNYNYPPPGGQPSPLAYPPPPTGGQTSPPPPQASPLPEKSPLGPGGAPPQGQFAGVQSTSADDVGTFNGGSYRISHRDSNTILTLQLAMGCPLSAKPGAMIAMSPTMTLKGSVKFSMKKLIAGGEMSTSTYTGPGELLLAPTLLGDITVLRLNGHDTWSVGKDAFLAATQGVVKDYKNQGLSKALFSGEGLFVYKMSGNGLLFMQSFGAIIKKDLADGEKYNVDNGHLVAWNCKYVMERIASGGIISGMSAGEGLVCKFTGPGTVYLQTRNPSAFAMWVTANATGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U311</accession>
    <name>A0A179U311_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01689">
        <property type="protein sequence ID" value="OAT01689"/>
        <property type="gene ID" value="BDCG_05824"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05824"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SSF50044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="716" mass="79234" checksum="E567F8DEDA4DAD41" modified="2016-09-07" version="1">MTRPQIIRADTVDLQGNRSQSTHDQTRQQDQLGSSDGNRTAPHQSLAMRNAEKEAREELVQSPRVSVDRSHADDSEDEMNGHDHGAHHDGIDHYSNGHSSADEGDITDGESDDQLDDDMLDKISSSPSIDDEDIDFEFVYALHTFVATVEGQANATKGDTMVLLDDSNSYWWLVRVVKDGSIGYLPAEHIETPTERLARLNKHRNIDLSATMLGDNAEKSKNPLKKAMRRRNAKTVTFTSSPVYHEPSDVEYSTEEEDDPDDQFFDNDDDEEILQSETNDGQEESHDEDIVVEPLRPKVQTDKDGSSAREVEPDRDPSPERVRANEDSFDRQDDNPTGRSRNGVVRNTDSFFKDDSLETKKISLTPNLLRDDSNNGPAATNDPKEVKGRGSLEAFDKVINSGDKTKDDKKRKEKKSGMLSGLFKRKDKKSKAIDDDMEESENISEESTRSATPPKTSSESSKEELAQQGLSNVATSTTSTANDGPGASVRAVPHDSQADVPQLLRVKEATREKPATSTSQDQISPNLDSPTTTTFLSTSISPVDSSQNPSSNARSNPSKETIRSTPIYEEEYEDMDSPIHISSPEHRNRNNPPDLTTDTSSVDETQNLALSPTPSSPELVEHPDDKVEENSAPTSSTNTPTWSEASLRSYLDDDTDIRDLLIIVHDKSNVTPAGPDHPITGSLFKEESKGLNEMSVRLDELLTGWMARKMKASVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U320</accession>
    <name>A0A179U320_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_07534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02466">
        <property type="protein sequence ID" value="OAT02466"/>
        <property type="gene ID" value="BDCG_07534"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07534"/>
    <dbReference type="eggNOG" id="ENOG502SZDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RPNWIFD"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT02466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="490" mass="56852" checksum="16A6162AF447AA5E" modified="2016-09-07" version="1">MDRYYYLPCPLCEHNVVISQTEHYRVLPLDRTQEAVMMKSPRWEPPHKIKVGDLCFIQGRSYPKISYLQRAWLLHKRCLEFVEQLSTTKLYHLLDLIEPTFLARSAPKTSVHGAFYYPQPKKDDPNYAEKVIPQSETTYIDQLMSFAKYLWMFIHGFLLRPLPGDRQTLFFQRLPEEIWDMILEHDIGRLLFVLETASQLTGKRDTPLIIPTERFTIKESKIRSPAIRIHCRNIGRRSYIHHVSNPTDSDTEGDNLVDYMLNDSKYLAIKSDGIGVVDISFEQRNGQPHWALDTPVRPFHAEISEIRATELQCLRIICDKCRAIIPSNRTGPEPFFSKTPFPPNNCWVDCGFSALELTPGNPFIHIAKATYIPFANLEKIALEVDTSRLGITEIRLDSKDERDHVVHFPQPPRQVKFQVCTVPLGFKYPYLQFEVNGQWLPQTPSGCTILREELVHNVIGMWWARTFPFIPIHIGFVVSQKTDLKNTLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3Q5</accession>
    <name>A0A179U3Q5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein intermediate chain, cytosolic, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002625368.1"/>
    <dbReference type="EnsemblFungi" id="OAT02684">
        <property type="protein sequence ID" value="OAT02684"/>
        <property type="gene ID" value="BDCG_08076"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08076"/>
    <dbReference type="eggNOG" id="KOG1587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="513"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="694" mass="76165" checksum="8F6F5A1247AFC9F0" modified="2016-09-07" version="1">MTMQQRKDEILAKKAKLAELRRQRELRQKEFSQNRQSIGEGGSEILAPTPGRSDSRAELNSLISRLVDRPSSAALRDGGESPRGRGSRPNSVLSAGQLSGEILESVTPPARPVSLSIATQTTPFPAAELPTPEAVPLPKPEVVTYSKGVQTDSWIEPRSRSVDGHSVSEDDSSPTTSRANKRLSRRQQRERDEEIRERLRKEIEEEVRSAKGMAGEGTAQQSTDIRYPLRTLTSDELNAVTSSNDFLDFVDKSSRVIERALDEQYDVLTDYALGGVGANGPDENDEYGNSKKRRGIEELVQFYDERWSKKRMISDINFSPKFPELVLASYTNNVTAPHDPNGIVQVWNLHLHSRPEYVFHSMSDILTAKFSPFHPNLIVGGSYSGQVLLWDTRSSRAGGGAPVQKTPLTGSGHTHPVYNISIVGTQNAHNIITASTDGVVCGWTVDMLSQPQEYLELTTPPPSKTEDLAPTTMTFPQSDPTFFLVGTEEGAIYPCHRYDRAGAKAGTDHRLSYRGHAAPVMSTVFHPARGAVDLGDLMLSSSLDWSVKLWRVRPPAVTSTSGTSATTPAQVVSPVLELNREDVVYDARWSPHRPGVFALVDGAGSVEVWDLCTDTEVYAARATPTKARNAVIEQSLNKVAWEERDGRRLATGGLDGVLTVFEVGKDLSGGPDEVPAEEWSAMKKLVAKLEQGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3R5</accession>
    <name>A0A179U3R5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenosine deaminase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_07304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02343">
        <property type="protein sequence ID" value="OAT02343"/>
        <property type="gene ID" value="BDCG_07304"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07304"/>
    <dbReference type="OMA" id="VPVVICN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="5">
        <location>
            <begin position="138"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT02343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="475" mass="53637" checksum="C6BE8B9646D1F539" modified="2016-09-07" version="1">MMFILAKARMESTKLWKIACRMPKGALLHCHMGAMVDLGWLYEKTLATPGMHFYSPLPLDTESNRSKAAVQFTYSKAAPKETASVWTSGYQPGTLIEANVAADSFPDGGREGFISWLKDRTSIIAKESIEHHLGVDAIWRKFTSAFIILGSIIYYEPILRAFIQKLLETIANDGVQWVELRDAFVDPYRRENEDVPSGDFNEMVRAIGEEIEKFKATKRGENFWGGRIIWTALRQMGTENIIKNMQNCIRAKKAHPHLIAGFDLVGQEDMGRTLKDLTPELLWFRQRCVEEKLEIPFFFHAGECLGDGDSTDDNLYDAILLGTRRIGHGFSLYKHPVLIDMVKEKKILIESCPISNEVLRLTATVLAHPLPALLARGVPASLSNDDPALLGQGTSGMSHDFWSALQGWENLGLAGLGSLAENSVRWGIYEDQTEEEWLRDIERGADGSGIRAEKMKCWQKSWERFCQWIVDEYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3T8</accession>
    <name>A0A179U3T8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01641">
        <property type="protein sequence ID" value="OAT01641"/>
        <property type="gene ID" value="BDCG_05713"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05713"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="422" mass="44789" checksum="453C70811D289D2B" modified="2016-09-07" version="1">MNTTSGSYALLGAELPEDSTVVVKLREAGVIILGMAGLSEWANFRSFNSSNGWSAYGGQVTGAYVPKQDPSGSSSGSGVASDLGLSFATLGTETSGSIVSPSGQNNIAGIKPTVGLTSRYLVVPISQHMDTIGPMARTVKDAAKLLQVIAGPDLNDNYTSAFPFDHVPNYVAACQRSSLKGKRIGLPTNVLEQVAPEILDNFNAAVKVMTDSGAIIVKDANYSALEESNTSPLPGEVISADFVNDIANYFSKLQTNPNNINTLSDLRDFTQAFPLEAYPDRNTGSWDGALALGYNNTSPEFWPKYQNALQLAGEGGVLGALRRNKLDAIVLPSSLASIGPGILGSPIVTVPMGAWPVGTEVVTTPRDLVLWAPGVPMGLSFLGDFWSEEALIGMAYAYEQKSLKRKTLSRYIEPKTELKDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3U4</accession>
    <name>A0A179U3U4_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_06161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01837">
        <property type="protein sequence ID" value="OAT01837"/>
        <property type="gene ID" value="BDCG_06161"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06161"/>
    <dbReference type="OMA" id="SHHQQWL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028367">
        <property type="entry name" value="CyclinC/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="PTHR10026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026:SF7">
        <property type="entry name" value="PTHR10026:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT01837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="238" mass="26567" checksum="E520AEE1BA4E8286" modified="2016-09-07" version="1">MTTRQQALATAQVYIRRFYTKVEIRRTNPYLVLTTAFYLACKMEECPQHIRFVVSEAKGLWPDFIVSDISKLGECEFWLISEMNSQLIVHHPYRTLSELQSTLSLTSDEVSLAWSVINDHYLTDLPLLQPPHVIAVTAILIAVVCKTSPASSAHLAGASPVSATLRDGAGALAALGDKNLPPRIQKLVDWLSTGEVSIEAVIECTQELVSLYEAWVQYSEKACREQIGRYVKARSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3U5</accession>
    <name>A0A179U3U5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VosA protein, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">VosA protein, variant 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">VosA protein, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_08155</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ER-3</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02713">
        <property type="protein sequence ID" value="OAT02713"/>
        <property type="gene ID" value="BDCG_08155"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02714">
        <property type="protein sequence ID" value="OAT02714"/>
        <property type="gene ID" value="BDCG_08155"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02715">
        <property type="protein sequence ID" value="OAT02715"/>
        <property type="gene ID" value="BDCG_08155"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08155"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="PTHR33572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT02713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT02714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT02715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="417" mass="45718" checksum="8957B8E7CD021B2C" modified="2016-09-07" version="1">MSAPTFPEDPVTQRPALQSADFRLTVRQNPERARVAGGKEKERKPVDPPPIIQLKIDETKDPGQNYLQSPFYFMCCTLYNATEDTPATTAQSTALAGTLVSSLHRLKDTDNMEGGFFVFGDLSVKIEGEFRLKFNLFEMREVKRCGGTRDEVVYIKSILSKPFTVSPPKNFPGMAESTWLSRSFADQGVKLRIRKEARTLLKRPMPRAEPEYPAPLAQPRSPERPGASSQQIGAAYQPSRDYPFYNGPEAKRSRSSVDMSGRGLYEGDARYQYQPHATNPYQNQAYQQGMMQGYTTAGTGVSDYPIRQAPQGSTPTPFGFADESMGSIRSPGAGGYMGQPRYQSYSGAQMPYNLSSSAQMSQMGESTPGRTGQAANMGGIVSGQSFSQPAGHMQSPSQVRQTGSAYPQGHSPESSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U431</accession>
    <name>A0A179U431_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02089">
        <property type="protein sequence ID" value="OAT02089"/>
        <property type="gene ID" value="BDCG_06739"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06739"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="Transcription_factor_dom_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal_trans" evidence="2">
        <location>
            <begin position="109"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="663" mass="75089" checksum="9AB6AA51FEAC709D" modified="2016-09-07" version="1">MNRSPVEISPPSSSNSGSFRPIWASGHSFSNIDADEYAEQTDSEILESLGYVAGSASSLAKEVLGTPPLDGFFYPPPGRNNTPNDPRRSQEAVLELFPDRKVVDFLIQYFLQEINWIYEMIYPPTFMERYTSWWLQQAYQESEDIQFGILVLRLCLCSIQLLPHPNYPHERAIQCSLNELETRCQNAASILDSFRPRYSSLTTIQHMFHYASYLTNESKFRETWIVLADIIKEAHILELHLEHPRIKVSDFEMEMRKRIFGTIYMWDRWMSILQGHWPLIPETYCCIKLPRDALPAAPSVPGAPTPFTNRIIQMRLMIMLSSRKTPEEQPRVPSPASASAIAESIETEIIATLPLPYSLSDYDGQFDNILPSIPLKRVGLRIAILGTLTTVHRPYTGMQHEPNFTNLSSVKEQKAAFKLQKKLIECTMDTIQSTMRFAEMLLGGCKKYFLLSLVALEASVVLSLCVRGLRRNRRAYIRLSRQGVQTFTENSELEGPTNAAFLEGLNFLNEMAHHSPIAAKGSQILRSLHQKLQRDATFGDPEHDIYSNISAPIQHQQEQHQQQQQHQRRAQQATTWVPAASTGMMTGAVLASEQLGNILAGPPVTTSTCSPEMVMDPYAWSQMASHTLPPPAEMHHYAHALPAANLSWYYDNGLVDRYATSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U434</accession>
    <name>A0A179U434_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromatin remodeling complex subunit, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02580">
        <property type="protein sequence ID" value="OAT02580"/>
        <property type="gene ID" value="BDCG_07806"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07806"/>
    <dbReference type="eggNOG" id="ENOG502S6SH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="2">
        <location>
            <begin position="463"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="734" mass="82487" checksum="583BD97813A7CBA2" modified="2016-09-07" version="1">MNGPVAADGSPADARAARGLRRAPPQRQPYTATGPATRQTRSGGNPPGTPANLNNSLPSTLSYSPSSTPATTATNNNTTATMSFTTHSPYMDNRTPMHTIVVDTPSNRRGRYSQVDQPPLPRTMDPMMVSMIPEKTPRIYNHCVKGLQSRIPSEVDFALHHLVVISDERGDKFKFDDFPFLAEELVEKIMEITYLVSGIRWEVDYTSLEAPRDNLLYGTGNTDILEKMAKFPITLGGDNVETEEFAHHLRNIKEAALTLRNMSMLETNAVFLSTLEIFKDGMLVVLNSPRQPRFNEILNYALDTIEQVCPYWETDPGDPLFNTLFELLGSSDRYHILTALKIMILYSMELETIKRLQGVPDDKVSMLMSYTLLEQDKELLSGTLDFFYQYTAIPENVEDLLSNFSLPTTLIPRLTNLLLFEGERDINEIVDQEECKAPATTTIPIVPPDLHAMLLRLPEPERCSRWLKCCFIEDPECDITQLALWHAYQNCFADERVPGVSTLPAAEFINTVSRTFSTAQAQVVPGAVAKFIIRGIRPLETSYDFNGYPYHQCKWNGPSGQCRVAFIDPAKLKDHVFREHMLLNPADLGNLQDAHRPTNVCAWETCGEFQIPTINTARVAGHVSTHLPPLMDMSSPPPPPSRKIIQPKLTRMFDYYPTPVDEKGDPVGIAYKAILILRNIIRNLPKESAGPKHGNKSWNYVLFFSSKNKLIEIADYNPTLRGDIFEFVAEIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U442</accession>
    <name>A0A179U442_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="7 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDCG_05935</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Endoplasmic reticulum membrane</location>
            <topology evidence="4 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="7 15"/>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01741">
        <property type="protein sequence ID" value="OAT01741"/>
        <property type="gene ID" value="BDCG_05935"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05935"/>
    <dbReference type="OMA" id="TLSVKWV"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027004">
        <property type="entry name" value="PMT1/PTM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="PTHR10050:SF50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="SSF82109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="341"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="416"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="485"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="790"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAT01741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="823" mass="93309" checksum="A9C4A37DB36AAB20" modified="2016-09-07" version="1">MASKSAKGGLEVKPHTRNGRSPSRSPGPKNRKKAVASKKLDYSSEGVSDYDILQLPVSDYKIMLMLTAIAVVVRLFRIYQPTSVVFDEVHFGGFATKYIKGKFFMDVHPPLAKMLIALVGYLAGFRGDFDFKEIGKDYLEPRVPYVAMRMLPAILGIMSIPTMFLTLKAYGCRTSTASMGALLVTFENGLVTQSRFILLDSPLVIFTALTVLAFTNFTNQHEQGPSRAFGASWWFWLTLTGIFLGATVSVKWVGLFTIAWVGSLTIVQLWVLLGDTRTVTIRVWFKHFFARAFCLIVIPVGFYMSMFAIHFLCLANPGDGDGFMSSEFQATLNSKAMQDVPADVAFGSRVSIRHYNTQGGYLHSHSSMYPGGSKQQQITLYPHKDENNIWVVENQTQPLGEYGEVEGPSAWDNLTAGHVIDGSVIKLYHTSTHRRLHSHDIRPPVTEADWQNEVSAYGYEGFPGDANDLFRVEIVKSMSDGPEAKKRIRTIQTKFKLIHLMTGCALFSHKVKLPEWGFEQQEVTCAKGGTLPNSIWYVEQNDHPMLGPDAEKVNYRNPGFLGKFWELHKVMWRTNAGLVESHAWDSRPPSWPTLLRGINFWSRDHRQIYLLGNPLVWWSSTAAIITYVIFKAIATLRWQRSYQDYKSIVFKRFDYEIGQTVLGWAFHYFPFYLMARQLFLHHYFPSLYFAILAFCQVVDYGVNRVSLSGAVKSKRVFGKIFMVAFVVLSIVTFTMISPLAYGNPWTKAACQKVKLLKSWDFDCNLFHNDLAQYETPMKFVNGTAQLLHATPTPVPQQPQQQQQEQQQKVAKLAEEGDMKPRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U445</accession>
    <name>A0A179U445_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-glucosidase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_06768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02099">
        <property type="protein sequence ID" value="OAT02099"/>
        <property type="gene ID" value="BDCG_06768"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06768"/>
    <dbReference type="OMA" id="VMCSYQM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
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            <end position="834"/>
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            <begin position="732"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="843" mass="91282" checksum="067C84042403C6DB" modified="2016-09-07" version="1">MLSRSGPASSVGFPSLCLQDGPLGIRFADNISAFPAGVTVGATWSRDLMYKRGFALGKEARLKGVNILLGPAMGPIGVLPAGGRNWEGFGSDPVLQGVAAAETIRGVQDNGVMATAKHYVLNEQEHFRQEGEWGIPIAMSSNIDDRSLREVYVWPFAESVRAGVASVMCAYQMVNNSYACQNSLILNGILKDELGFQGFVQSDWLAQRSGVASALAGLDVSMPGDGLGWADGISLWGHHLTQAVLNTSVPMDRLNDMATRVVASWYQLKQDSWAKPPPDGDGGPNFSSWTHDRIGRLHQGSPDDDAKGVVNQYINVQGEGDDAHGPLAREIAAEGTILLKNENGFLPLSRDGPGLSDEKYRIGIYGEDAGAGEGPNACADRACNQGTLASGWGSGAVDFPYLITPWKALSRAFNNKSTTVSGYLTNDRTPPEDMRDKDLCLVFANADSGEGFASWKDIRGDRNDLILQKGTDSLVSQVATECGAGNGSTVVVIHSVGPVIVESWIDLPGVKAVLLANLPGEESGNALADILFGDVDASGRLPYTMGKNLTDYGPEAGILYKSDDVIPQKDFSHGLYIDYRYFDAHNLTPRYEFGYGLSYTTFNLSNLILRPLKSKTPLPSPRPKENSPPWYNTTIPNVECALFPEKFRVLTKYIYPYLSSVDDIKREPPYEYPKGYDEAQPPSPAGGGEGGNPSLFEPFVTVNVTVSNTGTRVGKEVVQVYVSFPENVLDEPILDNNSSSSSNSNNNNSSDSSSISNSPNNNSTTTNPSHNSTRTVDFPLRVLRNFNKVEVQPGQNVTVSLPLTRKDLSYWSAVNQNWVMPVSGKFQVWVGRSSRDLPLMAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4A4</accession>
    <name>A0A179U4A4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDCG_04837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04837"/>
    <dbReference type="Proteomes" id="UP000002039">
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="243" mass="27117" checksum="28755D87D3EA38DC" modified="2016-09-07" version="1">MPLLTLHLLSLTPNTDPRSFVKELKKSPGVEVVVFSRPRHVVVRSNILDGNPLQTTKWDLLVLLRSPQNSIPAPLRAAYIITTSVPITGSLDAARGKPSSQNLELSPDLLGFMDELLKTHDKPVTMLNLLHFHRGGKPEYYKYGQGFVKVAGRIGGDAKLVGNVVKPAAGLRDSRGDPDRPEGDWWNEIAIVHYPSIRHFCDMLASDEYQDINSKHRLNALRDTFLLCTTEFDVEDDELSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4A7</accession>
    <name>A0A179U4A7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDCG_08467</name>
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    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Ajellomycetaceae</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08467"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="135"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="362" mass="38976" checksum="ADB57B56544268B6" modified="2016-09-07" version="1">MASSEVDQKFLGFFAASTARENAYLSGMLYKLLGLSVVLSKKLLRARKLRRLDPTRETKSLQLYHHILWLSREGLVITEQYVLPMAEAYVELKVLAHKLRASFYHIFVLFHNQPSIHLSGIRSLPPSGSQLHLPNGASGMENGNGVKRGSKLSPNANRDSIAASPPPIIPEGGPVGGTHLHPPGLPAVRPTKIAASFILPALDYTPMATACFSDVAQLADNLLPGSHPVRLSVKLEYAAYLYDCLHDSDGCRRLAKQAIADVYNAQEGMDDESFEDAAELVGILGKMVKRGGKTSSAGGSSTPGGGSTPGTQQDSSGAARQRHHYQQQYQPRTPTTRGTPTKVLTSNAHAPAIPTPTMTNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4B3</accession>
    <name>A0A179U4B3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02169">
        <property type="protein sequence ID" value="OAT02169"/>
        <property type="gene ID" value="BDCG_06906"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06906"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1356" mass="145908" checksum="07A2F711099A189A" modified="2016-09-07" version="1">MFQNKQFSQPNQTQVKHAVHDNMVTAPWTGQGVQQVNHQTPHNGYHQVPQPHVEANGRPVHPGVSPQQHAFANQVNVMPGTEFQNGNTVMAPIPHAAGPNHAQTHTRAHHHFQNNNTYMQSFQPMDPEYEVQQPPLNSSVQPMNPGYGVQQSPLNNNIQPMNPGYGMQQQALNSNIQPMNPEYEVQQPPLNSSVQPMNPGYGVQQSPLNNNIQPMNPGYGMQQQALNSNIQPMNPEYEVQQPPLNSSVQPMNPGYGVQPPAPNGNGPVSNNNHGNGSGSSPNRQMSGTHRNEAFNVPSQNGQSNTMMAHQNGVSHSLDGVTFGVPPQMQGTHHNEFFSVSNQIGQNNNMIANQNGVAQPPHEVNPGNSPHNQGSQQGSPFRGPNHLGQNNTAVAHHQMNPRAPSYIPGTHHNEPFHEPNHRGHGNVGPPQNRTIQPFPGMNPEHLPPHSSQPHPSAPHHPVPDGLNVPPHSEFNGVQQTNVGHPNPESNDMHPGIHHPNQGVLAGSFEGNQTGAVITHPHGPPQTYQQDAPAPNPGFVNPTIPGYQPDVHAWPNNSHAPAPVAQAPNRFSDPGTVHRNPSNAGFTMPPSSNGMGTGVQAPNAMGQNTPPNANPPFPQDGQFNHPSNGGTQPANDQNIENMGNPNGFHTGSQGFPNGMAYHPVPAPQPSDSNAAQHMNQNNRSFQNGVVHHPASAPQPSNSYAAQHMHQNNHGFQNGVVHDPVPQRSNSYAAQHMNQNNHSFQNGVVHHPVPAPQPSDSNAAQHMNQNNRSFQNGVVHHPVPAPQPSDSNATQHMNQNNRSFQNGVVHHPAPAPQPSNSYAAQHMHQNNHDFQNGVVHDPVPQRSNSYAAQHMDQNNQGFQNGNHGFQNGVIHDPAPGAQPNGNSHAAHAGRPYTGQHANIEAGSNRVTRKAGEGEATGQYPALAPVPTVALNRQVYAQRFEQRPAQYHNLESRQIQNSQIGHGVGAPPQPYVIQAPIRRHTIPIDPCVRMWRLKRDNRGNSTRGVRRRAQPGQPRATRRSTGTTSNQPPSHSQSNGEGGLAPIPPSISQPTPEQGTQSGGAPRVQPISQPNGHPTVPTSAETPAGVHPAPQENGYPAPYANDNRENRENIYPAELQCGNGGVSPDPAVFQEPANPTRGQRIDWAPPSVPAASANGMETAPTQNGNPENAALGGLPDEAQFDTSVGSWFTEFYDPRCIDDQSDVGQRYAEQMDHTNTPGDLGQIPASTRLSPTQLNAGQLTAEDFDESMQMIEPIGHDNTPGYPVQLPSLAGSSSSAQPSNVGQPGQEEMEVDNGNTPGGPAQIPSPTGSSSAQPNASQFRAEDFEETMAMMRDDDDDDGNPVQSSNDESCGSRNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4B4</accession>
    <name>A0A179U4B4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01312">
        <property type="protein sequence ID" value="OAT01312"/>
        <property type="gene ID" value="BDCG_04868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04868"/>
    <dbReference type="OMA" id="TFENCWF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="722" mass="80936" checksum="348AA2F632461308" modified="2016-09-07" version="1">MAKGWPPYGIPVELFACVAAYLSRQDICNLRLVNKECAFKLQRVLFRTAVVPFGPMIYSSDEASDEKIDLFETLGGCVSRFGLSFELDQIQLFDPPEKVYNNTVKTFWGEYEWPKPDYVEYDYLRRVEEVGDQAERMKRAFRTLTNVSEFALSFDTGYGWLNPPTLVDDSLEFEGKRSVFCGQAVASAPRNKRVASISSQSLKEYLESILPEWASKSLYRLKDAINEDYLDSPRLSFPRSRRLPIDPTIERGKTYGEHRAIGDCGLYPRNPTRAQTEWLLETSWAAQATLGSCIYAVIDAKSTFQRVHTLNISSISSGLLGNLNQPRFFEAFPCLTTIILLVIPDWKESDMTWDSQSPIKYIAPSAASTLLTRLLENVISHLVQLKRLTVGYIGGGEHAKGEYCRNQHILPAPITYFAQDAANGRLPEPPLKFPHIKTLTFKNCWFSPILLIQFFKSACHSSLECLKFDSCSLTAVPGTLPRPYVSNKVRPSCTRDEYYLQELREGTWSDIINQFTPALSLSEQMASMGLKDSPPPREDVPPCLRQLEFYPVLSGPAPVPPAVAQHTQQTNQQADDPAVSLQPTQQVQADTQHQNATMAALPPGPIAHEMHVPAPQIPETGFEEASERRSYIDCRLNGTIVQCIGSDEEQVLECAFGLTMGWGSWDDIEKRREVVSDGFKQGGAGRFSGVIVGSDRGFTERRYSAGPGCYRDVPGLWDSFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4B6</accession>
    <name>A0A179U4B6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02047">
        <property type="protein sequence ID" value="OAT02047"/>
        <property type="gene ID" value="BDCG_06630"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06630"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="223" mass="25048" checksum="11DBEED9DF05C234" modified="2016-09-07" version="1">MYSTYMTRAFDKFAMLPRVLTLNDYFLDTGYNITAFHTIQINPGEAHQGLHHDDSFCHVPRPRMPLGSAIILAFDEFTAENGATRIIPGSHTWGADRRPKYDETVPMTCPPGSVVYFLATTWHCGGPNNSLNPRKSATVQYCQPYVRPIENQILAVDPRRLTEIPRRIVEMMGYQIHAPFIGYADGLNPITAVRRMVNWLQGPLDPNPPTFASKAEISGNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4S3</accession>
    <name>A0A179U4S3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_07246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02328">
        <property type="protein sequence ID" value="OAT02328"/>
        <property type="gene ID" value="BDCG_07246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07246"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT02328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="144" mass="16247" checksum="E65286AAD4B4AB4E" modified="2016-09-07" version="1">MQFPTSILKQLSNFTTRRACIYRSLHTKLAEFITLDYKGSLVTQNVNVDLGHAHEAFTMLPKEIGYAFRAGIHSLARDSDQCPLTFYHDSRYFAHESLPYPRLVIPQDLPRQSDANTSPATLHTFGATHTITLDGTFDASRFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4T4</accession>
    <name>A0A179U4T4_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_08951</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT03016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03016">
        <property type="protein sequence ID" value="OAT03016"/>
        <property type="gene ID" value="BDCG_08951"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08951"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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            <begin position="21"/>
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        </location>
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            <begin position="33"/>
            <end position="383"/>
        </location>
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        <location>
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        </location>
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        <location>
            <position position="250"/>
        </location>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="141"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
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            <name>substrate</name>
        </ligand>
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        <location>
            <position position="182"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
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        <location>
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        <ligand>
            <name>Ca(2+)</name>
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            <position position="311"/>
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        <location>
            <begin position="50"/>
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            <begin position="170"/>
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        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAT03016.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
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    <sequence length="490" mass="54175" checksum="FEB23C79BE8CA6D4" modified="2016-09-07" version="1">MKFSTSGLGAILALSEAVTAATPAEWRSQSIYFLLTDRFARTDSSTTAPCNTEDRRYCGGTWHGIINKLDYIQNMGFSAIWITPVTKQFPEKSGYGEAFHGYWQQDIYNVEPHYGSADDLRALSAALHDRGMYLMVDVVPNHMGYAGPSSSMDYSRFVPFNSKGYFHAYCPITNYDDQANVENCWLGDNTVSLPDLDTGNPEVQNIFNNWISALVSNYSIDGLRIDTVKHVPKPFWRKFNDAAGVYSMGEVYSGDSGYTCHYQNYLDGYYALLEVFKSPGGNIANLYNMINTMKDSCADSTLLGTFAENHDTPRFASYTKDMSLAKNALVFTILADGIPIVYAGQEQHYAGRKDPDNREATWLSGYNTESPLYQLTAKANKIRKKAIADDPNYLTYKNYPIYQDKSTIAMRKGFDGKQIITVLSNLGSGGASYTLQLGGTGYPAGMRVTDIYTCTTAVVGSNGQVPVSMAAGEPRILYPSERLVESGICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4W4</accession>
    <name>A0A179U4W4_AJEDR</name>
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        <submittedName>
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        </submittedName>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="gene ID" value="BDCG_08170"/>
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        </source>
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    </evidence>
    <sequence length="968" mass="105940" checksum="FC1A9A3B792C0C36" modified="2016-09-07" version="1">MFWRFGGYANISAIDTLLEKPDVSLEEVLDESELMQELKQHNTKLIEYLRDDNVLKRLLDYVISPSLIDDEDDHDDGAQEEKERDREGESAEGQEAAVTADSSEKAKEEGQEHADDNPTRLSSGLDIEELENAEKSRLKYCYIACEILSSNSWSIIESMMLNEGYLRDFWRFLWREAPLDPLQSGYFTKVNEVLLEKKTEEMLAFIKSLDGVVPTLLRHVDNPMIMDLLLKIISLERMEGGQGVVEWLQSQDLIPSLLSCLSTEHTSSTQTSAGDFLKAIITISANAAQNDQSCIGPNSLTRQLVSQPCVEVLISSMLKGGNPLTVGVGIVIEVIRKNNSDYDPENAGGPDSPPTIHDPIYLGTLLRMFAKNVPGFMNLILSSQHTVNEGGQHKVVERPRLDSAWGTSIEPLGFDRFKTCELMAELLHCSNMGLLNEIGSDEYIRKRDAERERLRAQGVFTHGEDDSGFEYADNTNEFANGISPSALGSGSPEDIKRLDASQAGEEDGFEDVASSGVLIDDVKDDFDEKAEGENNAKAGPEPFTSIPPHAPKLGISDDFVDEPLTPPEQGTSLDAKVIQPLSPSQANDPLSPTASILTQKVESFKIDAEQQHSPNEKHASSPRTEVPTLGLPEGQLSEKQGGSQGDHELDSLLSPHLEDTPAPLFAAKDSPPKGETQPPGQEGTDGKVETSTTFDNSGVTSSLTPSITMGDAGENVAHPHIQIDTDGQPVVGDYLKIMFVEHKVIPTILSFFFRFAWNNFLHNVVYDVVQQVFNGPMDRGFNRSLAIDLFESGHITEQIVQGQRRSDEAQRTKNMRLGYMGHLTLIAEEVVKFSERHPPELLSATVMENVLHPDWIDYVERTLSETRERDNAILGGVRPDMSIGHRQAVLNAVNASQGFTASTALANAGLNGGAPGATFEGLDIVNQGSASGGAFFGGIGGPSLLSGFGSSSDDEDEEMEDPEYEDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U550</accession>
    <name>A0A179U550_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAMKK/CAMKK-META protein kinase, variant</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">BDCG_09219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03125">
        <property type="protein sequence ID" value="OAT03125"/>
        <property type="gene ID" value="BDCG_09219"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09219"/>
    <dbReference type="OMA" id="VEPPMEM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="58"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="666"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT03125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="763" mass="83619" checksum="854A4C8B8B2DADEB" modified="2016-09-07" version="1">MAVFSGYDRSTTASHDSPLRHQTRSRTAPRRVKETLNARSEYTNSQDDGTAEHRINQYLIKQEIGRGSFGAVHLAVDQYGQEYAVKEFSKSRLRKRAQSHVLRNPRGVRRPGIIPAGMGLNSPLHRHPSGHEDEEGSNSLYLIKEEIAIMKKLNHPNLVALYEVLDDPTEDSLYMVMEMCKKGVIMKVGLGECSDPYPNESCRCWFRDLILGVEYLHAQNIVHRDIKPDNCLLTNDDVLKVVDFGVSEMFQKDSDMYTAKSAGSPAFLPPELCVAKHGDISGTAADIWSMGVTLYCLRYGRIPFEKESIFELYESIRNDEVKYENETDEDFIALMTNILEKDPAKRIKMPELRNHPWVTKGGTDPLLSTEENTANPIGEPTEEELNTAITKKIGNVLTVVRAVQKFKRLIEPENAPMQSILGQDVEAHFVQPPLSMEASYVEVSSANTTDQNAPSSAKSIHSKSGSTDSKRRVIEKGIYVPPAVHKSGSASRLGCTHGESCRYSAASISKSPSPPLQTSRTSTPSKQSFSEGTRGHARDPLEEDNSFLFIGPSTFTGVLTVDDEKTSLTYFSRAATSEPMGNSEVTSGLGGHGFPIDEMGLVPIVSESPGASGIDIYETAYMEEVERIRKQSLARQKPAPKVYLTRRVEGKESSLGELLRQATIGMASTSPAEDQKAPSTTTTTTVQIEQSTEGSGQQVTQAAAAATLAPTSSTQPPPHKALGAADAVTNMTNATAETVTTSTTQRSRTGVRSLLGRVRRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U559</accession>
    <name>A0A179U559_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Triacylglycerol lipase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02347">
        <property type="protein sequence ID" value="OAT02347"/>
        <property type="gene ID" value="BDCG_07311"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07311"/>
    <dbReference type="OMA" id="WFGCKDE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107194" evidence="2">
        <location>
            <begin position="39"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase_3" evidence="3">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="623" mass="67621" checksum="8116BA2616C17D4A" modified="2016-09-07" version="1">MQPSRWKRKKRSSGSTLMGFDVLVSLLAISPLPSIVSAQNPFIQPQIPLPGPQPVDTDHEFSLRHIFHHGTYRYPLLHKRLDIKPDAELWVASEDGEGREPVPRLRASSRAVNIQRLADRRVSVIEDHLLTARLTSSPVALSSDYWTLDEVDAPDVTDKETVLSLARMAANAYIMLPGTEQWADVDSRYNHSDSFGWESDGLRGHIYADKSNSTIIVALKGTSAALFDGEETTTNDKVNDNLFFSCCCAQGGQYFWRQVCDCYTSTYTCNATCVRKALRAENRYYRAALDLYANVTEIYPNSNIWLAGHSLGGSVSSMLGMTYGLPVVTFEAVPEALPASRLGLPSPPGIDPSSPQKRNYTGAYHFGHTADPVYMGTCNGATSVCTLGGYAMQTFCHTGQLCTYDTVEDLGWRVGIGTHRIRSVIADVIEKYDTVPECAPFTECVDCNNWKFFESNGTEPTSTSTRISTATRTRSSTCKTPGWWGCLDPTTTATTTATTSTAITTTSTCKTPGWFGCKDPTTTSTVPTASPAPTITPTSPPTTTASTTSSCETPGWFGCKDPTSTTSSPDPTTTPTTTSSCETPGWFWGCYDSTTTESPSHPITSSPETTSPSATSSPSGHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U576</accession>
    <name>A0A179U576_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cupin domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_05682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01632">
        <property type="protein sequence ID" value="OAT01632"/>
        <property type="gene ID" value="BDCG_05682"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05682"/>
    <dbReference type="OMA" id="KMHMVFY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="PTHR16684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2_N" evidence="5">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-C_C" evidence="4">
        <location>
            <begin position="489"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT01632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="612" mass="67669" checksum="0C1161539FA6D44A" modified="2016-09-07" version="1">MPPRGLAKARDFDYSNVGKAGRRTGITLKEGKLDEHGMEEIEGMFSSPEKSPVRTNGHGYGNDTLNSEDMETGDSRRVQRNPLLLPPRSRSPMKSNMSGSPRRTPGIRSSSVAHYGPSSSPISARPSAKRALDFSHAPRLARSPPDMPLEADEPADFSDDGNHLMDDEAEDTHFAESHGDYHEGYDNVDGDSPNPQNQDDDDDENDAPVEDPEDPEDTGSEPSPSIIAKTVGRKRKNAQSKPKSSTRTQQEREADSEPAPNASAKPAPKRRGRKPKAATTEVDHDVEEDADGSRAPKRAKTSGSKGRSNLHMSVEQEQELNSVVENITNRNGPLKNRSLYILKRETPSDQSARHTRSGRVSVRPLAYWRNERCVYGDGSAEVGQRFPLSTIKEIIRTEELDTRVDRKGKQSSKKKSKSKSKSKRSKDDPSDDEDEIDNAEPWETEEGVFYGPVKKWDPKTQSATQEEEMIDVAFAPSAIETHEVKDSTFRFAKILNNVFLGSGFVDMPPGAVKRQKNSKKMHMVFFVYHGRIRVDVSGLQFSAGKGCVFQVPRGNNYSFANDYDKPAALFFTQGCVPQNKEGESESAEPTSVPVEAPVQAPAGAKRGRPRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5C5</accession>
    <name>A0A179U5C5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_09417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999987">
        <property type="protein sequence ID" value="OAT03206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03206">
        <property type="protein sequence ID" value="OAT03206"/>
        <property type="gene ID" value="BDCG_09417"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09417"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT03206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="275" mass="31312" checksum="861E7C31452CB84E" modified="2016-09-07" version="1">MSLRGTPARIGEVFNARYQVIGKLGYGATSTVWLARDMNCSLDSLHSKCKIIHYDIKSDNIMLGIADDSVFAHFEESELQTPSPRKELDDGRIICESRQLRMPKNFAPPVLCDFGLAMPGDIDEHLEDIQPNFYRAPEVILQIPWSYSVDIWNAGCVAWDMFEGEFLFTGHDPELQIYRSRAHLAEMIALLGPTPPSLLAQGRLTSKFFSEKGEFCAGIPLQHPVSLEERETTLKEQPEDREKFLCLMRKMVQWEPGKRSSAEELVQDEWIHAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5D6</accession>
    <name>A0A179U5D6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Choline dehydrogenase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01702">
        <property type="protein sequence ID" value="OAT01702"/>
        <property type="gene ID" value="BDCG_05855"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05855"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="532" mass="58285" checksum="43D24EFA284DFB05" modified="2016-09-07" version="1">MFDIRTAPEPGLEGNTYAVRAGSVAGGGSTVNGMAYDRASVADYDSWEELGNRGWGWKGMFPYFRKSADFTPPPKAIVDKYQYTYDETAYGHFSPLQVTLPHWQAPDQYKMADAFTELGVEHLQEHAKGNAIGQFWAPATIDAKTMTRSSSLTAYYDKASWRPNLKMLTKHQVTQLTFDGDSTTVTGVKAINRKTNAEVTFRARKEVVMAAGALHTPQILQLSGIGPKSVVEAAGIKSRVDLPAVGSNLQDHPVAYLNWKVTNSFPEPNIMAINETFAAAALEEYQNHRTGPYTKCQSNTIAFLSLSMITNNTEDLINDLKSQVASNYLPDSYTSDLIAGYEAQRTILARQLGDGSVSALEFPFSGSGMVPNSIQKPLSRGTVYLNPTNPHGEPIVTYHAFTNPFDRAQIATFIKFTRRYFKTNALADMQPQEVSPGEDAQTEDQIIAKLIAGGPLSLSPSFAHPSSSCPMMPKEKGGCVGADLQVYGTKRLSIIDASIIPIIPSAHLQATMYAIAEKASDIIKWRGLWQWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5W3</accession>
    <name>A0A179U5W3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose repression regulatory protein TUP1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_09151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002620234.1"/>
    <dbReference type="EnsemblFungi" id="OAT03103">
        <property type="protein sequence ID" value="OAT03103"/>
        <property type="gene ID" value="BDCG_09151"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09151"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYYILYN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Tup_N" evidence="6">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="507"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="549"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT03103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="584" mass="63487" checksum="D5604D82629D943C" modified="2016-09-07" version="1">MYNPHRGMVAAPNSRLTELLDQLRQEYENQSRSTGEFEHQLTGQLQEMEMIRQKVYQLEQAQIKMKQEYEAEIRTLRRELESRGVHLPQSHIGGPPTHAGPSQAPPPALGHGPANLFGGIMANPGGGAPALAPPPPQDQQQPPQHALQQPGSAPQGPPQPQQGAFGGYQPASAVNGYGPPPPPTSSPGPGKGRANRAPPGPATPQQNHQVAYPDPRASPQIPRPTPTSQQLSYRVGNTLADLDPDKLPPSQKKEGADWYAVFNPEVPRVLDVDLVHHLVHDSVVCCVRFSNDGKYVATGCNHSAQIFDVATGQLVTALQDESVLDKDGDLYIRSVCFSPDGRYLATGAEDKQIRVWDIANRTIKHIFSGHEQDIYSLDFARNGRYIASGSGDKTVRLWDIVDGKQELILSIEDGVTTVAISPDGRFVAAGSLDKSVRVWDTTTGYLVERLENPDGHMDSVYSVAFAPNGRDLVSGSLDKTIKMWELTPPRGMVPGAGPKGGKCVRTFEGHKDFVLSVCLTPDGRWVMSGSKDRGVQFWDPATGNAQMMLQGHKNSVISVAPSPTGNLFATGSGDMRARIWRLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U668</accession>
    <name>A0A179U668_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sphingosine kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002629018.1"/>
    <dbReference type="EnsemblFungi" id="OAT02818">
        <property type="protein sequence ID" value="OAT02818"/>
        <property type="gene ID" value="BDCG_08419"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08419"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AECDLGT"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017050">
        <property type="term" value="F:D-erythro-sphingosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="126"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="495" mass="54314" checksum="F3A2C10B6F60F7B0" modified="2016-09-07" version="1">MTIGAPVLDAGPSGNKGTQSVVEDVLHPNSDSSATLEVGKTALLTLAADAIIVTESSGTLTTRSIPYTNILWAEVSHDYITIEYAHQVTNTDVALRSVYFPVSLEQKSKAETWTEKLLDLAYGKAQRQKRIKVLINPFGGKGRAAKYYYKHVKPIFAAAKCRVDAELTNYRGHAVDIVEKLDVDAYDVIATCSGDGIPYEVFNGLAKKPNASEALRKIAVANLPCGSGNAMSWNLNGTGSASLAALWIVKGLRTPLDLVSITQGDKRTVSFLSQSFGIVAESDLGTENIRWMGQARFTYGFLVRLFGKTVYPCDLAVKVELDNKEQIKDHYRAGSERKSFEQLRGEESSDCVGLPPLRYGTVNDPLPEGWTLVPHDKLGNFYAGNMAYMAADANFFPTALPNDGCMDLITINGDISRRTALQMLMAVDNGTLFDMPEVNVRKVTAYRIIPRDRKDGYISIDGERVPFEPFQAEVHRGLGTVLSRSGYRYETIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U669</accession>
    <name>A0A179U669_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_09439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ER-3</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999987">
        <property type="protein sequence ID" value="OAT03212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999987">
        <property type="protein sequence ID" value="OAT03213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03212">
        <property type="protein sequence ID" value="OAT03212"/>
        <property type="gene ID" value="BDCG_09439"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03213">
        <property type="protein sequence ID" value="OAT03213"/>
        <property type="gene ID" value="BDCG_09439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09439"/>
    <dbReference type="eggNOG" id="ENOG502SGJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PICRTAG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT03213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="180" mass="19843" checksum="CEB4029DC649E904" modified="2016-09-07" version="1">MDGGQKYIPREKLQALTTQITYQGVCGIPSAPFYKGDTYAFKFTVDCPLALCNLPTGKAVDHGAENQFLQSVMAVYNEEIFSARRWICQVCGKPAKVLYHGMVPFLCSELGPSSDFQPSVWDSVVPICTTAGECDFQAEEVAKQSFRDVLPKAITCSQYGCESCGIVKNVKRCAGCKRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U678</accession>
    <name>A0A179U678_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_09468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999987">
        <property type="protein sequence ID" value="OAT03223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03223">
        <property type="protein sequence ID" value="OAT03223"/>
        <property type="gene ID" value="BDCG_09468"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09468"/>
    <dbReference type="eggNOG" id="ENOG502SQ6T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QYWANQL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="SSF57701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT03223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="526" mass="58722" checksum="733C5265FBEB3A3D" modified="2016-09-07" version="1">MKKSQKRRSRSGCTECRRRHRKCDETRPSCSSCRITGRECSYEVRLSWGGRPFRKSRFGDCLSQDPSLTRVPVSTSSDFSGRAFVYGSGCESSGQLSHPKATILTHSAGNQIIRNPDLLSWLHPTYRSLLDHFISSTTRALSCHKVVQQDFCAVLVPMALQTPYLLVALLSLAATHRVSLGIEQNLTELDLLSTTSLNQLQNVLSQPNFHLDDATIATTLTLCFTEIVSDGRSPGSWRLHLQGAAAMISEHLKTVKVPLDSLPSATSLLWRWYFSMETVSLLCGNLSVPPSSRAGLLIQDIFEHDEIDDLAGFPSSLVPIFKNINRLTMESGYTQNQPGNINATSTTQPSQPSNSIIDRCHQIINEINIMLLTAKVPRFRPNVDSTLTSVHRSDFTALDETYHHAALLQLYRRVLNLPSSNLLVQSSVGQIIRRISSMHFLDEACPGVAVLQPLFSAGCEAYQEADRENIRILLCRMGLRYGMGNVRSALGFLEDLWYMRDANSDSEGRVRWDKVMVEKGLDLLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U681</accession>
    <name>A0A179U681_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02002">
        <property type="protein sequence ID" value="OAT02002"/>
        <property type="gene ID" value="BDCG_06522"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06522"/>
    <dbReference type="OMA" id="REGWTQV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="687" mass="76801" checksum="52847FF9746E6DC7" modified="2016-09-07" version="1">MLAVRSPASVSSGNQISAFSPYSASPSSPTPYSMQSDRPPSTQRSPSPSQMSSNSKTTEFSRSSPKAFTPNGLDPSDNQDGITNGDMERSITRTGSALSIRTSGAGVSDFKPSSDEDDAPQSVIHVPSGFGKFLDNVPSPRAEPSRSSSALSDVTVTSPLAGQNDNDNINNNKPTTPVSPPPITTTHIAPPEHWSDRTTPRAQTRQEVEDFKKRARKSNLEDIPETFDVEQAAEDTEDEPETLRDMGEITTTSVGKFEAREHELKALRTALSECWTLCNTLASLSYIHRERLFNFSGKGDMQEQAWKSCWKLCQNLYENRDNDDHHTYVRPTLDLCRDFCQALFEVRVRDNEVTDSVLRVSFELNNHLYNTHDRNLPEAFRHRTLDFYITLCHRLMKQRTRLAKETDTLLKACWSLAEMLFSLRQRRREGKSPDEELLGSAIQACWELCDLFRQGWTQIRPDRGTPRPSQTTFTQAFYQAKRSEYNIMSDEDTQSRGGNPETPTTIFEDTATVSPEEAHVPNILLLNPSNNQVTPPKWSSNSSTLSGYSQSSSGKTASSNNTVKSPAEDPNLTCLKLLIIRAAMNSGFQRGTTQTLSAFVKSLSSDSFGTQLWQRTLLDNYKKLVVFDSAFRDVAPSARAGAVDVANAVRSMVQHNGQYIWLQDLYRLVFGFHTEEAMHRKSVTVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U691</accession>
    <name>A0A179U691_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase iota, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02727">
        <property type="protein sequence ID" value="OAT02727"/>
        <property type="gene ID" value="BDCG_08181"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08181"/>
    <dbReference type="OMA" id="IVTCNYE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="14"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="748" mass="81223" checksum="7B6C65F6FD3D2CE0" modified="2016-09-07" version="1">MPSRCAEMIVGLSCTLLDYDCFYASVFEAENPALKSLPLAVQQKQIVVTCNYEARRRGLRKLQLIKEAKKVCPDVVIVPGEDLTKFRDASKEIYSFLRGFVSGWGGRVERLGFDEVFLDVTSLVDYNIDLLNHNDLSSSFFHLDKTDPTQGFAYDARTVSGPSYPPSGQTPHTSLNGSAPSATSDSQTHPFSPNSNNANANANLQLLQRLILGSHLASYIRHQLEEHKSYTATVGISTSKLLAKLAGNVHKPRNQTTLLPPYNSTNDDDDAYFDHDDGDDDDYDEKHAQQQSNIIRFLDAHDISAIPGIGFKIAQKIRRHVLGRELSSGIYEQLSKADYVTVKDVRLHPNMGPLTLNELLLLSSSTSSGSGGGVGSGALPKDIGMKIWGLLHGIDPSPVAGARAVPTQISIEDSYGDGRLEGLDVVRGELVALAGSLLRRMVVDLTEEVEGEEDGDDCDGDCVQSEPERPEKSRRGKSTKRRWLAHPRTLRLSTRIRLPPLPDGARDFSAGRVSRSCPMPTYIFSSLLNTATTTTTTTTTTTTTTTTTTTITPATTNNNRNHTHLETNDNDNDDKPRAGVHEAMVVPTIDPLAMRLVNETILPLFRRLHPEKSGAGKICVMNIAVTNMVMVAGVGGKGGAGRDIGRMFRSQKRVLREWRGEDGDGDGDGDDGGLLGGETVESTTIGNNDDDGGGDAADPDDMWDSEGDEGDIDILGNGDAMMTECAICGALMPHFALRAHEVYHSVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6F9</accession>
    <name>A0A179U6F9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis specific protein Hop1, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02767">
        <property type="protein sequence ID" value="OAT02767"/>
        <property type="gene ID" value="BDCG_08289"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08289"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="SSF56019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="480" mass="53591" checksum="45AF8B23F592F89F" modified="2016-09-07" version="1">MEIFDAIEKNFLEALQMTIFVDKTKSSHVLESYTFTFKYTPAATGGGGCKQKDGGDDVGKQLASVSLESTGCTADMKTVKTARHGLEMIVRRLITLSAFLPMLPNERYMELHLFYTDGSPPGYEPPGFKAAEHNDLLFAQNEMWSRETQSCGAMETGIHSVGLKISSLKWSGTDYPSSEYVPEIPADIGYSNRVRRDEDIGISEMDVAVQDLGLSTQGSSQVSTQTRQDEAFKKDLQKMIPPVTSTPDSDFIPTQRNPDCLQIATAKPQLSQVKLSQLGARNQMFSGETSLHYDQNKGHSGHINPDVVRCECGSNSENRDMLQCAFCKTRQHLTCYGFIHAQDPAIPETHACYKCLLEPQERHLVQDMRTLVLLRRALRVIIEEGYPNRVRDFAQKLNCNGQTIVQITDMLRKQGFLLATPGSKSKGFLEKGLPKFTLSTETAVKQRLRNEIFNPLAKITHHVCLFFSCGCGTVDWQVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6W6</accession>
    <name>A0A179U6W6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08734"/>
    <dbReference type="Proteomes" id="UP000002039">
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            <end position="95"/>
        </location>
    </feature>
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            <end position="188"/>
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            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="436" mass="49773" checksum="2C07D51823E4B88F" modified="2016-09-07" version="1">MARHQMMPSIECQTPIVARKHLAPEAKGKQAKRVKREPQKQQPKYYRRSVRLSNKKALTTDSPTRIHNREQNTKPNDKRPCEDQARSSPKRPRSSTSLAIEYPFVEEQRDIANWKKVDLIGYWCKNDRWPIEYFEAQPGQIENMSHLLAKKKSTASLRRKNSNSSLVTGSNTPTDQESRDGKSASTEDISRVIVPSAESLAVDGAKTLKHLVESVNEQWSSSIAFCGPRPQPDYAVGFGRSAFTEDQLKTFEPFLGYDPDTYSSYFLATFYMYFPFLTSEVKGTAALDIADRQNAHSMTLSVRGVVELFKLVGREEEANREILAFSISHDHRTVRMYGHYAVIEGDKTSFYRHPIKTFDFTSEEGKDKWSAYTFTKNVYDIWMPDHLKRIRSAIDEIPRGLCRLSRSYTQYFLHPTDAAGIEATKEAEIACINIGG</sequence>
</entry>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
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                <person name="Ding L."/>
                <person name="Gujja S."/>
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                <person name="McEwen J.G."/>
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            <dbReference type="PubMed" id="26439490"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAT02711.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
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    </evidence>
    <sequence length="403" mass="44213" checksum="0B99237A45F04AD3" modified="2016-09-07" version="1">MSAPTFPEDPVTQRPALQSADFRLTVRQNPERARVAGGKEKERKPVDPPPIIQLKIDETKDPGQNYLQSPFYFMCCTLYNATEDTPATTAQSTALAGTLVSSLHRLKDTDNMGGFFVFGDLSVKIEGEFRLKFNLFEMREVKRCGGTRDEVVYIKSILSKPFTVSPPKNFPGMAESTWLSRSFADQGVKLRIRKEARTLLKRPMPRAEPEYPAPLAQPRSPERPGASSQQIGAAYQPSRDYPFYNGPEAKRSRSSVDMSGRGLYEGDARYQYQPHATNPYQNQAYQQGMMQGYTTAGTGVSDYPIRQAPQGSTPTPFGFADESMGSIRSPGAGGYMGQPRYQSYSGAQMPYNLSSSAQMSQMGESTPGRTGQAANMGGIVSGQSFSQPAGHMQSPSQVPPAWG</sequence>
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    <accession>A0A179U6Z8</accession>
    <name>A0A179U6Z8_AJEDR</name>
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        <submittedName>
            <fullName evidence="2">RNP domain-containing protein, variant 1</fullName>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">ER-3</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="OAT03089"/>
        <property type="gene ID" value="BDCG_09112"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09112"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6Z9</accession>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
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                <person name="Desjardins C.A."/>
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                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
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                <person name="Whiston E.A."/>
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                <person name="Zeng Q."/>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03078">
        <property type="protein sequence ID" value="OAT03078"/>
        <property type="gene ID" value="BDCG_09080"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09080"/>
    <dbReference type="OMA" id="KIDAMFV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT03078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="317" mass="35415" checksum="A1BE7C33B53126ED" modified="2016-09-07" version="1">MHETKRIAQLSERLHVALDADTIIQSHTPFADLVKGNKVQGALENKCVLIVGGGDGECRSVAQEYGFKNVVTPADIFRSHPEIWPFSHAFNDYYGRFASQLPRRIDPIDPSKSLKIDAILVFNDPRDWALDIQIIIDLLLSSQGIVGTYSAKNNSPDLPNRGYQQDDQPPLYFSNPDLLWAAQYHQPRLGQGAFKASLEGVWAAMTGGASLAMTVIGKPCELTYRFAEKRLNQEREKMFHVEDLQPLEAVYMIGDNPESDIRGANSYKSPFGTKWNSILLRSGVYSGGTPTWPPKVIVDGVKQAVDWSLVQSQWPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7H2</accession>
    <name>A0A179U7H2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02891">
        <property type="protein sequence ID" value="OAT02891"/>
        <property type="gene ID" value="BDCG_08607"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08607"/>
    <dbReference type="OMA" id="THMTQEI"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="640" mass="71390" checksum="40E9B8DED250564B" modified="2016-09-07" version="1">MSSMHNDLRRLMGVIVPDFKEEMDHQRKDETFVIEIPPNFSLKFQQAAEINHPEFANGRQLPLADTANAFVFHFGKGTAKLKAARFDLIAQRTVSVIAYVNLLKCIWLMKHMEGYQASEGSELSHWPSYVRALNQELSHECRRFSPECIDRIFAPDLSRARLEQSVFHIWPEIRRTSNLPSGQHRKRAMKEIITVPLQSDSPNVVTSLRFLQILNDMPSQHCLIVTAEEQLENGMVIPERRIIDVNLESASLIPLYAMPTFSRDTNDVLLRTPGEDNKISFPSMKDLLRFQHAFTGYKPYLSYSQPDAKVAFVVSDEKPIVEDAVVQLWIPKRLQGYFVKEEQSRAEEPWVENYDILPTSPITVPRSSVPPSPLNMFSGSPQSLFSAANRSSTQPADQRSLGSYSSSTAPSDSSRGSMGSGDHAGMNFPSLTPYSSRRSSTMTSISSKTSQSAVTVVNMGDTNGFLHQKPKRPLLVIFSRSVVGANELAITAIKIDDKTAVNVERCDCRKANSSCAITAIEQAKGKSCLEAQRFVANEGVADFNIAGLGFTRRKDYPHAAFKGLNRISISFKNPHERKSFGGYKCSCKLDTWGNFNNCIGSGHQGIFGEVRAIGQQELRAYHRASEGHADIVIGQAPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7Y6</accession>
    <name>A0A179U7Y6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02632">
        <property type="protein sequence ID" value="OAT02632"/>
        <property type="gene ID" value="BDCG_07916"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07916"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="152" mass="16846" checksum="6A5292E26FB39AB4" modified="2016-09-07" version="1">MESNDIPFKTHLNSRYHILTVPHNIEYHLPSTTKKMSQEAYQAERDLNTYQAKTGRAKEGVSDTKSGVDASVEYKFPGSQVKYGPGSTASGSDHRIIPPEEGGRYDDRGHLTKGEDFLGQGGSEDTLRMETESRSGDQDTATGRMPLKHSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U8J7</accession>
    <name>A0A179U8J7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine-binding protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02872">
        <property type="protein sequence ID" value="OAT02872"/>
        <property type="gene ID" value="BDCG_08541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08541"/>
    <dbReference type="OMA" id="VNFFYAQ"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PTHR11362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="232" mass="25914" checksum="C2C99ABC1A04C14B" modified="2016-09-07" version="1">MTLSNQFRFDRSLIGASIIPDVLDDFEPTFSLLISYPSTHTTIALGSYISPSAVRSQPVFEFHPFLIPLSSNTNPNPSPHPTPASKPHRSEKSYSIILTDPDAKSRKHPIWSEMCHWIVSNISIPWPVSLQQQDANNPSVTSPSYNLIPRVLKSYLPPSPPSGTEYHRYVFVLLEGDAATAYNITAPRKRKHWGYGGVRRGVRDWAKEYGLEVVGASFFYAKAAQGDELTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C5G805</accession>
    <name>C5G805_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin thiolesterase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="EEQ83359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002621483.1"/>
    <dbReference type="EnsemblFungi" id="EEQ83359">
        <property type="protein sequence ID" value="EEQ83359"/>
        <property type="gene ID" value="BDCG_00164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00164"/>
    <dbReference type="eggNOG" id="KOG1866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228178_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2522"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ83359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="2542" mass="288564" checksum="ECE22A312B154C50" modified="2009-07-28" version="1">MAASPLDSSSTPQPTTVAIDPQGSPDDPMEGTYPQSTRKRPRLDSGNHSNESMTMSVPSPSSTSGHCGDDQVVSGNSLVSPTTTPVPEPETPNPQRSSSRVTINMKSPTLHDNSASHTAEEAPALSDQQQEEQHEQHHISVDITSHNKPETSMASSPSHSPEIEVAEVEDMDQDPSTSNWRSLEDALRAPEEPELVHIHDEVSLAESFPRLRQDCDIRQAVEETASFLERGHPHDIAIFMSVKNWLELCVNNLSSITYDTVAEDRDVWEEVPMLIESLLRRQIDFQPDEGEGPWKFFEDFSVAFGRLAIHMTRIDALTLEHYPNDTDSAPDLLSKVYLPALGWILQVHTIPFYKMMERTFGPEVINFVARVNDQLTAAPVNLVKRLSEFAHLLLKALQPWPQFAGTFICLLTIAHNVVDSGMERKRYRADDELIASAELVDAIKSVYTFIRSIDTEYQSSISKKSSWVTNDSSESVLRFVGYTYHNTALLNSQLATQMTRDLGVDVPENAKQEEYPAIIHLGWKFQVLKRHITEGRMELRVFGMETMQADLVGVWRQHIQGNPAGINYPIIQYLVKFLRDSKIVEYIVGVDSHPQLISRSGNVVGFLVVTSTYTNNDTDIIWNTVTESEDPRTVAEVLGMLTRTFIMHQSGSNALNYLCTKLIELPLNRFDARMLEYSDCLLNAVRDKHTERMRQQPYDHVHVDVVPYRLCVRLIRDATSISEFSVEQKTNLQKFASKQLSHLLTLGLDDNDKMEMYKKCIDDISEMNDFVVGSIQALNALIPPYDSLDIRRLALDFDFTRLIITELAHTFDTVSTDFSDPTVRNSLRPRIQMLLRIIEKVPETITPELSEVLWNRVFMSKKIGECGRSLAWEVLPRATVRAGKRNPFLESYLNNYLLRISPEDYTLDILAFAEQAVSYEIRFDPPPEVDENEIIAIPGMDRLWHFILTAPPGTIEMKAINFAIDVYLDHILIRRAPRSAAEATHVALVDRCVRQLTAAAAKCKAFTDGSASGEDEPMVIVPSDGEVRAEELRFTRSLLFLRQLLQGLRTRPQYTPPQVSPQESMLRDDEINGEVLELSYQAFNGNSQTKIRTLKIGDLSTASDLAEKLTRLTGFTSFSSFSCGQRLDLAANADKTLRDLKLVGPGLLIIRKNPDAFEASVGGRRQSLTLVDSEVLKHFDDLYDLLSLEEKLAKEIFDFLAVFPPQQRVRDFVRSKETSEPEMFPLEKPYKLLYSIKALTTCVGEQILDNNADQEFISHSIQNLVVFITRPQMAEGLEDSTLKLIFARNFVECLLFALMAKSTPEDSEQLFPNPLELATRLLSFISLGQNLTSKHLSELSIQKLISNSFAVIIEASMHDSRVWDAVEQSTQIKDLIFTLLLAESRQNIRKSIAEIIFSTCGTSPSQKRVWKSDSQTKAGVDTGGKPPSATTIHIVATLWKHISARFPDTLKYGQSSQEFFEVALILFQTVAILSPEDLIFREYLRQWGDLLLSHHTNEFVGREPVDYIVLGFTHLLKMCLELSHSITGTMDTSNLMEKLFYTFLFPELSDPTETEAIQPSIPVMHNPTRQEIYNILLRLCEDQTNYEKMLTLLDDVIPYDYTHEPNWIFDRYKTIRSPEGYAGLKNLSNTCYLNSLFTQLFMNIDFRKFMIEVHVSDVDSTQNLLAETKKVFAYMQNTWQKSVDTQEAVDTIRTYDNEPIDINVQMDVDEFYNLLFDRWESQIRSAEDKKLFRSFYGGQLVQQIKSKECPHISERLEPFSAIQCDIKGKAGLEDSLRAYVEGEVMQGDNKYSCTSCGRHVDAVKRACLKDLPDNLIFHLKRFDFDVISMMRSKINDEFQFPERLDMTPYTVEYLSNPGTPIAPDIFELVGVLVHSGTAESGHYYSYIRERPTPADPSASWVEFNDSDVSRFDPSKIPDQCFGGLNDPIHGSNMPPVRFNKVWNAYMLFYQRVSSMEKAKSVYEPSLDDTPVSVPLPTELGNHIALENEIFIRTYCLLDPYHAYFIRALLEQARRFAAIEETEFSKIQKSAIILALDNLDQIISRSKELPEFENIIIELGRSVNESTEGATAVLGWTIVRPLGIRDLLLKSPNNVVRDGFGRLLITALSRLQEPLGDETTETGEQASCESNYAMMVENIVDTLDGLWGCLHLYSRAWDDYFELLLGIANFGALPVHVMLEHGFLLKCLEMVWLDREDSKRLKRQYGNYFRLIEKGRKYSHFKLVEVLYILMTHIDFTLMPSPDNRSRDCIMGKYSLTKAEAELIRPVGRNSDLIVLRKILEQQANPPVSRKIVSVFLAADPKYGLTDSICKVLEEGLRASPAYLCVPFLEATLVFCQMSTDGNQITNLIDYVSKGVDSINDSGGREHLAFFQSLVKVKNEKADKDEYWFWSSVVDRIPDWAPTLLQYPERAVRNGTLDFLRQLLFSKEYENITDDFRQFYKKIGRDLAQTCVDKLRRTYLTPADAQPPEVKAMETIALVIMHCIEVYFDESDNADAEFIQQATAVISALEQMAVDIPEELMSDGWEDNSMMGSDSDVGLTGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>C5G8P2</accession>
    <name>C5G8P2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_00921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="EEQ84116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ84116">
        <property type="protein sequence ID" value="EEQ84116"/>
        <property type="gene ID" value="BDCG_00921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00921"/>
    <dbReference type="HOGENOM" id="CLU_095070_1_1_1"/>
    <dbReference type="OMA" id="VFQINDT"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ84116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="161" mass="17230" checksum="4E72AAD58B637A4C" modified="2009-07-28" version="1">MDELSTSLSVTIGLPCTNSVLNPADPLELTVSVHNNNPNQAVTLLKWNTPLDPQANVLGVFEVREAECGTPVDSLVAKISRKLPPTPEDLVEIPANGVKEVQVTLRPMGFSAGHQYKISAKGRWQALWAAGLDDVIATDSVNMACATSGNFESNVVMVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>C5GC96</accession>
    <name>C5GC96_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="EEQ86947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ86947">
        <property type="protein sequence ID" value="EEQ86947"/>
        <property type="gene ID" value="BDCG_02067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02067"/>
    <dbReference type="HOGENOM" id="CLU_586579_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ86947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="511" mass="57102" checksum="1A4D4887F5895747" modified="2009-07-28" version="1">MAIRTRLWPSTPAILHSRTHGNGLCPFNSRTTNGQPLRFAEVVLPDHAGRSSNSLRRHNDSYYWKASCEHASELAPLTKRNLTKLTKRLANRGIYEPSSSTTPWGTTGEEYRSKTITKEFGDPRPYKRTPSPCPPSNAPISRGPEKLCPFSTTLTTHEPHQCTLGIACLLEVDDLNYHRYMATQIAAKAREARLSHVVIESGQGYHSLESLKATSKNSARLLLEKCKLHDLPRLDPMAVLKKIQSPEFWETERRYLENPGCLAKRQTRSVTTMPTSAFPLPSPEPITPEISQYMEQTWPPASIPPVHIGERDVHPNNTLHNPATQRSQMNEKKDAMLPEASNQIGDQMNAHGKRKLVKEARVTGNFSSKHYTVQSASAAGNPNTSTSRDGSQSDSSHLPNPTTTQRSTRRNMQQTSGPSNLSRTTKVKRMSHDQQQPASSCKPPVNKPRAEGVSTMPRSQIMHTNPLRSARLSKTDNVGRQTEREHNPAVALGTMKHSNFKKRKIFSKDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>C5GEK7</accession>
    <name>C5GEK7_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDCG_02726</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="EEQ87606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002624019.1"/>
    <dbReference type="EnsemblFungi" id="EEQ87606">
        <property type="protein sequence ID" value="EEQ87606"/>
        <property type="gene ID" value="BDCG_02726"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02726"/>
    <dbReference type="eggNOG" id="KOG0618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000430_4_0_1"/>
    <dbReference type="OMA" id="HDPAEPN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
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    <sequence length="2098" mass="232842" checksum="D791D193EFBE23B2" modified="2009-07-28" version="1">MARRQRTRDRELRQGSESSSTGSWRSHDTARQGSQSHDQGQGPADVRPTPVRSSGQEPRLRPISKYRSSSRSNRSVRSSSRRSYSPDISPTDMRSGFSSHRKTLALLGAAGYPPPYFPDPPRPPLRRRSPSWTPPPSLDRNALKPSGAPGTFLNDGSDQEVSPAFPPAATARTGGSDSPDDPMDQDHRRPSAASATTVSSQGSKDSTGRFHKRLQRFFGEDQGNMSDSALSHPPKDISNYGDLPIHGDPTDPDLARFTGTTEEQNPDKDSRRKKTARHRHSRSGEEKSVYLGTEFPHIFGSSDQENPKPAFSYLKNGALSPTSSSGTFGARSTSPSPSVRSGHGQRSPGGSSNKRSFFTKIRRHPKVPIASSLRHIPASSKAAHEGSSKGAKFLRRDDSPARRVRNASFDSVTNPKPWEMSDSDRKKDNLGKGASKFRHPRFPFGHDGGHKYHDKNRRNTFEEDRIWKLDTDLSNLSGIVAQPRPISPTDSGGIYTGPSQPEERKNKKEFQNPFDAHVAGDWHAPESWAVRKAQDDILSRLPELPDDGIAVDEEGRPYCVRIFRIDSTFTTLSATLNTTVAEILEMLGRKSFLQDELNNYDIVFRKNDFSRTLDYGERPILMQKRLLEQAGYQPSDRIADVGREDNSYLCRFTFLPTKLSGYSSLDTDLGINESQKFSHVDLSGRSLITLPIPLHKRASEIISLNLSRNLALDIPRDFIQACINLREVKYIGNEAWRLPASLNLATRLTYLDVSNNRLEDLDHAELHKLHGLISLKMTNNKLSTLPANFGDFPLLRSLNISSNSFSCFPEFLCNLKSLVDLDISFNKITELPNIGKLTTLERLWVTNNGLHGPLDETFRDLVNLKEIDARFNSITSIDSITQLPHLEHLMIGHNAVSTFSGMFPKLRTFTLDHCPVTEFDITSPVPTLTTLNIASAKLVQFKDSLFANIPNLTKLILNKNHFVTLSPYIGTLRKLEHFSIAKNPLSTLPPSIGCLQELKNLNLRECNLSVLPEELWYCCKLETLNVSSNLLDSFPKIGDSPPIPPNELPVNGGTPVTTPGLSSPDFEELGKLEDFETRRPSYASGGLLSVGSSPAGSHTNRKGSVVSLNNPASAARRSSIASRTPTDQASSRKDSSFSQRISLTFAGSLRQLYLADNQLEDDIFQQLVFLGELRILNLSYNELTELPQGLLRRWQHLVELFVSGNQLSWLPSDDLEESSSLKVLHLNANKFQVLPAELCKVNRLGVLDVGSNSLKYNVSNWPYDWNWNWNRNLKYLNFSGNKRFEIKPTTSYASGSPTGHGTDLTNFNSLNHLRVLGLMDVTLTIPTIPDQTEDRRVRTSASLSGSLTYGMADTLGRNEHLSTVDMLVTRFRGNNCETILGLFDGHTSPNGGSRIAKYLQEHFTSTFTDELKKLRTGGGETPLDALRRTFLSLNKDIATAAQRSMDEREQRHLDRAGPPSSKLLTPDDYTSGGVATIVYLQNMELFVANVGDAQAVLVHSNGDFKFLTRNHDPAEAGERERIREAGGFVSRNGKLNDKLSVSRAFGYYPMVPAVIAAPSTRKVTLTTQDEMIILASGELWDYVAPDLVVDVARSERADLMRASQKLRDLAIAYGATNKIMVMIAGVSDLKRRGERPKLRTPSLSMGPSPLGDDHIFPPPSKYKKRGAPSDSRLARLDRVEAPTGELAIIFTDIKKSTSLWETYPVAMRSAIQIHNDLFRRQLAQIGGFEVKTEGDAFMVSFSTATAALLWCFTCQSQLLEAEWPTEILESAACRPQYDSDDNIIYRGLSVRMGVHWGTPVCEKDPVTGRMDYFGPMVNRASRISAVADGGQIFVSADFVAEIQRNLETFADYDRASSIDSSEGAYFDDYLSNSIRRELYQLSTQGFEVKDMGERKLKGLENPEFVYLMYPHSLAGRLNAPRESIDDPDTLPIALGRDKHLTIEASLVWRLWTVALRLEAFCSALENFGEVGIRQPEMSLLNAVRERPGEVTDSLVLNLIEHQVTRIETCANTLTIRHMIRPFNRANSLKDIAVPMAEILGELQVQLSEYKALKEQIDPSSLVSHQVPHAAVSVLKSAGQSSSAVSDMLAGGSSGSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>C5GFL2</accession>
    <name>C5GFL2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-interacting protein, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_03202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
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        <property type="protein sequence ID" value="EEQ88082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="EEQ88082"/>
        <property type="gene ID" value="BDCG_03202"/>
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    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03202"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AIP3-like_C"/>
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        <property type="entry name" value="AIP3_C"/>
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        <property type="entry name" value="AIP3"/>
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        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="554"/>
            <end position="993"/>
        </location>
    </feature>
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        <location>
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            <begin position="1001"/>
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            <begin position="771"/>
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            <begin position="882"/>
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            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM00806"/>
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        <source>
            <dbReference type="EMBL" id="EEQ88082.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1089" mass="118648" checksum="4946E0612D94C26C" modified="2009-07-28" version="1">MDSSSSSSQSRSRRIRSPAFDRARSPVVQQMPSASLSSGGGGGSGGGGGASAGDAANMSQPVGTRASSGSGKSSLSRSAPDKQLSQIEKSVTHLLVATKQLLETLTQWSRQRASESEVSDVYVRLGYEFNLACRAFGAIGVDTSDLGPVPDLLRTILEDTLSQNASPESLDRYLPRIRDIIINLLQGLKKKQAKLRSRQMKDSLPRTARHGSAGSVGSGDNSLNQTMDETPSVSQLPPKRQQELSRQNNAMKSYGDTGFSRNNSSSNWSNDRHGQSFAEREASKRDPQKSAASSSSSLSSSAMQNIPVMPTYPDQSMNGPRYDNPPSFSAHDFPHPPPPTPPTSKQNDAIGMLQRSGELERRASRRFSAYQIQKHLGPSPNGVPVIPSSQNSPVPNRGRDVRESMNAVRLRGSYLHSKQRSNNRTLESALGQTTSSPDRREPVKKPQLDTSVASTEDDGPLPKTPTDKLGSPRRYESRDMPTVGGSLPALPHILERDSGSETFEGPPGKSTGQQSAPANGTQHAKTASTSSDNSPAGQFTPESSPPPSKEITLFLQYRSKIKKYVLPEGYSELTLGRLQLAFIEKFAWNTHNNGVDLPEIYLQDPVSGVRHELEDLSDVKDRSVLVLNVEPLDEVKKHFDDGVGGLRRLIEGVREIVDGQGTSIQRLTDRQSEAAKEIARLASAPPPAATSKSRVTSDGPMSGGGNHIAELQDIRRDLAVLRQTYTSFTVDISNSMGSIRSKASSVKNAANEMTVPSFEGDAGRARVNAGKKELADESERIVARVDDLQDLVEDLRKDVVTRGVRPLPRQLEAVGRDISAVTKELKKMQEFLKREKPIWTKIWEKELQLVCEERDQLTMQEDLVIDLEDDLEKATQTFGLVEQATKQQSLDSNSNTTPGPHGLRNVSRNFPIDEPLDPMKAKDYLLGEVRALQPNHENRLEAIERAEKARQKELETRRVGPLQKELGKFVEEGKLKKSGGFEEIERMRKAKEDRIRKEVWERMNGIVPESEQNVEAATSTATSPPPIDDKPPEVDNPESAKTVGPGEEHANPSSAGKRSGARGSGASDGPAPTKDEAAKSPKSPTAPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C5GGB2</accession>
    <name>C5GGB2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="1">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_03318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.27" evidence="1"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="EEQ88198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002627578.1"/>
    <dbReference type="EnsemblFungi" id="EEQ88198">
        <property type="protein sequence ID" value="EEQ88198"/>
        <property type="gene ID" value="BDCG_03318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03318"/>
    <dbReference type="eggNOG" id="KOG2449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="105"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ88198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="589" mass="62837" checksum="8CADDFFABB9BEA72" modified="2009-07-28" version="1">MAARRAVARSLPTLTARSASSPRIPITSVSARSITTTSTSTSRMASKLPTSHAALRRLHATAQQLSPASAEAAAPYPAENYPMSHSPLASPVNTCNFIDNKFLPSNASTWIDLHDPATNNLVTRVPQSTEAELRAAVESAQKAFPAWRATSIMARQQIIFKFTNLIRANWDRLAASITLEQGKTFADAKGDVLRGLQVAETACGITTQLTGEVLEVAKDMETRSYREPLGVVAAICPFNFPAMIPLWSIPTATVTGNCLILKPSERDPGAAMILVELAREAGFPDGVINVVHGSAKTVDFIIDEPAIKAISFVGSNRAGEYIFTRGSANGKRVQANLGAKNHAAVLPDCNKNHALNAITGAAFGAAGQRCMALSTLVMVGETKEWLPEIAERAKALKVDGGFEEGADLGPVISPQSKKRIEDIIASAEEEGATILLDGRGYKPEKYPNGNWVGPTIITGVKPHMRCYTEEIFGPVLICLEVETVDDAISLINANEYGNGAAVFTRSGPTATKFQRELEAGQIGINVPIPVPLPMFSFTGNKKSVAGGGASTFYGKPGLQFYTQQKTVTSLWRSEDAVNTKASVVMPTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C5GJ48</accession>
    <name>C5GJ48_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH2:quinone reductase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="EEQ88923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002628127.1"/>
    <dbReference type="EnsemblFungi" id="EEQ88923">
        <property type="protein sequence ID" value="EEQ88923"/>
        <property type="gene ID" value="BDCG_04043"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04043"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="21"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ88923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="338" mass="36265" checksum="005673FE66EDC827" modified="2009-07-28" version="1">MATTAPSIPTTQKGVLVSKIGGPEVLEYKTDLPVPTPKEGEVLIKNNLSGLNFIDTYFRTGLYKAPKPEILGREGVGTIVAVGPGPNPKDFAVGERVVWMKNCGYAEYTAVPTEATIARVPEGLSDEVILAGFLSGLTTLTFVKEAYPVKRGDWILIHAAAGGAGFLMTQLVKLAGAKVIATAGGPEKVELVEGLGADVVIDYRSAQGANWTEKVMEVTGGEGVDAVFDSVGKDTWEGSLKVAKRKGTVVYFGNASGPVPPLQIQLLASKNIKVLRPTVFPYIYTQAEFDHYTEELFGLLKSGQLKVRIHKVYPLEEVAQAHIDLEGRKTTGKLLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5GKU8</accession>
    <name>C5GKU8_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ER-3</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="EEQ89862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ89862">
        <property type="protein sequence ID" value="EEQ89862"/>
        <property type="gene ID" value="BDCG_04982"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01349">
        <property type="protein sequence ID" value="OAT01349"/>
        <property type="gene ID" value="BDCG_04982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04982"/>
    <dbReference type="HOGENOM" id="CLU_387299_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="568"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ89862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="764" mass="84828" checksum="7E5D8951DC2CE84E" modified="2009-07-28" version="1">MEGLRMSNHKDHLSSADEWSEMLTSFKTLQATSQSRYQAIRLSLNEAPRALSSKKDHTGLQTPTHQESSNVAIANPPDIKTQNTPEASAGLQTPTSKRLDTSSLAKSNIGIANSVIAVIPLKVAAEHAQETIPKKEDVTSSGHFSSRRQSLVPKIHPASDSDIITEVKRAIATPKKRDQDMVVLSPSPTDGSDKVLLPQYKKKYTAGSPLARGTPATPSNRQQPALPVQNLHEISNQRSSTTTNCPDTSPTNIASGTGFLSARRAIQKIPTSHGPPKPPQLANMRRRKPKVILNAPNETSIGPLKKTEIDDKLERLQREGKQKIGQQLRGIDLHAAEGPSPLDRARQGEGNDPTSPVAKEISLALAKRDIAALSPSLHDSRSGKNSSGDTGLDNGDSSDKAAYRTPFSERNSDYSEQRNNHYSMSGGDNLSMSVVDWHHRPWDSHSGPKYTHRFKNWLKTVGELDRVWVDTNSLEFNDANYHSSGGRGTFHSPVKSPITYLDPADPQSAAHAHETASGYIHNWNSQLKRERQEAKWKKNQMAMQMQLSQQCRQPLAIEMNPHTPKLNLYLRPIETKDIPGLLKLFNSYIQNTVRCVDLEPLSLESLEERIAECEREKFPALVAVEQKPRLGHALSGEEEEIFGCILACDFTGPATIHRYTAELELFVDPKYCRLRVGSCLVDKLLEICDPDYYPNQGYHFDCAAAQADVYRAGKNRQVARLIFILHHVADNDGDYQWTKEWLVSKFGFEEQALLKGTGLKEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>C5GMY9</accession>
    <name>C5GMY9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="EEQ91037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ91037">
        <property type="protein sequence ID" value="EEQ91037"/>
        <property type="gene ID" value="BDCG_06157"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01836">
        <property type="protein sequence ID" value="OAT01836"/>
        <property type="gene ID" value="BDCG_06157"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06157"/>
    <dbReference type="eggNOG" id="ENOG502SEH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121514_1_0_1"/>
    <dbReference type="OMA" id="HREGIME"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ91037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="127" mass="14003" checksum="AAE3967A3915C775" modified="2009-07-28" version="1">MSFLAIPSTARFLNRPIAAARVYTPCLSQAFHQSSTRNALKESDRNRDNVKEAIRISKQEHNQQRKDGDPRWHESLASVSEAHVKADRGEITEAAAEMEEQMRQAKMAGHKPASPSTGIGKGGGMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>C5GNQ1</accession>
    <name>C5GNQ1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_17180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="EEQ90582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622876.1"/>
    <dbReference type="EnsemblFungi" id="EEQ90582">
        <property type="protein sequence ID" value="EEQ90582"/>
        <property type="gene ID" value="BDCG_17180"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_17180"/>
    <dbReference type="eggNOG" id="KOG0750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053371_0_0_1"/>
    <dbReference type="OMA" id="KATFFQN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="220"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ90582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="310" mass="33350" checksum="E4363965B6F83AA4" modified="2009-07-28" version="1">MSPPALVAPGAGSAAKDVKRESGMARLLGSGSSGIAELLIFHPVDTTAKRLMSNQGKIANVSQLNKVVFKDFADASVARKFTSLFPGLGYAAGYKVLQRIYKYGGQPFVRDYLAQHHGSSFDNAFGKGTGKAIMHATAGSLIGIGEIVLLPLDVLKIKRQTNPEAFRGRGLFRIIKDEGMGLYRGAGWTAARNAPGSFALFGGSAFAKEYIYDLKDYNSASWLQNFVASIVGASASLIVSAPLDVIKTRIQNRNFENPESGFRIVSSMIRNEGPTSFFKGLTPKLLMTGPKLVFSFWLAQTLIPAFGKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C5GNQ4</accession>
    <name>C5GNQ4_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_05705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="EEQ90585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622880.1"/>
    <dbReference type="EnsemblFungi" id="EEQ90585">
        <property type="protein sequence ID" value="EEQ90585"/>
        <property type="gene ID" value="BDCG_05705"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05705"/>
    <dbReference type="eggNOG" id="ENOG502SCUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130004_1_1_1"/>
    <dbReference type="OMA" id="NQQMEGV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHZ" evidence="6">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ90585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="130" mass="13841" checksum="495B3955C08FBDB4" modified="2009-07-28" version="1">MGDTGAAAFGGGATSGLDKGKGKAVDTHPADDVSMGEDEESSSEESTVEDLPVEDDEDEDTAQDNLEPISADNIISDGRRTRGKMIDFAEAAKKAQEAGDPIDDEDDDDGDFELQDDTTTNQDDDHIMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C5GQW3</accession>
    <name>C5GQW3_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BDCG_06961</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="EEQ91841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002621745.1"/>
    <dbReference type="EnsemblFungi" id="EEQ91841">
        <property type="protein sequence ID" value="EEQ91841"/>
        <property type="gene ID" value="BDCG_06961"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06961"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001963_1_0_1"/>
    <dbReference type="OMA" id="PQRTGMQ"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EF-hand_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="19">
        <location>
            <begin position="175"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="19">
        <location>
            <begin position="455"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="21">
        <location>
            <begin position="1501"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="580"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="886"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="667"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="896"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="922"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="971"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1017"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1035"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1170"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1192"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1225"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1292"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1386"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1411"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1429"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EEQ91841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1533" mass="166231" checksum="FC17685E6984EE6B" modified="2009-07-28" version="1">MYSNTFYGGNSTRPGQPPFGQQTSLPPQQQQQQQQQPQQQPFPVFSQPQQQNLQPGAFMPQPTSFAGSNQMQQTQMPVQQPQPTGFPSQPQFTGFPPQNQQPPSTATTTTTTTTQQPQLSVPAPSSVAPHQTGMTSTQIAQSFAQSTSPTAPAQPHVSTGSKIPTMRLSFITAQDQAKFEQLFKSAVGNNQALDGETAKDLLMRSKLSGSDLSKIWVLSDTTKSGRLLFPEFALAMYLCNLKLTGKELPSTLPERISNEVSSMVDIISFAVPDDRPAPPQTTNVPKFAAPLMQNASAPPPPQQPQPQQASNTQLLSQLTSQPTGFYNQATGLQPTIVQPQQTGFPGQNTGLRPQQIGFMSNPQPTGYTGPRPPMPPMPTGFGSNLSPSQTGLAPLNAQPTGAPGQWGFVNAPATGLPNIEALQQRLMPQPGREGGFTTQGLAGNATIPWAVTKDEKKIYDQLFKAWDGFNKGFIGGDVAIEIMGQSGLERQDLERIWTLSDPNNRGRLNMDEFAVAMHLIYRKLNGYPVPNRLPPELIPPSTRNFNDSIGTVKSLLSQDAESRKSSGAFLQPQQTGVSYLKNHSFRGGSTTPGIGRKDATVFKNNDDAIGYRSSARRRAGGGGTPSPTPSPTPERSYNDASVEQLKKKIREAKIMLDATDFQDQNRAEEEETLNRRDRREAESLMERIRRVQDEIDTDPKAAFRNTDSGAERRALRRQLQSYQDQLPELASNVRKVERSISDAKLELFRLKDAKAHPSAAAAIVGTGPGGTVTESDRIKARARARMQARAAELAGRPPPPTDDDGAAARRLEVEAANIKAERERNDAMTRDVEESVKEFTRSLEDSLKDVDEDSTREHERRRWEEALGVEDTIRDFIYDLQRGSRTAKVRKEENTPAPRSLSSNRYDTASPNGDALPVRPSPPRSTGSSSSLAGLTHQERVASAKERAQKRIAERMAAAGLKPSSDGGAETLLERQEREKREREERRKRAEEEDAKREQERQRRIAEEQNGPPVKAVPTGKKPPPPPSRKGKADGIAPAETKKSVDVDNLAREKAENEARERALREEQQAQEAESRRLEAEARQQEEELAREREAAQARLKALEEQVRQGKIKKQEEKRRKQLAEKEAKEKEARLAAQRAELEAAQARERELQRQLEGLDEEESSDDEGPIEITPQNSTPTQSAVLPSVTTTTAAPPPPAPRPATPPTAPFEPEQAPKVAAPASTALSSPESVKQRAATDNESRNPYFRKLSQSADVQPLPSFHTPPEQIPDPLAAAASAPAPPKAEIQSTNPFHRLAQQQESQKSAFAAAPIPGPLERKSRVRPEDDEWSVAESENSSDDDDDRPAGGSAKHLASILFGTMGPPRPLSAMEEKPESKPAMAVQTSPIAAPPPPPPPAPPVVSEPPPPAHPDEDAEEDDEFDENDFQDAPSMPPPPPPPAPFTDAPPTAPPPPPPVPSAAAPPPPPPPPIGAAPGGPPPPPPPAVGAPTMPMAAAPGAPAGRGALLASIQAGKGLRKVETKDRSAAAVSGRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C5GRC3</accession>
    <name>C5GRC3_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Chitin synthase</fullName>
            <ecNumber evidence="4 12">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDCG_06553</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ER-3</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="EEQ91433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002624361.1"/>
    <dbReference type="EnsemblFungi" id="EEQ91433">
        <property type="protein sequence ID" value="EEQ91433"/>
        <property type="gene ID" value="BDCG_06553"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02012">
        <property type="protein sequence ID" value="OAT02012"/>
        <property type="gene ID" value="BDCG_06553"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06553"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_3_1_1"/>
    <dbReference type="OMA" id="AWILHYV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004834">
        <property type="entry name" value="Chitin_synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="PTHR22914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin_synth_1N" evidence="14">
        <location>
            <begin position="164"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EEQ91433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="900" mass="102646" checksum="9AE3F04AA9E5B79E" modified="2009-07-28" version="1">MNPNRLDPNRTPSPGRPLQGYQLEDNPYRQYGHLEMPSVDRLADQPTYSVENIDNSYGHNEAYEIAHPYRPSPIARTEYTISPEAHHDAYYTQPYQPTTSPSDYDGNRFPSQTPQPYQDDQVPMLQHPDNPYSPNPQLTEYNDEETAIAPTPSPAPIRRWKTVKEVQLFNGNLVLDCPIPPKLLSQVNHAAPPERDEFTHMRYSAATCDPADFYNERFTLRQRLFAKPRHTELFIVVTMYNEDDFLFARTMIGVFKNIEYMCSRTNSKTWGKEAWKKIVVCVVSDGRAKINQRTKAVLAGLGVYQDGIAKQQVNGKDVTAHIYEYTTQIGMELKGNQVHLKPRSGVPVQMIFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLLDAGTKPGRDSIYHLWRAFDLHPMCGGACGEIKTMLSHGKKLINPLVAAQNFEYKMSNILDKPLESAFGFISVLPGAFSAYRYVALQNDKNGQGPLEKYFAGEKMHGANAGIFTANMYLAEDRILCFELVAKRNCQWILQYVKSSTGETDVPDRMAEFILQRRRWLNGSFFAAVYSIAHFYQIFRSNHSTTRKFMLIIEFIYQTINMLFAWFAIGNFYLVFHILTKSLGAENLLGEVGRILGVVFEWLYLATLMTSFILALGNRPQGSNKFYMTMVYFWIGIMIYLAFAAIFITVKSIQAETADGNFSFSSVFSNRQFFSMIVSLMSTYVLWIVASLLFFDPWHMLTCFLQYILLTPTYINVLNIYAFCNTHDITWGTKGDDKAEKLPSANLKPSGKVDVAIPQDDGDLNAQYEAELAKFASKPPKEVRAISEEDKQEDYYRGFRSAVVLVWIFCNFALAAVVLSAVGLERINPDDTSGEQRSTIYMAVVLWSVAGLSLFRFVGAMWFLIARLFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>C5GRX4</accession>
    <name>C5GRX4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Opsin 1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_07436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="EEQ92316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ92316">
        <property type="protein sequence ID" value="EEQ92316"/>
        <property type="gene ID" value="BDCG_07436"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07436"/>
    <dbReference type="HOGENOM" id="CLU_054785_0_0_1"/>
    <dbReference type="OMA" id="VCRQVFW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="entry name" value="PTHR28286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ92316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="297" mass="32565" checksum="1DB0889D368FB90F" modified="2009-07-28" version="1">MIEPTKLDAFRPLSTVGPIPTVIPNEPIFQEIGGTGHRTLWVVAILMLLSSLIFYILAARAPVQKRLFHVLVSLVTTISFLAYFAMATGGGKAYNHVIIHEHHKKAPDTVQHIYREVYWARYVNWGLTFPIILIILVLLSGMNGASLLVSIAANLVMVVTGAISAYGGPTGRKWAWYTISCLAYLTIVYQIGFNGRRAVASKDNKTKTLFGSLSGVALVALLVYPIIWAASSNARRMSIDAEVVTYAILDILLQGLFGYWLLISHDSMSAYSLNMDGFWARGVGTEGTIRIGDEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C5GSC9</accession>
    <name>C5GSC9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="EEQ92062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622480.1"/>
    <dbReference type="EnsemblFungi" id="EEQ92062">
        <property type="protein sequence ID" value="EEQ92062"/>
        <property type="gene ID" value="BDCG_07182"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07182"/>
    <dbReference type="HOGENOM" id="CLU_030656_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="SSF49417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="3">
        <location>
            <begin position="118"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="1">
        <location>
            <begin position="118"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ92062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="616" mass="67356" checksum="F2FECA5D257EF70A" modified="2009-07-28" version="1">MNPIEPSRGSSSTSPSSVTSSYPYASLRHSIPSTATSTEGFSTPSSYSHPTNLQWNDRMGDLRIQRVPALQPPSGMSPPLQSQGTVVPGPTGLITRTDPYSMSYSMNRNAYSSPHHTMNDISRYSQYPATRALDVHTNGSSMYNHLMDTSSRTSQSSPEAPPFNETNVLHSVFTNSHQTLNTEIHAKIHKGFFQVDDKWTCYRRNYFSVSCSFSLRPWTPNSPLYVQLPNSNPQSVRSFAMSISAVVNAQENETRELVQHTPKRDKQSEKKPGRITLHPTQPPSLAMNHPSSLGPNPISFAAPPHTSSLPLDYGSSFGGATQASQPPTSHTFERIQFQKATANNGKRRAQQQYYNLVVELYAEIPTSNGVDLQWVLIAKRLSHPMVVRGRSPGHYKDGRRDSSASMGPDGGTGSSGDGNGGGCLPPGMGHGPRTHLSLMSQYSGSHRAPTSYNYHRLSSTDHSPLTTSPLISSSSSSPDYNNYTMMNGSMDPLETIKDTTTAGAYGDPTFTTASPDSRKICIEPSSLRLHMPSYDDDAAVKTQEEHDATYSAAFDPMIPALQNEHDGSNQYLKRHNTTSYLSQLSGPRFGGSYASRSGDTSYSRFDSTQNPQSLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>C5GSD0</accession>
    <name>C5GSD0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="EEQ92063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ92063">
        <property type="protein sequence ID" value="EEQ92063"/>
        <property type="gene ID" value="BDCG_07183"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07183"/>
    <dbReference type="eggNOG" id="ENOG502SDW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190851_0_0_1"/>
    <dbReference type="OMA" id="MAWASIG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ92063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="65" mass="7383" checksum="F1B756EBEA3546AB" modified="2009-07-28" version="1">MSLWSSYRNLSPRTRFLFGAGLMAYATVGMWWSPKIEEALGMVPSSEEQAELDRKLSVKISSVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUA6</accession>
    <name>A0A179TUA6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99433">
        <property type="protein sequence ID" value="OAS99433"/>
        <property type="gene ID" value="BDCG_00418"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00418"/>
    <dbReference type="eggNOG" id="ENOG502SQAM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="746" mass="81299" checksum="62AE729449E97F40" modified="2016-09-07" version="1">MTLSCPITHRCLILKSHDPILPPTSETKPNRITASARSDFCSSGLLLQAQYTTCRNILPKSGGASCVWGQVLPIALPTLFPPARSLNTVLLRYARTASRHGHRPITRGYFLSLASPTTSSYSCSVLRLSFFSPQQPHYHSSAAPGSASSESRTGKHPFSTSPLSPSVAVRKWESLLGVMCCPLSRQVVATGCAKSPNSLCLHWEPPARSAAASNGRAKADPLAPSRSTIRRQRTLRRPHRNNNGSRSASSNRPAGYVPSRPSMPQWVESLSREALGDSATSSTATARGSAMTTGEPGASRYTPSQDNETRLDWPASSSYSSSQTRRDLGDQIPRTTALRYYSSPGGRRIRIPRESSLRFEMLHPPSWSHSTERSRRSELSSDATANSRLESRLGEIVSFSPRFAPAYPPRSNGRAMVSSDSYDPNMPLLRRVGHRSVADTSDLDATRPRHIIDGLGDRDRSLSPGGDSQHDDEDSHYHDHDDDDDDDDDDEPNMWESLFTTITPDQHLPSLDSSFTSATASASTAPSRNSANSSQSTLPSSLGANNSNPSRRPGVFPPLESFTDHNNHCDFFSSSEDSETEPDSDNEHIPTWRLMQYDDPMPISSSVSAIDDAIRRSEQQQQLRRRYQENLLGITQTIRAVVAETPANRNGDHNTTTNINTSTNATSSFTSSSTTPTSINVSFGQSSSMGDLQQVQTIIDQLTRRQDIGDDWWAAVGLSRNLGRGVTDVPARNGSGNSGSGDAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUB7</accession>
    <name>A0A179TUB7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase family M20/M25/M40 protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_00440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002625029.1"/>
    <dbReference type="EnsemblFungi" id="OAS99445">
        <property type="protein sequence ID" value="OAS99445"/>
        <property type="gene ID" value="BDCG_00440"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00440"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
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            <begin position="92"/>
            <end position="133"/>
        </location>
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            <end position="750"/>
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            <begin position="820"/>
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            <begin position="883"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00006247"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAS99445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110510" checksum="448EE6F1810FA957" modified="2016-09-07" version="1">MSGIMDDSDFDGPSDIELELNRRPQFQPQHSYCNGETPPEVQISNQCGVGHRVQAVRSVLALVLDEECVFAGLQGGDIVAWSLDTYELILSVKAHQESVLGLYLSDDASLLFSSGGDSVVNVWSTRTFERLYSIYSHHDVGDLFTVVYSSNLKTVYCGGQNTSIQWCDLQLDTPPPPPVSVHPSNRRHRFFDSKGPGGIVTLNPDAGEAAERLGQGGQSLTFKKDQHKLYAHNGYIYCMLLVRGLEEWANGEEVLLTGSGDGSVKLWELGKCPEGSLLELGELKNGSDSVLSIAVDGAFLYCGLSGGAVYIWNLDSRQIIRKLTAHSGDLWAIDVVGNVTITGDSSGIIRKFNSRFEEIGSWAAHKGTMLASAAGVFNNRRIYATGGNDNTVAIWDLTDHPQDVQEIPAVGNDEMVNGLANFVAFKTISSRPKFAGECNQGAAFLRRHCNYLGAKTKLLATGPDTNPIVFARFDAASKSSASKTVLFYGHYDVVGADMNHLKWNTDPFQLTSINGFLYGRGVSDNKGPVLAALYAAAELAQTKNLSCNVVFLIEGEEESGSQGFAQTVQKHKDLIGEVDWILLANSYWLDDHIPCLTYGLRGVVHANFVVTSSNPDLHSGIDGSSLLDEPLKDLTMLLATLVGARGKINIPGFHDPVLPLTEAEKRRYDAIAKALLPHHPEIEDYEAFTDSLMHRWREPSLTIHRVEVPGCQNTSTTISRRARATLSVRIVPNQDADKVAADLTEFAHAQFANFDSQNILTVEIAGKAEPWLGDPENDIFKLLSRAVTAAWSSAKGDRHYNYPPVNPSNQLSRREILRSNSTDSVASNVGRIISSSSSAPKTRSGHRLSAPSVPTSSTLAHGSDLAGTKPPSRPRAPCRHNASSSACEVTPVAAAETSGPQPHTRNSTSASHSPVSIARPCQFIQPIYIREGGSIPTIRYLEKEFNAPAAHLPCGQASDHAHLDNERLRVENLYKSREIMTRVFRDLGKDGAGTGNDGTLDEDGSASNDSEAGEDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUD0</accession>
    <name>A0A179TUD0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAS99463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAS99463"/>
        <property type="gene ID" value="BDCG_00477"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00477"/>
    <dbReference type="OMA" id="YSMHSIT"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="851"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
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            <begin position="107"/>
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        </location>
    </feature>
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        <location>
            <begin position="153"/>
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        </location>
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            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAS99463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="869" mass="94859" checksum="7212857B6EC20910" modified="2016-09-07" version="1">MAKKKKAKKQNNNPPPSFTKPSITSDNDIDTNSSVDSASPVAATLQDVKASVRGQDDPPITDPSEPVSSPVEASLAELSNDVVDKQEEAKEETVEKLEEELREDEFAEDGTEGKTEEASIEGGGDRKEDIPDENKQEENGNGVTASEDVSPLADARSPEDVEPESPKAPENEQVDAPGETSPDIPEACDNEDDTVFPDVDPEAEVDQVKAEREAEANVDDDDYDENIVLGHCLEETEEPVNEPNEGDEAAANEPDAPGAEAPGPDDAIKADEQDSELHEADNPVEVVSPNLEAQSDPEESPAVEPTGDPQVEDSPEVPNVEDAVNTPASVDEHAAKDPGDEEPNPPKEMPTEDTSVEERCRTEEEPTDKSTQEPLAEDTPEEEPSSADEPAPAEVPPSDDTRTGDSPPEEAPAEEPASPEEPAPEDPSSEEPVPTVEPTAEEPAAGTPPIEEPAVVEESLLEETATGDAPHGGASVDNPPVEETSTEGADAENAPAEDPSLEEPTPLEDAPKEEVIVEEPATEEASQADDPPDSNTPPDEPTLELAVNEEPPIPEVSAPTEIPTQNVPPDQLPADESVAEIARGNIDEEVIIDSPAGESAEGVTSSKARRRKRRHRSQWERERRGSKSSSDSYALRRRKGEQTVFANPMSEALGEAKKQRLSRLSSNEDRAERHRRESRRYSEGWARRGSAAKDSFDASRHSSSSRSRRESTSFTLSGISAKPVALLKLMTNGESKSNGPLLKLNVNDQYERRSSTSRPSDSSSSSRPHSNSHSHRRHRQHGEKESRSREHRSPRDSSDDADAERRRREHRRSRRADDLLEERPRRRDSHYEGRRRERRDSDRYRHNGPLDKLKDRFMGNLRTVLAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVC3</accession>
    <name>A0A179TVC3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99805">
        <property type="protein sequence ID" value="OAS99805"/>
        <property type="gene ID" value="BDCG_01339"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01339"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="983" mass="106532" checksum="2A1B8ADFDCA9D3DD" modified="2016-09-07" version="1">MPIKLPKGFARRKSSGNALEALDETPQPSFRVFERPGAARKSLDGSTTLNSSTSNSSHNKRLSEDPYANNIFANIDHPSPVDNRGSRGTNNSASTGRLYDSSASSAKFSSSSTLPSSTDIPIQDVPPPPVHDSSFFSFRSAGRTFSFGTKSSSSKSLQRLEATTPRSRGTATARERAPTTSTTSTATPHRLPDTELDMGDSLSFGNMFDGFDKEKEVQKEPLSPSPLGRGSASALPPLPTNDTQNHPTPLRIVPSKDVEPSPRTNESQNSRDGLMSREDDDIISRPPASRVRTSVQPNTNGSLSPTYNTGSTSRFYRNTVQLDRNAAVEDEDAKIVKNAVSAHRRMTAEFSPDGDFPDPLPFSENRLQQRNNVKQITRRPVLQDEESHLAAALAAEASLAERYEENANNSERQLPTKVMTPAQFERYRQQKEMTRKNSNASDTHHSDDDSDHYDEEEEDEVEKAREAAKQRKKQEAHLSVYRQQMMKVTGETIKPLDSDQNGVDKARAASLNNLNRSSFLAPEPTTNGKVSDGEDDDDIPLAILAAHGFPNKTRPPGHLTPSISNPNLRASMLSFAQGPPSVAAEPTAGTQTGRTSLPVFARNLPRDPYNIGAGLVNPSHRESLAMGGGTPSVYGAPPGFPPGGLVGVIANEERAKAMRRGSPNAVRPYDAPPGSLLGMNLNGQHNNTMPLPQQQQFLNVPGAPPGQPPGFGQPDQMSQMTQMMQTQIQWMQSMMQMQGMQMPLNMGLGSHNSTPPNGPSMARPISMLSNLNFNQPQPQGPPQVDHRTLSLLDPKWNNRQSSFLPQQHPHLGPGPGPGYTPSVAPSERSNVGTASRYRPVSTMQQPPQDNAMARSSTFTASTLRPWADAESRKMSLTSNIGGNGMGMQQPYHLPRVATEGSNVVGGLRPVSGLRASTNASVNGGQGGKDEDHHDDDDDEEEEAAWAEMMKNREKKKSGWRFKKTGSSGLGLGDLFPGSGPNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVE9</accession>
    <name>A0A179TVE9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99509">
        <property type="protein sequence ID" value="OAS99509"/>
        <property type="gene ID" value="BDCG_00628"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00628"/>
    <dbReference type="OMA" id="SINEGWD"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="383" mass="43933" checksum="9EA136CEA58EFF83" modified="2016-09-07" version="1">MSQLLARKKSTSSLHHKQLESTLTSSTTPSNQKPREEKSSQYKNPRYEVLLEIKGSYMSESKQGITEVSKSCYQTLLNAAQKIPENSLFRDDLFKATCEKVRRRNEAIIIQDITRLIVPSAENLAIYGATHLDHLVESVNEGWDNSIPVTKTRPQPDYSVGFKRDAFTDGQLRRLRDFVGELTDTSYFMATYYLYFPFLTCEVKCGAASLDIADRQNAHSATIAVRATVELFKLVKREKEVDREILAFSISHDHTAVRIYGHYAVLEGEKTNFYRHPIHKFDFTALDGKEKWTAYKFTRNVYDIWMPTHFKRICSAIDHIPSDLDFEISQSELQYSEQSNAESVLTINDDDSQPSQLGYIDSTDVTPTTSFTEQTQVFKKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVF4</accession>
    <name>A0A179TVF4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99873">
        <property type="protein sequence ID" value="OAS99873"/>
        <property type="gene ID" value="BDCG_01459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01459"/>
    <dbReference type="OMA" id="NERYPGR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="596" mass="68191" checksum="126389D7BA33FB10" modified="2016-09-07" version="1">MSSIFNGMEVPFQNPPPGLSRPFLRDMYLLVEPLAPLPDPPSRSTIQYSIKERSKLPPYEPPPGDEDFALVFSTGDTPPPSEAGPEEDFENAYFTRLEQKIKDFGRYFNSKAWMVHVPAMAEKLVKDATPGTFKHFLLLLLEPDETFAKAQHSVQTWLDERYSGRGVDNIPERGPYALWVAEKQLLLGEIELLRKLVEPLRDGGKTIYWLEKNHCRHLYTMRSLKKAYKIIIEFENETTTRTILNEEEDFSLSTLSGDFRLAVMSMRMARIDVCKESLLKLPPPTVPKFNDPTTSPASERRLHKCKNHQPRPDGTEHLDRPESSLSPQPHEDLLKYRLEAANCAGTMDDVIETMMNTARWLAKARCTESVDLFCDVARMFSPHDPPANLSNEKYSLLRVLCDAMFDTDDVGSEAPYVTDRYSEDDLDVTTNREYFVDAAASRRSLMRDLQLRMAAERPIAPTQMHGHRFSSHGSIRRGRRRARMLNKRARSEIALPRSIAHRYKFTLPADPSNWAANYTSPFGEAFQAELDRQEESRAYQCLKMICEEGLKARSRAVPSQTAPVQRAKESEVSIVHSLFIYRLKPALKSIDNSRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVF9</accession>
    <name>A0A179TVF9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_00655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99519">
        <property type="protein sequence ID" value="OAS99519"/>
        <property type="gene ID" value="BDCG_00655"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00655"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="274"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAS99519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="596" mass="66819" checksum="7EF887FEF8DB64C4" modified="2016-09-07" version="1">MQQSSSAAAQSGQWDTYVPPPNYGMIPNSPPSTPASNNDHGTNGSPPEPVDEATLIEQRRRRREAIKAKYRDQSTPLIVKALEAGNETDSTVQNSGQPMARNDTATVSHISTAAETPEDTSGAPSPTELKVSRDEDLANANVVITNGADKDDSSVDYDPTQDMREDKMRHDKRHFGEDITSGAYDETKAAKQDVLVPSPNTDNPAQVKPKNLLDIDMFAPDDDMFAEAPSTSKAPEVASKPSVPQELDMSMMDNWDDPEGYYIVMLGELVDGRYHVQQNLGKGMFSSVVRATDSKTGKLVAIKIIRNNDTMRKAGMKEIELLEQLLAADPDDKKHIIRFERHFEHKGHLCMVFENLSMNLREVLKKFGRDVGINLRAIRAYAHQMFLGLSLLRKCNILHADLKPDNLLVNENRNLLKVCDLGSASPASENEITPYLVSRFYRAPEIILGIPYDYAIDMWSIGCTLFELYTGKILFTGRTNNQMLRSIMECRGKLPPKFLRRGTLTYLHFDDFLNFRSVEEDKVTGRMVTRVLDFKKPTRDLKTRLMGKGSKGMSDSEGKELMLFIDLLDRCLSINPEKRCTPSEALKHPFITRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWC6</accession>
    <name>A0A179TWC6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc metalloproteinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626685.1"/>
    <dbReference type="EnsemblFungi" id="OAS99742">
        <property type="protein sequence ID" value="OAS99742"/>
        <property type="gene ID" value="BDCG_01161"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01161"/>
    <dbReference type="eggNOG" id="KOG4525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="SSF51101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="748" mass="83171" checksum="6FF3C062DFC76F32" modified="2016-09-07" version="1">MPFFKDLRRRSRATFSLTPSSSFNANDDVLPDKSSSTLDSPIPSLRSSSVSFLKSNSPDLPFPHLSTLSKLNGNGDGPQVTPPQRPVPIGSQSSRSNGTVHQKILLIYGQTGDARQHSVDGNITIHHSQDSFPPITWPVYESHFKALVHLIPGPNKLRLEFTSSKIQNPIAHSSWVSINYLPLVNSPPLQLAIVLGSDSDGRFDAVPERISREGNGLETAIRKFRMAAYMWQSFTGEQMYRNKFGRRCFRFEEEWQVGTLSLRDAKSHQMRNEAKIHIIRCDRTVNDLRNLSVVGQGGTKSDASELFNVVLEAIKRYFGTGDGQMQYVSALMLDTHWDIGSQKITCHAAAGSDGDNIKLALFGSYALQSYPTAMEEVVTAFTDCTRTDTNFVANYRNECGSNWEAVNSGIGGHLRSIGRLFGCRNQESGIMCGDCILLNRSFTIREPYSTRTKAQGLRLCLNEDECNWHRLDTLRFRFHACFRLPRDSPPRSDDSVQVWPVDNGKILITSSAGIAFIEIYVDNDEICRSYLEYVDGDSGNNGIPKQIALTEAEIRRQTPGSTNKKRKIKLVIYSGILSTYTIDDISKLKSKHSTAKLPTGQVGYRGNKLGQALSLDSIPEQLFLECAFIQTKLLVSVKVYHNGFIYGLEFCYEDSTSQVFGHKNSNSTRSEFVFDTRRGEILMGFYVKMGRQIDGIGLITNLSRKSAVFGNGNGRAGHTLIPPRGYSIAGISGSVASCIEELSLIITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWD6</accession>
    <name>A0A179TWD6_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_01439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99859">
        <property type="protein sequence ID" value="OAS99859"/>
        <property type="gene ID" value="BDCG_01439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01439"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037979">
        <property type="entry name" value="PPP1CA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF377">
        <property type="entry name" value="PTHR11668:SF377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="8">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAS99859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="309" mass="35703" checksum="D9E037936DEB3456" modified="2016-09-07" version="1">MADLNEIDLDSIIDRLLEVRGSRPGKQVQLLESEIRHLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDCGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAEKKQNRFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWE4</accession>
    <name>A0A179TWE4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_00230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99347">
        <property type="protein sequence ID" value="OAS99347"/>
        <property type="gene ID" value="BDCG_00230"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00230"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="154" mass="17514" checksum="10F894FE3073541E" modified="2016-09-07" version="1">MVLTTWRRLICAVDHSYPEIDISFPHAKTPPDSSGFQLKSKLESSPKWQIGQDVHCTYIHTAESNSSVLEEPTNICVMHAQNAAITLKPEEPPPRILPTYPKSVSVQSHRQNYAIFLPPLPCSNEVLSPLPRRCHQQGTKWSRHPYALYRTTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWE8</accession>
    <name>A0A179TWE8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00186">
        <property type="protein sequence ID" value="OAT00186"/>
        <property type="gene ID" value="BDCG_02100"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02100"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107093" evidence="1">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="92" mass="10118" checksum="2CB12D8D0B258484" modified="2016-09-07" version="1">MKFPFPLALSALAALAPLAWATPAIAAHSKGLEQPPYRTGLSDLDPQVQFCASYFLCKTDEECSKLEDCRVKAHYDPTRIFSDRTLEANLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWF5</accession>
    <name>A0A179TWF5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99772">
        <property type="protein sequence ID" value="OAS99772"/>
        <property type="gene ID" value="BDCG_01246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01246"/>
    <dbReference type="OMA" id="QCPGCLR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="330" mass="36481" checksum="439DD9933EEED707" modified="2016-09-07" version="1">MVCHFCHAKFRRAHAYMCHIENDQCPSFSAERYREQRVKKEALRTVMSRALGPTNKGFGLTDSSITSSLDGGIGLPLLDGRETVPTSGERSKPGTTGSSGYDATSVSMQLRGMSLWPAPGEEKEVEIGSEEQVFMAYSDAAYGRDDREVRSRFRANNSGPPTSPTGKHTPLIDLDETASKASDNTWGTWESRFAPSPMPRESETVEKRQQEPWSPSKFFSPAMGKWVCVCDKLFDSEKDFEGHIKSGIHMGGVFRCPGCLRMFKSSTALTAHCESATVRCKVNKDENYARILDEVSAGLIEPAGENEDGSIIYRTVAPSQTGIDLKNVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWH7</accession>
    <name>A0A179TWH7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00175">
        <property type="protein sequence ID" value="OAT00175"/>
        <property type="gene ID" value="BDCG_02067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02067"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="506" mass="56657" checksum="5BF18D90970DD68C" modified="2016-09-07" version="1">MAIRTRLWPSTPAILHSRTHGNGLCPFNSRTTNGQPLRFAEVVLPDHAGRSSNSLRRHNDSYYWKASCEHASELAPLTKRNLTKLTKRLANRGIYEPSSSTTPWGTTGEEYRSKTITKEFGDPRPYKRTPSPCPPSNAPISRGPEKLCPFSTTLTTHEPHQCTLGIACLLEVDDLNYHRYMATQIAAKAREARLSHVVIESGQGYHSLESLKATSKNSARLLLEKCKLHDLPRLDPMAVLKKIQSPEFWETERRYLENPGCLAKRQTRSVTTMPTSAFPLPSPEPITPEISQYMEQTWPPASIPPVHIGERDVHPNNTLHNPATQRSQMNEKKDAMLPEASNQIGDQMNAHGKRKLVKEARVTGNFSSKHCKTTGNPNTSTSRDGSQSDSSHLPNPTTTQRSTRRNMQQTSGPSNLSRTTKVKRMSHDQQQPASSCKPPVNKPRAEGVSTMPRSQIMHTNPLRSARLSKTDNVGRQTEREHNPAVALGTMKHSNFKKRKIFSKDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXE7</accession>
    <name>A0A179TXE7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHD finger domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626715.1"/>
    <dbReference type="EnsemblFungi" id="OAS99728">
        <property type="protein sequence ID" value="OAS99728"/>
        <property type="gene ID" value="BDCG_01135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01135"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="PTHR10333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ING" evidence="2">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="682" mass="74064" checksum="EA4AB40AC134887E" modified="2016-09-07" version="1">MISDDSDERGIMEGPSDPDAQATVTDFIDYTEYLPSDLVRSLTLIRGLDETYLDAAASVHELTKIYGQLPNLPADSRPDPVVLRRQISEQLGRVMNARESAYAEACRLYDVVDRHFDRLGSIKSKLNALLKTCTAISRDESAPPLAESSLETKRERSGRKAGETRSTQRITLHIDGTRQVVAGSTVNETRPQNGKPQGVATRGPNHVLRNPDSPIASTEQSDDDLGPSSSHAAEAARSLDTSKNKGKSKKQKRVISRHISQPSDSSGNAEISQIDTSTSNALAMLKPPPDDAKIGSEHFPWLRLTEWEMTKLRKKMKKNNIWQPSEIMIHRELALRGRGWEGYRAAKLNAEATGAEFVDCDDITNNYVPGKLVRKSEVNADVSRVEETKLSNRGMKLNEAKKLKRENLAREQAALAAAEAEMAARRLGDIGSTFKSLFPSPAEQNLYNNVQSGLLGTSFKANGPAVKARPKVSKQTMKKRKFEETAVLESSQDVESPAPISLATVRPSTKKRKLSKSASTSAVNTAGDEFLVESASMGIGPRTSPFVGPSAISKRSPRALSPAKLRRTTGSVAARILPTPTPPATRAGSRPRSATGASGESIGRDRPRRKSATPAVAKATPGADQPAGTTAAGRRSKAPCARTRNIWSGWRRCRKCRPSQGQTSEEKEGSDHGSQDRGYTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXF0</accession>
    <name>A0A179TXF0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_02993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00536">
        <property type="protein sequence ID" value="OAT00536"/>
        <property type="gene ID" value="BDCG_02993"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02993"/>
    <dbReference type="OMA" id="KQDRTTY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="PTHR28086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="339" mass="38738" checksum="C685251F813F4537" modified="2016-09-07" version="1">MASTIKRLLDHLREAAFYSQKDLDSVSKTLDTMQENINRGKETCSPDILKLLEVRLETCRKQLAELQHELSFLSPELAPTHETLVSILRSTSAANTRSKFSASEVASFREQLKAIQDSMKGGNFVGPDGSIPEGQEIVKALLDRCWKWSEIVLERHGQIDERFKDPYIKLLEIRNQLDRLVMTQAWSLRETDLFMYQRKLNNIDESRVDGNFLDSDGKPADIHAQRTLLYLIRRSYAIIYGLLISSEPVSEALLPIYNQLQTLRKCLIEVKESGGVSNSRELYPYSMKLNSIDNMRVDGKFYVGNDLPEGQGSVNELLAQCYDLCYELRADTEESRDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXG8</accession>
    <name>A0A179TXG8_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease T(2)</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_01169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99748">
        <property type="protein sequence ID" value="OAS99748"/>
        <property type="gene ID" value="BDCG_01169"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01169"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="PTHR11240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="SSF55895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAS99748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="473" mass="52869" checksum="D75C63BCAAEF1325" modified="2016-09-07" version="1">MEVPGFADTGGLGSLVAALLTLGNLNLRTSSSYPHNSHHLPIAHRVFAVINMMTKETLREAFIAVARPLKLKLPSPKSVLRFASLGTSQIPLWNNQPVQQESEVAEFFSCPSPQLSCKVEFNSQDRCCFNYPGGQLLQTQFWDADPPTGPEEGWTIHGLWPDHCDGSYDQYCDSNRRFQNISSIIEESGQLELLDLMRMHWKDFRGDDEDLWEHEWNKHGTCISTLEPRCYPNYVPQQEVVTYFQKTVDLFLGLPSYEILSVAGIVPSDTQTYDLDAVEYALKKAHGHNVVVRCRNGALNEIWYHFNVAGPLESGKFVPAIPVGGPSNCPRNGIRYKPKNSSPRKPSSTRTLPKPTETPPTGTPFVGKGNLMVQYSGRQHGCIISRGSWFAAGTCATFRAFPYTEDDLYLKSSKGLCGFDDDDNFICGADIDEPTAFTVSDTFPLLMRLAKNYPSTNKLYFTQMPSRDAEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXG9</accession>
    <name>A0A179TXG9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00153">
        <property type="protein sequence ID" value="OAT00153"/>
        <property type="gene ID" value="BDCG_02017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02017"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="560" mass="63574" checksum="9061EF3BEE436133" modified="2016-09-07" version="1">MEREDVIRPSTAKSRTVYEQGFCIWTRLHTRARQEPSLPQTCFHIQPAVRQVPPLVHDLDLKCEYECLYATGTSIWETSRDQCKLPPVEKRLELPVSINHPTRLTLSKNLNPTYQKWFKREESHLSVLILAWSYIFSARWVELMPGAHLTYTEKHVEYDNKGDEQTQVMVDIGNVDDEAARWWAAVLSSGEGWQAYLTWEGAKFRSPWSTVLETRAKFTLACRKPLCHMSTTAASFTTAVHFLTEYCYLHNIVDQTLAALSSALFFPSLHTKKNPISLPKPNSHRRQRLKPAISEPTERKQLGSISEQIVPELDKLLTLSCNTRGLRTLLSSVFYEPGIPCNTVSFLWLGGIIMGTHKDVLQDGRFGLMPIDLHAASWCGVTQSFLQEPVSQPLITNGALLRSDECRLLYLTQAERHSQCPVSPWMPFGTTALEDTEIDVRLHTQCTGHGLQYADWYWACRNGKLVRPLCVKTTISAHLQERHPAMNTPIRYDALNLEDESASENATRNIFGCLRIDGYPPRERGISNHEWMNIDESDDESPSLNESPRSHAAGTSKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYG6</accession>
    <name>A0A179TYG6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99896">
        <property type="protein sequence ID" value="OAS99896"/>
        <property type="gene ID" value="BDCG_01514"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01514"/>
    <dbReference type="eggNOG" id="ENOG502S34X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEASMYD"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="PTHR16291"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="490" mass="55443" checksum="0998AA3706DD6F87" modified="2016-09-07" version="1">MEVASSLHPQPTNGTNLNPSMIDSSMDIDMDLDLGPLPEPEPEHVGIAQVPSVTAEEAVASSHLNEEPQFEKVHIRGVDELTTEDLKRYSSEHFVTEELTRIEWIDDTSANLVYSCTDIGLQALATFSQQNPEEDPSPLHSLRLRTAKSLSTHPESVLQVRTAVKTDRKRQRAHESSRFYLMHPEHDPRERMRREFADRRRSGRRDDSESDYTRRRFDDREHRRRRGRANEENLSESMYDDDGGRSRERSGSNEGRLNGDRGRDRSRRDRRDTIELFPDDGPGSSGRLRDRSASPLRMEFDQDSTLDSRERTRKSFRNRSPRNSRSRDLMSRANEYATIDDGSGRPELFPNKTTSSYLKRELFPKKSTSSNHRRSDAFDAADETADLFPKHMPVPLMDGASGGEASGRSTGPVELFPDKSDNNGMSIHVAASEDQGISIRGAAQGISIKGAASVRELFPSKYNSNEGKELFSDKLQGRGGKRRKAEDMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYG9</accession>
    <name>A0A179TYG9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_03861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00916">
        <property type="protein sequence ID" value="OAT00916"/>
        <property type="gene ID" value="BDCG_03861"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03861"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="694" mass="76423" checksum="E0C50F4B126CB847" modified="2016-09-07" version="1">MDHATSHGSDHSSLTDDEDGSSGTGVQVSPPSATSSHDHYDHYDVGGDWAHLSYPDELKPSDSASRARTSNRHRNLDNSRSGPSRRHSSRRHIPQEREPVVAHRPRRHHHPPAPASPTESVDSADEYDYPPPRRPPERQYWASHAPHPPPPGGYARSSASAPSYNPYPQQGTMPHGVMQPTHGGHPGMPSNQLVQLGHMGHMGGMNAHMGHYPPGQQHHYPYGPPPFSPHPQVQNHQMPPPFFNGHEHPMHHQPVPRQRHHVHHHRRTRSQSRPPPPPRDESESPSPRPPHAHPVPGHHHPPFPPPQFSPVDMVPYGIPPSGLHGAPHGGPHGGPAYFPPYGHQFPPLPHGMPPPHFFQQFQRQPSPPPKEPTPPPPPAPPQPDPKDEAIARLEKLILEERMEREAKELAREAAIEKAARDKALAEERAAIEKKIAEEAAAKASKIAREEAMKEAEIKAAEEAAKAKIAAEEAAAAAAAEATEKATAEAAVKTAEAVAAATAAARAPSTEKKKPVKFKDAIGRKFSFPFHLCNTWPGMEELIRQAFLHVDILEQHVAEGKYDLVGPNNDIILPQVWETVIEPDWAITMHMWPVPEPKKSKKPKNPDPPEVLEDDPNLVTIMDLKALADGQLPPPPPGPKKPRPRDPNPGAFTMWMMGGNRSRLPNKPLKAEKKLEVIPQPQLHSSMMNNAVSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYH2</accession>
    <name>A0A179TYH2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_02914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00493">
        <property type="protein sequence ID" value="OAT00493"/>
        <property type="gene ID" value="BDCG_02914"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02914"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="PTHR35895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="782" mass="84883" checksum="51A029680F97179F" modified="2016-09-07" version="1">MAGDAAGECAPLLSEASQENLHPETRTSSIRNGKPKTTSYELLSESTPLLAHRASEGIQYLGDVNISSSSSRESSPNPSSTKQGPRWITRPSSIALLSLILAIITVLGLGFASPTVIKQYAETATVFKATDVSIDSFTSDGVKARVQGSFVLDASRVPTKVVRDIGRLGTWLAREIESDETEVQVYLPEYGNVLLGTATIPPIRVNIRDGHVNTIDFVTDLKAGDMAGVRVVANDWLQGRLGQLRVRGVASVRLRSGILYLGSQTISESFVFQDHSYHGFPDFNITKLDFHEIRTPTHQKAMEADISVLLMNRYPVKLTVPPMGFKISVPNCAPMDRYIVVANATTDLVQIAPNEPVNISAKGYIGRLPDVLTTACPGTNWSPLDLLVENYIRGLESKIYIRGGKSPSSNLPNWIEGFLRNVTVPVPFAGRALGHLVRNFSMTNVHFFLPEPFAQPDTPEAQLTVSAMVKAVIGLPKEMNFPLNISHVRSTAYIYYEGRELGYIKINKWQNASATRIQDGSPPSAALLVQFDIKKAPLQVTNGDTFTDVVQALILERKPIPLHVKAKVDAETDTALGQFIIRDIPASGNITVKPLASGGFSDLKVAVDTLEIVQTTESSILLAAKLNLTNPTEYSAIVPYINLRVAHNGTNVGRVIARNLSMSPGLNSGVEISALWDPLRFGGKDGIAVGQDLISRYVSGFNASIALRPHQHTIPTLPRLGLALSALELDIPIPKLRAPRDDQNPGDDGQTHFIKDATVLSALADSLSKQSPTEEIRQMGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYH7</accession>
    <name>A0A179TYH7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-interacting protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_03202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00620">
        <property type="protein sequence ID" value="OAT00620"/>
        <property type="gene ID" value="BDCG_03202"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03202"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051125">
        <property type="term" value="P:regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIP3" evidence="4">
        <location>
            <begin position="556"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1091" mass="118904" checksum="59BB4604FD3CD7D0" modified="2016-09-07" version="1">MDSSSSSSQSRSRRIRSPAFDRARSPVVQQMPSASLSSGGGGGSGGGGGASAGDAANMSQPVGTRASSGSGKSSLSRSAQQPDKQLSQIEKSVTHLLVATKQLLETLTQWSRQRASESEVSDVYVRLGYEFNLACRAFGAIGVDTSDLGPVPDLLRTILEDTLSQNASPESLDRYLPRIRDIIINLLQGLKKKQAKLRSRQMKDSLPRTARHGSAGSVGSGDNSLNQTMDETPSVSQLPPKRQQELSRQNNAMKSYGDTGFSRNNSSSNWSNDRHGQSFAEREASKRDPQKSAASSSSSLSSSAMQNIPVMPTYPDQSMNGPRYDNPPSFSAHDFPHPPPPTPPTSKQNDAIGMLQRSGELERRASRRFSAYQIQKHLGPSPNGVPVIPSSQNSPVPNRGRDVRESMNAVRLRGSYLHSKQRSNNRTLESALGQTTSSPDRREPVKKPQLDTSVASTEDDGPLPKTPTDKLGSPRRYESRDMPTVGGSLPALPHILERDSGSETFEGPPGKSTGQQSAPANGTQHAKTASTSSDNSPAGQFTPESSPPPSKEITLFLQYRSKIKKYVLPEGYSELTLGRLQLAFIEKFAWNTHNNGVDLPEIYLQDPVSGVRHELEDLSDVKDRSVLVLNVEPLDEVKKHFDDGVGGLRRLIEGVREIVDGQGTSIQRLTDRQSEAAKEIARLASAPPPAATSKSRVTSDGPMSGGGNHIAELQDIRRDLAVLRQTYTSFTVDISNSMGSIRSKASSVKNAANEMTVPSFEGDAGRARVNAGKKELADESERIVARVDDLQDLVEDLRKDVVTRGVRPLPRQLEAVGRDISAVTKELKKMQEFLKREKPIWTKIWEKELQLVCEERDQLTMQEDLVIDLEDDLEKATQTFGLVEQATKQQSLDSNSNTTPGPHGLRNVSRNFPIDEPLDPMKAKDYLLGEVRALQPNHENRLEAIERAEKARQKELETRRVGPLQKELGKFVEEGKLKKSGGFEEIERMRKAKEDRIRKEVWERMNGIVPESEQNVEAATSTATSPPPIDDKPPEVDNPESAKTVGPGEEHANPSSAGKRSGARGSGASDGPAPTKDEAAKSPKSPTAPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYH8</accession>
    <name>A0A179TYH8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_02926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00503">
        <property type="protein sequence ID" value="OAT00503"/>
        <property type="gene ID" value="BDCG_02926"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02926"/>
    <dbReference type="OMA" id="TEIGTCP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT00503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="646" mass="74291" checksum="DB8E7A61459F7F7E" modified="2016-09-07" version="1">MLTLGGCEGMKEPGGDEEKVTVTTDAMLHRFDRDRAAQAAAAEIVPKARAKRHAATLAAMRRLYEERNSNGMKNLLFSTIFNGYTHLPSDHDLHDLARYQFPPRALLEAQVCDFYPDHAEVKGVPLGDIESQWQDKPHGVQVRWIHVPVGRGIYHSSIEDLFRHASNEHPRPFNNAGHVGFAYVELDNLNFRHREEVEDLRDTYCLLSRLEHLSTSAPDYKGDGLSPQTTETSVGPEPLDWECHRGDRNAKLRADLEWRADHLNTELTFWELVASDIPWQISDGLPICASGPLGRIKPVINSYDFRVLSSHPAFLDAQLVRNEFRFFHRNDGFLLTLSAAKGINYLDARLQEYLRQSPDDILRNPGASAVGQTLKEFASTGTSTWEKPTAEWLVVHLATEIGACPHNDTLGHNQISIVEAYQDILRDLKLRTYEPWRRDETVRLTRTFLQCMEEIRFISKMLESRQSLFTRLKEDVRTHDEEDRNNDIPHNPGGESCMHRVDWALGKIRQQRDDIENIAHEIKNSMDDLLHLRTIEQNELTIVRDSQQRAIMLFTAVTVIFLPLSFCTSYFGMNLQGISDTARSERYFWYVCGTAGFSIVSVISIYAFWHPAKDHLMTLREHRKSKRLAREERKRRLKRRISSENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYI5</accession>
    <name>A0A179TYI5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00630">
        <property type="protein sequence ID" value="OAT00630"/>
        <property type="gene ID" value="BDCG_03227"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00631">
        <property type="protein sequence ID" value="OAT00631"/>
        <property type="gene ID" value="BDCG_03227"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03227"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="452" mass="48852" checksum="91EB964CD4ACCDE4" modified="2016-09-07" version="1">MCREPHAACASSSGISTAPLSAPTAMREQWPGHNMTPPGSPSLPLHIASQLHGGDSAIYELQAPFNYDEPSVSIAPAVETTLHPAEIDFAWLLDSSGPKALTGQIPQDASHMGFDSTSLSSSPAPNSAPGFSEAFTSPSDCSYTGDMNSPMYKLSKLHLELDNLLSLSINCDGTVHPNDLMSSPSSPFSAAIAIPTTPTTPTTAIDEIFLLSETLIKIVQELYQEATTTMCQPLSIYPFTPQSSPLRRRGSSNSQDSYKSGRQQEPATILLTLTCYLRLLGIYETLVVPLYQYFQQHRPQFKAHPNSSFPLPLPLPIPSLPTFKLGRYGLTATSSMNLGLLLHLLLRTLECLHSTVSLYLSTTSPSPHSRWAYDGNAPPSSTKSPTSASDYAESGFISPMRDNGQHDDFSASLGIRDHVTLLTESALSEAGRREKYLTGILHSVMETLPAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYK1</accession>
    <name>A0A179TYK1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAS99700.1"/>
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        <property type="gene ID" value="BDCG_01078"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01078"/>
    <dbReference type="Proteomes" id="UP000002039">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="562" mass="60536" checksum="98683724FD9CB696" modified="2016-09-07" version="1">MFRLRPTHIVPSDDEIYSSVQRILVARILERGGDLHVSPHRQRQSSSEAAPMDSPLLALDSSSFEEFTDCGPDDCDSSPSLSSGKGKRKTSSEETHHQLSPGHQEAPPSGTDDTRLAEQLETITLSFTSFLSPSIWLGPFASSSGPVGGNLCQERGDDFSTTPFYPMKPMASFLIPPGFPPLKCHALYSDIFLCSEESNKAFPVLGCAITGPIPPRSARCSSPYFQSIASTPSLSHSQDTDLESESQDGFTSSNPGSNRELTTSLYGIDPFFNHFGQSPATSDANCGSDNSRTVKKVSNVNCFQCQWHCPKGVPDNSYASAITSLSCYGFDSIAPEEVASSQASQSGSSSPDQSPATPASSVEGVSTVSTSRNPTQGYPIASSSIVTRTGRILLIAPKAFADQIPQIERISQEAIGLPQVPQSYTFFTLPWLTLQPMTPTYPVLTPANQPQPAIPLRHTGINYYHVPLGGIVRNPIPPSPALNQEQQQQYTEPTTNSAYPTGHGYLVQQAGQQVHDNSASEPVTSRLPAGSFQMPLGVRWRIQQFNWAPDPTSHPGGGPNNM</sequence>
</entry>
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT00956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT00956"/>
        <property type="gene ID" value="BDCG_03921"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03921"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="180" mass="18942" checksum="A61D1B9E55EB58F6" modified="2016-09-07" version="1">MWGNGAAAARVLAANGAKDADVTALVDACLARYGGRIDILVNNVGRSEPAGPAEMSEQSWDSQTTVNMKSVYLCCHYVLPIMEGQEGGGPIVNVSSIAGMRYIGKPQVAYSAMKAAVIQFTKTTAVIYAKKGVRLNVVVPGLIHSPLVGLLAEKYAGGDLEGFVEKRHQACTDGEDGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYK8</accession>
    <name>A0A179TYK8_AJEDR</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BDCG_02990</name>
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    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
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        <lineage>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00533">
        <property type="protein sequence ID" value="OAT00533"/>
        <property type="gene ID" value="BDCG_02990"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02990"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="71" mass="7807" checksum="A1FD945A21FADEB2" modified="2016-09-07" version="1">MNITITRGVNDVTDIIITITTNIDAKTMEIPITMPGPSAYMMPGHSAYDARPQCLYDARPQCLRCQAPVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYL1</accession>
    <name>A0A179TYL1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RTA1 domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
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            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00139">
        <property type="protein sequence ID" value="OAT00139"/>
        <property type="gene ID" value="BDCG_01980"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01980"/>
    <dbReference type="eggNOG" id="ENOG502QU4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PTHR31465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="289" mass="32158" checksum="7F43C02006E4073D" modified="2016-09-07" version="1">MLMAVQFSDEMAARARALCTEITPQCPVEFTTLGYFPNLGANSFFCACFGVFFFVALVVGVWKKTWTFTFAVTGACALESVGYAGRVLIYQNPWGTGFTLQIITIILGPTFLCAAIYLTLKHVALAVGREISRIPPYLYTWIFIPCDILCLVLQGIGGGVAASGDQKKDKGLLDNGNRIIMAGIGLQVAVLSLFGTAALDYYWRVSRYHRKLLATDEERAAWRDRKFHIFAGAVSMAYLTIYSRCVYRDGWRLGVSTHKKWHRNVCAGANRAPEIPLCETNPHSLLWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZJ4</accession>
    <name>A0A179TZJ4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00277">
        <property type="protein sequence ID" value="OAT00277"/>
        <property type="gene ID" value="BDCG_02361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02361"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="717"/>
        </location>
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        </location>
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        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
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        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
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            <begin position="176"/>
            <end position="205"/>
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            <begin position="273"/>
            <end position="289"/>
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            <begin position="671"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="923" mass="99338" checksum="22541E7284DDA67A" modified="2016-09-07" version="1">MDEEERQRRMQELQMADLGSARREYISTVDDAPNKYRHVGLDQIEAMRAANMKGSKVQKLAEANKTQLSAWNNAHQTIGGDVQLEDLDSMMSGQSHRAQLCDLIQSKGGQKYIHGPTAPPNGRSRSTQPPRGSRGIGRGGGVAGSRARGNFSRTSFGPQSTPSPCVLGSGGGHAVESTPDRRRCLDPARSDAAENFREKDTKIGKAGVTPRTPRSDRGSGGLGRPGMVKTRRVVDPSANSEAMFADPSDFMAVAKVHNASCPSDPPKPTRNAAAQPMTPSNQTKQENAAKEEVCIQEGASHNGVLEEHIKGGTQKRKNEDTISATLANDLQLKGTILPEHDAKSTSGNTWAIQVDSLPSGGIGPGQTDFGKLKTDKRFRSSLPQPIHASEESTLLIDLMRKSRSPSNPASAIRPRHMDSGNIAPMSSFLTNTPPSMRMLLPEIPTSSAGAKAVGNSQNGTSNAALKAALDLLIDRLQRELHQVNQIIEDTPGPIELTGIGIYLLKRKQQLESEIAEAIEMESDIVLPFSALTLEDPSHKEPNEEHNVSQEMPIPKVPVVSMDKKEVAPLIPGSGSTAMSFGKPNVGPQEVLLMSNNTPPIPTPTLSTFTNSVHDIIGDHLLPGRNPSSIKSDLETPKVLSGNSSLHDFSTPPAGPATGEARPAPHGAVAFDHSSSVNQLQVRDTPNIPDNAITRQYLESTSETSKRSTEPRNLPLNGQRNHHLLTATQQLSSFAIHPLEQSSEPPSPICYMTAVVQSPVAPYQPKPAPQGPQCVSSPGLGVPPKPSEMKPIARNFAPKFPMSAATMQYSGALFQRQEQNAVPKSPDTTTPSCHNPPVDPSKPITPAFVSRFPVSAATLQYSGTISHASIQATDPPPPAGQEGRNASTWTRKFQMGYTSRCTYFTQRGEQGTAITQTKKRWKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZJ9</accession>
    <name>A0A179TZJ9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_02859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00459">
        <property type="protein sequence ID" value="OAT00459"/>
        <property type="gene ID" value="BDCG_02859"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02859"/>
    <dbReference type="eggNOG" id="ENOG502RM2Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWRRSKH"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="288" mass="32212" checksum="48CE9EE955DCDDC9" modified="2016-09-07" version="1">MYIYPFVRIGNKKENESRSLFTPTTNYKPKSTFSWTLPNRLPTDLFSTVQQVLSEVQEARRLKQQVDSLLHPNERQWIDTTIAETDTTANEIAVLLEPRRVAREIGQGGKIGLRNRLRWALRDSHRAKEKTSQLVLSRNSLMVVLGNLHMRGSTFSPASKPSTPKPPSITTITSPAELDSLSIFAASRKEGCEVKVKRGSSLSDELNEILAWRRTKGAWSISNHELTGFTAVDSTSSPSYFSTHSTTNSRFPLALTETRIGKATMQIKRKPVPAGPIPTIEEYGSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZK1</accession>
    <name>A0A179TZK1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BDCG_02828</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00448">
        <property type="protein sequence ID" value="OAT00448"/>
        <property type="gene ID" value="BDCG_02828"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02828"/>
    <dbReference type="OMA" id="FGIWVAW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3-di/monomethyl-lysine-36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="360"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="20">
        <location>
            <begin position="615"/>
            <end position="773"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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        </location>
    </feature>
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            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
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        <location>
            <begin position="962"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1118"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1351"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="962"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1118"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1136"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1179"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1237"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1265"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1300"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1368"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAT00448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1382" mass="152666" checksum="1E98FECC3A2AFEBA" modified="2016-09-07" version="1">MANTSSFRNPSRVRPSRYRTPSPPRHAIESISPRAPADSSSSSIRNTHPSDGVQQPRNDPPFVEKGSSVKPGWNNNTFQDGRESLDHRYSHHPPGGSSSNHANTNPTGRIGHQRSGSNIDTLATIALATSPTFAPLTYDEPATAISPTTHQAPAPDQSERPSKRARSEKAPSPTWLMGASRPATSHVSTFDSMKTDAELLLNFARPSNFPPLYDASRPQQLAAHESTNGQNPGVKWATDPAELWTKRWDITAENKPSSAFFRSNNNGTPSRIRSKSDGSAFTARPFMNGFASGHFLAPSIGPALEDDSVDPHYIAEENHDTTLQANGPDTQQAPRPLQRPKSIPASDFKEEDSDNDSSGQATCAACHLDRVASDSEGDEAVTWINCDGCMRWFHIVCAGFKSDRDTRTVDKFICRGCRPTHGPTTFVRKSSRARTAIDYASLNQGYVMPSAETPEHHYIQPIKEGKITFLPDHFARIRPELVTAEYFERGIGMTEPIIIPASLNTRSSVPGSADYYPPEASTQEEFDELADNMPDDDADYNEVIDCGQDLLDMVIPQGLTVRHVAELYGPEERVEVIDVKSQQGEDKRWNMQRWADYYYDDSTSKAVRNVISLEVSNSPLGRLIRRPKIVRDLDLQDHVWPAESQAIGEFPKVQFYVLMSVADCYTDFHVDFGGSSVYYHILKGKKSFFFIPPKDKHLKKYEEWCNSAAQDTTFLGNQTKECYRVDLSAGDTMLIPSGWIHAVWTPEDSLVIGGNFLTKMNYGMQIKIAKIEKDTKVPKKFRYPYFQKIMWYAAIKYLEDDPIPQTVLESFSRDENYRFYREYPIYYESGENDNRAEPGSQNYNARFYSQAELDGLPELAKYLLRTALIAGGYHVDGVTTETRNAVKRSIPKGQADPVDTIIKFGVWVAWKRGNEHAASWTRPGAISLDTKVDMSGRKPTVRPSRRSQRNIAAESLQLNNNLELRAGRRPSYQSSEINTSGMSSTGFTSTSAPSTSGTPAPPKREASLVDVDEIIQSNKPRSISKPTGLGPKRVACDACRKRRIRCRHKDEQSLESFTSLTAKQQPLNGKDMAAAGALNLASAAHVDRIKEQHSGKWDEMLPNAMDDSSALLMTPQANSAKAKGFSPNSSNSGKKGRSKACDECRKSKRRCIHDENGRIDPIKAQERSKPRAATSTKRPRSSDDNISPTSNKRQKPEFEYSGEELPQTKLDFEAVQLQGRMNGPNEKLGSGDKVGATAHSELTQSQTSYASPPTLKADLVPPSEVTSSLPATTAPASSLVSPPTSLADDMEVDPNQTDGETKAAVKNEQQQQQQQYGELSVVDDATATLSRNSSSHPRLVPEATVLAEEHKTTATAARAPPATVTVPSDLKPSLSSSQPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZK7</accession>
    <name>A0A179TZK7_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_04004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT00980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00980">
        <property type="protein sequence ID" value="OAT00980"/>
        <property type="gene ID" value="BDCG_04004"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04004"/>
    <dbReference type="OMA" id="IITTFTW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT00980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="451" mass="51016" checksum="C4475776B15F87DE" modified="2016-09-07" version="1">MALLQSSLIWIVYAIVVVILIAVASIFFYTYQTPRERSASVTTACIFTLTALLATVLLLPVDVALVSSTNLPKEGRRKSWATQDEVDKITFSLTVTYYFLYSLDAVLCLVVVPFTYFWYEEYDEVATEEGLQSWRKRFWGAFKYTIAFILLTVILFLVGFFVPVARNRDAPNFDLDYFKKLLTENHGERALTFALGLLITIGILVYVLYTSAGLALLPVTFIKSAPAISSPTLSANTASRLEENIERQRQLEGRCGGDPDRLPSKQRRELDSLVREERTLRRRQRLSEEARRERGSWLLKAWFKISAVFRPLKLLGGLLLLAIAMLVWVSMLLTSIDKVMNSVCKQHCGYILGKNNIFNPVNWVFVQSAKVFPVDYILFILLVLLFFCSSVVGIATIGVRFLWVRIFQVRKGHTSPQALLIATVMLTLIALALNYSISMVVAPQYATPAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZL2</accession>
    <name>A0A179TZL2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 finger domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_04903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01326">
        <property type="protein sequence ID" value="OAT01326"/>
        <property type="gene ID" value="BDCG_04903"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04903"/>
    <dbReference type="OMA" id="MPAIIHL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="519" mass="57310" checksum="81A3A727961A8865" modified="2016-09-07" version="1">MESRTMPPEPGNKRPRSPSGDYTHSTPSTKIPKTHSNHLQINYLARQYAHNIPLVSAEDTLPSILRIINDYDGVLQRHESIAGNLGACPLGPILVSRFERLFDGPPKVLKSHGKEGTTVSWLDVVEFAKNKPEQFTLEKTRNGVPVCQIYTKQSRIEISEEDYILIKSGIPQKIIPPQPIVEDEEKELGALEILEKNLGQIINLADQVSARARQLNHRFKNRKSAIVSRRENDLSLTARQPRSISPLREANGNGMGTAHTSNGHSSPHSPQGFIAVNSSSRHEHSPDDASILSAAQFMFPHSSTDNVTIINGTSIKGASPATRAELMKKFFTTADRHARGYQNDEVIEGPAPPARHTSRSRPRASDPGEYGGGFAGSGPVAIPNTPSSLLPQPKSSNHYERDDGGPYKIEMVSRMEGLQRGERILPPCDRCRRLQMDCHKNLTACMGCTKKHAKCSWKEVKIEELHETYLARPQSSIDGGNGNMHDGTMPTIETEAETSASASTTELGPYYLQPQQQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZL6</accession>
    <name>A0A179TZL6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen permease regulator Npr2, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_02877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00468">
        <property type="protein sequence ID" value="OAT00468"/>
        <property type="gene ID" value="BDCG_02877"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02877"/>
    <dbReference type="OMA" id="YASMTHG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="PTHR12991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="473" mass="52674" checksum="6B93A812CB251520" modified="2016-09-07" version="1">MTSPKYDRNEFIFNFCIVLAEDEEFGTFKSVVQKLAHLMCGLEEQSGFLSKDLSKGGEGKVYSLCETLMEDLNNYCECMIPIDELNTLNIKLFPIYPSPPMVKAWHVPLFTVRYEAFVDENWDLTMLRIVPFINGVNSVRIISALADTDFSLTCSAIRHLIYYGCIFLLDIFSFTAIYAPTAQFGSTIAVDEDMQRECARYVNTRFAPTPSITAPPTVTASTQSTVSSSSRSRSKGRRDDHVDHDDIWPLVANSGTASRDPAGQRASIVDGVGLIELYASLRQGKTVKQWYIEHSRELANIDLRRFITFGVIKGFLYRVHKYAFATGYLAQPARQHRHGLVLSSSSSSFSQKNQSESVASGGSDLGGAGEGGGGRGRRLSTWSRRSISSRDGSDVTAFSTTSYTNDDNAVDDDRDDDYALGGEEEALIDDKTLGKYLDGAHCFDQICTELEISEKELTDRLKSYPFEVQIIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZM0</accession>
    <name>A0A179TZM0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMGC/SRPK protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01364">
        <property type="protein sequence ID" value="OAT01364"/>
        <property type="gene ID" value="BDCG_05008"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05008"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="324" mass="36367" checksum="626A4DA6EE5528C6" modified="2016-09-07" version="1">MTTTWIISRRTVPLRNISHFCIISKSMSITGTHPGKDQPALHYISSVDAEPLRRYQPGGYHPVILGECLKAGRYKVLHKFGWGGFSTVWAARDQRDETYVAIKISVAERDHDAETRELQIMKQLSTLHPCLKYVMRMLDDFSLKGPNGSHQCLVYEPLGPNIPDTITAHFPSGRLPGKVAKVIAKQCLIGLDGLHQQNIGHGDLHTRNLAFTIPDTTNLPEEKFVEMLGEPEVGCVERRDGKELEPGVPEYIVRPSLHLTRLWNSTPIVKIVDFGESFLPTTVPQTLHTPLSVRAPEVIFQDCIDYRVDLWSMGCMANRPSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZM2</accession>
    <name>A0A179TZM2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00081">
        <property type="protein sequence ID" value="OAT00081"/>
        <property type="gene ID" value="BDCG_01878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01878"/>
    <dbReference type="OMA" id="DNQPEFY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="457" mass="50947" checksum="B6FA26CFEB7F48C8" modified="2016-09-07" version="1">MSVRIHLDRPHAYFTNLDFITGKVILALSTDTPVSSVVVKLEGESSTRLAAPKYPNSDRSEKKRTEVESHKLLYKTRTLFPVEDTSELVGSNPYYTLPSGHHEYPFSFKFPFNNDCSEHARTNLNMGAIRLEVARDTNIHVRRALPPSLTGFPGEAEIRYYVKATVARPQFYKENYRGFADFKFLPIEPPERVVPGAESYARRQQQFSKVSSIPGKKSLFRTTNPPPLIDIEEEPPKFSVDARLPSPAIITCNEPIPLRILVRKLNDSSDTIFLQMIQVELIAYTHIRAHDLARTESGSWVIVSQSNMNIPLGDGTAPAGKEWKIDSSMWDRTPLPSSVAPSFDTCNISRTYNLDVQVGLRHGSSAMMKPELIVVPLRIPVQVYSGIAPPQALLDAVRRSPSKVSKVSEVPPPQPPRPEVVPTIAPVHTEYDDAPPSYEDAMADALGPVDGPRRDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZM3</accession>
    <name>A0A179TZM3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein Dds20/Mei5, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01336">
        <property type="protein sequence ID" value="OAT01336"/>
        <property type="gene ID" value="BDCG_04946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04946"/>
    <dbReference type="OMA" id="YAEYSID"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="275" mass="30469" checksum="08F7DDD854F3A2AE" modified="2016-09-07" version="1">MSFHAAKRRRLDQATHTLSKPFKSPLRKQIQNTSAENGDEKADGVSKSIAPVDDASHNTTISAGAQHSPHTPRPASAAIKRPTTIPPTPPPTISTPSPSAPPELLALQKQYSALTTRLAKLRMDLDIVTQALKLEQSGKDAELEVLVAKWKTASREAAEELFVGAEERVKRMGGVKGWRENMRKAQERRTRWDEDERDVGGKDEMGSEGGEVERRIAEMEGEIEGLERRSDGKDGNRDKIGEGDEGESFTMDMMLKSLNIELDIIGFDKDTQQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U030</accession>
    <name>A0A179U030_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_16889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01073">
        <property type="protein sequence ID" value="OAT01073"/>
        <property type="gene ID" value="BDCG_16889"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16889"/>
    <dbReference type="OMA" id="MAMINLC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107133" evidence="2">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="316" mass="34835" checksum="1337954CD36D32B9" modified="2016-09-07" version="1" fragment="single">MINLCLSLVAIWSLPSVVSQSGALKPWTCRLIEDIDWFGAIIISVALGILLYVLAMVSSSYRRASGPQNIALLTVSCVLLAAFPCWMHYQVKRGKPALIPNRLWKRAAFTSICVSVFFCWASLNGIEYFITLYGVLPTSRGSFRSSNFDPLPCTRRNGDRSQHCHGLPYLSRRSPHSRCRFCSNYYGCSDSYMATVEVGENYWLRPFWALLLSPVNPDVLFTVSNLVILDTFPAEIQSLAGGVFNEVSQFGNSVGLAVTASIAASVTEHSGLEEHRAALMEGYRASFWTIFAATAIVVVISFFGLKKGGTVGKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U040</accession>
    <name>A0A179U040_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAF1 family ribonuclease, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626645.1"/>
    <dbReference type="EnsemblFungi" id="OAS99761">
        <property type="protein sequence ID" value="OAS99761"/>
        <property type="gene ID" value="BDCG_01198"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01198"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="541" mass="61586" checksum="CAB531DFAB371C59" modified="2016-09-07" version="1">MLKKNIGTYVLRPYNLHINPVLDERLGVERRWSYQSRAVEFLIKNGFRMEAPFVEGLPYLSRLEEQLAMTKLAESENSTAKIADIKPENMDPESHTFVAKVRGLIDSWIDEIGDKEEYLNIPEPGGLENGNMAGPLGSWRFALNSYQKRLVHQLVRAEYPSLVSISRKTFVQIIPYNKQREEYIRVDKWRTLRERIVQQMGFRWIVEGMVGGDLSAMDPRVFLPCIPDSATVDAEALSNYSDDLRSKLKSRQPVLVGHNLFTDLINFYKCFIGNLPDRIEDFKEAIHSLFPLVIDTKYMATHNCSSVTPSSSLAEINDNLAMRKTPKIFIDPEHDKYVGQKPLHEAGYDSLLTAKVLIKLTAELQGEAPIANVPRPCIAQPVVLDDWPRAPLRTASRMRSRVENKAKKLIDIGEPDCSDSQSFSSSTSIFDRRSSSELVAISTPKQSPVDWSTESEVSRIRSLLSTPTQSEPLAGRTHGTDKSQPPFMDPSSPFWKLQERAMIQHKRKRARLIPQFLDDFWGIYGNKLRVFGTLEEICDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U044</accession>
    <name>A0A179U044_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">White collar 1, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">White collar 1, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05371</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ER-3</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002620681.1"/>
    <dbReference type="EnsemblFungi" id="OAT01506">
        <property type="protein sequence ID" value="OAT01506"/>
        <property type="gene ID" value="BDCG_05371"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01507">
        <property type="protein sequence ID" value="OAT01507"/>
        <property type="gene ID" value="BDCG_05371"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05371"/>
    <dbReference type="OMA" id="DYRRMEL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT01507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115964" checksum="152F057A1FE5E356" modified="2016-09-07" version="1">MSSAYASTRLPYEIPHIGAGAMDQSEGSQPNYDHSEKHVNYSKQYTDNSLSGLHSNAADLTRNWNFERAQSVEEGDAIESRSQGLHRENSIQPLNYETPQNVTLEIAASAPLEYGKFAPPMQLECFQASAGDSATHLDSSHASTHIMGGFRVNGAPQFYSTSPTFYPLANAASTISGITPSSEDPCNYFGYPDAAALSFPDPSVSRFLGLPSLATGGFPAITPSHSHMVDSKSLTEAFQQRELRWCRNLPHNRPPYRSQRLLQPDPSKNIKNPQPPYYPHEQNRPILQSSNGFSAPEPMKHPDMVPPQDSIWMSRSNIPNDFNNPGGRIVSDLKVCPDIAFTIEDQDGSSILPAPLPENVTYQYSTNYPAREPSAIDTLNYIATRPNPEINLGPIDMSCAFVICRITANDCPIMYISDAFSRLTGYSLEESVGRDCRLLQEPTGIIEPALRRRSVDDRTIRHLKRKINARSEVQECLVNYRKGGQPFLNLLSVVPIRWFSDEYNFCVGFQLDLVDSPQAVTGKNCDGSYIVNYRRLELSPNIYDPGGMTSSQNKYPPFKYQNHSNTTTDRANGQSPVPLGTSLDEAILGSSEFLFHIMSTTGVFIYITPSTSAILEYESKELNGSTLSSICHPSDVVAVIRELRDREPGSVVNLLFRIRRKKSGYTWFESLGSVYIESTRNQKHIAFLGKLRVVFAMSRDELMKNGGINDGEIWAKISPSGILLFISSSGSAFLDRRSEGLVGERVQNLLSDDSRAEFENALGIARSGKRVTCKHELQHRRGHLLQAQSTIYPGETPCGSSKPTFLILQIRLLKLGRPIFSFQANATTTRTRKKLNSNTTMRPSIASDSHPRPSPALTRPNHGNRNITTSQSSSIYTRQHTTMRPYLKPELTNIATHNGHIPDHSLLCRQWEHETAGKAIRESCNIFEELNPTRATNWRTELDHLKRRNRLLVEELHYLTTLKRRRKRKRDVEVPEKDCSQCHTKTTPEWRKGPSGNRDLCNSCGLRWAKQNGRITTMPRKSSLRGTKPVEASKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U061</accession>
    <name>A0A179U061_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01543">
        <property type="protein sequence ID" value="OAT01543"/>
        <property type="gene ID" value="BDCG_05469"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01544">
        <property type="protein sequence ID" value="OAT01544"/>
        <property type="gene ID" value="BDCG_05469"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05469"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="299" mass="31995" checksum="98BEC0A6F9E82096" modified="2016-09-07" version="1">MLEAGSDEIPFGSRAIERGIEVEGIWISNPNTPAGSPIWGPTPDPSRPASLGSKSTLACHPPLPSRRGPDYLSPKNATLGRSKPASVSSPLPYPGVHNNANASSSGTKGRRAKSEFVPRNEQESEAESHTPQSDNGYSEFEFGELGGGVESSDQQQESGYSSINSRIAEDGSAFEPQESSFITPIATASENNLHLHGRSVESESGALEYVSGNAQLRSASGPPYEQAHLNSIENCRTVDDQQHSDLLPLHNRRRFSIAETGQFGNGRSGCVEVDDRDDEYDHAHAIATQFRGLPAAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U063</accession>
    <name>A0A179U063_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dual specificity phosphatase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_02890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00477">
        <property type="protein sequence ID" value="OAT00477"/>
        <property type="gene ID" value="BDCG_02890"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02890"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="277" mass="29928" checksum="C3062C86BF7ACAF3" modified="2016-09-07" version="1">MGKSRSATVCIAFLLHRDPGALTPWGALELIRQSRPLCEPNGGFQEQLELYHKMGCPDNVTDHPLYKRWVYERALEESVACGRAPEIELVRFEDECAEPSNKTDESTEIKCRKCRRKLATLPFIIPHTPQTDKRLPRGHTIPEGPCAHIFLHPLTWMRPSLFPEQDSSSPAANSADEYKYTPEAPLSGRLTCPNSACGANIGKFAWQGMKCSCGNWVVPAIGLARARVDVVDSVVRWGTIDASAGIRVPARIGGVAGGGVGGGASTAADPAGGRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U067</accession>
    <name>A0A179U067_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_03346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00679">
        <property type="protein sequence ID" value="OAT00679"/>
        <property type="gene ID" value="BDCG_03346"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03346"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="294" mass="32697" checksum="F731E95ECBC388DE" modified="2016-09-07" version="1">MSLDSRLEAEEVGGECTSEQRTSSQTDDVSNPVLSNTLKRKPSVDNGASRPSPSKLSRVPTVPIFASTELCSTAFPYLNTPTTSNANTVVDVTDNPNNHNHRNNTQVSIFNSRSTWMDLRDEDILHMYHQAKKCTEETRRAEALELKLSSSNDILTRCRDENRALLDLQKQHDDELEETMGNLLKERKAEQKQLKADNEAKLKLLEQMDQLKTEFNKIKVGASKVIHPGMWKSGGMDAAAAQVIKLAAQIEETLKVIVSSETRSPSQVPSGDHMFLGTPYLEPRPFLEGNGMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U085</accession>
    <name>A0A179U085_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01564">
        <property type="protein sequence ID" value="OAT01564"/>
        <property type="gene ID" value="BDCG_05541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05541"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="PTHR22792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="683"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="780"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
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        <location>
            <begin position="453"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="879" mass="94601" checksum="A38AC6C4AA97192B" modified="2016-09-07" version="1">MSTSTSRPGLEMPAFSYAQAAKGFSTPPSVQIVAEKQNKSSTTSSDPSSHRTATGSVDGDGSNRTVASSTDLESSSVATEPADATDKSQSSSERSSDWTVTPPAAGAPWKTATSGTSSPSVGTTSTTTLPKEDDTSGTPNGIPDSSWDKQSQVSGTVEKSSESGESGKEKLKENGWEKDVPVLKELKAAPIPAVNVWQQRREAQEAKAKASAALKSTTTAAAKPFNSKSSVPSENRAEGSKGGPRKKAGGSEVAADAAIAKKKSSESGKSKEEETLPPVGDASSWPTPQLAQGEEFRKAQEKSDKTEKSEKEKAPTAGSRGKEKWMPVPYVPTAVFNTPLPPAARRGGRPSRGGREGGMRSGAHPSAAISSSDRSVPASASAAGGSKQTGSSDRGRSGTRVDSDQSGTTQPARTGSVNAPLSPDEKKAPHDSRPDRASSDSKSVKAPEEPRGTTGGETQTNHPAAETGPRQRQNSKSFGRSHDYSNVTSQRGTEHTGRHAGVQGDSHAGTRFSSGHERRFDNGPRSAEFYKEPPFHPRDRELSNQREREYPRERNDFHRDREYGRERGESRPERGRGGYRGRGGHSNYSGAHNSQYHSPPVGQSQFQSTKPFSLSERHRSHHQASQNGGQQHGSNRGLNMRSPSLPSSGVYGPTPYPIQTDLNAMYGYPVLHQGPMTAIPYHPYMEHSLMSMISMQLEYYFSVDNLCKDLFLRKHMDSQGFVLLSFIAGFKRIKSLTEDMDFLRLVCRQLKSVEYRPGEDGNDRLRKREKWEQWILAMENRDPSAQNEGPPPLSLSTPAHDGNSDGLNSSHLETTALYGNGSLHEISGNAIPSHYSLSNGATSDTRVHQSVLSSAAPEFSPAYVPVTGQNENANQRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0T8</accession>
    <name>A0A179U0T8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CMGC/SRPK protein kinase, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_03810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00899">
        <property type="protein sequence ID" value="OAT00899"/>
        <property type="gene ID" value="BDCG_03810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03810"/>
    <dbReference type="OMA" id="KIPRADC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="304" mass="34836" checksum="E103BCB6553FB021" modified="2016-09-07" version="1">MNQMKTLSLRFRFHLTRPFHYSGSPRTSSTFARPRLAGEEPDFYGEGGFHRVALGDTFDAGRYHILRKLGYGQYSTVWLARDSKHQRYVALKILRADCYGGPERGILSKITDISARSKHEGRHHILPFLHQFKHIGPNGVHVCFVLEVLGHHLYFQCSKYKDGRLPVRAIKRIARQLLLGLDFLHTECGVIHTDMHPKNILLELEDPHTAISRHLSEVPPRTDTQSGEVLPLREVMKIPPISEIKEPYIRIIDFGVATYRHKHHSQKIQPPALRAPEVTIGAPWDTGVDIWSLGCLVSKYLFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0U5</accession>
    <name>A0A179U0U5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS multidrug transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01400">
        <property type="protein sequence ID" value="OAT01400"/>
        <property type="gene ID" value="BDCG_05134"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05134"/>
    <dbReference type="OMA" id="FIIWTIP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="81"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="483" mass="54405" checksum="06C62479D9FB0F19" modified="2016-09-07" version="1">MSANSRGSACYSKRNSTHANTQYQHNGRTQMLGEEDTWEVLVLPTTPSPENGEDEDLEVRWDGPDDPADPRNFSLILRWSMVTIITLCSLCTIFTSALYTMTYDQITVEFNCSTLVATLGLSLFILGLGVGPLFLAPLSEFYGRRPVYLVAMVLFILWLIPCAAAQNIQTMLISRFFSGFSSSAFMSVAGGSIGDLFSQDDLQRPMMVYTAIPFMGPIIGPLVGGFINQYTSWRWSFYVVIIWSASLLICMVFLMPETYHPVLLRHKAQRLRRETGRAYYAWIEKTDKSIATEVMWSFARPLQLLFLEPMITCLCVYTSVALGILYLFLGAFYAVFTHNYDFELYQVGLSFLGLLFGTITSFATHPLWNWNYRRLVRQREANGGEPGESEPEYRLPPAIASSILLPLGMFWFGWTTYKSIHWIVPIIGSGFFSAGVVLSYNGILTFLVHAYPLYSASAMGANLILRSIFAAAFPIFGVRCKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0V4</accession>
    <name>A0A179U0V4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BCAS2 family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_03033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00541">
        <property type="protein sequence ID" value="OAT00541"/>
        <property type="gene ID" value="BDCG_03033"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03033"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="PTHR13296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT00541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="186" mass="21005" checksum="5C3B4B82404FA09A" modified="2016-09-07" version="1">MAPNHQTVLHPSIPALPQSQFSSLMQKELDRKEANLPLTGGIDLSRYEAPEAPEDTLASGKEPAEILHCWQQTLRKAYTASSHLSTRQENLALLEAHGKNAWLIGNSQLEDILRRIEKELQETKEATDAVHKERKMRQETARGELVGLEDAWKRGVSGIIDVELAAEKLRQDILERRRQLSGVQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0W2</accession>
    <name>A0A179U0W2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dual-specificity kinase</fullName>
            <ecNumber evidence="5">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_05982</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="5"/>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01766">
        <property type="protein sequence ID" value="OAT01766"/>
        <property type="gene ID" value="BDCG_05982"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05982"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="720"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1342"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="432"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="720"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="831"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1379"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1065"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAT01766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1450" mass="159322" checksum="FAAB28B321DC8BEB" modified="2016-09-07" version="1">MPLQKSMPQRPSRSKSSSNPPPHNDDSGSGVEVSPSRRVQKNSSSGSITTDSSNSSSLPFRNSTEQRVAVAPARRRLSIREQNTAVGPRNGDPVKRSTFTNYSNPQMYSESPSIQSSTFHGHAENSNSPLSFSSATASGSLKDEGQTPPDNSDFLTPISFDDFHNSIMSKEPNLSHFPLSLGSSYDSKPPAPRSTPRWQSQQQPQNGSHVRTVQLARRESNASRSTMGSVTAVNGNTQTQATTASRPRRLSHAPPPTSTVTTSRPPRKSIGPGNLISDNGDRPPRRRPSLSARKNMADANRPGQASFAPQNFGAGGPSEPSTFLNTPRYQKSKSLQPPSRTARDSKDSLIIPSTGSVPLRSSSNNAVRTPAKSGLNRTTTPSSSKRISVMPPHATGLGARTISPTDARRMKRMSLMPQPPPMPHTPPTQQEIVLPRPRSSAQSPSMIPRKSVTPSSSRTTPDPHRKSYSSGISLSSNTSYNSARNSNGSLQPRLSQNISTSRLPTPKPRTENTSNNDEEEVPPVPAIPKAYESPKTEGELQVPNTRKSSLPFETGLHKDNSRPDSNAIETPSKGPVRDDFHVTRPIIHRMDTKPRPVSNIGRKNLQPLKLPPLNLLPLSIPMTTKIESLRDKNTEDTTLRISRTPPPRQTLAKTPTTPMTASKASFFSHNLHDHEPLPSTQPRSTSSHHALLTDPIRFRAQNSSSALEPLDILSDHRSVSPYVSSSLPKTSGEFSHVPPQLPSEYSRNNASRLTGPRPQTQFATFSPRLEGSSLGPPTTIDTESESSAPPFTRRNPSSDHQRTKSYHTIKEPGSDSAKYGSMPPPKLPASATWNNLLTAGQNPGSKPTYLHSRRKASMSSVTNGLVQRTQSISSEQSLALNPSPSTDAGDTDSPANPSASSLLSPVHKLLSSSKPTTPKLRPQDQNFDRDDLSAEEEMRKLGSKRKDFETAAKELEELRRRASPKERVGPAQALKMASLNIFEKGEIIDFKDIYFCGTHKAKKHVGDLNAQAANFGYDDERGDYNIVIGDHLAYRYEIVDILGKGSFGQVVRCVDHKTGVLVAVKIIRNKKRFHQQALVEVNILQKLKEWDPHRRHSVVNFTQSFYFRGHLCISTELLGMNLYEFIKAHDFRGFSLKLIRRFTKQLLSTLVLLHKNKVIHCDLKPENVLLAHPMHSEIKVIDFGSSCFENEKVYTYIQSRFYRSPEVILGMSYGMPIDMWSVGCILAELFTGYPIFPGENEQEQLACIMEVFGPPEKHLIEKSTRRKLFFDSLGKPRLTVSSKGRRRRPSSKDLRQALKCDDDAFPDFIARCLRWDPARRLTPNDALNHEFITGIKSIPRSRGYLAPINSPGKRMASGPASSTIRPLPDPPSHSTKSAGRPRDMPSQSPIKNTGPKRNSATTNVSAANSATKRTSNGNLMTGSALPRVTRATSGKADLATAAAATSLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0W5</accession>
    <name>A0A179U0W5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
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            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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    </feature>
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        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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            <end position="154"/>
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            <end position="17"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <end position="56"/>
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        <source>
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        </source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
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    </evidence>
    <sequence length="820" mass="90850" checksum="C175D48778DFD265" modified="2016-09-07" version="1">MDQDGGMHRRREHDGGPISEVAGNGASTSHSSPLLQPPDARKASRTSTANTASYKAEERNLHNDSKPPLVKSHTAIPTTKPPVAAAASPSLSQPQFKLSSTSNQESQCQALIDPLSQHILQRTNTDRSNPPRLRTQGKSDTEPGGSEFQWALTQEDSSSGILREASLYQKNSKEKKKGVSFLSRIIGSKKKTSAEWKDDVSETGEIRATGMDAEVFAQPIGFIPRYPPPPKYIKVRSHYKKDKDFNRLFIAQELCGTCSSTKNKSLDGKDSSTGSEEIPATGKAIWALEFSEDGKFLAAAGQDKKVRVWAVIATREDRQAHEIEEEAQNDKPFIRLRAPVFKFQPVREYESHTASIVDLTWSKNNFLLSTSMDKTVRLWHVTRNECLCCFKHNDFVTSVQFHPQDDRFFLAGSLDSKLRLWSIPDKSVAFVTTLPDMITSVAFTPDGKYSIAGCRNGLCLIYDTDGLKIHSQIHVRSARGLNAKGSKITGIDTIVQPPNNPNGLVKLLITSNDSRIRLYNFRDRTLEVKFRGNENHSSQIRATFSSDGKYVICGSEDRKVYIWPIASPERDPEKRAVEIFEAHPSVVTTAIFAPNKTRQLLGATGDLLYDLCNPPPITLVSQAPSVASKPTTDAGGSREGSLAPTPRSSTFPLTRKPEEFQPPSTKFSHPCGNIIIAADANGTIKAFRQDCGYHKLRSDVWDTGFSRRILGRNNSFSTRHSIASSLGKDSIHKTPSERILSWRNTVMGAENSSFDNLRSSLSMRTRSISPRKSSTKQKEKNKDKPQRGRGQGQGHNPSVVFNPAEEPSIHTARTTYQQQA</sequence>
</entry>
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    <accession>A0A179U0W7</accession>
    <name>A0A179U0W7_AJEDR</name>
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        </submittedName>
    </protein>
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            <taxon>Fungi</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
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        <property type="entry name" value="Sec2_N"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="180"/>
            <end position="266"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAT01744.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U151</accession>
    <name>A0A179U151_AJEDR</name>
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        <submittedName>
            <fullName evidence="2">TdiB protein, variant 2</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
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                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAT01834"/>
        <property type="gene ID" value="BDCG_06154"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06154"/>
    <dbReference type="eggNOG" id="ENOG502SIKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEPSWNF"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="Aro_prenylTrfase_DMATS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="PTHR40627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="423" mass="47021" checksum="5BD7CC874BFCE696" modified="2016-09-07" version="1">MAGQAVSAIPEAASAFQQAAKVTATRFWSHYLRSIMAPLFKSVGAYTESEQESHLQFMDEHIATNLGPLPNDPHSPYVVPAAIVGAPFDPSINLTSFGSGKVRFDYTVVEPIERPKEDPFSENLAREMLHKLASVVGADTRWMDSLMSSLYLSPAETDALLASMPPQLLCPPACIGVDFDGPKRTLKAYIPGVRKALATGQSSAELVLEAIRDLKPLGSELAPAADLLAEYLANCKHDIILLLAGIDCIDPTRHKNARVKCYLHSKANSFSVVRDVMTLGGRLNDEASLKRVDILRSIWPLLLNEPEDTKQIDDDWSKPERIKEKLYTGIRYTVEMTPGKKIPETKLYMPVFQYTETTDITEKNFENTLKKLNIEWGHNGKYGEVMEAVFGKEKDYTQIFSSFSYTAGKGAYTTSYFAKPIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U160</accession>
    <name>A0A179U160_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mannosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BDCG_03321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphosphodolichol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:12629"/>
            <dbReference type="Rhea" id="RHEA-COMP:12630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Endoplasmic reticulum membrane</location>
            <topology evidence="3 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00661">
        <property type="protein sequence ID" value="OAT00661"/>
        <property type="gene ID" value="BDCG_03321"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03321"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039485">
        <property type="entry name" value="ALG12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="PTHR22760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="PTHR22760:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAT00661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="497" mass="56042" checksum="198893CB6FEAC834" modified="2016-09-07" version="1">MRGVVGCFNALVLISYARGVRRAFGKNVAVWYILFQASQFHVMYYASRTLPNMFAFGITTFAFRYLLPEPASTVQDVQSRKRCRLSLYLLTITGIIFRSEIALLLATTTIHLWAKNRISFRSEILPAAISGLTIGLLTTITTDSIFWQKFPLWPELAAFKYNVVSGHASAWGTSPWHFYLTNALPRLFLNPITYALCIPLSILQPATRRTATSLLLPAISYIFLYSLQPHKEWRFILYTIPPITTAAALGASYIWTHRTKTHILYPLLATLLCLSTLTTFVLSTFLLLPISAANYPGAYALKALHNNHPYNNIKNNSTRLADQQTISVHLDNLACQTGVTRFLQKPPPKSPLIILPGSPDGRYPELRSGEQRWVYDKTSAGSVIEMEKARVERFWASFDYLLVEVGDGDGDGESDRDRPGRWEVVDEITGFGGVRILRPGEGEVSGGFEEEILGKVFGGKAVDGWRWVKGFGRKYVTRGWWVEVRIVPKIRVLRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U172</accession>
    <name>A0A179U172_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-C3H1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01048">
        <property type="protein sequence ID" value="OAT01048"/>
        <property type="gene ID" value="BDCG_04165"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04165"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039278">
        <property type="entry name" value="Red1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563">
        <property type="entry name" value="PTHR21563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-C3H1" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1315" mass="142914" checksum="2F47F5B331CC5132" modified="2016-09-07" version="1">MSSNYPPTPSFGGHYNPSQQWPRDPPSSALGEGSDAYHPPPQSYSTNNPSFKSSTQIPGFSGNNNLPIPFAPPFPFVPPFPPSVGFPQQAIASQPQQNGLAENLPPTLTGATIKENDTAATAEGSDPMESPESTNFGDREEGELSNGEIGAEEPESYGYKDHQPKEDIAGPYLQPHRPNEKPKRYSDVGAQGQPSFSHSSSTRQQPPEGPRNSNKLGKHQFPQPNKTSAGFSGQDMRPADLDTGTSAVHGESAQDKLGSRGHHTVPMEDARSPRESLPVSSVQSPASCDKIDITTNGSRTYPLYGKSPAQLRVQAQGALLGLAPHNIKFDELVNEGIDPVILKRLYDEIGLKITSTRNKQHATTNQSKEEKPMSAAKPLVVPDSDAEAAMTPVSRSAPDALVKGPNSEVVPEAPRIPNHQPTQGISNTFTTDSSRPMERKDIIARMLANKAAKPPSTTESSKSEDPKKSIPLQKSPSVPANDIPSTARMPTSQSPPQVTSETRAKEKNKAQTELARQRMEQLKKQGIGRSQTRSAVEAPAVAQRLPASNSLTLSSQNSTSPSQSSQPLPSLSHPLPSRPPAPEPPSNARIPGLFMTSSEPTKTQEVSINSNNSIPSAEPSSIKIRAPRKRPRASDFTDEPSPALQKTQFAQEKSVSSTQHKVIIDISEDEFMYGSDNDTTEPKGPGAESPFVGSGRTSTSNQLLTRDLPPLSDFPSRNYSHRSTPAVSTPQPRNRGKGPDDLNAELQAMRQRIAEYEQRKKAKQSASRVESPGALAHSATTSADENSSAAPEAQCKPTIETELAVPPSSQPENSQAHSTSPEKVVNSGIQATLNSDGALRSQSVLPQGSLDPTHIESIRKKFMRKREIESGLPVLDAELQRSEARLRQFREEEQRLLAEIEKGKAGKRLLIEELESLGIETAGQSIEELQATKDRLEEADEDEDMCDDQAQQPTSKETTAEIALNNQESALSGVVQDRGSTSSIQPSAREQMAAPRFETVPKTSQEAIDMRMSPPKETSVLSQADIADDGTTCSSSAMDESMGSTQDMLDLEEETQDPEALEERAPSRSESVAKSKITDMGERSSQASVSPEPLHTGLENKPAPPVVKPDNSGASMSYQGSSSGSDGYEPPEPDPAPEQPGLVQTSPCLVLPDEVEHGAVTDLGPDSPKAKEDAERAHRYFTPYRSPLRLFKAYRYHPRFTEDVSGGYRSLTYSHNIDPHNYVCPYEAAGGFCNDHSCEYQHFRHMTLSDDRILVEMSSLREGKTPEERDEYVAGLKQTISDMRRDKVKDLNTIATEVTGYRRRFLRDPSRVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U174</accession>
    <name>A0A179U174_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01049">
        <property type="protein sequence ID" value="OAT01049"/>
        <property type="gene ID" value="BDCG_04165"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04165"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1158" mass="124611" checksum="01EF3B96E0A311DC" modified="2016-09-07" version="1">MSSNYPPTPSFGGHYNPSQQWPRDPPSSALGEGSDAYHPPPQSYSTNNPSFKSSTQIPGFSGNNNLPIPFAPPFPFVPPFPPSVGFPQQAIASQPQQNGLAENLPPTLTGATIKENDTAATAEGSDPMESPESTNFGDREEGELSNGEIGAEEPESYGYKDHQPKEDIAGPYLQPHRPNEKPKRYSDVGAQGQPSFSHSSSTRQQPPEGPRNSNKLGKHQFPQPNKTSAGFSGQDMRPADLDTGTSAVHGESAQDKLGSRGHHTVPMEDARSPRESLPVSSVQSPASCDKIDITTNGSRTYPLYGKSPAQLRVQAQGALLGLAPHNIKFDELVNEGIDPVILKRLYDEIGLKITSTRNKQHATTNQSKEEKPMSAAKPLVVPDSDAEAAMTPVSRSAPDALVKGPNSEVVPEAPRIPNHQPTQGISNTFTTDSSRPMERKDIIARMLANKAAKPPSTTESSKSEDPKKSIPLQKSPSVPANDIPSTARMPTSQSPPQVTSETRAKEKNKAQTELARQRMEQLKKQGIGRSQTRSAVEAPAVAQRLPASNSLTLSSQNSTSPSQSSQPLPSLSHPLPSRPPAPEPPSNARIPGLFMTSSEPTKTQEVSINSNNSIPSAEPSSIKIRAPRKRPRASDFTDEPSPALQKTQFAQEKSVSSTQHKVIIDISEDEFMYGSDNDTTEPKGPGAESPFVGSGRTSTSNQLLTRDLPPLSDFPSRNYSHRSTPAVSTPQPRNRGKGPDDLNAELQAMRQRIAEYEQRKKAKQSASRVESPGALAHSATTSADENSSAAPEAQCKPTIETELAVPPSSQPENSQAHSTSPEKVVNSGIQATLNSDGALRSQSVLPQGSLDPTHIESIRKKFMRKREIESGLPVLDAELQRSEARLRQFREEEQRLLAEIEKGKAGKRLLIEELESLGIETAGQSIEELQATKDRLEEADEDEDMCDDQAQQPTSKETTAEIALNNQESALSGVVQDRGSTSSIQPSAREQMAAPRFETVPKTSQEAIDMRMSPPKETSVLSQADIADDGTTCSSSAMDESMGSTQDMLDLEEETQDPEALEERAPSRSESVAKSKITDMGERSSQASVSPEPLHTGLENKPAPPVVKPDNSGASMSYQGSSSGSDGYEPPEPDPAPEQPGLVQTSPCLVLPDEVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U177</accession>
    <name>A0A179U177_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01463">
        <property type="protein sequence ID" value="OAT01463"/>
        <property type="gene ID" value="BDCG_05259"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01464">
        <property type="protein sequence ID" value="OAT01464"/>
        <property type="gene ID" value="BDCG_05259"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05259"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="390" mass="43083" checksum="7AF7ACED35F986B5" modified="2016-09-07" version="1">MDGDSHQRKTYGPSGYRTGSGIGQHPIRHLSGSSSDRFRHQQQPEPARGPDTHEVIPQDRTSSLSAYGAYVYTEPPSCNTPSLQGGTLQGGGLQYESNFSSTSPRNQQPDQQQQRLSQYDGDMVYGITPQVQPQAPYEGVSQYQPRQSAAIEVLATQFGVPQYFQPAGPAVAGVSDQYLTASQVQSTQYSQPASPTRASTTSALPEIMADLHASAATEGLEHADFPRESPSGFDDAYNQYQRALRQTFENTRSGRLLDASQSLLEISEWLLGNATELELRPDRIKLWNEFNTCWLAVCQKQKDMTQEVLETRSGATPQNLLTEDILNKMGRELVRLCDRMEEHGLVDYQMGVWEEEILSVLGQCLDLLEGNENNPTIGSSAKTSTSTVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U179</accession>
    <name>A0A179U179_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_06244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01876">
        <property type="protein sequence ID" value="OAT01876"/>
        <property type="gene ID" value="BDCG_06244"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06244"/>
    <dbReference type="OMA" id="WNPHGAK"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034771">
        <property type="entry name" value="CPSF6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="PTHR23204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204:SF7">
        <property type="entry name" value="PTHR23204:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT01876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="417" mass="43756" checksum="90296C286CF8FA2A" modified="2016-09-07" version="1">MANTEDDNFDIDIYGDGGGYNGNEQEGDFKGEETDIILDASEQHQNGEVNNEGTGEKYSNGNGQAENGSHKIFKTGESSTATPQPAKPPQAQSQPPAPPQQGVKRKESHDDRTADPDATTALFVSDLYWWTTDDDIRGWVNQAGVENELKDVTFSEHKVNGKSKGQAFVEFKSPQAATAAKHKIESFNTQQSSRKHTVTYTHPHTNPFRTLPKDNPMRGKDDRQARSGSTGSFGSPSTQSSSFGMSSGGAYRGGRGGGYNRGGMTGGFNANRSFSQPMGAGNFQGGAMGGGFQTAPVGGMQPYGGFNNRGGMMGNMRGGPGGMRGGRGGMGSAPNPMMPVGGVANVGGMGAMGMGGMPMGGMPNQMGGMMGGMAGNMGMQGGFQNQNPHFNPAFFGQPHGGNDGAWNPHGVKRTRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U188</accession>
    <name>A0A179U188_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDCG_06279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01885">
        <property type="protein sequence ID" value="OAT01885"/>
        <property type="gene ID" value="BDCG_06279"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06279"/>
    <dbReference type="eggNOG" id="ENOG502SE9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="10">
        <location>
            <begin position="1147"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAT01885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1199" mass="134381" checksum="E6459C737417D068" modified="2016-09-07" version="1">MASPVPLNQFSLFHAIGNTPAVCLTQDIPGDDPARLLLLGCGDARNILFTSFMNSSSKPRPLDYTCCDIQPAVIARNVLLLTLVVDTNEGADTSMLWNIYYHLFIDDKSHNLLESQVKKLHRFSSSLKYWHKSEYGRFLRFCDSKTLALVRDIWHSYISVRDKADYLASFRKAIQACLDVKVATAGSGIDLGGARAAAPNAIQALKDLPGLHSRYWKNGSTSNDPKALNVHPNPTLAPLENDNALLHSGTDPLLGFHLVTAYTPVDAGSHFYRKEVAFAHAQNAVESARLQFNIWCQSLKRDHKSVTVRFFAGDALAFCHTLQHLDTTRETSAKWFRTSYGFDTVSLDGEDYALEDGVAPLAFDVIDTSNLIDFLGGINVFIAAGPLLYEKESSTIYAESFAKYVPEVDVLLNDLFAGHFPTVSILLGVFPVQYWTNSSAVANAEEQLMHDFRKCSMGDGVNTRNVYNRTLWKYQWPYWSHSPGSSCSSLIKFDPDSLAVVLFGIYMNMFMNEDVKFVLAHPSCEMIRYHRGSFVRFLAFVKGRVMVDWNKAISALITLIEADKALGVGQNFLHELYTQLHILDVYSDPLFTKEFKYDRSSHDFRAWKKMPYLVSITVKVPRAKLSVFTKTRCGKLAKPYINGFVQSKQMGLGQHSLFAVVQLGFGQAICSGPRNSDHFAVTIAKDHSGWKGKSPLIISFVVPSALLLAQPESTTVGMSLYHTPGISSMFEDALGTELVVFSSDLGNQSSVYISKHRPNHAGMPCPPQLWSNRVYPAKMHASSYHVTLTADIDKKKRIIDRFTARIDFLSKEAKAILTRQNKIVVSQPSPCSLRVPVEGQASEIVITFPAPVLKPNKKNTIRVARKSSYVEIIAHRAEKPDRQGYSDYMFPVFLSGGEPLAWNIPYLNPNRLPILDTNRMEDFGWLITHVSTMFSGKECEVRSNLDNTRPKPDQDSRLCFKDTLFAMHMSFARVKGEKCKVFGISCGDIGLHILFFRSSVRMDISNHTLALDVAIVPLRLDMEKPIRDFIAKLDMDELITMLVKEDELRLWKKLLPAFVERCREWKHKPTCEYKAKSRIPLSVELHQPVLCSCGNGIFPPNFVGDFPKWETVSKHAIRGLIPLLFTLPYLDTKDALGKEKKAGQNQCEACGAGKSVHGRALLSCSQCHLVRYCSSKCQRIHWKAHRKTCLGKGTGGPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1V3</accession>
    <name>A0A179U1V3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00352">
        <property type="protein sequence ID" value="OAT00352"/>
        <property type="gene ID" value="BDCG_02533"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02533"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="259" mass="27827" checksum="3FB8060D47625AF0" modified="2016-09-07" version="1">MVQIQRLALHFKTQGIAFNTVFSSDLLRARTTAEGICGLAGGEGRDGDSPQLQPIVLPVLRERDFGALEGKSWLTARDGAANSVSETAGEPESHASVASRADSFLSNHLLPVLLDAGHPAQAVAVVSHGILLAALWEALSRLFLSSHVVLAPGVKVTKRISTWSNTGYLELDVGWIETGLITPAPANESGQSHDTMDGSNRAKAKNDAQNPPLHGRTLTILTINGREHLRNLRRTPGVGSSKHDATQQRIDNFFQKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1V5</accession>
    <name>A0A179U1V5_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C6 finger domain transcription factor nscR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Neosartiricin B biosynthesis protein R</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_04784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor that specifically regulates the neosartoricin B biosynthesis gene cluster (PubMed:23758576).</text>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01279">
        <property type="protein sequence ID" value="OAT01279"/>
        <property type="gene ID" value="BDCG_04784"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04784"/>
    <dbReference type="eggNOG" id="ENOG502RXDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="Transcription_factor_dom_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="SSF57701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="614"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAT01279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="724" mass="80471" checksum="45F8AB2C37C8CC13" modified="2016-09-07" version="1">MSEKPAKPGLTRKSAFSCEACRKRKVKCNGANPSCSRCAARGETCIYSLTPTLSYTKTLEARVAELETALANLQGGTGNIDGGLGQEISQQHQQQQMHVDEPRGNLLRTGVSHGVDNIEHIPSDLTRGIDRLKIGDDGRISLYGPTSLFQLPSSLAPEEANPLLPAAAELDSRKERLINNAWRERAFEQLATIPDPFQYLLDSHWCWIHPLYNFVYRPAFTRDMKMNGPYFSEILLNAILSHSMRWCKDELKITKYIDASSGGTQFFDQACSGLFNTLKAGNGQIPIVQSLLLLSAQECGRGNTTQAWLYSGMAFRLVEDLGITIDSRKYSGSVQFSDEDIEVRNRLFWSCYFWDKLVSLYFGRSPIIQDTPVSPPRILLDDTAEIEIWTPHGIVFPEGTHYPPTQAYATSCFMKMCSLTEILNQIIIHVYDPIRKSTEAEFQTCVGQQSRNLEEWWDELPVFLKLIVDYLPPYSPPSHIVTLNCVYHTTNILLHRPTLCSRPFRGSAQVTSNAKPLVKCISSATSIITLFDLYRRTFGDGHVVLSLAYSIYTAASIFLLEMQALRYASPSTLDKLRFCIAALTRVTASNPVIKTALKLIEQELEKLGIDIRDPSADAKKSHNNSTNSPSSSSPTSQSPYPYAVPSHGAFSFAPPPLTTQSGVGEDPFRILADADPSLVIPDSLKQEGVYDIAPELFEAFSYVEPLSANMGGEFDPGWEDGEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1V7</accession>
    <name>A0A179U1V7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02105">
        <property type="protein sequence ID" value="OAT02105"/>
        <property type="gene ID" value="BDCG_06789"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06789"/>
    <dbReference type="OMA" id="PALIICK"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="PTHR37315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="378" mass="41235" checksum="2A94C1D589EFE3B5" modified="2016-09-07" version="1">MGRTVDQEVHAAFVEFRAKEDDKCLSVQCIYCQQIRAKNTSRQKQHLLECPALRGHNPPHPQSAPTNGVGPVNGYGAAPNGPAGGPGAGALQTPMQNLSSRPSLPSQAAPPPSASSAAPQAQQRAHSTPKSSKQPRQSTSSLPAPPLDDVHAAFVEFRAKEEDKCLSVQCIYCQQVRAKNTSRQRQHLLECPPYLNVMKDSIPANNLQHSFPEGDIARSLQLPIPTLELDFRMSLKLNPTVTVGQGLWGQRDWVTFVGGQWAGRWGKGIVLPGGQDSQVVVKELSTHIKANYLLQTADEPPAFIVAKTTGWMTGAKDVLEKLADPSMADSVNPTTYKYRINISLETGDERYAFVNTVMWVGSGCRRSSEVIFDAFRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1V9</accession>
    <name>A0A179U1V9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="4 10">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_06790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="4 10"/>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02106">
        <property type="protein sequence ID" value="OAT02106"/>
        <property type="gene ID" value="BDCG_06790"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06790"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016300">
        <property type="term" value="F:tRNA (uracil) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="PTHR21210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAT02106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="580" mass="64701" checksum="6E70718B80746F1D" modified="2016-09-07" version="1">MPSESFSGFRLNRTVVRRFVPRKQIDRPIEQTCHFYEGTCNVDISGVACMERQRCLVVYTPHVRSEDKIPYYHPQVRALALLYDIDRSTKSESEDSGTLSIHFSLFIPGLPQFITYRLQRTLLALVSTHVRLSRKSLAAAGPPRSKTVAPKDNLIPQHVVQNTYARLKEEHAAHLINSWVETTEPSKHVFEDISIAAFLIELWRGMYSLPNSKQTDNTNESKDGLPPFPGFVDIACGNGVLTYILLTEGYNGWGFDARRRRSWSIFPTSIQDRLKQIICIPKPFKDILNHMEGETSILKRAQESPTDVHEGVFDKDTFIISNHADELTVWTPLLGTLSNPERPLPFLAIPCCSHSISGMRYRYPAPKPPSTKDNDLIKTYMPAEKNHHNNNGHIVINGITEPVKQHQKSEVAVESIPPAPVAAAAAAEEEEQHQNPQSSTGDLKSLRAVKLDERTKPDCQSSMYASLTAKVMQVAREVGYGSDIDKTLLRIPSTRNVGIVGGVKGVMLKNGGAKEMEEQSLCLCLNGGDDVMKRVNNVVERECSRDGGLEVAAKLWVERSLGLQEPQGRGRLKGGDGHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1X0</accession>
    <name>A0A179U1X0_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C6 finger domain transcription factor nscR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Neosartiricin B biosynthesis protein R</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_06812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor that specifically regulates the neosartoricin B biosynthesis gene cluster (PubMed:23758576).</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02116">
        <property type="protein sequence ID" value="OAT02116"/>
        <property type="gene ID" value="BDCG_06812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06812"/>
    <dbReference type="eggNOG" id="ENOG502SHFD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="Transcription_factor_dom_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fungal_trans" evidence="8">
        <location>
            <begin position="226"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT02116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="585" mass="67116" checksum="919C18C78A772B84" modified="2016-09-07" version="1">MKLRCDGACPCGACLKRNIPCTRQSSRPYDDSETRTDSTKSDDFDQTSERGSVKFLLNGGTDSFTEGFHLPSRHDRAQVLSWPEHNHNHVGNMSQAMSTREPVNLPDNAHTHHPVSGIESQPVDVAFYNDGFLQFFNGGYNTGPRFQPDETPTSFAHPPATPIQGLPLTSSAEPYFQPESPYSTNLIQSILSKSWVLGLDEISSMELAHELRFLLMTQRIQKFVALYFQSWHNNCPMIHQPSFNPETTAPTLLAAVVLMGATYSENASERLAAKKMSDVIEMFIFSTEVYSQEFEIAQSYKVAHDRVDIKTDWRSFENFQAGYLMFLIQYWGGSRAARNRVIEVRFGEVVRVARQMQLTKCRHGLEDQMSEYLWLQKECRIRTMILVSMIDSAMPFFQNYPSRLTNIEIQCDLPCHESQFAARHPFLEPDFRLSREMTVYQAFQNLFVENGPVRPLFVHCGTNKLHLGIMDMFLLIHQIYAHIHMIINLAMPQFGNRNINKTDCATVSGIKVALEHWRSLWISLRTELPSTEWERVGFFKGAYNYWLVAQLLISKNASVDILMRMEINCEDKLSQLKVLLPDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1X2</accession>
    <name>A0A179U1X2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_05876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01713">
        <property type="protein sequence ID" value="OAT01713"/>
        <property type="gene ID" value="BDCG_05876"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05876"/>
    <dbReference type="OMA" id="HVQNADW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT01713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="733" mass="84686" checksum="B6894BCEFC40D063" modified="2016-09-07" version="1">MRKVAAQEIYDLEHLRKVYTNPERNSEAVLRVFHVQNAEWATNFLLRKFNIDNRDDLVGTDFGRYVRHKRPERRGGKPFLSGKTWKVQYDPWRGISKTSFGVDYFKQYRCPDPMNRVPRGPHEQDDSLKMMELNCFDQNDNPKYGYDVYVQRVSCYIQHKQSAIGVPTNPDIKNPYIIDPPKTDSARQRRKNEYIPRLDTLDNGNAILIFDNSHTNCIEDTLIAARRFWESRWRRLPFFLAFESRDLVATDEQLAYQCSKIILEDIFKALVLEWDTFLDLAMDHVSILEDKVYEQPADETRAPELWLNSNIWLKVEKLLFIHIDVVKEMRPRLGELDDELNPDDTWLDNIPGDYDRLSTLVEEDLVKPTKTLISLLYQSVSIRDSRHSIQLGVSMWRLSWITFIFLPLTFIVGFFGMNVDAFADNPSIKWYFISCVPFMLCVLGAWYVVKHVIARQRQTPYQRGIYENFFHDMATENPSLWSRMGPRDYVRPKGYLARLKWYLIKRWSAPEKTIQARRESDDHGVDSLGAVSKLKRYLICRWTAQIAASQPVDPSSAGSLDAGQVSFDLEAGNPAEESHVVAEGLAEATEMLVIPATPVIEGAFSLEEPTSRLVAPAMYTTTNDEARLSRRWSRRHRHQSSDGSGDRSSGILVEEEDSRWLSERGKEGKRFMWRSSSSRDRNEAKKEKEEGKAELDQENKQAGSSSGAEGHEEVVTGSDAAEERSDEKTHPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1X8</accession>
    <name>A0A179U1X8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2 finger domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_06830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02126">
        <property type="protein sequence ID" value="OAT02126"/>
        <property type="gene ID" value="BDCG_06830"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06830"/>
    <dbReference type="OMA" id="PYAPKHQ"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="339" mass="36639" checksum="27FEEBC436452A3A" modified="2016-09-07" version="1">MINQPWPQSFPSRSGFSPPSSYAGRNNSNSPTTADTLTPSYDINQRAYFQTPIPGASTSSGPSPTTQQPQQAMAHVLMNAQATTATVPPTPPAQNNVDAYGQKLPSTPLYSGSHQSTPQQATFPPYQSSGSSAIHHSGTNGPSSRISPIQAQMQGEGQHQLTQYSSRPYPSYSLPAMSGPIMTNVHHPNSQLALMGSIQPNLLPAFNSGHAAAMSSVFSGHPNHIHGLMQHPPPDDRPYRCDQCTQSFRRNHDLKRHKRIHLAVKPYPCDHCAKSFSRKDALKRHILVKGCDKDKDSQSDKNSTTASSPVLTRTDNGTGNSASGRTHNIQGNHALKSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1X9</accession>
    <name>A0A179U1X9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2H2 finger domain-containing protein, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_06830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02125">
        <property type="protein sequence ID" value="OAT02125"/>
        <property type="gene ID" value="BDCG_06830"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06830"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="418" mass="44810" checksum="488BDCA985798A2B" modified="2016-09-07" version="1">MGTALDALNSHQSLTSRRPAANNLPGFELLHPQVSQSQKYSHPSSTNAQQPSRVGSLLTPPSNTSSDASSISAYVSHSSVSSSQTAPSYSQGYWPQSNSFGTGRNNSNSPTTADTLTPSYDINQRAYFQTPIPGASTSSGPSPTTQQPQQAMAHVLMNAQATTATVPPTPPAQNNVDAYGQKLPSTPLYSGSHQSTPQQATFPPYQSSGSSAIHHSGTNGPSSRISPIQAQMQGEGQHQLTQYSSRPYPSYSLPAMSGPIMTNVHHPNSQLALMGSIQPNLLPAFNSGHAAAMSSVFSGHPNHIHGLMQHPPPDDRPYRCDQCTQSFRRNHDLKRHKRIHLAVKPYPCDHCAKSFSRKDALKRHILVKGCDKDKDSQSDKNSTTASSPVLTRTDNGTGNSASGRTHNIQGNHALKSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1Y2</accession>
    <name>A0A179U1Y2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_02607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00382">
        <property type="protein sequence ID" value="OAT00382"/>
        <property type="gene ID" value="BDCG_02607"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02607"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="PTHR12497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="304" mass="34891" checksum="1AB5E3E6E9EFD1D2" modified="2016-09-07" version="1">MDDPLMWGTIPLLNKRAFNSFNRRWAFGSHDICYSNRAVSAFFTLGQVMPTHRILHSPYGGLFQPTMTQAIRLLSRGPFSPEPHMAPASRQHWSLQNVCVDPFSEVATAYTTTGEDSHIAPSAYACNSFSWIHIFPEGKVHQAPNKTMRYFKWGVSRLILEASECPDVVPMWIEGTDQVMHEDRGFPRFIPRVNKNISITFGDPADLEEQFGDLRRRWRRIKAKAEEGQKDLSLGVLNDELKYGKEAVELRIECTRRIRELVLAVRKSRGLPDEDPKESRVETWLREGPKVEGKMDDGSWIRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1Y6</accession>
    <name>A0A179U1Y6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01147">
        <property type="protein sequence ID" value="OAT01147"/>
        <property type="gene ID" value="BDCG_04431"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04431"/>
    <dbReference type="OMA" id="KLENCSC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1011" mass="115297" checksum="27F4EBF71B7A09F2" modified="2016-09-07" version="1">MAFGAGDLDMPQQEAYEPLQRFQQHQIQETYQTQRQPVQQHQLQGQQHLPHSQQHHPAQQHQLHNQQYLLQSQQHHPDQQYQPQIQHIHHQLQNPHQQQQQQQDQQIHQQYQHPLQQHNRRQLGDNQQQQQQQQLQLQFQHQDQPQPQQYQSQVQHHFQHQPQDQLLRQNHQQHQFQLQEEGLQRWSFPYQLGPPIPGSGVFPRVVDLPEEQLQPRDINIYSSQPPLHQYQEGHRTGHKKTASWPQRIGTQRPPLQSGKRERSRYTRVEHRGTRRNSNRTSESREIEQSQPPVTTGRPQSNLAQESYSNVDHPLGPNQTEAVGNYPIQGVGNQVGYLGQGASRTTTIGTPASRKSPGRTPNHTGSQSDGIDDHQTEDSRGPNCPVGVMQTGRLHQMSSPEMNPQRAQLGNDPPALQPHLATTGPLGSSGGSPSSVQEVERRTPWEWDAILANPNSIPHQRTTHANSEMRDSTGMSAEEHDALSNPPDPGQKSSRSSSGPVPPTIMAPITSTGEDPLLMLLRAAEMILGPLIPKGMSSNAKEAGGEKLTASQKVLPLPVHFSLPYAMRTRDHSNPNAVRQLTLPALTNPRRNIKALRLPPLAQAFRNVNECSEGSDAPPNDKLQVETFDSQTVRQSSFKCRGHQDRFVSAAERAQSDLLSLSNISQLFIMRKQELERGSGQTPCRGPGLEGVRYQYEAPFNIFQEILKRPELALLVTRHLRVQELLILYRTSKDFHHVVNTRFTTVIQAQACARAPEAAKIFPPRCYAKLCIPDPGLRPHPVAKRAALGETRKVPSFRWLLMVCFREMVCHEIVTILAEDGVPVPDRCTSTMKKIWLLMDIPDNARRIALVQNHEIFTDVDLFFATLFFVKLDMRFTDPITGSGKDDVMRLFARWKYQLRQDQRGLSIFGVPAHEVGIVQYQCWGRTGNRVPLQRPDELLLKESIRRGLDLQQRYTDMFLWGYINPRTMQDYLPVLHKRQMERMEGLEELLVPVEDRGKVEVGKVVSKRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U272</accession>
    <name>A0A179U272_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_05148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01409">
        <property type="protein sequence ID" value="OAT01409"/>
        <property type="gene ID" value="BDCG_05148"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05148"/>
    <dbReference type="OMA" id="HWQTRWF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="PTHR21229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="Lung_7-TM_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107146" evidence="9">
        <location>
            <begin position="20"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT01409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="532" mass="59692" checksum="3BA6A8CA8B624740" modified="2016-09-07" version="1">MKALLSCLYLGLLATGTLANEVRLKQDEANRQQCSGMYSRKAWGGDQDPFILVAFEKGELKNPEADHLVSLVIFEWKDEDLIGRYPVGDKEKKEPICDQENVAAKLCTKKQLGSFILAEDAAKVSKSPIISTAINLKDPKPINYPVAKTGFYCVSTYAFSGDDYQGVVTFQNSYGELPAPQIPKLPFYGALTIVYAVIGIFWAFLYVQNRHDILPVQNYITAIIVFLIVEQLMTWGFYDYQNRHGSNAVAKVLMIIVAVLNAGRNSFSFFLLLIVCMGYGVVKPSLGRTMVYVRFLAIGHFVFGVIYAVASLSITPDSAGPLVLLVILPLAGTLTAFYVWTLNSLSATMKDLIDRKQNVKALMYKKLWWCILGSIVVIFGFFFINSFVFASRRVADFVPDHWKSRWFVLDGWLNIVYLFDIAFIAYLWRPTVNNRRFAMSDEIAQEDDGFEIRSFGSSLDEEERVGTGGPDGPERELSPVPPKPVASSSNQNRHSLDGETIFAVGEDGDRWSDYESPRNSSERKGLMKKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U274</accession>
    <name>A0A179U274_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transducin family protein/WD-40 repeat family protein, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_06918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02174">
        <property type="protein sequence ID" value="OAT02174"/>
        <property type="gene ID" value="BDCG_06918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06918"/>
    <dbReference type="OMA" id="FTKGCQW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT02174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="375" mass="40382" checksum="64A757758469C6FF" modified="2016-09-07" version="1">MKQTNPPFTLTCAASTRNYAFSTPEKSLGKKNAVAGENRAISNYFKEASWTPDGTSIITNSADNTIRTFVLPADLIEQRKEPLELEPYHTIPSAEPIYAMAIYPFYGLQDASSTLLLSSVRDHPIRLTSALYPGFSASLICLFDVSRPGTDGPVSRLQTIPSKRKKIVGGGVGMKGIVSTMAINPSGDGILAAGTFTRYIGLYASNGCGDTIATFSVEGTAADSRVGGKGITQVLWSPCGRYLFVIERKSSGILVYDIRVTGQLVGWLEGRGGMTNQKLKADIVPGGERNATEIWAGGTDGALRMWLDPASVTGEGREPEWEKQVHDDPVTSAVFHHTGGVLATCSGQKKYPSFNDDETMDINASSDNRLKIWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U278</accession>
    <name>A0A179U278_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING finger domain-containing protein, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_02875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00462">
        <property type="protein sequence ID" value="OAT00462"/>
        <property type="gene ID" value="BDCG_02875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02875"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="385"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="545" mass="60287" checksum="6E5F481D8D744BD9" modified="2016-09-07" version="1">MAANAFDAVVHAIPSEGSSLTRPVPVDSSISFELSIGDKIQTLSTTNVRNGDAIRGLLYVPELDFEDPCRQATTPFILANVTRLSDIPGPRRSISLAPWVSSACTISFLAALSRNPPYAAVFYRPDESTTTPPLADHPTWDLGDRDMWKTTNRYPVYAIPGVYGASVMRALSEYSGSVADAPYAEDLLRRFQGSDVVRVSSKIAISKNSTGGLPSLWIFLLVVVAILICIALFSSIAMRCIQARQLRSLERRVAAGEVDLETLGIKRLNVPQDILDKMPLYICNGSGRIERLIPPTTEMTPESIDEPSKLPPDKGSFLQSISGWKWISRVSQAFYSRKSRSTTPPPPLSSAPDSGTSLPSPRSQTTPIDNNQQHHAEPTFAQTTCPICLDDYDWGETTVRELPCQHIFHPECIDNFLLQNSSLCPVCKKSVLPRGYCPEKITRVMVRQERLARRARPPQTIEIGNGGYDAAMPTSLGNGNQSPQNRATVSPPTGERFSRQRQEEMRMRAVAMLGYRPMIADEERAQDASRSKLRKLLQILFPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U287</accession>
    <name>A0A179U287_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TdiB protein, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01833">
        <property type="protein sequence ID" value="OAT01833"/>
        <property type="gene ID" value="BDCG_06154"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06154"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="Aro_prenylTrfase_DMATS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="PTHR40627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="459" mass="51158" checksum="1E80D72850E728AF" modified="2016-09-07" version="1">MGPRNRIIDIFCIASWVIIVCITNAEGCWRIAEITTSEESTVSAIPEAASAFQQAAKVTATRFWSHYLRSIMAPLFKSVGAYTESEQESHLQFMDEHIATNLGPLPNDPHSPYVVPAAIVGAPFDPSINLTSFGSGKVRFDYTVVEPIERPKEDPFSENLAREMLHKLASVVGADTRWMDSLMSSLYLSPAETDALLASMPPQLLCPPACIGVDFDGPKRTLKAYIPGVRKALATGQSSAELVLEAIRDLKPLGSELAPAADLLAEYLANCKHDIILLLAGIDCIDPTRHKNARVKCYLHSKANSFSVVRDVMTLGGRLNDEASLKRVDILRSIWPLLLNEPEDTKQIDDDWSKPERIKEKLYTGIRYTVEMTPGKKIPETKLYMPVFQYTETTDITEKNFENTLKKLNIEWGHNGKYGEVMEAVFGKEKDYTQIFSSFSYTAGKGAYTTSYFAKPIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U288</accession>
    <name>A0A179U288_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00472">
        <property type="protein sequence ID" value="OAT00472"/>
        <property type="gene ID" value="BDCG_02885"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02885"/>
    <dbReference type="OMA" id="HETHETE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="291" mass="33679" checksum="B0DD5E4D6AFC94A7" modified="2016-09-07" version="1">MASLLEWAKSTFRRAPSPHIRFPATGFETINASRILDEERFEDFKKGRYYPVNIGDVFSSKYQVIGKLGFGMTSTVWLARDLAGHQYVTLKVYTRNEASQEEFQVYKYLSQGNPSHPGYPHVRTALDIFTIPRPGGDHHCLVQKPMWESFRDLLYRHPSHRFTENLLRFGLIQVFLALDYLHTECKLVHTDIKADNILQEIEDKSILESFMNSEMENPSPRKFVRGVPVYASRRLELPKTFGRAVLSDFGSAVQGDERRNHDAQPNFFKSPEVMLKADWSYPIDIWNVGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U290</accession>
    <name>A0A179U290_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pumilio-family RNA binding repeat protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_07075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002621629.1"/>
    <dbReference type="EnsemblFungi" id="OAT02235">
        <property type="protein sequence ID" value="OAT02235"/>
        <property type="gene ID" value="BDCG_07075"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07075"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="453"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="519"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="555"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="747"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="825"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT02235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="856" mass="93569" checksum="8700ACD057C0BA17" modified="2016-09-07" version="1">MSFPVTGSPEAARKASMPFQGYGDIGSHGRVSSGSKCTTSGDGGPNPLVSSKLGNIQPMALNKDEAGPSNKKVEHAGSAPRTELQPSAMDQILAKLSPKGGVSVEQPSVNDEILAKLSEHQTMLEKQQQILIDKHMRSTSQNEGANTSTPHLSSGNSPNSGDNTSSKSSGDNVDKVDAIEMLRLKQELVAANSRIALQEQELAQTRVIKHTLDQALGPPSEADFGGREITEQTISSLQNAFNSSTRPFNQRQETWVTQDDAQSDISDALSAGAYNRARGIWNSGHPSFVMNAAGTKDTLYREHATLGSPTITPDPGRNWAGRLSHPGFGGHHPGYAPNQRVLSGPGSPTLGFDGRYTAEQAQYLQGPGNRHSSAKLNRGGSCFPPQNSPWGTFSTVAPGGPTTRAVSNQHAGPYPGIFPGPGQYQPRPIGTPLSPTAAEFTVNSAPDTWSTSSASGAVQTYVSPLEPLNYRRLLDKSVSCDWKYIVDKIVCSNDQQASIFLQQKLKVGTAEQKYEIIEAIVNQAYPLMVNRFGNFLVQRCFEHGTPEQVIAIANAVRGNTLSLSMDPFGCHVIQKAFDCVPEEHKAVMVHELLRRIPETVIHRYACHVWQKLFELRWSNEPPQIMTKVNEALRGMWHEVALGETGSLVVQNIFENCVEDEKRQAIEEVLAKIDLLSHGQFGNWCIQHICEHGAPHDKSRAIEHILLWATDYSMDQFASKVVEKCLKIGGSEFLDRYLTRVCTGRPDRPRMPLIDIAGDQYGNYLIQWILMNSAAHQREIVATHIRKHMVSLRGSKFGSRVAMLCCNPSHVTRPGPGAGVQVNRFSNPGGEDRFSGSQSSGRFNRGGQWSANYPPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U294</accession>
    <name>A0A179U294_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sep4b, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01870">
        <property type="protein sequence ID" value="OAT01870"/>
        <property type="gene ID" value="BDCG_06231"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06231"/>
    <dbReference type="OMA" id="VFSEWRA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="121"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT01870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="530" mass="59019" checksum="8069D41F819697B9" modified="2016-09-07" version="1">MSKRMQKEMAKEEMLRRQREAAAVPKHAPRLPDLPAPPQLNTFGGENARQEHLTVTSNRGGSYIDPNAPASPYASAAGVRNSEIVDPYARTESMTHRGRYSYASSAVSTINSPRRVRRRKDPTPYNILVIGARKSGKTSFLNFLRTSLQLPPKKRPTRAPDEFDEPQQVSAANNNFTSHYLETEIDGERVGLTLWDSQGLESNVVDLQLRGITTFLESKFEETFNEEMKVIRAPGVRDTHIHCAFLILDPSRLDANIAAAHESMEDPEKSSSVRLIGGLDENLDIQVIRTMQGMTTVVPIISKADTITTGHMAFLKKTVWESLKKACLDPLEVLTLEDQDDTSSSDGLDKFDEQDEDELIQREDAEAEADAQAQAHGEAGAEMDGGVVKPTTGRRTPDSDTVPMSLPITQSPSSRQNNGTSISSINANINANPEYPFLPLSILSPDPHSLEDNNGPIGRKFPWGFADPYNPEHCDFVKLKDTVFGEWRGELREASREVWYERWRTSRLNNNGLENISTIAALSREFQSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U297</accession>
    <name>A0A179U297_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sister chromatid cohesion protein Dcc1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01843">
        <property type="protein sequence ID" value="OAT01843"/>
        <property type="gene ID" value="BDCG_06170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06170"/>
    <dbReference type="OMA" id="YRIRQVQ"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="327" mass="35957" checksum="8C8E43DF835F825E" modified="2016-09-07" version="1">MVRHVHSSNCIYLIQPAPSTQPEPQQATGETPRHHITTIAKCNATLELVKLDSNPYSALPYLQRSLRVYSGTHAEEDADVDMSDAGNGNGTGAVSTAIATETAGDKSSIVQRERRRAITKVFGDVPFSPVECERGWVEVCGFVHKARHSGGGGDDGRLACWSPSAVVKIQTWKNILDGAVLQGINMEKQFLVQDLWRAVRVGDAGFPRPLFDALVRRLMGDPASLGLGEVYEELKWASLDKDTTVSWVGEVYLEANAPDPTMAIGRAEFLESWKDLLPESWRSEATWDNLKSDSHQYPGPASVCYKPRLETQARRTGLKACVKHGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2E8</accession>
    <name>A0A179U2E8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 oxidoreductase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02244">
        <property type="protein sequence ID" value="OAT02244"/>
        <property type="gene ID" value="BDCG_07097"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07097"/>
    <dbReference type="OMA" id="IVHECNR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="545" mass="61147" checksum="A7EC256617585712" modified="2016-09-07" version="1">MSLPIVGGISVLESYVLQRTVFPESAFYGLCLRVLALNIALKLLYHVVIWPRFLSPLRHLPVVKGRLNMAKLVFDEPCGKLPLKWMKTIPNNGLLYFRNSIGHNCLLLTNHAALLDVMSTNTYDFEKPGKVRAFLARIIGHGLILSEGAIHKKHRKAINPAFNIKNIRALYTLMWEKTGLLLKELEKDLKEHPWEGVGGAQGMGKVEMGEWARRLTLDIIGPAAMGRDFRSMQSSEHAVVDAFLSILEPTKEKIAFLNVNFLFPQWFTQRLPWSINEVITEKTDFLRSLCLDVVQEKKAALISSKATAKELETDILGTMMVGGDFSDDELVEQMLTFLAAGHETTASALTWACYLLTKHPDIQTRLRAEIRARIPSGNSPITYADLESLPLLNGVCQEVLRLYPTVPMTVRESIRDTSIAGNHVPKGTRILICPYAINRSPTFWGETGEQFLPQRWIDVKPDGTESVNHHGGAATNFAQITFLHGQRSCIGKDFARAELRCALAGVVGRFRFEMQDPKQRIRIAGAVTTKPVEGMHLKMERVEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2X4</accession>
    <name>A0A179U2X4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 allantoate transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_05709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
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        <property type="protein sequence ID" value="OAT01638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622884.1"/>
    <dbReference type="EnsemblFungi" id="OAT01638">
        <property type="protein sequence ID" value="OAT01638"/>
        <property type="gene ID" value="BDCG_05709"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05709"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT01638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="526" mass="57060" checksum="A827EF36C3D794E5" modified="2016-09-07" version="1">MWKSRLRYISGYWTVSGSCIFAWTIGSTLLAFGLSPQQAIACVVVGGILTGLLAVACGWMGERQQIGFTVASRFSWGMRGSYFPVLLRAFVGSMWFGMQSFWGGQATRVLIGAIIPGFAHMKNYFAESSHLTTNDFIGVVIWYAAFIPLCLIPPERLQKPFAISFVLFASSCIGMLIWGVENAHGPGSMFHKPASTPSVTWGMLYGISAILGAWGAGTLAQSDWTRYANRPLAPTLSQLVAAPVTIAVTAIVGIIVTSAANDLLGEIMWNPIYLIAAIQEEYESSARARVGVFFASVGMVATQLAISVVLNSISTGMDMAGLCPKYINIVRGSYIMAFIGFCSQPWQLLATATKFLSVVSGFGIFMASLTGIMLADYHVIRRHKLKIDDLYTGDPGSIYWYWHGFNWRAVVAFVSGVWPLFPGLIASINNITHPGLANWIKLFNLTFFVGLAVSFASMATVCYIWPPRGLGEEAPFISHMQRADGVDSVLVGREDIAAGQGRSGLDGVVRVDLKDDGALRGVERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
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    <name>A0A179U2Z2_AJEDR</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="PTHR14094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="402" mass="44665" checksum="A0D79346E48B8C22" modified="2016-09-07" version="1">MLKPKRFQTYRAENFRRTAEVYKELSTENPAFVGEKNDLRINSRAADAQLQWSGLASQVDNTRPSREELESFETTYNVACGAIGRGELETGEVLLRRAKELCKSSEDLTPKDKVAELLPIAVQQLYIALKQGKSDEAKSLADEINIAEIPEISTKKIAQNNILLASQAQSNPYILHKQFHQIPTSIDGDRLFSFQSRPLTGNSFVVDLLVRKFEGIQRSTEKALSQHPAPTTSPDINALSVFNIASHARDGSGKAGLKEVLPLLAKRPNDIGLVLTLIQLYVSARNVNSAISVLEAFFKRLDQSISESDKDIRFNPGLIGILVSLYKIQGRKSHIKTDSPKPHHTGNRVLTNLPLSFAPRAPRSSHPVSPQTLPWQGKYSQNSIPPIQMTNLQPQATFLRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U395</accession>
    <name>A0A179U395_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="106" mass="11588" checksum="D25F270312DBE08D" modified="2016-09-07" version="1">MGNGCTAMAIQKRIQKLQGAGAKDASESSPRLTPNQSALTGRTTINEAFDGAARSSTPEPKKRKMVVQDHSEDEDQTFDSPTKRLKLGKMGQIKLEPTNETVEHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3Z0</accession>
    <name>A0A179U3Z0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl CoA binding protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_08268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02755">
        <property type="protein sequence ID" value="OAT02755"/>
        <property type="gene ID" value="BDCG_08268"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08268"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="SSF47027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="370" mass="42657" checksum="4CCB1E5986A0192E" modified="2016-09-07" version="1">MDRPVDDETDLHAEREKWDAWYAQRHLSRTEAKRQYITALLDTMNKYASSTPEARELISELEFVWDQIKSNSSSSHSSGSPIHTSNVSQPQRQPSRVASPTPPSRSNYGSQYGSIGGRISRGEAAAAEEGMERPIYAGRDSRLRVLSPVSQPDDEVPGSGRRNYKAGDEHGAGPDGDRLEEKEDEDEEDDEDEEEFQEARDSPFEDDDDNENDDDDEDVRSDNNNNHNHNNGTQQQPRGRNRDRDKDTPKPKATTYNRRWRRRVEQAMTKMTAELAAMREQMETRAINSRRRSSLWAWIKWLVWVVVRQVCWDLVLFGCLLVWMRVVRGDRRLEEKVSGVEIWKEVRRRVALVIGRGERRGLGFRLGGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3Z6</accession>
    <name>A0A179U3Z6_AJEDR</name>
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        <submittedName>
            <fullName evidence="3">Meiosis specific protein Hop1, variant 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDCG_08289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02765">
        <property type="protein sequence ID" value="OAT02765"/>
        <property type="gene ID" value="BDCG_08289"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08289"/>
    <dbReference type="OMA" id="HACYQCL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="SSF56019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="684" mass="75318" checksum="5EFCC1AB494170D0" modified="2016-09-07" version="1">MEIFDAIEKNFLEALQMTIFVDKTKSSHVLESYTFTFKYTPAATGGGGCKQKDGGDDVGKQLASVSLESTGCTADMKTVKTARHGLEMIVRRLITLSAFLPMLPNERYMELHLFYTDGSPPGYEPPGFKAAEHNDLLFAQNEMWSRETQSCGAMETGIHSVGLKISSLKWSGTDYPSSEYVPEIPADIGYSNRVRRDEDIGISEMDVAVQDLGLSTQGSSQVSTQTRQDEAFKKDLQKMIPPVTSTPDSDFIPTQRNPDCLQIATAKPQLSQVKLSQLGARNQMFSGETSLHYDQNKGHSGHINPDVVRCECGSNSENRDMLQCAFCKTRQHLTCYGFIHAQDPAIPETHACYKCLLEPQERHLVQDMRTLVLLRRALRVIIEEGYPNRVRDFAQKLNCNGQTIVQITDMLRKQGFLLATPGSKSKGFLEKGLPKFTLSTETAVKQRLRNEIFNPLAKITHHYNLPDNQNRRVGQRARSVELSSGVSSDVLSIEEIPPGSPGYEERRRKSKIGGTTNATGKVPTPEVNEIRSAWKALGSSLDSVKPVQPSGDSQTETQTQTQTQAQAQKRKPNRSIMGDESGFGFGSASDRGDRHAWQGFTRRQKQTRTAEWVDDFDDDDDDGEGIMASGSDGENGTATNRRKRVRLSKLGSPISIFEPSSESGMGSGSEGDGGSGSRSASGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3Z8</accession>
    <name>A0A179U3Z8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AT hook domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02403">
        <property type="protein sequence ID" value="OAT02403"/>
        <property type="gene ID" value="BDCG_07414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07414"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="652" mass="73744" checksum="9CA824D2290FDF5F" modified="2016-09-07" version="1">MFGAPNILPPGAPPTTAEPEPTIPRTQPSSSRRTPTPDSRRRTSPQITRRTPTRSQDPSSSRSTPGSRTNTLPRRTSVFDIPPDDDPDHGREHKRRRIAVPSEPIPEDTVIRSDIRETEPRTTARDARSSPNTQSGLSEAEHERREPSAERGQNREESDAQPAPDGQPEIQNAEPVDTLQEKGQPHPPKKRLQSKRRKSVVQGYKRRKRASVVDQLRREPDHEPEPEPEPEPEPEPEPDLEPEKESEPVLEPEPEPHDLDEGDVEEPAAEPVELPTRKYRKRKSVWQIATKTKHRLPRDPVEASENQAEEQIPASEELDQNPVDEVNDKESAGHEEDLQGQSTSPDRTTKPKRKSSRAVKERSRQARQLQPEDAVEERTPAEPSQPKPPQRKQRRQKPTEYQNTENEPKPRGSTVPVIVHRFANLAALQSMTGDDEGTPSETAQADDPSGRHKYPSRSGVNPADVLGQICRETLEKTASKLADGIKQESNASRRAEWTRKRKAVELFGAELEQRLFDMSELLDSNFVLSARLKREKQDLASLRNRLIALRKEREDVALRIDEVRRKYAEDEQLKMAHDNLNNSLHDLQLAMDRGRKVDDEHSADPTIGLEFLLRTVAQNVSSTAPGSHSGILNQIRVFNSQLERTAALLEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3Z9</accession>
    <name>A0A179U3Z9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis specific protein Hop1, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02766">
        <property type="protein sequence ID" value="OAT02766"/>
        <property type="gene ID" value="BDCG_08289"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08289"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="SSF56019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="500" mass="55815" checksum="39C93982E509A9F7" modified="2016-09-07" version="1">MEIFDAIEKNFLEALQMTIFVDKTKSSHVLESYTFTFKYTPAATGGGGCKQKDGGDDVGKQLASVSLESTGCTADMKTVKTARHGLEMIVRRLITLSAFLPMLPNERYMELHLFYTDGSPPGYEPPGFKAAEHNDLLFAQNEMWSRETQSCGAMETGIHSVGLKISSLKWSGTDYPSSEYVPEIPADIGYSNRVRRDEDIGISEMDVAVQDLGLSTQGSSQVSTQTRQDEAFKKDLQKMIPPVTSTPDSDFIPTQRNPDCLQIATAKPQLSQVKLSQLGARNQMFSGETSLHYDQNKGHSGHINPDVVRCECGSNSENRDMLQCAFCKTRQHLTCYGFIHAQDPAIPETHACYKCLLEPQERHLVQDMRTLVLLRRALRVIIEEGYPNRVRDFAQKLNCNGQTIVQITDMLRKQGFLLATPGSKSKGFLEKGLPKFTLSTETAVKQRLRNEIFNPLAKITHHYNLPDNQNRRVGQRARSVELSSGVSSDVLSIEEIPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5A7</accession>
    <name>A0A179U5A7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02518">
        <property type="protein sequence ID" value="OAT02518"/>
        <property type="gene ID" value="BDCG_07662"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07662"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="671" mass="72705" checksum="19F7B66859A46089" modified="2016-09-07" version="1">MSRQSAAARMADPAGGVPQQLLPHMHLVSNYRYPVMNNLSHDTAVEYLISAPKVVRELQTVHWMFLDGPPDGTVMLVWQPLNHLGTTFASDGYVWADAELLYSTEIRGYNLELYLQRCGYHPPNEQIATHCRKRYRLTPTKNPNANVLPCDPSLWIIHYSKAPAGDHIPSNQIPATLQMQNILAQRRFLQSQGQLVRKDFMLHDRNSWPTINLPSQVGQQNFAQQGAPYTNPLLSRQQSGPFYQPQQGQNLPGPQSKQSRSSRTATAAAAMASAAAGDYSLEEEEVSTGDLLDTITPRDISKMRYRHHHEWMDEIFGSPYSVKQIMPVDLGLGRKGELESLTSGFFDAPTGPSLTQKELSAPRSTGKMEPGKAEDFTHAANRRISEITGEIEKMKQKHAKRLEKMKRITLLKEAELALRDAYIDPEDVGNEFWRVEGHLDISAREESPQIEYSDNRPKTRVDDIISNLEKTLGKSIVPVTEVSCIEEGGLQKRVAPPQIPSSAAVRDVDMGDAGISLPGEAADSAQQQPSGGTSAGPVPAPVTAPTARQTKDEKASTLPPATQTVSASGPSFPSEPSKPGPSVDVEMGGIEVAKAHPTTTTAGGQVTGESMVNKEENAAPQDTSVNVAAAIEEPSTTTESTSAGAAATAAPILAQPPATTTTTPAAAKPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5B1</accession>
    <name>A0A179U5B1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDCG_09344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999987">
        <property type="protein sequence ID" value="OAT03184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03184">
        <property type="protein sequence ID" value="OAT03184"/>
        <property type="gene ID" value="BDCG_09344"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09344"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048478">
        <property type="term" value="P:replication fork protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="PTHR13220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swi3" evidence="10">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAT03184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="278" mass="30744" checksum="0CECEDF205AAC611" modified="2016-09-07" version="1">MRRSKLRPRDDRLRNWTRLLSPAGIPKLRKNAKTKLKFRGKGHEYSDAMRLLNFYQLWLDDLYPRAKFADGLAMIEKLGHSKRIQIMRKEWIDEGKPRLYAADRDEETNNDTTQLPASNAAAASSDGHPQTENDNELFPATTTNTARRDPRTSPVQRNNSTVDSSTENHIPSIFGGGEGGKGKAAEHYNADSDDDLFVRGDHNDNAHVDINKLAGHVENSPEDDELEALLAEHEGAGMPSGLESKPSTTTTAMAKGSGSGLPPVSAFDDLDAMDDYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5B9</accession>
    <name>A0A179U5B9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA interference and silencing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_09384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999987">
        <property type="protein sequence ID" value="OAT03194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03194">
        <property type="protein sequence ID" value="OAT03194"/>
        <property type="gene ID" value="BDCG_09384"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09384"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="SSF101690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="436"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT03194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="833" mass="91313" checksum="551D5826C2793F77" modified="2016-09-07" version="1">MYTLKVTRTGTLQVSALVDYLSSTSANAVFGGKEEVIQALNVVMGYYPKDSEHIANVGTNKHFFIKPPDVEKWDLTGGLEVLRGFFGSVRAATARILLNVQISNVAVFAEGPLPRVMMSFFQSYGHSMGKLDRFLKSVRVQLTHMKKVGSDGREVLPIKTILGVATIDDGRGMKNKPRVQRVGAGPKDVTFYKEPNADDEMLGANTSSTAGAYVSVFEFFRDIRKITLENPDLPVVNIGSRERPIYLPPDVCIVLPGQAPNMTLSTTQTQQMIKFAVRRPALNAKSINTKGAQILGASQPANSTLAGFGLAVQPGLITVPGRVLQGPQVRYKSVGRDARPPTNPNSGSWNLQRNQFSVAKPLKNWACLWIQKRDTSLPWPDAETLSSQALDPFIRQLKQLGMTVDQPLIHICPDDFERSIEEHIASVLQFKPSLQLIFFILPVVSSIYSRIKYLCDVKWGVHSICVVAGKFAKERNCQYFSNVALKFNLKLGGTNHTLDPSKLGFISEGKTMVVGLDVTHPSPGSSSNAPSIAAIVASIDQDLTQWPADVRIQPSRQEMVSGLDELLKSRLRLWAKHHRTAYPENILVYRDGVSEGQYNTVLNEELPLLQKACRSLYPAQQTRRGLPRLSIIIVGKRHNTRFFASAPAAADRSFNPRNGTVVDRAVTDARNWDFFLQAHTALHGTARPGHYYLVYDEIFRSSVVKPSLARLTGGIGANVADAVEALTHNMCYLFGRATKSVSVCPPAYYADLVCTRARCYLSRLFEAGSAAGSVAAGSVAGGGRSMSSLEVGLAKLSTAMPQGGEGDGGNDQQEARVSEVRIHELVRDSMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6B0</accession>
    <name>A0A179U6B0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TMEM1 family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_08523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02858">
        <property type="protein sequence ID" value="OAT02858"/>
        <property type="gene ID" value="BDCG_08523"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08523"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPP_II_complex_TRAPPC10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="PTHR13251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1166" mass="129521" checksum="0ECCE087F50BEC81" modified="2016-09-07" version="1">MKAEKALGLIPGEDDEGEWKHYDDSHEDDSEDSDATDDFPYIALNEELFPLDPNKKPYREMILANNISVFDFRVYIFARQMMLLLKAARAPSIQSGSSQTTGKPAKEAVNLTLLAEICERASEFISIGSRTLRHDLYAGLDELEHECDESSVVDILNNIVYSWTYSAISQVLIQTATDSLDIPKASLRNTRDLVNASVLANFVAESRPGVPKRSSSLTANTLISSRPTSLDIMSPGVYSGAQPRAPLASLKSDGSVQQRTGQSELASSRGDLFLYARRTLENIAQRRGWSKKWRDLGLLFDEHNAPIMGLKDVALDEDGETQDSTTTEQKVVPVLRAIENPSMMRACRSEKHFGSIYEGLTDQIFRHYLAANRTRSAEMAMADIAVLRYRAGDYATAASFFHQMAPFYASCRWGVLEGVMLELYGRCLKHLGRKDDYVRVLLKLLGNYAGVAQSGRKTGAPQGKRISSAAPSSFSPVARTLASSYVDDLFEVSQSLPTEFSVPLNEFFGGIDISPTIHHFEDKDGILVELSLRFLLGSSIDVDNVKMRLVNSAGVHNSEIWLENVDDVVVKSTTSRILLHSFVSVHGKYLVDRIEVRVGNFVFVQHHGLPPQFRPGLREPDADESDEEDERPFVFCYPPAKGLQAKISPPYRINLSDLRTIEIELKSGWNNILKGVLRVKPATAGLRLRITEANIVDGPIKLAENAESGQIDFTDFGPNSSARLSIPYTLEDDQTSLSARLEVIYETPEGQFSYFSSTSIVSMLPVSVNVQDMFKDDSLMSRFTISPAMVTPLRILNCEIPSSEVYEVQSSIHRWEVLDVFPRQPASLLYKITPREDKPLQADASKRSLALTIDFACLDEECLHAIEDRFVRDIGSSKFEQLARLLTPRLLDAFRSAWTANDLETISLIREIDMLPYERVQWEAVTNSLSGNFGKEVVSWLKEWHMQNPTLPLPHNSNGTTTTTTTIPNRQIIIPVDIPEVQIVHTANLTVAQPNHLTHATVGEMIPATLAIHHTRRWCPPQHREPESSLEFSYELLVNPDIWLVGGRRRGNFTATEGERRTFTVMLLPQRPGHLLLPGLEVKTFVTQAPAGGEAELVSGAVQRRVVPCEVDYQNHAETVLVSPNLQKTTVNLDVSGGTGAGVGGSSGSSSGSWLVESERRVEVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6B4</accession>
    <name>A0A179U6B4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Murein transglycosylase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02511">
        <property type="protein sequence ID" value="OAT02511"/>
        <property type="gene ID" value="BDCG_07646"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07646"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107216" evidence="2">
        <location>
            <begin position="25"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="33"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="370" mass="39129" checksum="CB037A9CFA0BDB93" modified="2016-09-07" version="1">MKLSSGSVAALAMSLFSGSSLVAAQTWTACNPMQKTCPPNPALGGTADFEFHTASARFDILGGSPSYGADGASLAVAKQGDSPTLISKFYIMFGHVEFVIKAASGRGIVSSAVLQSDTLDEVDWEWLGVDNGRVQTNYFGKNQQGTFDRGQFHSNPGNQNGYHTYSIDWDSQRILWQIDGSTVRTLTAAEAGASYPQTPMQVKAGVWAGGDPTNPPGTIEWAGGPTDYSAGPYVMGLKSIAVTDYSTGTEYRYTDTSGNWGSIEAVGGKVNGRGTPGSGQQVESSIPPAEATRPPPTKGIIHPSGYPWVPSTTHKPKSTPSITSYPGLPSDWIVTDSGRASTPSTASVKNIPAYFAVVAFIFGLFFRSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7A2</accession>
    <name>A0A179U7A2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02831">
        <property type="protein sequence ID" value="OAT02831"/>
        <property type="gene ID" value="BDCG_08459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08459"/>
    <dbReference type="eggNOG" id="ENOG502QT5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EKWLRIS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="319" mass="36035" checksum="ACB90D7F4BB8FF5F" modified="2016-09-07" version="1">MPSYTDGRGGLKISFSDVFKSSKTIREEMAAAAYKKAAVAAKAKKATAELAARTTKAGGYPGGFHNASAPVISPGYPPLVYVSVPRRDAAQMNWSQSPTQYHAIPQMSADQVQTSQTNTGASASPTLQQQQVQQQQQQQQQQQQQHQQPPQPPPQLPQQEWTTDDDDTLRRLKAEGMTWKAISTSMDRPVQALKTRWGIVRPAVEYQIQRPHTSAQCETSSRSQQQQAETQRRHERRVSFAEPLIMNGKNDTTSITYPRAPKKKILYVDENFSLEEILLLNKLAVQYEEEKWLRISSRFYDKTGKRLTPQEAREHVQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7B1</accession>
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        <name type="synonym">Blastomyces dermatitidis</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAT03097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03097">
        <property type="protein sequence ID" value="OAT03097"/>
        <property type="gene ID" value="BDCG_09136"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09136"/>
    <dbReference type="OMA" id="CFNSDKV"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12528">
        <property type="entry name" value="RRM2_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034863">
        <property type="entry name" value="Fungal_Mei2-like_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="470"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="64"/>
            <end position="93"/>
        </location>
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            <begin position="364"/>
            <end position="411"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="375"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAT03097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="698" mass="77207" checksum="10E7381F70182114" modified="2016-09-07" version="1">MRGNGSSAIASSPRSSDEAASRNGSPETKLTAFSPEDLRLKSRFEAGRAFCGPPDDSHRPFYSINNGLGHHQGQDPFLSTPSSAGRAQLSPTASSFTPSGFSINPFGFSARSAFHGDQQPQPMAKGYLAATSEPDASPDASDVFGTRSNLRLSGFGPIGKAKLVKSPLPMMFAHLGKFDGENRNRAFAIDGVPANLPYLTLAEIFNRREFGTLKGPVFTELSSAGCIYLGFTDIRDAKNASEKVRRLHPEWRIRSLTAREYAQKFDPANAGLVSDFEGQVFASVFYDSSNPSLDARVVSHSFKDLLETFGDIKAFHGMPNTQGNVDEFLIEFFDTRAADNVVSTLNGTSVDECVLELKLHRPDMAEPQTPRHGSFESRDFFSSSDVSNKRPYSRRSMTHMHSSPYHELSPTGRSIIPIDDHVATMGWMPKADDNFGFRPRHELSRHSDPRSNNQNFVDIERIRCGVDVRTTIMLRNIPNKIDQAMLKEIVDETSHGKYDFMYLRIDFANNCNVGYAFINFEDPIDIIDFAKARAGHTWNCFNSDKIAEISYATIQGKDCLVQKFRNSSVMLEHPSFRPKIFHTGTGPLAGSEDRFPGPDNPSKMRRSVENAEHVGLFAPRVGQQYRDEQRRRRSQFDRGTTAAEREAYYVRSSSSFTPRRGALNGNGNGGVMLPMMVMSPCYEGPVSGADGGVGARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7C4</accession>
    <name>A0A179U7C4_AJEDR</name>
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        <submittedName>
            <fullName evidence="3">AT hook domain-containing protein, variant 1</fullName>
        </submittedName>
    </protein>
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            <taxon>Eurotiomycetidae</taxon>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02402">
        <property type="protein sequence ID" value="OAT02402"/>
        <property type="gene ID" value="BDCG_07414"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07414"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
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        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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        </location>
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        <location>
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            <end position="187"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="681" mass="77053" checksum="8F0FFE7F96BB3806" modified="2016-09-07" version="1">MASNREERRLMRQRGAGNRAAKDIDFGFGSMFGAPNILPPGAPPTTAEPEPTIPRTQPSSSRRTPTPDSRRRTSPQITRRTPTRSQDPSSSRSTPGSRTNTLPRRTSVFDIPPDDDPDHGREHKRRRIVPSEPIPEDTVIRSDIRETEPRTTARDARSSPNTQSGLSEAEHERREPSAERGQNREESDAQPAPDGQPEIQNAEPVDTLQEKGQPHPPKKRLQSKRRKSVVQGYKRRKRASVVDQLRREPDHEPEPEPEPEPEPEPEPDLEPEKESEPVLEPEPEPHDLDEGDVEEPAAEPVELPTRKYRKRKSVWQIATKTKHRLPRDPVEASENQAEEQIPASEELDQNPVDEVNDKESAGHEEDLQGQSTSPDRTTKPKRKSSRAVKERSRQARQLQPEDAVEERTPAEPSQPKPPQRKQRRQKPTEYQNTENEPKPRGSTVPVIVHRFANLAALQSMTGDDEGTPSETAQADDPSGRHKYPSRSGVNPADVLGQICRETLEKTASKLADGIKQESNASRRAEWTRKRKAVELFGAELEQRLFDMSELLDSNFVLSARLKREKQDLASLRNRLIALRKEREDVALRIDEVRRKYAEDEQLKMAHDNLNNSLHDLQLAMDRGRKVDDEHSADPTIGLEFLLRTVAQNVSSTAPGSHSGILNQIRVFNSQLERTAALLEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7D0</accession>
    <name>A0A179U7D0_AJEDR</name>
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        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Ajellomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT03117"/>
        <property type="gene ID" value="BDCG_09199"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09199"/>
    <dbReference type="OMA" id="NSNFDWH"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT03117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="882" mass="96146" checksum="461E9A27E531E64E" modified="2016-09-07" version="1">MFDSVPSAIGINTRNSKDNKNHGKKSIDKNNNTPYPSASASASASTSSFSSPGSQWYYNQSCDHLPPPMSSTSTVPESPAVGRSRSSTRSPIRLSVFGARSRSNTATSSSSSYKSPASSLTSGDSASRRSSQDGRTLSSATSLVSEKEASTAKSFLSRGSRILRRKGSKFSISSTLTLDEEDEMARGSHSASQRMDGVGIFHRSHRSRHSGTHSLKQNISDPFDFQHVTHTSPSQLPPMDSCQLDDIVTEFSVIRASQRPGHELKGIRAESLHFQNFSSDNISIKNDASPCTSDSRSQHAHSRPTSSDVRTSPTSPSRLQSHLNSRSVENFSRPVSRLSRQQSSPSMIAPPRSSSKLATPDIPEPSPQTIDALLGLHSTFAVPETLYDDTQEQHLPKLDLPSVFPDVGHTLIPDDDMPVMTRSPSNILAFDLADVPEEDETAMSRNNDARNSTIATSSEPFRFGQSTPRVDFDKPLPAVPSPKQLIPEPLGSPTIPTLHGDSNEAFAQKRWKSNKRRSIFQRPLDDLSWEDDIDYCYEHAAESNSNFDWRRTSFEEVEMKSKLERLTIHASPAADPDTPIAIQNQGSREGSEHSDQNTINASSFSAPSFTTPNYDVTPMTSTSPLPCVQIDTLSQADYFRDEHVPILSSPFGDDIVSSQAYHGLIPIDQKVDENYPLYAHVQVDEPFDSPRGSCSEISKCNSEESIILSRAASVARKHRSSLSTTSVPELVHSSNCSHSALDRDSVCSAGEQHPQQQTKETLPAPTLSPVPRPRPITTHQRSKSLARELTQRSNPSISPNSIDSYTSGISSAPTMPYHDRAKSVSALDLRQPTSPVKSKAPEPRKRSATITRGSSGRRARKSYSLFPTAAAAAPAPVAPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C5G9J2</accession>
    <name>C5G9J2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="EEQ83762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ83762">
        <property type="protein sequence ID" value="EEQ83762"/>
        <property type="gene ID" value="BDCG_00567"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00567"/>
    <dbReference type="HOGENOM" id="CLU_005382_2_1_1"/>
    <dbReference type="OMA" id="AIHDWHA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="PTHR47803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ83762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="504" mass="55345" checksum="02BE25D029EE2BEB" modified="2009-07-28" version="1">MVLHDSHAEILAIRAFNNWLLEECKSLLEHRIDYSNHEFKSERIEANEANNNDEAGTQPTCGKLHASKFINWRHQPGTGPNLASHTLSRISDTNQLAKTKHSWPPFELRKDLRIYMYGTCAPCGDVSMELCMASQEDPTPWATPPLGASNNPENSSGNSSQHNQANNIPHTTTSLLNGRAHFSILGAVRRKPSRADAESTLSKSCSDKLAVKQVTSLLTFPACLLIFPSSNAYLTALLLPEEEISRVACARAFGSGETGRLGELNGRRWSDDDPGVDDDDTAASLGGMGYTFRPFEVRPVPTAQVQEEWAFGKPKDNNGAEKKSKPGNISAVWTAAPSSSTAINGKLATGTKLNETLINGVKQGYRISSPTPRKASALSRAKMWGLLRDIVQLLPSADNCGENDGVAAQTGKFENQTSTTRRALDHIHDNSLFAKMKECVLTAQSYELMKRKCIKMGIGPSKLRKNVTTDVREVLGNWVENRGDDDWGLELLEESSTRKVVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C5GB63</accession>
    <name>C5GB63_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_01390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="EEQ86270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002620107.1"/>
    <dbReference type="EnsemblFungi" id="EEQ86270">
        <property type="protein sequence ID" value="EEQ86270"/>
        <property type="gene ID" value="BDCG_01390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01390"/>
    <dbReference type="eggNOG" id="KOG0707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_0_3_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ86270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="201" mass="22458" checksum="7F132C10A0A74A21" modified="2009-07-28" version="1">MAASAAVRRFRPVVISGPSGTGKSTLIKRLFADYPDTFALSVSHTTRAPRPGEQDGREYYFTTRDAFQSLIDEGGFIEWAQFSGNYYGTSTKAVRDVAEKKRICILDIEMEGVKQVKRTTLNARFLFLAPPSLETLEQRLRNRGTETEESLSSRLAQAKNELEYAKQPGAHDVVIVNDELETAYKALRDWVVDGGKFGALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C5GD40</accession>
    <name>C5GD40_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="EEQ86497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ86497">
        <property type="protein sequence ID" value="EEQ86497"/>
        <property type="gene ID" value="BDCG_01617"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99935">
        <property type="protein sequence ID" value="OAS99935"/>
        <property type="gene ID" value="BDCG_01617"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01617"/>
    <dbReference type="eggNOG" id="ENOG502SECU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103823_0_0_1"/>
    <dbReference type="OMA" id="PGENRWR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ86497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="151" mass="16439" checksum="4F6D801ADE175550" modified="2009-07-28" version="1">MSGAGDDRWRGGRGLDQNRQHGQRHQGGNLRDRSLGGHQQDRHPHRGYGNNANATNSWGPLHGGPPQEQHIPVKSFNAAESKGALKQGYQNVGSRVPLVYKPTDKEVNNSRAASGPWGSRPNCMVNGKDFFLELRKQVSALRQSGNNPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C5GQ84</accession>
    <name>C5GQ84_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_06733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="EEQ91613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002624534.1"/>
    <dbReference type="EnsemblFungi" id="EEQ91613">
        <property type="protein sequence ID" value="EEQ91613"/>
        <property type="gene ID" value="BDCG_06733"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06733"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_3_2_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PTHR11266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ91613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="195" mass="21901" checksum="4C3F6488F462F081" modified="2009-07-28" version="1">MPLVNLVLDEKATFALDYIELIRFIICTLITTPFMVLWQDYLEATFPASPQDNARRIPAEMEGNSERTSNSNTTAKEVPHGGVQTNQPERKETQEPIQEKNTWNTISKILIDQTVGAGWSTALFIVTISALNGQDANAIQQSLFRDFVPIIIAGLKLWPMVSVISFTMVPPEKRVLTGNLFGMIWGIYLSLRTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>C5GQT0</accession>
    <name>C5GQT0_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_06929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="EEQ91809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002621712.1"/>
    <dbReference type="EnsemblFungi" id="EEQ91809">
        <property type="protein sequence ID" value="EEQ91809"/>
        <property type="gene ID" value="BDCG_06929"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06929"/>
    <dbReference type="HOGENOM" id="CLU_056590_0_0_1"/>
    <dbReference type="OMA" id="FIDICDT"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ91809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="274" mass="28677" checksum="E1482686ACEA9617" modified="2009-07-28" version="1">MSTIEDAKRNAAKEAVAKHYPPNPKFVGIGSGTTIVYVVEAIKALGVDTSSTGFVPTGYQSNQLVANAGLTPVAFDALPEGTVLDVAFDGADEVDDDLNCIKGGGACLFQEKLVALQAKEFICVADSRKLQPRLLTNWPSIPIEVAPMAVGRVTSELKKLGSPLPKLRTAPVNAGEQTQPVKTDQDFFLIDAPFPKLLLSSDVVQGQDGSGKNGVWEVTALAERIKLIPGVLEVGLFCGLTGPQAQATGGIGGQKPVAVYFGMPDGSVSVRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C5GQY7</accession>
    <name>C5GQY7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pisatin demethylase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="EEQ91865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ91865">
        <property type="protein sequence ID" value="EEQ91865"/>
        <property type="gene ID" value="BDCG_06985"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06985"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_11_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2 3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ91865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="493" mass="55669" checksum="7B6A1272131D830D" modified="2009-07-28" version="1">MLAGPPNAAIAACLAALGLWLIVNTVKVVQRLFFSPFRKVPGPLLAKITGAWMLCVDLAGRRVLKIHELHAKYGPVVQLGPNELSFSTAESIDIIYGTGTRFRKAPMYMTMGRPGVLHLSDPAAHRERRRLLNHAFAKQHLDEMEPVFHKSVRKIVARMDRARGKALDMRHWFKMYTLDNAGEAFLGASFGGLDSDEMPQYVKDFDLFLITWAIKSTFPFLAWFVQRIPHPKIKVAFGAEERIYQYGIDRFNEYIQKYGRVSKRRDLLTKMIGCKENDPDALADSDIAVEISNLGFAATDTTGTALLYLFWELARNPDLVERLRSELADLPLVDGVVVQHHSVSNLPFLDALISEGLRAYPPIPAGLLREAPIGGCMINGIYVPQGTVASTHTWTTHRNPEHFPNPDKFDPSRWLEGNVSDGMKKFWMPFSKGPRNCMGRTMGLFEMRILIATLVRRFNISIDDTMADDAMDITDHFLLIPKREKCLLRFTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>C5GQZ0</accession>
    <name>C5GQZ0_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="EEQ91868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002621773.1"/>
    <dbReference type="EnsemblFungi" id="EEQ91868">
        <property type="protein sequence ID" value="EEQ91868"/>
        <property type="gene ID" value="BDCG_06988"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06988"/>
    <dbReference type="HOGENOM" id="CLU_012774_2_0_1"/>
    <dbReference type="OMA" id="NDNILHP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="212"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ91868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="705" mass="76346" checksum="6B66C8013445C6D6" modified="2009-07-28" version="1">MASSVVLGKRLRNDNASVAISLRSSKRQAQVLPQPQIHEEEESNDENDELSIPHSTGCRSRQRRRGVTTTTKRRTLPVRNVRSKHTVPDKTIDESIPPSNTAIIPDENTRPYEFTTPKTPSRYRDALSHNNDNTKIKPVPVTPRHRVQVFSSGRPLTPRTPRMIASPAPVQTVYTPARQLFARSATPGRLVGRDSERQELSSFIQNAVQSRQGGCMYVSGPPGTGKSAMVDEVCQDLSVDVDLKKETIKIARINCASMTNSKDIYAKLADQLCEDPQLFKQSRTELLAGMFVQKKRTSSSATPSALYLVALDEIDHLLTTDVETLYTLFEWSLQPHSRLVLIGIANALDLTDRFLPRLKSKNMKPLLLPFLPYTASQIAGIISTRLRSLLPTSNNAKTTATIVPEDFTPFLHPAAIQLCARKVASQTGDLRKAFDIVRRTIDLVEQQTRQTQKPSSSYQSPSKIPLVENANLASSLISPPDTPSSSSSSSSSMTPATATVYTPVTAPRATVAHVARVTASAFGQGTVQRLQGLNLQQKAALCVLIALGRRKVDNRDSGILDTPSLSKSPRSTKSSVAAGVVAAPTVNELFVTYSGLCRRDKILQPLAATEFRDVIGSLETLGLVGEAQAQGRGRGSTSATGGVGGGPAGLRTPSKPKTPTRMAGRVTGAGADERMLVCFVGEGEVEKLICGEGEGILRGLFRAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>C5GRV3</accession>
    <name>C5GRV3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gpr1 family protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_07415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="EEQ92295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ92295">
        <property type="protein sequence ID" value="EEQ92295"/>
        <property type="gene ID" value="BDCG_07415"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07415"/>
    <dbReference type="HOGENOM" id="CLU_051062_1_1_1"/>
    <dbReference type="OMA" id="CGAGLPN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EEQ92295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="253" mass="26972" checksum="D38601DBFEB3D126" modified="2009-07-28" version="1">MSDKQLSGSTEGASYEDTKGGTIHQSHQGSASIVPILAYRKPANPIPLGLLGFATTTFVLSLHQCGAGLPDSNPLGRVGPDAAVFGLAFFFGGMSQIIAGIMAFTTGNTYGTTVHISYGSFWLSYTMFLIPSLGIKDAYAGDQRAFSFALGIYLVFWCLLTLMFLVASLRTNYATLGVFGLLVPAFFFLALANFLRTTHMDHAIRLNKTGGVFSFLCAFVAFYAGAAGLMAPETTFVHLPLGEMARPDESSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C5GS85</accession>
    <name>C5GS85_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="EEQ92018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002620430.1"/>
    <dbReference type="EnsemblFungi" id="EEQ92018">
        <property type="protein sequence ID" value="EEQ92018"/>
        <property type="gene ID" value="BDCG_07138"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07138"/>
    <dbReference type="eggNOG" id="ENOG502RYEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018542_0_2_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="62"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ92018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="405" mass="45079" checksum="B4962C0F3F97EC3A" modified="2009-07-28" version="1">MNASHSDSHDEYHPDTTLTPSHDASAYNRGVSFDTFDNRDATDFSLTLNYKHRDYHPTRRSRTFLCGTDQNDYSDFALEWLIDELVDDGDEIVCLRVVEKDSKVASDASVEERRYRQEAQKLLDQVIAKNSDEKAISLVLEYAAGKVQEIIQRMIQIYEPAVLIVGTRGRSLGGMQGLLPGSVSKYCLQQSPIPVIVVRPSTKREKKKQKRLANPTRQRYNHVLRLNDMKSGRLFDKSRSTDSIVTKLPEEEAAVAHAIGVQDIGGGPAGAHTGRGPRLSFSRDTAFRTITDDNDYDMDGDRRSSSIPNSESTASGLSSALRNQRIESPAMTDDEGDEDERDTGGDDNDDNEPRERAHVSSAPNGRRQRSSEDATTTSTPPKKPPLVPITNVTVTEYTPNVDEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUL1</accession>
    <name>A0A179TUL1_AJEDR</name>
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        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">BDCG_00728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99555">
        <property type="protein sequence ID" value="OAS99555"/>
        <property type="gene ID" value="BDCG_00728"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00728"/>
    <dbReference type="OMA" id="EDNFTER"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="353"/>
            <end position="397"/>
        </location>
    </feature>
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        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
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            <begin position="15"/>
            <end position="31"/>
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    </feature>
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        <location>
            <begin position="365"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="609" mass="69210" checksum="39B57E51C0179DD9" modified="2016-09-07" version="1">MVNLRSGGTPDLTKEYVPSRRKNEKTPEQQTQDHRSLPTPITNRKAAPGAFEPDETIAEEQSDESNVYEDPVEGIISEMSGNAGGPSGRNDNSSASEETRMRLEIARLQHEVERMKTSRGDPAGDEMGADLAEYLQRKGKTSVIMKVLEEFRSQVRLIKRPIVLTGSINYPMWREEILLAAEQSETDDILEGNGLGENATMDMQRFWKERNLWLYNYMWSAIAPQAKAHFTIPKESKLSAYALWTIIEDNFSERPAVRRTRLFEELIGMTSKSKGSDRAFIERLIAIRTDYIRLGYKIEDVVFFDRLLTGVNRGWASFIKNRMDQIDKDNSRPLEEDFMGLCRDILLRLPTAENSSTESTRNPINNAQDKDKKAKDKEKDNDKDKDTESKPERRGNDARTCYHCQKVGHIQTDCWKKYPEKRPSNSNSNTNRNKDKDKDAENTGAAPVHNVMEQVFCIKEKAYASGQTGKDTWILDSGSGAHATPHRDLVVAKPQKVKVMLEMADGTVVPAAAIGDTKIPVEGADMLLNDVRYVPKLEVNLMSMGKLVRQGYTYKQLTYGNNHAMLIMSPDRMFSFTARLNENDIYEMERPVTYRDLIRTYDDAMASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUM6</accession>
    <name>A0A179TUM6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99575">
        <property type="protein sequence ID" value="OAS99575"/>
        <property type="gene ID" value="BDCG_00783"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00783"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="421" mass="47459" checksum="7918C7E3C02E482C" modified="2016-09-07" version="1">MAQDRQFAVDTQQRRQTNFTHGGRTFGPPPSTTPLGPSATLASAMPAAPIAPPVPPAPPPPPFGLRPRSNTPPLKSALRKPTPVPTTPTQKRSYERRRPAGGRTASPHAPGWFEVESPISSFAAPDSPSTTDSTSTDSFSLLDPFDHWAVGLFSRPTTATPLPFSNKGSKCHGDFDMPDALAQIEKDYDELFRLNFKPNLTAIFYLRDRDHRARILCQVHRSSSKIIYATLPLNVLILSRQDSYLLLCTKSSDGQGLRAWLSLEFETIEKMVLFHCAFIALRGQDSGCPISRIPDPFSLEEREIYGGRILDDSYLHALRIFQDHPSGAIRLQASIHSGEMADVPVWTAFIHHYVRSKSWMRRVDRKTIILSNLDRAIFIQRDKYRPRMTRHQEHVLTFAHEIDAEAFESEITILRHQSRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUM8</accession>
    <name>A0A179TUM8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LipA and NB-ARC domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99573">
        <property type="protein sequence ID" value="OAS99573"/>
        <property type="gene ID" value="BDCG_00774"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00774"/>
    <dbReference type="OMA" id="SIMHDLY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="376"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1446" mass="160858" checksum="A2D8348D4DF434EA" modified="2016-09-07" version="1">MYVSLTIYAGYRYSIVFVHGLNGTSYNTWATKKPDVFWPGDLLPHTLKGQNVRILTYGYDANVASFARGTSKERLHNHAEHLAGQLIANRNLQGAVERPIIFVCHSLGGIVVKRTLLYCEHLRHPKTQHLRSTYISTYAILFMGTPHNGSDLANLGSAIQTLFSLVPKKLFDTTPSLLKTLRPDNEILQNVNRQFAEIMGRFRIYFFHESKPMDLKGTRKFIVDESSAAPVIEGVERMGIEADHGAMCRFESKKSPGYEAVAEAILRYTKEAPGEIANRWIQEHRARRNNMREEAERLLYMDDIMRRSQSSLHTERLDSLGNSISSLHTGQNSELIPITRSQLMSSAELPPLQETGEPLLVAPPGFHPNWVFVGMEKELEELHNRLFRVKRRAEDVVSVLIYGGSGSGKTHLARQYVFNQRATYTGGIFWIDARSRESCCQCFWDIAERVSSTQQKESQDPDWRDRDKYIDKVLKWFGSRQNWLVIFDGLSCDDDDEINEFKKFIPYNTNSSIIYTSVDRTLWKKRRLFEPFGLKVRPLSVQDARTLLFKDLNIKQPTSEQLRKATELVEHFECLPLAIHAMGHRLSATGKAIEKFRIKPQTTDKRLAEPYRGIMADLQNNQHMEAVNLITILSFFGHDVPVGMIHLGRKALLECGVEIRAPEEEGSSERHIDNTFAILIRYGLIERALDPYVSNEHSPALRRSTELHDSHPSSELESSQTSGSQNPSSIGANTSIDVVKIHTVVQTFFRDELSRLGVGAFAWWLIVSTRLFLMSYNNATARIRIQQSPGLVKDFGQYETHSSVLLGLYKQLRPHKRNPDLPPDLVPLNHALSQVKNDISEEIKHRSPVASQQLMKHQKSIFDRTSSTSSMPDTPTSGSSRFTWEMDVDNDKTHSPIEYISSRKPLQHFPSTISQHLPLPVVEDQGYESDLEGSGTVPAMSPVPSQTTEVPESSAIAQDEGDWKVVTAKPKNPSFFGMVSRRLGIRRMRGQRNLGSYRPVHPVVSISGVHGHGSPSRPQNNDGEQEVSAKSQAEASLAAVRRANSPPARGGEIEKTNSKPAQKQNYPTYANVLAGRRPSATSSSGRSSPPIGWGSDSNKLSENSVPVHPGSAPAQYGWSPRSSSDHLTNSHHSEVGTGSSWKRPENERVLTPPSRFHSRHPSRSSEGSSGNILGLQDTVSQYQLAAPSNRPLPYEADITVTKPRYSSVVVPPQDTQGLGVASYLNTAAYGPSMGQSIPAGYSSQPMSRNVSGQSDQSLHTEPTRVPPRFSPDLGKRLSSPLVNVSQPGMSRLDTRSPQTSYGRGGGSAISSSPGTPNSLEPTAMSRASSGPGMIVDSGDGVTKSFVEFSHRPSTQNIRFGEHEPINIVDARMRSGLHERQTHPGQGSDHTALKHSTSPPYPDRNLMPSASDDNQLQSMARFPLENIGNLPVHGRFRSGSSPARPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVM0</accession>
    <name>A0A179TVM0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS multidrug resistance transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_00475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99462">
        <property type="protein sequence ID" value="OAS99462"/>
        <property type="gene ID" value="BDCG_00475"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00475"/>
    <dbReference type="OMA" id="RENMWLA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="23"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="476" mass="52752" checksum="D0DD6A9DB53C200D" modified="2016-09-07" version="1">MVDHVNNCNCSCGCTSRQRDILPLVFIPLSRLQTRFLTSFSFPAALGEVASSLNTTPTVTNLSIALYMLSMGICPLWWSTFSETFGRRSIYIISFSLFNVFNILSGVATSIEMLIVLRLLSGGAAASVQAIGAGTIADIWESRERGRAMGTFFLGPLCGPLLAPIIGGAMSQAWGWRSTQWFLTIYGGVSLLILTFGLPETLVSRKSLVAEVEPNAELSRTLSRVSSRQVAQNTAKWLKILRMIFVDPLQILLYLRFPAVLLTVLYGSITFGSLYVLNISIQTTFSQPPYNFPVLLIGLLYIPHSIGYIISSILGGMWMDSIMQREARKANRVDESGMYIYRPEDRMGENAWLGAFIYPAAMIWYGWTAEKHLFWAIPIIANFFFGVGSMIIFSMSTTMLTEFMPQRSSSGVAVNNFMRNIFSCVGGVVAAPIIHAIGNGWLFTILALVAFAAGSVIWAMRRFGPRWRLSMEARVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVM8</accession>
    <name>A0A179TVM8_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99915">
        <property type="protein sequence ID" value="OAS99915"/>
        <property type="gene ID" value="BDCG_01562"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01562"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="185" mass="21878" checksum="0761ED1A84289808" modified="2016-09-07" version="1">MNMDRLGWHVTRRKLFSSEFSEIFLVHIRNKICVMKVHHDNGPVQPASPERETNLHICESTAYRQLMKHGLCNRGIVPQFYGTMEQMDLSHYQPHLKMFLNDKNPPSAILLEYIPKMEMIYPHNFTKERGEALIRGIQEIHRALVLHCDAKPRNMMIVRNDPERVVWLDFDRAQTYHADSLTERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVN6</accession>
    <name>A0A179TVN6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">rRNA processing protein Pwp1, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">rRNA processing protein Pwp1, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_01582</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ER-3</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99925">
        <property type="protein sequence ID" value="OAS99925"/>
        <property type="gene ID" value="BDCG_01582"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99926">
        <property type="protein sequence ID" value="OAS99926"/>
        <property type="gene ID" value="BDCG_01582"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01582"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PTHR14091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="323"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="416"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAS99925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAS99926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="556" mass="61905" checksum="F00BD740B9FFE57C" modified="2016-09-07" version="1">MSMITATTWVRRGVAAPFPEKYEIDEEEINRISELAKLQLEGAKMDLKQAQNKNGKDEMEVEKEGEEEVEKNSAKSSGEGKGKEKTNGDGKKGDSIDDDDLKEYDLDNYDSDPVDEDGEKVTMFGNIRSLAYHQPNEEDPYLVVPEGVDDDEDDEREELQILPTDNLLLAAKVEDEVAHMEVYVYEDEADNLYVHHDVMLPAIPLCLEWLDIPVGRNSENRTYGNFVAVGTMEPDIEIWDLDIVDCMYPNAILGQGGQEESSEAGTKKKKKTTKPKKANDEYHVDSVLALAANRQHRNLLASASADQTVKLWDLNTTKCAKSYTNHTDKICALDWHPKESTVLLSGSYDRTVVAADMRTPDAKAARWRVESDVENVRWDPHDPNFFYVTTDGGMVYCHDVRQASAQPENPKAVWMLQAHDSSVSSFDINPTIPGFLVTGSTDKQVKLWNVQDNKPNMVVSRKLEVGKVFSTTFAPDQEVSFRLAVAGSKGVVQIWDTSTNAAVRRAFSARLGPSAGEEVKERMIGISQNDSDSDDSDAAEGGGEMGQDGWESMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVP5</accession>
    <name>A0A179TVP5_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C6 finger domain transcription factor nscR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Neosartiricin B biosynthesis protein R</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_00570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor that specifically regulates the neosartoricin B biosynthesis gene cluster (PubMed:23758576).</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99492">
        <property type="protein sequence ID" value="OAS99492"/>
        <property type="gene ID" value="BDCG_00570"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00570"/>
    <dbReference type="OMA" id="HQNMLFL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="Transcription_factor_dom_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="SSF57701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="723"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAS99492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="984" mass="109542" checksum="C487F01D49F593C4" modified="2016-09-07" version="1">MEDERGSTSPRSSRAQVVQLQEDATGQKQNLNQAPMNTNDLNAKREGSVSAREHGDTENPRPWSELKTKAGKERKRLPLACIACRRKKIRCSGEKPACKHCFRSRIPCVYKVTTRKAAPRTDYMAMLDKRLKRMEERVIKIIPKDEPRDMAAIGRSVVKPPTSGQIPRGYRPVHKKRSADEAFRAELNEWTQPNKGTGPDGFPICWQSQIMDENKLFNEGAEFLPSIELQEHLAEVFFDCVYGQSYLLLHKPSFMRKFKTGTVPPVLMLAICAVSARFSTHPLVCTEPAFLRGENWANPAAAIALSRHDEPNITILTVFLILGLHEFGTCHGGRSWSFGGQALRMAYALQLHRELDHDPQRSSKASELSFTDREIRRRTMWACILMDRYNSSGSQRPPIGNEKYLQIQLPIKESHFQMEIPGPTEDLEGRVLNPVPEGVGQLSNPKDNMGVSAYTIRALMLWGRAVDYFNLGGRNKDPHPLWSPKSGYAQLKKQLDDFSASLPNCLAFNLENLRNHGAGKIANQLLFLHIVTHQNILFLNRFAIPLSPGGKPPKDIPREFLSDAGRAAVEAASHISMLINQAPGYNLTVPFAGYSAYAASSVHIWGIFSKNARLEATSKENLRHTYRYLNKMKRYWGMFHYMVESTKDRYRQFADAAIKGVQFSSSEEDAPLFQYGDWFDKYPHGVSQLHYEDPPSRPQQEPGGDAVMAQQSDLQSVEEFFASLSPPSHSDNPRKEPKRRAGSITEPRQPLLNSLNPNNRYMSPQQQPHPSSQPPSQPPSQPPSEPPPQPPAQPQPQSQQVLQHPIMDVPINPTRPPDFHLNSQAMFPQAQTPNFSPSTHLSINPDQLPLLDRQLVYGAYTGHDPTVVPSTSTSTSNPLAVNHPVRMNPAPGVSMQQGLNAPSTATWNSQFDVSGNPAAWSSEFVHPGAWFLPFNLNPIGQGLADMNAAPATSGAPGLGTPPLVNTLGTYSAPNAMMGAYDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TW00</accession>
    <name>A0A179TW00_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transporter, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00046">
        <property type="protein sequence ID" value="OAT00046"/>
        <property type="gene ID" value="BDCG_01836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01836"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="468" mass="50718" checksum="4CFF21D5C2EDC5A5" modified="2016-09-07" version="1">MGKYQWQLFVLCGFGWLADNLWLQGVALTLPSLSVEFGIDESYVRFTTCSLFVGLCVGAVVWGTASDMIGRRLAFNLTLLITGVFGLASGGSPTWVGVCSMFACLGLGVGGNLPVDGALFLEFLPFASGNLLTMLSIWWPLGTLVGSMIAWGLIPNFSCDPADLLCTKENNMGWRYLVITLGALTFVMFLCRFFLFHLYESPKFLLSRGRQEEAVATVHAIAYKNGAKTWLTNEILNEIGGHPEQISPDQQKLSNSEIVRRQLSKFSAQRIAPLFATKRMGFTTVLLWFCWGTIGMGYPLFNAFLPQYLGNSGETPVSIVYRNYAITAIVGVPGSILACYTVDIPYVGRKGTMAISTALTAVTLFCFTISDDPDVQLACSCLEAFFQNIMYGVLYAYTPEVFPAPNRGTGTGIASCINRICGLLAPIVAIYGSSGNPKAPVYASGGLMLAAFVAMVLLPIETRGRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TW07</accession>
    <name>A0A179TW07_AJEDR</name>
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        <submittedName>
            <fullName evidence="12">RP/EB family microtubule-associated protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_01123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAPRE family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626723.1"/>
    <dbReference type="EnsemblFungi" id="OAS99719">
        <property type="protein sequence ID" value="OAS99719"/>
        <property type="gene ID" value="BDCG_01123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01123"/>
    <dbReference type="eggNOG" id="KOG3000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EQCGTGG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016043">
        <property type="term" value="P:cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CH-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
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        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
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        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="PTHR10623"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="11">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAS99719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="246" mass="27217" checksum="F2100BF35F39D31E" modified="2016-09-07" version="1">MGESRQELLAWLNNLLQLNITKVEQCGTGAALCQVFDSIYMDVPMARVKFNVNTEYAYLQNFKILQNVFIRHQIDRPVPVENLIKCRMQDNLEFLQWTKKHWDQYYPGGEYDALGRRKASGAPASNSTRTTSASGARRGGTTPVNSAGGRPRLAGGVGGANSAALTAEINAQKEAIAGLEKERDFYFAKLRDIELLLQQAVEADPELDKDDDSLVKHIQAILYSTEEGFEIPEAEGAAGGEELETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWQ5</accession>
    <name>A0A179TWQ5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMGC/SRPK protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00255">
        <property type="protein sequence ID" value="OAT00255"/>
        <property type="gene ID" value="BDCG_02298"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02298"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="383" mass="43382" checksum="C3A7B56C77C4C89A" modified="2016-09-07" version="1">MNFLKSLLPATRRISNSRSHISKLSEEPYQKYSSGGYHPTRLGDVFDEKYQVVRKLGYGQYSTVWLAQDINVDGMRNYELEMLRFMKNDGSTHPGKRHILSLCDDFQHHGPHGDHICLVHEATGPDLAKYQRRLPEAQIPVPTVRQIAKQLLLALDYLHRSCSIIHTDIKPGNILIEMDENEPIALRALPSDVSKSSEFYMASKPLPMNSDVSTINVFLADFGTASWVDRHLTEFIQPRCLRAPEVILEAKWDASTDIWNAGCVIYELLTGKYLFDGCPSAAGSYAPEHHLSQMVALFGHFPIDLLNRGQASEKYFDSEGNLKGIPAMSGFSLGGFIENGSFHSIQEKEDFIQFLQSMLVLAPEERKPAHLLLEESWLNKEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWQ6</accession>
    <name>A0A179TWQ6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00344">
        <property type="protein sequence ID" value="OAT00344"/>
        <property type="gene ID" value="BDCG_02503"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02503"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="294" mass="30811" checksum="A50D3C470690A565" modified="2016-09-07" version="1">MDPGQLHPPYPPPPYTSRPTTPGLEVDDFHDNTPGPSSSAAPNNTRSGAAFHPQRQYIPLQNLPSHSHNAPNNIAENEDSIPAHILAESRELAELHRMALDLTIGNGGADNGYGSPYPDFEDPDGQATHGDASSGYEDFVEPDGQPLPSAQTSIHGGGNTQDNVSVVSVGASHGPAAGVVNASAAAQATQPVIQPQPFVHSFIPSAIRPAPVQNPNYVPPYGPYPFPTVHQIYVGSPAPVLPNAGGGGANQGANNVVPAQANVAQPTNNPPATVPPSNTTYRRFNRPKRSKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWQ7</accession>
    <name>A0A179TWQ7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">MFS transporter, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_01696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ER-3</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99978">
        <property type="protein sequence ID" value="OAS99978"/>
        <property type="gene ID" value="BDCG_01696"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99979">
        <property type="protein sequence ID" value="OAS99979"/>
        <property type="gene ID" value="BDCG_01696"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01696"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAS99979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="392" mass="43180" checksum="31C5E77148B31F7F" modified="2016-09-07" version="1">MACKWIGPGWYIPAISLGFGITSVATAFVNNIHEICGVRFVLGIFEAGMLPGIAYYMSRWYRRSELTFRLSLYIVMAPLAGAFGGLLASAILKLSNFGSLHEWRMIFAIEGIITCGVSLISFVTLTDRPATAFWLTQEEKDLAIARVKSERVGATEVLDKLDTRKTLLGIFGPVTMVTAFIFLLNNITVQGLAFFAPTIVKTIYPDDSVVSQQLHTVPPYVVGGFFTVLFPFLSWKFNRRLIFFILSAPLVMIGYIMFLASDNSKVRYGATFVIASGAFSLGALSNASVSANVVSDTARSSAIGTNVMFGNIGGLISTWSFLPFDSPDYHIGNGLNLATSSTILICSIALVFWMHLDNKKRDKENVEVKLAGLSQTQIQNLDWRHPGFRWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX05</accession>
    <name>A0A179TX05_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COP9 subunit 3, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99376">
        <property type="protein sequence ID" value="OAS99376"/>
        <property type="gene ID" value="BDCG_00290"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00290"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037753">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="PTHR10758:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="442" mass="49412" checksum="C39BE0C631F401BB" modified="2016-09-07" version="1">MAEILSRLLSFPPVSPRTVSQISDVEYDKEIRTLYSDLKRIPAHKLVADIPGRGSLLELLDPGLQTLAYLFVILSYYQVSHENTKESFPATWLPGGEIWLKSVAFLKVFDPIQVRYAGQEWRSLVDVVVKSAEIASRPLLALHPLKTAILRLDPSSSTFTSSHTTFVRLCLQSRSYLNALDILDKPICHFPTTSDKQFIKRSQLLLCQQHESSTSFITAASGLPGKINHRSYLEYFLYGAMVYMGLKKWDDAIHFLEIVISAPTTNSVSIIMVEAYKKWVLVCLIEKGKPLPMPKTVTPFTAKAYRSLAKPYEALADIFKSGNVSRLLAEIAAGEAVWLNLRASLIHASDSSTPTVLRFTSSTANLGHLLEVKFSADLVTQRSRLETLLKNVRGTDIKLELGREYIESLRKAPRPSDVESRDRSTAGVSNGEMDEDVMGDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX10</accession>
    <name>A0A179TX10_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYB DNA-binding domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99992">
        <property type="protein sequence ID" value="OAS99992"/>
        <property type="gene ID" value="BDCG_01712"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01712"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="204" mass="22904" checksum="0B88461D3E668E38" modified="2016-09-07" version="1">MNEMNWPVFVSRPPLPNMSSPPTSKRIKTTVASNTPTHPLNQQQQQQPHPFTGPGPFESASMVPISTPVPAPAPAAPNPRKRREGNTTTTSITGAPTAPEPTVKKKGRTNTPWTAEEEQRLKTMRDAGNTWSEIAKTFPLRTEGSVKKHWYKDMHYAEFTEEESITLRDAIKEYESSKWKVIGQKIGKPAKACEQYAKEHFKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX14</accession>
    <name>A0A179TX14_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_02541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00355">
        <property type="protein sequence ID" value="OAT00355"/>
        <property type="gene ID" value="BDCG_02541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02541"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="38"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="257" mass="28605" checksum="F15AB085654E0102" modified="2016-09-07" version="1">MPAGNPAIQVSTMATPSLQGNERAIEYFQLGPFTVPRLFIGLWQLSSPAWGSASKSKILSQFQKHVDSGFTAFDMADHYGDAEIVFGEFRLSYSGPKSIFCATKFCVFEHITVTPDGMRDAVSQRLANIKSDKIDLLQFHWHDYNDAQYIRALQLLQNDERVAVLGLCNFDTKRMEEVIGAGVKIATNQVQFSLIDTRPKYAMAEVCEKHNIKLLTYGTLCGGFLSEKWIGKDEPDAFGAGMTPSLRKLNTQSSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX18</accession>
    <name>A0A179TX18_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activating protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_02845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00454">
        <property type="protein sequence ID" value="OAT00454"/>
        <property type="gene ID" value="BDCG_02845"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02845"/>
    <dbReference type="OMA" id="GIHRQVR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GTPase-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GTPase_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="SSF47923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="218"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="541" mass="61067" checksum="D612CE5927F7C770" modified="2016-09-07" version="1">MVRTTSPYTRQHVSPMSPRTSSNNRSSSSTHLTEPGGIAPPNRQPYASLMAQPGEDWSHDDDGYEDELFYDDDEDEFGLPSVTSMRKKGASRYKLQTAGGDARGGSKSRINGSSTLNPNLPSARLRTNSSDIAEERGILSYPTAKKTDGKILRPQYKELLTDPANSLHLINHSPPPPNGTPKELEVHSSRISRINKFKRILQSSTVSLPELRDLAWSGVPDEVRAMTWQLLLGYLPTNSERRVVALERKRKEYLDGVRQAFERGNSTVDKPSGAVSTSNGGTGRGLDEAIWHQISIDIPRTNPHIPLYGYEATQRSLERILYVWAIRHPASGYVQGINDLVTPFWQVFLGTYITDLNIEEGMDPGQLPKTVLDAVEADSFWCLTKLLDGIQDNYIYAQPGIHRQVGALRDLTMRIDSTLAKHLEQEGVEFMQFSFRWMNCLLMREVSIQNTIRMWDTYMAEEQGFSRFHLYVCAAFLVKWSDQLLKMDFQEIMMFLQALPTKDWTEKDIELLLSEAFIWQSLFQDSSAHLRTSTGTPSGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX23</accession>
    <name>A0A179TX23_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal specific transcription factor, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99396">
        <property type="protein sequence ID" value="OAS99396"/>
        <property type="gene ID" value="BDCG_00348"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00348"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="Transcription_factor_dom_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal_trans" evidence="2">
        <location>
            <begin position="263"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="659" mass="73859" checksum="A4F60CAEFF985219" modified="2016-09-07" version="1">MKEHIETLQDQVNTLFANINELYQKTDSSAVESNAYGRELSRSLSQPSYDSQNQTPPRPRSNHPRFHGPTSTTFNLHVAKSSLQTMGITPAEDGNHDLFAGQDATPVDSPPPQQQQLPPIPQLSAHPNKDPLWVIKREEAIRLCRVYEREIGIMYPLLDIERLITHTNLLFTFLEAASRTGFTRRFKPGPDMLTDDDTCILKMVLAITLIVEGNGQSALGIRLFTTTKQRIEMKLWEPTDLRTIQLFALMATYHFHTDEDNMAYRFIGHTTRMCLELGLHRRDGMFKVCPNEADIPSVAKLFWSVYCLDRRWSFGMGLPFIIQDEDIDSSLPEPDDSVPYLKAMISYCRIGSKIWYSGLGSVGTVTAKREVIGFLDYQVLQWLKNVPENLRFYSPEHSLNGDGIDRETRRLRVLLYIRGNHMRILIYRPVLHSTSGILENMGYAETVVDIAKDTIRVLAHLNQTSDIYRSHQMLFNYFLVSALAVLLLAVSHAPAEFNRQVRDEFYMALDLVKGFSAKSYVSKRLWKMIKGLRGIGEKLGLLNRPAPPDPNDPHSTAAVAMAGLAGHPMDVMAVYRDISASGELGNSPQDGVQMSNELTHLFEAVGGYGGFLAQTNSAGDGDGINGEMVNAQGDLTSAEGLGSILGNEAEFARIMRDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX30</accession>
    <name>A0A179TX30_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein, variant 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DJ-1/PfpI family protein, variant 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_02731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ER-3</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002624015.1"/>
    <dbReference type="EnsemblFungi" id="OAT00415">
        <property type="protein sequence ID" value="OAT00415"/>
        <property type="gene ID" value="BDCG_02731"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00416">
        <property type="protein sequence ID" value="OAT00416"/>
        <property type="gene ID" value="BDCG_02731"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02731"/>
    <dbReference type="eggNOG" id="ENOG502S3AM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="249" mass="27222" checksum="43AACC22CD91AE3A" modified="2016-09-07" version="1">MAANASAPVHYAVLLFPGFQALDAFGPLDILNIVALEQEIQLSIIGPTMDPVSTKSPIPNFYTTTSTSHQSVVPTHTYDAPPENIDVMIVPGGFGTRHETIKPTVQFLIERYPRIRYLLTVCTGSYVAAQAGILDGKKATTNKIRFDLVAAKAPHVNWVRQARWVVDGNIWTSSGVSAGMDEMLAFVQEVYGRKLAVKVATILEYNWHEDSTTDPFANSPLVEMYGAGAADWYDFRAATAIGKDRASSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX34</accession>
    <name>A0A179TX34_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AT DNA binding protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
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        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99618">
        <property type="protein sequence ID" value="OAS99618"/>
        <property type="gene ID" value="BDCG_00910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00910"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="527"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119035" checksum="F7FD737C6A2A0DD9" modified="2016-09-07" version="1">MDYRSDTSSPDPLGYPGDPEYILSSATKPFLRRQSTFSPRKSLSPTRRLSPSKADGRSAQSIRFQDIILPSTPSGRFSGKHRLSPTKTTTLNSENNTSPWRIRVTVEAEQDEADENFPGSVRSGMKSRRGRTTKVPLKDENDSLEPSPKKRRTGKSDLSQRVPTPRKIRSRIETPTGNTGTAEKRKRGRPRKSQPSVEGSNVVNKATFAESVRKKMREEDPFLDIATEDSGTNNTAVDNILADTADPNPLPDFILSTSDHRSSPTPTERTMSQQPDSRSRVEGSAPDNPASFMSSPYSPGKPTGLTPENTIDAGHTPGPQVRGYPTPTSSSLLEEGIAEIQTGDSSGAKNQQSGSVLDPTTQHREFDSILESEGFSMVSLGTLPSARQQLNHSFQDAVNQGMINSMKKSPKKEVLGKSKSESRHGGLSVSSIPKKDDAYMPSSEPQQTSQLSQQVRRSPRRNNKTPGTIFPSSQQPRAPAIQPSRPPKKTRLVKLVRVIRAGIALQGVLNRRRRNSRLQSPFSSPGQTRGDDREAVRQRLDALFRGFGSETERELRAGLRFGEQLANRLQESESRKKREEPGPAVDSPMTPDGFAANERNDAGYAGIGNAESRSASSHSVKKHSNRELDGKSQLMSSLGNKNQSPQLRLGSEMARREAQWQREREIISRQIQQANSSQVIVIDSDEGSPERRPLGNEEPEEHHEDNPMEEEDYEDIWQQEARDVESQSESASFVELSREEIIKPPRRVLPSPWKRNVDVADHSQDEEATPGPGPYWANRTNLYPLLPRGKTETAKFREQNVESSSLLGSPESATRRFYQQNNVSPENASSQPEYPEDQRPMRSTTIPTFAASYGRNESPYSDDQVSDADAIHPQWAPSPESGKNETRQTSPDNGDVYSQPSVEDDHLYPELPSNSVHSSRNRPGAEEEIYSETESPNLTPLALQYYQHDKEPSTIQSQSPTEPQQEPRPSSWFHKLTDLAPSWLTTAASRKVERKQPESISNPASPSSPNREPSVESSSIQMSPPTQRYSVSGSPAQPLPIESSPIQQSPSISALINPSRGRWSTPEPSSPRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX37</accession>
    <name>A0A179TX37_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00425">
        <property type="protein sequence ID" value="OAT00425"/>
        <property type="gene ID" value="BDCG_02772"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00426">
        <property type="protein sequence ID" value="OAT00426"/>
        <property type="gene ID" value="BDCG_02772"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02772"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="318" mass="35167" checksum="51B0E6E217CCE7DF" modified="2016-09-07" version="1">MTATVDSSSTPQSFTGVPNSEIRYSGFSSRQEQYTTEHMNTFHYNMPSHSSAFAQPSYHYAGPGHTHLPAYGIEPESASSLEFPTNFTHRNPPPQASIPSDGLINMPPPGGYHYSVPQSQVSSTRQYKDRISITLSEHHAPDQESRPSNSRDEYIQHGFTSHPATEPYSDLSTNMASLTPDYLNHPVPNVTGHAYPASPSLYEPLHPYQRQYSFSPIPDTGVPATSASADNFSTPYSVSPAPEDQVRIVNSRPKPQCWDHGCNGREFSTFSNLLRHQREKAGTATKSECPHCGTVFTRTTARNGHLAQGKCKAKREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXQ3</accession>
    <name>A0A179TXQ3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_16534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
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            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="108" mass="12462" checksum="08B62AA71CEAB7D5" modified="2016-09-07" version="1">MGQIGKGGTRVRLGVGVLEHQRWTGFSRRSLLGYLHNYRSGVFQNREDWCIWLGHFTLQFGMRSAMGSKCSYDRGLFDGSIGGFLFEKSSEFVVERLVNNFHHFLNRL</sequence>
</entry>
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        <lineage>
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            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
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            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OAS99838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99837">
        <property type="protein sequence ID" value="OAS99837"/>
        <property type="gene ID" value="BDCG_01377"/>
    </dbReference>
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        <property type="gene ID" value="BDCG_01377"/>
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    <dbReference type="OMA" id="EFKARTA"/>
    <dbReference type="Proteomes" id="UP000002039">
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXS2</accession>
    <name>A0A179TXS2_AJEDR</name>
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    </protein>
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    <organism evidence="1 2">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
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                <person name="Whiston E.A."/>
                <person name="Young S."/>
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            <dbReference type="PubMed" id="26439490"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00956"/>
    <dbReference type="Proteomes" id="UP000002039">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="164" mass="18905" checksum="BC97AC7619A9A48C" modified="2016-09-07" version="1">MHKPGSHAWQGPESSFAFILPSFVHQPYRATRNGCLQMDPDGVIGALLININKVETSSFWAARRETDPHDPSHTLDVTHSTCGQIHQHREVTARHLQIAPKLHRWMDSWLPLLLLGPDYSQYHALPFTLCFYPSVSRVKLLRKEHGNEILYEKRGSYPKMNKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        <lineage>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
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                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
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            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
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    <comment type="subcellular location">
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="645" mass="70727" checksum="964F738755276C26" modified="2016-09-07" version="1">MSNFDSLYERSLYLSPDQQDLLLAALSSGDKSSKMTKPDHRHNPQSDFNLQDSRPNTSSPQDNSFDNTGVSNQDLFESPPEEPLDLGQLGFDGSPFLGFDLDVDFDPNEDLIGDLPGPSPNGEDNEQREKRKSIDGNEEEESGKKRKETDDKTAKKPGRKPLTSEPTTKRKAQNRAAQRAFRERKEKHLKDLETKVEELEKTSKLTNNENELLRAQVEKLQVEVKVYRKRLSWINSGTSLLPSTSSGMRGSEYRNGSHHSGNDFSFEFPKFGDLPSSHTFSQSLSKAPSHHTKHLTASPTTTGVDYKSPNKSSGNFFKSAHLAPQQQTFNPGNTPHSVPTPDSMNSSGTPSSQGRNSQSASIENLNGFDTYSGRPSRNNTGLSYTSTGSGANSNTNNYLTYQTQHYGSSNASNSASPSASSESHHLSSIGTSPEPSVNSPPTGKLTESSLNTINELNASHAGGEDHNNNISNSSSNNHGNINYLADGLLGIDWLAQQNGGQFDPVLFGDYRDPQDAVLSQDFGNFFNDALPFPEFGSSLQTFNELNNGHANTTASTTAPPKHDLLRQVDSILEGNHDEEVVPAEDRSQMLSCTKIWDRLQSMEKFRNGEIDVDSLCSELRTKARCSEGGVVVKHDDVEAIMSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXS6</accession>
    <name>A0A179TXS6_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_01439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99858">
        <property type="protein sequence ID" value="OAS99858"/>
        <property type="gene ID" value="BDCG_01439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01439"/>
    <dbReference type="OMA" id="EEHEIRY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037979">
        <property type="entry name" value="PPP1CA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF377">
        <property type="entry name" value="PTHR11668:SF377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="8">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAS99858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="308" mass="35561" checksum="502BE2C02C4456D3" modified="2016-09-07" version="1">MADLNEIDLDSIIDRLLEVRGSRPGKQVQLLESEIRHLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDCGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAEKKQKFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXT0</accession>
    <name>A0A179TXT0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00358">
        <property type="protein sequence ID" value="OAT00358"/>
        <property type="gene ID" value="BDCG_02547"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00359">
        <property type="protein sequence ID" value="OAT00359"/>
        <property type="gene ID" value="BDCG_02547"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00360">
        <property type="protein sequence ID" value="OAT00360"/>
        <property type="gene ID" value="BDCG_02547"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02547"/>
    <dbReference type="OMA" id="ERAYANS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="228" mass="25253" checksum="667C2EC47B10B179" modified="2016-09-07" version="1">MIVENNEDTDSESSSSSMSAPSTAPTLSRPSSSAASDSFSESIDTNNAGKLPARYALEEDADGNLTTPPEANGAGIGHYCFFHILDCDKSFTNLDLWKTHVLSHFRLHPAPTTAQCPACPYRISDPHHGIAWRRMLTHLADQHLKQGYSIQNICPDFETMRHLYCANIITRGQLRLLQLPAAPGRPGYSPSLDSVRVGIGSSDDPCVVYMNRHRERRMRERSRKISVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXT1</accession>
    <name>A0A179TXT1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_02310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00263">
        <property type="protein sequence ID" value="OAT00263"/>
        <property type="gene ID" value="BDCG_02310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02310"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="PTHR43137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT00263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="280" mass="30604" checksum="115ACEC8B5497BB4" modified="2016-09-07" version="1">MSLYLHPSITPETIIEAKRNGVIGVKSYPAGVTTNSDAGVIDYEAFFPVFAEMEHQNLILNLHGECPSHGDITVMSAEERFLPTLLDLHARFPRLRIVVEHLSTAAAVETVKKCGPSVVGTITAHHLSLIVDNALGDPFCFCKPVAKLVEDRDALLRAATSGSKKFFFGSDSAPHPTGSKRGGDKIAAGVFTQPYATQYVLDAFEKGCESGVLKAEDITKEVLEGFMGKFGREFYEVPQEQKEFITLSKAKGKILDVLKSEKTDVVPFRKGEVTWGLTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXT2</accession>
    <name>A0A179TXT2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00625">
        <property type="protein sequence ID" value="OAT00625"/>
        <property type="gene ID" value="BDCG_03224"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03224"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="134" mass="14959" checksum="CAA2AE92F17C3C9E" modified="2016-09-07" version="1">MTKKTSYHLVHESALINCQSRLNKMELRQPVDGGLFLCRLALLAVGVLGIFMARKRVGNHANVTYRWLLGILKMATGFCCARPHLTKQIDLKTLPYAVTAPSPVDIGNWAVNVVNNQSSSRHPSWADMQMTCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXT3</accession>
    <name>A0A179TXT3_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit Tim10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_01410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99847">
        <property type="protein sequence ID" value="OAS99847"/>
        <property type="gene ID" value="BDCG_01410"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01410"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space protein transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027100">
        <property type="entry name" value="Tim10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="PTHR11038:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="SSF144122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="zf-Tim10_DDP" evidence="11">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAS99847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="79" mass="8799" checksum="16C61A1C86843A96" modified="2016-09-07" version="1">MDENLPPPLRKKKEPNLSSACMKKCIPPDYREGDLNKGESVCLDRCVAKFFEVNMKVSEKMQQMQGQAMGQQGGSGFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY24</accession>
    <name>A0A179TY24_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="3">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BDCG_03639</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = H(+) + NADH + uridine(47) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = H(+) + NADPH + uridine(47) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="3"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00814">
        <property type="protein sequence ID" value="OAT00814"/>
        <property type="gene ID" value="BDCG_03639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03639"/>
    <dbReference type="OMA" id="FRTCAQE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dus" evidence="18">
        <location>
            <begin position="104"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAT00814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="395" mass="42908" checksum="9A795D8257E96DAD" modified="2016-09-07" version="1">MFKRFLQLIMGSIAKSPHPVPALTPRVPIPKNGVDYRGKIVLAPMVRSGELPSRLLALKYGADLVWGPETIDRALIGCTRRINPRNSMVEFTRLPSNGGRQNTPNAKESVIYRIDPHRESGKLIFQIGTASPNLAVQAAKIIAADVAGIDVNAGCPKPFSTSGGMGAALLQTPDLLVSILTALVQQIGNPYQIGISVKIRLLADPERTRDLVTRLCATGITGLTVHCRTTPMRPRERAIRAQLPMIASICRAAGVAILMNGDVESRDHGLALMSEYGVDGAMIATSAEANSSCFRSGAQGGLLPWRDIVYAYMDFCLQCENKWGNTKYLLNMLIPGKERAFNAAKQSKSYQEGCRVLGFEDLIARAKEVDAIIGRTPLDAYADAEEQGESCKRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY40</accession>
    <name>A0A179TY40_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_03585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00786">
        <property type="protein sequence ID" value="OAT00786"/>
        <property type="gene ID" value="BDCG_03585"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03585"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="370" mass="41022" checksum="F91AADDC94B4C5A4" modified="2016-09-07" version="1">MHLITQIHKTLLPHAVFDLHFSPRDQSQFAIATSAASVSLYRLEYSSPKAPSSIVHLTTIPVHEDPSIPALYLSWLPPPPLLAGDKRVKHSHGRDHSPSQLSTDGFAVSFSDGRVSIFHTNPPSHDFSKESMTEIVLPGEPIEVWFTTFHYGRSLSGEEHLTLFSGDDFGGLRVHEFAGDGDEGSRMLWDDGQFPAQTMEVTVGRKHYGAGVTAILPLFTEGGETVLLTGSYDEYLRVYKFTGRGSVLAEERLGGGVWRLKIIREVEDEILALEWPSRTGRSRSYLVLASCMHAGGRIVRVTCSLGSEGDAPRVGSWSIETLAQFTEHESMNYASDIWRGREEGETQGDPLLCVSSSFYDKRVCIWKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY49</accession>
    <name>A0A179TY49_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_16760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00796">
        <property type="protein sequence ID" value="OAT00796"/>
        <property type="gene ID" value="BDCG_16760"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16760"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="348" mass="38682" checksum="01C34CCC64841AF7" modified="2016-09-07" version="1">MGSGLNANFTPNPTTEAHSHWNEFIHGSRYQDVFELSYGGHHSNNSDLPQPDGSLLPLDAHDFGVEQNLMTPNDGSFSTMPQMSPDSWRAPSNPISSPMAEWSNYTARRSQMSPDSWRAPFNPMSLPMSELADHTDCRSQMSPDSWRAPSNPISSPMAESSNYTGNAMNSFSQTELPLYPYSNMIEPGNQTILPRQRTQAGHPHGAGLDRDCSTPCRTGNIDPSKPRGIWKQKTSSRKGFSNNLPSNHFQPPLPKTGPQSQQVTGPFIEYAFHACSGEPATAGAKKRRRTKMEKRETAQIRKLGGACGACRRKHRRCSVEHHQRTDRLSAQSAISNYLISISWWNNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY57</accession>
    <name>A0A179TY57_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Laccase 3, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_02630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A179TY57"/>
    <dbReference type="EnsemblFungi" id="OAT00393">
        <property type="protein sequence ID" value="OAT00393"/>
        <property type="gene ID" value="BDCG_02630"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02630"/>
    <dbReference type="OMA" id="MIIDGPA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107137" evidence="5">
        <location>
            <begin position="30"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="88"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="214"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="424"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT00393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="587" mass="65870" checksum="5D7A3F06A6C03B24" modified="2016-09-07" version="1">MTSRRNTSLDLSIIIYFLWILLGSSICAAQSNTYHPISAKGPPGFVSDKHCKNSPKNRACWGGGFDITTNFGTKWPETGKVVEYLLEVSNITLAPDGVERLVLAINGQFPGPTIRANWGDTLRIHVKNNLQNNGTSIHWHGIRQQHTGHQDGTNGVTECPIAPGASKTYEFKCTQYGTSWYHSHHTVQYGDGVLGAIEISGPASANYDIDLGTMPIQDWYYRTAWENALLGIPPVAENGLINGTMVNANGGGKYHENTIQKGKSYRLRLINTSVDNYFKVHLDNHLFTVISSDFVAILPYQTDWLFLGIGQRYDVIIHADQEIDNYWFRAEVQRGCGENAMNGRIKSIFRYKGAEPNAEPTSVASNYTQSCDDEQGLVPFVPIDVPSEHFIQEVKDLNVTFEPEVTSPGQNIVHWKINGIPIETDWEYPTLQYVLDRNTSFAPKLNVIELPEANWTYWIIQAIPGSIVNVPHPIHLHGHDFSVLGTGRGDFPGPERLNFTNPPRRDTVMLPDRGWVAIAFPTDNPGAWLAHCHIAWHAHEGLAVQFVERYSDIAKALDIPHTWHKTCEQWTDYIVNDAIYQQERSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYS1</accession>
    <name>A0A179TYS1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00188">
        <property type="protein sequence ID" value="OAT00188"/>
        <property type="gene ID" value="BDCG_02101"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02101"/>
    <dbReference type="OMA" id="DQRISTC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="216" mass="24867" checksum="8A4E7FC45E638D38" modified="2016-09-07" version="1">MQFIAANTTIPVPKIYNTKFDKEKHISYIVMEYIDGEPLNKAWINLTQDQKVSTCNQLVDYLTQLQMLTGERIEAVNSSTVRVGLYESRWGGPFDSEKEFNDFLAQGLQQHNLTDNHAIHFAHGNLSPRNIMVNKCGRITAILDWEWAGWFPQYWDVVRMLVDIPGKRQMPDYAEHLRATLPYLYKEEYSAMLDVFRGRSSGPHGGMPAHATSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYS8</accession>
    <name>A0A179TYS8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00603">
        <property type="protein sequence ID" value="OAT00603"/>
        <property type="gene ID" value="BDCG_03149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03149"/>
    <dbReference type="OMA" id="EDPYEHG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="321" mass="36391" checksum="3E5341AC6CA135C8" modified="2016-09-07" version="1">MGPERLLDDLFWVSEGANCYVYEVNPLVVVKVPKAGAQEREQFRKEVEIFNVLSRHPPCPYVISCFLHTNDCIFLEYMRDICLSWRIQQNHIRDHETMRVVSVEKFEPLYLRKTWMNDLSHGVAFLESLNLAHGDLRPENILLDRNRLKLSDFDSTTDIGSQFEACIAPYGRLLGSEGGPRQGTAGLLGPRTEQFALGSLFYLINYGFEVYGDQCFGDDPSGKEHGPVVMDLLQNMIFPELNREAMIDSIIRRCWYGEYETVAELAADTEKLCGMGSEASRGKIEGVKCSAPLSADDFSSRRKLCEDLVRCGIPKADKQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYT7</accession>
    <name>A0A179TYT7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretory pathway protein Ssp120, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT00985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00985">
        <property type="protein sequence ID" value="OAT00985"/>
        <property type="gene ID" value="BDCG_04021"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04021"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="PTHR19237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="165" mass="19234" checksum="03DFD96C3AEAF11E" modified="2016-09-07" version="1">MIEEHHISNFDPGSFFMLHDYDDSGVWTVDEVRRTYGLDDKSNAHLAEERKQQILKEIFSIFDPQKTGVISQHEWMRLSREGKRLPDFGTGPGHHGDLEYEYEIHHFEKYHGDGATEEDLTHPEDIEHFRQHDHAEDAQIRLANLQKMVIVETNIPAKFLKSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYT8</accession>
    <name>A0A179TYT8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_00123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99301">
        <property type="protein sequence ID" value="OAS99301"/>
        <property type="gene ID" value="BDCG_00123"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00123"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAS99301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="673" mass="77413" checksum="5FC5077D8CB22D66" modified="2016-09-07" version="1">MPHVNDFPNPSQGWSSYVYEYHFSFYFVTLDYFEPDTVKPDPRKIRRSCSFGKRKGTKHRYIHEETVSFLLCGHFDDAFTCYQLGDTYFKPRYTKDTGPRFFRSYDPSQSPGQLLLHWIAVALFHARSRWENAIDSLQSEIRAPSDVVFMEDRSDLMADDPQFSLSKTYFWALQTYKLFERTLEQTITTWETFKIDSLPKIQDGRISPENWDASVSSIDQSIELLKPKIDRIKRGMQDVRDLRESLQSTAAVFDSRTAVRQGENIRLLTYITLLFLPLSFGTGIFSMQLIEPSATTINAFAITLPVITIVSALLIFNLNSLTAAFDSVVRKATFGLQRQMRLHHRKEWKHRALALHQDDISTEPPVRKASKESSHWVYILFLIETAVVVTPVSELNAALNCYGLFGFEGEKAGEGEDDEYSDNEDASTHQPRKDRQKEVLMRVKRAAREAEEQERKRKDEESGMAIGLLRRFYRYIGHLGRVLGHTVLTSFRILLLPIWVVLLLVEYILTVLTLTLLFDQPPYQANPSSATHGEESPESHPSSPFARAWHALGLNTLTLPTRHHHPHDLSYCPRLLETQSHEHALSRIQSEEQAPRLIKLPALQRPAPAITNNERREARHTAKRRGEHSPERTLDRISNVEVSVFDPARSRRTARSRISRAVNAARYEAGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYV0</accession>
    <name>A0A179TYV0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 type zinc finger domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_02220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00218">
        <property type="protein sequence ID" value="OAT00218"/>
        <property type="gene ID" value="BDCG_02220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02220"/>
    <dbReference type="OMA" id="NENHGVM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="PTHR21354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="272" mass="30575" checksum="09643C81FB5392A4" modified="2016-09-07" version="1">MGPQTSPPGKQVHLDDQNGDQEVMRCSLPPHREHISFSTYEDYEVHYAQAHSNRCLECGKNFPTTHFLTLHIEELHDPLIASRMERGEKTFSCFVEGCDRKCSTSQKRRLHLIDKHQFPRFYNFSIVVTGIDQYNSMLRGGMAPTHRRRVSVPNATQHENRLRRRKLSQSTGGENPSNVAPLPDHSSINDDTTIRTNLGNPAGSIQLPMHMKSAPSRTVAATTMGKSNSNGNSNDKGPDIAELEKSMSALRFVPTSVALRMDGKKQRQKQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYV2</accession>
    <name>A0A179TYV2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01084">
        <property type="protein sequence ID" value="OAT01084"/>
        <property type="gene ID" value="BDCG_04246"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04246"/>
    <dbReference type="OMA" id="LLIRECC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="PTHR33119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="523" mass="59545" checksum="80A0AF0D1918321C" modified="2016-09-07" version="1">MLTGNYGFSESMAKWVIDELRYKTRIYHEYGLVDVFNGGVVKSDTAVPGSIDQELRNGVSKLEDVPENLKDYHPSTNEQILNLVNPSLFPLVYGRTRILGEKLLGLGDCIASCGLGETLPVPRDKYTVFDEKLDNHSGWAGNFWKDKIYSQKFQWLPCNVEFLDKKGSYLPLDPKDPSKVAAASLAPPCRITSYINNLHPHKHRDLYETIEKVISRAIPLWNRTLSSLSAEYTRRINYDICVRESSLSPPREGENGSRKQKRSVTKSGYVLPEPRKFEPTMTPSLSPGSVDLKKQYRKSGFQVIVKLANIHLTPEKPKYNGGVWHVEGQLNEHICATALYHYDNHNITNGHIAFRQQCATNQKIKNSRGEDPDFLPEIFGKHTLSSATQIPGSVECSQGRLLTFPNTLQHRLEPFELADKSKPGHRKVLTLFLVDPHIRIISTANVPPQRRDWWTEHIESTGALKKLPKELVDMILGSGNKADFPFSMEEAKRLRVELMAERTARVTEQDRHFRHREFSLCEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ50</accession>
    <name>A0A179TZ50_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00820">
        <property type="protein sequence ID" value="OAT00820"/>
        <property type="gene ID" value="BDCG_03664"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03664"/>
    <dbReference type="eggNOG" id="ENOG502T2FU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NINSTWE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="497" mass="56862" checksum="FAC20D510701B01A" modified="2016-09-07" version="1">MFENSKPKSKSELPPLMLPIERSQKEIRREKNRLAQRRHREAKRKCASKTHTHDNIHPNQTETSASSRERQQPQSPAHNEVDPMKLDFFEEIESISDRLGPELMEKEMVDDLINIDSSWEPRFFQETSMQSRVSHTTSETAKIPDPLLDTMGDDHAEPAMRDIHRRRRNSGCSSTFGLAMLNTQPNPPLIPVHSLDKGQPSLFSDRCHSQQPGFQLAAADTSPLPDLKGGIFQSEDTETLEEHQFPTEIYRSDDLDKSLQSFSQEMMARVGEASGIRRNSCRNKRRRTSYETSERRLERILSVIEEEGYESLDDVVAEYYVGQFPKDSLLASEQFHSRTRRLGRFLHQVHRSSRAWSKREAAGYHDVVTRAAEELFQEEVRSRANVIMEVPIHPHRRASPSPSSINNRLWMPPHKEPDIPGSTANPSRNDTRASAHTVVRDLLFENGLTPVLMQDLSRLQSTVPETFTLLTELARASGLRRPDQSISVCLFLQMLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ56</accession>
    <name>A0A179TZ56_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase methylesterase 1</fullName>
            <ecNumber evidence="3">3.1.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_01549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.89" evidence="3"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002624624.1"/>
    <dbReference type="EnsemblFungi" id="OAS99910">
        <property type="protein sequence ID" value="OAS99910"/>
        <property type="gene ID" value="BDCG_01549"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01549"/>
    <dbReference type="eggNOG" id="KOG2564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHIRSRT"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PTHR14189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="125"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAS99910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="440" mass="47715" checksum="1CCD819D4343E2F0" modified="2016-09-07" version="1">MSDLQKNFAKSRLTRLPPEVLVFDGLGEDRENDHDGSTTSIHHERQDDDSSSASSVSSTGTVIPSASQNLFARPPRSASARSEATPLPWIDFFDQELFLEEDIEGLHISHHAYISAPSESGPLFVTHHGAGSSGLSFAACAAEIKKILPTAGVLSLDARNHGSTSVRRKSQGAEDNSQVEIDLSLETLSRDLLFVIDQTRIKMNWESLPDVVFVGHSLGGAVVTEAAKKGELGSKLLAYAVLDVVEGSAMDGLQSMETYLSTRPSSFPSLASGISWYTRSRTIRNTLSARVSVPSLLREDPSDTSRPWKWRTDLAATKPFWENWFIGLSKKFLQARGGKLLLLAGTDRLDKELMIGQMQGKYQLQVFPESGHFIQEDQPAKTAQILVDFYKRNDRSALVLPPKVGDVLAAQAMAKGVGAGGHGGMGADSHQATGQSQTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ59</accession>
    <name>A0A179TZ59_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00733">
        <property type="protein sequence ID" value="OAT00733"/>
        <property type="gene ID" value="BDCG_03476"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03476"/>
    <dbReference type="OMA" id="TERYIRC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="701" mass="79633" checksum="086AFC0306440832" modified="2016-09-07" version="1">MDSRYEDEGPGPQLSVELLRSIWTTQQNDDDDASSNRENIPANSAIGKRKRQDSEVLRDPSPPLVENNAKPLSPFKSVKLKRPQRAKRVASETARNNRGRKDTYVIPDTPKPLKRFTRNVGRHSIPKTGTFNDFDSELDKEGDSRAAYRSNRAGPNVTNLRDDEKVSASGEWSDSWSEEEESADEDQHDENYRSEEEVKEYTGNRGLKQTEYAEPPPSLSTPRRSSRLRVLRSHPSYGLFRSHRRSEQAFSSPKSAGSKRPLTRLMKKMLDSVEAGEPPHSSPPPQSRAAESENGDGSDVSSAGEDPTHEDSQQAGNRAVISPPESPENNACEEGGDVDTENEHRIAPHSASEHDVQIRTGSENNESDHEVQSEHESVSDICDFEDGSEMESESGETDVEEVPMQDPDDVDFWSAAALFGQHTNWSDLFAEVKKLIPSPNLTQRSPLLRKPLAAITQAKQLYARTREIRQDYQTVPDYLCEAEKSNAQKVVEQIYHILSNRVRLVFDEKGNLVSDNRELKRKRQAVLEIAVYAVPGVLTQLLQSFSLLCERIQPKFFRPYIHFGDTLQQIRVVKWVGPRRSMQYKRPHRQEVTLPPTDDEQDDHVSIISIDENSSNEQLPEGPDEFPWTTAESEALVTGLERYQGLDRYTMIRRDFRTELSGRTMEDLRVKAREIRDSYVAAVRLDNLTMDPRQWGWLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ61</accession>
    <name>A0A179TZ61_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01176">
        <property type="protein sequence ID" value="OAT01176"/>
        <property type="gene ID" value="BDCG_04494"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04494"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="367" mass="39430" checksum="D6F8D2339F90FE16" modified="2016-09-07" version="1">MEPTKSIVIIGASWAGVKTAHAILKSIPDVRVILVNPSSKHFFNIAAPRILAKPEAFNPDQYIHSIPELFQEYDTKLVSFVQGAARSIDVDGKTVTVAATGSEDMEPEDLVISFDYLVIASGSTTSATMGQDSILAPFKTTGSDDIQSTIEQTQKTIAEAKSIIIGGAGAAGVEFTGELGEAFQDKKDKSITLLTQTDRILPDLKPAVSRKANDILSNLGVNVRTSAIVTSASQDSSSKKWAITLGSGETLTADAYIATTGVIPNSDFVPTDLKTGEGWVPVDAEFRVQKKDGKHVPILVGNLKADIEKSEGKRPQYSTSDKVLMLVPIGARTGTGQLWFFVVWGWLVALLKGRDYFLSRANAELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ64</accession>
    <name>A0A179TZ64_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gamma-taxilin, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_03692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002627199.1"/>
    <dbReference type="EnsemblFungi" id="OAT00840">
        <property type="protein sequence ID" value="OAT00840"/>
        <property type="gene ID" value="BDCG_03692"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03692"/>
    <dbReference type="eggNOG" id="KOG1850">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIYPRIA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="PTHR16127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="331"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="493" mass="56686" checksum="B2863BC6E190272A" modified="2016-09-07" version="1">MAAAAPHVHPGYNSSGASHSASSHTNHSNFVNRHSDSPVSSTHSGSPHLAMAPTTMAKKAKGKKPADPSETSKLLAAKISQLEQDAAGEKDQEAEIEREVKKATRDLNQLLNNIESPMTRLETVHKKYTELLADMKKLDRDYAKSKKRADQLQKDQDKGKSELSKTATMKDKLEKLCRELTKENKKVKDENKRLEEIEKKARGVVNARLDSLLFDIQDFVTARGDARGEKADIDLDDALRAKIKTIGEKFEAREQHYKALLRSKDAEIQSLTAKYEEQRRGAESEAQRCRALSSQVSTFSQTEAELRSQLNIYVEKFKQVEDTLNNSNELFLTFRKEMEEMAKKTKRLEKENMTLTRKHEQTNRNILEMAEERTRNNDELEKWRKKSNNLEALCRRMQEQGRGQALSGELDAVDDEGTESEYDDEYEDEEEDEDLSDEGEFDDHHHHHHHHHHAEHQHPPANRAPDGIKEDEKQNKTKKRKKKKDEKHRKTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ66</accession>
    <name>A0A179TZ66_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_02438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Endoplasmic reticulum membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00328">
        <property type="protein sequence ID" value="OAT00328"/>
        <property type="gene ID" value="BDCG_02438"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02438"/>
    <dbReference type="eggNOG" id="ENOG502SA83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="9">
        <location>
            <begin position="38"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT00328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="336" mass="37236" checksum="3B857A83E8500A48" modified="2016-09-07" version="1">MYSDKDVFHHIGSTRVKTNGTTDATATGQPLTHYHSRIYSLLSWERPRTTAVSFATIVSLIIAARYLPLLRWLFKFSYLSLGFTISLEVAGKVMFSRGLASSSRPRKYYTIPKDTVESILEDLEQLMDFFLIEFQRILFAENLTYTLAAFTAALTSYWLVRFLPLWGLALILVSVAYLGPLVYINNREIIDTQIDQIQQIVNSQATQVKEMAGQQTAHATHIVKQYVGDYTAKANEYMGSARSLPHVEQVAPTTVQAQPELRSAAEPAVEPLTEPAAVASDAEPVASELAATEPTDAVPAIVHTDFPTAPKDDIVLGEVPARESREETKSDEPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ79</accession>
    <name>A0A179TZ79_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01224">
        <property type="protein sequence ID" value="OAT01224"/>
        <property type="gene ID" value="BDCG_04620"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04620"/>
    <dbReference type="OMA" id="NEGWENS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="337" mass="38916" checksum="31EA805210C4DBA3" modified="2016-09-07" version="1">MSHLLARKKSTSSLHRKQLEASSVISSTTPSDQMPREEKSAPYENAHYRMLLQTKGSFMKESKLGITDASKSSYQTLLDAEQRVPENSLFHDNLFEKTCEKMQDRNEAMVIQDITRLIVPSAENLAIYGNEHLKFLIESVSEGWNNAIPVTKPRPQPDYSVGFRREAFTDDQLQRLQPFVGDLTDTSYFMATFYMYFPFLTCEVKCGAAALDIADRQNAHSATIAVRATIELFKLVKREREVNREILAFSVSHDHTAVRIYGHYAVLEGEKMNFYRHPIHKFDFTTLDGKEKWTAYKFTRNVYDIWMPTHFKRICSAIDQIPPDVDFHISQSELQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZU1</accession>
    <name>A0A179TZU1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01406">
        <property type="protein sequence ID" value="OAT01406"/>
        <property type="gene ID" value="BDCG_05142"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05142"/>
    <dbReference type="eggNOG" id="ENOG502SPJ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="532" mass="59445" checksum="ABEC16F27762F76E" modified="2016-09-07" version="1">MTPSQDWNSCCPPSQPQLALALAIVKSKPSNTTIKDHILKIRRHIQNGKAYHAPELPEKHLDSITFWREAYEMSESAQSKLLDKIYELEQRNAALLLKGGESNASETNAPRTKRKINGDGDSTVLSHAQKRAKTTKNGRLNTSRPQSKDFLSGTADELGFSEISTPFLRHFHALQKQLQRKINHEALVSLSVGLCEAIDITIRSRIGDKRTRSNVSVKQKTLQPREPGLQHVLKGICPSYPLLLQTLNKLSDSDDAGSGIGVLTYHIIQLFQKTLGHMHQYIISKGKESIAQGIPAGKKGKQRSKTKMTKTPASPLITSDEELTLNLFSHFLASMILSLNPVKPQENSLLEGFLFSILEKVGRTLCLFVFKELYSNSDLRLNPAKLPMPGNFDKEYPARGEMAIAQRAAECEARHLIWILERAIAFTDQFERPSDVINGDLVLPETTLPKGPPSEGILQRAKTKLQNTLLKGIFGENEPKFRDSLKVPEKPSYSLPEVSSGRSFDSAATDPAEWFTQEVWRLIGWDVLLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZU6</accession>
    <name>A0A179TZU6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 transcription factor, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_04018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT00983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00983">
        <property type="protein sequence ID" value="OAT00983"/>
        <property type="gene ID" value="BDCG_04018"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04018"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="324" mass="35872" checksum="F01CA3722F33FAFC" modified="2016-09-07" version="1">MGLYSIPADEPYMQIILPRAALKEGYVMNSLLAAAAVDLALSSNESESATYLCAALEYSNKASAGFRSQLENINQDNLHLLYHLAALSAIMQFVLPNRHQTILERVEIFFNLMLGAFSIAMFNIKWLTDAPCSSRDILKYMPLSLDILDSDTIAALEKLSTVARQIRVPASSPMAIYAGDETSLASEEYLLTLAQLKYSFREDACGRVKGYFLSMIGIGGREFLTAIKKREPMALFMLMYLGVLMDRASKDYMSWWVGLAGRELIEEVSGLLEHSSISQIPEGREGMSWTRQQVGLAPLTTNDAIEEQACCSLSELSLAFPVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZU9</accession>
    <name>A0A179TZU9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_16668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00548">
        <property type="protein sequence ID" value="OAT00548"/>
        <property type="gene ID" value="BDCG_16668"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16668"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="60" mass="6681" checksum="068F8FBE664F2CA2" modified="2016-09-07" version="1">MMLMMTANIDAKTMEIPITMPGHSAYMMPGHSAYDARPQCLYDAGPPIAHMMTYADDLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZV3</accession>
    <name>A0A179TZV3_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="5">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_02618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ER-3</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00386">
        <property type="protein sequence ID" value="OAT00386"/>
        <property type="gene ID" value="BDCG_02618"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00387">
        <property type="protein sequence ID" value="OAT00387"/>
        <property type="gene ID" value="BDCG_02618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02618"/>
    <dbReference type="OMA" id="KDMRFSF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="PTHR19370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT00387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="308" mass="33606" checksum="4518A275965C11A4" modified="2016-09-07" version="1">MSSWTSSEAINGMYIPSALLVIGTAIVKKEWLPYAAALAAILSGWKVMSNRQRKVLNPTEFQNFELKEKTIVSHNVAIYRFALPRPTDILGLPIGQHISLAATIEGQSKEIMRSYTPISSDQEAGYFDLLVKVYPQGNISKHLAGLRIGQTMKVRGPKGAMVYTPNMVKKIGMIAGGTGITPMLQIIKAIIRGRPRNGGNDTTQVDLIFANVNPDDILLKEELDQLAKEDDGFRVYYVLNNPPEGWEGGVGFVTPDMIKAKLPAAAPDTKVLICGPPPMVSAMKKATESLGFKKAGLVSKLDDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZV6</accession>
    <name>A0A179TZV6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_04225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01080">
        <property type="protein sequence ID" value="OAT01080"/>
        <property type="gene ID" value="BDCG_04225"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04225"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Phe_hydrox_dim" evidence="7">
        <location>
            <begin position="427"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT01080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="614" mass="68333" checksum="92E45143B94F27F3" modified="2016-09-07" version="1">MLELLLARYGLSDSSLLCLDPKLSSLKSGQADGLQPRTLEVLKSLGLADEILTEGCQMWQVAFWNPTADPELVAKGRLIERTSIVPDICVPARFPHEVTIQQGRIERIFEDNLLKYSKRGVLRSSTLVDVKIDEEEDPEFPVIAQIDVAGVRRIIRTKHLVGADGARSTVRSCMGLRMEGDWTDHVWGVVDFVADTDFPDIRRRTAIHSPVGSVMIIPRERIANGDYLTRLYVQVQEDVKPEEGERDGDSNGTAADAKARRSKVTVESIFKQVQSVLQPYYIKPKYDEAVDWWTAYQIGQRVADKFIVKDSKGIQRVFIVGDACHTHSPKAGQGMNVSMMDSYNLSWKLAYYINGLTPASANNLPDPILDTYHEERHTVAQQLIEFDKAFSSMFSGKIDIGEGGNGGGANGLSHEQFLEVFNTGNGFTSGCGIEYPENALVEKTYSGNPVQSIDYLSGILRPGRRLLNVRVKRHADGCPRDLQDDFPSTARFRILLLTSNDLLSPTGVSTTAIKSIACTLLTDRFPPSILELVAIHPELKPDFLWDEVPVELKRHAEMRFYDGSELQDVYATYGVPVDRGVIAVVRPDGYIGVLAALDDVQRIEKYLGACLRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZW9</accession>
    <name>A0A179TZW9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01385">
        <property type="protein sequence ID" value="OAT01385"/>
        <property type="gene ID" value="BDCG_05079"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05079"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="99" mass="10961" checksum="14342924E45C5778" modified="2016-09-07" version="1">MTSLPKWQPESLVRKNGMTEDTSLSTFRSREETGTRKQSLLLKACVVCATTHLDYGSVCRGSCSVEFDFDMRCVRSKTISVRGKAVCDPLGPLDRALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZX3</accession>
    <name>A0A179TZX3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease Dip5, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_04286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01100">
        <property type="protein sequence ID" value="OAT01100"/>
        <property type="gene ID" value="BDCG_04286"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04286"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT01100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="474" mass="52894" checksum="18DF9840DE8D3969" modified="2016-09-07" version="1">MCAVGEMAAWLPTPSGFTGYAVRFCDPALGFALGYLYYCKYIIVTPNQLTAGALVISYWVDRERVNPGVWITVFLVTIVCINYFGIRFFGEFEFWLSSFKVIVIIGLILLSLILALGGGPDHDRKGFRYWKDPGAFNTYIKEGSSGRFLAFWSTMVTGTFAFLGTELVGVTVGEAQNPRKTIPRAIRLTFYRILFFYILSVFLLGMLVPYNSRELAFAAKSSSSAAASPFVVAIELSGIRVLPGILNACILIFVFSAANSDLYIATRTIYGLAREGKAPRILARTDRRGVPIYALGMSALFALLAYMNVSNDSKVVFGYFVNLVTIFGLLTWISILVTHICFIRARKAQGVPESSLAFKAPFGSFGSYGALAFCILIGLTKNFEVFVHDPDTYGNFDYKNFITAYLGVPLYLILIFGYKFYNKTSGVKPHEADLWTGKDKIDREEAEFLARKAAETKSYEKAGFFYRTFVSWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZX7</accession>
    <name>A0A179TZX7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_05195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01436">
        <property type="protein sequence ID" value="OAT01436"/>
        <property type="gene ID" value="BDCG_05195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05195"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="176" mass="19175" checksum="5C07DE025FF06287" modified="2016-09-07" version="1">METGCLRRAERSHNDWGVRQFNPGNLSSVREKAGSLGSLHQTLALSIQARNSVKYCFVKLTTRVPCRWSLAVCASCLVLLIQHNIILCVDYEPRISSTHSLIPGVYMSSSSYMIGIPGGDQHWCCMLGWSYPSLIPQAPVFACMGSAFPGSKLPMLPVQDNGIQETSANKGTLCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0B2</accession>
    <name>A0A179U0B2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00709">
        <property type="protein sequence ID" value="OAT00709"/>
        <property type="gene ID" value="BDCG_03421"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03421"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="526" mass="57337" checksum="C4107AD1F28771D5" modified="2016-09-07" version="1">MVYIKLVKPLLNVRPPGLGWPRVTFRAFASIHTGAMNKEDNNCSKRGGVEVDLRMPLCRSVDIEGLSIPQLHKCLESRKFSVYDLTACYLERIRRVNRVLKAVIEVNPDALDIAMMMDREREQRRNHGLLHGIPFLVKDTMGTKDKMQTTAGSSVLVGTVVPEDAHVVSLLRRAGAVLLGHANLSEWASMRSTYYSEGYSSRGGQCRNPYNLAEHPGGSSCGSAVAVASNMCAFSLGTETDGSIMVPADRNGIVGIKPTVGLTCGKGVIPESHSLDSVGTFGRTVLDAAIALDGIVDSPTGARLDIRSFPTAPFVSFVSGKEALRGAQFGLPWKGVWEKVKQKETARKQYQIFGQVIERIRGAGANVIEYTDFPSAEEIIPPGGWDWDYPTKQGHPEQSQFTVVKTEFYNDLKTYLSNLAANPNNIRSLDDVVKYNATHAEKEGGRPGVHPAWPSGQDSFEMSLETGGVMDETYHHALAYIRRKSREEGIDAALSRGDGRQLDGLLVPLQADSGVGCQVAAKAGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0B8</accession>
    <name>A0A179U0B8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 finger domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01240">
        <property type="protein sequence ID" value="OAT01240"/>
        <property type="gene ID" value="BDCG_04655"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04655"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1341"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1525" mass="165321" checksum="55ACC51008FFF9AB" modified="2016-09-07" version="1">MSYPGFGYSPYQYLSGGQNAQPSYNSLPQIQVTSASETPNTQQTANRSYGQQSYEWQGQNNTDISGQTPQQQPERESWQSSTNPSSQSYRYQHQQQSSYSTSNAAPSISSSLSSQQAQQSQQTHNPLISPTLKNIQYGSPTVESMAMHNSATDPRSTTSISTNMSYQIDPPAQNRLPANVSLPIDRPTSAQRSRTVAASAMTALSSNVPAPRAASQRLSTGPAGSSSTSHSYAPSYGTPLSNLIAPNPTAQPPSSADPGQPYRHQNARSQYSRASTGSAQSNISRNQQSISQHRNTYSSTLSAATPSSSSMYSEPSASQQHRMTGYDNTNAPHQPPTTSHAQNTASNPSYINSTSEYQPVNTSQSQSYQPATPGFIDPSQIYNPYYQEYQKTRVAEAEAEAERLKHPEAEKQKEVEKQREVERQKDIEKQNEPERRKRSARELEEMKKENLKRAAQAEISQKLAAAREIAASVRAANSQTAEKPKPGRKPGPKPRVQAPNPTDSAQGKSGGTQKKQQRRARKPQVEAPALAAPDESSGITHQTQSVPTAQPNEDQRQALSTMVQTPVEGQPDEDEDLEVKLMLEKMKELKSKYPNKFAKLLGGLEVSAPVAAPPQAVEERRTSGVLVSSPPPTSASMNPTEETNSMHDRGKFPAARRKRRSKPVNLAGHGAQSSPTRHDNGHPPQPPPAAASQPETNEKDQPTQMGGRMEIEKLIDSDESQPSPLPAPVQAAAPPAHPVPEPAAEAKQSQPASLPAQVQAAAPPNQPVPEPATGAKQTKEENLRAATIWPEPKRLALAQAASRYIDDVISNRNKGNKCPPEMVLSLIDRNPSYIELCGMLESRGYHLNRVHFAKHLLKAMPELTAGSSPAAGPNTVANGPSSTPRKGQMQPPPSTASMSPPIQYTGVRAGNNSTPIPLGSTARSGGPQVVGSKTAQPAPSSTPMPPPTNRDPGYFVPYQLPPSVPSENRVPGFIGSPPRQVGFSNGTQASRSAGPHSLPERLAPIRHTIGGLVPSPIGGKLKPKFRVPAPPAHIPAPGSKEALAKKRTFAEIVDFTQLPSDDDDDDSPPSKAPRLQDVPPQSDTNTDVDVEVPAPAPETPEAHSAPANTLDLSQFRMPDADSSTSNETLRGRSDIVKPLNKTEAVKTRYYDPKTIARDLLIATGRHPTERALNQHLSRLRDNFPAVDNSSDLRTFRWDIVDPGGPPPPEVPLVTAVSKPPLITVREYTRPGVADRLPNPHSRDSAKGTTGSQPPQTPSQLHISETINKSDDSSPHLRQESNNNINTESSVMSSTPQMPGTRRRGRPLGAKSKPRFADRVEIAIPISSSPNTPRTPFHMYKCEWKGCDAQLHNLQTLRKHATRLHVPRDTKMEAPCLWAGCRDGRNKFTRDSLADHLENKHLSALAWTLGEGPGSVRSGHRDYNIDDCLNDSNGRAVIARASAKGIRPTLILPAAYRSIRSFNKMYGNESDKAKALEVLRALEMKQVRVGTGLGRGGCTFMNEKRQETVVAFESIFEIVAEDDDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1A4</accession>
    <name>A0A179U1A4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMGC/SRPK protein kinase, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01916">
        <property type="protein sequence ID" value="OAT01916"/>
        <property type="gene ID" value="BDCG_06342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06342"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="304" mass="35156" checksum="D13931D52076363B" modified="2016-09-07" version="1">MTSLLRWAKATFRRVPSPPVCFPTSGYVTVSGSELDEERFEEFKKGRYYPINIGDVLTSRYQIIGKLGFGVTSTVWLARDLEGHKYVTVKVYTRDEVNQEEFQIYKYLKQGNPSHPGYVHVRKALDVFTIPRPGGGHHCLVQKPMWESFKDLLYRNPNHRFTEDLLRVGLMQVFLALDYLHTECKLVHTDIKGDNILQEIEDRAILERFAKAEMENPSPRKFINGIPVYASRRFELPKTFGKVVLSDFGSAVRGDERRNHDAQPNVYRSPEVMLKAEWSYPIDIWNVGVMVCFSSVFSHLITLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1B2</accession>
    <name>A0A179U1B2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01926">
        <property type="protein sequence ID" value="OAT01926"/>
        <property type="gene ID" value="BDCG_06365"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06365"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="427" mass="48916" checksum="49CF171D17E72257" modified="2016-09-07" version="1">MQLCNVLDISVPEVVDWSSSSSLSHPNPVGAEYILMKRIKGLQLSEVWPTMSEAQRFRLVKNVVAIEAKLAGIDLLSYGSLYYRDIYPDGLPIAEITSSSHELTVYIIEKFVFSPSTDRMFWVDEKRELELDQGPWLTATEYISAIAKCEIICIQNLNPDESGFNPLNPGRALVCESHIELLEQFLTVLPHILLRMEICCPVLLHHDLHTDNIFVDDADPTKISGIIDWQGVTAGPLFMQARFPSVFDCEDSYPWGAVQPELHNNFDSLSEQEKAQIMEQHDRVRLKKFYELASRKFNPDITKAMDAMRNDDDPTSFVFFLLGQTSVDGPIPLRELLIQIYEKWDWISVKRGLTMSCLINFTEEEISTHWKASQEWAEVFNEFNCLLMEMGGKDGPVSHDEFEEATHRFNEHKEVLEGLQKHLSEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1C1</accession>
    <name>A0A179U1C1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01530">
        <property type="protein sequence ID" value="OAT01530"/>
        <property type="gene ID" value="BDCG_05411"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05411"/>
    <dbReference type="OMA" id="FERANTY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="487" mass="54765" checksum="1E39F9108AD65005" modified="2016-09-07" version="1">MSVTQLPCSRPKRQHAEQFSERSIISQLEPDTKRQKRDPTGRAGTRRPAPEFWDNLSTIWLTKGTLTELDRRNSVRHLVQYAADFLSSCGPDLFKEIKELSKHGGPDLSDLRNFPQYRSPLNRRIDSSQPSLNKRRPSTTAPSSNKRSSRSGGTYSRNFEQHLIDHGIYPEGYRYPSGQKPGKPKNWTVINQQLDRPRGSLSPSRFTEEEFEKFKEANTDATVELLTNSVIPTIEGGITDRKAVGGGYPFGNLKPLTDGTISSAWPDRFFGARPEQLDRQIRCNLHDTIVPSTQDSRPILPNFYLEVKSSDQSAAVAKRQACYDAALGARAMQNIQSYGNSELAYDSNAYTIASTYHDGTLKLYTSHPIKTVGARHEPEYIMTQLNSWSMTGNLGTFQQGATWYRNARDWAKERRDEFVETANAMLLKEEFQQISSSQKVSVSVSTVVSIDSDSSSESDPTEFQDAQWSFAAPIEDVGEEAQILSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1C5</accession>
    <name>A0A179U1C5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMGC/SRPK protein kinase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01915">
        <property type="protein sequence ID" value="OAT01915"/>
        <property type="gene ID" value="BDCG_06342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06342"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="348" mass="40049" checksum="1820EBD6FED5D4A1" modified="2016-09-07" version="1">MTSLLRWAKATFRRVPSPPVCFPTSGYVTVSGSELDEERFEEFKKGRYYPINIGDVLTSRYQIIGKLGFGVTSTVWLARDLEGHKYVTVKVYTRDEVNQEEFQIYKYLKQGNPSHPGYVHVRKALDVFTIPRPGGGHHCLVQKPMWESFKDLLYRNPNHRFTEDLLRVGLMQVFLALDYLHTECKLVHTDIKGDNILQEIEDRAILERFAKAEMENPSPRKFINGIPVYASRRFELPKTFGKVVLSDFGSAVRGDERRNHDAQPNVYRSPEVMLKAEWSYPIDIWNVGVMVWDLIEGKHMFHGNDPDGKGYSTRAHLAEVIGILGPPPLDMLKRGKRSLEFFTEDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1C6</accession>
    <name>A0A179U1C6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin regulatory light chain cdc4, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01936">
        <property type="protein sequence ID" value="OAT01936"/>
        <property type="gene ID" value="BDCG_06375"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06375"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="139" mass="15357" checksum="727EF9277CA4FDED" modified="2016-09-07" version="1">MASTNYKEAFSLFDKRGNGRVALESLGDLLRACGQNPTLAEIADLEKSIGGDFDFEAFSKVLNRPGGFRDPGEPEEYCRGFQVFDKDMTGFIGVGQLRYILTNLGEKMTDDEVDELLKAVDTSSGEINYTELVRTILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1C7</accession>
    <name>A0A179U1C7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT00711"/>
        <property type="gene ID" value="BDCG_03430"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03430"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="329" mass="36022" checksum="CB896766A1FD44DA" modified="2016-09-07" version="1">MRCFWGARGALAPCPPWYKSQRRVFYDILRPPCCDFYCSRCFGGGNGLQHFSAQTIYLPCSPADFVASALLSSLKIPIQFYFPFSLLRRGMGLPNATRPYRDDAPLPSSASAHSLQPYQDLEPEDSPPAYMEEDAAAVVQPVSIITGPNDLSSVTRLVSYYDIPGGRVISSSRAKKTYTVTLAPELSQDPEALSTLVKCQVQRPPMPVIVVKGTHTVTRKNSGSNKGGSNKETVVDFDFRINCINSVLPDVFTSGNRSRFVEIVQDQDGRKAYRGGRFKSKGANKKRGSSGANPGPDLEEAQGLTADSGGPDLKEWCRRFCEDKSGVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1D4</accession>
    <name>A0A179U1D4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chromodomain-helicase-DNA-binding protein 1, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Chromodomain-helicase-DNA-binding protein 1, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_05486</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">ER-3</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002623805.1"/>
    <dbReference type="EnsemblFungi" id="OAT01550">
        <property type="protein sequence ID" value="OAT01550"/>
        <property type="gene ID" value="BDCG_05486"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01551">
        <property type="protein sequence ID" value="OAT01551"/>
        <property type="gene ID" value="BDCG_05486"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05486"/>
    <dbReference type="eggNOG" id="KOG0384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="DUF4208"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="SSF54160"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="285"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="385"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="483"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="785"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1147"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1343"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1363"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1404"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAT01550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAT01551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1549" mass="176110" checksum="F19259E0C96D5C0C" modified="2016-09-07" version="1">MVLPSASMTSTLANGHQSPVANDVQVIDENPSIPTFDNLSDLSETSPDEQDASDEDVDHDQSGDAESDAAEEFNPEMSSDSSDNEDDLDGQASPAAQHHIAEDESDSATEDVSDAQAASFSGNSSTHNQKKGTKRKSPIIDDDFIRNNPSLYGLRRSGRSRSIRQNVQTTSDSDSEAVAPPSKRRRRTPNRPSKQLSRSQSIDSVSDSDSDEYQGSRSRTSKAKRRRMAQSSDNLIPAHAEIRFSTRRANRVSNYNEDDDDDDFEDESEMMTPGDWVTAVDDTTPAIDVVLNHRFKEGIDLSRDDLSRDDFEFYIKWQGKSHYHATWETVASLASCRSVRRLDNYIRKILTLEIQYARDPEIIPEEKEKWNLDRERDVDAIEDYKKAERVIGSREIDGETEYYVKWKRLFYDYCTWEPASLVSEIAQREIDRYLDRTSHPPISSKSESNPLTRAHFEPIHGTPSFVQNGELKEFQVKGVNFMAYNWVRGRNVVLADEMGLGKTVQTVAFINWLRHVRNQQGPFIVVVPLSTMPSWAETFDNWTPDLNYVVYNGNEAARNIIKEYELLIDGNVRRPKFHVLLTTYEYVLVDATFLSQIKWQFMAVDEAHRLKNRESQLYAKLFEFKSPSRLLITGTPVQNNLGELSALMDFLNPGLIQIDEDMDLGCEAASVKLAELTKSIQPYMLRRTKSKVESDLPPKSEKIIRVELSDIQLEYYKNILTKNYAALNQGSKGQKQSLLNIMMELKKASNHPFMFPNAESRILEGKTGREEMMRALITSSGKMMLLDQLLAKLKKDGHRVLIFSQMVRMLDILADYMDVRGYAYQRLDGTIAAGPRRLSIEHFNAPESNDFAFLLSTRAGGLGINLMTADTVVLFDSDWNPQADLQAMARAHRIGQTRPVSVYRLVSKDTVEEEVLERARNKLLLEFITIQRGVTDKEATELKDKMTRAGHQISEPTSSDDISRILKRRGQRMFEQSGNQKKLEELDIDSVLANAEEHRTEQPEGMEVDGGEEFLKAFEFVDVKVDELTWDDIIPREELEQIKAEEERRAHEQFLAQEIERSQPRKRKEPFDGRQERQAKRRARQQVNIDADDVSDAPPPPDPSRPLSEKEYRHLIRAYLRYGDINDRQDDLIREARLSDRDIDVVKAALAEVIEKAHALLKEENNRLDALEREGKSFTKKERKAILFDHQGVKRLNAETIVERPNEMRILRNATADVADPQNFRVPEATKGADYTCAWGAREDGMLCVGIARHGYGAWTQIRDDPDLALADKLFLEEHRVDRKAERMNGGGKGTTKSPGAVHLVRRADYLLSVLKDKISNGASVIAKRAVDNHHRNNKKNAIHSRGNASGSVSASPSPSLSRKARDSDKSRSRVHKSRDSADLSNTPTGDNRPGHGSSKHRRLKDHRRDENDRDRSGKARMKARGEEKDRYRHSNDSGGTGVDNNSNDAILKVIFKPVQEHLRKVSQVTKENIPSKQDRAGELRRLLLLIGRFIRSTLDGNEARASLEDRLWGYAATYWPNKATPAAALHNMFDRLMEVEKAESTQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2A5</accession>
    <name>A0A179U2A5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01853">
        <property type="protein sequence ID" value="OAT01853"/>
        <property type="gene ID" value="BDCG_06200"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06200"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="PTHR40012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="368" mass="39110" checksum="E8B248E4141F6087" modified="2016-09-07" version="1">MNLTASRAEHFDVTLPFLLQQAAWLYDRQLSQVRAQIRKVGNPHSAASSPVPQSMSGSAAIGGQPMKRVGSSASKDLSKLSMRQKEGQVVKQDPCSPPTPIKSKALYPNISSMNPPIQATGMGLQSHRQAAPPYTDSITRNQPSSKKELHTVSSPLTSPPLDQDISPASSSSSSSDSEEEATTRRGPPFKRFGRFSVHRGSNSIDEDEEDSPAFLPLRTHHSQSTQQMGNGTSATLRQEPEAASHPHAPSTEATVPLTRISAPESSASSGSSGPASGTAAHERTQPSRHPTALSPRRAAELARLGPRRRAAGREGSDGTPSMGSSFSDLDDASLTQSALEEALLSTMQRGGVASRMSTISQALKSRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2A7</accession>
    <name>A0A179U2A7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS multidrug transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_05203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01439">
        <property type="protein sequence ID" value="OAT01439"/>
        <property type="gene ID" value="BDCG_05203"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05203"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YMSWRWI"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="113"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT01439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="553" mass="60489" checksum="5A1EECAE832F1812" modified="2016-09-07" version="1">METRNSRNGRISPSIPSVISRTSTIVDEYQLPPLSFTPFAEYVYHSPNGRFSSDNFEECNPTRCGQYQGYQGAEAARLALIQSSSKDPNLVTWSGPEDPENPLNWAHSAKWAAVLIVSSFTFISPVSSTMVAPALATIGKEFDITSSMEQVLVMSIFLLAYAVGPFVLGPLSEIFGRVAILQLANLFYLVFNTACGFAQTKQQILAFRFLSGLGGSAPQALGGGVISDCWRAEERGKSIAVYSLAPFIGPAIGPVAGGFIAKHTTWRWIFWSVSIADAGVQVVAFLFLKETYAPKLLANKAKKLRQSTGNNALRTKWEMENSTFSILLRKSLVRPFIMLGTQPTIQALALYRAYLYGLMYLVLSSFPLVWEGVYKQTTDIASLNYLSLGVGFVIGLQICAPIMDRIYIRLKAHYNDPGRPEFRIPLMLPGGLLVPIGLMTYGWTAQPHIHWIITNIASAIFATGLIIGFQCAQAYVVDAYTQYAASATGAAAFLRTLAGFSFPLFAPTLYARLGLGWGNALLAFISAGLGIVAPVLLWRYGEFLRRKSTYCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2A9</accession>
    <name>A0A179U2A9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 transcription factor, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02256">
        <property type="protein sequence ID" value="OAT02256"/>
        <property type="gene ID" value="BDCG_07119"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07119"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="PTHR36167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
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        <location>
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            <end position="285"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAT02256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="413" mass="44531" checksum="DCA0DC0F53B1E45A" modified="2016-09-07" version="1">MDRPASDYAQPGLHSPNPTLAEPQSERPAAEQTAAAASGQYTSQPEARPATQYTAPAEGRPSNISSSNTPQPDYGLNPPAPAPPQTQPQQQQQQQHQAQAQPQPQAPPPPAARPPPGPYPEYLTRQPQYHHAPHTQPGGAAGMAQATNPSIAASSPTYPPPYSPYNPQGHEMTQYPGHPPPQMYGRPDWPPHQYGQHPHGLPGPYSSPGTTVGSASPAATAGPRPGQVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGAKRTPEEFKEIRKEWKARKKEEENQRKAAEERERAAAQANQQVDGSAPADPSQAAQSTSYPGGIRPQLPPIGYQPADGQVPGQYGASAGAGLVYPPSNGQMAAPYPPANYPHSPYGQGNQVYQPQNQSSSYQ</sequence>
</entry>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
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                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
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            <end position="26"/>
        </location>
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        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="99" mass="11092" checksum="7C20E7500445B70B" modified="2016-09-07" version="1">MESRKYSDLIKQSDGQGSSGDFLQPPRKLGKFLSTEANLDANKPTKALAIGPSQTIDIDIDSDTNEDSNTEDALFMLYSEQNQKRKQQERHNKIEVSGM</sequence>
</entry>
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                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
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        </citation>
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            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAT00532"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="71" mass="7735" checksum="308D01F5651587F2" modified="2016-09-07" version="1">MNITITRGVNDVTDIIITITTNIDAKTMEIPITMPGPSAYMMPGHSAYMMPGHSAYDARPQCLRCQAPVPI</sequence>
</entry>
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    <accession>A0A179U2E9</accession>
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        <lineage>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
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                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
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                <person name="Chen Z."/>
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                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="McEwen J.G."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAT02296"/>
        <property type="gene ID" value="BDCG_07182"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07182"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="SSF49417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="3">
        <location>
            <begin position="134"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="1">
        <location>
            <begin position="134"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="632" mass="68927" checksum="689AF885EA1A8014" modified="2016-09-07" version="1">MFGSSCSSFNAAPGLLMNPIEPSRGSSSTSPSSVTSSYPYASLRHSIPSTATSTEGFSTPSSYSHPTNLQWNDRMGDLRIQRVPALQPPSGMSPPLQSQGTVVPGPTGLITRTDPYSMSYSMNRNAYSSPHHTMNDISRYSQYPATRALDVHTNGSSMYNHLMDTSSRTSQSSPEAPPFNETNVLHSVFTNSHQTLNTEIHAKIHKGFFQVDDKWTCYRRNYFSVSCSFSLRPWTPNSPLYVQLPNSNPQSVRSFAMSISAVVNAQENETRELVQHTPKRDKQSEKKPGRITLHPTQPPSLAMNHPSSLGPNPISFAAPPHTSSLPLDYGSSFGGATQASQPPTSHTFERIQFQKATANNGKRRAQQQYYNLVVELYAEIPTSNGVDLQWVLIAKRLSHPMVVRGRSPGHYKDGRRDSSASMGPDGGTGSSGDGNGGGCLPPGMGHGPRTHLSLMSQYSGSHRAPTSYNYHRLSSTDHSPLTTSPLISSSSSSPDYNNYTMMNGSMDPLETIKDTTTAGAYGDPTFTTASPDSRKICIEPSSLRLHMPSYDDDAAVKTQEEHDATYSAAFDPMIPALQNEHDGSNQYLKRHNTTSYLSQLSGPRFGGSYASRSGDTSYSRFDSTQNPQSLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2F0</accession>
    <name>A0A179U2F0_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02295">
        <property type="protein sequence ID" value="OAT02295"/>
        <property type="gene ID" value="BDCG_07182"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07182"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="SSF49417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="3">
        <location>
            <begin position="194"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="1">
        <location>
            <begin position="194"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="692" mass="75713" checksum="9562697FA73BBFF7" modified="2016-09-07" version="1">MNNTALLQNSFQLEYPVYSESEYITNERTFPSTTSFPTEVVEPGHQRTDTLGHQFGHPGSVPVTNGFSFNAAPGLLMNPIEPSRGSSSTSPSSVTSSYPYASLRHSIPSTATSTEGFSTPSSYSHPTNLQWNDRMGDLRIQRVPALQPPSGMSPPLQSQGTVVPGPTGLITRTDPYSMSYSMNRNAYSSPHHTMNDISRYSQYPATRALDVHTNGSSMYNHLMDTSSRTSQSSPEAPPFNETNVLHSVFTNSHQTLNTEIHAKIHKGFFQVDDKWTCYRRNYFSVSCSFSLRPWTPNSPLYVQLPNSNPQSVRSFAMSISAVVNAQENETRELVQHTPKRDKQSEKKPGRITLHPTQPPSLAMNHPSSLGPNPISFAAPPHTSSLPLDYGSSFGGATQASQPPTSHTFERIQFQKATANNGKRRAQQQYYNLVVELYAEIPTSNGVDLQWVLIAKRLSHPMVVRGRSPGHYKDGRRDSSASMGPDGGTGSSGDGNGGGCLPPGMGHGPRTHLSLMSQYSGSHRAPTSYNYHRLSSTDHSPLTTSPLISSSSSSPDYNNYTMMNGSMDPLETIKDTTTAGAYGDPTFTTASPDSRKICIEPSSLRLHMPSYDDDAAVKTQEEHDATYSAAFDPMIPALQNEHDGSNQYLKRHNTTSYLSQLSGPRFGGSYASRSGDTSYSRFDSTQNPQSLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2F9</accession>
    <name>A0A179U2F9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDCG_04953</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01337">
        <property type="protein sequence ID" value="OAT01337"/>
        <property type="gene ID" value="BDCG_04953"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04953"/>
    <dbReference type="OMA" id="EMGLFML"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="PTHR12701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31" evidence="14">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31_Bap29_C" evidence="15">
        <location>
            <begin position="164"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAT01337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="213" mass="24070" checksum="D7CC3AECD08FD762" modified="2016-09-07" version="1">MTLYYSLVFLLLVVEMVIFVGLIIPLPFTVKRKLFTFISESPVIAKLQYGMKITFIFILILFIDSVNRVYRVQTELSTHSKEMGGAGTAALGAERMEVQARKFYSQRNMYLCGFTLFLSLILNRTYTMILEVLRLEDKVKQLQGDKQAGGKASAKLAEAGDAGEIGRLRKELAAREKDIEALKKQSEGLSREYEKLGDQLSSQNPDSTPKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3C1</accession>
    <name>A0A179U3C1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02565">
        <property type="protein sequence ID" value="OAT02565"/>
        <property type="gene ID" value="BDCG_07791"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07791"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107182" evidence="1">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="116" mass="12921" checksum="53587FD56593EC4E" modified="2016-09-07" version="1">MIPSLLSLTALTAPLLHLLLLLHLLLAHLSTATLLLHPIPQPSKPQCSQYYEPLCCRNSFPQMYPKNAVWAYMCRDPEGGGSCLPTIEEPLCCPPGVSSQIWKWKSSHHFPHPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3C5</accession>
    <name>A0A179U3C5_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein sip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_07197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May negatively regulate the SNF1 kinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02300">
        <property type="protein sequence ID" value="OAT02300"/>
        <property type="gene ID" value="BDCG_07197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07197"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PTHR31315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="631"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT02300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="784" mass="85351" checksum="CC7BBC944032B668" modified="2016-09-07" version="1">MGNTATKEARPPVGTSGRSGHGRGSSGGAVTFGGHSRFHNQSDGSHPGGSPRHFRGSRPDLSFLGIGPAVERDTVVERKETKQERDARRLARERAVRIKERERSMREEHVDGGYLVTQGVYTGTEDFNKAVVRQLMIERRLAPFWKGLEEFSESWTEHQLMAAAKGLPIPAPDEIPPELEYKLTPPRPPEERDLPEQNLNNLTVPITSRSQSYNSDTSFSAHPVSPSISLQPQLSPSGSGSPGPHLFRGRAKTLASPTASSKNSSLGEMSPREIQLPKDPFVNGQPIEAYLYKNPIECPICFLFYPPYLNRTRCCDQLICSECFVQIKRANPHPPEHEHRDSSLPPPPDQPEGQLISEPAACPFCVQPDFGVSYVPPPFRRGLSYLPSNGLNNTLTSPASSTSSVASRNANPQSITTRCRANSLSANSPTVITTDKIRPDWAQKLQMARAQAARRSAAATALHAAAYVNAMSNPSESRDRENDPLAESTFNLAPARASSRRSRVDELEEMMMMEAIRLSLASEEERRRKEEKEAKKEAKRREKEAKRAEKLARKNALYSNNPSSVALDAAGNSTGRPDREPPLPVTVHEPSNDKGKAVDRPASSSEPLHNDPQPPSLPALHIRPSEDDDLSSVFAPSSASAANRSHLRHLSSTSSSNSSLVESTSGELIGSTSAPNSTNSAIEPVLNFRSLDAVIGDEDKSCNEHLEGVTSAKETQQPSTDDATRSSTNPNLEPEVEPAPSEHVSPVQEGPGLNKDEDGFGDKELQSHSLEITCEGSANMETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3F1</accession>
    <name>A0A179U3F1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BDCG_06162</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01839">
        <property type="protein sequence ID" value="OAT01839"/>
        <property type="gene ID" value="BDCG_06162"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06162"/>
    <dbReference type="OMA" id="DIWMQEG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="Mit_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="177"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="298"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="401"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAT01839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="494" mass="54609" checksum="5054EF6D68527CFD" modified="2016-09-07" version="1">MGVESQRDRDQRVAKLWETLDTRDEGQIDLKGFKKGLRKMDHPLKNAEDLVSDVLSYVDTSGDGKIQFNEFRVFVERAENELWRLFKSIDHDQNGHLDKEELRTAFANAGLTIPKKKLDEFFTDVDTNRDGVITFDEWRDFLLFLPASTSNLGGLISYYSALGNLNPEGDVHINEPFQGSGYFLAGGMAGCVSRTATAPLDRLKVYLIAQTVMKDTAFTAAKSGHPLEAVKRMGMPLIEATKDLWRAGGIRSLFAGNGLNVVKVMPESAIKFGAYEASKRMFANLEGHGDTKNLLPTSQFLAGGIGGMVSQCFVYPLDTLKFRMQCEVVEGGLQGNRLIMATARKMWTGNGIHSFFRGLPLGLIGMFPYAAIDLTTFEYLKSILLARKARIYHCHEDDVPLSNFATGAIGAFSGALSASIVYPMNVLRTRLQAQGTVLHSPTYTGIVDVTRKTLSQEGIRGLFRGITPNLLKVAPSVSISYIVYENSKRLFGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3F2</accession>
    <name>A0A179U3F2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDCG_06114</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01818">
        <property type="protein sequence ID" value="OAT01818"/>
        <property type="gene ID" value="BDCG_06114"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06114"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="PTHR28025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAT01818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="103" mass="11635" checksum="DC65C8C2D8050C9C" modified="2016-09-07" version="1">MSLPTLTKETYIQSLEQVLQNINRLNRNLESVITVGNEFSSVEALWSQFETVMGLGNNNNNNDIDNDNDNDNDNENENENEGHGEGAQHDDHDHEDGERGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3F4</accession>
    <name>A0A179U3F4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral peroxisomal membrane protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_07247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02330">
        <property type="protein sequence ID" value="OAT02330"/>
        <property type="gene ID" value="BDCG_07247"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07247"/>
    <dbReference type="OMA" id="EFTTRCN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="Peroxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="5">
        <location>
            <begin position="337"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT02330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="585" mass="63916" checksum="534585BBDD30D7C3" modified="2016-09-07" version="1">MAAIETPWVDSMSPTTYPHDDGALAVPAAASTAVPPTVAAFSPTTISGSSLTSRQRSTIIVHRKSPLLVATPPPVTRALAYSHPFLLPLNRLVGLLSWTSGDPWESFLLVAGFWATVLYGDIILLWAGPILVVLGLILAMYSRRYSPLSSTGLTGEKHGGHGEGDGASKHHKSLDEIVETLRTFTTRCNILLEPLLELTDFLSTQRTATSATTRPALISLTMRIVLVTPIWILLTLPPFCLITPRRVILSVGTVIITWHSKPARISRVILWRSLTVRRLCSIITGLQFYSNPYPSDKGSNAASKSSLLSLNPFRRKSDKNNSAANISMKKRRADSSGVRFTFILYENQRRWLGIGWTYSLFAYERAAWTDEHLNPVPQKDEFELPEVESGNARWRWVPGSEWRIDNNPSDVPNKKSSKSAQGTGENGAGDDEGWIYYDNKWNDGRRGQDGWGRYTRRRKWCRDAELVEISPSSEITPPPSPTLEKGPSPSPSQQNRPKDDDITSETGIKNCPPCDSGKARKRRWFGSSELSRALASSPGSASSLQNSESSSAIPATATGTGASTNASAGTPTTNLASSSCGNIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3H0</accession>
    <name>A0A179U3H0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferro-O2-oxidoreductase, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Ferro-O2-oxidoreductase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_05848</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ER-3</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01697">
        <property type="protein sequence ID" value="OAT01697"/>
        <property type="gene ID" value="BDCG_05848"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01698">
        <property type="protein sequence ID" value="OAT01698"/>
        <property type="gene ID" value="BDCG_05848"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05848"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="81"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="339"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT01697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT01698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="483" mass="53718" checksum="3724252B71947783" modified="2016-09-07" version="1">MDGTVGVTQCAINPGDSFRYDFTISDSQSGTYWYHAHSGLQRADGLYGGLVVHQPSPKAIRGTQSRNAESDILKYKYQKEILLLVGDWYHRPADDVLKWYMRAASYGNEPVPDSLLVNGVGRFDCARAVPARPIDCSSKTPMPHFMIDPTQSYRVRVVNTGSLAGFSLGFSQGNISLTHVDGGLDVQHFKQSKASNSKSIGILYPGQRVDFILQHHQNARGKSSLTVELDPDCFKYPNPALSSAQAFPIYNANSNNIKTYSPQPLHILSSTHINLTQVSSTAAVLSGLPPEAQQTYVIYTKISQMSKNQNMPFGYFNQTSWRPQSDPPHPLVDLDPHHWDKNQFAISTGSKPVWVDLVVNNLDEGPHPFHLHGHNFFILTIHSSSRGWGSYNPFSPHQQHQQYRPTSMDLARALLRDTVQIPPRGHAVLRFRADNPGIWLFHCHILWHLASGMAMVFDVMNGSQTGNGHGLAGGGAMEMCRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4E6</accession>
    <name>A0A179U4E6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3',5'-cyclic-nucleotide phosphodiesterase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01342">
        <property type="protein sequence ID" value="OAT01342"/>
        <property type="gene ID" value="BDCG_04964"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04964"/>
    <dbReference type="OMA" id="GCEFIIS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="PTHR28283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="479" mass="52162" checksum="B34A35D964CC4DAF" modified="2016-09-07" version="1">MTEGPFAGLELPNTTTGANAAYIFREIISSVFITHPHLDHLAGLAMNTPLVEAQSNPKIVAALPPTIAAIKNHIFNDITWPNLSDEDGGAGLITYHRLVDGGNPRLGRAEGRGYIRACEGILAKCLSVSHGRCAQRYHPETGQYHRAESTVFTTESGCLPSRRVSIDTQDLARSYTPNHQAPCAVSSSGKASSLASVESSAFFLRDDYSGAEIIVFGDIEPDSISLDPRNEKVWEIAAPKVANGSLRAIFIECSYMDCVEDSSLYGHLCPRHLIAELQVLAAKVSRATDPEFSDTASRKRKHATASDPILNEPTSPKSTPPRSQSRRTSSSSRSRWRTTRFSGSRHHAPAEAVKPDDAQPTTPPGSGTPMGDDDDDDDHDDHAYDENGYDANDEVGVEKSRDTPEISSHHKPAKRTRSAMDRGRKPLAGLRVYIIHVKDSLTDGLSPREVILDELRAHNEDAALGCEFYAPLSGEEVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4H9</accession>
    <name>A0A179U4H9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF protein, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">GAF protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ER-3</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01890">
        <property type="protein sequence ID" value="OAT01890"/>
        <property type="gene ID" value="BDCG_06290"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01891">
        <property type="protein sequence ID" value="OAT01891"/>
        <property type="gene ID" value="BDCG_06290"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06290"/>
    <dbReference type="OMA" id="DNYIACS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="97"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="190" mass="20538" checksum="D3219D79E50FB448" modified="2016-09-07" version="1">MPHADSSYFAPGLSKAEVYSQVLEQAKGLLDGQRNWVSNLANVASLLWHAYAALPTPSSNVNWAGFYVRQDKFPSLASPDSDTKGTPSTKTLLLGPFQGKPACQLIQFGRGVCGAAAERRETVLVTDVLNWEGHIACDAESRSEIVVPILVNGETVAIIDVDCTQPSGFDDVDRQWLEALAAILSDSCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4I2</accession>
    <name>A0A179U4I2_AJEDR</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDCG_05025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAT01372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT01372"/>
        <property type="gene ID" value="BDCG_05025"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05025"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="149" mass="15909" checksum="0F47235F3B8CDDD6" modified="2016-09-07" version="1">MVRNSPSAGNNDASDNHHDLIPGPHDKYTANNKAPLANDTRPPPPQIDPTALKAEDISNSTVSASTQASSASEPVLHLRGGGAIASVIVPDPYPDDDQRPSRVLWYVSTGTGRRPTFGEIRRARTMQRSNSDGRSSYGGHVPEKTWAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4I4</accession>
    <name>A0A179U4I4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT02914"/>
        <property type="gene ID" value="BDCG_08670"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08670"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT02914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="218" mass="24631" checksum="358F731FF3A6AED5" modified="2016-09-07" version="1">MGWVGGGFQYDFGKTIHEDNFIQTGVLNQPPTVLQAVNRLKAHFENEGLELMKVVNSVLEKKPRLQKKYKRPEPSSDRLYKPGFIHPLNIKPSCAVVCGDHPSKLTVRAQRTEDGDYPAIHYGLIASGNQLMKDAMIRDRLAAEKDVLCFEMEAAGLMNHFPCLVIRGICDYSESHKNEEWQRYAAMVAAAYARDLLYRLRPGNVEVEKPIRDILSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4J4</accession>
    <name>A0A179U4J4_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_08200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02730">
        <property type="protein sequence ID" value="OAT02730"/>
        <property type="gene ID" value="BDCG_08200"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08200"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="SSF56204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="3778"/>
            <end position="4114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="929"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1561"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1667"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2042"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2130"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2413"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2720"/>
            <end position="2754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2899"/>
            <end position="3010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3073"/>
            <end position="3102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3373"/>
            <end position="3486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="1081"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2075"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="2147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="2428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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            <end position="2448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2464"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2525"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
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            <end position="2601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="2956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3373"/>
            <end position="3402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="3403"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3448"/>
            <end position="3484"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="4081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT02730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="4114" mass="457473" checksum="A23CA17C9BF2D89D" modified="2016-09-07" version="1">[encoded data, 4114 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5I2</accession>
    <name>A0A179U5I2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_07534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02467">
        <property type="protein sequence ID" value="OAT02467"/>
        <property type="gene ID" value="BDCG_07534"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07534"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT02467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="447" mass="52028" checksum="00FFA7EDBB9491C7" modified="2016-09-07" version="1">MDRYYYLPCPLCEHNVVISQTEHYRVLPLDRTQEAVMMKSPRWEPPHKIKVGDLCFIQGRSYPKISYLQRAWLLHKRCLEFVEQLSTTKLYHLLDLIEPTFLARSAPKTSVHGAFYYPQPKKDDPNYAEKVIPQSETTYIDQLMSFAKYLWMFIHGFLLRPLPGDRQTLFFQRLPEEIWDMILEHDIGRLLFVLETASQLTGKRDTPLIIPTERFTIKESKIRSPAIRIHCRNIGRRSYIHHVSNPTDSDTEGDNLVDYMLNDSKYLAIKSDGIGVVDISFEQRNGQPHWALDTPVRPFHAEISEIRATELQCLRIICDSQKCRAIIPSNRTGPEPFFSKTPFPPNNCWVDCGFSALELTPGNPFIHIAKATYIPFANLEKIALEVDTSRLGITEIRLDSKDERDHVVHFPQPPRQVKFQVCTVPLGFKYPYLQVSPFCSMYRWHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5I9</accession>
    <name>A0A179U5I9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin thiolesterase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_09105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03080">
        <property type="protein sequence ID" value="OAT03080"/>
        <property type="gene ID" value="BDCG_09105"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09105"/>
    <dbReference type="OMA" id="CDIKVDV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="618"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1286"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT03080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1312" mass="147163" checksum="9F40940CDC14ECF4" modified="2016-09-07" version="1">MSHMAVSPGPGKTTPRFIQDVLSFDPANPPSSSFNLLTQFPPPFHDPDDYPELISPKACPHQYITKANQTELPPKGFQAGLRTPYKVSAMCLICRYHLEIKMVHTTEASHCPSQLHHIVYSHSDGRQVSNPFWEKGQRLETHYFRCSYSTCAAVISLKLLSPVLTPHWVNILTNKELLKARTDEAMETYPERLEGHSRPFPITVLTNLRTYIDNALHDSQRSKSISMSNKRFVVCFGVDGRPCHELLEFLEFHAREDSWDPPCPDTSDHVPYGNPLNIFLDNVSNELSALIHRRPAHEKEGQPPGIPLDPAISKFNQLLGSSNYDRTFFLNPVNEEVRRAPYYEDLGATEDMSTDLIIEAYNRQIETDPRQGPYYLRCLRYIGEWRSASDGGKINDLVALECSGSRYADDDIPRAYKYFQLDYRNRNLTDDDIIVSFFARLRDTANDTETRRQLWRIGDSRGSEKIKSVAEERVSTVEQALLYLGVESDTSDDFIVSMYAAKVNDQPATKELARKAVALIAEARDSNSLKYFLNTGEAAAAEMDVGEAFRLLQIPDRTVDDAAILAAFSVCCSEAPGQIETYRRALDVIGRDKGSAMISSTLGQNATLANRVLKEWPVGLQNIGNTCYLNSLLQFYFTVTPFRKMVIHFDDYKMPLDERSLDRKKIGSRKVSVVEIERSQKFLVELQSLFKKMITSPTSSVMPEQELARLTLISSSNEAAIRRKSLISSSRPSLGEINGMPVLGPLGPPTATTAEVSKDAAAVDASNKTLERSDADSDITLVSLTAQADNEESQVNNKENIGPAPQEITVEMKEVDDSNGVGAGTGDSMQALAPIGPPNRPPPVPPRPTPLRPAPLDYQQQLREEVELGAQQDVTEVINNVLFQTQCAVKPIRFDQDGEQLDVVTDLFYGKTVSYIAAENGVRSKEESWSDIKVDVASGSKDIYSAIDGAFDVQKVEVDGAEVEQYGAISKLPPVLQIQVQRVQFDQVKKSSFKSTHHLELKETIYLDRYMDSNKHNLDERRRECWRWKDELRKLRARKAELIDTESWACLPDVFTETKAYIQSLMAIEDEPDMADEALELDDGILSRLTAVEEMARDEIKCLEARERDLVALLDSQFTDLRHLPYRLYAVFVHHGSVEFGHYYIYIFDYDKNIWRKYNDSEVTEVHSKSEIFESQNLTNPPTPYFLVYVNEHMKDRLVKPVNREIEDVSPPEAPPIPAQAPAPAPSTVLRGQQANGSGPSQTRTPHSGDTEMEDPPAYNEIENVPAGAVVTTEAEAAVSPSPPRNRLKRKVEGETRTDDEPPGTLGPKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5J5</accession>
    <name>A0A179U5J5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar segregation protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_06015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01772">
        <property type="protein sequence ID" value="OAT01772"/>
        <property type="gene ID" value="BDCG_06015"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06015"/>
    <dbReference type="OMA" id="GLWCRVC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="SSF140125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="149"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT01772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="471" mass="53649" checksum="451B882D87FC10AB" modified="2016-09-07" version="1">MYDVCLEPMCQKRLTVTSGSVNCRKCGKLFCEEHTMYQMKLSRSAQHEPVRGFWCRVCETCYKSREGYKSHNGQERDHTALFTDLRRQKVDKAFLEVSRLEKRLTRLTQLLSTLPADQIQSGANRRWSIAWQNDQRKKLEQSVVSWQDDASVPRCPFCQQDFTSYTFRRHHCRTCGRVVCGDPITGCSSEVGLEISPNIQVSEKPPTTHEKINIDVRLCKECKSTIFDRRDVAQDLIKEPPDLRAYKNLVQFEKGIRLLLPRFQKLLSALQDPDKTPSPTQLSDASKVRRRLMDSFAQYDVAARRIRDLPTQSPTQAKLQKAIYHQATNFLHLHMLPLKSLPKVLKHATPHGSKLLPNTNTGTMNGGTSALAAIRYGNRDSVNSTTSLASDNSSAISALETEEKSLRERLIVLEEQKFFVTEMIADANRRRKYDEASSLAQNAEDLSKEIDRVNGMIGQLDFEGLYSGQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5K0</accession>
    <name>A0A179U5K0_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_09120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03090">
        <property type="protein sequence ID" value="OAT03090"/>
        <property type="gene ID" value="BDCG_09120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09120"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="PTHR39468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2" evidence="2">
        <location>
            <begin position="185"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT03090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="482" mass="54597" checksum="56B4C8E5631E7FD0" modified="2016-09-07" version="1">MIPTTQKDTARTPDLQKARVTLEDPAPSKESDPIERTPDWARMGDRHRSSYGSEIKLGTAKAGKSAPLTKIAASERARPKTWQENTMSRQSTDEPLGVRSIERAPLEKAIHIPFEKAVRRRKDNPENWQEVDMPDRNTDGEQTLRYQGKVYGFAAGDKDEVVSGMGAFGPGKLAREVGNRAIKQISAELDDCISSGKGDIGIWDVCEEHIFAMLKLFSVEDEVITSTMPRYGTATQRMRRADKRNSQKHHAKTDMESEAASLNNSPSSNPLYIPPGIPRKPFVLHAFPATLLYALRLLHSHFPMSEITIQMHAAIKARGRIARLLASDTEIFNELISYHWHVHNNLPQVNSLLQEMEDNGATISSRTIELLDEIFTQKREERLLGGSSATALVKGTPWAFDPALRAYKDFVGIKGQFEGLFSKVKRLRRFEGHKSKITEKMHRKLPVDIKGSASSEYSRLHRRRRNFMPYIEDDAEEWEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6L5</accession>
    <name>A0A179U6L5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02949">
        <property type="protein sequence ID" value="OAT02949"/>
        <property type="gene ID" value="BDCG_08776"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08776"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="414" mass="46872" checksum="ACB88F37535E5327" modified="2016-09-07" version="1">MFLAFAPGPIAEKAIDRWIGQVGEETRAKPRQRHRALSPASRSRLETKELRLGLLLAASRGLVGCLHALASTAVGWGIGIAETSLHSTSILREAVRSGKLGVVNFLLDRGVGPRDRDAIIPDWAQLPIAMAVQRLHVDIAAAILAFDPVPDQGYVLFRDDECGRSARVDDIDCWCLPGRESEWRLERLRYEIDRLDVVVKQIGDFGFAECQHLELVSWAAYRSSMPMLKLLVERYSFTVDVERDLYWAFRGGADVDVIRLLLQHGKRGEVAAPVLPNDFLLSRYRIKSKPRSGAAGNWDPEFTRSYYDMVPLRQRVPVIDAVTYCNVDMVKLLLDTLSDAEEVNRTVNEFDPFWRTPLHYAVEKGDQDMVRYLLECGAEVWQSCFDLVSREGSTDTVGLVTRWMKEHDLEVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6L6</accession>
    <name>A0A179U6L6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02938">
        <property type="protein sequence ID" value="OAT02938"/>
        <property type="gene ID" value="BDCG_08734"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08734"/>
    <dbReference type="eggNOG" id="ENOG502SK65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYWCKTI"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="460" mass="52399" checksum="9F49E9E7B85AA0E0" modified="2016-09-07" version="1">MARHQMMPSIECQTPIVARKHLAPEAKGKQAKRVKREPQKQQPKYYRRSVRLSNKKALTTDSPTRIHNREQNTKPNDKRPCEDQARSSPKRPRSSTSLAIEYPFVEEQRDIANWKKVDLIGYWCKNDRWPIEYFEAQPGQIENMSHLLAKKKSTASLRRKNSNSSLVTGSNTPTDQESRDGKSASTEDISRVIVPSAESLAVDGAKTLKHLVESVNEQWSSSIAFCGPRPQPDYAVGFGRSAFTEDQLKTFEPFLGYDPDTYSSYFLATFYMYFPFLTSEVKGTAALDIADRQNAHSMTLSVRGVVELFKLVGREEEANREILAFSISHDHRTVRMYGHYAVIEGDKTSFYRHPIKTFDFTSEEGKDKWSAYTFTKNVYDIWMPDHLKRIRSAIDEIPRGVSFDLSQPGLGLSRSNAPSFLDEDDSQPSQASFVGSAEVTPNTSFTQQTQQALKRPRRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6M5</accession>
    <name>A0A179U6M5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2 family protein, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_08804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02959">
        <property type="protein sequence ID" value="OAT02959"/>
        <property type="gene ID" value="BDCG_08804"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08804"/>
    <dbReference type="OMA" id="RGVYLLW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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            <begin position="407"/>
            <end position="521"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
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        </location>
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            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
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            <begin position="236"/>
            <end position="354"/>
        </location>
    </feature>
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            <end position="43"/>
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            <end position="197"/>
        </location>
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            <end position="258"/>
        </location>
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        </location>
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        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OAT02959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="540" mass="58888" checksum="D0544BD2FB316709" modified="2016-09-07" version="1">MNRPGPGQQPLRGMSGFPAQQQQQPQTRPTNPSLVSTRLPNGTAANWGFGLPMGGAPGLQSNQQRTVNAMNSFAQSISGSQPATPLDLSEFPSLSSVPQQSQPSASGQVTWANASQRVNQQSAIQRQSQTPATSQPPSRVSQTQALSHQPPSQSHASHEDLFPSATQFAAQLDDFRNGGQGISGQLSGGTQPQTGNIDEFPPLGRNGPADIGQERRASLLQSGAFGNYGGGMAFPNLNQSHSGQGRTLLGNMVNGQQDGRIMSPGAGGSGVMSTSRSPMGQVQNGGLSQEKDDLGASSMQRTIRPEAYPEQQSQPIMQQPPQNRQQKSGNFGDEGQEQSQQGQSSEQAPLTQLSDRDRFGLQGLLSMIRSENPDVATLAVGQDLMTLGLDLNQPEPLHPSFASPFISSNAAVPLQVDFTLPACYNVANVQPLQTRIPSFSDETLFYIFYSMPRDVMQELVAEELMSRKWRYHKVERAWLTRDEAYIVEMERGLSERGIYIFWDTTTWKKIRREFVLRYADLDNHLDRRGYAQGVAFPQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6N4</accession>
    <name>A0A179U6N4_AJEDR</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDCG_07857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="BDCG_07857"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07857"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="382" mass="41841" checksum="E85260CDD1980519" modified="2016-09-07" version="1">MRGPDGYHIASAVNDDPASGSDHLSNEHESGALDPEDKVCLDLKEKQVLTHDYFVDAFELEQSTAPLVVEEVGKISSSIDELKFPSHFTREHNPLPETFINSLEEDWKDLRSAKPPYGMSSTNGFATDIWTIQECTTAEMEQIDAGLHSILPQFVNRESHATSSSRERNISPHQQQIEINSQLGGSDGPASPALENNNPLHTDLKCQTEKTPAKPIFKINTNLSPMLDDSTERDLSISPLSYAQSWTSRSTTGKTIIDANGLEKVLTPVEEQQRRLGLQRAVMEKMSGGFSVPTSPDTNRATAAIHSNPPPPIQPTPPTSPAWNMANAKEQSATSKPVDANKLDEQTKNTLVRKLSLLTLGKKKSVAKINNVLGFSAIVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7M3</accession>
    <name>A0A179U7M3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein, variant 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BDCG_07618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02502">
        <property type="protein sequence ID" value="OAT02502"/>
        <property type="gene ID" value="BDCG_07618"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07618"/>
    <dbReference type="eggNOG" id="ENOG502QRPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="518"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="643"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="301"/>
            <end position="396"/>
        </location>
    </feature>
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        <location>
            <begin position="598"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
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        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="762" mass="81461" checksum="90EB8EE950DB5025" modified="2016-09-07" version="1">MPPKKMSLESALDEERREILDILEGRLRRSPQQQPSRARHASPTPPIRSMLDVAPDPALQRHNSIAGPSASVGVTTPSSSSRSAPPVRSLLDPISPSPLRLTHSAESRPTEYDPATTSPILPTSPTSPKSPKSPKSPNSSISSSTREESHPRRSSEPSGHSGSLPSPTRKKQGIEEYQFEMLPSIPNQALPKRVAQGGKKSATHTNNAAHTSSMVAVMSGQELGGLHGFTRGRDTIRHGGAVGVSGRHSRSPSARLARSRSPGTGLLNTNSFNPMPVPGTFVTDTGKVIHLDHAYRQLSNAALSRSSGTLSRFRKSPTSRERGEDAVSESGDSRLQEDYYSGDEAVSGDNSSGDENDNSSSGEEDWSAEIQRGRRHGRKKSDSEENGVNKSGGPQQVRSLLAAADEERKKVSSTYKVKSLLDPVPVTAKAATEKHLHKKTGVVHPTTSFDYAGSGANTPAGSDDEAQYSDFKKAQNLSIYMSPIDQSVPNRVIRTIVRGEFTRVQEEAEQNGRMRLRTYLVATDLSDESVYALEWTIGTILRDGDTLYAVYAIDEETGSGSGAGKGEPDSSSSVQIGDGLKAMLDAAAVVGSQTKKTAENLTKASPLPSANTSSTQISGGSGGGGGTDSKPGSADSRAVSKDEAERFRAIEGISQTVVRLLRKTKLQVRVAVEVIHCNSPKHLITEAIDGLEPTLVILGSRGRSALKGVLLGSFSNYLVTKSSVPVMVARKKLKKHAKFKPANVRLLNNLTTPKKLVYAKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U816</accession>
    <name>A0A179U816_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWWP domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02672">
        <property type="protein sequence ID" value="OAT02672"/>
        <property type="gene ID" value="BDCG_08049"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08049"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="SSF47676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="147"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="587" mass="63930" checksum="565DB3AAA31314B2" modified="2016-09-07" version="1">MAEDANPAASRGDSVPETTPSANAAPNTPGSPRPEKDEQADVKKPEDASADAAASEKPEPAATDASTDAAKPGSAAETQEQKTDDSAAPAEETAETASPTADRANGTPAASKKSSAAKRKSTGGDTKGKKLNRKKSSARITHLDAKPGEYYIARLKSYAPWPSIICDEEMLPPSLLSTRPVTTKQQDGTYREAYSDGGKRVHERTFPIMFLYTNEFAWIPNTDLTPLDPESCKDVNEKGKTKNLIEAYHVAAENHDLQYFKDMLADHQRALEQDQEEREARAAAKAAKQEKKKRKSMDVADEHEDEAAETGAEKRKTTKKRKKDGESEAESDKPAKTPKTATKLKLTTPKTPATGEPGKKTAAKPAKTKATSAKKSKKETKATSDEDATEAPKEAEVEKPIDPQEAKLKKEKEVLYLRHKLQKGFLTRDQAPKEEEMASMSNFIQKLESYVDLEVSIIRTTKINKVLKAIIKLNSIPKDEEFNFRGRSINILNKWKTLLDSDIPPPKEKEEQEPEPKPKANGHNQVNGRKAEEVTEGDDEAAGGTTSTPRADEDEPMPDVPAEVGAKAHGERSGSSPAEGEAEAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U819</accession>
    <name>A0A179U819_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 transcription factor, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_09205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03121">
        <property type="protein sequence ID" value="OAT03121"/>
        <property type="gene ID" value="BDCG_09205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09205"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT03121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="392" mass="44963" checksum="7F0D8355BE6A0688" modified="2016-09-07" version="1">MYGVSCDYSALAVQRHQPITHGESYQMAAGTYIPPSSVQFSMSVDDLADKINRVLQLDTSTDKAFLPVMKSISHRTVEFFHHFITMAAHASSLSDAHRVVMSGKMMQLAFQNPYLMHAVFGVAVTHLRHLLPHDKSFDIAAAIHWENALKLYRKEISKPIDEHNMDPLMSTCMLLGTIIFSSEECKPANSWIFSSDPTRLSWLLGQSGLRYILEAVSIQQLQQSIWFEAFMESDDENHSFNNNSPGREGLHPELADLCEIDETTTEESNPYHWPLRMLSPMLPLKADRNNFGKLITFIGRLEPVYTKLLQEKDPRALLILSHWLGKMCEEDQWWIYHRVSSECFAICMFLEHNEDPRIVNLLQYPAEKCGYVLDHVLKEMIVQDSDNLVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>C5G7Z1</accession>
    <name>C5G7Z1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY_DUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="EEQ84551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626483.1"/>
    <dbReference type="EnsemblFungi" id="EEQ84551">
        <property type="protein sequence ID" value="EEQ84551"/>
        <property type="gene ID" value="BDCG_01356"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01356"/>
    <dbReference type="eggNOG" id="KOG2427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007080_2_0_1"/>
    <dbReference type="OMA" id="HEDIVWE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:Lys48-specific deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="PTHR18063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY_DUB" evidence="2">
        <location>
            <begin position="411"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ84551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="875" mass="95989" checksum="7C098688679D4416" modified="2009-07-28" version="1">MALRKDLPNDPDGQDDERSQNDLSYRAWDPIPSAQVSPSSQATASQPEFSDSAAPGLNHAPPSGVVCDEVPNPWTQELAYRPATRELPLSSQPSELDDQRLQESWQREGCAGIQDFSRGEPEKEQDGAAIFDSQDKPSTSSSTEDGRHTTSPGQLRSNNPFLKARHNSGGLLKQSIPGLDPFEFPQSSSLDGHQDGELVTHPYNSNGPDGELSKSSFHIPYEHGHYDLDTEPGPRGAGSSSPFLEEGKAPLVYGPPSILIQSSDPYHHLDKVDHMDQNLQPPSSSQSNSSRNLISFEEENEPNGNTTTDAPSMSSVIDDHPKDLPNETPSISDELDSSTSMSVTAGTSLEQVKPSLSHLSESGQPPAILQKKLSETYDIRQVNWTDGTTSLRTSPVLVQNENGPCPLLALVNGLMLRSRADSPSPITKALQSREKISLGLLMQALFDELTSYLDGADKLPDIEALSSFLVMLHTGMNVNPQLVMQIYMSDSPGTFLETNDTILYSSFKLPLVHGWLAETSSAAYAALNRVAQNHEDIQLLHFRKEELESRVFRGQLLTTDEEKLIEDIDTIQHFVDVENATQLSAFGLEHLQRCLKPGSISILFRNDHFSTLFKHPLSNQLFTLVTDAGYANHAEIVWESLVDVNGSNATFFSGDFRPVGNFSPSIAGPQHPSQNDLAISSGLTHRNNPDGTTGRQLNNTEQTDADYAFALALQFQDEEEQRRTNPRNQAQIQTPQLRTSQSQGVIHHSSNRPNFNHRQSASSTGRRAPQQTQEVRSLVPPPRTSVADPSADAPPPTYEQAANSPVYTPPSDHSQYDGSQNSNTSIAGPRSSSYGLNNTGPNRVHDGHRRVHALSNPSLPPRPRDRDRNKDCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>C5GCP8</accession>
    <name>C5GCP8_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_02397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="EEQ87277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622695.1"/>
    <dbReference type="EnsemblFungi" id="EEQ87277">
        <property type="protein sequence ID" value="EEQ87277"/>
        <property type="gene ID" value="BDCG_02397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02397"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="12">
        <location>
            <begin position="80"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ87277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="214" mass="23132" checksum="493EE788FE042EFB" modified="2009-07-28" version="1">MSLPTSNLPTSKHSDATTTQDAPHPPTNTSAAAELTSLKIRLRGALRQFPDFPSKGILFEDILPIFADASLHEALIRCLELHIIETYGHDQKPDVIVGLEARGFLFGPSLALRLGAAFVPVRKKGKLPGPVETETYQKEYGQDFFQMQVGSIKPGQKVVVVDDIIATGGSACAAGTLVQKLGGTLLGFIFMLELDFLKGREKLPAPTYTLLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>C5GGY7</accession>
    <name>C5GGY7_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="EEQ88382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ88382">
        <property type="protein sequence ID" value="EEQ88382"/>
        <property type="gene ID" value="BDCG_03502"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03502"/>
    <dbReference type="eggNOG" id="ENOG502S8FX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031555_2_1_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="75"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ88382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="360" mass="40718" checksum="460C99A68248F010" modified="2009-07-28" version="1">MPSVISPVAPAVSKLDRMAPEVHNLDPDGDVMLIMTRYLECEIISELGGDFDSTVTKQNGPVAVDTELPNTADHNDILTCEQEVLVRASSRHLILASTVFRAMLQRKFSECNALHETGSVEIPLPADDPDAFLIILNIIHGYMRRVPTELDLDTYTQVSVLADKYDVHEAVEIFANFWFEKLKPTIPQTYTEDIPGWICICWVFNRPKEFKHLTRLALRQGRQNLPLGDLPIPASVVDAINSQRIDSISRIVSLLHAQLADYLEKEHCSFECDSLMLGALTKRLKALHLFPSRPDPPFTGLCFEQFAHRFRDGLYFPAAQRTSTYYYDHAKCAIPSIEHTLKKFDEQLAGLELTEHKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C5GMC8</accession>
    <name>C5GMC8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Choline kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="EEQ89677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622138.1"/>
    <dbReference type="EnsemblFungi" id="EEQ89677">
        <property type="protein sequence ID" value="EEQ89677"/>
        <property type="gene ID" value="BDCG_04797"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04797"/>
    <dbReference type="eggNOG" id="KOG2686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_4_0_1"/>
    <dbReference type="OMA" id="EREGGPM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline_kin_N" evidence="2">
        <location>
            <begin position="229"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ89677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="802" mass="89552" checksum="2B49887EB781261C" modified="2009-07-28" version="1">MSPIAEQQLSKAPTDSKGHTVAQNDISRDSETKVEASDSQAQPANGDSTGLTIAGDRSPRQHRASIGRRVTTRPLPHPSSSSLNSLSSQIHSLNFETVIQDDDEPGIRHRDIEENPHAQRSLFAQVLDWLQHEKAKAVARASKRAGDSQATLPDITTGDATSTLTRGRSDSQASEGTLALEKLEQILAQYAVSGIEGISSAPIGRKRSSSSLKRRAGIRCLRRGSTSDSDYSDADQPPPSADVVLDNSKTLLYGGGEADNDFGSQSSLNNLPAKAKGHWLKFKFEIVRLTHTLGFRGWRRIPLEDCSNIEVVRLSGALTNAVYVVSPPKNLPLPSSSGSSSVMPRHPPPQLLLRIYGPQVEHLIDRESELQILRRLGKRNIGPRVLGTFNNGRFEQYFHARTLTPRDLRNPETSKQIAKRMRELHDGIELLPEERESGPFIWKNWDKWVERCERVASWLDSEIKSPLNQSKLESEPWRRHGFVCGAPWPKFRKLVESYRKWLDTCYGGAPEINKQLVFAHNDTQYGNLLRLEPSGESPLLLPANEHKQLVVIDFEYASANTRGLEFCNHFTEWCYNYHDPERSWACNTKWYPTPEEQDQFIRAYLNHRPRTFHPPETQSAPTSSAASMSAASSTAPTPVFHASHSNSPRITPFMLDTQVPPFPTSSSQDHERAEQALDLEVRRLLRETRLWRAANSAQWVAWGIVQAKISGMEEALAASSAPVEAESGTTGEETKSDTIELDRRSEQSSDTIGEPVGEFDYLAYAQDRALFFWADVLSLGLIKEAELPPDMAQRIKGHILGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C5GMD1</accession>
    <name>C5GMD1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_04800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="EEQ89680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622135.1"/>
    <dbReference type="EnsemblFungi" id="EEQ89680">
        <property type="protein sequence ID" value="EEQ89680"/>
        <property type="gene ID" value="BDCG_04800"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04800"/>
    <dbReference type="eggNOG" id="ENOG502R6NR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018979_3_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="SSF57701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="567" mass="63448" checksum="1ACC7D268B99137F" modified="2009-07-28" version="1">MAGPGGGPPRKSHTKSRKGCKTCKRRHIRCDETNPQCRNCTKHNVRCDYMDNVISQEQAVAPRTGPDLLMSSQIDIEIDAWLKTGNPPFPELQLSSREYWFKFSRTDLRLIHHISGLSIDLHRRGYSNCTVWAQKMPIFLAIALSTEFVMSAILALSASHLAWMTQNPETENLAYHHRGVALKGLHEAIGAFSRENSDAILAASMLLSWQATEWRSWASLQQGVSTVLNSMQPWWKEESELAKFMDSQRAFRSARTPISPSYPGAMGQFQDEDLMRLDRVVGNLINIHQRLSHNQEHYQRVTDLLNFVQQLRTDMPVQSPDRAFERLQPLRTWLFWLPPAMLRGGETDLGALAVLSQFFGIALALEPIFPEIGGSYLGTMAVLPIEDIRRILHVRKASQPFAPEVQLALGLMELPCEIVAEYRSRLHWSPRNSFDAYSPGSHSPYHTLPNLHLASTSPSTGSGYSAYTTSPLHSPLTPAIVASPYQMPAIITSRRQSQVYTTSPTLHPDHTDDRVGGDYKHNPQTHSPIFNPAYLGNLIHGSPVMGTDFNESPTLSVSGGLVIPDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>C5GVW3</accession>
    <name>C5GVW3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_08637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="EEQ85368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002628798.1"/>
    <dbReference type="EnsemblFungi" id="EEQ85368">
        <property type="protein sequence ID" value="EEQ85368"/>
        <property type="gene ID" value="BDCG_08637"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08637"/>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017594_4_0_1"/>
    <dbReference type="OMA" id="ELMYEME"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ85368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="700" mass="78611" checksum="B2A21BF91E25458F" modified="2009-07-28" version="1">MSLRKPPSSSSLLSPAAYDDDVRSLRSLSDQDSDSEDDELVKGSRTTLELSQHDRTVLEEEEERERLLVKKSPTHGLRRIFGHENGNSVRIGKQERRRQRRLQRRAERIKSMGDKGEEEGLMFEMEEGTFHDDASSDSSAASSDLVHVTSRSSWCWKLALLSLSIIILFLILFLGAYKESIGFRTSRRQRTILSNGTSLFLPTTILISLDGFRADFLNRGLTPMLNSFIANGVSPSYMLPSFPSVTFPNHFTLVTGLHPESHGIVGNTFWDPALGEEFYYTDPARSMQPKWWNAEPLWVTAEKQGVRTAIHMWPGSEAHIGSIEPTYLDKYNGKEDLVQKANRVISFLDLPGDKEAEDLPPTTSRRPQLIAAYVPNIDADGHTFGPNSTEIRNTIAQVDQMLANIFQGLHDRNLTNIVNVVIVSDHGMATTSTDRLVQLEDLINIDLVDRLDGWPLRGIRPKRPEDLETLKQQLAESSKPYRDSIEVYTRETMPDRYHFSRNDRIAPLWVIPKTGWAIVERTSFDVKEAKKNNEVYHPRGLHGYDHEHPLMRSIFVARGPKFPHNPNSRMKNFQNIEVYNIVCDSLEIEPHPNNGTLRLPLNPIGLHSPENSPGAETPDDPPISTSPSNAAITSKPHTDAPNQPPVTISADAPDPTSISENGGQDSDASSKSSPSLWDKLLDKIEQLKNWTQGLLESIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUG7</accession>
    <name>A0A179TUG7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99503">
        <property type="protein sequence ID" value="OAS99503"/>
        <property type="gene ID" value="BDCG_00601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00601"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="500" mass="53835" checksum="9BDC11AA107F770C" modified="2016-09-07" version="1">MDGPPPPPPPHGTPPGGRPPPNANGGYRKSTDLPEGPYDIFIVPPHSSGSGFIYLPSLQCHRNSFLAGVAATLVGVAVYVWVVPLMKTWVSTVAQSGDTSVFLIVIVVGVASWAWGRSQIHLSGTPPPPPRGSPRSPPSPPPPGGGGGPRGPQHEPPPSSGPNHNSGGGPHYQNFNSQYPGGGYGNGPNPGGQYNGGPFPGSQYPGGHRYTQGEGTPGSSESPPPPQPPPPPQSPPDPPPATPPKQPQNDTPKPKDTDWEKAREETKRKEDIRRKMEEFRKKREEEEKEKQRQREKEAREREFRERKEKREKERLAKEAEEKEAAEKAAKEKARQEAAARFAAAREAAAAKRAADKAAAEKLAAEKLAAEKLAEKLAAAKLMAEKLAAEKLAAEKLAAEKLAAEKRAESVKQAPSPKTPPRTPSPQKKPPPFPSARTELDDDAYSFRPYDRPKKQPSAPSVFSESSYAPSQSTARTTPPPSRRGPYSTKDPDKIIISGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUI6</accession>
    <name>A0A179TUI6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99525">
        <property type="protein sequence ID" value="OAS99525"/>
        <property type="gene ID" value="BDCG_00663"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00663"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="449" mass="49722" checksum="BE06FC6EDE46671F" modified="2016-09-07" version="1">MDSPGPKHRNAPIKAARPRSSTKGPLDAPDDTATTTLPTRPKSQHLPSRSSPSPTSPHPLLSTLSTIDIIPFPVNKNLSFLLRPDIYHPLSLLDISPAFRSEFPTPSPNEPLTTSLTTLDNLLNTGHFLLAAHFSATILSSSAIPHNDQNTIFSLLYIRLACLELTGNTLLAAQEAKALEDLNSAFYIVDTKLENETVAKDAFPADQARHIVPWSLRVLAARLQSIGFGDSRRGIAALYELGLEARKQLSRQGLIEDERNVWKTRLEDLGIRVVNSLIEMNDLDAARRSLANLKTPPKEQALATTRMALLYLKIGNVESARKLLDDTSVEAEGPLHCLLAMAEGRYADAVVGWEALRASHIGHEDEAIIAQNLAVCLLYTGKLNESRDLLESLVNNNHSFRSLTFNLATIYELCSENSRFLKFNLTERIASQPPSRYRNWEKPNADFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUJ4</accession>
    <name>A0A179TUJ4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-RNA splicing factor Srp2, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99533">
        <property type="protein sequence ID" value="OAS99533"/>
        <property type="gene ID" value="BDCG_00694"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00694"/>
    <dbReference type="OMA" id="HRMQISG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="300" mass="34714" checksum="D917E3E1387A3EE4" modified="2016-09-07" version="1">MTEVSSTRLYLGNLPRNVTKQEIEDHFNSHHGSGKITEIKLMSGFGFIEYEDAMDAKDVVPAFHGTDFKGERLTVQFARGPRHKETFSGPSDRSSAPRPRRTIYRMQISGLPETSWQDLKDFARQSGLDVVYSETGHDGRGFVEFETGSDLKTAVEKLDGREFKGSRVLCTQDIQSLEDRQSRDPYRSRSPGRRGGYHPYDDYDRRGAPRGGYSPRNHYRERSPGRRDYYDRDGYGRRTPPPRSRMDDYPPPPRRPYDDPYDPRGPPPPRHYDDPYAPRPYGRPRSPPPRGDYGYDRRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TV65</accession>
    <name>A0A179TV65_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_16262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99684">
        <property type="protein sequence ID" value="OAS99684"/>
        <property type="gene ID" value="BDCG_16262"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16262"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="99" mass="11602" checksum="9B3C03FB84063625" modified="2016-09-07" version="1">MMNKAAGLNTQRNDLRIERIERRSMMMMLLHLYATILSKSSNDAHDDRQYRRQNDGNTDNDARPQCLYDARPQCLYDARPQCLYDARPQCLRCQAPVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TV82</accession>
    <name>A0A179TV82_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626512.1"/>
    <dbReference type="EnsemblFungi" id="OAS99803">
        <property type="protein sequence ID" value="OAS99803"/>
        <property type="gene ID" value="BDCG_01328"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01328"/>
    <dbReference type="eggNOG" id="KOG4480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LTFESLW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="430" mass="47767" checksum="20FB64A7438A3404" modified="2016-09-07" version="1">MLDLKMLNKRFLPLSKDFRLRNYYTRKADLVDLSPLSAILYKGAMEDLSKEIFDAIRDHHTSFGSLVAKRVPLCLPPRTDTPALYAFGISRFAEIYFAFEEAWLSQLSQLPSVSSTSSPDEYEILDSFVNDDRGRIRSILSQLYIPELLRSEKLRSDLRALGWSSGTEDSGQDTPRDNYSSNNKDDDDDAYGNAATAFAAHIKSATAEHPHLIMVYAWIMYLILLNGGRRIRTKLAAGGHDFWKTNPESTEHGDGDSGIPNGLTFWFFHRDDKDLYDDEGIKQEFKARLHSASNLLSVSERAQIIVEAVNIFRHCSRIIAEIDVEVERAEIGKTVSGNGNGSSRSRSGSGIFPSIRAKLPTFASGILRRPSDSSSAQRRTRGGARLRPVLIGAAGLLGALCAWVWSMNADPAQGKYAFWKSGNETDGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TV84</accession>
    <name>A0A179TV84_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS maltose permease MalP, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_00202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99332">
        <property type="protein sequence ID" value="OAS99332"/>
        <property type="gene ID" value="BDCG_00202"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00202"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAS99332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="291" mass="32008" checksum="AD599D35BC754BE4" modified="2016-09-07" version="1">MFFSMGSPIGQVVGALAATYPMEWFGRKKTFAACVVLTAGCVFIQFFARSLKVLIVGELLGGLILGSYAVIAPAYASEVCPVALRGVLTAYVNLCFVIGQFIANGVSAATHGLDSHWAYSSPFATQWFWPAVILAGVFSAPESPWWLVRKGRLQDAENSLRRLASSSVDVKPTLSMIIETDRLEQQMEAGTSFRDCFKKTNLRRTQIAIGVYSIQVFSGIYLIGYSNYFFTQAGLPPDDAFNMGVSCDLRRQCQVDEFTWSFLGRFSRGGISGMHFILGSPRILRPPSDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVI6</accession>
    <name>A0A179TVI6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">R3H domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99814">
        <property type="protein sequence ID" value="OAS99814"/>
        <property type="gene ID" value="BDCG_01343"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01343"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="306"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="611" mass="66842" checksum="CB5F53BBDA89FDD9" modified="2016-09-07" version="1">MSNYHPQPQDMYHDNPSSRSPGSQRHHSHQQLHRQSSRQFDAYGPMTTGLYDDPMARYDSVRLDRLNPVLQGNSYAYDMSGSQTWNSNGFGTTNTLSGIGSGTGASTGRMKPTARGRTGLPATWLDQQPGLAGPFSLGPNSLQPMQNRSENLSPEGDDELIPTAIVIKNIPFAVKKEQLVQLMTEMNLPLPYAFNYHFDNGVFRGLAFANFTSAEETATVIEVLNHFELQGRKLRVEYKKMLPLQERERIEREKRERRGQLEEQHRPMPNSQLNSQPSLSSLTSHIPVTSPSPVSQRGAELINMNEPETLQYYSQLLLFKQDSSKEALIFPAKLSPLQRRTVHTLAHNMGLGHASRGTGDQRQVHVFRATDSNVSPQGPANPATVQTADTSRRGLNRAATIDFSEARGDGPGPFNTLRGHHSGFLSVLDSPSSFGNAQNLRAAKSFADLRSYTPSPVPSSASFPAALQSNGTRFQPFDGNTSAASNTPTLTPTPSGSSMAIQRDDNLLVNTLGGLSLGTGIGGPNSGSPRRLRGMFSWEQQDSQSSATAPIGSNRSIGLGFDSQPSQERIPMRQPRGPAPERGSGFRRQNGHQTRGSDELRSVSNVEIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVX1</accession>
    <name>A0A179TVX1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthase, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00016">
        <property type="protein sequence ID" value="OAT00016"/>
        <property type="gene ID" value="BDCG_01780"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01780"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="698" mass="78812" checksum="1D9FE847AC4278B3" modified="2016-09-07" version="1">MKLASFTGLRNLATWGVIRRVLWPNPQMTAKLIGIPMLLVKGSNRWTEILRALYLTDSGDNFMSLLLPECPPELITPWTKFAQFGLCWHDAAKNLDEQSRNSALTDLLQNLDQKNQNFQFKINELWFDAFKDFTGTVGITDPCTHFSKLFKNIVTTKRTADLTVEMNFEEYKLLRGDYGEERLIISLVASYARISEEEQNSISSFVDKGILALALLNDLYDYQKAFRNDSKGATLDRISNTVVFLMSTYSRSEDDAVRILKTEICALEDAALHEYDTWQLSAVQRSDELQFYAALIMAAAGGMAYWKATFETDPATSANDGDIPVSYSSKNCIPRPPQNGALTNAQWTTQDGHQLMDTNDFSGSITNVAKTASKLSGNKAQISVTAEIDVFQTFRRAPSETMCMAPFEYTISSPSKGNLSRLVEGLRAWIPGLREESVKVIETAAMMVYHNLLMVDDVQDGSQTRRGMPAAYILYGTNQTMNSATYVWVKIFELMAQLKFADACRDILIDELKSLGLGQSLELHWRFHKLCPPISDYFVMVDNKSGSFFQLVMRLMSAESGNPAAPDTKLSHFINLLGRYYQIWNDYQNLESSEYMAMKGFCDDLSEGKLSIILIHTLQNSVAKDRIKGLMFHREPGIELSDELKSYILSEMKAAGSLDFTKHVALQLYDAMLETLTELEATMGENKLLRYILHAWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TW88</accession>
    <name>A0A179TW88_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00174">
        <property type="protein sequence ID" value="OAT00174"/>
        <property type="gene ID" value="BDCG_02067"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02067"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="503" mass="56311" checksum="A474F752EF9C6E57" modified="2016-09-07" version="1">MAIRTRLWPSTPAILHSRTHGNGLCPFNSRTTNGQPLRFAEVVLPDHAGRSSNSLRRHNDSYYWKASCEHASELAPLTKRNLTKLTKRLANRGIYEPSSSTTPWGTTGEEYRSKTITKEFGDPRPYKRTPSPCPPSNAPISRGPEKLCPFSTTLTTHEPHQCTLGIACLLEVDDLNYHRYMATQIAAKAREARLSHVVIESGQGYHSLESLKATSKNSARLLLEKCKLHDLPRLDPMAVLKKIQSPEFWETERRYLENPGCLAKRQTRSVTTMPTSAFPLPSPEPITPEISQYMEQTWPPASIPPVHIGERDVHPNNTLHNPATQRSQMNEKKDAMLPEASNQIGDQMNAHGKRKLVKEARVTGNFSSKHSGNPNTSTSRDGSQSDSSHLPNPTTTQRSTRRNMQQTSGPSNLSRTTKVKRMSHDQQQPASSCKPPVNKPRAEGVSTMPRSQIMHTNPLRSARLSKTDNVGRQTEREHNPAVALGTMKHSNFKKRKIFSKDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TW94</accession>
    <name>A0A179TW94_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 3, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00085">
        <property type="protein sequence ID" value="OAT00085"/>
        <property type="gene ID" value="BDCG_01882"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01882"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="PTHR13048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="137" mass="15516" checksum="35CA04B79279AF11" modified="2016-09-07" version="1">MGYNIGMRLIEDFLAKSGTGRCANFRETADMISKVGFKIFLNITPTITNWTSDNKSFSLIFEENPLADFVELPDDGRAQDELWFSNILCGVLRGALEMVQMQVEAHFVSDVLRGNDATEMRVSLVRYLEDELPPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWK9</accession>
    <name>A0A179TWK9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_16135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">ER-3</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99438">
        <property type="protein sequence ID" value="OAS99438"/>
        <property type="gene ID" value="BDCG_16135"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99439">
        <property type="protein sequence ID" value="OAS99439"/>
        <property type="gene ID" value="BDCG_16135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16135"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="57" mass="6619" checksum="21787ACFA2C6B3E7" modified="2016-09-07" version="1">MYVFQWGHCHGNGSKLRLGWNHTELFFGPELATNVQLYLDLDTYSPRYLLLKGTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWL0</accession>
    <name>A0A179TWL0_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase 2</fullName>
            <shortName evidence="11">MAP 2</shortName>
            <shortName evidence="11">MetAP 2</shortName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDCG_02379</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="function">
        <text evidence="11 12">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11 12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11 12">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00294">
        <property type="protein sequence ID" value="OAT00294"/>
        <property type="gene ID" value="BDCG_02379"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02379"/>
    <dbReference type="OMA" id="NEIAAHY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="14">
        <location>
            <begin position="124"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAT00294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="443" mass="48810" checksum="8B20932DF7C82820" modified="2016-09-07" version="1">MAAQVTPELANLNSKPEGGAPPKQVPVKDVPENEDVESDDDNEGDQGAGEPGTAKKKKKKKPKKKKKGGPKVQTEPPRVILSSIFPNNDYPVGELVEYKDDNAYRTTNEEKRYLDRMNNDFLSEYRYAAEVHRQVRQYAQKTIKPGQTLTEIAEGIEDSVRALTGHDGLTEGDNLLGGIAFPTGVNLNHCAAHYSPNAGNKMVLQYEDVMKVDFGVHINGRIVDSAFTVAFDPVYDNLLAAVKDATNTGIREAGIDVRMSDIGAAIQETMESYEVEIKGTTYPVKPIRNLNGHTIGQFEIHGGKNGKSVPIVKGGDQSKMEEGEVYAIETFGSTGRGYVRDDMETSHYAKVPDAPNVPLRLSSAKNLLNVITKNFGTLPFCRRYLDRLGQDKYLLGLNNLVANGIVDAYPPLCDIKGSYTAQFEHTILLRPNIKEVISRGYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWM5</accession>
    <name>A0A179TWM5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99949">
        <property type="protein sequence ID" value="OAS99949"/>
        <property type="gene ID" value="BDCG_01641"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01641"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="100" mass="10906" checksum="A790804F0ADF76BC" modified="2016-09-07" version="1">MCKRPSDDNIYFTKEYSFNTNRASVSFCQISVIRLAAMDFLHGKERMIKAASAIRLQGIETVQPTRPHASLHGKVSAAPLGLQHCNAPSPKDAPSHGPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWN1</accession>
    <name>A0A179TWN1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_01424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99852">
        <property type="protein sequence ID" value="OAS99852"/>
        <property type="gene ID" value="BDCG_01424"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01424"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="156"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="273"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="378"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAS99852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="501" mass="55984" checksum="9E39A2EC5A38C76D" modified="2016-09-07" version="1">MVHVAFDTRHSKSKGFAYVQYADPEAAIQAFKTLDGKVFQGRLLHILPASSKKTYKLDEYELSKLPLKKQQQIKRKQEAASSNFSWNSLYMNADAVMSSVSERLGISKSELLDPTSSDAAVKQAHAETHVIQETKAYFSSHGVNLDSFKKRERGNTAILVKNFSFGVKADDLRQLFEPFGQIKRLLMPPSGTIAIVEFVMADECQKAFKGLAYRKLGDSILFLERAPKDLFDENATATRVIAPPPKVISQTYSTSDIFKATETEEAESPLETSTLFVRNLNFSTTNARLTEVFQPLDGFLSARVKTKTDPKRPGETLSMGFGFVEFRSSAQARAALAAMQGYKLDQHELVIKASHKAVDAAEERRRQDNAKKLAMRGTKILIKNLPFQATKKDIRNLFSAYGKLRSVRVPQKFDGTARGFAFADFVSAREAENAMDALKNTHLLGRRLVLDFASEEAIDPEKEIQNIEKKMDAQVNLVNLKNLTGSGRKKFNVDAGEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXM2</accession>
    <name>A0A179TXM2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glycerophosphoryl diester phosphodiesterase, variant 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Glycerophosphoryl diester phosphodiesterase, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_02388</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ER-3</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622729.1"/>
    <dbReference type="EnsemblFungi" id="OAT00299">
        <property type="protein sequence ID" value="OAT00299"/>
        <property type="gene ID" value="BDCG_02388"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00300">
        <property type="protein sequence ID" value="OAT00300"/>
        <property type="gene ID" value="BDCG_02388"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00301">
        <property type="protein sequence ID" value="OAT00301"/>
        <property type="gene ID" value="BDCG_02388"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02388"/>
    <dbReference type="eggNOG" id="KOG2258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="58"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="368" mass="41299" checksum="9989C255943695DA" modified="2016-09-07" version="1">MDAETPLLENVMTTLGYSLEEDDRPISPSSMSPEKAGYFPKAQWANLDRGKDAPRSNPIAIAHRGSKAKFPENSMSAFIHAISAGAQVIETDLHLSRDGEIVLSHDATLQRCFGVEKRVIDCDWQYLSSLRTIREPFDPMPRLVDLLRYISSAPERKHVRLLLDIKLDNPAQKIMRALADLLRSTAIRPEHKPWNERIILGCWTAKYLILSHTHLPTYPVCLISFSLSYARQFLRLRVPHVIFNLKLEALMGPGGARFLADAQAAGQHVFAWTVNEEALMRWCVRHGLDGVVTDDVEVLRRVCEGERARCYGEGIGRGDGITMRQRVNVFVTAVVLYLAGSVFAAVYPVDLKEFIGGLYQGIEKVDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXN2</accession>
    <name>A0A179TXN2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00213">
        <property type="protein sequence ID" value="OAT00213"/>
        <property type="gene ID" value="BDCG_02205"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02205"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="242" mass="27203" checksum="FFBAF1979655A0F8" modified="2016-09-07" version="1">MTDTSHDSDEPRSHPKNNSQAHENSPQSNHSGADSTSLDSTSRDGAHPQAKPSTQDRVRVAYTEYLHDDTKERHKGKIYREYAYGDRGFPGLIPPGATLILDERSSLCGEFTFILRSSELLMCSGSAGVGPAARTANHMSLSSVNSSKLCLEKRKPTPGKLYWRQYDQQHYKILSSECYHQPRSSATLLQNSFDSVLPRFPFTDSVITAERNLLVMDWFNPFKTTSYGPSFMTAERNERMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXN4</accession>
    <name>A0A179TXN4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_03085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00575">
        <property type="protein sequence ID" value="OAT00575"/>
        <property type="gene ID" value="BDCG_03085"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03085"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT00575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="521" mass="56606" checksum="971ECAF50FB68DB2" modified="2016-09-07" version="1">MATIQDDDERLLARIGYKQELRREFSKWSTVSYAISILGVLGSVPATFGPPLAAGGPATAVWCWFIGSFMAMCIASSVAELVSAYPTAGGMYFVTKHVVPPNQVAIFSWIQGWCNLLGQTAGVSSVAYTVSQMLLACASMNSSLEGGEYSYSPNAHQTVLLSIALLCVMGTVCSLSTKSLHKIVLWFAPVNIIASIAICIALLILTPDKQSAKWVFTNVTDGSGWNSKTFSFLLGFISVAWTMTDYDGTTHMSEETHDAAIRGPIAIQLAIVVSGVFGWMLTVTMCFCLSDLDKILDSPTGLPAAQIFLNAGGRTGGTIMFSFSILVQFFTGCSAMLADTRMAYAFARDDALPFSKFFAKVNPYTLTPVNAVWFVVFFSICLNCIAIGSTETATAIFNITAPALDLSYIAVILAHQIYKNQVQFIEGPFTLGKWGTPLNIISIVWVLFISVVLFFPPTRPITPKNMNYAICVAAFIALFALSWWWLSARRKYTGPRTKDLLQAVETEDLDVPYGTTAGFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXN6</accession>
    <name>A0A179TXN6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99797">
        <property type="protein sequence ID" value="OAS99797"/>
        <property type="gene ID" value="BDCG_01313"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01313"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="174" mass="19001" checksum="AC13FF873F7E07D6" modified="2016-09-07" version="1">MWNLLAFDTISVYVRRSTRNRTISTVFTYHPPFPPPPPPGALRTCLPSNKALIGDSQTNMPATAGLNAAIYKGTRTPASPRTGCSSSSTGPARQRSSFSRPTAGCAGNYRFFEMEKKPRRLQAAESLGDGPPVRRGRGYHRDQRDCRRLPKLRLPPPVMDTLGGIAVGTLCLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXP6</accession>
    <name>A0A179TXP6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99400">
        <property type="protein sequence ID" value="OAS99400"/>
        <property type="gene ID" value="BDCG_00356"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00356"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="629" mass="70308" checksum="DB7310AE2AD1E21C" modified="2016-09-07" version="1">MRKAIATGTGQGDGSDISTPLGNSNRLRASCAPQHVPPSAAARSASSKPQGGTNKSFEFVLVTDSESRKQVRRHAMRQYMRQRRLDGIARLESSRAQVRSWNAGNTSASATLLSPASSRIESLDKNEKTVDTKNTPSDWSRDRVVSTELHTPKLDDDDNMTNDTDEHMSTFLQEIHSSNLNVVPGSGYLDPFSSYPLKLTRPDQNLIHHFVTTYPMMMYKMGDAYQDNPIKGIFHHLTLHDPVPFQAMLAISSKHLTGAAGQNESVQSLTHKMRALRLLNERLQSDVGGKYDGTIYAAATMAVIEKWSKDPAVERMHHQGIRQIVRRRGGMCGVRASSPFLESVLYWVDFSSAPRAIVGASLPWTGDIPDTVPSSLPYLSSELHIPLTPLHHSMGTDPEEISSALRACEDFLTFFCSLDELQLSLITSAVPPSQSFHHQGQDFQRPRLNLFDPSTPLYSILTTLPDYDHGIRDIRFIDEYSCMACLLYLNIAFISSLLWVFLGHGGYMANEPADKGERSWFVSRMLRVAKKLEWKRGGTSWDNLRSTLLGFLTTHVECGIGSYQITEAETLARQNRPSLRWDEDEMRRDILGPLYTGPPVFSMDPNPENMNHTLLPLTAPDYEPSSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXP7</accession>
    <name>A0A179TXP7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-repair protein complementing XP-A cells, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_01366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99828">
        <property type="protein sequence ID" value="OAS99828"/>
        <property type="gene ID" value="BDCG_01366"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01366"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="PTHR10142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA_C" evidence="6">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAS99828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="350" mass="39891" checksum="8A0B273202A7381C" modified="2016-09-07" version="1">MEAHQNKGPSSPRGNSLVSNTQTLLTPEQLHRIEIHRMKAKAIREQHDAEARSNSMFSGSVTAGQKRPYSDISLSKPPISSRNARSNKSYDRPLDEIRPARNFAKYVEYDMSKMTDTKGGFLTAEDDPHNKVLNSGEGDEKPAHMTSREWERHQLLQSLRRDKAGPFEPGLSILKTLKCAVCNSCKEKFPEKYSLLTKTEAKEDYLLTDPELKDEELLPHLEKPNPHKATWNNMMLYLRFQVEEYAFSPKKWGSPEALDAEFEKREATKKRQREAKFKSKLHDLKKRTRVEAYRRSRQAATGEGSGGDFGDDLGSGKHVHQWGRLVDNPETGIGVKTCIDCGMEIEELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY02</accession>
    <name>A0A179TY02_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_03601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00794">
        <property type="protein sequence ID" value="OAT00794"/>
        <property type="gene ID" value="BDCG_03601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03601"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="104" mass="11327" checksum="67290AF5B076D696" modified="2016-09-07" version="1">MVSTAGTELAAIATTSFTVSTTYITCQRITTRKQQSENCIPPRALNAEDVGVGTNAANAIQNSRIEISRTSSRMSVGPVHDIQAVPVPRPQGVYVYTVYLRQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY04</accession>
    <name>A0A179TY04_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoserine phosphatase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_03505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00746">
        <property type="protein sequence ID" value="OAT00746"/>
        <property type="gene ID" value="BDCG_03505"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03505"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="227" mass="25428" checksum="791A521E8DA0EBCC" modified="2016-09-07" version="1">MAPSLSKITDNLGYGLEKRRQGNIDVLEDKITFRDSFREMLDSVKTPFNECIRILLENMELDPHFTEFYNWARDNNVPIVILSSGMVPVIHALLVKLLGHEPDNIQIVANQVASRDGKDINSEGGWQIVYHDDSHFGHDKSIEIKPYAALPAGERPTLLYAGDGVSDLSAASQTDLLFAKKGKDLVTYCQREKIPYTLFEDWSTILQTTRDIYEGKTDPKSVAAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY05</accession>
    <name>A0A179TY05_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00343">
        <property type="protein sequence ID" value="OAT00343"/>
        <property type="gene ID" value="BDCG_02487"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02487"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="119" mass="13299" checksum="28BEE8861842DEA4" modified="2016-09-07" version="1">MTHVHLSAIAKIAKKRLEPTTRPNCKSAEGLGGNSAGQDEGPLCENGSGVMLYQEFYDTLRQFYCPLLLPTVDFGYLRLLIFSGDVWLSERMETLVGVGKHFAIEYIYHSGKIFQSPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY06</accession>
    <name>A0A179TY06_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_03416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ER-3</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00705">
        <property type="protein sequence ID" value="OAT00705"/>
        <property type="gene ID" value="BDCG_03416"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00706">
        <property type="protein sequence ID" value="OAT00706"/>
        <property type="gene ID" value="BDCG_03416"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03416"/>
    <dbReference type="eggNOG" id="ENOG502T1RK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="847"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1412" mass="157113" checksum="EBDD053684D964BD" modified="2016-09-07" version="1">MTSNPLGPLGECRTMGEDLFSVNLPSDEAGLSPTSKKILEKCAIPVTPVSLNSCFQITPTLISRPPNSDLETGEFNFHFAKPKLPTPNFTSRLKAKPAGSILASASNQKVIVNPSGTNCPDSNCTESSSSGTSALSKDSAINSGQVSPTKSPITHDTAERTCGPTAGIHRSSKETGHSLEIGDRADSQSENDALEKDSNLATNHTQSAQSPNQDPTGPIPNTDNCNSPASARSHSGNPKLTPPRPSAMKATPQPKLMVNSKVTKHPMSAKSVVNGVATKQVTLQKGSSSAFQPSEEDLFYMLIRKLKKRDEMEAEATAMKERMKDEMLALTRTNDDLRSRLRESQISGKSQQERLNASNSLVERWKTKFSKLRTFVTSVGSDFESLRKEGQILKSTQESLLQEKNQIHETLKQMSDSTGSLKTRWSQHRATIVGVRQEFNTLEKSLLTATTRVTETEKLLSRERNHVATLENYIKNHSDRHHKQALDIDERQSQMIKKIDTIHKHIESWNSAQSSIKDELESGFTSCMSLLKSLSQQQTLKPQDLEKVDCAIRDLSMQLHVSIEASKKNMEVAFDLHTNYGQRVSSQLTGLETAVKSNTEVVCQLAEARELHGNLQEKLNAADKSLHMVSADRDRLKSQEASLQRRIRDLEIEISSLQKNKIEDAQFRDADMSSELQIQLEATSASLTEVSNELKEKQSEISDLELKLTDTIERLAAAESEIAGLTSERLKIRDEAQKTEHRVREELTRANLAAKDQHRAWFEQERHKLKREKILAEKSAQKVAEELNSVKISLEAAEKGNHELVAKMSQQQSEIDSLKMTASKRDSNIAAEMDEVNMLHASTIQELQSAQWQLEAATKEKEELRHQLSELRMNLATLQEQEPLQETVEVLQYEIAEKDINLLSLKEELSKSEENNKTISQLQQEVADKSAEIAILRERLDNQLTSVTTIGESLKEKNNELIILEQKMEAFGKLSAETSALKRDIEQRDNELAELRSRVQESNVIFKNTESILRQLGIIGTMESLRDYSNVLQSRLKMMAGSLDGRQPKEPIESGLHIPMRISSKRQRTSRKRSMSSTHAECARPGSSSRERQTTEIVYRTRSTREIISPTLKTPSRGKNANSGLPTTSTSFIRPFSRLQNETTPAIYPGEQMSPVLEFTDLNALFPTTPMNAKNVGSNQARMAAAQNSLPSDKVILPCEVARTKERSALCVSDAVNDAICTSRRDKECEQSRGSIEAEAPHEATGNEPAAAASTPNKCRIDNNLEVQDNPCSPPKTIARTLKRKKMSEDEMHTMKVASQKSPEKLPRTGILKDTTKPTSSTIETVVETPPHENSGETPMGASPKITFRRPSRKSKYFNPTNSPAASITAMGGRCGSTTKKSHPPAGRVRERPRRRQRGDLYHNRFSQKPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY11</accession>
    <name>A0A179TY11_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CFEM domain-containing protein, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_02785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00430">
        <property type="protein sequence ID" value="OAT00430"/>
        <property type="gene ID" value="BDCG_02785"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02785"/>
    <dbReference type="OMA" id="ANSTCEV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="392" mass="43196" checksum="0EA0629870DBFB01" modified="2016-09-07" version="1">MAVENCVLGHCTFREALTAKRISENLCGHSERDRTSLVSICGVTGLAVAFTAFILRMISKAPYFGGQFHADDWTITVAMVFGIPLGVLSVPLANAGLGKDMWNVQFDKITYILKVYYVQEVMYFVTMNVTKVSILFFYLRIFPSHKFKIACYVVMSVTIAYGTALVFAALFQCNPVHLAWEHWDGEHTNYKCSNINLIGWLSAAINIVLDIVIITLPVKQLLGLSLSVKKKIHILLMFGVGFFVTIVSIIRLKSLLQFGNSHNITWDHVPVGYWSTIEGHASILCACMPAIRALLRKLFPAMFGDRTGASSSGTRKIRTNKLSSSNVKIFSSQGHVPHSPLSPRSPHARNSLGKGGGTVSLESDIFPLVERGEVGPGHGFGSYTIVKSVYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY19</accession>
    <name>A0A179TY19_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99746">
        <property type="protein sequence ID" value="OAS99746"/>
        <property type="gene ID" value="BDCG_01164"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01164"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP2" evidence="3">
        <location>
            <begin position="164"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="718" mass="78537" checksum="3BCC1CDDD5217A12" modified="2016-09-07" version="1">MDSEENKGTEQTSKGLPDHWRFTPSIMDPNSYAFTSLANQPSTYYTATPTGMGMPCHTQVPDLSTPGMTLNLLSPLSIPPSTSATDAAAMQSAIDMNSFHHSFAPQAGNGVDSFHHAPAYAPSSFVNRDPRYNPLHVENSPINGVNANNHIGLLPHGIGLSTPVDNRPNPGSENFRFNVTLKAATAMVKDPDEIPITYLNKGQAYTMSVLDTGPMTSGAQPLKYRTFIRVSFEDDEQRSKPASCWQLWKEGRGSNEAHHRDGKLLAVEHVDPNQGGDGDIRPSQVHLETANFDGFSVIWSPNPNGNPCCSISVRFNFLSTDFSHSKGVKGIPVRLCAKTEVISTGHGNPPLEDRPEVCYCKVKLFRDHGAERKLSNDVAHVKKLIDKLKQQISQAELGSGFNRRKRSGSFVKGKITKHKRAWSGESSNDSGKSTLEEDLQIKLRTLKDMFSSTRPFSALNLKGDAHDDPDLFPVHLGITDEGFSHSIGWESRNNAEGSSIASQHVLSPATSNHSLSSSHNSFDPNTGFPHQPQVYDGSRHDSMDWSSISQQDSDSQQQIRNGRFLSHPVKIQKVSAGGRAGHDGWIEAMDVDATYQPPLAAPKKPTSCFYVQIRQSCGNQVPDGYYHAVYLTQRTAKDLVHVISKKCKIDASRVVRALCLRGNGLHVILDDDIVNELPEGQDMAAEISEVRDCSLDASTNGDSSTPSTSSGIEVKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYQ9</accession>
    <name>A0A179TYQ9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BDCG_00061</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99271">
        <property type="protein sequence ID" value="OAS99271"/>
        <property type="gene ID" value="BDCG_00061"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00061"/>
    <dbReference type="OMA" id="SMTQNQT"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="SSF54160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="181"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAS99271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="469" mass="54014" checksum="97F1B3169E35E7E7" modified="2016-09-07" version="1">MRQRKGGSSFYVHYVDFNKRLDEWVPASRIDLTQEVEWPQPEKPEKKKVSGAAATKAQPKNAPKRPRGDSQGISSTPDLLAGKNLNISKASRASKAGGKENREDETPLNLSLLGSEVVSSVGTPRLDGESEDIEMLDAVDVDAKQAIKQEEDKLAAQIAKEEEIEKLRTGGSMTQNPTEIHRVRNLTHIQMGKFEIEPWYFSPYPTHFTDADMVYIDEFCLSYFDQKRSFERHRTKCTLVHPPGNEIYRDDHVSFFEVDGRRQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYCMTTRDEHGCHLVGYFSKEKESAEGYNVACILTLPQYQRRGFGRLLIAFSYELSKRENKLGSPEKPLSDLGLLGYRQYWRETIVDILMEPGRESISESELASLSAMTEKDVHETLVVLNLLRYNRGNWIIVLTDAVIEQHKKRLEKEKIKGARKIDPARLQWKPPVFTASSRTWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYR7</accession>
    <name>A0A179TYR7_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide hydrolase</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_03125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002627759.1"/>
    <dbReference type="EnsemblFungi" id="OAT00593">
        <property type="protein sequence ID" value="OAT00593"/>
        <property type="gene ID" value="BDCG_03125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03125"/>
    <dbReference type="OMA" id="AFTAEWM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="PTHR12283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007950365" description="Peptide hydrolase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="6">
        <location>
            <begin position="125"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT00593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="376" mass="42221" checksum="57CB1CA8E6E0ED16" modified="2016-09-07" version="1">MAESIHRLATSWLIFLLGTLFFAIPVQSYATLSDGTLKSIPRPNNDFDIHNGALLAPILKPRVPGTPGSLEVLQHFVDFFRNTLPEWTIEFQNSTSKTPVTGNKDIPFVNLIAYRDPPWSNIGETSRLTLAAHYDSKLEPAGFIGATDSAAPCAIIMHSVRSIDAALTKKWDAMKGNPSHESLLDHRGIQVLLLDGEEAFASWTDTDSLYGSRSLAEAMEETFYPATSTYKSPLSAISLFVLLDLLGEKDPRMPSYFKTTHWAYKNMASLETRLRQLGQFKSAPSWKNGDQLWFVDSEKERFFPSGIGDDHIPFMKRGVEILHLITSPFPKVWHKITDDAKHLDLETVEDWSTLLTAFVAEWLELEDMLPKHEGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYR8</accession>
    <name>A0A179TYR8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF7 family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99770">
        <property type="protein sequence ID" value="OAS99770"/>
        <property type="gene ID" value="BDCG_01229"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01229"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="PTHR22761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="396" mass="43863" checksum="7897307C96369760" modified="2016-09-07" version="1">MGPPGSITDYHSIRCNSMIPLDAFQTSSTSPFKTSWIRLPPPPTISQVMGWSMKQLRAFLFDSEGHSGGSGNLQVMNLVLVDNLKEVGKRIVATASSSHRSNTDLIYSKELFTKRFANIGGGAVLSNLDVDVLLTFLSRDENAILYDGETVKFKSAKNNVNSITHEDRTIASLKTLISNLIGQVALLESKIKESSLRAKDAVTNKNRVVALSALRSKKMAENNLKQRTDTLLQLEEVYMKLEQAADQIDIVRVMEASAGALRSLHAQVGGVERVEDVLEELREEMSKVDEVGNIINEAGEAVDEDELDDELASMEKQEREARDAEEAEATQRKLAELERFEKSAIEAEARRKAEKENATVVDYDSELDDSIGKLSNMSIEDRENTEAQKAEQVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ06</accession>
    <name>A0A179TZ06_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2183 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99361">
        <property type="protein sequence ID" value="OAS99361"/>
        <property type="gene ID" value="BDCG_00260"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00260"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="DUF2183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2183" evidence="1">
        <location>
            <begin position="239"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="397" mass="45107" checksum="0F0CED0D98C951EE" modified="2016-09-07" version="1">MFPTAQDLRQSVNTSETFLQHVATEVLTISPYGNWTDQGWSLRFRGSVYKQPNIADRMLHTLASMFLLGASIKKLPPANYAHSLNMTRSVFILKQSHTKVSFHVTPDTSLDAHSEDTLLWTEGQDIEVPGVTNMEGDFDSFIEIKNVSGAFPIPGNETRKTQRLKLHAYGTDTGNATAYLIPPEGLTLISDIDDVLRVSKIFSIREGLNNLFGRPFVPWMNMPEIYANWSRSLPDLHYHYLTTTPEQLTRPYMDYIFKTYPTGTFDTRIVNFTDLGATLSIREFLLDKVFQTFPKRKFIIVGDTTNLDIMSSYPQLVTKYPGQVQCILLRNTSASDSSNRVPYNTKWFKGLDQQMYMFFRVPDDLKGLAIEDGRCYNASIPQNVTFGWQGLPFGSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ09</accession>
    <name>A0A179TZ09_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01144">
        <property type="protein sequence ID" value="OAT01144"/>
        <property type="gene ID" value="BDCG_04418"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04418"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1357" mass="151361" checksum="A55B29DEE9B96C2A" modified="2016-09-07" version="1">MTTLLYESAFTSEPTEASGYRTEAQTSGSSRDPEWSPQGSLASFICHASHLQKALRTDDSIFVDDNNGIKALSRQKIGSGASFIVERAEWIAGVHENDVSLSRQFSKWGKYIAIKSVRERPNSSRNNWSDVSLELRALLHKPLRYHPNIVHLLGFGWGSSAESDSAYPKVIIEYATFGSFHDLQVYRPPLHFAIKQKLCHDIARGLAILHACGIVHGDLKHENVLIFVNKYDIPKGQPYTAKLADFGGAVMDIDQRDLSYLSMGTYPCQAPESSNRLSADGIKQTDVYSFGLLVWRAFIDGRNIATELGLDSNPTESSERLLQQLKLNNDILLKAVCSTQVYASDHGINENALALILYVLLQTIVVDPMDRSLPRAQAALRGMHFSKIDSFLQGVAAANDEGDRIESMEAPGSHGLTVDNLGFFLGNLGSDYDCQRNTPGHRPKISPPDIAEFLFEPDKLRTILDWTQQQQIVSDFKEACQKTRPGTPDGLQPWKAAYYLFQCNLTGFGVTFDEKQACRWLHESANVDDKGDVDYWAMAWLWRVSTALSVPPSLTLDQLQEYIRWGIIRGHHNCMEDAREIIARLTSIDERERWEMMLTEADWARRTIAGGVGMPHFVPRKLRRCYNLNDTVILEDQIKDELGTAYNSCLRKKGSHSSATKNAESPQVEKSEFDKIFVNHKGHGLLHLAATLGKLKALKYMVETYLCCIDLPNKSMAESPLVCACRSGHFDCAMYLLDRGANGGGTEFGEEVPLHWLCSFTPEKMTPLALALVDAGANIEHATGTMRKDVRMINADWEDNFGIPTTPLGRAVLMRSLPAVKVMLGLGANPLAKVGHKDNITVKSPTELAAVLTLPHILEVLLLYIDQMLPEKKPIFDEIGMLQAAHGRCITPYDPTTLQSRLVRCGSRYKRDMFQTLQILRRRHEKLRDWRTLDFGKPVEGMQLCQEVRLGNADIVEALLELGQDPNGSPDHRPIEEAVLMNHEAIFRLLVNRGAGTGVKRTVGNGRQFSLLQLSASRPRTSRNGIFVAEYLIRSGMAIEPLPDGSPSSVALAIKNRYFDLSDLLVEKGADINALYQFDKREEWITVLGELLLTHTEATLQSVDYILRKLNVNSNNPAGQVEFIVNKTQKLSALHLLALCPSNALNDRSQISARVIQAVLAAFHTTECINYVHPVLGTALCIASITGHLEMVVALLAHKADAEITMRVDQLSEKHIQDLGLPSTWSNREFQIGESTPLLLAQFAFEVHLSELEKSSSFEISSLSKLDCFEAMVPLFQSAGISDSNAAWISLRNRRKLLEDRIGLCTSMAQLSQIDLSEPVDLSVLTDEKPTNWEEGDEMNQEMATRTMLKFMRGGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ12</accession>
    <name>A0A179TZ12_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00278">
        <property type="protein sequence ID" value="OAT00278"/>
        <property type="gene ID" value="BDCG_02361"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02361"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="513" mass="54918" checksum="1E56B1568017CAD7" modified="2016-09-07" version="1">MVKTRRVVDPSANSEAMFADPSDFMAVAKVHNASCPSDPPKPTRNAAAQPMTPSNQTKQENAAKEEVCIQEGASHNGVLEEHIKGGTQKRKNEDTISATLANDLQLKGTILPEHDAKSTSGNTWAIQVDSLPSGGIGPGQTDFGKLKTDKRFRSSLPQPIHASEESTLLIDLMRKSRSPSNPASAIRPRHMDSGNIAPMSSFLTNTPPSMRMLLPEIPTSSAGAKAVGNSQNGTSNAALKAALDLLIDRLQRELHQVNQIIEDTPGPIELTGIGIYLLKRKQQLESEIAEAIEMESDIVLPFSALTLEDPSHKEPNEEHNVSQEMPIPKVPVVSMDKKEVAPLIPGSGSTAMSFGKPNVGPQEVLLMSNNTPPIPTPTLSTFTNSVHDIIGDHLLPGRNPSSIKSDLETPKVLSGNSSLHDFSTPPAGPATGEARPAPHGAVAFDHSSSVNQLQVRDTPNIPDNAITRQYLESTSETTVIKFCNSSPGAKQRTALSHLLHDCSSTIPCRTIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ18</accession>
    <name>A0A179TZ18_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDCG_00277</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99371">
        <property type="protein sequence ID" value="OAS99371"/>
        <property type="gene ID" value="BDCG_00277"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00277"/>
    <dbReference type="OMA" id="YHPICRQ"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="PTHR45726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Leuk-A4-hydro_C" evidence="15">
        <location>
            <begin position="468"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="270"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="568"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAS99371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="616" mass="69298" checksum="61C9EADBECBA6BB6" modified="2016-09-07" version="1">MDATINPLRDPNTLSNYSAFRTTHTTVNFNILFDKQQLTGNVIHQLKSLNGEAREVILDSSFLNIRDVKVDGAQNKFELLPRQEPYGSALKIPLAEGVAMGKTVDIDIAVETTESCTALQWLTPAQTSTQKHPYMFTQCQAIHARSIFPCQDTPDVKAVIDFNISSPLPVIASGVPVRDGSSSSSESSNKVYKFHQKVPIPAYLFAIASGEIAEAPIGPRSRVAASPDMLEGSKWELEADTEKFIQAIDKIIFPYIWGEYNVLILPPSFPYGGMENPIFTFATPSLISGDRQNIDVIAHELAHSWSGNLVTNASWEHFWLNEGWTTYLERRILAAVHGEPYRHFSAIIGWKSLTESVERFGNDHEFTKLIVDLKGKDPDDAFSSIPYEKGFIFLFYLENLIGKAKFDKFIPHYFTKYKELSLDSYEFKSSMLDFFSNDSEDHALLASLDWDTWFYSPGLPPKPDFDTSLVDIVYDLAEKWRTAPESEFVPTAADVKGLSANQLVVFLEQLISFEKPLSAEQSRLMGDIYGLGKSRNSEVLNLYFQVGLKAGDKAVVEPTAVLLASIGRMKMVRPLYRALEKFDRNIALEIFEKNKNFYHPICRGLLKKDLFGDKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ37</accession>
    <name>A0A179TZ37_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ER-3</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99390">
        <property type="protein sequence ID" value="OAS99390"/>
        <property type="gene ID" value="BDCG_00342"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99391">
        <property type="protein sequence ID" value="OAS99391"/>
        <property type="gene ID" value="BDCG_00342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00342"/>
    <dbReference type="eggNOG" id="ENOG502SQYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="SSF57959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="259" mass="28700" checksum="FEC1E13BF3769459" modified="2016-09-07" version="1">MSTLSAVMNRSAAYPYTPSQPAPQSRFNSSHGTSSAFSASAHPNEDWTKISDLAERRRIQNRIAQRNYRKKLKRRLEDLERRATSSSASPEQSHKELSLPATSKSKKSKSPSRRAATIEKAKAKDDQKAPTKMVLTQPLSSYQGEQRASMFSDPSTRQLSASPPLAFATHYQACSPNYSYPQYPQESTYHPAPIPTSELPPSGYYIQPLSSHPPPAQELVYPEDDLLTPFGMNYASMAGFDIPATSAPYQDPNSLVSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZQ1</accession>
    <name>A0A179TZQ1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_02928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">ER-3</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00508">
        <property type="protein sequence ID" value="OAT00508"/>
        <property type="gene ID" value="BDCG_02928"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00509">
        <property type="protein sequence ID" value="OAT00509"/>
        <property type="gene ID" value="BDCG_02928"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02928"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase_Ca-bi" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT00509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="642" mass="74330" checksum="7FF589D2E6626198" modified="2016-09-07" version="1">MKSLLDQEDTDKNLQITILDNGPKVISLGTLLSDGGRTREIRGTYLLANLLEELHLTKGKHASKLIHFSDVSEDPVSRINRKIKDEYWNNLTRRLDESMIEAAAPDPKDWNENPRPRIFVPYGEGRLYDYYCQVSKNKPELKLEVQYLPQGEVTAEFVHGLRDRPGLLALEMDYSNPDKLRGLQFIVPGGRFNECYYWDSYFACLGLLEIGRIDLVRDILNNFIFQVKHYGKIPNANRSYYLCRSQPPFLSDLAVRTFQGMNNKEEAAEVLRSGILAAIKEYFTVWMSEPRYDPTTGLSRFKPPGKGIPLEVEEGHFDAVLYSYAEKYTCTIPEFINQYNSGNVNEPELDEYFMHDRGVRESGHDTSYRFDQGCADLATVDLNCLLYKYETDITWAIKTVFNDKLPIPAEWRTTDMGDDHVETSASWLQRANQRQERANKYLWDPEQGMYFDYNTRTHKRTTYEYVTTLYPLWCGIASREQAESLLARALPKFECVGGLSTSTEQSRGPVSMPHRPPKQWDFPFGWAPHQMLAWDGLKRYGYLHEMERLVYRWLQLMVRVAVNYHGAIVEKYDVTQLDNPSQVDAEYGNQGLDFKYANIEGFGWSNASFSYGLSLIKHQKLMVKALGLCVPYDDLRMERVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZQ2</accession>
    <name>A0A179TZQ2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00111">
        <property type="protein sequence ID" value="OAT00111"/>
        <property type="gene ID" value="BDCG_01910"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01910"/>
    <dbReference type="OMA" id="ASWRWTC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="451" mass="49195" checksum="818DB25701B311D9" modified="2016-09-07" version="1">MKWTTTALMGAYCFLPPFASTIFAPALLLVMADLGIKNPTLGAIQVSIFVLAFALGPIFAAPLSEIYGRTIIVRTCNILFITFSLGSGFAQNAAQLTVCRFFAGVGGSGGLAVFGGVLADIWDLKERAKASALMSTLLILGPVAGPACGGWISERESWRWTCWVPAMAATALEVISLVYMKESYFPVLLERKLLRNKRLYPDRDLYTVIELRPNTLSAHRVGWFVSSAIRPVIYLLVDPALFLLSLYFAFVFGEVYLLIVTFPEIFGEGYGHSAGFVGIDLLAQGVGNMLGLIVTVKAHEIIYERQTHPSKHYDPESRLVPAFPGALLIGAGLFLYGFSALKYHFIVPLVGFVIFAAGAMNIFLAIQLYIVDCFSFPASAVASLSFLRFVFAGVFPLFGSRLFQTLGVDWGTGLLAFLSLGLGVPFLPLIYIYGKKLREIGKSNMQKLASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZQ8</accession>
    <name>A0A179TZQ8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_16815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT00953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00953">
        <property type="protein sequence ID" value="OAT00953"/>
        <property type="gene ID" value="BDCG_16815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16815"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="119" mass="13582" checksum="4C043D57465C0F59" modified="2016-09-07" version="1">MLSFPLLVKGVSISYGVFSTSFASLIRLFGPKRALSRQCMIKRGFSADGTRKMVPGATQKPEGNEAEEMCHQKKRGNNDHPLFSRPMHMCAKGRMQSMYRMDRLRNCTAREYEIDEKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZR6</accession>
    <name>A0A179TZR6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SVP1-like protein 2, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_16873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01040">
        <property type="protein sequence ID" value="OAT01040"/>
        <property type="gene ID" value="BDCG_16873"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16873"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="369" mass="39694" checksum="29669F66F347F35B" modified="2016-09-07" version="1">MNTRQVIDTSTGPVSHSAAFNTDSSSFSVGLDTGFCVFNSEPCELKVSRDFNAGIGVVEMLGQSNYLALVGGGRKPKFPQNKLIIWDDAKQRAVITLEFRTSVLRVRLSKSRIIAALHNSVHIFAFSIPPQKLSVFETADNPHGLICLGSKLLAFPGRSPGQVQLVELETGNVSIIPAHSSPLRAIHLSPNGEVLATAGETGTLIRVFATTNCAKMAELRRGVDQAEIFSLAISPSNTLLALTSDKSTLHIFDLPHARKATPPVEGANQKWGILGKLPLLPRVFSDTYSFASAHFEIGDEGPLGSAYLPPLGSSLGRPSKGVIGWTSETTLLVISAGKEGRWERFVIGQGDDGKRYCVREGWKRYLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZS2</accession>
    <name>A0A179TZS2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="7">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_01946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00131">
        <property type="protein sequence ID" value="OAT00131"/>
        <property type="gene ID" value="BDCG_01946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01946"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="8">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Semialdhyde_dhC" evidence="9">
        <location>
            <begin position="105"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT00131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="303" mass="32316" checksum="B2E51B24A91124A6" modified="2016-09-07" version="1">MPASVADLTVRRCAPSEFSDCDIIFSGLDPVAAGDIEMAFLKANFAVFSNAKNYRLDPIVPLVVPLVNAGHIDVIPAQRKHYGLDKGLIVCNSNCAVVGLVIPAKALIQKFGPIESVSMVTMQAVSGAGYPGVSSMDIFDNIVPFIPGEEGKIATESRKILGNLNPDLAGFSDQQPLQVSVACNRVPVLDGHTVCASLRFVNRPAPTASQVRDALREYKSEVQLLGCPSAPRQAIHVLDDVDRPQPRLDRDTEAGYACSVGRIREDDSGVFDIQFVALSHNTVLGASGSSILNAESAILKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZS3</accession>
    <name>A0A179TZS3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01050">
        <property type="protein sequence ID" value="OAT01050"/>
        <property type="gene ID" value="BDCG_04173"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04173"/>
    <dbReference type="OMA" id="TNAREQF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="689" mass="79183" checksum="2B2E75A39EF81295" modified="2016-09-07" version="1">MSYSRHRQPSPVRKPFVDPMRASTGNIVVGSDIDPYNIPRVAYDGYYSSSIAGDRNLDSHYRSYYYPRRSPRLNEDRPIDTHPISSQAYRLTNQPITSRTEYAVRPRSNTSSVADSSRNPLGVTKPPSNLLFAGYDGSRPPRPSSYYAANDAGRYLVPASSLPSRHRRIFSSDDREGRLTLDDNKEATARMENARYLVAGRSPRRAYPVPTPINKPQSIDIGDSYSYTNPAEQFYRDFEATQDYRRDNFERRKARPLSLTGLERYLPHIPIDSRDSGPPPSTRGFDKISRGEIPRSPSQNRVGGAASHSFDIPRRRTKVPVSLHQDRDKISKDHEYDDSRELQSYEGRYDDSPSITEDFHHRNHREDMRYRQVPRIDTEIKGTEDIPGSSGLATVSLTGGYSKDLRKGYDDDLGTRADGRKARDLTCGGRSSHKHDQPTKIQSEDETDTDEQLSDKDQRRRRYAATEHSRKDHSEGPTAARRTYRLNDSEYDNLDPRRLEEPSHRPSERLLSDGFIVSTPVDISDERQRKPYHVELTRPKEPEQLPKGILKPPKDKFPEDRTTVREGVAPLKDATKKGIPKGARWTKVDRKLVTPAALEGERFEERPDYIIVLRVLTLEEIEEFAAKSAEIRARYEAYRNERRRRRDDGEHSDEERKPRLAIESTPDSRRRSPPNSYYSESYKSRAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZT1</accession>
    <name>A0A179TZT1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUE domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00141">
        <property type="protein sequence ID" value="OAT00141"/>
        <property type="gene ID" value="BDCG_01997"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01997"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="432" mass="47387" checksum="7C5197D292BBFBFF" modified="2016-09-07" version="1">MSDGEKTALASQSNHPESPTTARPLDFDDEPQESGVIPMQTPSAPNLSSTGGNEGAPPKPPRPLSPMQQAEINLKEAFPSIDASVIKAVLVASDGNVERSFHALLGMSDPDAQVELPPMMPPRPPRKDSPTQRQLEADEMYARQLAEHYSGTGQRHRGPNSAWDHEPRLPRPHRETGLKPNELYDDREHNFFEDDLPIIKENIRKGFLETQTKVNTWVQSFKKKLEGEDDEDEYGNTPPRPAQGYAQGYGEPQTYRTRRSGEARRSGDRERYDADPQVLGDDFSALELRDTEAQPPRSSRPLANPDLFKSSSPSPDRRKVSFQEGPPDEIHGAYGPRAASDRNRQPPSTGGNNKSSKWQPLSAVEPSPVGDNDPFSLGDSDDERELRSNNKDLKPDEAERVKEATAEAMAGDIGGDSAKAGSNNASKPAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZT4</accession>
    <name>A0A179TZT4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal specific transcription factor domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99641">
        <property type="protein sequence ID" value="OAS99641"/>
        <property type="gene ID" value="BDCG_00942"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00942"/>
    <dbReference type="OMA" id="CTHIWRC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="Transcription_factor_dom_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal_trans" evidence="2">
        <location>
            <begin position="219"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="645" mass="72056" checksum="E2FCBC67BB27A66A" modified="2016-09-07" version="1">MSSIKQVQDLERQLAQAKQQLRQLRSGIPKIDSLMDPDFELHDDTPRIPEVGQRPNRLNFTNINLPPSHVCSKMRTYGQGLINFPPNPSLTHLPLLLTGDVPPLPPASVMDALLGQYFSHIHSVFPIVHWPTLLNDYDQVSRVRSLHGVTRGWAAALFAILACGSLHSLDQDLVSKGKDFLQTSVGLIDVWQDTFSLNQVRTAMLISIFLYETNLKSASWVWLGSAVRIAQDLGLHIESAYSPMETVLRRRVWWALYAWERLVVLETGRPLMIHDEDCDVELLSSVDDRLTDGDSLSRGEKLAPVLAITHVMRAVSQLTKSLKTLVISTDTLEAFERHFRLCLATFPLDYRMEANHYLHPRALSPIMFMQNTRLVLHRHNISPRSSTEVRHVALGRCLAISRDTACLLSRCMLSPNTPKVGPIAQQGGHWRHVMATAATTILCCHIWRCTLILLLQSDYAGALVCVQASAAIGDARLVNAACGRYVAFFLKCMLEKARRHGPENLDRDEEMMAYVSGDLQGRASGSWIWQTNENESASTVTQPQSVTSSKLSPLGEQFVDGAPNGAAVDASEREWEGWGWVEQTVQLLLTEQQQQQNLMVGTKENGTRFSGLPRSSLPYNRPPENISPSRNGSTSHSRMTIANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0I0</accession>
    <name>A0A179U0I0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane bound cation transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_03545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00779">
        <property type="protein sequence ID" value="OAT00779"/>
        <property type="gene ID" value="BDCG_03545"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03545"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="8">
        <location>
            <begin position="402"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT00779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="565" mass="61177" checksum="BC3F02410EE74B94" modified="2016-09-07" version="1">MCFLFGGLRYREQLYNSNITQMSAALLSLSVMSLLLPTAFHASFNNMETADAVVLKVSRGTSVILLLVYVLYLLFQLKSHAYFYESTPQHKIDEESHPGVLADMLNSPSSSESSSSSDSDSDGTSGSYTRTKRIKNALKKRRRHKQSINSKDVRQSFSSASFSRTVSSSSQPMTESAPSQSKRHSEFMSAGMEQAVSVNEVDTDETNTTQDSPRSRPVCKDFACPDSSVNIHGSRHKQTKNRHNHNEGKERVDSVNSPVMDQNGRDDHPTFDSTPPTHAKRQVNFTTDSANSAEPMAAKLPLAARSLSQRQVLPRVFMNKPHLYSAHSTTTAPFGSQCSSGDGECGLRRANSLPGRLQSPFSRPIMPSAQPLPRLMTIAPSQGPDGIATEAIGSCHISRTASIILLVVSTALVAVCAEFLIDSIGYLVENTGVSQAFIGLVILPIVGNAAEHITAVVVAGKNKMDLAIGVALGSSIQIALFVTPVIVLLGWCLKTEMSLYFSLFETISLFASTFIVNYLVLDGRTNYLEGALLISAYVIIALAAFFYPSCENLSMASGPYDAGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0I4</accession>
    <name>A0A179U0I4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00401">
        <property type="protein sequence ID" value="OAT00401"/>
        <property type="gene ID" value="BDCG_02676"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02676"/>
    <dbReference type="eggNOG" id="ENOG502SCEJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="147" mass="16319" checksum="2ADDB74BF5609F8E" modified="2016-09-07" version="1">MSDIEEEWKPTGRPQSTMARSLAAALDNAFMLDSEVDSLTQSVHYKQQMVTIQNRELEALEARIREAEMRLKESSSRSASPEEQASNNNAQNGSDRREGDMAGPFPSGQDAEKRHASSSDANDSTNRGDGPTRDDTKEREKSVDRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0I6</accession>
    <name>A0A179U0I6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99901">
        <property type="protein sequence ID" value="OAS99901"/>
        <property type="gene ID" value="BDCG_01539"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01539"/>
    <dbReference type="eggNOG" id="ENOG502SU10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="258"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="465" mass="51166" checksum="7A2CA27F4A24857C" modified="2016-09-07" version="1">MPISPRQRDGRRNSRSTDEEYVVFLQGIPPQCRWQELKDLVRQTALHIRQAVVYDDSHGHPTGLGQIIVKNEDEAWRTYNRLSTNGWNGNSLTVTLSLASAPTEPIAGPTKSLPVSRIPYAGGGYSSPPRCAPLVSSPTSTMPPENFPAPQPYATSLDYTHFTTPVNLHAQHQHPLVPLVTDPLAYHFPLIYPSDVHFPMQTTILGQQFEHSPATIHRYSTSLCIQPLYELHSANMPRLTNNNNNIRMFRDDSGVHSCSIFIQNLTIDTTCQNLKDHLRTAGIVERCDVREDRKGGGRYPRAYAIATFRTKEEARRAVTLLDNSYFKGSRIRIRFDRDCGGSRSGSGNWVDINGHGAVFTPYRIARNKNLNENGNGNGGSRMETGTAVGNGNGGKAVTAAPISTDLKSPTDSTDLSPRSSQDGSPKRSEPLVVNGSRVGLKAGRASGETVGSEADLSRRIQEIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0J7</accession>
    <name>A0A179U0J7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_05662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01625">
        <property type="protein sequence ID" value="OAT01625"/>
        <property type="gene ID" value="BDCG_05662"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05662"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="PTHR19229"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="462"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1200"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="511"/>
            <end position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="1232"/>
            <end position="1239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT01625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1522" mass="167559" checksum="8F2BBFBBF5E939DC" modified="2016-09-07" version="1">MKDNNILVLYPPFILYYLFQPSPHWLSTPLRALFLPLLFVIFLSYSGNLFFPSSQFGIGEPRPVRTLSNAIDGASGGRNRIVLVNSGFSGGEIDLVIKNVTAPLRDLDIEVKTFQTENELRTECRGSFRGSSRCICAAVFYASPSEGSGGRWNYSIRADGVLGTKINTKAGDNDAQIYTLPLQHSIDFAISRLGALKSSNGGSSSKTIFEYPFTARTHEQQQDDIHSKYMNNVVNILAVAFYISMVGVLYQTTGLIATERETGMAALLDTMMPNQSRWQRQMIRLTSHHLSFVIVYGPGWVGMGTILGAVAFRETSVIIPIVFNTLSGLSLTSFAVFTGVFFRKAQLSGILAVILSLVLAILAQVSGKVTTWVMAVLSFIFPPMNYVYFIITVARWESQTKAAKLLLPAPNSPSTLPAIVFWIFAILQVVIYPLLGAFVEGGFYGRASTSRKTKISNSPVAIHLSRMSKTYRPSFVRRAISFMTREHLTTVHAVADLTLQAYRGEIMVLLGANGSGKSTTLDAIAGIHSISSGRIVIDYPHSQGTLGYCPQKNVLWDDLTVAEHVKIFDSIKSVGPRSSAENLRVLIEDCDLAKKVSTYSKHLSGGQKRKLQMAVMFAGRSTICCVDEVSSGVDPLSRRKLWDILLAERGKRSIILTTHFLDEADLLADRIAILAHGSLKAEGTSVELKQRLGTGYRVHLYNMPGVIKPPVYGDVLHANDEQGTVYYPGTSACTLMFLKRLQGDGVKEYQVNGPTIEDVFLKVADEAKSGHDSFDHGSDTRRLLAKPPAPLVSMERGKSSTRLELLSGRRTSLLKQLTILFSKRFTILQRNLAPSIAALAIPIVAAGCASIFLRNVESVDCNPALGASVSALESSSQSFRLIAGPKSQLSEVAHQRISEAPPGSVNFVETLSQFDYEVRRQFANLTPGGFFLGEKPTFVWRADVPIVPGIIVQNVMNMAVYPAFLSLYPTVERLRAVRSMHYSNGVRALPLWLAYLAFDFLITLTIASITVAILASVTGIWYRMEYLFLIFLLYGVASTLFSYVISLFSPSQLAAFAVTAAIQAGMYLVFLVVFVVTLTYVDASQQNSVLSIAYYSLGVTSPVHSFSRALYLSLNIFGATCRGREIAAYPGAMDVFGGPILYLFIQSFILFGMLQWKDAGPSVQFWSRTKSGTDAEDRDTIELETTAEFARISTSSDDGLQVLRLRKQFKKHLAVNDITFGVPRGECFALIGPNGAGKSTCISMIRGDAQPSSRQSQIFIDGVSALKHRALARSRLGVCPQIDPLDPMTVAEHLRFYAKVRGISNPRHNFKEIIKSVGLEEYADRIATTLSGGNKRKLSLGIALMGNPSVLLLDEPSSGMDAVTKRKMWRTLSSVTPGRSLVLTTHSMEEADVLASRTGIIAGKMLALGTTDALRQRYGNGYSIHMAHSQAPHTRPVDMKRMEMWIQQQFPEAEMEKGMYYGQVRFAIPGRYGQGRSLVEIFEQLEQGKDRLGVPYYSVSRSTLDQVFLSVVGRHFEEEDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1K5</accession>
    <name>A0A179U1K5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAT01189.1"/>
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        <property type="gene ID" value="BDCG_04542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04542"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="207"/>
            <end position="234"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="385"/>
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    </feature>
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            <begin position="356"/>
            <end position="375"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="419" mass="46098" checksum="D6DEE27B3C55B103" modified="2016-09-07" version="1">MYTPSSPHLKPPPPLRNASEFDKTTKPPYFESHRFLENLFADVRVCVLGAKAEDLQVVTPAGNKFVETVQYLHSKLHAATDLERFENFSLNDFLNRVLKFRLNSDKAGNNQDRYEAILRDKPFADEESDNFSERLTFKKEFEQANQFWLSQLAKLHIAALVKVKNWPERKVQAEGTEDFEKEYTTYFLSDDEPKEIFRYALRCIASPGSNDGNTRSDDAAGTPSRESNISRGDAVTMLQRINATGTPTHGSNTLRGGAVTILQRSNTAGTPSRGSNAPRGGTMAILQRSNTAGTPSRGPNTPIVGTVTILQHSNTTRTPSCGPDTLRRSAVAILQGINAAGTPSHSSNTPRHGAVTILQRSSTDRTTSRSSITPRGGATPMPLPSDADVAHLFIEDDFQLHGDDNDDDQRTIRGVNNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
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                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT02016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02015">
        <property type="protein sequence ID" value="OAT02015"/>
        <property type="gene ID" value="BDCG_06554"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02016">
        <property type="protein sequence ID" value="OAT02016"/>
        <property type="gene ID" value="BDCG_06554"/>
    </dbReference>
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    <dbReference type="OMA" id="FLIACHI"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="21"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="308"/>
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            <end position="267"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="281"/>
            <end position="308"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="390" mass="43847" checksum="32F1E8BBF1277E15" modified="2016-09-07" version="1">MFENHGNLLQSEESDVQLIDESSSRNLKPDSFCIHQINGSTNTLITTVEYKPPHKLSVENLQMGLRSMRFWEHIVQSDTIPDKDKDEKLRYHAEQLTGSVLVQKYHVMIQHGLEYSYITTGLAIILLHISYDDPSTLYYYLCELNTDVTSENSEVFQSKTAVVRILCFCLMCFLSDIRNQEWRNAARSQLNTWISSFDSTQSEIPNNELQQTPPELEYPSSEYMLSECLPSSPLQPGRRVSTQSRTTCAPIDTSLQSDHIDSSDSDSGPASHGRKRGFSQVMSCPPSQRSSARSAGPSPRPSSGQHQHTTHYCTQRCLLSLQQRGELDHQCPNISLHQQGQNGDHHPIDARKLVQLPKAQLDCDLDHNCTPFGICGLYGAPIKITCAAYG</sequence>
</entry>
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    <name>A0A179U1L8_AJEDR</name>
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        <submittedName>
            <fullName evidence="3">Pre-mRNA splicing factor, variant</fullName>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="BDCG_06586"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAT"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="Prp24_RRM1"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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            <end position="942"/>
        </location>
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            <begin position="823"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OAT02026.1"/>
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    </evidence>
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        <source>
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    <sequence length="993" mass="112081" checksum="F40EBB2A16F6AA18" modified="2016-09-07" version="1">MDRRMDIISLLSPQDSHSGKSTPAPHPAAAASSSSSGATPTSAPTPSPVSAVSASASPHQNYHKSRQNSGRSGMTSSPLVHQVLNNPQLRDPSPQDLSQGNGTGTPPPSELQPTRQTSTPGIDALADLASMQRPQPHRANPPMRRNTSTEIHESQMSPSTLNPTVNPIPRNHTTPRPHFDVSEGLKEANRRDFSSSSLTPDMQQMASELYAYIQQNHHAYDARVKFIRLLHQGFVEHVYPPSSPGSRGKPQEYDFLQDLRAAREELDGLFAIGEDLWVEWIQDESVLARTVEEQIGVMELCRRSVDEEYGSTKLWIIYGEWMLHLYNSVSQPNDASVSRQWSEEDRMVAREAFTWQSVVEVWMNAAEATNWRINDSHLVWDRYLELVVQDVGKQPSPEKLGHVRDLFVNRLQVPHMTWDNTFQLFSNFISTYYNNYYEETMVDMTNRAARAKALWNAREMREVELRRAAEAGDSTTELSLFVSYLEWELSQNRRKGHFSFELVCALYQRAVLRFPIEVRLWEDYIMFIVEESMDGSPHGHYLPALPSLERATRHCPWSGTLWSQHILSAERVGRSFTQIADIKHKATRTGLLDAGGIKQVIKVHTTWCSYLRRRAFQPDSTDEDLDVAEVGIRSAIESIQELGEKDNTTVPNDPLFRLERIYIRYLSESGSWDSARETFKGLIARHGHSYEFWIMYYTWELLCWSKFTQSDGSASASRRTPNPSLATAVLKQALQRADADWLDKIRLTYIDHCEHYEDADELQIAVIEIRKAMKARTRRQDKEALQAAAQQSAAAAATTTAPQAETPGVSSATRVRPEAENETTPQGSKRKRTVEELDVNGSASKRPRAADLGADAGTPPPKRDRENATVIVENLPSDVTELRVRQFFRDCGKINSLKLLSRQGTQPSATVEFDTREDALAAQTRDQRTFEDQTISVHIGTNTTLFVTNFPPTADEATAKSLISDSRRLNTTRTDAFVTSNSKRPVLLMQRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2A0</accession>
    <name>A0A179U2A0_AJEDR</name>
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        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, variant</fullName>
        </submittedName>
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        <name evidence="11" type="ORF">BDCG_06262</name>
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    <organism evidence="11 12">
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        <lineage>
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        </lineage>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01880">
        <property type="protein sequence ID" value="OAT01880"/>
        <property type="gene ID" value="BDCG_06262"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06262"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="46"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="143"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAT01880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="238" mass="27105" checksum="00A92DC0F9EA4565" modified="2016-09-07" version="1">MGWMVMDSVMLGSLTLYRRLLFEHVFANKQLRRIIPFASKKVPDRLSSFGHGIAGVLAGSTVSFIAAPVEHVKARLQIQYAADKKQRLYRGPIDCTKKILRTHGIQGLYRGFCATLLFRSFFFFWWSTYDIFSRLMKQHTQLSTPAVNFWAGGLSAQVFWLTSYPSDVVKQRIMTDPLGGKLGDGERRFPRWKDAAVAVAKESGWRGYWRGFLPCFLRAFPANAMALVAFEGVMRYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2B0</accession>
    <name>A0A179U2B0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_02911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT00492"/>
        <property type="gene ID" value="BDCG_02911"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02911"/>
    <dbReference type="Proteomes" id="UP000002039">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="265" mass="28987" checksum="CA550EF3EBC6D459" modified="2016-09-07" version="1">MPYFTRKDSKVSPPVLTNALLSYRSPSTHCVTMSVYESFHMVAPSVTYIQCRKNWPVLTLHRHLAIPQTTSTGIASQPRNERLTAAHPFQFPDTTIPTSPGETTNSSSLQTSPGGIPATPITPTRTQIATPSPGDFSEKFPDEKKVEAAKISSIIIGTILFIAIVILGLLLGRSKWNKSVSQTSLRKLHEAEGSTGLVSAPIRRRVPRHGSQRSHTSRDGFIAFDDLSPSERYSPAQELPTVVEERYHQVSTASSPISPCVSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2M2</accession>
    <name>A0A179U2M2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
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                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00632">
        <property type="protein sequence ID" value="OAT00632"/>
        <property type="gene ID" value="BDCG_03232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03232"/>
    <dbReference type="OMA" id="QNDDSTN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="54"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="409" mass="46506" checksum="F99E290E637D58FC" modified="2016-09-07" version="1">MYCYLLIHAKVAGLMSTCPTVVTTVRRLFILQKTAILFITCIGENETIPINYAALGDSYATGIDAGKQLRSSCWRFKDSYPMQLIRTGLLGQNHSFQFLACSGAVLGIPGTSFSKQKSISRQIKALKPTDLATLSIGGNDVGFFNILNACVYRFYGIRSGNCNEQLTKSKRLISSDKFADAYTKTLTNILAKGTGPHFRLLALGYSPFFDEALSEDCTKRSFGYWRMWRPKLTVKLRRQLNEIPLYLNNRIVQLIKVMGDERIVWVDWAPKFKDHLFCQPGKKRPSDGDNTWFFDIDSRSKNLSVDDVDVDACAQHSLDSGDWGHRAACGIVMVREQYWKYPQILRRGSDNEEDEHKDEEDDNFSVDYFPNKRGLARVFHPKPQGYMAIAEVIQSHWPGRAKCSRTTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2M4</accession>
    <name>A0A179U2M4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01558">
        <property type="protein sequence ID" value="OAT01558"/>
        <property type="gene ID" value="BDCG_05514"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05514"/>
    <dbReference type="OMA" id="GKDWNTG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="875"/>
        </location>
    </feature>
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        <location>
            <begin position="968"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1320"/>
        </location>
    </feature>
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        <location>
            <begin position="1346"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1726"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1851"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1907"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2113"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2148"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2169"/>
            <end position="2184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="2184" mass="235370" checksum="0631AD9E9A0ABCDA" modified="2016-09-07" version="1">MLYATAAEPPHNNNNNNNNNNVRSMLIAPANPPPPAKPELPRKRAWCSGDIMTKSPDGYHARNGGGRGREAVSERRSTELKTGLRRAAGFLTMDCCESKSTTLLDSAHAASLKASALVAEMLLSLDSTPLPYGAPPPPYDNVITDMPPEYMSRDEFAHRRVETPASAPTSAVWTETAKGNGLLLGEAVTPPAIDFNDASKFRSHAKKKGKATKKANQDKWNEPEKGGDKGNAAGGDGDGGGNADGGAGNGDGGGDGAGGAGGGDDGAGGGGGGGDDDDGWDLGGSKKKNKKKNKKKEEEEEKKRKEEEERKAKEEEERKAKEEEEEEEEAAAASAAADDNAGNSLSWAGDVSEANADDAWGGFTTTTKKKKGKKNKASTAADPPTAKEPASNSFQDINLGDEPPQLDFSLESGGDTGKTGFNFGAWGNSWNTGNIDLNLGDTQATDEKKDDGTDTLDPWAPAGKKGKKKNATTNTFEFGDSGDGNTEEKKEAEDDAWPSFAVVGKNDKKKKKKVSADIAEEPVPDPEPAPEPAPVDEWNSWSTPSTKKSKKKKGTNSFGAIEETPPEPEPEPEPEPEPEPEPEPEPEPEPAPEPAAEDDAWGAVGKRNKKSKAKTADEPPKEPNPPPEPVVENTWASIPTKKEKKKKNRGITEEPSKEEVPEPEAEPKAEPENDWGWAAPAGNKKKGKKGAVTAVTEEDKPVEEPPAAQPEPEPQPDPVDDWSTFATTTSGKKKKVKKGAVVAAVEEEKLVEEPPPPPPEPEPQPDPVEDWGGFTTTTKKKKGKKRAVGEEPVPDPAPEPAPEPEPEAKPEADPLEEDWGFTATTTKKSKKGKKGAVVEEAPPKVEEPAPVAEADIWDTGTSKKNKKKSKTTKTEEGPAPEPTPAGDDLDWLNDDLGDGGKVTKVDSKNSKASGGSGADGDGWGLGGWSFGSKKNKKNKAAVVEESNIVPEAPAVTGTTSIDAVDDWFGTKGSKKDKKGRQDPIPEKSPIEPEPEKATAVANDEFLGWAGTTSTSKKNKKKGTKAAEEPLPPPPVSEAPEPPADDGWGIWGTSKSTKDKKGKKNKLVEPEPEPEPEPEPEQEPVPEPEQEPPKVDPEPLVEAEAVDPWAGLTAKERRKKEREAKKQAAAAAESNENNAANAVSTDLVRSPALDDNSWGMWGAAADKKKGKKGKDTNEPPPPAPTPPAQDLEPEPAVVDIEGIDTWGAFTGSGAKTPKTKKTSLSRTTTTTSKSPKVEDGKSTRSKSRGFEVVDVTDEFKGKEEPMVEVSAARAAKSFWGGTFGTATTTPITKSKTSKSKEDANKQSVEATKDKLAAEETKKGSNADNLLADTGELEAASATGADKATAPSAPTTKTTTTSTGSIKVTSKTSVAERIKLLEESKKREKEALKEKEKLKAKEKAAAQTAVPQQPASPLDVKPTVDPVANDPPPSKKASVSSKTKSSTVPSNSTSKKNSATAAATATLLDGSSTPRDSVPGSFPGAYEDELVEIVDLAPPPEPTPVQSQPVKASKKSKKASPVKAVIVDEMATPPPPPPGPVPPDENKDAEAPPDRATAKPAKKERPRVERTAGASSWGFWGAAPKKPVKKETKAKDDAGPSSPSTKKPKEKSPPALSRSKSMSSKKGKPADAEKDVEKSSGSDEKRNSTAVRPRHSRGMSFSNFMMGGAPPVRTKSMKQNGASASKHSSRRPSIDIDDSGILSPNGGHAEMSGKAAKFMGVNGTKTPRRDPNGKKRASRAPDPYAIDDDDDLVMVNGGDVPEASSPKDSPVDSKPRRRKSKREQKPRSADDDIVMVEPGPSSRPEVVSGPEDLAFVIDPPKERANLKRSNTTATPKKSEGLLGLFGSFRKHAAPPPEHSRSRSYREEDLRKSAEIDKEYARRARREKRRSTRVETDGEGFTTDAAPATEAEDAEARRAERRARRLSKYAEQEAREAEEREAEERRAKRREAERVRIREARERRAREDEEREQRHREEKRARRAARLLEEQQREEEIRQLEARRRAREADEFGEDGRRVRSERHRSYTDKARDKYSHDEYATDHRRHRSHRSGDEAAKSRRRKSAVLPGEEYYTSPPPIVPTVIDVPAPPGDPHVHSLSSEEEARRSARRKARRHSKYNGVDDAEATERRARRHELRHSVRGPLKSSEGSGEGDRYGDRYASDYHRHSSYANGAPKRSSWFKKITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2M5</accession>
    <name>A0A179U2M5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02314">
        <property type="protein sequence ID" value="OAT02314"/>
        <property type="gene ID" value="BDCG_07207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07207"/>
    <dbReference type="OMA" id="CAQGAIM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="403" mass="45131" checksum="6B12FAC1C6E1FF79" modified="2016-09-07" version="1">MSSHGEKNSDPNIEKPVDEEAIHEQSRAVSGKPWMYKRPKIGSFKFPYYASPTSQLLLVSFVCFLCPGMFNALNGLGGGGQQDPHAVNIGNTALYSTFAVIGFTAGSIANRVGLRWTLLFGGFGYFLYVGSMLSYNHNRNLGFLTFAGALLGACAGCLWCAQGAVMMSYPDEKSKGKFISWFWIIFNLGGVIGGLVPLAQTMNAPEGRAVGDGTYIAFMILMFIGFVLCFFLVESKYVRREDGSQVIVMKNPSWWSEIKGLGEVLVSDWYIVALFPMFIASNWFYAYHFNNVNGAKFNIRTRALNSCLYYLAQMFGAFAFGYMLDTPSLRRTTRARLGLVVLFIFTMAVWGGGYAWQREYTRADTGLEDFRIIDFKDSDYVGGMFMYILYGVYDAAYQTCVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2M7</accession>
    <name>A0A179U2M7_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01181">
        <property type="protein sequence ID" value="OAT01181"/>
        <property type="gene ID" value="BDCG_04508"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04508"/>
    <dbReference type="OMA" id="CSHEYNE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="PTHR10257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="701" mass="78756" checksum="4061674B59924455" modified="2016-09-07" version="1">MKGFRQRVLSRAKDSNKSSKKKDSSGTSSPSQNTTSSSTGPSPSPANSNHGTPTTSTTSLNDMKGKAGLQGGNGGGPPAGAIHNNAQSQLSAPQSAQLFMPPGQNMGGHSGQMPGNGPGTPIRQPQPLAPSVIISPSAPHIPPPGAAETMPGDLQPPKAGQKSNLFDRLQTTPKDVPEGIRTPKRQHSSRFDISDQRQRELEKLPGFHEVPPNRRQDLFMQKIDQCNIIFDFNDPTGDMKSKEIKRLALHELLDYVANNRSVITDPMYPRVVDMFAKNLFRPIPPPVNPQGDAFDPEEDEPVLEVAWPHIQVVYEFFLRFIESQDFNTNIAKAYIDHQFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLNLRSYIRRSINNVFFQFMYETERFNGVAELLEILGSIINGFALPLKEEHKLFLTRVLIPLHKVKSLSMYHPQLAYCIVQFLEKDSALTEEVVLGLLRYWPKVNSTKEVMFLNEVEDIFEVMDPTEFAKVQEPLFNQLAKSVASPHFQVAERALYFWNNEYFCNLVTDNVETILPIMFAPLYENSKGHWNRTIHSMVYNAMKLFMEINPQLFDDCSHDYTELQSTAEAREKNRQGKWDRLQLLAQSRKSITGTGTGPSPLLANTTTNAGATTSSSTPSSDGPQISSRHTDDMDTVTHDSQQRLNALKLQDESSKERRLRERDGQDLNSVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2N5</accession>
    <name>A0A179U2N5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01973">
        <property type="protein sequence ID" value="OAT01973"/>
        <property type="gene ID" value="BDCG_06444"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06444"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="1">
        <location>
            <begin position="77"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="280" mass="30791" checksum="B0C082B6602318C2" modified="2016-09-07" version="1">MSTRIRMWQQLTESLRKLQRMIMPTFIIFKNGAVAHSIRGANPQLLTSKIQEFVSSVGSNGADDAAGEASSSGSQWLGGAVPKGYSELSSEIEIKGIDLLNCDNQVGSGNSLFAAEKPSGFSAVESSGKASSTSDWVESDTDEQLMLYMPFQSSIKLHSLQITSLASPGGDADDDEVPMRPKTLKLYTNRTHIIGFEDADEETPTQEIELTPRDWDENTKTATVELRFVKFQRINSLVVYFVDGDGDGERIRVDRVRLFGEAGEKREMGKLEKIGDEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3A0</accession>
    <name>A0A179U3A0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02203">
        <property type="protein sequence ID" value="OAT02203"/>
        <property type="gene ID" value="BDCG_07029"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07029"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="405" mass="44533" checksum="02AFC3EDFAACEEBC" modified="2016-09-07" version="1">MLGGYFRPADGLKAALAALWVGGPGVPYETFLNAVNADTCVADTRAAESLKRDGSLGDAVEKGFAVAAYLKLVKGTPPFDASCMSNQLKVLGAILDQRWDAPGQCPDKKAPELVKYRSVLFSAGIEVLNTDPVPGSRPAEVVYWPKFKGYPEFCWNEARAQRSNDDLRPRCEPRRLNVFNVTYEDCPDQDPWVICHCSDAQQSLDDVIRRVGQLPPGLRSHMIHLIAFEHSSVGGAAVLPWNMVMIFGEAQDSVYMHEASHCIDRGFYASETFRTAKAKDSCWPTHYSKSADIELFAEIGVLYLYDKSGKTLIQRGHDPACLANGLKAIDAYVGLDYQRGGSKCFKRKPNSKVVYPPGFQIQSPEPYISNAVIENFSNPGDVSSLSSLSSPASPWGDYPREIHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3A1</accession>
    <name>A0A179U3A1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ chaperone, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_03798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00892">
        <property type="protein sequence ID" value="OAT00892"/>
        <property type="gene ID" value="BDCG_03798"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03798"/>
    <dbReference type="OMA" id="GFPWSSF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="210" mass="22924" checksum="96737741AB0A5017" modified="2016-09-07" version="1">MGDTGVDYYKILEIDPSATEHQIRFAYKRAALKSHPDRVPTTSPERPAREETFKKVNEAYYVLSDPTRRRQYDNGRSRQQQQRKPRTPSPPAFSSGPETGSDSFASDQFGSIFEEMLREEGLSEDDAVHGGTRPTGRFWAIVGGLSGAALGFIVANFTGAVAGAVAGNRLGAVRDARGKSVYEVFQALPGEDKARLLSELAARVLRSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3A3</accession>
    <name>A0A179U3A3_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="6">HMP-P synthase</shortName>
            <shortName evidence="6">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_07720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02546">
        <property type="protein sequence ID" value="OAT02546"/>
        <property type="gene ID" value="BDCG_07720"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07720"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="NMT1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT02546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="285" mass="32173" checksum="E64728A69E7D6038" modified="2016-09-07" version="1">MGFKAMIHTLAAKARNFPVVSVGSLLDEPFTGIVYLKDSGITTDFRTLKGKRIGYVGEFGKIQIDELTKYYNMSASDYTAVRCGMNISKAIKRGEIDAGIGLENVQMVELEEWLAEQNRPRSDVQMLRIDQLAELGCCCFCSILYIGNETFISQNPEKVSKFLKAVKKATDYVLANPKEAYEEYVDVKPIMGTPVNRKIFERSFAYFSKDLKNVQRDWVKVTNYGKRLDILDASFEPNYTNKFLSWELEPESGDPTGDQCRMADLQRKVAAEGGFRRLEAAAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3A7</accession>
    <name>A0A179U3A7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Salicylate hydroxylase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_07756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02554">
        <property type="protein sequence ID" value="OAT02554"/>
        <property type="gene ID" value="BDCG_07756"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07756"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPQATRW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="4">
        <location>
            <begin position="4"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="370" mass="41170" checksum="BDA007595958E592" modified="2016-09-07" version="1">MRSVLRRLGVEPAIKKTSVVLERIQVVRWQDGRVLNETAVNHQYGEAAAIHRGDLQKALLDRILELDNIQIRAGATVTDIDFDLTAVHLQCGKAVYGDVVIAADGIKSTVRRKMFPGIGHRVQPSGDVAFRILIPREKMLEDEETAKLINKPQAVRWVGPHRHVIGYPIRNHQLYNSVFVHPDNGPTGESWTIPGTREEIMEAFGGWDPRLSKLVASSTSVLKSRLCLHPRLQTWVKGSCALVGDACHPMLPYIAQGAAQALEDAAALGVVLSQIETAKDVPFALYVYEKCRKARAERIQQSGTDIRIELHLPDGPEQVKRDERFAAAMKGAKNPDTWNDRETQRAIWGYDAEEAARKCWSSSRGIKGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3A8</accession>
    <name>A0A179U3A8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ulp1 protease, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02213">
        <property type="protein sequence ID" value="OAT02213"/>
        <property type="gene ID" value="BDCG_07038"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07038"/>
    <dbReference type="OMA" id="LLDPPNW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="PTHR46468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ULP_PROTEASE" evidence="2">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="251" mass="28860" checksum="A41BC6353F685861" modified="2016-09-07" version="1">MGEGGFNRFKDRMRGRFGDSSSPDDAYLSYHDVRLTNEDIYTLKTDWLTDNVIAFWEEYLEREFLVNYQSANIVLLRPSMSFMLLQTPDPRTLRDVLPDFTKTSHIFLPINDCRNVNEAEGGTHWSLLLVSVVDGVAFHYDSLPPGNCDEALQATQKLSHLLNKQLRFINLDDSPVQENSSDCGVFVCLHMRHLLLKRLLMANSSEKISMSLRGMRVNANNGRKEIVRIIERFRKKGQRRRSHSIVLTGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3B0</accession>
    <name>A0A179U3B0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING finger domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_07149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622448.1"/>
    <dbReference type="EnsemblFungi" id="OAT02280">
        <property type="protein sequence ID" value="OAT02280"/>
        <property type="gene ID" value="BDCG_07149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07149"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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            <begin position="54"/>
            <end position="74"/>
        </location>
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            <end position="234"/>
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        </source>
    </evidence>
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    </evidence>
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    <sequence length="679" mass="72065" checksum="8A44E64E3D577BC7" modified="2016-09-07" version="1">MHILPSSLAEVVMPLLWICAFTLLSMPAQAQVSRPTNDSVDTFLPITKYELLTMQLTLGPIGLLPLSTALRRLFRSLIESRFNITGTLVIIDANNATRLNGSDIALVSCDASVSSGESDVDDALRLAITGAFTPNAIILYSTESSHCSYSPGALNWPPFMNIFTITSSLAASELTTALLSGGRAFGESIIIPSMDMGSSRPGSGGQRNNAMIILYSITGIITALFLTVIITGAVRAHLNPDRYGPRNTAGRPRQSRAKGIARAMLETLPIVKFGDPEDERAPTAKQDLELASNYPDGEHDHRRSDARTDGVTTPKTRQVDQHQQQLQPVAPQQERTATSATVASTSHVVANTVKEQDEGVIGPASPELNPVNQDQLADSGTLGCPICTDDFVKGQDVRLLPCQHKFHPECVDPWLINVSGTCPLCRINLNPEEAEPEPDVAATPTSTPSRATTPTPPSTLARHSGHSHHHSRTPYARRYRRVSTYFVPASTRGMILDTGTENDSAEQEHQRQRRLYTLRHMRGSSEQHRTNDGNNNVTATGAITEASSSPAVAEGSGQGQMDEASRRNRLSTWLRERFRVRTRRHGESDGDDDGGGGAGGAGAGAGAGAGGIAKPGTSTQTDTDATATASASASASASASRSPAANPSGDTDTAADISIPTTSTPTTPIQQPTTSAAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3B1</accession>
    <name>A0A179U3B1_AJEDR</name>
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        <submittedName>
            <fullName evidence="3">Murein transglycosylase, variant</fullName>
        </submittedName>
    </protein>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
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                <person name="Priest M."/>
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                <person name="Whiston E.A."/>
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                <person name="Zeng Q."/>
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                <person name="Mardis E.R."/>
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                <person name="McEwen J.G."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
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    </evidence>
    <sequence length="238" mass="26246" checksum="CCC2A17EAC5D4E76" modified="2016-09-07" version="1">MQAPDVYKVHDEYHVYYSVSTLGSRNSAIGLATSRTMEPGSWTDHGSVGVQTSERDNYNAIDGNLFEDADGSLRFNFGSYWGGLFQVGMNNDGTRTAPLSSAVNLAYEPGWNHHIEAAFLYRHHNDYYLFFSWGKAGDYDISPPAPGEEYRIKVCRSPMPSGPFVGSDGRPCTEGGGMTVLASHDNIFGPGGQGIMTTPEYGPVLYYHYTNTDIGWSNAEQLIGWNRLDFSSGWPVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
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    <name>A0A179U3B4_AJEDR</name>
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        <name type="synonym">Blastomyces dermatitidis</name>
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        <lineage>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
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                <person name="Zeng Q."/>
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                <person name="McEwen J.G."/>
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        </source>
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    </dbReference>
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            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107170" evidence="1">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="111" mass="12255" checksum="B35D8647C43F8A55" modified="2016-09-07" version="1">MIPSLLSLTALTAPLLHLLLLLHLLLAHLSTATLLLHPIPQPSKPQCSQYYEPLCCRNSFPQMYPKNAVWAYMCRDPEGGGSCLPTIEEPLCCPPGRLDYCIKFGSPALHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3B9</accession>
    <name>A0A179U3B9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT02290"/>
        <property type="gene ID" value="BDCG_07163"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07163"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="710" mass="77421" checksum="F27C0E6B0B477AC2" modified="2016-09-07" version="1">MASIWRRMTSSPDCRLDEDASKTQSSLRSRRVKKDLHRRRSLAGLFTTSPPSKEPDQNITTITCEERIHYPLYNPRDPRHNIDTLACDSKDKGFWTTYGRSIRSRFQGSAKSGTVSPSIQQRNSRRSIRSSFVSFTSSSRLMKRFSRSETPSKPPLSSIWEPQSASQEVACKLLPDKIDDSQLSGFHEALGAPRQYLLPSLPSMSSGLMSPLELEACTAGAHTEQETSYPQNYGSGPQTFSRPLQPFHILRNAVSSMSSGQSAVQAHPKYANISNNRSEMASSPIPITSKRPPLNHQQARMVKARDGANMSTLLSKQMHSHSSTLDDKKNNESQISKILSNGAKPESLLNLGEQWLETRMQPLREVSPGISQPSTATDSEFGVEMHRTSGPHYYASTTESDAVLSSWLSSLSSISHPRDNTDISGSTLCRSPPSSTRHPSRAGQAGLVQGLSGSKTRHCSEPLIRDKAATNKREETPSKSNSLRPEVSTESMGQENPDNPNSSEENSNPVSNSFRDNGDLKTAFTKGDFWSGSIDSRIRNGDLKQLPNENRPDSPVLDGHDTDGHGEVQFATECPIMPVTHPKETRAPSYSGNTRPPQSVSQDAPNRKIISTCKTSCIPCAKTPTDCGTTPMERRESQVADDRGSKSSCTRKNGSSSGSGSGSGDSGQSDPLTNSTAGTSVVDFTSDQNLTAKRNEDQRTASPMGIKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3D0</accession>
    <name>A0A179U3D0_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_03874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00922">
        <property type="protein sequence ID" value="OAT00922"/>
        <property type="gene ID" value="BDCG_03874"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03874"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="PTHR24056:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="298" mass="33732" checksum="5E523C73EAEEA80D" modified="2016-09-07" version="1">MDAIREVKYLQELSHPNIIALHDVFSSKDQNLNLVLEFLPLGDLEMLIKDRNIQYGAADVKAWMGMLARGVWFCHESFVLHRDIKPNNLLIASDGEVKLADFGLARSFADPYLNMTHQVITRWYRPLELLYGARQYSGAVDIWSMGMVFAELLLRVPFAAGNTDMDQISKIIGAFGTPTEENWPGVTKLPNFVPIEETQITPLQGRDFFIRQFPTAGPLGADLLASMLKLDPRKRSTARQVLQHPWWVAEPRPTRNEDLPRKAGGAKKMGDDLVRRGGEVDDTRFKNAARQLDFSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3D9</accession>
    <name>A0A179U3D9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Telomere silencing protein Zds1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02584">
        <property type="protein sequence ID" value="OAT02584"/>
        <property type="gene ID" value="BDCG_07812"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07812"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PTHR28089"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zds_C" evidence="2">
        <location>
            <begin position="691"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="851" mass="93911" checksum="4AA459A8D3521727" modified="2016-09-07" version="1">MMQTSTSPPYDHSGGYSARRGRASQLSISDDSQHVTETIGYMYGDDYDKRDSKRLSFTPSSMNESLSVTSPRRQNLPQPSDSNNYQRPLPLRTSSIDRSASNDSDRQSAAEPGSSDRDGTGPCSQVLTRSPSTTTSISIPLNDIDYESNPAAAVAQELSNLAALRRMSMDVGAADPDLPLFGSNFGIPPIPPSGESDDDASQLFWVPARLHPGLAPKEFKSFLDGKAEQIKRRSGELTMTDSELQVQGLTGGLRRKKSMLSRQIDTSGSGGQNEGNQLDSVSEEVSVGQRRAKDSMVDDRPILPPAPPGHSLRRSTRTTYRRGSLKTGDRIPYSRRAPRQSDPDAEAVARRSPPLGEEEPPILGLTRVATDPTHGGTSGFSRPTNWSPASSATNNLSISSGESNSDPLTSGNRTASTPPSQTRSSWDLNDRSNLEPSAATQNVHQIIQTPPADVKESPATATASTPNHIPVRKSSHDPPPSQPPQAPLPPEPIGKRSSKRAGIIRPAKESSQTINDIASRPAALPGNSTRTDTLSFIPTLTDSSNKKSDSKKSKDKKDGEGGRKSSWTWRRGSEEKDKDKKKEDESKRSKGRMPKIAEKVHDNTRLDLLQASIDGAQTGRESVVIDRAEVRLEEERRKDTAKRGAGNESKKEKEPSLFSSIFGGKKKGNLDYSQKKHSSRTLSPEPQPRELKPDIDYNWTRFPISKEREIYRYAHWKLAEPKRALHSQVLLSNFMYSYLAKVQQMHPTLSISSAPQAQHRKREHSQSEDHSQHQRHQSREHDNYNNGSYYNESHYDYDSDDRDDHHWSQSGGRGTSSQNGSAHGSNQRQQYGASRSSFGDEAQLDDDDDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U403</accession>
    <name>A0A179U403_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">N-acetyltransferase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_05868</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002623312.1"/>
    <dbReference type="EnsemblFungi" id="OAT01711">
        <property type="protein sequence ID" value="OAT01711"/>
        <property type="gene ID" value="BDCG_05868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05868"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033257">
        <property type="entry name" value="Eco1/CTF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="PTHR45884:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="zf-C2H2_3" evidence="11">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyltransf_13" evidence="12">
        <location>
            <begin position="428"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAT01711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="500" mass="54885" checksum="9F7D38FFF0A49557" modified="2016-09-07" version="1">MADTYISPNFSNLNSTSNNNNTATTLKNRCNTHVQTSTAGLPMNPLFMITARDMPYTVTNSFKRGVMMHTYGRPIRRVCYDDSRPAAKKRRVQADTAPKDSAEDENNLECAIRESSAAILSSPSRRNSTAAFSEDLDDDLSTPPSSPPLQLTPPPVNTRKPTFAFLRRKRAAATNTPTNGTPLTEVNFNSVRASMDPPKKKPKQQQQHRQQTQSQQPTLKQMQLDLGGEVRKTCATCGMEYIPSNAEDVALHKKFHDMNSSGVDLGKAFVRANACRWVYEAARFDEGYVVIVDRKSSPSARGQAMRVLEVVNKELSAPDIEEAVLWSQTEPPKRLRKNGAKEEVDRFKVFLHMKDSRCVGLCLTERIWESHLVKRPGRGGRTGTGTGTGTGTGTGTGTGTGTGTGTGTGMNGERPNGSSSITASEEVHHAVVGISRVWTSASSRRKGIAMDLLDCVVSNYIYGMEIPKSKIAFSQPTESGCRLLEAFFGPDEPWHVYKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U407</accession>
    <name>A0A179U407_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_05897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01721">
        <property type="protein sequence ID" value="OAT01721"/>
        <property type="gene ID" value="BDCG_05897"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05897"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="618" mass="70008" checksum="1610A210A75E3117" modified="2016-09-07" version="1">MGMRSKVIFASLLLEFDRLIPPKTVFHFFEFACRGTLPNGKKTELPVISSEEIPLVASPYSEWALPPHNKITLPVSHMLMSRVGSDEDPGRLALVEKPVHAMKARLWEGIPPISEHQWRQKGLDKAENFNYACQYIEAVISAFDYLNVPLHISHMRETFNYMSDHLSEFDEALNNIRRRDGKEPNINTAGLWADFILAKYEVMTDRAHSWVISHVDALREPLLNEIKAQGPSSDDTISPEQLDLVHKLRKLAGLAAEADYTIYMSTYGYKNSSGPSPGRMGDWRNTVLEKRRQTYVNSYAYFQKINSLTNEMLANLAGYYPTESPDASPKKENDLLKAIEGQLRIQDQQRLRARSDPNPGPRAPPVWISDVTSRIRDIKNLGKPPMTEVGFAIYRLSYGQNDDGVEWAALKEAIEKDLASWGDGIDGVEDIKPFLKLKWFDGRELGLAKDDIDGAKRHFITFLNTLTPSDGIDQSTILIIDSASLASYAKPTTDDTDDTEDHFLLAVDAHYDPAEGIERPEESPGYVGSMRILTRLVWSELFALTYNQVMWLDELWPLAMGHPEQVYVGTTVGDLRSRWAAAKVAGDSELKARFEAECKRREEEEVKAWSKKSREKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4D2</accession>
    <name>A0A179U4D2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RING finger protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_06168</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01841">
        <property type="protein sequence ID" value="OAT01841"/>
        <property type="gene ID" value="BDCG_06168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06168"/>
    <dbReference type="OMA" id="IMDLGPY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="71"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT01841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="691" mass="78384" checksum="D576E87F1AED859E" modified="2016-09-07" version="1">MTNPLPLHRQRSNQGPVELVRQPDIPMNSDILRELQDALEERRKREESRQREKELAKLDAEKEATCIAQGNVMECKCCYTDVPIIHMIPCAGENIHFFCKECVRSTAKSQIGVMKYEVNCMDISGCGAGFDKQILAKVLGDPLMKKLEQLQQRDEIARAELEGLHDCPFCDFKAICPPIEMGDCQFYCQNPACRKVSCRRCGLAAHSPQTCEQANDKKTPARQKIEEAMSEALIRTCPNPKCKVKIIKEDGCNKMTCVKCRSVMCYVCKKAITTEGYRHFNKRPNSCPLHDGRSNSRHFEEVSSAHKKAIDEVMKANPQLNIEELAVEAPKNEHHKSVDHRRYLQHLRNQQQHYNDLLRRRQNPGAPANPAQPGAAGPAHVPMYAAVNHNHPLAVAYPQAIPVPNGANQFLHFRGDMEQMNTVEQPPHPTHQPIVRQDPQQPHIWNHGWDFHFIPPAAAPVPVPFPHVPSVHPQQYNHGHHQHYHYQYDHLGYPVQGTPMPQQRVSAARKDQNQNQNQNGNQNQNLRLNQPRDINQAQQHSPPQPQLKNPQGPPKFRIHSNLRFPLSAPPPAPQPVMSTLPNSFGPIPSLNPHPQWNQQLNKPLVMRGVPDKTQSHNQTVLTQPSPLPTQPTHMQARPAVPGQRIASNNNININHTNNNNNNNNDPHHINRPIFRYPVDVPDRGLGEFPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4D9</accession>
    <name>A0A179U4D9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02864">
        <property type="protein sequence ID" value="OAT02864"/>
        <property type="gene ID" value="BDCG_08532"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08532"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="476" mass="54662" checksum="8ABE5C4A5B722B16" modified="2016-09-07" version="1">MEPGALYVQMQPSGKPAFVRRSRRYKTPGSLLADALFNPRPIVQKHSQYQAPDTNRFEPASPPEPQQIPVPSYEQFLQYPPPQQHPIPNPLASFPNDMAQNLVQITDPCEASFPKWEPKIGKPALLVIAEGFCGHCSTRFPHMCCHSCDCRRRRRNRDYNGSKRGCDRIARRNDCGCTREDSCMDSSSESDVPVKKHSHKHKRKGKGRNKSFLKKSANDVSDSSDEEGQSGRVRFREPVRPDRHGANRVGSGIYDPRTGTVHHANRTDGTGHRPVPTVDASMYANQPTVPTQQNLAYAPGYYPPHLPPHPHPDSNAAIPTYQPSHRPAPEWAARTYYDDDRRNYESNTDGEVADSRSHRRRRRGRSPTPTPIATHDLRYPKEERMRSPGRVNVPDTYYDPPDTPYHSDYHYVRPRSPDRYERYPRDPPRERSYSRRRPVPGSRTPGPHSERPRVVEMRRDRRPDELDPPTRPRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4F1</accession>
    <name>A0A179U4F1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01861">
        <property type="protein sequence ID" value="OAT01861"/>
        <property type="gene ID" value="BDCG_06216"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06216"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="310" mass="33878" checksum="F8F46C8962D2E009" modified="2016-09-07" version="1">MGVSRKGTTSLTGNGLRHRKLVNYCAIYTAGSFVGSELALFLICRPITDHWAVPTPNYQCSSYQYYEIVNGCIGITGDIFMLLVGIPLLMSVRLPLKQKAILLLIFGLGIFVIIAALLTKIYCLVPSLISYVYLNWYFREATVAVLVTNLPLTWSLLRDIFPALKNWSSGGSGPTGRLGASLSAPGRSSRGALQSMDYNLQSFTRLTSTVDTGKSAMNGKGHHSPTAISSDDDNSVRSLHIRQDVTITVQSEDARDGSDIGGEHHQNLNDSPPFQPITRPTRPAQAFPYGQWDTSHKISSDEVGHPNMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4F6</accession>
    <name>A0A179U4F6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stromal membrane-associated protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02583">
        <property type="protein sequence ID" value="OAT02583"/>
        <property type="gene ID" value="BDCG_07810"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07810"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="559" mass="59132" checksum="05A637DF68740642" modified="2016-09-07" version="1">MASRRTTNPAAERAAKNQLVIKNLLKLECNKICADCKRNKHPRWASWNIGIFVCIRCSGIHRGMGTHISRVKSVDLDTWTDEQLQSVLKWGNARANKYWEAKLAPGHIPSEAKMENFIRTKYESKRWVMDGPMPDPSTLDVDEGDDNMEKAKLERSASHRAASTVSQPTPRRPGQSVNLFDDDSPAPPERPNTTDLPGIRPPTNHTRPFAAPAPKPNKPADSLLGLDFFGSAQPAANRSSSTPSSNIGSTGPSRPDLKQSILSLYASVPKPQAPPQHERNTSFGSFSPQPQQLAQSQSDAFGGLANAFSGLSFPSTTPASPPPQEQDAFSNLGSSSAPKSPPTAPNISSPPLSGGGFFDSGPKPQRSNNPSISSGRDFNPVGATMGSTKATAAPPATSTSSFDLFSSMSITTPASPPAGPPKTENSNSIFNLSAPERQSAPVSPPTTTANVSSMLSSSAIDPWGGNAWNTTEATSPTNKQTISSMMKVPDKITASDIGSGWGSQSPTSTTKSAPTVAVDEDFGGWTSAPPPIPNSNATSKPRPAGGFSGSDDLFSNVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4F9</accession>
    <name>A0A179U4F9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_06232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01871">
        <property type="protein sequence ID" value="OAT01871"/>
        <property type="gene ID" value="BDCG_06232"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06232"/>
    <dbReference type="OMA" id="MGYGPWG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="291" mass="32284" checksum="0C3C57AD42599072" modified="2016-09-07" version="1">MPSAFATLLENSIPTINYTPVADVPSPLTLGNLDSLNILGGEDIFLTSKEGIRALPEWFRGTRPDRTGKTVDAVSSVIVVRDHGDGKTVDVFYFYYFAYNQGNTVIGIQFGNHVGDWEHNMIRFENGAPQAIWYSQHSAGQAFTYEATEKQGLRPVGYSSNGSHAVYSTPGTHDHTIPGFNLPGGLLEDETDRGVLWDPLLSAYAYSYDNATEIFTPYDASTPTSYLYFDGRWGDQQLPDDAEGQIVLFGQRKYVSAPNGVKFKRLVREEVCPGDGECVIYDEVRVKRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4R1</accession>
    <name>A0A179U4R1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_07009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02197">
        <property type="protein sequence ID" value="OAT02197"/>
        <property type="gene ID" value="BDCG_07009"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07009"/>
    <dbReference type="eggNOG" id="ENOG502RNZJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="394" mass="44254" checksum="B943E74E8A7A218E" modified="2016-09-07" version="1">MTAINISIQLDSSRNLHGPLLFLNDNGVAGKVVVYSCDSAQFDSVRIILEGTIRSSLISAAIWSSAQGSRMEMKQKLIHMQTSLQKRNHQPDDQGTSSQRADCRIAYTLHAYLMRNGSTTTGTFRHVMLFPTQEPQPPSCTSDFPGDYALSRSAVLRTAMLFRRLGQLSVETMEPAPLEMSRKKNGASTAIHLVLRFRESRERSKCESMSPPTPDFGAVSLKLKQMTFISVEPQRRLPATRDLLTSPLMAKDTEIIYEQLRKLKFSPWVRSRWKEEDGGISDQERRVWETKATLIFTYANGKRPAPTFSSALVSRRYSVRIAFRLERVYHGTLELEVPLQIIYRGDGQIPLSDESELGDSELASSDETLTLRSESQSTAVTLAAENEQAPDYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4R7</accession>
    <name>A0A179U4R7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine Rich Repeat domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02994">
        <property type="protein sequence ID" value="OAT02994"/>
        <property type="gene ID" value="BDCG_08900"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08900"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="485" mass="53776" checksum="D58EBB68013B701B" modified="2016-09-07" version="1">MSSQALPTANCQHQPHHQPDYFQKPVNYTRDISPSSGSESSRRPSFGSIKEDSTEIAQSFVDTEDSSSNKQTTKAGGKAAAKAVVQSSDSPEFCCPCGAFLGWKHIRLGGRRLSRSYSDLRLLGNAQSRGFAWEVNDSGPITPVQEEPKKTVRKGHAPIELLPAEILDQIISHLAIDIPPNGYTPRNIDLVSCLLTSRTLHSATLSVLYRHITIPHSIIFSKALNHIKQYPALGTIVRRLDFSHFTSVGLGRTQQMNVEIQNLTSKTLLECLELLTNLKECLLQEHLEDDVNVDVLRKLLSRTPSLRAVDFCGCSSAIFSNGFLSAVTEDFDFPATLPALRRVSLHECSGLIPRVFEVFLPRLVNVTHLDVCHTQITNSALMSIPHTARITHLNISRCTKLTGPEVVKFLTTHPATPTPGRDGRRHPPALPNLDPPLGEPGRGEDLLIEHALSSPPLQARRRTRSRFCQPYHQRHQPVLRTTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4S1</accession>
    <name>A0A179U4S1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01462">
        <property type="protein sequence ID" value="OAT01462"/>
        <property type="gene ID" value="BDCG_05258"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05258"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="284" mass="32124" checksum="1959CB25B9FA2281" modified="2016-09-07" version="1">MSSANESPPISVDSECDTSGDQIYGDDLSSFVQSLASTVITETYENDTILLEKAKESNRLDIVHYMMVTLCDEKLHLAPIGPSPQNILDIGAGTGIWCCEMGDEYPSAQILGVDLSAIRNTMHATPENVRFEIDDIESEWAFIDSFDYIHCRYMYAAIRDWPRLVERCFEHLTPGGWAEFQDFDVHWYSDDGSYDPKSALGRWFSLFYEAARQHGRELAPGPRLEGLVRGAGFTDVVVKKMRVPVGRWPKDPKLVRIRPLSSLYFSISFICLFIFVSLPPDLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5E8</accession>
    <name>A0A179U5E8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ulp1 protease, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002620575.1"/>
    <dbReference type="EnsemblFungi" id="OAT02211">
        <property type="protein sequence ID" value="OAT02211"/>
        <property type="gene ID" value="BDCG_07038"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07038"/>
    <dbReference type="eggNOG" id="KOG3246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="PTHR46468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ULP_PROTEASE" evidence="3">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="272" mass="31159" checksum="5E6E093A66BFC6F2" modified="2016-09-07" version="1">MGEGGFNRFKDRMRGRFGDSSSPDDAYLSYHDVRLTNEDIYTLKTDWLTDNVIAFWEEYLEREFLVNYQSANIVLLRPSMSFMLLQTPDPRTLRDVLPDFTKTSHIFLPINDCRNVNEAEGGTHWSLLLVSVVDGVAFHYDSLPPGNCDEALQATQKLSHLLNKQLRFINLDDSPVQENSSDCGVFVCLHMRHLLLKRLLMANSSEKISMSLRGMRVNANNGRKEIVRIIERFRKKGQRRRSSSVNASSNSNSNGTSDSQREKRSRSPPRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5F8</accession>
    <name>A0A179U5F8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_17639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02568">
        <property type="protein sequence ID" value="OAT02568"/>
        <property type="gene ID" value="BDCG_17639"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_17639"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107203" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="73" mass="7629" checksum="E44D463476286069" modified="2016-09-07" version="1">MLIVLIVRTIMMATSCHGRQAKTPCGASPSLVSLVCHGSGFHGLYMGLLPQGTLKVGGRWGDGPDGRPVGAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5G3</accession>
    <name>A0A179U5G3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_09514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999988">
        <property type="protein sequence ID" value="OAT03245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03245">
        <property type="protein sequence ID" value="OAT03245"/>
        <property type="gene ID" value="BDCG_09514"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09514"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="SSF57701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT03245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="649" mass="70833" checksum="B27F90935318412C" modified="2016-09-07" version="1">MSAVASVPAVNGNHDSNKDSNPEHSPSRFTAVNGRDQGALPSNSNNNNGNNSNNTGPSENNPTVAQNEEPSASATAERDRASRNSGTPARQPEQSLESANPTVQDPEATYVVSDGNSPNTNRNKRKRSESDERQTSPSSYQGHSVSRSPVSQPDHKLDPQIQGAPPNGTTHAQTASEADSVAKRARQSFATVPERSVSVQSTGNTSAWDSYDTQLTNHAQLGHQPIDSSDAQLAEALQRDVQGPDHAAKNWPTVPEGESADSTRKFTYSHTPPQERPIGPVQVGPKRKRVFSNRTKTGCMTCRRRKKKCDEQHPSCNNCLRGGFLCEGYSSRSTWQKPSTSKPPVPLQAKDGYSEVPPQYIPDMSPQRHDRAPTTIHTNNEQPKSDYHAALREMSHGASHQKPGMPVFQGNIEQRPKHQQPHVDTSSYPAQARLALNMEPHVAFETPKTEKEKMLAGEPYQNYFDPQLNRERERCKAALWRYNNASNPNLGISPDERRRLLKEVLIPPLDPQAEPGSNTPVGSLGPCAIVETPFNCHFGYNINIGEDVLISENCLLADDCPINIGAHTWIGPNVTILGSMAMGSMQDRKGSRSKYQGRPVVIAEDCWIGAGATILPGVSLGRGAYIAPGEVVKQQILPYGFQGLKPNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U661</accession>
    <name>A0A179U661_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02697">
        <property type="protein sequence ID" value="OAT02697"/>
        <property type="gene ID" value="BDCG_08112"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08112"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="PTHR21032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="288" mass="33295" checksum="D7F91D8BC64F3CFC" modified="2016-09-07" version="1">MMAKLGFKPGTALGKDRSPEYPSGIDEWNRPLTEPLNVVVKEDRGGIGMDSEKKRKIREQAELDTKRAKVEEGDFRERVRREREEKRTEAMFSAAQKVAERLDAEESEQEEEKQVDGQDQREDSPKEFVQKEAKLNSTPLHPSAASSSSRRQTKPTSQINILYRGLVRAREENLRNQQARRGLYQSLSTRNPALIPNLENLPTYSESDLDADDRLALGRTAEGEIVEVESDEDEDEELNEFNALSPQERLSRLVVYLREKYRYCFWCKYRYETDEMEGCPGLTEDDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6H1</accession>
    <name>A0A179U6H1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_08601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02888">
        <property type="protein sequence ID" value="OAT02888"/>
        <property type="gene ID" value="BDCG_08601"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08601"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="zf-GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT02888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="410" mass="45192" checksum="03B07AB80D7F9E0A" modified="2016-09-07" version="1">MGAGIMGGGVSFFYTCPKPQGKRCNFFLWEDEAEIRERDMAKVLKGAGTGAAGGRSTNRTPSRPLAQASIDARTGLLTPNTGTRKRARDYEQGYGYGLTSVSEMGSPSKKSRMEDVVVKREEERKDDDTDDDSFGWDEDIEGSVVEQLAPREDSHLEQQRQKQGKGQGIFQPGTRRKSPGWFRDGRGLFVSEDEDEGVRDDGEDGSPHGQRDTDPAGLDGPFFPTPSSRVFRPYHSPSASLSRFSTPQTTRSTLTYGQDTATTSSRTTVVDPFDLDPPQTPTPIRFNSFPLLRRDNQQEPHGTAPPIISSTTTTTSTTSPQKTGTIVSNTLALLSKHNIHMPPAAKRELVGLLNAEYLHTQSIIKGRDATSAAVRNRDVQIQALRGRIELLEAEREGFRLGRRSRDFGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6H6</accession>
    <name>A0A179U6H6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat and BTB/POZ domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02112">
        <property type="protein sequence ID" value="OAT02112"/>
        <property type="gene ID" value="BDCG_06808"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06808"/>
    <dbReference type="OMA" id="LQYDYSK"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="PTHR46231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="184"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="504" mass="56939" checksum="AFF42820CF500812" modified="2016-09-07" version="1">MVKSWKLPSSIPPEAFNVGVRYLYLGEAPRELRFGPGTDYTEAEILAGIERVAKHLQLPGLVETILDSGDRRLTRQRRAEETSRGRDQMESWFRENVLQHKLVVETDKANKVKWPRDNGIFADVLLRVDEPVAEDNMPRTNDGTHELNPGNLEATNRIPVGPTSRPSSPTSWPPSQKPRKSILFPVHRAMLLRSDFFNAMFSSTFKEAQITEHLQIIPVDCSPETLEVVLTYLYTDRVEFPLSLGVEVLCAADLLCIERLKSKAAVLISSLGNGNMKQQQARREDEKVAKETDATPKETQQDDDEEELDIYEVIRAGWMFRVQRLEEFAARYLAYRLESHIDLPEFAELVAESATRISQRQETDSIELVDDIRFYLSERFRLRFEDSGLDEIMMDENPKVTQVGDGSSGEAVDGVKVDNDISNDNLTADIPNRGSESERDSAEDEATDVSNHKSQPVNGFPSNGAVFRTLDGHVAGDEFARDNADYQILLDKLDRLLEKLGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6J2</accession>
    <name>A0A179U6J2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_08716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02929">
        <property type="protein sequence ID" value="OAT02929"/>
        <property type="gene ID" value="BDCG_08716"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08716"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="216" mass="24113" checksum="21A7D1EECA795941" modified="2016-09-07" version="1">MRKVGLNYTVPALDVNLQEVREVFETNFISVIAMCQEFAPLIIKAKGTIVQVGSVAGIIPYVFGSVYNASKAALHSFSDTLRVELAPFGVQVTTIVTGGVKSNIARTSRTLPETSLYHPVAAEYARRIVHSQEGAVSNEAYARTVVTQILYGSAPLRWLRWLLLWPFGGRGIRRSGRYVWAGNRSALIWLLSGGWAWFGVFQMGMSRMFNLWKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6J8</accession>
    <name>A0A179U6J8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_06839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02132">
        <property type="protein sequence ID" value="OAT02132"/>
        <property type="gene ID" value="BDCG_06839"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06839"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT02132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="217" mass="24785" checksum="5E96367DB778F33E" modified="2016-09-07" version="1">MLRATNSYFRNLPSDIEVARIRRDYVADLVRAETKEVVDAATSATSEFPSISIGDDGRSASPQRLTCYSCLRYLPIHSFSSTQTTRRRGKGHADAAKRFCVSCALRLRKWEPGITLSFSWGEAVYCRRCRNLMPLRESAAEWARIFGLCEGCRTVLGIPDWHQHEGKGAQGFWYGAKELLDRTFAERGRGRESERVDMWEELKEKIAVLRLSEELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U773</accession>
    <name>A0A179U773_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_09287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03159">
        <property type="protein sequence ID" value="OAT03159"/>
        <property type="gene ID" value="BDCG_09287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09287"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT03159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="327" mass="37562" checksum="9AC9F26F8325468A" modified="2016-09-07" version="1">MLVDVTEKIGDVISRRQQSTLEEELRQQPSNSVRIAFAGMKKDCEKWIANNPNAITKLPIPHQFWATCTEDLNGCSNAIYSHGGYGELVNLDTWSCFKLKEASSDKKYVWYQMTMFIRWNPIKQTTFIFCSDFLQCLRDGLNRRISSVGPSDPFTWHASFVDELRLLYDNFFWKFRNLVRDAEKERNEPQATGPNFPRLHDIARHVIHSVEILDVAIETVDSILHEHDLFISNEGSTVAFPIPDLKANDVTRRLYYHSRELRAIKARSASLYDRLKNEISLSFNLVSQTDTAAMKIISAVGLIFLPGTFISASLTSTYVYYVQPFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U780</accession>
    <name>A0A179U780_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02352">
        <property type="protein sequence ID" value="OAT02352"/>
        <property type="gene ID" value="BDCG_07323"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07323"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046907">
        <property type="term" value="P:intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="PTHR23138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="476"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="655" mass="69821" checksum="1E10BCB172B9B76C" modified="2016-09-07" version="1">MASETHQENGVLNDEPASRTPSAAIFPEPHSTALDTAEHTDKDSQGPVSGSNTDDVGASPGARPTPQQGSTHLKQENHEPTPENDVAELSEDGAGERPVRQKLKETSIAGVPRPNSPEDHAMASQVASVAGADSVNETSSVEARGRLWRKRSRGDMNEDENQDDISGVTNTDETGHRRKRSRDSKTDDQSSDNQGQPKSGIRTPTEELKSTERDAANRILSPKKKRSRDQFDKDHLKSDALDEKCQEGPASAKTGESFDRPKAVSANRTVEGEPEKKRHRDDSQDRSSQGDSDLVSKKASAPNPFSNTLGVSPFASMSSKPTQLTSKGTTEKKEQPMTSASAFASSKLASFASSEKSPFSSLGGGSTIGLKSASPTENTTVNKPPQTSSSAFAASPFAAAAASSPFGAFGGGKSAFSRSGFGTGFSAATPKLGGGLAGFAASTTGGSAILGAAGSKHGDEKNVEKGRKGGDDGKSTFEGLEEEKGDERFHEQQTETGEEGEDTIFSCRGKLYHFDGKEWKERGVGVFKVNIREPANGDDDTDESSEEQQPLEDKVEEKEEKEGVKAKTDEDDNNEPKKKTARVIMRADGVWRVILNIPIFKGMKAGDPSGAAPKGKQVHFAGFEEGKSVPFLFRTGNEDVAKELCVTIQKLQESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7X2</accession>
    <name>A0A179U7X2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein gcs1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002625231.1"/>
    <dbReference type="EnsemblFungi" id="OAT02612">
        <property type="protein sequence ID" value="OAT02612"/>
        <property type="gene ID" value="BDCG_07866"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07866"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="413" mass="42444" checksum="82A4EA3ACC8EF3A9" modified="2016-09-07" version="1">MSKIWEVDPETRGKLLLIQKTKGNDRCCDCGAPSPQWASPKFGTFICLNCAGTHRGLGVHISFVRSITMDAFKLGETQRMELGGNEAWKLFFDEHAANVAEGRTFEDSTIKERYDGDVGDEWKARLTAKVEGREYVPGEEKKMQTSRASTPSVSVSSSGKGKAPGGSISPEALGAGKKERNEAYFASLGGENANRPENVAPSQGGRFTGFGGGMPPPSASTRNEQDGNGVIPGLNDFQNDPVAALTKGLGWFATTVGKGAKTVNDSYLQPAAKTLAETDLAAQARLAAAEVSRNVATGTRGAADALTRFVEGPPSSGSASGGSGSAFGSQRRTLEPERKDFWDDFAALGEERRRSGAIGTTAMRGGGGVGGSGGGGAPSGGGTGAGAGAGTGSCGTGTTGKDDGGGGGWDDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>C5G8A7</accession>
    <name>C5G8A7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="EEQ83613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ83613">
        <property type="protein sequence ID" value="EEQ83613"/>
        <property type="gene ID" value="BDCG_00418"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00418"/>
    <dbReference type="HOGENOM" id="CLU_020924_0_0_1"/>
    <dbReference type="OMA" id="VLDPYPE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ83613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="550" mass="60217" checksum="EE5FDFB37D0BE70D" modified="2009-07-28" version="1">MGIPLHWEPPARSAAASNGRAKADPLAPSRSTIRRQRTLRRPHRNNNGSRSASSNRPAGYVPSRPSMPQWVESLSREALGDSATSSTATARGSAMTTGEPGASRYTPSQDNETRLDWPASSSYSSSQTRRDLGDQIPRTTALRYYSSPGGRRIRIPRESSLRFEMLHPPSWSHSTERSRRSELSSDATANSRLESRLGEIVSFSPRFAPAYPPRSNGRAMVSSDSYDPNMPLLRRVGHRSVADTSDLDATRPRHIIDGLGDRDRSLSPGGDSQHDDEDSHYHDHDDDDDDDDDDEPNMWESLFTTITPDQHLPSLDSSFTSATASASTAPSRNSANSSQSTLPSSLGANNSNPSRRPGVFPPLESFTDHNNHCDFFSSSEDSETEPDSDNEHIPTWRLMQYDDPMPISSSVSAIDDAIRRSEQQQQLRRRYQENLLGITQTIRAVVAETPANRNGDHNTTTNINTSTNATSSFTSSSTTPTSINVSFGQSSSMGDLQQVQTIIDQLTRRQDIGDDWWAAVGLSRNLGRGVTDVPARNGSGNSGSGDAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>C5GA29</accession>
    <name>C5GA29_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_00956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="EEQ84151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ84151">
        <property type="protein sequence ID" value="EEQ84151"/>
        <property type="gene ID" value="BDCG_00956"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00956"/>
    <dbReference type="HOGENOM" id="CLU_1805650_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ84151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="143" mass="16181" checksum="B8C8B001166DD7E2" modified="2009-07-28" version="1">MHKPGSHAWQGPESSFAFILPSFVHQPYRATRNGCLQMDPDGVIGALLININKVETSSFWAARRETDPHDPSHTLDVTHSTCGQIHQHREVTARHLQIAPKLHRWMDSWLPLLLLGPDSRFSISCIAFYPLFLSLRFSSQTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>C5GAQ4</accession>
    <name>C5GAQ4_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_02135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="EEQ87015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002625698.1"/>
    <dbReference type="EnsemblFungi" id="EEQ87015">
        <property type="protein sequence ID" value="EEQ87015"/>
        <property type="gene ID" value="BDCG_02135"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02135"/>
    <dbReference type="eggNOG" id="ENOG502QTEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005258_0_0_1"/>
    <dbReference type="OMA" id="YVKFGKW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urb2" evidence="3">
        <location>
            <begin position="1255"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ87015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1489" mass="166790" checksum="E225D4D28EB8C203" modified="2009-07-28" version="1">MAPVLESPPSAHQALLELEKGTSGPASQLQEAARIIGVDLSSSYSREKLDIRVVPDAEKENQKHSAPKEEWVLRWLMKKLKGSSQQHEQLQSKYYRLDTKTWILLQQLFDRIPTKPLAFVLNENKFLLILKDVLGAISDASNSCPERPALQESLHSESSVTVQESPVSGPSKRGQKRKRAENGLDSVVPVGGFAGSWVDTFCTVLDSVKALVSLPDQVSGVRSTANSQLKLVLRGEPQIAATILGQSLELARKVVEERDRGCVELDAQLMPALPSVLEIWRLSSERLGDATNLSSDDPFSSHCLSEALHLLMALREIRTESPEKTNVIQNLERIVVLQFVLPLRQSFFSTYSTETINSNHSPDSTQIKRVLKDIHSRWKKSNHSSNIKLLPTLLDIAVRSVPRDTFRRQVYEAPWLETLFVALSTIAGCPPVDGMSWSTPHRDIPILERLLQVILEREVSLSINTVSRYAIRFSGLVENEAYQATEWSLISKIIRTGVDVFLPNSGIDGTENLLSNLIGRITSFSLVSSIMPNETYGVIKNDVVIPLLKGFAGARAIGSFLNIWSDQLTWIESTRLGGADILYFFVWEDDDLAAAFRPLITDLFSENQTKDRLQTILTQHSFDDEAKISEYYADIVLLDAILKPQLREGDAMLEGESLAQAFGIISNLILSRWKLDWGWRLWRLSQRFVNRLSSYTDDSSMDLSRALLPKAVDLLQSFHNQGSTTNISTNDCLEAFEAFKLVVLVAGRADSAKHSQYLNEIIPRIAPAFNQVVKSAGPAWDGRVDTMTSPEAVCVGYLVVLQATPLAVSRLTSENRALLFNGLLTSVERSELYTSTPLSRQETVGSSLESQLVEIWQSMTSNEWLLETPAAVYDLVNTILHHLKEKNSPRHLSIASLLSVPTRLIPRHQRGMLLDFLQQTIVTGQLSSGPLCTDILTLMTRLADLPKSSAQITSDWEEPWKLSNAISLSMGDSSSTVLPFQPFRQLHKVIIDRVLVSSDAQRHLYFQKTFDKASSMVQKYDNANFNNMEFSMLVLSLGTLRTHHEHLGGNLKVETLNALREKVLNILISDLRSIEKNMEKDREMLDVNTLTGILNALEDFEDMMKTNKEAQKAIRKVEKRLTTVSDDIHTKRLAKRRLVSSQQPGKDLEHVLMQSLSLFPIDQLYGEEQQMLLRDIRHKLSALSEKKLVRLVRQIRESGFAGQNTAHRLLLTGVAISCFEPVEDPDTQASQELSALFTALLQCLIETTAIEPFSLATECIEMLLRNRSRSITQWNIDNTLGTIAIVISTQGPKIAGKYAGVIYSRICHLLGLVFGQYRQKLSGRFHLVLPVMQPLLRLLFTLSSRPQRSSRSQLTPPPWADSHNASSLLHKPSHATQFTRLLTTLCDPTVSAVQRVQRSDSGLTDNTKKVKSLAGQHLQYLVMEYAICQLRGQLAPEMKAALIPGFYSVLDAMSKETMRGMNAAMDSSSRAVFKSLYEDYVRFGKWNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>C5GCT1</accession>
    <name>C5GCT1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">High nitrogen upregulated cytochrome P450 monooxygenase 1, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="EEQ86309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ86309">
        <property type="protein sequence ID" value="EEQ86309"/>
        <property type="gene ID" value="BDCG_01429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01429"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OMA" id="RDKAFHS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ86309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="561" mass="62368" checksum="D428361F6EE1F8D6" modified="2009-07-28" version="1">MLQLACTAGIALGILSHLLLFKHGEWDRYAPTLVLFYAFAMSVLSPVVVFILMELSMLSTLLLVSTFWISYMTGLFGSIGLYRGWLHRLTQFPGPVAWKLSSFGSIKASVGEFKFPVKVQQLHETYGDFVRIRPREISINHVDAVRDIHGPGTTCVKGPFYDITYPFRSLQMLRDKGAHSRRRRIWDRGLGIKALTTYEPKILGHCADLISQLSAKSKGGKPIHIGPWMNYFGFDVIGDVAFSKPFNMVKDGKAAEILEDFLTSKPALGTLICAPWTFNLVQNLPGLRRLWEARTKNHARKIAERMKLGTTCKDLFSYLLEDGPASPAASAPLVFSEFSVPGDLACDSELAITAGSDTVAATLTSLIYILATHPDKQTLLQQELDTLLTGIADISYQKLSVPNNAPMLEGVILETLRLYPGTPGGMQRMTPPEGARIAGRWIPGNTLVSTPTYTLHRDPRNFDQPTTFIPERWSSTPNLIKHKEAFNPFLIGANSCAGKAIALMELRFVTALIFRKFTVRLHTANAAKSSPLSFFDEQKPGWRDYFTASPPPFEVVLERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>C5GI67</accession>
    <name>C5GI67_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_04453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="EEQ89333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002628525.1"/>
    <dbReference type="EnsemblFungi" id="EEQ89333">
        <property type="protein sequence ID" value="EEQ89333"/>
        <property type="gene ID" value="BDCG_04453"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04453"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011125_1_1_1"/>
    <dbReference type="OMA" id="WLKGPDP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="SSF69848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="201"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ89333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="683" mass="75081" checksum="0598C3C5491F2C20" modified="2009-07-28" version="1">MAREPWDDEEALSGRTVITTLTDDEDDPYTDEPDGIQQLGMSGGVESAPTTLPIPVWLAESSKSFHWKWVPLPLRKAARSTVKWLKGPNPPRVLLLNPLFPSIQAMPVKLVDRFFPKRKYKIGLLLAVYFTWFLPWALVLRNSASGGHIEGYGKPAPISCGASYWAKGNECGLNGSHLVLEPYVVGNETVNYQALVVGGPIPGASSDDLEGAIYRADSHVCQAAIHAGVISDSTGGCGVVELTGAGHSYFASKANKLASVGFPSTFPKSFRFLRLPGSQSDCPGDLRWPLFAITATAIVLISLFTTSPAVFFFTTFFMLILHVGLVSDPPELHRVADLFSLLCSRLLPASFIAYVLYIYCARPLLEPLASPPVYQFSKTILYLGPAFVGALNNYTFALWIPIQRLTPHDIKAQPGAPIALAIMITIIVSIVLGQAWHIRQGGQFFHYLKIYLCIGAGLIFLLVLPQFRLRIHHYILAMLLMPGTAFPIRPSIIYQGLLLGLFVNGVARWGFASIIETPSALGELPGPGSNGWWGATSPNITNSSVHISLPSGDHVDRGNGNITFQLWEPERMEKLNVDGISVLVNDVERWRGFVDEDVTGEFVWHRQGHRGLDMSRPKRAGVEEYEHDDDTVISMQDQDGNEDPAEDLFFRFAFLKGSKVGLYGGVGVWNRDGSWISPPPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>C5GMK2</accession>
    <name>C5GMK2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_05427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="EEQ90307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ90307">
        <property type="protein sequence ID" value="EEQ90307"/>
        <property type="gene ID" value="BDCG_05427"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05427"/>
    <dbReference type="eggNOG" id="ENOG502SPRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036934_2_0_1"/>
    <dbReference type="OMA" id="LFLERCC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="SSF57959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EEQ90307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="388" mass="43077" checksum="BD2A50EEB7EF2607" modified="2009-07-28" version="1">MSATLQKTAAAASSSPSPNPYYHDTLDSLWTKTKEKLHISRKQAVDEENNQEAEGAGVDYDTLKSAHARRREQVRRAQRNHRERKEKYIKSLEQELSRLRDESSSIQTETYQVAEENSILRDIMLAHGIALPGTGISHSRPQDQWLYNNPMATVSVIGSPGFGQRLEVSLGGAPVERVFPPGFGIPESPPEGKSQLSVVDHSKRGMVPKDGAQPQPSLSPPAGFNGSDRLASTRLPSQPLQTPRHPYGLDSTQVGVDFVLFMERCCIYHVHQPQDREEPHGHAMTALAPVLNQAPQSLDDCTTWQIPSCELDRLLELSSALELDGELTPVQMWARIKQHPLFHKLDPEGLRKLSNALVAGVQCFGFGATFEEQFFTKTVDEFLGALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>C5GQ12</accession>
    <name>C5GQ12_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PRO41 protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="EEQ91539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ91539">
        <property type="protein sequence ID" value="EEQ91539"/>
        <property type="gene ID" value="BDCG_06659"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06659"/>
    <dbReference type="eggNOG" id="ENOG502S16N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132815_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002952300" evidence="2">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ91539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="145" mass="16405" checksum="377B4E645D37F35C" modified="2009-07-28" version="1">MGKLIKNHWARLIILTAAAHQCAAGVHGFFWPKVFWDFLTKNLDGAVKPVPVLQILNLLFGLLCLAWEWPLKPLAGTAMHRSIEIRLLVFPISTLCAILLYQGTNSALYYLIGMVVYFWAYSEGEVVCAEPWTLPRRIRPGQPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5GRT5</accession>
    <name>C5GRT5_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_07397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 4"/>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="EEQ92277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ92277">
        <property type="protein sequence ID" value="EEQ92277"/>
        <property type="gene ID" value="BDCG_07397"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07397"/>
    <dbReference type="HOGENOM" id="CLU_013615_8_1_1"/>
    <dbReference type="OMA" id="KTHVVEC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PTHR45779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002950255" description="Peptidylprolyl isomerase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ92277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="140" mass="15266" checksum="2A4D8196C99DE37A" modified="2009-07-28" version="1">MRVQSLVTFLSLSLFSLTTFVVAEESGLKIEKTHTVECERRTTVGDVVSMHYRGTLASDGSQFDASYDRGQPLVFTVGKGQVIKGWDQGLLDMCVGDKRKLTIPPGLAYGDRSVGPIPGRATLIFETELVNIQGTAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>C5GUM4</accession>
    <name>C5GUM4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Udp-galactose transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_08293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="EEQ85024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626439.1"/>
    <dbReference type="EnsemblFungi" id="EEQ85024">
        <property type="protein sequence ID" value="EEQ85024"/>
        <property type="gene ID" value="BDCG_08293"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08293"/>
    <dbReference type="HOGENOM" id="CLU_024645_2_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="PTHR10231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EEQ85024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="456" mass="48937" checksum="79C652A8BAC60F41" modified="2009-07-28" version="1">MPVVGGRRYLSSTAVFLNEVIKLAVCLTAALYEVSKTVPPSMPATSLFTNLSAAVFTGDSWKLAVPAGLYTLSNSLVYIGLSNLEAATFQVTYQLKLATAAIFGATLLRRSLSFGKWTALFLLIAGVFIVQLPHTDPNDMHDHRTRVRFPRSLEEWQNLGASTTRRNVHQQPHKRSATYEGIEEDLMLGFPHMNGNIGLLATIGACIASGLAGVTFEKVLKDSATSTTSVWIRNVQLAVYSIFPSLFIGVVFLDGEKVARAGFFGGYNWVVWLVIGLQAGGGIATSYCISRGEHGLRNSATGISIVLSAVGAMWAFEFRASGNFIIGTILVLAGTYIYNQLPHPSTPRTPPKSNNRPPPIRINNFEKLSGLGMVTSTTSTTSASSAADAGRNNNNSTTTTLNHANAEYSHLTPSNDFSIKLPTTPGLSESAALTTSRPGSPNHTRLKGSYFAQRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C5GUX8</accession>
    <name>C5GUX8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_08072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="EEQ84803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ84803">
        <property type="protein sequence ID" value="EEQ84803"/>
        <property type="gene ID" value="BDCG_08072"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08072"/>
    <dbReference type="HOGENOM" id="CLU_045717_0_2_1"/>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="177"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EEQ84803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="316" mass="34340" checksum="ABF97C4CCB8FB82B" modified="2009-07-28" version="1">MSIPRAIRTAFVAVEQAEGAGARVRRSIGTPKLRNFSPFLLLDHFTVGSGAGFPDHPHRGQETITYLLSGGVDHEDFAGHEGTIGPGDLQFMTAGRGIMHAEMPHENPDGSPNVGMQLWVDLPEKLKMCEPRYRDLRAAEIPVADVDEGKVSVKVISGQSHGVDSVRDLAYTPVWIFDITMRPGGKISQLLPQGWNSFAYTLSGTTRFGAASESTNTAPPSSLADSSPAKTVGPFHNVVFDQPGDFVQASNAAEAKEDSRFMLIAGQPLNQKIVQYGPFVLNSQEQVQQAMIDFQSNSNGFERARGWRSEIGKRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>C5GUZ0</accession>
    <name>C5GUZ0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_08084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="EEQ84815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ84815">
        <property type="protein sequence ID" value="EEQ84815"/>
        <property type="gene ID" value="BDCG_08084"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08084"/>
    <dbReference type="HOGENOM" id="CLU_1895615_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EEQ84815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="133" mass="15021" checksum="A07279454E42B5EF" modified="2009-07-28" version="1">MLKGVCTQQNEQQQELRVVISLCMKKAYGMLAVVLRYPTAYVVGREGSSDSWSKMAQADKSSQKIRAALSEHNYPSPRNILIIPSDMERVAWIDFDVENTYPGSTYIRASERVLKSSLKLKVLSDFGQMLVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C5GXU1</accession>
    <name>C5GXU1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_09142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="4"/>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="EEQ85873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002620244.1"/>
    <dbReference type="EnsemblFungi" id="EEQ85873">
        <property type="protein sequence ID" value="EEQ85873"/>
        <property type="gene ID" value="BDCG_09142"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09142"/>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="OMA" id="FGCAVEL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="9">
        <location>
            <begin position="148"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EEQ85873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="330" mass="34444" checksum="47B6FD0DF16BF630" modified="2009-07-28" version="1">MVKAVVLGASGGIGQPLSLLLKASPLVDQLALYDVVNTPGVAADLSHISSIATVKGYLPKDDGLKDALTGADVVVIPAGIPRKPGMTRDDLFKVNAGIVQTLVKGIAEHSPKAFILIISNPVNSTVPIAAEVLKAAGVFDPKRLFGVTTLDVVRAETFTQEFTGQKDPSKTTIPVIGGHSGETIVPLFSQAKPAVNIPADRYDALVNRVQFGGDEVVKAKDGAGSATLSMAYAGFRFAESIIKASTGEKGIVEPTYVYLPGVEGGDAIKSKVGLDFFSIPVELGTSGAEKAQNILGDITEQEKKLLEVCIKGLKGNIEKGVEFAQSPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TU07</accession>
    <name>A0A179TU07_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_16068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
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        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99355">
        <property type="protein sequence ID" value="OAS99355"/>
        <property type="gene ID" value="BDCG_00247"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00247"/>
    <dbReference type="OMA" id="YVFVMGR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ACAS_N" evidence="5">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="76"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="4">
        <location>
            <begin position="549"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAS99355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="709" mass="77524" checksum="302E2B0707B15835" modified="2016-09-07" version="1">MASHPQDRTQSLSLRSLKKFWSHHAAQLHWHKPPSASLRRGTKTLPASGISHEHWSWFPDGEISTTYNCVDRHVLSGHGDNVAIIYESPVTGVKGRYTYAQLLDEVEVLAGVLREEGVRRGDVVLIYTALFAALAITRLGAVHAAVFGGFAATSLAQRIEASKPRAIMTASCGIEGSKGVVNYRPLVEGAIAKSSWKPQKVIVWQRDQLRWKPMLKLEGQRNWQRIVKSGRGRNIRAAPVPVKSNEALYIIYTSGTTGLPKGVIREAGGHAVGLNLSIKYLFDIKGPGDVMFCASDIGWVVGHSYILYAPLLAGATTVLYEGKPVGTPDAGSFWRIIEEHRVNAFFTAPTALRAIRKEDPEGRYFELVGKRGGLKHLRGLFLAGERSEPTLIRAYQNLLDKYAAPGAMVIDNWWSSESGSPMTGLALRSAIGLDQGSREETHKPFPVKAGSAGKPMPGFDVRIVDDEGDEVPNGTMGNIVLAMPLAPTAFTTLFNDDERFYKGYLKRFAGRWVDTGDTGMVDDEGYVHVMARSDDIINVAAHRFSTGAIEQAILSHPDIAEASVVGIPDPVKGHLPFAFVQLRKTSASSNSNSNSPIPATPPPALFTSVNNLVRGQIGAIASLGGMIQSGGEGKGMIPKTRSGKTLRRVLRELVENAVEKGDFERAVNVPATVEDVEVIEVARGRVREYFVEREKREREKKERVGWAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TU56</accession>
    <name>A0A179TU56_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_16099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99383">
        <property type="protein sequence ID" value="OAS99383"/>
        <property type="gene ID" value="BDCG_16099"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16099"/>
    <dbReference type="OMA" id="GWQRITF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="472" mass="53832" checksum="C0DC1CE3F5603AF6" modified="2016-09-07" version="1">MIAMLVELEDVDMCRMARTCRYFAEAIIPPNSGVWRRRFLQKYDHPPPDKSSEEVRVEYKVRSIMLAQTPSFRDGEGRKEKLWLSVLTTLFAESYNTQPSRQGDEMRVSRNRACIKKAIRSSGFLDQPIVGDGANSSLPPSRPYLAIQLAATYLVLDINHSFRSLRTDYDLNIVYRCDSSTPDIPIINASNDEENIDLYQLLHIRNFWKRHLRNRDENTFHKSYHNIPKIMRPKAWEEGLGNKGSLGTCWLGYYSCIHPLPISSTDLQERQTCADLMSHWESTSALLLKLPTLTTNASISTTWFPLFNEAYPINTNVEPSSRTYFRGTQSLNLDQNHHHHHHHHHDAHDDAHDSNDQPHPNSMRGFTEPCPAQAGIPGWRRICFIIYEINPEFFVSAADDNDNGDGGGGGGGGEGDEEVEGWLPWSWTAVDFLWAYGYEGVIVPGGGIMMGRWRNMMVEAEVEEGPFVFWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUT4</accession>
    <name>A0A179TUT4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99269">
        <property type="protein sequence ID" value="OAS99269"/>
        <property type="gene ID" value="BDCG_00060"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00060"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1328" mass="143568" checksum="BFADC22D076511B8" modified="2016-09-07" version="1">MAEQSSHDVVNQTRSGGEISPSDVPANKPDNINAGEDAGGFKQQNSNNDNDSNDNNNDSKSEQRADPKTQERAHDTPETRNDGKPAINGLGETSHTGDDRLSPLQLGDASGGSDTDTSRTDLRSSADRSQHIRTNSVKRTSVFKPVSYAKFSVTKSPGPLQTSKASADKTSFASASSTPSVSQPAKPRLVAKSTGGLRDSTPKLTGIGSKSGNGGPDPNQVWNKNRPVQPPTKHLTDEELKKQYGIHMTSRIQEDGNGTEAKWADIDDDEDDWAPEVIEWNDGTKIKLTQTENVPLPGEKEKDTTKDRKPSPPSLESRSKLLLSKTSSAGPNATVLKLGAGADKQHRSGETKGHNEKPTLTSRAQSAAHRSPWAPLPPIDKVPPVTINPPLPGPPTRFSQRDPHGHAPGPATSGPAKEIAADDFNRSWRDTHSSAPRELYNSQSGRYEPVLDTRRGPARIEANFRPPSLLQRPTHEQPNLAEPSPTFQSRGSAADGASWGRRRTSSNVSGGSGAFGRRMSLGKTPVNGVNERPSSPLPHQRGPYPSRGISPSQPSTRQNRAGPPSTHYAPPGFHGGAPQQSGPPVTDETAQQQVPFEDPIAMQQRIMREKRELARQRRKEEEEREEAAKQERIRLKLQAMGVPPEKPSEKTPEKHSDRPSEKPAVEESSAPSELSKQAAGGTGYSPPKPPPVPEPSGEPKQYGMMKVHHPASAKKLVAASERGPDRSFANNQPRQPPSPSRDSKLESARSLPTNVNGVRPSTESSPTESRHESILDEKPPQWKGPLAGTATYTSWSGQNLSSHPPPTSSLWGPLSNDKALGNGTFDRNLTGFPSRDLPLTIGLPPTADRLGSTERPQPMVDNGRPLSPLASPQERPSRLAINEPLKPIARPTPIGPPSSHTQPQRWQNDQVSRRSQDAAGWNDFHTVAAKAELDGGENFHREFAALRDEETRSGLSPASLQVSFNETWRQVENDPTGQRHGTTRTNDRGASLPPLHGFPPAVPPLPFSDVSTKTLPNATGRESRFFPPGGDQLRRPANIPNIYPQSPSPPPPDDISSHPVFTGDSNRPLVHLPTPKPRVKLPPRQTSPPPPPATFASMAAAPAVRPPPQLIANTTSWQDRFNGLFGKKPSPGKTYALAVTSATKEPLEVQPSTSPASVSFPQYDEMELLRDAGRATSKDVEDEEAIFEDREAGSTPVVKLPIIAPKAAWLPALPPPHSRLRPKYQKPVQPLSIEPYIAGFFDDDNTSVIIHLPGGDAAKTLMLPKKGGNTPPRPRGPSTFKQRKNAKPRDGSGNYSHSHASRKHPHSSTQRAAQSSGSWANRASNTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TUU1</accession>
    <name>A0A179TUU1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99643">
        <property type="protein sequence ID" value="OAS99643"/>
        <property type="gene ID" value="BDCG_00946"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00946"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="PTHR12303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="355" mass="39559" checksum="2BEBD74166EBD181" modified="2016-09-07" version="1">MLAKPPFSILDNFNQVDDAIDANAEIASAILSFGLKAFGLPANPDANDGHRNWHDNATGSDIGKAHSTVRQLYRDWSAEGAPEREACYKPVMTDLEELFGSQPRIKVLVPGAGLGRLIFDLCAAGYYAEGNEISYHQLLASNWALNHTERTNEYPLYPFALQFSNLKSRKQQLKKVMIPDVHPASVIAAQLNEPDNGRGMGSMSMSAADFVVQYSSPSQKAVFHAVATVFFIDTAPNLIRYIETIRNCLQPGGYWINIGPLLWHWEDRPFKNDSSQEDSPSKEATASDKRHEGIGEPGRVELTEEDVIALIQQFGFEFVKREAAETLCGYIQDPDSMLQNLYRPAHWVVKRVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TV38</accession>
    <name>A0A179TV38_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_16276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99715">
        <property type="protein sequence ID" value="OAS99715"/>
        <property type="gene ID" value="BDCG_16276"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16276"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP2" evidence="2">
        <location>
            <begin position="187"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="647" mass="72794" checksum="C2F16CF27E24EA7B" modified="2016-09-07" version="1">MFRNRNNSQQPNKELYSDFKRSYPDPSCWNASPLLAATQKAWIYPFINQIGHSRLVKDSDIKDHGLAISKLLDQWEIISAPLDLSSLSTSTSRTGGMAAASDPIFLPTPGPFLANPGVVDPRALQLKLCQLQFNETKHVKNPPADPDSFVLQNSEHGPVDRHSDLNAHVNQPQSREVAALMPGLTEHIDLDINKDNDKFRYNVTLCAPTAMVEHKGEVPITYLSKGHVYHMSVVDSTPPKSSTHPIKYRTYVHVAFEDPEKRLNPDPCWQLWKERRGLSEASRRGGKVQAVEYINPNQGRDRKARPSEVELETTSLNGFCVSWTSCTEAKSIGCTILIRLNFLSTDFNLAKGVKGVPVRLCVRTEMVYPANIYSALDTMKIYYYCKVKVFRDYGAERKLSNDIAHVRKAIHKLQQRISHEETKAHDFGKRKRDASSMTIEPENRPAKISKNYDAKARSGKERLLLEVAMKQDMISSTSPVSLLNLREDNQDTVDFSAAFVLNETQKSESELFTHQADGTFLPTIYMEAGTLDTSSSTPRDDYVNSPLQACRREQSTFRNSSIDVDFQHGLTDWSRILRLRSENQLLTAQMAPPAQPINMQNLFFEKLNGRIEAVDIDATCSLSSRHLAKSGDCLLLCSIATYGHSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVS8</accession>
    <name>A0A179TVS8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-RNA splicing factor Srp2, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_00694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002623513.1"/>
    <dbReference type="EnsemblFungi" id="OAS99532">
        <property type="protein sequence ID" value="OAS99532"/>
        <property type="gene ID" value="BDCG_00694"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00694"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="102"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="298" mass="34474" checksum="197BE756B6EAB9CE" modified="2016-09-07" version="1">MTEVSSTRLYLGNLPRNVTKQEIEDHFNSHHGSGKITEIKLMSGFGFIEYEDAMDAKDVVPDGTDFKGERLTVQFARGPRHKETFSGPSDRSSAPRPRRTIYRMQISGLPETSWQDLKDFARQSGLDVVYSETGHDGRGFVEFETGSDLKTAVEKLDGREFKGSRVLCTQDIQSLEDRQSRDPYRSRSPGRRGGYHPYDDYDRRGAPRGGYSPRNHYRERSPGRRDYYDRDGYGRRTPPPRSRMDDYPPPPRRPYDDPYDPRGPPPPRHYDDPYAPRPYGRPRSPPPRGDYGYDRRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVT0</accession>
    <name>A0A179TVT0_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_01559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99914">
        <property type="protein sequence ID" value="OAS99914"/>
        <property type="gene ID" value="BDCG_01559"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01559"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAS99914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="296" mass="32205" checksum="6E53AC71CD81D74D" modified="2016-09-07" version="1">MVSVHMGDKQRQYSANKYKKKKKQNKTVNWEHPETLEQGYDYNTLLYRMREKFPSPTYLLTTALSAGQWVLNKINLVEAHLYVDLINLMTYDFSGPWMPHSGHHAQLYAPPPPPQPAPSGVPGPPQTAAATNSTCTMSCSSGVAYLLSWGVPADKILLGIPAYGRAFPGAYGINQPYDRGGEEKVFDYRELPLPGTEEVHDDVVGAAYCVDVGGGGGGGGGGGGGGGAGFISYDSPRTVTQKAHFVSEFGLGGLFYWHIATDAGVETRRSLVATGYCALHPWMISTSNERRWGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVU1</accession>
    <name>A0A179TVU1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99923">
        <property type="protein sequence ID" value="OAS99923"/>
        <property type="gene ID" value="BDCG_01572"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99924">
        <property type="protein sequence ID" value="OAS99924"/>
        <property type="gene ID" value="BDCG_01572"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01572"/>
    <dbReference type="OMA" id="GPRWWVC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="456" mass="52120" checksum="6F5CA74E91346835" modified="2016-09-07" version="1">MWIPTMLAPSLYVTLIGLFDAVIMVYFAIATVRQATYIPHSLGPCRIAETWQVPMNGNESYFHVLETLHTYPDDPDMNVPSDKICKDFVSQWRFGIGSLVIYILVSFFNIIVSFALSIVGVRSRMTPERKRKEAFVLSAIKVIFFMAYSFGGTLFLAFWSALDLLPNSVLSRCRFSARYMNKMSQFVAIPIQDRLQKYPISFPFFKRYQPPPAPMMVQAKAKSESAPLARFLHLDILTLVAQHLHYQDLVNLSLSSKEMRETVFPDGHSSGRLGILRIYACDNATKTGCFVCQFPICGSCGDVRRFSRPQLDLLHEETCKPYCSTCFFRKICTRPRFNSRSCDRQITLAGKYHGSRGRFSPDSIENERLVCSSCKPFLIFECLEQRYERGKVKMERKLRHSQYRDDFACKGCSRALSSWGPRWWICDACGSECTDPLHPPWGFKVADTTGHALSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVV3</accession>
    <name>A0A179TVV3_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99934">
        <property type="protein sequence ID" value="OAS99934"/>
        <property type="gene ID" value="BDCG_01616"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01616"/>
    <dbReference type="OMA" id="RGSDWND"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="207" mass="23472" checksum="1B2E5919AE910504" modified="2016-09-07" version="1">MLTATMRQTRTPAAAAGATARRPTPPWEDKSSPRTMPPPRISTLDRRTIPERPERAVPPSPATPATPSSQSGQWSQQDDEILISARAQGYGWTRIQEENFPSKSSNACRKRHERLAAKRKGSEWVEERVQKVTRHYNQLRPEIWRPLAAATGENWEDVEKLCLERGQRNLLPMTTPSSFRRASSDNESRGSHDSHDEEKLRIKSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVV7</accession>
    <name>A0A179TVV7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAIB/BAIF family enzyme, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99562">
        <property type="protein sequence ID" value="OAS99562"/>
        <property type="gene ID" value="BDCG_00743"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00743"/>
    <dbReference type="OMA" id="IIAGPYC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="395" mass="43135" checksum="438A21AA7F8F68B6" modified="2016-09-07" version="1">MSRVLAGPYCTQILGDLGAEIIKIEHPVRGDDTRAWGPPFAKYKDGTKEGPGESAYYLSVNRNKKSLGLSFAHPSGVEILHKLVKECDVLVENYIPGSLKKYKMDYDTVKAINPKLIYASITGYGQTGPYSQRAGYDVMVEAEMGLMHITGSRDGPPVKVGVAVTDLTTGLYTSNAIMAALLGRARTGKGQHIDACLSDCQVATLSNLASSALISGEKDSGRWGTAHPSIVPYRAYKTKDGDILLGGGNDKLFGVLCDRLGQPEWKADERFVRNNLRVKNRDVLDKMIEDRTRQRTTQEWLEILEGSGMPYSAINDIQGTLNHSHVLARDMVVEVDHPTCGPMKLVNTPIKYSDAKPGVRTPPPTLGQHSDEVLRDLVDLGENEIAQLKKDGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVV9</accession>
    <name>A0A179TVV9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_01834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00044">
        <property type="protein sequence ID" value="OAT00044"/>
        <property type="gene ID" value="BDCG_01834"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01834"/>
    <dbReference type="OMA" id="CLAAQMD"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="176"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="363"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="455"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="547"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="639"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="713"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1091"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAT00044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1272" mass="139233" checksum="7DEAA18F8C531253" modified="2016-09-07" version="1">MTRGDETLLAVAGILQGLAKDVPDSASLPFNSYKSNNATNGDVAKINLPGENSDGKAVLERELEDLIRRIGTMQCFVPPSRRSTRAAISSGQDTNSHGSPKPLPGSDVNYEDDIHFLQNRVQLQAQEIQLQKDVISRVREELKEQEKNTEKALGKVKKEDVGILERELRKHQQANEAFQKALREIGGIITQVANGDLSMKVQIHPLEMDPEITTFKRTINTMMDQLQVFGSEVSRVAREVGTEGILGGQAQITGVHGIWKELTENVNIMAKNLTDQVREIATVTTAVAHGDLSQKIESRAKGEILELQQTINTMVDQLRTFATEVTRVARDVGTEGVLGGQAQIEGVQGMWNELTVNVNAMAENLTTQVRDIAMVTTAVAKGDLTQKVQANCKGEILALKTIINSMVDQLKQFAQEVTKIAKEVGTDGVLGGQATVHDVEGTWKDLTENVNGMAMNLTTQVREIADVTTAVAKGDLTKKVTADVKGEILDLKNTINGMVDRLNTFAFEVSKVAREVGTDGTLGGQAKVDNVEGKWKDLTDNVNTMAQNLTSQVRGISEVTQAIAKGELAKKIEVHAQGEILTLKVTINNMVDRLANFAHELKRVARDVGVDGKMGGQANVEGIAGRWKEITEDVNTMAENLTSQVRAFGEITDAATDGDFTKLITVNASGEMDELKRKINKMVSNLRDSIQRNTAAREAAELANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDDLKPYPREMLNVVHSLANSLLTIIDDILDISKIEANRMVIEKIPFSMRGTVFNALKTLAVKANEKFLSLAYQVDSSVPDYVTGDPFRLRQIILNLVGNAIKFTEHGEVKLAISRSDREECKDNEYAFEFSVSDTGIGIEEDKLDLIFDTFQQADGSTTRKFGGTGLGLSISKRLVNLMGGDVWVTSEYGLGSSFHFTCVVELADQSISMISASLMPYKNHRVLFIDKGQTGGHAEEITEMLKQLDLEPIVVKDESQVPPPEIQDPTGKDSGHAYDVIIVDSVDTARNLRTYDEFKYIPIVLLCPVVSVSLKSALDLGITSYMTTPCQPIDLGNGMLPALEGRSTPITTDHTRSFDILLAEDNDVNQRVAVKILEKCNHGVTVVSNGLQAVEAIKKRRYDVILMDVQMPVMGGFEATGKIREYEKKNGLSRTPIIALTAHAMLGDREKCIQAQMDEYLAKPLKQNQMIQTILKCATLGGSLLEKSKEPRMSSSGEPPHHVPNSNGMKSLDTKNQRPGMDSQATSASGGPNPNQKSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVX8</accession>
    <name>A0A179TVX8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Benzoate 4-monooxygenase cytochrome P450, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_01676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99964">
        <property type="protein sequence ID" value="OAS99964"/>
        <property type="gene ID" value="BDCG_01676"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01676"/>
    <dbReference type="OMA" id="MAWHEIR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAS99964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="397" mass="44791" checksum="F46FD848A68D377A" modified="2016-09-07" version="1">MTKPASGIEEQEGAQSVVTAEGDTHSRQKRMLATMFTEKILKEKEALFISHADLLVKRLKGLEGQPVALGDWYNFATFDMMGDLLFGESLGMLSTSEYVPWVKSIHGFLKAFAFTNVLNEYLWFRALWAFVPSKILDTLRDTHFLFTAQKVNRYLELDEKARVGMMGHLLDGGSRKGLNLGELHTNAPILIFGGSETSATQLRALTFLLFKNPEKMGKLITEIRSAYTSSDQITYDSLLERTYLNACIEEGLRYYPPCSNGLPRIVPKSGTTICGEFVPGGTNVSVATFALFRSPKYFSQPDSFIPERWLRESEGGNPVFATDEKGVALPFSYGPHNCPGKKMGYFELRLILAKVLWHFNLKLLPEDDGAEDSWDKMPNYQTWTRRPLKVIAKPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TW76</accession>
    <name>A0A179TW76_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine38-40 synthase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_00159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99318">
        <property type="protein sequence ID" value="OAS99318"/>
        <property type="gene ID" value="BDCG_00159"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00159"/>
    <dbReference type="OMA" id="YQLCDSR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="5">
        <location>
            <begin position="272"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAS99318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="485" mass="54432" checksum="1AE922F6119F30D5" modified="2016-09-07" version="1">MLGYSGSGYKGMQLSPTEKTIEGDLFTAFVAAGAISKANATDPKKSSLVRCARTDKGVHAAGNVVSLKLIVEDSDIVQKINEQLSPQIRVWGIEITNKSFSSYHLCDSRIYEYLIPTHCFLPPHPSTSLGQKLVEIAEQENDLEGYKQRQAEVATYWKEVDEKYIQPILERLPEVTRNRVKRALIVKSDTGPVDSSDSQGEQKLNPSNEGDDAPTSNETSIQTNENKDTSAEDAQTVTTNDAIRMIRAAYLDAKRAYRIPKERMDRINDALGMYVGTRNFHNYTIQKSFRDASAKRLIKSFKISRDPLIINGTEWLSLKVHGQSFMMHQIRKMVAMVALVVRCGCDIQRIPETYEDHKIAIPKAPGLGLLLERPIFDSYNKRTVVEYGKNPIDFSKYEKEIEEFKQREIYERIFREEEESNSFGNFFNHIDTFQDSAFHYVTSGGIPASKSRGGTGKAPMSGKAALKEVESESEDEVVNGGEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWV3</accession>
    <name>A0A179TWV3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SirQ protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_01611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99932">
        <property type="protein sequence ID" value="OAS99932"/>
        <property type="gene ID" value="BDCG_01611"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01611"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="306" mass="34761" checksum="2EBB27F7640FFAD9" modified="2016-09-07" version="1">MSLFTRFIPNAKTIVSVPDSKALDSLRKAVTVIDDLAPKLEFIHLQYGTFIYGTCFAEDFYMPVPLSEGLPPLRKPWADRLPYFNLSRWMDEFSRGKPWKWCETRPDDIIGFLPRPNGYNVAYPIAMFLSLYAYINGKGAQCPFPGSFGVWKALSNDAGADMIAKSAIHLSLSSNLLANGEGFNVASSSTPWSWEMKWPVICTWFGLEGIPPVDRERSETETPGPDEYIRNHEEEYKRMVKEYGLKGWKVASPSMDGSENWGLTKLNFDRQVDLRKTIATGYTDEESNAETWIRALERMRSAKVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWV9</accession>
    <name>A0A179TWV9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase (Ubiquinone) Fe-S protein 7, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_02506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00346">
        <property type="protein sequence ID" value="OAT00346"/>
        <property type="gene ID" value="BDCG_02506"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02506"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="131"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="251" mass="27511" checksum="5ECCA16BFE7730F8" modified="2016-09-07" version="1">MSVYVYYYPPMSAAVLYGRLRADIAKLALSRTKALRDGRRRWDQPPTAAIYGPLFIIIRCNATASSSSTPSRATTGSTLGVARMERSSSLLPSQDEKTGTMGHFLGSIDAVANWGRQASLWPISLGLACCGLEMMAVSMPRYDQDRLGTIFRASPRQSDLLIVAGTVTNKMAPALRLVYDQMPDPKWVISMGSCANGGGYYHYSYSVVRGVDRLLPVDVYLPGCPPTAEALMYAISVVRRKLIVKSRTTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWX9</accession>
    <name>A0A179TWX9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_02430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00325">
        <property type="protein sequence ID" value="OAT00325"/>
        <property type="gene ID" value="BDCG_02430"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02430"/>
    <dbReference type="OMA" id="TWIRLHD"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107122" evidence="3">
        <location>
            <begin position="17"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="212"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="693"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="755"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="791"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="854"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="887"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="953"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1109" mass="123266" checksum="4B97D7A4D005C0BB" modified="2016-09-07" version="1">MEFVGFAAALITLLKATTTAISAVRSYNASEVEASRIDQEIGDLQAVLERLALLEQEADKDEAATGSVLPMLKAPWYNGVFDLCQKELESLNSRLSLQDASKTRRVVQQLRWPLKKKEADQIILNIRKHTESLLQAVQVDQTSMLLKMNNTMQSANKSKLENLQRRINRRLAAVDPSLNYRRARRKRHPNTASWFIESDYFDEWKSRAPSFCWLHGIIGSGKTVMSSAVIEHMAQECLPRPLSALAYFYFDFSDPDKMAPERMMRSLIEQFCYKCRDIPRLERIYDMSCMPNFELEASDLLATLLEIIESFEESFIVIDALDVCSNVPELLRIIRDILRRSSSKVHILSTSRQGKYIEDGVNSLPGNVQKVAMDKTQVNRDICMYVQECLRTDRKFKRWEKYPGILKDIETYTMSKADGMFQWAFCQLEVLGDCFSEEALRAALGSPPKSLNDMYERILRDPFGGRINYIPQVLHWLAFSARPLTIAEMAEMLTIDLNAYLQFDTRRRFFDPREILDICSPLVRVDVEQGRGEVFKLAHLSVREFIVSDNLSTSTEPGSQYHISESSANAEMAEICLAYLLHYFHDTVVEDGMETRFPLARYASRYWVHHVRAAKSITKRIRILAMRLLSSNSLAYRNWIRLYDPEHPTKDPNHTKSRKTIRAPLYYMALIGVADLTEILLAEGINPDAYQGHYGTPLQAACTMGHVEVTRQLLAKGADFNLMKDGSSNALRLATIGGHTETVQLLLEKGADISASGSLLQDAVTRGHADLVKLLLQKGQDPNTHHEIYGTVLQDACTCGHDEVVDLLLENGADINIQSGIYKSPLLAASIKGYLHICTQLLLKGANPDTKGGTYGNALNAAASKGHLRIVETLVQNGATIDAVDWVGDTPLQSSLAAGHESIARLLLSKGANSRWEGGLYGNVLQAASLGGVQCVVKSLIAGGVDVNTPGGRYGTALQAAASRGHVEIIKMLIDNGAFINAEGGYYGSALHAASSKGHENAVWVLLAHGAHVNITVGKFGCPIQEAAVHNHPDVVRLLLDNGADINSSAGRRGPDNILELATRRGSTEVVRVILKWVSDTDVELHALDSSWKAAVECNEHEIAALLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWY2</accession>
    <name>A0A179TWY2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 2, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99962">
        <property type="protein sequence ID" value="OAS99962"/>
        <property type="gene ID" value="BDCG_01666"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01666"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PTHR13303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="104" mass="11798" checksum="4FB2363496522938" modified="2016-09-07" version="1">MFHAPKPPSPSPAQITYLLTYPYLSASPPRLVIDTLEPLAGDRKCFRLINGVLVERTVKDVIPPLKTNSDGLKQVLDELLKQYKAKQDELDGWKKKNNIQVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWY3</accession>
    <name>A0A179TWY3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00424">
        <property type="protein sequence ID" value="OAT00424"/>
        <property type="gene ID" value="BDCG_02772"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02772"/>
    <dbReference type="OMA" id="ENRYCAL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="327" mass="36224" checksum="99B835C49F08DCDC" modified="2016-09-07" version="1">MTATVDSSSTPQSFTGVPNSEIRYSGFSSRQEQYTTEHMNSRFSLYKSSTFHYNMPSHSSAFAQPSYHYAGPGHTHLPAYGIEPESASSLEFPTNFTHRNPPPQASIPSDGLINMPPPGGYHYSVPQSQVSSTRQYKDRISITLSEHHAPDQESRPSNSRDEYIQHGFTSHPATEPYSDLSTNMASLTPDYLNHPVPNVTGHAYPASPSLYEPLHPYQRQYSFSPIPDTGVPATSASADNFSTPYSVSPAPEDQVRIVNSRPKPQCWDHGCNGREFSTFSNLLRHQREKAGTATKSECPHCGTVFTRTTARNGHLAQGKCKAKREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWY4</accession>
    <name>A0A179TWY4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99537">
        <property type="protein sequence ID" value="OAS99537"/>
        <property type="gene ID" value="BDCG_00706"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00706"/>
    <dbReference type="OMA" id="SKQRQGH"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="518" mass="59031" checksum="7E830F1B3905D80F" modified="2016-09-07" version="1">MIILIRHAQSEGNKNREIHQSVPDHRVKLTPEGQKQALEAGRRLRALLRPDDTLHFFTSPYRRTRETTEGILTSLTSDDPSPSPFPRNTIKVYEEPRLREQDFGNFQPCSAEMERMWQERADYGHFFYRIPNGESAADAYDRVSGFNESLWRLFGEQDFASVCVLVTHGLMTRIFLMKWYHFSVEYFEDLRNVNHCEFVIMKKSDDDGKYVLQNNLRTWSELKRERERERERERALKGDSGALISPDLEMESHVPIRRKWGGCPNGCNHSAVKFWKRRPQRQYTKEILEGDTATYGGSNDTQFVASQANPGYSWDIPVDNPSSTHYHHAPPSTSSSSPNSTPSHISLNLHVDFKSQLELSSEQELNRSQNQSSTSFHNRKGPHNHPTRLGGRDGGGSESGATSRATSDNEEVDNVGYNNENYKHVAASMQSGRQSHGQRQLQSNDRRQGHGIANSLGDRDDDDRSAGKQGLLDDDDKDGNDRDIPKAGPYSSDELEEEEDAVLEKAIREDRSIRGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX67</accession>
    <name>A0A179TX67_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00405">
        <property type="protein sequence ID" value="OAT00405"/>
        <property type="gene ID" value="BDCG_02684"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02684"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="SSF69848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
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        <location>
            <begin position="425"/>
            <end position="467"/>
        </location>
    </feature>
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        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
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        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
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        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1035" mass="111057" checksum="ED962B61C246EE30" modified="2016-09-07" version="1">MADLLPCSPTAHQPHQPPPPPPTMSSRDMSHPTQPYEHARRRSLGSNGSSPVYPASGQVDQQGGQQPPPPSSSYTSRQMPPPSSPQHYHARGAPIPGLPPPAPSSFPPREPPQPSAHRPGSSMSISSMLGSDSDRPPRDSGPSSIYGRPSVSSVPAGSQQGAMSPPSAPSRQPQPSSDFPPLRRSHTPDRGLFSNPQPPRPYRSSSGSAPQNQPQPPPPEDTSRFGALSRPQSLSSIYGDKPQASQPTPSGLYAVSPYNQDRRGSISGPIPRPSSQPHQEEPPSSRRSLFSPGTRSSGPHFGDGSSKESGLQPAAPGYPGPEAASHAQRRYGIQHQERHCPAEPVSREQEHNGRLSQEMKQQQPRFGSHFGEREPEGAPRPTWDSSGIQRLSPEAARHSISNDFGGMRNTKPLGSQLPGPRSVPGPHLQQQQQRPEPSQRNDSQQSSSLNKFQQPSRIFSPTLGPGSGSQRPLGGMGEDQKRKDSDEPFQHRSLLNLNAENKREGRSSPLPQAVQGAQAQIIGPAEEAGIKSELGRVFSGIGSGVGVSAASHPGSGPSTPMTSSPFKRDGIAARSAGAEINESATKPARTSVPGPARRGRKPKDDDMKGEGEGSAGNRGAGTTRGRRPRHVHHHHHHGHHHHHRHKLDDEASGSLALQNAIPPPGVAGFQRSPIHPEGTALSPSTVAPHHHHHHHHHVPRSTTGGTSVVPPSTSTSAAPIREYSTIVNLQPLLRSVAHRPRYHLGSTLYAPKIGVPPSRASPESSKFGYVSTPVPIPRFEGKENCTYTIRVPRFRIDASHREEICARRALWGTGVYTDDSDPVAAAIHSGFIRGEWGEDVDVSLLDLEIKKEHQHAPNGKNGTTTALPKLSSLDELGVKEPKPSDKPETTTTTTTTTNPTTKSKSKPKIPPLPPPNKDLHITLLILPTLERYDSTVMFGLKSRPWGDNHDGMSFKVERIDWVDEGGSKGEERGGEARRKRLRSMMLSGRICTPGGMKGRGGVELRNGSKIGGMGMRMSMGMDGGEGGIKAVEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX70</accession>
    <name>A0A179TX70_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_16238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99637">
        <property type="protein sequence ID" value="OAS99637"/>
        <property type="gene ID" value="BDCG_16238"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16238"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="126" mass="14244" checksum="18569CF42282EFF2" modified="2016-09-07" version="1">MPMITSDATQHSPVQTRRYVFPRADILEIFQEFLIFKTRTFLGYVLFVQAFLLQVLSTLSTESVVLSNARLLTAVPVAESGNMRRMNMVSSVLCFPGCFGLNLLGIYSLKSGSHQWYIVREALLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX72</accession>
    <name>A0A179TX72_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydrofolate synthetase Fol3, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_00419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99436">
        <property type="protein sequence ID" value="OAS99436"/>
        <property type="gene ID" value="BDCG_00419"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00419"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAS99436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="326" mass="35137" checksum="6F376A08421118F1" modified="2016-09-07" version="1">MGGRLDATNVLNDSNVLVSIIAKIGYDHQAILGDTIEKITREKAGIMKPGVPCVVDGTNDPAVRSVLEEVARETQTPLAFTQPEAVTQEFPELGKIFERLNVELHQQANIACAVTALGQKNFLPPSLPLPSLFQHIPKTPRAGRLHEVSLKPLIARKQPVLLDGAHNPQSAHVLCSYVDRNLRKQPCTRGDAHGSNHNVTWVIAASQGKDTQELFSCMLKPGDNVAVVEFGPVDGMPWVRSVESAELLSVVRSGRESMPNIARSEGFGGNIVSALTWADEISKSSGCGRSGESGPMVVAGSLYLVSDVLRLLREANNNNIDVLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX85</accession>
    <name>A0A179TX85_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING finger domain-containing protein, variant 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_02875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00466">
        <property type="protein sequence ID" value="OAT00466"/>
        <property type="gene ID" value="BDCG_02875"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02875"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="385"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="498" mass="54768" checksum="ED5A16A6B095A85C" modified="2016-09-07" version="1">MAANAFDAVVHAIPSEGSSLTRPVPVDSSISFELSIGDKIQTLSTTNVRNGDAIRGLLYVPELDFEDPCRQATTPFILANVTRLSDIPGPRRSISLAPWVSSACTISFLAALSRNPPYAAVFYRPDESTTTPPLADHPTWDLGDRDMWKTTNRYPVYAIPGVYGASVMRALSEYSGSVADAPYAEDLLRRFQGSDVVRVSSKIAISKNSTGGLPSLWIFLLVVVAILICIALFSSIAMRCIQARQLRSLERRVAAGEVDLETLGIKRLNVPQDILDKMPLYICNGSGRIERLIPPTTEMTPESIDEPSKLPPDKGSFLQSISGWKWISRVSQAFYSRKSRSTTPPPPLSSAPDSGTSLPSPRSQTTPIDNNQQHHAEPTFAQTTCPICLDDYDWGETTVRELPCQHIFHPECIDNFLLQNSSLCPVCKKSVLPRGYCPEKITRVMVRQERLARRARPPQTIEIGNGGYDAAMPTSLGNGNQSPQNRNRPPGHSFTSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXW2</accession>
    <name>A0A179TXW2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_02626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00390">
        <property type="protein sequence ID" value="OAT00390"/>
        <property type="gene ID" value="BDCG_02626"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02626"/>
    <dbReference type="OMA" id="RARYTSW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107132" evidence="2">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="214" mass="23524" checksum="F69EA1E0EEE7B559" modified="2016-09-07" version="1">MRFLMVLLYVVNTLGRICCTWLGCHRRKKRRYRPRSEDESHELQGQGVHLSGQDRSRQGYHFREANQPRRQLSEVERAQVAMALGNPRYPLPRQAAPAPAPAPAPAPVHAPTPVPTPAPSPAPAPVEAAKGSSESIRVRDIPPAVDGHQSDQNTDAATRESDATQQQTNEPRNIQPINTPVAKPSAQMTEDEIKDRVISECNPVESEDSPSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXX7</accession>
    <name>A0A179TXX7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide synthase Cps1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00774">
        <property type="protein sequence ID" value="OAT00774"/>
        <property type="gene ID" value="BDCG_03542"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03542"/>
    <dbReference type="OMA" id="HEKHIWY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048856">
        <property type="term" value="P:anatomical structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="352" mass="41493" checksum="05C34BB70A42FF83" modified="2016-09-07" version="1">MLEKMPASKARIKLLSIPKPNKRRQMVRAIPEVQTKITVFVDDDVSWPPKELQWLLAVFEKDPIYGGVATCQRLRRSDSPLFSTQRVWDFLGALYLERRNFDCAATTHVDGGMPCLSGRTSAYRTKILQDRDFTYNFTNEEWWFGKYELNADDDNFLSRWMVTHGWETYFQYHPEAEIQTTLENNANFLKQCVRWSRSNWRSNLTTMIQEQVVWYRQPWSTYAVYLTTLSPPAFIGDLALVVFCYYGTKEWSEESRMFALQSLVAWMFVSKFIKLLGHYIRYPVDFLLLPMSILFGYFHGLIKLYAAFTLNVTTWGTRDGADASDAERMRKKPDDEEHTREKYYSLFRATKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXY4</accession>
    <name>A0A179TXY4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99897">
        <property type="protein sequence ID" value="OAS99897"/>
        <property type="gene ID" value="BDCG_01515"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01515"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107134" evidence="1">
        <location>
            <begin position="19"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="427" mass="46881" checksum="8301F1E681A2F957" modified="2016-09-07" version="1">MCFIFSVCTLSRLDICYCWTAAPSTPNIIETPSKSNLVTVTVQPYIKSSEDGHPEESSVIIASGADKRVSLYEVDAPYSVISTFKDLVDSPLLSGTCLYDGAYRATTTMSGQLLLFQGQKIIASRKDHTKCAVAVVAFQEEQPIFQTTWLATAGWDSRIYIYRITIPDVGAQLTIGEPLAVIKTATVPECILFMRSQGTGDLVLLASVADSTNLYYYLVESPLNRLERGHRTINNQPHECPLLGKQDLSPHSNAWVAFSPACFALSPRDPTLLAVATSSQPYMKLIFVRILMPSASPSTPPERRQSSGQRVTQALRAMADLGIHNREDAAILAQVNTMAPQTAYSTPQVVWRPDGSGVWVNGEDGVIRGIDARTGKLVVSLTGGHEPDTKVRSIWAGWVRLNDGENEERLVSGGFDKKLIMWTPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXZ6</accession>
    <name>A0A179TXZ6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS multidrug transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_02444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00333">
        <property type="protein sequence ID" value="OAT00333"/>
        <property type="gene ID" value="BDCG_02444"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02444"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="118"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="475" mass="53150" checksum="486E7AA0393714D8" modified="2016-09-07" version="1">MTASDPVAQISAQEEHKRSHSRHKTYPRFVPKFQASLRDKLPSSAESDALRLSSFTSHPTSGEDHYPLRNGQRELLPIAPISPIGSAQKDETTKTLLLESECYGILGFSFPRWKKWTILSVVFFVQLSMNFNTSIYANAITPLAQHFSISEQAARVGQMIFLVAYAFGSELWAPWSEELGRYPIMQLSLSLVNIWQIPCALARNYHTIVVGRFFGGLSSAGGSVTLGMIADMWEPDDQQFAVAFIVLSSVAGSVIAPIVGGFMEVYLDWRWNFWVQLIFGAAAQLAHLLLVPETRTTILLDREAKRRRKAGQPGIYGPSEIHGQGISVKAVAIIWLRPFSMFVREPIVFCLSLLSGFSDALIFTFLESYQPVYAQWGFGTIHVGLAFIPILIGYFIGYISFLPIMTKHRKIHRKNSNVLEPESRLWWLLFTAPLETIGLFGFAWTSLGPPQVHWIAPMIFSLLIAVANVNGDSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXZ7</accession>
    <name>A0A179TXZ7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Autophagy-like protein 12, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00695">
        <property type="protein sequence ID" value="OAT00695"/>
        <property type="gene ID" value="BDCG_03398"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03398"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="185" mass="20380" checksum="77088C1F780F0C12" modified="2016-09-07" version="1">MGWCMEKVCRTQRTNIKYLFKYLNQKPFPSHPTPTPLIYPHIPHSRHSNGINNCGLTIQTSSRYNINKSTMASTPPLSPSPDPSKPASPRVANRGLGLASRQGSRSSRNNNDNGSKGAATTPIPDEDYSADLPLTMSASIVLTGLPKDSHQALADVDAIDSGKGTHYYLEYETFSLSFWRPEMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYX1</accession>
    <name>A0A179TYX1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Linoleate 8R-lipoxygenase</fullName>
            <ecNumber evidence="4">1.13.11.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_04255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate</text>
            <dbReference type="Rhea" id="RHEA:25395"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:58659"/>
            <dbReference type="EC" id="1.13.11.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.60" evidence="4"/>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01086">
        <property type="protein sequence ID" value="OAT01086"/>
        <property type="gene ID" value="BDCG_04255"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04255"/>
    <dbReference type="OMA" id="ICPTYSV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052878">
        <property type="term" value="F:linoleate 8R-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT01086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1034" mass="116230" checksum="E3C5D745ED882FAD" modified="2016-09-07" version="1">MKHPPKNMDLKRVGDVVKFVKDTVKGKPMNDRLLAMENIIAIVGALPPNSKHRIKLTNILITRLWDSLEHPPINFQGPKFYYRTPDGSYNNVHFPNLGKAGMPYARSIRSDTKLPGVRPDPGLLFDLLMKREDGKFKQNEGGISSLLFHHAALIIHDIFRTDRRDMNINNNSSYLDLSPLYGSSLKDQLKVRTMKNGFLKPDTFHDERLIAQSPGANVLLVLYSRFHNYVAETLLLINEGGRFTPKGDDEASLAQLDEDLFQTARLIVGGLYINISLHDYLRAITNTHHSDSSWTLDPRVDIPASLVKSGPERGIGNQVTTEFNLLYRFHSCISLGDEKWLDEFFGEIFKSTGKPLEELTLKDGMRAIAQFESLIPMDPSQRNFGGIERGEDGRFRDEDLVRLLKASIDDPAGAFGPKNTPKAMRVVEILGIHQARQWRTASLNEFRKFFKLKPHETFEDINPDPEIADHLRNLYGHPDMVEAYPGLYVEDAKPRMDPGSGVCTPYTVGRAVLSDAITLVRSDRFNTTEYNVATLTNWGMAEAQQDYDTLGGSMFYKLIQRGLPGWFPFNSLSVMQPMYTPAMNREIATELGTISQYTEADPKPPPRRLVLMKHSEISQMLSDPKQFPVPFGKPYENFIEGRDFGHFMLAGDMPRNKEQRNLYGSALYGSGELKELLSTFIVDQTDKFLTGSMFQIGRGTYHVDILKDVAIPVMTRFMGDLFQFDLKTEENSSGTYDIDGLYNDLLNIRIWGFGNDDPALSWNRRRDAQASARRLLASTEAYIKRVTSSTRIRNIVGAVTNGLASNGNSTSLRSFGRDCIMELLSNGKSVQEIADIMVFTALGGIGAAISTLAEVLEFMIAVPENVEHLEAFQQLTLENSERADNDLRRYVLEMQRLTAGHVTIRVATQPGGFGAQSFQPGEQIIAYFAAACRDPEAYPEPEKIKLDRPLEKYIAFGDGPHQCFGRELALAFLVGVLKRVTALKNIRPALGGMGVLKKIKRSGIPYYLSEDWSSFTGYASTWQLQFDDPDFVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYZ3</accession>
    <name>A0A179TYZ3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMGC/SRPK protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00673">
        <property type="protein sequence ID" value="OAT00673"/>
        <property type="gene ID" value="BDCG_03328"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03328"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="112"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="463" mass="53290" checksum="40A07EFFF0BB71ED" modified="2016-09-07" version="1">MHKTWSPQLARPSLLRLSRKTQTRSVVNFLKTVTDVNVAGYKPWTLTYIMLLRLKAPMMFTRRIFQSTPFAAPASVAASLTATGPIEEERAPRYNPSHFYPVRLYQVLNDRYQVVAKLGWGTSSTVWLAQDLHQWRWLPRRYVTIKVSANNYADKKSAETELRITEHITKANPQHVGYDFVRTLLDSFELRGPCGTHVCLVFYTLREPLWIFKQRFQNDVLPSDVLKLIATMVLQGLEYLHSECHVIHTDLKSDNILVGLRDESILEIVAREEFEHPLPQKILEDRIIYLSRNGLGLQTKGIGRPVITDFGLAVRGDVSHPYYHTIQPDDYRAPEIILTAGWSYSADIWNVGVLLWDLLEKDGIFEALNPHKMEYTSERHLAHMIALLGPPPKELLDQGSESTKYFDHSELIPEGLSLVDSLNQVEGEDKISFLDFIMRMLRWQPEERSSAKDLLADPWLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYZ7</accession>
    <name>A0A179TYZ7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MADS-box transcription factor, other eukaryote, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_02301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00258">
        <property type="protein sequence ID" value="OAT00258"/>
        <property type="gene ID" value="BDCG_02301"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02301"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="MADS_SRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SSF55455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT00258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="215" mass="23198" checksum="955EEF2392E6D356" modified="2016-09-07" version="1">MADITAVSDENPSPPQDDLVSGGNGAAAAAAAAVAAAVENRGTKRPRTSNAGDEDDDDEDKPGRERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKPEGKNLIQACLNAPEPTTNENGVEVPEVPPETSDDVSHANVAGQQPNIPRPGGMHPGYMSSEHQQQIAYYQNLQQQQQQAQAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYZ8</accession>
    <name>A0A179TYZ8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">F-box domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ER-3</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00076">
        <property type="protein sequence ID" value="OAT00076"/>
        <property type="gene ID" value="BDCG_01868"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00077">
        <property type="protein sequence ID" value="OAT00077"/>
        <property type="gene ID" value="BDCG_01868"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01868"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="64"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="504" mass="57806" checksum="08DAC2680BD6D7B8" modified="2016-09-07" version="1">MIEENKTDSRGYLRTAKILQLMDKHERALQTYHYALRILPSDDAGRQQIKKLAAKLEKRFKQPIDYFALLPFELMSMILEYLDLKSLLSALRVSKHWNMVLNSLPKLWTHLDLSKANRPISLKSIQVFLRRSHWRLTRASIANLQSVDFPKLMAGLQKIPSLEHLELLPGFYPKFEFAPVYTLTSLRTLVCSATSEMTFSDFMKVLSDCPLLERVEVHIKPAPPSDYEVFPAKLPNLRSLIVLGCRHYRHPHDVSPLDLPFLRNATLFDITPNLEELYLIHRSCSTTLRMSDVPKISNLPKLKRLGLLGIKFNNYPKLPESIEHLSLSMSEYDPPIILPSNTISAMTPNLKSLILQRFQYDELGTFLIALTQSKPSLTNLDLEGCHLHVEDLLIAMMQGNLENLMSLNISGLAEIDDKIITNIIDMVPNIKELDISRTQVKEHSVKRLLDCDKLKLEKLVIHKMETPFSRDFIDYARSKGVEIPPPINLEGRKRVPIPPASPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0C8</accession>
    <name>A0A179U0C8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_02457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00341">
        <property type="protein sequence ID" value="OAT00341"/>
        <property type="gene ID" value="BDCG_02457"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02457"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="269" mass="31032" checksum="8EBC3961A1BE1E58" modified="2016-09-07" version="1">MADGIGREVHYKFPNDEREQDRLNLIHYAIYYLCDERFFLAPINPDGKRILDIGTGTGKWPIEMGDLYPSAELTGVDLSPIQPRWAPPNVKFIVEDLEQDWVETELYDFIHCRYMMGSIKDWPRLVKKFYEHLKPGGWVEFKDSTATVFSEDGTVTPDYKVVEMLRNLRLASEKIGINMDHAPLLKGWMEQAGFTNIEQRVMRLPIGTWPKNRRLKLIGAMMASHYLEVEAFTLIPFIEILGWSPAEVEELNAQVRAAVQTKGVHPLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0E9</accession>
    <name>A0A179U0E9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_05541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01565">
        <property type="protein sequence ID" value="OAT01565"/>
        <property type="gene ID" value="BDCG_05541"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05541"/>
    <dbReference type="OMA" id="DINTMYG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="PTHR22792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="684"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="879" mass="94544" checksum="D80924AEC5B1472E" modified="2016-09-07" version="1">MSTSTSRPGLEMPAFSYAQAAKGFSTPPSVQIVAEKQNKSSTTSSDPSSHRTATGSVDGDGSNRTVASSTDLESSSVATEPADATDKSQSSSERSSDWTVTPPAAGAPWKTATSGTSSPSVGTTSTTTLPKEDDTSGTPNGIPDSSWDKQSQVSGTVEKSSESGESGKEKLKENGWEKDVPVLKELKAAPIPAVNVWQQRREAQEAKAKASAALKSTTTAAAKPFNSKSSVPSENRAEGSKGGPRKKAGGSEVAADAAIAKKKSSESGKSKEEAETLPPVGDASSWPTPQLAQGEEFRKAQEKSDKTEKSEKEKAPTAGSRGKEKWMPVPYVPTAVFNTPLPPAARRGGRPSRGGREGGMRSGAHPSAAISSSDRSVPASASAAGGSKQTGSSDRGRSGTRVDSDQSGTTQPARTGSVNAPLSPDEKKAPHDSRPDRASSDSKSVKAPEEPRGTTGGETQTNHPAAETGPRQRQNSKSFGRSHDYSNVTSQRGTEHTGRHAGVQGDSHAGTRFSSGHERRFDNGPRSAEFYKEPPFHPRDRELSNQREREYPRERNDFHRDREYGRERGESRPERGRGGYRGRGGHSNYSGAHNSQYHSPPVGQSQFQSTKPFSLSERHRSHHQASQNGGQQHGSNRGLNMRSPSLPSSGVYGPTPYPIQTDLNAMYGYPVLHQGPMTAIPYHPYMEHSLMSMISMQLEYYFSVDNLCKDLFLRKHMDSQGFVLLSFIAGFKRIKSLTEDMDFLRLVCRQLKSVEYRPGEDGNDRLRKREKWEQWILAMENRDPSAQNEGPPPLSLSTPAHDGNSDGLNSSHLETTALYGNGSLHEISGNAIPSHYSLSNGATSDTRVHQSVLSSAAPEFSPAYVPVTGQNENANRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0F5</accession>
    <name>A0A179U0F5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99871">
        <property type="protein sequence ID" value="OAS99871"/>
        <property type="gene ID" value="BDCG_01459"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01459"/>
    <dbReference type="eggNOG" id="ENOG502RPK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="641" mass="73053" checksum="472430273BD903F5" modified="2016-09-07" version="1">MSSIFNGMEVPFQNPPPGLSRPFLRDMYLLVEPLAPLPDPPSRSTIQYSIKERSKLPPYEPPPGDEDFALVFSTGDTPPPSEAGPEEDFENAYFTRLEQKIKDFGRYFNSKAWMVHVPAMAEKLVKDATPGTFKHFLLLLLEPDETFAKAQHSVQTWLDERYSGRGVDNIPERGPYALWVAEKQLLLGEIELLRKLVEPLRDGGKTIYWLEKNHCRHLYTMRSLKKAYKIIIEFENETTTRTILNEEEDFSLSTLSGDFRLAVMSMRMARIDVCKESLLKLPPPTVPKFNDPTTSPASERRLHKCKNHQPRPDGTEHLDRPESSLSPQPHEDLLKYRLEAANCAGTMDDVIETMMNTARWLAKARCTESVDLFCDVARMFSPHDPPANLSNEKYSLLRVLCDAMFDTDDVGSEAPYVTDRYSEDDLDVTTNREYFVDAAASRRSLMRDLQLRMAAERPIAPTQMHGHRFSSHGSIRRGRRRARMLNKRARSEIALPRSIAHRYKFTLPADPSNWAANYTSPFGEAFQAELDRQEESRAYQCLKMICEEGLKARSRAVPSQTAPVQRAKESETDVKQKRRGLSARCSGNQASAMIIEALMKNGHGDAVSDAQEKENLIVPGRRTLRAKEQVDKSQRHVWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0G2</accession>
    <name>A0A179U0G2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_03527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00759">
        <property type="protein sequence ID" value="OAT00759"/>
        <property type="gene ID" value="BDCG_03527"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03527"/>
    <dbReference type="OMA" id="ESCTELM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="623" mass="68856" checksum="5BD381D8BFF3F223" modified="2016-09-07" version="1">MTDNGSPAASDEQQMSKYYETQVQKLVTEPHAPLAGFLEGLAEKHHSRISELESMPSRAHDSIWYPFTQHQSIAPRDIMVIDSAYGDCFQTSKGSSTESGSKSTTSNTAPAPQDTLNLLRPTFDGSASWWTQCLGHGNPELALEAAYAAGRYGHVIFPGAIHEPALSLAESLIKKMDNPRLKRAFFSDNGSTGMEVAVKMALRVACKRYNWNSTKEDIEILGLRGSYHGDTIGTMDLSEPSIYNKKVEWYRGRGHWFDFPTVKMIRGKWIVETPEDLKGSLGENTEFPTLQSIFDLSRRKQSAAGRRYKTYIKKSLENLVLQDGRKFGALIMEPVILGAGGMLFADPLFQQAVVEVIRDNPDLFGQGYNNNAPPPPQPPQPPQPSLASDHAWSGLPVIFDEVFTGLYRLGRASSASFLDTHPDISVHAKLLTGGLLPLCITLASQEIFDVFSSPHKVDALLHGHSYTAHPVGCKVADASLRMLTAKNAERYQQAQQHDHNNRKHDQPSVEIEDVKMELNPLAQPRHAWSRWSEQLVRDLSHSEQVEAVFALGTVISISLRSQDGGGYGSNSAAGLQRQLAKTNADGFNIHCRVLGNVLYLMCDLTSDPDELTMLEKSVRTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0H4</accession>
    <name>A0A179U0H4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_03195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00617">
        <property type="protein sequence ID" value="OAT00617"/>
        <property type="gene ID" value="BDCG_03195"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03195"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="292" mass="32600" checksum="2AC0D40E31CB18A1" modified="2016-09-07" version="1">MQWLFGVLRAEIQQYYKFQFQTHLVDGTFRLCHSSCDLLDVGTLDDYFVNVTEWLRENPYDVLTILLGNGDFAAATEFIAPLKKSGLLDYVYTPPKIPMALDDWPTLSHFILTGKRVVVFLNYEANQTEVPYILDQFSQMWETPFSPTDISFPCDIQRPPGLSEAAAKDRLYLASHNLNTMLSFAGQSLLVPNTVLLNETNAVEGFGSVGKAGIDCADKWGRPPNFILVDHYNMGPVNGSVFQAAAILNNVTYNGKCCGRLKSASPSKLFSQLSNQVWPVYLVVAMMVTAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0J4</accession>
    <name>A0A179U0J4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial dicarboxylate carrier, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_02717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00411">
        <property type="protein sequence ID" value="OAT00411"/>
        <property type="gene ID" value="BDCG_02717"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02717"/>
    <dbReference type="OMA" id="FGAYEVG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="153"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT00411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="253" mass="27773" checksum="87A8CBEDE9C72294" modified="2016-09-07" version="1">MLRTAAHIVKNNGVLGLYNGLSASLLRAITYSTTRFGVYEELKSHFTSAESSPSLLTLVLMASAAGLAGGLVGNPADVLNVRMQSDAALPPAQRRNYRHALHGLMQMVRSEGPSSLFRGLWPNSARAILMNASQLSTYDTFKGICIKHFGMSDNINTHFTASLMAGFMATTICSPVDVIKTRIMTANPAESKGHGIVGLLKEVIRKEGFSWMFRGWTPSFIRLAPQTIATFLFLEEHKKIYRALNPRIEDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1E5</accession>
    <name>A0A179U1E5_AJEDR</name>
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        <submittedName>
            <fullName evidence="9">Purine permease, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_06372</name>
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    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01935">
        <property type="protein sequence ID" value="OAT01935"/>
        <property type="gene ID" value="BDCG_06372"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06372"/>
    <dbReference type="OMA" id="RKSAPFF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
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            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT01935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="510" mass="53996" checksum="A9511AA12ACE03BD" modified="2016-09-07" version="1">MSGSGGAELPDSTAQYLVSTSLIVSGSLSTIQMARFHIYKTPYYLGTGLISVVGTSFATIPVAMGAFAQMYESGYCPVDEQGNHLPCPQGYGALLATSCLCALLEIGLSFTSARYLKRLFPPLVTGPTVLLIGIKLIESGLQNWAGGSGSCVSRPTEGPLMLCPSNDAPHALPWGSAEFIGLGFLVFLTIILCERFGSPIMKSCAVVMGLFVGCIVAAATGYFDRSAIDSAPSASFIWVRTFRLELYPPIILPLMAVYIVLMMEAIGDITATCDVSRLDVEGPIFDTRIQGGVLADGLNGLIAGLCTITPMSVFAQNNGVISLTRCANRKAGYCCCFFLVIMGIFSKFAAALVAIPSAVLGGMTTFLFASVAVSGMRIISTVKFTRRNRFILAAALALGMGATLVPNWFSFVFTYNGDNKEKQGLLDAVELVMTTGFAIAGFIALILNLVLKEEEDEVDGEAIKMTSEPGSGSGEGVEEEEGVRGKGVESSDHPSHRLNDVENAAVIKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1E7</accession>
    <name>A0A179U1E7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMGC/SRPK protein kinase, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01914">
        <property type="protein sequence ID" value="OAT01914"/>
        <property type="gene ID" value="BDCG_06342"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06342"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="351" mass="40420" checksum="EAC64180E98CF0EE" modified="2016-09-07" version="1">MTSLLRWAKATFRRVPSPPVCFPTSGYVTVSGSELDEERFEEFKKGRYYPINIGDVLTSRYQIIGKLGFGVTSTVWLARDLEGHKYVTVKVYTRDEVNQEEFQIYKYLKQGNPSHPGYVHVRKALDVFTIPRPGGGHHCLVQKPMWESFKDLLYRNPNHRFTEDLLRVGLMQVFLALDYLHTECKLVHTDIKGDNILQEIEDRAILERFAKAEMENPSPRKFINGIPVYASRRFELPKTFGKVVLSDFGSAVRGDERRNHDAQPNVYRSPEVMLKAEWSYPIDIWNVGVMENQVWDLIEGKHMFHGNDPDGKGYSTRAHLAEVIGILGPPPLDMLKRGKRSLEFFTEDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1H2</accession>
    <name>A0A179U1H2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase, variant 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_04474</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002628543.1"/>
    <dbReference type="EnsemblFungi" id="OAT01168">
        <property type="protein sequence ID" value="OAT01168"/>
        <property type="gene ID" value="BDCG_04474"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01169">
        <property type="protein sequence ID" value="OAT01169"/>
        <property type="gene ID" value="BDCG_04474"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01170">
        <property type="protein sequence ID" value="OAT01170"/>
        <property type="gene ID" value="BDCG_04474"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04474"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT01170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="233" mass="26955" checksum="BB4451838F8FBBFC" modified="2016-09-07" version="1">MFVFKYYTDHLLNLTQKDLPLKVKKKILKCALHGVAELHDHDIVHTDIKPDNVFIDWKDDRDGIIIDQVKLGDLEDAAHIPPGSHMIEKQVGNWMWRSPEAHAKGPVNKPSDIFSFALVCIYAMHKRVIFAVGEEELDEGVDPLAIVIERQISYFADEDTLNGFLKYLGNNPWVRVFEVIRDGFNKDNPRRPFFLWKGVDNDFKSFIRATTNFDPEKRITAHEALAHKWFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1I9</accession>
    <name>A0A179U1I9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIMA-interacting protein TinC, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_03556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00781">
        <property type="protein sequence ID" value="OAT00781"/>
        <property type="gene ID" value="BDCG_03556"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03556"/>
    <dbReference type="OMA" id="DIFPHVG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107164" evidence="2">
        <location>
            <begin position="26"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="848" mass="94958" checksum="E71C6A2AE51FC316" modified="2016-09-07" version="1">MAWSTTTTVAVTCLLFLLFTRPTHAFGAGNIASISKIEGQNWRHGDIEDVILTLLMARSAGGKKFSKMHLKRIYFGNWLRDYSQAIDIGTVKYVSAEAIRLLLWVLGFMSFGYGTGEFEVTIDRLGCYQPTEHIDNPLGYGEGQDPRRYYSRLRGPVDEQRELGIDPRTGMKNYIATEDLGIDNSATLLRRIFGECIALGRRYSRSGREADLFEALRLLGTGLHTLEDYLAHSNYTELSLIELGETNIFPHVGRNTMIELRGARNPVYPIVTGTFGGVDFLHSVMGEISDKATQSEIQNLEGLIKESENQKPQEGFLQALLDKIPDSLFGGDDSTGKMNEFQSNAESTKQRNENITPRESEAWATYMNDVHQQMYPLLEWHDNLMKSINEAIDKIPVLPELIEQAQEQITVFVFSVMAPYVLPIIRQVKQELETGSSEVIQNSKQEQFNTFTDDYCTDPTHSMLSKDHFSNVLNEPAGKAASEIVRWVVPQIMECWDDESVDVDRVMNRIISGVLHHPALREYGEDGAQEMRGIMFGVVESWWNEQGRRGQDSLRQQLRREGVQNGENHKPGVHDSGHGCGKPMGLPNRDRPVAGGALDLFGLEGLRAKTSKSSASDIEKMASKAIGGGLLGSLVGGIVGSAAGGEFEERDDEHKKHNDGDDYEREGGGERYERDRYQSGGYRQPQHGETAGYGRAEEGASSGGYEAGGHGGYSGSESRGHGHSESQRYGGGDRGGEARGYSGGYGSESRGGYGHQQEYGTSSHKHHGHRERSKSRERSSRRYESGHYGNDERRHGSRERSRDRRRHDDDSGDDDYRRRHKKKDDDGDDGSDDGKKHRRKHRHHRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1J5</accession>
    <name>A0A179U1J5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 6, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01179">
        <property type="protein sequence ID" value="OAT01179"/>
        <property type="gene ID" value="BDCG_04505"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04505"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="636" mass="68228" checksum="45A63BD76CE70387" modified="2016-09-07" version="1">MCYLRGLCYARQNAFDRARDCYKDAVRIDVQCFEAFDQLMKNSLMSPAEELEFLESLDFDSITYCTDPSIAQEAAEFMKLLYTTRLSKYSSPYALSYATETLSTHYNLADNPDLLLSRAETLYTQCRFPEALSLTSSILSSSDDSGPMLASQGSQGHNLGHSPAVYPLHLACLYETGATNALFLLAHTLADNVPGESYTYLAIGVYYMSVCKISEARRFFSKASLLDPHSAPAWIGFAHTFAAEGEHDQAIAAYSTAARLFQGSHLPQLFLGMQHLALNNMSLAHEYLSAAYSMSSGSMSDTIPSSTESLSQSPAPSGGDPLVLNELGVVLYHENNLEGAVELFRQALALASSLNCDPGAWLATRANLGHALRRLGHFEEALAEFDESLRIGAGGSATGYGAALAGAGAGGLVSAGSTSVGGYEDRGLTGSLHTARGLVLLELGRTMQAVTALHEAVRVLGASGSDAAAGAGVAGTLLSRALEIWEIEQEKQEYVPPPTTRQTAAGASSRERTTSKSKEKSREKAATRTKSRGLDRRATHEEEWTNERSGLVEDPNQSVEMELDGEAEGLLNPALNRARSRHATRQRGPDDATAGARRGVGVTTTQAPNVPAESSRSRTTRFAGRRRSPARRGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1J6</accession>
    <name>A0A179U1J6_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDCG_06528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="BDCG_06528"/>
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        <property type="project" value="UniProt"/>
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    </dbReference>
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    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <end position="882"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="423"/>
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        </location>
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    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="588"/>
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    <feature type="coiled-coil region" evidence="8">
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    </evidence>
    <sequence length="1443" mass="162261" checksum="2414BA639C1DBF71" modified="2016-09-07" version="1">MTSISGSRPSRRAAAARKSFVVDETSEDDVASTGRATPTLSSHDEQEQEDEEEYTPVPKRPVAKRPSRRRTTASLSSETPQTAVQDKSKRTRRPRTGDDMEQSQILDTVDESTLLAENPETPSKRPSAPRKRREPSQQRRRRESQPQPQRQPQPQPQPQPQPELHPPSRCQSSAPLADITENTVNEATPRAQPEKEISTIEMINPMSTNLEKPMDIVLKSRSLAMPTVEEPSAPKPRMVITHLVMTNFKSYAGRQVVGPFHVSFSSVVGPNGSGKSNVIDSLLFVFGFRASKMRQGKISALIHNSANFPDLQFCEVEVHFQEILDLPEGGHEVVPESQLIVSRRAFKNNSSKYYMNKKETNFTTVTGFLKGRGIDLDHKRFLILQGEVESIAQMKPKAANEHDDGLLEYLEDIIGTSKYKAPIEEAAAEVETLNEVCLEKNNRVQHVEKEKHSLEDKKNKAIAYIKDENELAEKQSALYQIYINECDDNTRVTEEAILQMQELLNMELENHQGSEDAIKQLQRSYRRGAKEYEAMEKATQAMVKEMAKYDKESVKFEEKRKFLLGKQKKLEKAMQASRLAASECASLVEKHADDIERKTAEIAGLEKEMRHEEKELAAIREGLKGKTQGLSDQIAVKQKSLEPWNEKINKKQSAVAVAQSELDILREKSNAGAVALEEANAKIQSIQATISNKTTDMENRRAEKVELENETTLLETELRKFGQKEPEIRSRISSARQKADEARASLASTQNQGNVLAGLMRLKESGRIEGFHGRLGNLGTIDEKYDVAISTACPALENLVVDSVEVGQQCIDYLRKNNLGRANFILLDRLPQRDMSSVFTPDSVPRLFDLVKPIDPKFRPAFYSVLQNTLVAKDLEHANKIAYGARRWRVVTLDGQLIDVSGTMSGGGTRVARGGMSSKPVAEVSKEQVMKLEADRDEIERKFQAFQDKQRQIETSIKARRDEIPKLETMIQRIQLEIESSNRNLADAQRRVQELSVELKPSKSDDTRSAELQKHISSLQKEIETLHAETAGVEEEIQVLQNKIMEIGGVRLRGQKAKVDGLKEQIDLLTEEVSNAEVSKSKNDKLRIKHEKSRADAAGELEQVKGDLEKLAKDIASQDNDVYGTRQKTEEAQEALKTKQEELASLKAELDEKVAELNETRASEIEMKNKLEENQKVLAENQKRGRYWLEKLAKLSLQNISDLGEEQEAQSLPTYTKDELADMSKESLKAAIAALEEKTQNASVDLSVLGEYRRRVAEHESRSADLATALANRDSAKSRLDTLRSLRLTGFMEGFSTISLRLKEMYQMITMGGNAELELVDSLDPFSEGILFSVMPPKKSWKNIGNLSGGEKTLSSLALVFALHHYRPTPLYVMDEIDAALDFRNVSIVASYIKERTKNAQFIVISLRNNMFELASRLVGVYKVNHMTKSVTVENKDYIAMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1J8</accession>
    <name>A0A179U1J8_AJEDR</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_05573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAT01583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OAT01583"/>
        <property type="gene ID" value="BDCG_05573"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05573"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="167" mass="18545" checksum="4E46AB4B7BCE29BD" modified="2016-09-07" version="1">MGCGSSKVQRDNDPPGTSYNKPRPATRPNSHRTQSQRRLATGTGARNRTQPLSAVPKPHSSSKPRTHSQSTSSRTHLHTGARTRPSRTGTRRRHPTALGTIHDGQPPEDSAIREEINSFRLFIDQHAINFYRTQCDESGASISRYIARTIISNVIEKRSNGKRTALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1L6</accession>
    <name>A0A179U1L6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_05629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="OAT01603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01603">
        <property type="protein sequence ID" value="OAT01603"/>
        <property type="gene ID" value="BDCG_05629"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05629"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="600"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="620"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="657"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="693"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="730"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="766"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="802"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="838"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="874"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT01603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1053" mass="115616" checksum="1D7B3D1E4DEDCB23" modified="2016-09-07" version="1">MAFKNGLSERLEELRFSSPRSPPSDSPFSSYPSPTRGQPASYISAFHPPSDVRANLQRRFTTDASKLSSWPAFNNTQPLPFPESLDFLSSATQIHKSQLFEKKKAHIEYMREQRKRFEADMKLLDLQQEKERQELDQMARDLANANSSLAGAVSEPTTPPEYRDNGFPTAFSRPTRFSTSSATAPGVFNLFGPSQVVSPTGQAKSVISTAPSQASAPQSLLGSRRNSEEEYPPEPFPSFRQGASINRYSLPTSSFGSQSNSTTTTATATVNGFSRSIGLNPFHPAKFAFGDDDDEDRRGLKDDDRIPTPDVKSYLKLTDPDDKFPTLIRRDDNSGLLSANSAALDLANSRTPGPESYGHRHHASLPHNSLNMSQHVGNNRSQGEQISAPFSPTSDTRQSHRHSLEPGFSTYHNTQSLYCTANGSQSRPASLQMSYSTNDIPTKNNGYTAVTPPKSHSEHFHSHISSVGRVPATPHSHANDTTPASPMSPEREDQAFNLQPLQSVLQASATPFGPQLTSPTNGINGINGINGMPNGTSAMASFPNPVYGYAIQPFITSPLQANGQTQAFQPNPPYGSYINTAPYSPYARFPESPARNPGQGRRSGDGESVQFSRFGNAPLETYQGELYGMCKDQYGCRYLQKKLEEQNPAHVQMIFLETHIHVVELMTDPFGNYLCQKLLEYSNDEQRTALINNAAPQLVKIALNQHGTRALQKMIEFISTPEQTQTVINALRDRVVELVQDLNGNHVIQKCLNRLSAPDAQFIYDAVGTSCVAVGTHRHGCCVLQRCIDHASGEQRARLIEQITNNAFTLVQDPFGNYVVQYILDLNEPHFIEPICRSFRGNIPALSKQKFSSNVIEKCIRTADPQSRSALVEEMLVPSELEKMLRDSFANYVVQTAMDFADPEYRTKLIEAIRPILPAIRQTPHGRRIAGKILSVENQGRVSGGSSGQITPNDMTNVYHQIHPFPNSIITQYPQQQFNNVGDNMINKATATNSSSSSASSAANGSNSSANTPPATGNVNGNEGNSPTIYSPIPQQATNGINAFPVQGYPFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2J0</accession>
    <name>A0A179U2J0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_07151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02284">
        <property type="protein sequence ID" value="OAT02284"/>
        <property type="gene ID" value="BDCG_07151"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07151"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="335"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="928" mass="101187" checksum="6D94A682370802B0" modified="2016-09-07" version="1">MLSSHGKQLEAPEDGTINRMGELYNAILNYSVITRYFIYVTPLALLIAIPIVVGATVAQNAGIAGVRIVWFFTWVEIVWLSLWVSKVVAHYIPYVFQFLCGIVSSGTRKYALLLKALEIPFSLIGWSLTSLVTFIPLMTRNPSNRASGNTGIHHWQRVVNNVLFAAFIATLILAVEKILIQLISIGYHRRQFDSRIKESKRNIALLSMLYEASRTLFPEYCNEFEDEDYVINDSIVGGVGKFGRGHKRRGSPSPLRLIHGVGRVGDRITAAFGNVAQEITGKQVFNPTSAHSIVTLALEKRKSTQALARRLWMSFVLQGRESLLLDDIIEVLGSGREEDAKECFAMLDLDGNGDVSLEEMILTVTEIGRIKKSINNSLHDVDQAIHVLDSLLCVVVFIMVVLVFVAFLNTGFGTTLAAGATTLLSLSFVFATTAQEVLGSTIFLFVKHAMDVGDRVDIGDRQLIVEHISLLYTVFRGVRDHKTFQAPNIVLNTQWIENVTRSKAMREQITLTVDFGTSFADIQLLKAEMQKFVRDKENCRDFQPDVDIEVVGLGNMDKLELKIEIRHKSNWSNETVRAARRSKFMCALVLAIRKIPIYGPGGGDAVLGDVTRPSYSVSISPEQAQASKDEWAKGKEGKRMVPTDEMDNYFAGTKEQDGSEGTSTAVEGRSPGDGKPVYRGASTRSVPAKDKEASVVQALHSRPPAMDQARIDGCEIPRDSNTTPSKKHNGAGASDNGSGTSKPHRDGPPVARGTSTGRRTGVPATRFVSPKTPINEADVPTHTVPPTSAPPSLPAAAATAANPPLAQHPPPQPPPTTALPSTPTPEYYELTERDRHPSSYYSSSSPTADNPYLPPPSPHPCASQMQSQPLQPPPAVAYGGSGSRADNLPPPIAPGPGGGPLQQQPPRQLVPPPGGNAFALPPRNEYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2K3</accession>
    <name>A0A179U2K3_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="1">PRDH</shortName>
            <ecNumber evidence="1">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="1"/>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02336">
        <property type="protein sequence ID" value="OAT02336"/>
        <property type="gene ID" value="BDCG_07280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07280"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="398" mass="44648" checksum="D8AD1D322F3FAFA1" modified="2016-09-07" version="1">MDFLKQNINVLPNGHLVSRISDYIIYSVEAEVIDKIVAEYGPSTKVGAIVGGQTSCKAPELAAFDKYLPSDVEIISCHSLHGPNVNPKGHPLVLIQHRASDESLRFVESIFSSFRSKYVYLSGEMHDRITADTQAVTHAAFLSMGTAWHANSQFPWEVPRYVGGIENVKINITLRIYANKWHVYAGLAILNPAAKKQIRQYAQSVTELFKLMLGGHREELKTRVKTAGAAVFKSGTTQHDLLLRDDVLDQFSLSKGNSGRMPNNHLSLLAIVDCWWNLGIVPYDHMICSTPLFRLWLGVTEYLFRNEDLLDEVLDIAIDDNTFRSDDLEFTFAARAWSECVSFGNFASYRDRFEKIQSYFSPRFPEAVRLGNEMMKTILEKTAATDSSTPTASPTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2K7</accession>
    <name>A0A179U2K7_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="1">PRDH</shortName>
            <ecNumber evidence="1">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="1"/>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02335">
        <property type="protein sequence ID" value="OAT02335"/>
        <property type="gene ID" value="BDCG_07280"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07280"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="436" mass="48888" checksum="896FF19C20FAFF76" modified="2016-09-07" version="1">MLSFTNIYHQSTLIGPMADKRCRVNACDRPANYDALKQEFASDQNINVLPNGHLVSRISDYIIYSVEAEVIDKIVAEYGPSTKVGAIVGGQTSCKAPELAAFDKYLPSDVEIISCHSLHGPNVNPKGHPLVLIQHRASDESLRFVESIFSSFRSKYVYLSGEMHDRITADTQAVTHAAFLSMGTAWHANSQFPWEVPRYVGGIENVKINITLRIYANKWHVYAGLAILNPAAKKQIRQYAQSVTELFKLMLGGHREELKTRVKTAGAAVFKSGTTQHDLLLRDDVLDQFSLSKGNSGRMPNNHLSLLAIVDCWWNLGIVPYDHMICSTPLFRLWLGVTEYLFRNEDLLDEVLDIAIDDNTFRSDDLEFTFAARAWSECVSFGNFASYRDRFEKIQSYFSPRFPEAVRLGNEMMKTILEKTAATDSSTPTASPTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2L3</accession>
    <name>A0A179U2L3_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NCS2</name>
        <name evidence="1" type="synonym">CTU2</name>
        <name evidence="2" type="ORF">BDCG_05147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01407">
        <property type="protein sequence ID" value="OAT01407"/>
        <property type="gene ID" value="BDCG_05147"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05147"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="PTHR20882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="339" mass="37679" checksum="1C8994E1462E56B5" modified="2016-09-07" version="1">MEKYRPRNAEKNNQRKFLLPLSYGVSSSTLLHILNLQLERQISSGLGRRTYEIHVLNVGICGQPDNHRLDLFCEAYPLHTYTQVPLHSIFKYDTAIEDIISEYGGPEFRDDQSKMDQERLDHFRLSLSTAAARTDIDGILLTRLVVAIAKELDCDAILWGDSDTRLASKALSNVAKGRGFSAPWDVCDGMTPWGIQFNFPMRDVLKFELSTYASLALPKSLNVVDSERPSVDNLSSKNLSIEDLLAHYVETQGEKYPGIMANIVRTIDKLQAPAPDTGYKCVLCGMPVDMSGEDPSALGGSGGSQYVLEDRRERPMTGTLCYGCARTRLDLVPPKSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2L6</accession>
    <name>A0A179U2L6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle transport V-SNARE protein superfamily, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_05458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01539">
        <property type="protein sequence ID" value="OAT01539"/>
        <property type="gene ID" value="BDCG_05458"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05458"/>
    <dbReference type="OMA" id="QAYAVND"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="PTHR21094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAT01539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="189" mass="21482" checksum="18605936AA61E4FB" modified="2016-09-07" version="1">MTPSEDEIKAESQIHDILERRDALIAQLARLLDSESTLTSSALKQNNLSRHREILRDHRHELKRLNSAIAETRDRANLLSNVRSDINAYRSSNQNNNNAEAEYMLEERGHLESSHNMMDSVLSQAYAVNENFGLQRESLARINRRIVGAASQVPGMNSLIHKIGAKRRRDGIILGVFIGICFLAVFFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3I7</accession>
    <name>A0A179U3I7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartic endopeptidase Pep1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02625">
        <property type="protein sequence ID" value="OAT02625"/>
        <property type="gene ID" value="BDCG_07901"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07901"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="PTHR47966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="145"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="344" mass="37615" checksum="C70A42ADD51F2985" modified="2016-09-07" version="1">MYIIYPQVLAAFLSMEIVDVSGPDRVGHFLLPKSPEPHFSHACFTKIMRCLGIVNIAAAFLFTLASSGSIEKRSGFSIQQVSKCRPTPRSPMEEYAVAILRADHANHAKPKGVLDIINDLLDIIMYERSVNRTVSATPEPYDNEYLSPVNVAGKIMNLALDTGSADLWVFSSQQPLVERASHDFYTPLPGKLPMNGSSWEVNYGDGSFASGNVYIDRVSINDVVSPSQSIQAAQKVGETFIVDSNLDGVLGLAFPSVNNVRPEKQLGFFDNVKDTLPEPLFAVSLKKNKPGTFDFGFIDDDKYNGNITYTPVYDSGFWSISTTGYAIGNSTSNTSTPIKAFLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3I9</accession>
    <name>A0A179U3I9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02293">
        <property type="protein sequence ID" value="OAT02293"/>
        <property type="gene ID" value="BDCG_07171"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07171"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="SSF101233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="475"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="568" mass="64192" checksum="80F69AC0C6CFDD32" modified="2016-09-07" version="1">MRMRSHARLVLQIPVKKPTPVKEDGEDGDEVEKSKLLVVFDDSSLKYLEQFESTTQRDPEAEQARLDGAKAALAKVLSELASPPAPAKADEPSKVVDGEGDTPMKDADGQKDGSPAEVVTIPINVEDELSDIPAEMRETVAKEIAAFRERSNRRDLERLKREEELESLERARASGSRPSRLASPPPTAPSGPAGGANGIPLGPRDRGVPNAPSAPKGFGHQIPRDYQKGVSFVNGSGINGANEDEDTDASDEELERRRKDKKAIEAEKQYLDQERRWLNRERSRTAAVEREKNRDKEEDIRLQEEKQIMAKRLREWNDDVEASRKLEEYYADRGVWIRNRAAFRNREINMDEADRAAEERENARTQQQREQARGMADDFLARQAEELESRTQAPREPQRFKLSLGAAAQRAQATARRTVAEVEGLLEDEEDTGAATRRPLTSIKFDTAAESAGLTDEERAQAARQLAADIPSDKEGLWNWEVNWEFVDESVRGEQLKPFVEKKIMEYLGVQEQMLVDVVEEHIRKRGHPQELVELLEEALDEEAEILVKKLWRMIIFFSESEKRGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3K5</accession>
    <name>A0A179U3K5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02313">
        <property type="protein sequence ID" value="OAT02313"/>
        <property type="gene ID" value="BDCG_07207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07207"/>
    <dbReference type="OMA" id="CAQGAIM"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="435" mass="48478" checksum="8518E28EA8D83581" modified="2016-09-07" version="1">MSSHGEKNSDPNIEKPVDEEAIHEQSRAVSGKPWMYKRPKIGSFKFPYYASPTSQLLLVSFVCFLCPGMFNALNGLGGGGQQDPHAVNIGNTALYSTFAVIGFTAGSIANRVGLRWTLLFGGFGYFLYVGSMLSYNHNRNLGFLTFAGALLGACAGCLWCAQGAVMMSYPDEKSKGKFISWFWIIFNLGGVIGGLVPLAQTMNAPEGRAVGDGTYIAFMILMFIGFVLCFFLVESKYVRREDGSQVIVMKNPSWWSEIKGLGEVLVSDWYIVALFPMFIASNWFYAYHFNNVNGAKFNIRTRALNSCLYYLAQMFGAFAFGYMLDTPSLRRTTRARLGLVVLFIFTMAVWGGGYAWQREYTRADTGLEDFRIIDFKDSDYVGGMFMYILYGVYDAAYQTCVYWFMGALSNNSRKLANFAGFYKGLQSAGGAATWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3K6</accession>
    <name>A0A179U3K6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF protein, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01889">
        <property type="protein sequence ID" value="OAT01889"/>
        <property type="gene ID" value="BDCG_06290"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06290"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="151" mass="16437" checksum="5DF688CC2AE7D17A" modified="2016-09-07" version="1">MPHADSSYFAPGLSKAEVYSQVLEQAKGLLDGQRNWVSNLANVASLLWHAYAALPTPSSNVNWAGFYVRQDKFPSLASPDSDTKGTPNVLNWEGHIACDAESRSEIVVPILVNGETVAIIDVDCTQPSGFDDVDRQWLEALAAILSDSCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3L0</accession>
    <name>A0A179U3L0_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BDCG_05421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01531">
        <property type="protein sequence ID" value="OAT01531"/>
        <property type="gene ID" value="BDCG_05421"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05421"/>
    <dbReference type="OMA" id="YEGWKGE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="74"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT01531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="189" mass="21284" checksum="B9B4A7D33A9DDD00" modified="2016-09-07" version="1">MELHHAKHHNTYVANLNKALQDQMEAIKAGNIRDQVNLHAIISFNAGGHINHSLFWANLAPLGAPETKVDAAPKLWEAIRQRWGEDDGVFRQKFSEALLGIRGSGWAWLVRQGTQGPLAIVTTHDQDIVAKDEVPIFGIDMWEHAYYLQYLNGKAAYVKNIWAVINWKTAEERYLGGSVDAFKDLRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3M2</accession>
    <name>A0A179U3M2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Murein transglycosylase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_07215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02323">
        <property type="protein sequence ID" value="OAT02323"/>
        <property type="gene ID" value="BDCG_07215"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07215"/>
    <dbReference type="OMA" id="NVSHACL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="853" mass="92542" checksum="A16FD2BF0F526B0F" modified="2016-09-07" version="1">MICLDQENGGVNSLFDEIYIRQFPSSMGMAATGSKSLVREVSKATAQELSAVGVNWILGPVLDALTNARNQPLGVRSVGDDPQEVSAYGIEFMKGYQDAGLVTCGKHFPSYGNLDYMGSQSDVPIITDTIEQLSVSALVPYRNAITHGIDSMMVGGCSMTAGGMTVMHACLSEQVVDELLRKDLKFEGVVVSECLEMGALSHNIGVGGGTVMAMKAGCDLILLCRTFAVQQEAINGLKLGVENGIISKSRIRESLRRVLDMKSRCTSWEKALNPQGLSLLSKMQPSHTSLSTKAYSSSLTVVRDKHNYLPLSSILEPDEELLLLTPLIKPLPASAMLLSVATESGRAGLSADAASWERSASVMSGESVFKEFGRSLSRQRNGRVLHTSYTANGVRPVHENLINRASAVIIVTADANRNLYQMGFTKHVSLMCNSQFSPNGERRAKPVIVVAVSSPYDFATDLSIGTYICTYDFTETALQALVKILYGELNPTGSLPGSLSRNQRLQQSRQHWLVENWNEDRDAHALDTLLDIVREGSAQGQRSELASVTSTTFLLRNSDVEESHFVVRNSSTQALYGFCSTYYFKSTGTGAVGAIIVDPSRRRMSIGHSLHNRAIRTLVQRPGIRSFQLGSRLPGIYLGIPKGNPTERKKLRSWFVNLGWNTALSRSVCSMVLRNLENWSPPEGLTKVLQSSEVDYDLVYGWEYADSVLDHVKTTSRVGVMEIYKRGLGGAPGSGIIRAKRRDDGTILGTVVVYNSSSALAESMPALKDTRTVAGGISCPVISPSVGEYATLVQGLILLGIKQIRKQGASAAILDCVDADGNYDSLSSMGFSVLHSFEEVTCDASTWNIMVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3N9</accession>
    <name>A0A179U3N9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_06313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01908">
        <property type="protein sequence ID" value="OAT01908"/>
        <property type="gene ID" value="BDCG_06313"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06313"/>
    <dbReference type="OMA" id="CDIIEAR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107183" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="143"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT01908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="350" mass="38580" checksum="00CD33C3E9D98340" modified="2016-09-07" version="1">MHLQGALVILAALGVNGLPTLAPKALQEREGEQLVPNTGGCVIEKPWCTRADETGNARRQGNSQRPPTVKRQRNTEGFWPPSWPNPPKEGPPASETNNKIRTTIPLASPTSGSSPLRRRSAQTTPLERPDRPTQPGQTSSCNGWYDIKEGDTCDTVTVKFNIKMEQFLEWNPAVSKNCDKEIELNFSYCVRVLGSKRAKRTDPFTLTIPTTAAPSITPPFGNGIQARENNVHPVTVGPDGVLLPPNRARRMPTVTFDADQPHPVSLTPDGILIDPAPGVEVRPKVRPDGELPRPIRARATQIPEPLPELPPLFEPTQTPTDEDKSEKRNEIPEITRRQTIECARQWTVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U412</accession>
    <name>A0A179U412_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02775">
        <property type="protein sequence ID" value="OAT02775"/>
        <property type="gene ID" value="BDCG_08318"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08318"/>
    <dbReference type="eggNOG" id="ENOG502RNWT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEVSPID"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1013" mass="110755" checksum="6FA446D37E5C166F" modified="2016-09-07" version="1">MGLGSVDLTSSCVSVDEYHSYSDVPVPLPLFSPVPIRRTCSAPISRPASPPVSPAPTVLVSLRTISSGQVSGRLSLHEYRKTLSRPQLDEQSAPGPRRTLRRKPKTLNLTVFRPPRAPPSPPATPISASQISNGGSVEALQSWQPLAEAAIDHEEARVHENSPSHPLADAVSLPRTTTAFTAAPKTPSQQLETLLQSFPPPPPYTPATSVTSASPGMKKLNVFKYSLKQIPARFISHHRSSSDSALSFYPNHSRTRLRHRGVSFEILNPPKSPGLPVSFSPEHITPKSFHLLKRSIPAPSFDPMSSQFLDQSPSVSEASQGQQTPLKYGNRSRSGSEERRPTPPRALFEDLLTAHSSITSRIVNQRSNLFPLFPYIDHSTGDLDMELSLDTGTEEAHVTLPPNSPDPFASYSENEVLEQALEVQSPLQLKAPSLPAQDATENPKTTFANLILSGASLGQLSSYFTSKTLQTDRQPRGEVIKRHPSTLTKPRPPDPKQAFQWKKLRTGGASTLISSFVSRQLIPHTTRFRVEKRNTCEDGRKSRGGKPSTKTASNYRRSVSSPLERLSADVETLIEQNLVSATPRPKPSPAKSLLKVQYARPQSSVYSSIDEPPPELYTQTLADSARTDGAYLIDSCLSAEVPYKNVRSRYQWSSTLSPNFSKPIHPPESRQTGADAPVFPISYATSYQNRRPLDSHPINTIPDEPHNFYSQNSSIDVSEPILTVGGDPGTLQSSSVSGIADHDFLVDDYEDMGPGSSQTVSSPQLSRLGTFSTLRSRLKLPSTFSSRPKGNGLKPQTVSTNSSFKEPEQFADQLKTCSALESNTGLEDGWCSERVDAQDWQTVTGSHQFRSDFSRVDTGSSLANFSSCGSLANAEAQPWTSLPLPGGHQHFPSCPGNLVMVHPGQRGLSHKHKLHQNPNTGTSILLPDYQYPGKSFDSLNSVAKPVPVLKASTEVYPAPLPSTSQYQHPTPLNKPHVHPFKSPPPVLDKWKTRLRKQSLYQSSRFGPGPVNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4M2</accession>
    <name>A0A179U4M2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N,O-diacetylmuramidase, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N,O-diacetylmuramidase, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">ER-3</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02943">
        <property type="protein sequence ID" value="OAT02943"/>
        <property type="gene ID" value="BDCG_08748"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02944">
        <property type="protein sequence ID" value="OAT02944"/>
        <property type="gene ID" value="BDCG_08748"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08748"/>
    <dbReference type="eggNOG" id="ENOG502S19Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="110" mass="11356" checksum="8575A4713CD7677C" modified="2016-09-07" version="1">MSQELALLSSRPPKVPATKTRPSAATAQAPQRLALSAAATTSRTRASTNGAEQANYFLAHGGGWSDDGITLPGMLDIETNPNGNQCYGLSASSGSRILSARASARRAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4N0</accession>
    <name>A0A179U4N0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_06388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01941">
        <property type="protein sequence ID" value="OAT01941"/>
        <property type="gene ID" value="BDCG_06388"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06388"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="102" mass="11523" checksum="BD363DC3DDEF9649" modified="2016-09-07" version="1">MISLPAEPRFNTELPSELTQIQLLAEVLTGLKLTKGFLKQKKVGQFWIVSRRTLRVTSGDSRKLASISPREEAEDTMAVSYRILTMGQRPHRSGEFFGLMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4N2</accession>
    <name>A0A179U4N2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAS4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_08001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02663">
        <property type="protein sequence ID" value="OAT02663"/>
        <property type="gene ID" value="BDCG_08001"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08001"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016573">
        <property type="term" value="P:histone acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="PTHR38422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAS4" evidence="3">
        <location>
            <begin position="413"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="420"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="642" mass="71978" checksum="B12E2DEB34868CE3" modified="2016-09-07" version="1">MVARSTPTLRFSSVRHRDPPPPVAPSFDPSKIPSFAHDTTTTTTTKSIPPNPSTVTTRRSAVIQQRQRQQQKHHQLQDKLKPLKQSKLPFPLASSPRQPQQPTKTIPAPERPFKKAKLDGRHHDQASITGPAKLPLRSRDSQGLLLLTPDSSSTKTTSSTTTPAASRTRSANATAATAAGVSSSTGGGGGLTAINKNNSKPTTLALSAPPRSPASAVSRTTRKSAHSNQQQQHHTPVGVSEDVAQEERRKKKKVVNGIMIADDHDNDNNDKYKNDRIVNNLLKDDGASPSTTAAVGREKRSLRSNDGGSRSKSELAMYFQNYEQILSLEPMKPEFLSADTTVLLIDDLTQPIELDPVPTNAPATKLRGKHDKGNPPNGQMAQSLMENPLLELHDAQILDLRPSTHHSKKPSKDPLDGDVYFKAHRRIERQEKQLRNIERERAQHEKVQLDRLLDELQGHDWLRVMGISGITETEKKLYEPKRAYFIKEVSALIDKFRAWKEEERRRKIERDQYLAEEDDDDEEEDEEEDENEENETEDEDEDEAEQAADQTSIGKEDTRPQPNRDGDLEYFSPNFQTYALQQHTHPHRHPPRHHQQQHNNRRPSQNPNRSHRSIRNGTCATPPSGKSDGAAHGPRSGSRCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4P2</accession>
    <name>A0A179U4P2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_08050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02673">
        <property type="protein sequence ID" value="OAT02673"/>
        <property type="gene ID" value="BDCG_08050"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08050"/>
    <dbReference type="eggNOG" id="ENOG502QTNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="290"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT02673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="518" mass="59019" checksum="91AC7A5669AEAE7F" modified="2016-09-07" version="1">MDSTSDRYPFDYLLPPVLVSGSRDPTSVHVLFYSVCASLTISTIQGMGIGTFLEPLVVITLLVGGTWINRSSEISRPFTHDTTRPSSVTSDEFTDKTVGSVEDGLSTTTSTHDGSMSTHLYCSLSPSLLLDQEPPWRTRQIWLWSWKREVMTPNTAKYRNRCFSRFLRRFPFLVECWYWTLVYWTYQLARAFTAVTLQDATVDIARKHALQLIKLEESLHIFWELHIQHYFLHHPILLTCTNWLYSFIHIPGTIAFLVWLYYCSITRNRPADRYSMKLEGYQSNVLTGSELYQARRRTLAFCNLLAFVVFTLWPCMPPRLLSDRSVTGLVGEFSRSYGFVDTVHGVGGASSVWTQNKFCNQFAAMPSLHFGYSLMIGITITTIPLPSEHTRSRALLPHFLNFSLPGLASKIRPLAWERIVAIVVGITYPFTILVAIVATANHFILDAFAGAIICGLAWWGNSVLLNLLPLEDYLFWILKIHKPEQGSHCLRPSLVFDDCDGDHVKDAMNYQITHKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4P4</accession>
    <name>A0A179U4P4_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2013 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02780">
        <property type="protein sequence ID" value="OAT02780"/>
        <property type="gene ID" value="BDCG_08327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08327"/>
    <dbReference type="OMA" id="TQLKYPP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="PTHR13357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="DUF2013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2013" evidence="2">
        <location>
            <begin position="189"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="767" mass="85047" checksum="F89DFA27C0AFE042" modified="2016-09-07" version="1">MELEAPHNTLEGANALWDEFDAIFHMPCDTHAAIDNVLRAYLELTTKYKDTLVSSENEISHCLERLLASELFVANADYIRRQIIYSLLQDDAPDILYVTVSFLLFDGRQNEHTFEMMNKEGAFVRLLELIQSQERLDGDGAAGLHRLLMNLMYEMCRIQRIKIGDLVLVDDDFVKHLFEIIEELSGDIDDPYHYPVIRVLLVLNEQFMVSAHDPLPERSSSAPLTNKVIKVLSMFGSTFKTFGENIILLLNRETETSLQLLTLKLLYLLFTTPPTYEYFYTNDLRVLVDILIRNLLDLPEEAAALRHTYLRVLYPLLAHTQLRYPPHYKREELRKLLGILVRGEFSFDSEECERILHFDDVDETTKRLVLRCGQVDWLAEHEVPEQKPKPESIAEASMGKYIEETGSPTTTSSTSPEPSSPHRLSRCRSSRVKSSPITLKPAKELGMNLEIARSSEASVVEVAAHKEKPGVMVPSRNAAPKAPPAPPPPKQKPQPPKARRWRGRREQQEGDESSGQKTADGAQLAALGRNSPDSRKSSGSSGSAPPPTTPTDSVRTSGDMSSTRTAADELLVPTIVVPKARTPNPPTTSHAPALPPPRRSSHSVPPKCHGSPHSIPHRHRQPPPPPLHHNPYNSEKLNPAFQSPCSTHLPPSPVSPATSPSNGHITPSQKPEPPKTRRWRGKSSQQIVDGKPPGDAAPTTGNTIAHNNDNIDSTEKCNGLRSDHERRAVAASLLETTATCAHDTTGGAESVNRIEDGVGRLKVGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4R2</accession>
    <name>A0A179U4R2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01971">
        <property type="protein sequence ID" value="OAT01971"/>
        <property type="gene ID" value="BDCG_06439"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06439"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="405" mass="46150" checksum="F5FC9639A8D005FD" modified="2016-09-07" version="1">MESFLARPKTLSLRRTKSSASLSVASESSSRGAKSSPYCDKNCELFLETKRSFLYEHEDGISYESRTLCRQLLENTPKVPRGTRFDDDVFESTCRRVQRKNETGVSILITELIVPFAEDTIYSHNVKFPRFIESFNEGWDSSIPLDDVQRLPQSGQLQRFRLPRPQPDHAVGFARQSFTEGHLKKLAPFVGEIGDTSFFLGTAYMYFPFLTSEVKCGKAALDTADRQNAHSMTLSVRGIVKLFRLVKREKELHQEVQGFSVSHDHCSVRIYGHYPVIDGEETTYYRHTIHKFDFTALDGKEKWTCYRFIVSVYGDWAPSHFKKLCAAIDELPEFKPEELQQSEQSLSEATTGLSQEIGAVGLGSSFTSQLEEECEPLPTSRNDDLGNLRPNEKKSKQGVPRKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U504</accession>
    <name>A0A179U504_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_09110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">ER-3</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002629129.1"/>
    <dbReference type="EnsemblFungi" id="OAT03084">
        <property type="protein sequence ID" value="OAT03084"/>
        <property type="gene ID" value="BDCG_09110"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03085">
        <property type="protein sequence ID" value="OAT03085"/>
        <property type="gene ID" value="BDCG_09110"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09110"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:cellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk/HKT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAT03084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="733" mass="82556" checksum="5A439A3B28571EA3" modified="2016-09-07" version="1">MHTFQQVVIYMVPMIGNLSVINLVVVLVRLYWFETRFKDIVRLSRQRSIDRPRSSRLHSSESRGRDSITLRDRIRDIRVLRPEPRIGSRSRTAASEAEGLRLRARILSNMPSNNSNSDKDKDNENENDNRNEAVPNVNENAKISTVENDGTTIFPSTPDLSASPDPQPLMLDQISSSPDKNNTERSAPSAHISFSAETNMEPRGRALRIPGPREFESGQTVREVDDDDLMKSITIEESLSAGPSGETERRRLPTMGRLLSHAASVERAASNAFILGNSSRKRSRSRSSNPLNRSSSKSERALLDMSYLSYQPTIGRNSKFLDLTDEQRDELGGIEYRSLKLLAKIVFCYYVFWHIFGVICLIGWIHNSDRKYSDYVRSVGQNPTWWAIFSSMTAYNNLGFTLTPDSMISFRNATFPIFIMTFLIYIGNTGYPCMLRLIIWIMFKISPRDSAIREPLNFLLDHPRRCYTLLFPSSPTWMLFFSLVFLNFIDVLLFLVLDLQNEEVLAVPSSWNRFLAALFQAASARTTGTSTFNVAKVHPAVQFMLMVMMYISVFPIAISVRKTNTYEENSLGLYDPQSDEIDESNSTASYVGAHMKKQLAFDLWYVFFGMFILMITEGSKLADKSDPEFAIFSVFFEAVSAYGNVGLSLSHPSISSGLTTKFSVLGKLVICALMLRGRHRGLPYELDRAIILPSERNLTDSSSTKDGGAITTALPSANTTIGPLSRVRTAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U505</accession>
    <name>A0A179U505_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_09110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03086">
        <property type="protein sequence ID" value="OAT03086"/>
        <property type="gene ID" value="BDCG_09110"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09110"/>
    <dbReference type="OMA" id="GNTAYPC"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:cellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk/HKT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAT03086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="723" mass="82071" checksum="91E665429B33FE6C" modified="2016-09-07" version="1">MRLPRLNFIRLHYAYILLLNVLAVIIIYPAKNLSGIDAFFTSCSAATTTGLNTVDVNTMHTFQQVVIYMVPMIGNLSVINLVVVLVRLYWFETRFKDIVRLSRQRSIDRPRSSRLHSSESRGRDSITLRDRIRDIRVLRPEPRIGSRSRTAASEAEGLRLRARILSNMPSNNSNSDKDKDNENENDNRNEAVPNVNENAKISTVENDGTTIFPSTPDLSASPDPQPLMLDQISSSPDKNNTERSAPSAHISFSAETNMEPRGRALRIPGPREFESGQTVREVDDDDLMKSITIEESLSAGPSGETERRRLPTMGRLLSHAASVERAASNAFILGNSSRKRSRSRSSNPLNRSSSKSERALLDMSYLSYQPTIGRNSKFLDLTDEQRDELGGIEYRSLKLLAKIVFCYYVFWHIFGVICLIGWIHNSDRKYSDYVRSVGQNPTWWAIFSSMTAYNNLGFTLTPDSMISFRNATFPIFIMTFLIYIGNTGYPCMLRLIIWIMFKISPRDSAIREPLNFLLDHPRRCYTLLFPSSPTWMLFFSLVFLNFIDVLLFLVLDLQNEEVLAVPSSWNRFLAALFQAASARTTGTSTFNVAKVHPAVQFMLMVMMYISVFPIAISVRKTNTYEENSLGLYDPQSDEIDESNSTASYVGAHMKKQLAFDLWYVFFGMFILMITEGSKLADKSDPEFAIFSVFFEAVSAYGNRVRKISHLRLDASWSTPRIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U520</accession>
    <name>A0A179U520_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="OAT02081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02081">
        <property type="protein sequence ID" value="OAT02081"/>
        <property type="gene ID" value="BDCG_06701"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06701"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="254" mass="27751" checksum="9FDD2E27370D24F4" modified="2016-09-07" version="1">MASTFRLRLLGGPRSLRPWVCKHCRALSSSAIVQAGHNRWSTIRHDKGKNDAAKSKERILYARDIINASKLFGPDPASNPRLALVISKAKRSGMSKSTIEAAIARGQGISPTGAPLESVTIEALLPSSVAVVIEFTPTSYLFEKKGRIVFEKVEGLNVDDHLEHAIDAGAIDVDTDDQGRLRVFAEYADTKAVGDKLSALTGLKIETADIIWDPNKDTVVELQSREDADKIEEILSAIREEPTVQDIYTNSTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5P1</accession>
    <name>A0A179U5P1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING finger domain-containing protein, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_07149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02281">
        <property type="protein sequence ID" value="OAT02281"/>
        <property type="gene ID" value="BDCG_07149"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07149"/>
    <dbReference type="OMA" id="VLPCKHQ"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107205" evidence="4">
        <location>
            <begin position="31"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT02281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="680" mass="72164" checksum="39400362994820A3" modified="2016-09-07" version="1">MHILPSSLAEVVMPLLWICAFTLLSMPAQAQVSRPTNDSVDTFLPITKYELLTMQLTLGPIGLLPLSTALRRLFRSLIESRFNITGTLVIIDANNATRLNGSDIALVSCDASVSSGESDVDDALRLAITGAFTPNAIILYSTESSHCSYSPGALNWPPFMNIFTITSSLAASELTTALLSGGRAFGESIIIPSMDMGSSRPGSGGQRNNVAMIILYSITGIITALFLTVIITGAVRAHLNPDRYGPRNTAGRPRQSRAKGIARAMLETLPIVKFGDPEDERAPTAKQDLELASNYPDGEHDHRRSDARTDGVTTPKTRQVDQHQQQLQPVAPQQERTATSATVASTSHVVANTVKEQDEGVIGPASPELNPVNQDQLADSGTLGCPICTDDFVKGQDVRLLPCQHKFHPECVDPWLINVSGTCPLCRINLNPEEAEPEPDVAATPTSTPSRATTPTPPSTLARHSGHSHHHSRTPYARRYRRVSTYFVPASTRGMILDTGTENDSAEQEHQRQRRLYTLRHMRGSSEQHRTNDGNNNVTATGAITEASSSPAVAEGSGQGQMDEASRRNRLSTWLRERFRVRTRRHGESDGDDDGGGGAGGAGAGAGAGAGGIAKPGTSTQTDTDATATASASASASASASRSPAANPSGDTDTAADISIPTTSTPTTPIQQPTTSAAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5P8</accession>
    <name>A0A179U5P8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS drug transporter, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02638">
        <property type="protein sequence ID" value="OAT02638"/>
        <property type="gene ID" value="BDCG_07922"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07922"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="378" mass="40634" checksum="537A636005447EDF" modified="2016-09-07" version="1">MEQNNASLATIINSDMIPFKDRGMYQAVQNVLHGFGSICGASLGGSIADTIGWRWCFLLQVPVSILALIVGHLVVKNQTHYDNSDYETSPKATLSAIWNRVDLSGAFLLIIGLSIQLVGLNLGGNELPWSSPWVILSLVASVLILGLFLYVEATTSAMPVIPLHMLRGKLAVSAQISNICVGLAAYAFLFMLPLFFQVVLKDSASTAGARLIIPSLAAPVGGVISGFVMSRWGQLANLVRLGALLMFIGNALVMLLGFDSAKWKYITYIIPASLGQGIVYPAILFTVLAAFGHSDHAVSASTVYLIRSLGTVWGVAITSAITQNTLKRRLPEALIGIPNKWKVILFSFSSSLFLKPTTLLLSSFSQPHPPVSSFVQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5P9</accession>
    <name>A0A179U5P9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02291">
        <property type="protein sequence ID" value="OAT02291"/>
        <property type="gene ID" value="BDCG_07170"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07170"/>
    <dbReference type="OMA" id="KSACYPV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107208" evidence="2">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="271" mass="28608" checksum="B4F78C87272D5881" modified="2016-09-07" version="1">MRAQFFAAAALLATSAVATNTWTRIASPVDNLNALRVRQSGGSFEPEGRKGSGDTCKEAFGDGYLQCGTSQSCFNPNLGHSCCDGYVCPSGSSCLTNGRCCPDSEGPEACLGKLTKSNLPTDIPPATPTEYPTETPTETPTETPTEYPTETPTETPTEYPTETPTETPTEYPTETPTETPTEYPTETPPDDHCDAPTDYPTETPTDLPTETDTPPYPTLSQPEPSYTAHPTGGSPNMPSETPPYDGGANSLKVATGAAAVLGFLSFMQNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5R1</accession>
    <name>A0A179U5R1_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein sip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_07197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May negatively regulate the SNF1 kinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02301">
        <property type="protein sequence ID" value="OAT02301"/>
        <property type="gene ID" value="BDCG_07197"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07197"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PTHR31315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="709"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="777"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAT02301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="791" mass="86050" checksum="E65A1AB8B3A8931D" modified="2016-09-07" version="1">MGNTATKEARPPVGTSGRSGHGRGSSGGAVTFGGHSRFHNQSDGSHPGGSPRHFRGSRPDLSFLGIGPAVERDTVVERKETKQERDARRLARERAVRIKERERSMREEHVDGGYLVTQGVYTGTEDFNKAVVRQLMIERRLAPFWKGLEEFSESWTEHQLMAAAKGLPIPAPDEIPPELEYKLTPPRPPEERDLPEQNLNNLTVPITSRSQSYNSDTSFSAHPVSPSISLQPQLSPSGSGSPGPHLFRGRAKTLASPTASSKNSSLGEMSPREIQLPKDPFVNGQPIEAYLYKNPIECPICFLFYPPYLNRTRCCDQLICSECFVQIKRANPHPPEHEHRDSSLPPPPDQPEGQLISEPAACPFCVQPDFGVSYVPPPFRRGLSYLPSNGLNNTLTSPASSTSSVASRNANPQSITTRCRANSLSANSPTVITTDKIRPDWAQKLQMARAQAARRSAAATALHAAAYVNAMSNPSESRGMASSSRHRENDPLAESTFNLAPARASSRRSRVDELEEMMMMEAIRLSLASEEERRRKEEKEAKKEAKRREKEAKRAEKLARKNALYSNNPSSVALDAAGNSTGRPDREPPLPVTVHEPSNDKGKAVDRPASSSEPLHNDPQPPSLPALHIRPSEDDDLSSVFAPSSASAANRSHLRHLSSTSSSNSSLVESTSGELIGSTSAPNSTNSAIEPVLNFRSLDAVIGDEDKSCNEHLEGVTSAKETQQPSTDDATRSSTNPNLEPEVEPAPSEHVSPVQEGPGLNKDEDGFGDKELQSHSLEITCEGSANMETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U5S1</accession>
    <name>A0A179U5S1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_09287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03160">
        <property type="protein sequence ID" value="OAT03160"/>
        <property type="gene ID" value="BDCG_09287"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09287"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT03160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="290" mass="33640" checksum="4361242C27BCD07D" modified="2016-09-07" version="1">MLVDVTEKIGDVISRRQQSTLEEELRQQPSNSVRIAFAGMKKDCEKWIANNPNAITKLPIPHQFWATCTEDLNGCSNAIYSHGGYGELVNLDTWSCFKLKEASSDKKYVWYQMTMFIRWNPIKQTTFIFCSDFLQCLRDGLNRRISSVGPSDPFTWHASFVDELRLLYDNFFWKFRNLVRDAEKERNEPQATGPNFPRLHDIARHVIHSVEILDVAIETVDSILHEHDLFISNEGSTVAFPIPDLKANDVTRRLYYHSRELRAIKARSASLYDRLKNEISLVRSLFYGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U617</accession>
    <name>A0A179U617_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02739">
        <property type="protein sequence ID" value="OAT02739"/>
        <property type="gene ID" value="BDCG_08220"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08220"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097027">
        <property type="term" value="F:ubiquitin-protein transferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904668">
        <property type="term" value="P:positive regulation of ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="PTHR19918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="912" mass="98627" checksum="7C74A043F8152DB0" modified="2016-09-07" version="1">MLSRCQSLEELSSSRNGDSLSLTLVPDSPVEQTISGPASTASSPEAQSLGSSSPTSSQVNVDSSPSPTLESITSPGSSRNITSPLSDSYFSQGKKPDGVEVDHSPVRSGLLNTLERRRSLIRSPSPVARKRFLSPDRFIPAREPYATDVPAFRLSKNPRLLSPGEKLLRRRDPRADPFAPYQPRRRAGLSRSSRSSDRRDTPHHLPRHVSDTSVYARNDRPAGRGNQRQISAGAVWNVGGTAAATGRAPVGVDNGRGGLISTGTNAPMYIANFLDKDTHIQHLKRHESRLATALDIDQANKVLNFGDPSLFMDPGYLAEAAQLEKYSPYVWKHSSWIRANSNTLHKSTSKPARSAVPSTPFRVLDAPLLRDDFYCSTLAYSYTARLLAVGLSSRVYLWSEILGVQYPPLAPHLASNYVTSLSFSSPQGGKSILAIGRHGGQVSLWSTFDTDVRFEFYQRTAVSCVSFKQVTTKRQSTRFQGLVVDTEDLVVGDDAGNVWYYSVEWPDSKTRDRHGWNGATTLIAKISAHTQQICGMVWSPDGKYLATGGNDNACLLFDIPDILGKSDRNGQPSSSVETTNPPASPQARGSLSRFPYHSNLNRIFDWGRLNQFSIPHALSSAPSSGVAQDSAPRQAGFLGSRQHQTIFIPANRQKYKFHHSAAVKAIAFAPWQPSLLATGGGSNDRCIHFFHTGSGACLATINVHAQVTSLIWSKTRREIAATFGYAQPEHPFRVAVFAWPSCQEVVAIPWSPAPDGVAGSTDLDNSHDCGRALWAISYPGGPNDMTHTGADERVPSTSSSSSTVIAAPHNPATGDGSNRSNSTGSSVNTTSTIVASSPITRPRVAYREGGTWWSRTAEEGCIIVASSDECVKFHEVWSGSQKSTAGATGQLGGSPILESLEGIDREGSEVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U618</accession>
    <name>A0A179U618_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinesin family member 11, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_07451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02421">
        <property type="protein sequence ID" value="OAT02421"/>
        <property type="gene ID" value="BDCG_07451"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07451"/>
    <dbReference type="OMA" id="NGVYMTP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="80"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT02421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1086" mass="121845" checksum="3794215C77CDDC55" modified="2016-09-07" version="1">MVGATRSQAPARSLRSGMIRPPQRTTRASILSERADSPATALRPSNTNTTRSIRSPSVHPTTGLKRKEREFEPQPVQRTNIHVVVRCRGRNDREIKENSGMVVSTQGVKGTNLELSMGPNAMGNKEYHFDKVFSPAADQSIIYEDVVAPILNEMLSGFNCTIFAYGQTGTGKTYTMSGDMDDTLGLLSDAAGIIPRVLYSLFKKLEDMEHSVKCSFIELYNEELRDLLSSEDGTKLKIYEDGAKKGNHGTMVQGLGETYIHSASAGIKLLQEGSHKRQVAATKCNDLSSRSHTVFTITVFVKRKTEKGEEYISSGKLNLVDLAGSENIQRSGAENKRATEAGLINKSLLTLGRVINALVDGGPHIPYRESKLTRLLQDSLGGRTKTCIIATVSPARSNLEETISTLDYAFRAKNIRNKPQINSTISKKTMLREFTTEIEKLKTELIATRQRNGVYLSSAAYEEMTIESESRRILTEEQRAKIETMEANLKNKVQELFTLTSNFNDLKKDNDSTKLLLDQTEDLLEKTDIVLNNTKRSLEEESMLRKAHEETEESLYNIGTRLISTLGKSVSDVDCLHLKLRRRSDLHTLNRKIWQSSTSEVLDMSKVVDERIATFQYKQSKLLEDLTIRMEDFVAQELERVKAGHSLISQSETSFENVETATKAHTTECRDEMNEVLEEIKILREDVKQRVGEGLSGLSTAAERISGEVINELGQFHRQLHSSYISLGEEFKSVIDTLVSSLHSQKDDIHRLRKLVHEANTQAARASEDAMLKLQTTLDEERTAAETERATLLSGIKMLLDKSGKTQSARLDTKVNNIRSDMAASHALLKEADVEFGEHMDEWELQENKVITEALASESTIQKRIDDDWMNFGARNNKIQETARAVHRETEMIVNTQMEGIATQMQALDAFVMRARSQNDSHHESRISTLENLGCNIRESYKDIHNTLDVFGTQATTFRHEILDENEVIQEPIDNLTVDIRKPLAELQSNIQSKSLTEYTKTGETPEKTQYDYPSTLPRTEPHDSLIARIRGTKEQHENSTNTDASATVPSSPGLCSPIKSPTKAMVYQDGGNEGGRYKRRRETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U620</accession>
    <name>A0A179U620_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BAR domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01942">
        <property type="protein sequence ID" value="OAT01942"/>
        <property type="gene ID" value="BDCG_06390"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06390"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="SSF103657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="300" mass="33133" checksum="B0CA4609858380AE" modified="2016-09-07" version="1">MDKVQAFGKNISASFTPFAARTQQYVKEQLGTADEKTQLPDDYIELEKRVDALKLVHQKLLQVTSQYSNEPYDYPPNIRESFNDLGRTISEKVQLLSHATSPAEAQAALTAPPSAKPQPKTFSHAIARASLAGSQLISQTHPSGSEDPLAIGLEKYALAAERVGEARLAQDAQIQSRFLAGWNTTLNTNLMFAAKARRNVENARLMLDSIKARKGVSKGDLDSLSEEDRAEIEQAEDEFVGQTEEAVGVMKNVLDTPEPLRNLADLIAAQLEYHKRSYEILSELAPVVDGLQVEQENTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U629</accession>
    <name>A0A179U629_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_17961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999987">
        <property type="protein sequence ID" value="OAT03173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03173">
        <property type="protein sequence ID" value="OAT03173"/>
        <property type="gene ID" value="BDCG_17961"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_17961"/>
    <dbReference type="eggNOG" id="ENOG502RR03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT03173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="364" mass="40888" checksum="420E4ADEC6329ECD" modified="2016-09-07" version="1">MNGNQVEDTSEDDLVEAVKAFNSVEKDANGAYRVFRKQVLALKLRALEANAGNYCAGKSIKRDSRVIVYVSEKCWSNLPSTAQKSKTTNLARWRGHGEKWLSLVEPSIPMSFRHIPSDHRCFGDFERRRRQTPEFDAVISTLQAVCIIPDLRKLWCRQLIRKRTESIGPQQSDPAMTTNAEDLAAQSSHVSITFMPTGGQMRRPSNRSHHSFMRQRHIRSALAGSKRPRTLSDDDEEEERGPSPIVGGVSISLANNNGRPLVSNIPMPSAEMLTSHVPPSHVDPCGALAQQDSCIESMRRAEFFDLMRQTNTADSLSQMNLDLSRQTNTADSLPPVDFDLSQQMNMSDSLQHEFDLMQQSMLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U630</accession>
    <name>A0A179U630_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 finger domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_08017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02667">
        <property type="protein sequence ID" value="OAT02667"/>
        <property type="gene ID" value="BDCG_08017"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08017"/>
    <dbReference type="OMA" id="EERGPWL"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="685" mass="74973" checksum="3763CCDAEB8C5309" modified="2016-09-07" version="1">MLALERSHHEQSYLQQLSMDPSMHDPFGSLNIDGYNHLGFNPFPVGTASFIATPSFLVEAPQHLYGNNISSEQHDNQKYDSYAHHPSASPSIATTLSSDLSASTSSSVSGPSLPSTSSSTIGSPYQDSWIDMNSASGLGPATVGSDGYPQEYVSAGMEADMMFAHEKLPDSFVDPSLIQPMQQQSSYPPPTASYAEEIQYAFTRSPLFHSTSPAASPLPQSQTLHPQQHPRSALPSPYLTQSFTPRPLSFAGRRSSISSENSRRSQRSPLAGSVDYEEKGKEKGRCPHPDCGRVFKDLKAHMLTHQSERPEKCPIVTCEYHLKGFSRKYDKNRHTLTHYKGTMVCGFCPGSGSAAEKSFNRADVFKRHLTSVHGVEQTAPNSRKKTPPTSNRKAATYCHDATGKCSTCSSTFSNAQEFYEHLDDCVLRVVQQEEPSEAINLKRLTEVASDDAVRQTMEKHMLVDTTNDVITNHNQTDDHDDDTNDSNDNNNSNTRNPAAGKGSLKSSASSTSTSSTNTNTTPSSSSNTLSKPPSTTHTTAGITKPRPTSSRRRNNRNNYPPSWGCATNKMKMKKRVLCLYDGQRRLWKDEMMLDNEFEVRLKLLGGANDDNGTGRDAYVTDLDVETLKRADAVHGATEEERGPWDGDMGGSAGLVGLMGPAAVPLMRHMPEGGMVDEVNIDELMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U633</accession>
    <name>A0A179U633_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_08326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02778">
        <property type="protein sequence ID" value="OAT02778"/>
        <property type="gene ID" value="BDCG_08326"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08326"/>
    <dbReference type="OMA" id="WNSGHAS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="556" mass="62621" checksum="11FD6220B96B7E8E" modified="2016-09-07" version="1">MKSRFSLKTRLEYYTNCEGLYKEAYETYLKKGQPCLVPGLGLRSEILLPKSTLRWLVTQSDNILSMREAFRELDQIDWAADHHKYVTDAWLTPILNRDVNRNLDRYLPPLGKEVQNAVERRIPNKGEWAEIPLWDTMKLVIAQISSQFTVGEPLCRDEEYIRASSSFVDTFVTNAGLVPFVPVPLRPILCPILYLPLRFKTWKLERILKPLIKQRLERLLTHQQPSKGKNEHLHDITSCKDTPDDLLQLMLCFAQNERSREEFHNLHSLAYRICLNNLGSFHQSSAAVTNMIFNIIASDKEFNTIALLREEIGSVLPSECYTIPPSTTQPVQNNKKKYGWTKASVAKLVLMDSVMRETTRVHSFVHRAVARSVVADNVHSPVIEGEADSNEPTTTSAPLPKGAMVSILSRGAYFDPDVFDDPMKFNPWRFAERRERHAKVVGGRGSDQHASDRIIAANDTRTTTAAAAGAIETFTVTSANNLVFGHGRHACPGRFIAEAEIKMLLVTLLMNYDVGLLPVPGADGKGEVAVRPESPWILEVVVPPIKGKIMAKRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U656</accession>
    <name>A0A179U656_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="OAT02779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02779">
        <property type="protein sequence ID" value="OAT02779"/>
        <property type="gene ID" value="BDCG_08327"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08327"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="PTHR13357"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="DUF2013"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2013" evidence="2">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2013" evidence="2">
        <location>
            <begin position="254"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="735" mass="81225" checksum="8320BC2F730D8825" modified="2016-09-07" version="1">MELEAPHNTLEGANALWDEFDAIFHMPCDTHAAIDNVLRAYLELTTKYKDTLVSSENEISHCLERLLASELFVANADYIRRQIIYSLLQDDAPDILYVTVSFLLFDGRQNEHTFEMMNKEGAFVRLLELIQSQERLDGDGAAGLHRLLMNLMYEMCRIQRIKIGDLVLVDDDFVKHLFEIIEELSGDIDDPYHYPVIRVLLVLNEQFMVSAHDPLPERSSSAPLTNKVIKVLSMFGSTFKTFGENIILLLNREMLVDILIRNLLDLPEEAAALRHTYLRVLYPLLAHTQLRYPPHYKREELRKLLGILVRGEFSFDSEECERILHFDDVDETTKRLVLRCGQVDWLAEHEVPEQKPKPESIAEASMGKYIEETGSPTTTSSTSPEPSSPHRLSRCRSSRVKSSPITLKPAKELGMNLEIARSSEASVVEVAAHKEKPGVMVPSRNAAPKAPPAPPPPKQKPQPPKARRWRGRREQQEGDESSGQKTADGAQLAALGRNSPDSRKSSGSSGSAPPPTTPTDSVRTSGDMSSTRTAADELLVPTIVVPKARTPNPPTTSHAPALPPPRRSSHSVPPKCHGSPHSIPHRHRQPPPPPLHHNPYNSEKLNPAFQSPCSTHLPPSPVSPATSPSNGHITPSQKPEPPKTRRWRGKSSQQIVDGKPPGDAAPTTGNTIAHNNDNIDSTEKCNGLRSDHERRAVAASLLETTATCAHDTTGGAESVNRIEDGVGRLKVGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6V5</accession>
    <name>A0A179U6V5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AT DNA binding protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03039">
        <property type="protein sequence ID" value="OAT03039"/>
        <property type="gene ID" value="BDCG_08978"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08978"/>
    <dbReference type="OMA" id="HIAKESP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="2">
        <location>
            <begin position="148"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT03039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="310" mass="34170" checksum="6C4A2D9A1922851D" modified="2016-09-07" version="1">MPPKRRQSTTVVATATPNELSQNDAKKPRLSSRNPVSPVAQTAASSRPKRASRAHAGKEYSASEPSEGIRKRASGANAGKTKQEEADSVTSSAPGTKQKANKCVQSATTKAKQHGSGAVVSLNGIETEPKNKNTVDETQDEADDTKSHWLMKAEPESRIEKGIDVRFSIDDLRGASEPEPWDGVRNPTARNNMRAMKKGDLAFFYHSNCKVPGIAGIMEIVREHSVDESAFDPAHPYYDPKSNRENPKWELVHVEFRRKFRDLITLAELKSFAKPGGPLENMQMMKQSRLSVSAVNGKEWRFIMGLAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U731</accession>
    <name>A0A179U731_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High affinity methionine permease, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_08262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
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            <taxon>Eurotiomycetidae</taxon>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
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                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="gene ID" value="BDCG_07200"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U735</accession>
    <name>A0A179U735_AJEDR</name>
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        <submittedName>
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        </submittedName>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Eurotiomycetidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
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                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
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            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0004556">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107212" evidence="8">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="9">
        <location>
            <begin position="33"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="50"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="260"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT03017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="407" mass="45526" checksum="3994340C1B9FB988" modified="2016-09-07" version="1">MKFSTSGLGAILALSEAVTAATPAEWRSQSIYFLLTDRFARTDSSTTAPCNTEDRRYCGGTWHGIINKLDYIQNMGFSAIWITPVTKQFPEKSGYGEAFHGYWQQDIYNVEPHYGSADDLRALSAALHDRGMYLMVDVVPNHMGYAGPSSSMDYSRFVPFNSKGYFHAYCPITNYDDQANVENCWLGDNTVSLPDLDTGNPEVQNIFNNWISALVSNYSIDGLRIDTVKHVPKPFWRKFNDAAGVYSMGEVYSGDSGYTCHYQNYLDGLVNFPIYYALLEVFKSPGGNIANLYNMINTMKDSCADSTLLGTFAENHDTPRFASYTKDMSLAKNALVFTILADGIPIVYAGQEQHYAGRKDPDNREATWLSGYNTESPLYQLTAKANKIRKKAIADDPNYLTYKVSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7U2</accession>
    <name>A0A179U7U2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="3">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_07809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="3"/>
    <dbReference type="EMBL" id="EQ999981">
        <property type="protein sequence ID" value="OAT02582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02582">
        <property type="protein sequence ID" value="OAT02582"/>
        <property type="gene ID" value="BDCG_07809"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07809"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PTHR46081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="166" mass="18527" checksum="F99A1D583B95BE99" modified="2016-09-07" version="1">MPTISFFSAFSSSTQNKKKMEFPDKRTDKEWQAVLTQEQFRILRNKGTEPPGSGKYNKHSPSSGVYRCAGCNAPLYKASHKFASGCGWPAYFDSIPGAVVRTEDKSFGMDRTEIMCSNCGGHLGHVFKGEGYPTPTDERHCVNSISLRFTEDEGDVREGKKKERGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7X8</accession>
    <name>A0A179U7X8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02622">
        <property type="protein sequence ID" value="OAT02622"/>
        <property type="gene ID" value="BDCG_07878"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07878"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="418" mass="45685" checksum="0984D3F70D2182FB" modified="2016-09-07" version="1">MALLTLTVENDTGITNISSVYPPVDEGRAPLILGLSGCLAVLSILVVVLRCYCRGRIERHFWHDDYLIVFATICSIIVLACFIAESYNGLGRYILFLSSENREYLAKIGYIHGIFDLLGINAVKISFGYFILRTTSGVKIRNSTKGMIVFVLAFTIFTTGMAIFQCVPAAALWNAGIESSSHCLSLKSYVTIGLATDSMNAIIDLILSTLPLPLYYDSNASRYSRVALVGIVALAYIAAIIKIVRRAHVLTTPSSWRIELQIGILAASLPTLNPMFTIIATFISKTFKTPKWPTNNPDTQEHSSACNPIPMGPTPLRRLSRSTLYRHNASSVTTEHSDPEQQHITRYPSSHYKVEVSASRLSGSKNGSRRDAILAGAPSGFPAIMRTTDVFIHTADGNKRGIDEGDVDSASAEIRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U852</accession>
    <name>A0A179U852_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VosA protein, variant 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_08155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02712">
        <property type="protein sequence ID" value="OAT02712"/>
        <property type="gene ID" value="BDCG_08155"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08155"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="PTHR33572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT02712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="404" mass="44342" checksum="06F5D3F187A8C604" modified="2016-09-07" version="1">MSAPTFPEDPVTQRPALQSADFRLTVRQNPERARVAGGKEKERKPVDPPPIIQLKIDETKDPGQNYLQSPFYFMCCTLYNATEDTPATTAQSTALAGTLVSSLHRLKDTDNMEGGFFVFGDLSVKIEGEFRLKFNLFEMREVKRCGGTRDEVVYIKSILSKPFTVSPPKNFPGMAESTWLSRSFADQGVKLRIRKEARTLLKRPMPRAEPEYPAPLAQPRSPERPGASSQQIGAAYQPSRDYPFYNGPEAKRSRSSVDMSGRGLYEGDARYQYQPHATNPYQNQAYQQGMMQGYTTAGTGVSDYPIRQAPQGSTPTPFGFADESMGSIRSPGAGGYMGQPRYQSYSGAQMPYNLSSSAQMSQMGESTPGRTGQAANMGGIVSGQSFSQPAGHMQSPSQVPPAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U861</accession>
    <name>A0A179U861_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF7 family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02722">
        <property type="protein sequence ID" value="OAT02722"/>
        <property type="gene ID" value="BDCG_08168"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08168"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="PTHR22761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="166" mass="18862" checksum="669CF18F9076E085" modified="2016-09-07" version="1">MAKMRDGPGKNAMRQKALKVLQRRKQYEAQRDQLSQQSWNMEQAGMMQDNLKNVMTTVDAMKTTTKTLKQQYGKVDIDQIERMQDEMQDLMEIGNEIQESISRAYDVPEDVDEAELDAELEALGEESMFENVLGEDAMPAFLQDEVGPPQFVDEPPEEGKVKEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U983</accession>
    <name>A0A179U983_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Xanthine dehydrogenase HxA, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BDCG_09167</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="13">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03112">
        <property type="protein sequence ID" value="OAT03112"/>
        <property type="gene ID" value="BDCG_09167"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09167"/>
    <dbReference type="OMA" id="PQAMFIA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 13" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="14">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="15">
        <location>
            <begin position="296"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="1336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="100"/>
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        <ligand>
            <name>[2Fe-2S] cluster</name>
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            <label>1</label>
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        <location>
            <position position="139"/>
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            <name>[2Fe-2S] cluster</name>
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            <label>2</label>
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        <location>
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            <name>[2Fe-2S] cluster</name>
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        <location>
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        <ligand>
            <name>[2Fe-2S] cluster</name>
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            <label>2</label>
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        <location>
            <position position="185"/>
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        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="324"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
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        <location>
            <position position="408"/>
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        </ligand>
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        <location>
            <begin position="418"/>
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        <ligand>
            <name>FAD</name>
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        <location>
            <position position="431"/>
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            <name>FAD</name>
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        </ligand>
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        <location>
            <position position="494"/>
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        <ligand>
            <name>FAD</name>
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        </ligand>
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        <location>
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            <name>Mo-molybdopterin</name>
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            <name>Mo</name>
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            <name>Mo</name>
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        </ligandPart>
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        <location>
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            <name>substrate</name>
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            <name>substrate</name>
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            <name>Mo-molybdopterin</name>
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            <name>Mo</name>
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        <location>
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            <name>substrate</name>
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            <position position="1146"/>
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            <name>Mo</name>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAT03112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1405" mass="154813" checksum="25AF6F80F9554306" modified="2016-09-07" version="1">MGLPVPNSEAASIPSDEALQALVKSTYTTSVLQFYLNGAKVELRNPNPHWTLLDFIRSRRGLKGTKLGCGEGGCGACTVVLQVRDAKNLRRIKHLSVNACLFPLVGVVGKHVITVEGLGSVDKPHPLQERMGKLHGSQCGFCTPGIVMSLYSIIRNAYDPETGKFSLSENDIEMKGHLDGNLCRCTGYKPILQAARTFIVEDLKGQLVEGKNSLPVDAEKDTEHEAATYLQGQFDKASKSSSGSCGRPGGCCRDKPKITLPAYKKEPQIELAEYTPSAELIYPPALSKFVDQPLCYGDEKKIWLRPTNLQQLVDIMATFPSATIVSGASEIQVEIRFKGSEFAVSVFVSDIEEMNTISIPADLSKAKELVIGGNAPLTDIENLCYDLSSKLGRRGSVFSAMAKVLRYFAGRQIRNVASLAGNIATASPISDMNPVLLAINATVVAKTAEKEHSIPMVTMFRGYRKTALPQGGIITQIRVPIPPADVREVTKSYKQAKRKDDDIAIVTAGFRVRFDEGDTVKDVSLAYGGMAPMTVLAPKTIRYLIGKKWSVAETLDGALQTLLEDFPLPYDVPGGMAAYRRTLALSLFFRFWHEVNADFELAEVDQALVEEIHRNISIGTRDNYNPHEQRVVGKQIPHLSGLKHATGEAEYVDDMPYQENELYGALVLSERAHAKIISVDWTTALAPDLAVGYVDKHSVDPEMNFWGSIVKDEPFFALDEVHSHGQPIGMVYAETALKAQAAARAVKVVYEDLPAILTIDEAIEAKSFFKHGKELRKGAPPEKMAEVFAKCDRIFEGTIRCGGQEHFYLETNAALVVPHAEDGTMDVWSSTQNTMETQEFVSRVTGVPSNRINARVKRMGGAFGGKESRSVQLAAILAIAAKKERRPMRAMLNRDEDMMTSGQRNPIMCRYKIGVMNDGKLVAIDADCYGNAGWSLDMSGAVMDRCCTHLDNCYYFPNAHIRGWVCKTNTVTNTAFRGFGGPQAMFITESFMYTIAEGLNMPVDELRWKNLYEQGQRTPFHQVIDEDWHVPMLLEQVREEAKYDERKAQIAKFNARNKWKKRGICLVPTKFGLSFATAIHLNQAGASVKMYADGSILLSHGGTEMGQGLYTKMCQVAAQELNAPIDSIYTQDTATYQIANASPTAASSGSDLNGMAVKNACDQLNERLKPYWEKFGRDAPLSQIAHAAYRDRVNLVATGFWKMPKIGHKWGNYNPDTVKPMYYYFTQGVACTEVELDVLTGDHTVLRTDIKMDVGRSINPAIDYGQVEGAFVQGQGLYSIEESLWHSKSGHLATRGPGTYKIPGFSDIPQEFNVSFLQGVSWKHLRSIQSSKGVGEPPLFLGATVLFALRDALLSARKDHGVKEKLVLDSPATAEKLRLAVGDKLVRMSNVVKGEGQKPFFVAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>C5G7Q2</accession>
    <name>C5G7Q2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 11">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_16249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 11"/>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="EEQ84203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626838.1"/>
    <dbReference type="EnsemblFungi" id="EEQ84203">
        <property type="protein sequence ID" value="EEQ84203"/>
        <property type="gene ID" value="BDCG_16249"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16249"/>
    <dbReference type="eggNOG" id="KOG0803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000471_0_0_1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="PTHR12389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1573"/>
            <end position="1619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ84203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1625" mass="180613" checksum="70C7DE134F0FA913" modified="2009-07-28" version="1">MSKKFKSQASSSRAAFGGFGNSAGAFGKFSTDSMTQGGASSSLSYIAEPPDLSRISQPQLVVSFKNLLKKDTTTKTKALEDLQDFLCAQDTRSESLEDGLIEAWIKIYPRMSIDISRRVRQLAHVLQGRFVSLSGRRIAPYISRVVGAWLAGLYDSDKLVFRAAQESVVRAFPTEEKRQSLWKIYRLSIFEFVIDAVLEQTPQTLSDKRTVRPDEAEAKHARVAGTALQLLKQLLAKSSTTQLDKDSDFISTLITSKSLWSFSCHEDPFVRRSTYDLLRTLLSIKSNLIEWKTISTCFLSKALPTSQLGSALDFSNVLLTLTKERPQLWTSDYSGKVSATKRLYQYIRKGSEGADAAYWENLQLLLKSIPFGILITQPVSDDSTVQDANRLMDTIHDSVLSREEQGANLGAAWSCFVDTGFWISSFISDKVARHKFLQNQISPILEQYILGHPDNGRWSLNGKFAPELCAKTFVVMAEHTGAEAVQSLWTSLSDSLIETIRLSSPEKAIGFKESQDSICAQAKRFFELEGQVLAQVAQNSGLAFVSNIFQVAGTPLLQASVELLRSRNGKPYGAASMIDEAIARTPGIAAQVEGLEMFLSEDITQLLFSPSADRLISILFGSRGKKGFQCGLKSSIDTFLETDLGSSALPGLQKLFSCVTLSDAEAHPKLELLIMKDLDRALHNTREAWIEIITLIKNGALRNGIIHRILNSLVDNLSSEKNIREVLYGLFQIALGCPEIIRGFVNSPDGSRMLSKILYISETSTDEVSQLADSLQIHIRDIIKGESGTRSSIEIIQQNFSNVGIESLSIDALVGIAEEVLAKTSVEDKPRILSRLLPTQDHWGQALGPFLRKPLKASAAITETLAGAVFLADRSSPEGLSRELDSVNRDPYHFSSAFRLTFYATKVLSSISLEFIEQDAREILFFYLPLATQLVNDDVSQEGSKGLLDLDIPDIRDECAELVSEARLIIKDWLQSASPITDQEKSAPNIFDFWEEQFESLQGTSPSSYNVAETFAKVIGERDSPGTARSGESCLKRAKQLDGPSNPFVLPSVVAAFRDFIAASPSGVRLCNELISDCSVFKVENGSEGLRKIVTLNLLICGESNITQNVPKPRLVFLVKHLVDCLQSQSPPQGLVSEILKLLVNILPLIREIYGSHWSNIFEFLHNLWGDMAISDESLPALHSSLRLFACLKSLATSDSNDDLVDIWTTSQKTHSPALIGLLAEFDSSLSYDQPLQITANILSRQIVGLPIDHVEDINDLFSILSAPSRDIQRATYDILHRAIPKLQEAVTLDVALSDAVARLPDELISLLLEVPTINIISQAKFDDHVWIGLRCYLLSWKTVFDHFNNASLPVQESYVSNIKENDCLNPLLEFMFDFLQHQHGKLVDASKFDIRSFNLDESDPPQKETQCMLVHLYYLCLKYLPNLIKVWWIDSKKRVKGQVEAWTEKYISPLIIEDSLQSVNEWFSAQNFAGEDQPLQIKVSHRTAEIIASVDVDEDSPPTSVAISLPSTYPLQQASVEGRARVAVDEKKWRSWLLTIQGVIMFSNGNLVDGLLAFRRNVQGALKGQSECAICYSVISANMQTPNKRCATCKNTFHSDCLFRWFKSSNASSCPLCRNNFPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C5G7X4</accession>
    <name>C5G7X4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="EEQ84534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ84534">
        <property type="protein sequence ID" value="EEQ84534"/>
        <property type="gene ID" value="BDCG_01339"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01339"/>
    <dbReference type="eggNOG" id="ENOG502S93S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006885_0_0_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ84534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="966" mass="104807" checksum="77EEC9632AF2681D" modified="2009-07-28" version="1">MPIKLPKGFARRKSSGNALEALDETPQPSFRVFERPGAARKSLDGSTTLNSSTSNSSHNKRLSEDPYANNIFANIDHPSPVDNRSASSAKFSSSSTLPSSTDIPIQDVPPPPVHDSSFFSFRSAGRTFSFGTKSSSSKSLQRLEATTPRSRGTATARERAPTTSTTSTATPHRLPDTELDMGDSLSFGNMFDGFDKEKEVQKEPLSPSPLGRGSASALPPLPTNDTQNHPTPLRIVPSKDVEPSPRTNESQNSRDGLMSREDDDIISRPPASRVRTSVQPNTNGSLSPTYNTGSTSRFYRNTVQLDRNAAVEDEDAKIVKNAVSAHRRMTAEFSPDGDFPDPLPFSENRLQQRNNVKQITRRPVLQDEESHLAAALAAEASLAERYEENANNSERQLPTKVMTPAQFERYRQQKEMTRKNSNASDTHHSDDDSDHYDEEEEDEVEKAREAAKQRKKQEAHLSVYRQQMMKVTGETIKPLDSDQNGVDKARAASLNNLNRSSFLAPEPTTNGKVSDGEDDDDIPLAILAAHGFPNKTRPPGHLTPSISNPNLRASMLSFAQGPPSVAAEPTAGTQTGRTSLPVFARNLPRDPYNIGAGLVNPSHRESLAMGGGTPSVYGAPPGFPPGGLVGVIANEERAKAMRRGSPNAVRPYDAPPGSLLGMNLNGQHNNTMPLPQQQQFLNVPGAPPGQPPGFGQPDQMSQMTQMMQTQIQWMQSMMQMQGMQMPLNMGLGSHNSTPPNGPSMARPISMLSNLNFNQPQPQGPPQVDHRTLSLLDPKWNNRQSSFLPQQHPHLGPGPGPGYTPSVAPSERSNVGTASRYRPVSTMQQPPQDNAMARSSTFTASTLRPWADAESRKMSLTSNIGGNGMGMQQPYHLPRVATEGSNVVGGLRPVSGLRASTNASVNGGQGGKDEDHHDDDDDEEEEAAWAEMMKNREKKKSGWRFKKTGSSGLGLGDLFPGSGPNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>C5GEL2</accession>
    <name>C5GEL2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJ-1/PfpI family protein, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02731</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="EEQ87611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ87611">
        <property type="protein sequence ID" value="EEQ87611"/>
        <property type="gene ID" value="BDCG_02731"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00417">
        <property type="protein sequence ID" value="OAT00417"/>
        <property type="gene ID" value="BDCG_02731"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02731"/>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="16"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ87611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="253" mass="27638" checksum="7F39732CBB1B2FF8" modified="2009-07-28" version="1">MAANASVETSAPVHYAVLLFPGFQALDAFGPLDILNIVALEQEIQLSIIGPTMDPVSTKSPIPNFYTTTSTSHQSVVPTHTYDAPPENIDVMIVPGGFGTRHETIKPTVQFLIERYPRIRYLLTVCTGSYVAAQAGILDGKKATTNKIRFDLVAAKAPHVNWVRQARWVVDGNIWTSSGVSAGMDEMLAFVQEVYGRKLAVKVATILEYNWHEDSTTDPFANSPLVEMYGAGAADWYDFRAATAIGKDRASSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>C5GH13</accession>
    <name>C5GH13_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BDCG_03528</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">ER-3</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="EEQ88408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="85"/>
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        <ligand>
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        <source>
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        <source>
            <dbReference type="EMBL" id="EEQ88408.1"/>
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    <sequence length="378" mass="41505" checksum="1E10296644D59E04" modified="2009-07-28" version="1">MASIRVSPAGARSFLRLFTPITQTRAATSISPAAASTSTVLQDAIAAEAPRINWTRDEIRQIYETPLHQLTHAAATVHRRFHDPSAIQLCTLMNIKVGGCSEDCSYCSQSSRYDTGLKATKMSSVDAVLEAARIAKENGSTRFCLGAAWRDMRGRKSSLRNVKQMISGVRKLDMEVCVTLGMIDGEQAKELKEAGLTAYNHNVDTSREFYPSIISTRTYDERLQTLSHVRDAGINVCSGGILGLGEEDSDRVGLLHTAATLPAHPESFPVNALVPIKGTPLGDRKPIEFDKLLRTVATARIILPKTTVRLSAGRINMTEEQQVACFMAGANSVFTGEKMLTTDCSGWEEDKKMFEKWGFYPMEGFQRGEFRGDTTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>C5GPF8</accession>
    <name>C5GPF8_AJEDR</name>
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        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDCG_06467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
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        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ER-3 / ATCC MYA-2586</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="C:transcription factor TFIIH holo complex"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cdk-activating_kinase_MAT1_cen"/>
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        <property type="entry name" value="MAT1/Tfb3"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ91347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="379" mass="42592" checksum="597F8E16FE5794B0" modified="2009-07-28" version="1">MSFQSNGTRNRGEEDEVCPVCKSSRYLNPDMRFLINPECYHKMCESCVDRIFSSGPAPCPVAGCHKTLRKNRFRKQTFEDIGVEREVDIRKRVMQILNRREDEFDSKLAYDNFLEQREDIITNLVSGIDVVKTEAQLSQYAAANAKSIRRNQTLESQESAAFLKNQSLEQEQIRLRREAARQDYDNERRALLSGREDILTRLATGSVEEAEAIAKDGRQSMLKKSSARRSEEDRLKRKQAALLVDSKRAQALADAADKGTAPAFDSDLVKGLRRIQTPEPEKPYDPFGGIRLDGRDYYQLQGHYPSTYLDPIKDNVQMLAGGYNLGEYYARSLLEAFAGLGCFIDEEIAARNAATNPSPTGLAASAAASTPIPVDEEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>C5GQC7</accession>
    <name>C5GQC7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic ring-opening dioxygenase LigB subunit, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_06773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999979">
        <property type="protein sequence ID" value="EEQ91653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ91653">
        <property type="protein sequence ID" value="EEQ91653"/>
        <property type="gene ID" value="BDCG_06773"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06773"/>
    <dbReference type="HOGENOM" id="CLU_046582_1_0_1"/>
    <dbReference type="OMA" id="PEGSMSW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EEQ91653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="258" mass="28991" checksum="39E3A63280C796E5" modified="2009-07-28" version="1">MYDHDHPAHRKLQEIGREITSKVKPRAVVVFSAHWQALRDTVEVNNAEITELIYDFYGFPSHYYEEKFPNVGSREIAQKVIDAIRGAGMKAEGVKRGLDHGVWASFKCAFNTDQNPLNVPIVQVSLFKTEDPIQHYRLGQAVAKLREENIQIIVSGMAVHNLRDLRLTYGDSKPMPYTTSFDEALKDAVTTPPAQREKALVDLLKRADARQAHPTFDHLLPIHVGAGAAGEDVGKRLWTLEEGSMSWAQFRFGEVGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5GV25</accession>
    <name>C5GV25_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vesicle transport through interaction with t-SNAREs 1, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDCG_08207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="EEQ84938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626352.1"/>
    <dbReference type="EnsemblFungi" id="EEQ84938">
        <property type="protein sequence ID" value="EEQ84938"/>
        <property type="gene ID" value="BDCG_08207"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08207"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
    <dbReference type="OMA" id="RGRVESH"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="SSF47661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EEQ84938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="203" mass="23372" checksum="0515F18E84A4CA57" modified="2009-07-28" version="1">MARPLETDSGSELFSSYEAELKLVQADLNQKLDQIAESQGEERKLAIKQAERALEEATELIDQMRIEKENIPSATRSKVNARFRNFVTDIDDVKRQLKSLSDDRRALFGDRYTDEPNGINDHHLEQRQQLLSGTERLERSSARLRDSQRVAQETEDIGRNTLADLYVQRQTIEHTRAGLLESEGYVDRSVKTLRGMARWLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>C5GV31</accession>
    <name>C5GV31_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_08213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="EEQ84944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626359.1"/>
    <dbReference type="EnsemblFungi" id="EEQ84944">
        <property type="protein sequence ID" value="EEQ84944"/>
        <property type="gene ID" value="BDCG_08213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08213"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039566_1_1_1"/>
    <dbReference type="OMA" id="GLQTYFD"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="PTHR10880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="SSF54160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="12">
        <location>
            <begin position="138"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EEQ84944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="331" mass="38505" checksum="1AAE5E3435F533AB" modified="2009-07-28" version="1">MAPANHPIYHKDEKVFCFHHEILYEAKILEVRLTDPDDRKSPYEYRVHYKGWKNTWDDWVLQDRLRKATEENRELAATLRRDVEASMRQRTKQSSAKRRRGSDMSSNRNSEERHSSTPARGTKRSRDAEIEKEEHFNARPSIRIVMPDTLKALLVDDWENITKNMQLVPLPAKVPVNKILDTYFEEEKVKRTSQAQVDVLEEVLSGVREYFDKCLGRLLLYSFEREQYHILQKKWESAAEGFVDKGPCDVYGAEHLARLFASLPELLAQTNLGQESTNRLREELSKLAIWLSRNSEKMFATKYKSPGNEYIDKAKGISNPDAPGTATSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>C5GW63</accession>
    <name>C5GW63_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_08489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999983">
        <property type="protein sequence ID" value="EEQ85220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="EEQ85220">
        <property type="protein sequence ID" value="EEQ85220"/>
        <property type="gene ID" value="BDCG_08489"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08489"/>
    <dbReference type="eggNOG" id="ENOG502S0WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063954_0_0_1"/>
    <dbReference type="OMA" id="EICHAHP"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="DUF5519"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="DUF5519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EEQ85220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="323" mass="35993" checksum="7A765026E2EA0B0A" modified="2009-07-28" version="1">MSTTLSWQDPPLASSIPTITLFTLVALCLATFARKVRKGYHDFLALGPGGTPSTPVGYLRICVLRIFTLRNPLNPPHIPSYIHPQSGILNDLPKRIGSRPEVVGIAPQRQMTDRGPKAIYAALTATIKELSLRHPDSLFLGVSRFEKHNTGLFSLPRCQSHLTCNGEICHSHAYDGSMHLTLHPADVKTIIEKGWGERHPLARESWWWRFRFVPPTFVLIYSPRTVEELRCVTQIIYAASWWISGIDLRKFDPNNGITPATVHEQEYQQRQKQQQESSEAESDGVRTDQVWSSYSTELNANASQASASGSATCDMPGFPMGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C5GWV7</accession>
    <name>C5GWV7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine phosphoribosyltransferase 1, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="EEQ85440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002620357.1"/>
    <dbReference type="EnsemblFungi" id="EEQ85440">
        <property type="protein sequence ID" value="EEQ85440"/>
        <property type="gene ID" value="BDCG_08709"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08709"/>
    <dbReference type="eggNOG" id="ENOG502RBZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="OMA" id="TYNDVHN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ85440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="204" mass="22892" checksum="9E3E5F28CEB990A0" modified="2009-07-28" version="1">MVEKVYVTYNQVHKLCQASADRILNDFRPNLMVAIGGGGYIPARMLRSFLKQPGGGNIPIQAIGLSLYENLGKDDQIEELGTKVTRTQWLDLSSLEMANLIGKNVLIVDEVDDTRTTLEYAVRELQKDVQLAQQQLGREGEKTTFSVFVLHNKNKDKKGKLPTDMMESGRYLAAVTTGDVWICYPWEAKDIDEHDQLAAQHPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TV06</accession>
    <name>A0A179TV06_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CMGC/MAPK/P38 protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002626742.1"/>
    <dbReference type="EnsemblFungi" id="OAS99713">
        <property type="protein sequence ID" value="OAS99713"/>
        <property type="gene ID" value="BDCG_01106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01106"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="273" mass="31502" checksum="F2B3359EE366B725" modified="2016-09-07" version="1">MSPEDNIYLITEHQDASLEQLILSQPLGETHYTKVFLYQILRGLKYIHSANVVHCNLKPSNILIGHNCDLRITDFDHARIQGTKVTEPFSEIQCFRTPELLLGECTYEFAIDMWSVGYIFARMINRELFSLEDWKVNSLHAIGYPPRSMMSGIDDANISENLEPLLNTRCKPLRCYINTTDLEAMGLAEHLLAFDPKARYQANQALLHKYVSFYHDPDDEPVSEQRWSVSDTDYVNLPVDTWKTLISLSEILDHHNKQLSSEVSSKYVMVEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVQ7</accession>
    <name>A0A179TVQ7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99983">
        <property type="protein sequence ID" value="OAS99983"/>
        <property type="gene ID" value="BDCG_01706"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99984">
        <property type="protein sequence ID" value="OAS99984"/>
        <property type="gene ID" value="BDCG_01706"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01706"/>
    <dbReference type="OMA" id="KVIREMF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="283" mass="31604" checksum="55080657543D50ED" modified="2016-09-07" version="1">MASEGHSPCEEYSTGEEHPTGIAPAWSELSYQNRVQDINGYMESEWVSPHSNFQASANPFATTAHTNGSMPTPISLCGTPFLEPRESPSQSHQDLQYRDIVDSPTHGLGISGPTTSNYVQPGIFTYDHPHRDTLDSHFSPESQGGGFGLRPLNGTTQPSTLVTQPNSAKCHVNIAPNPAGLLKIQRDRKRSQGVEVSQRRRSRSARRNSGQRSRPSQMDRENELVRLLRTERNLSWREIVKIVNAQFGTNYSASCLQMRMTRMKHRAMQWPEEDVSPSTSTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TVR6</accession>
    <name>A0A179TVR6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MYB DNA-binding domain-containing protein, variant 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">MYB DNA-binding domain-containing protein, variant 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01712</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ER-3</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99993">
        <property type="protein sequence ID" value="OAS99993"/>
        <property type="gene ID" value="BDCG_01712"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99994">
        <property type="protein sequence ID" value="OAS99994"/>
        <property type="gene ID" value="BDCG_01712"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01712"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAS99994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="201" mass="22529" checksum="8F076ADFA4E7BAEF" modified="2016-09-07" version="1">MNWPVFVSRPPLPNMSSPPTSKRIKTTVASNTPTHPLNQQQQQQPHPFTGPGPFESASMVPISTPVPAPAPAAPNPRKRREGNTTTTSITGAPTAPEPTVKKKGRTNTPWTAEEEQRLKTMRDAGNTWSEIAKTFPLRTEGSVKKHWYKDMHYAEFTEEESITLRDAIKEYESSKWKVIGQKIGKPAKACEQYAKEHFKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TW27</accession>
    <name>A0A179TW27_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RINT-1 family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_01153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99739">
        <property type="protein sequence ID" value="OAS99739"/>
        <property type="gene ID" value="BDCG_01153"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01153"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="PTHR13520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="601" mass="68374" checksum="D0BB9BEEED89A648" modified="2016-09-07" version="1">MSGRMRLNYYWSYKRQNSALVTSPESARRWEPPVLLPLVVMARPLELRFKYHFSGDRSTNRLDKPEYFLSHVIDLINTHSDFFAIYLQPILDRRAELVDYNLRWSYSDAVSSFITSLFPMLRQKMSSILPRIADHPQLLSHFIHELMSFDTEIRDVWDYSQDRYSSETWKGLTWEALVKQGWFNHWLKVEKDFALSRYQDIIESADSGEIDYYCVEPSATKPTKAAIRVNDLLETITERYRPLSSFSQKLRFLIDIQITIFDQFHERLRSGLEAYLAMTSTIGRTVQGSTGADANLEGVAGLERLCRVYGSAEYLERKMQDWSDDVFFLELWSELQERIKQNSRTGRPVAGPMSVSDVAARTSSAVANHNEDGGNPTEGALFDETASAYRGLKTRSESIIISVLISSAQSALRGYTRISTWSSLSPPTNPSGQFSHPSIELATILRELPTEISFLHRLLAMAPLQRITRQLLLSIQSYIWDNVLMRNTFSTTGASQFAADVDNICKVVDVATEDGMGSRNVMRKLEDGLLLLNLKIKPTQKDHGASTGAGDKTPNLSLWEAEKRIFASNESARSLLAELNIETLTEAEARAVLERRVEVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TW29</accession>
    <name>A0A179TW29_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BDCG_00053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99268">
        <property type="protein sequence ID" value="OAS99268"/>
        <property type="gene ID" value="BDCG_00053"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00053"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CLTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LisH" evidence="4">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAS99268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="264" mass="29450" checksum="0D1F9517F8BB7CC9" modified="2016-09-07" version="1">MSPTPSTTTPTWHHFEKKVEDVKPSKTDINFLVMDYLVANGYPSAAQKFAIEANIQPKPDVESIQERVDIRNAIHSGDIQSAIEKLNELNPQILDSDPSLHFSLLRLQLVELIRTSTSTPNGDITPALDFATSHLAPRAPTNPQFLEDLERTLSLLIFPSDNLAPSLAALLDPELRKNIANHVNEAILHSQGARREARLRNLVKLRSWAEQKAREAKKDLPEKIDIGLEQDRNDSNDSSQSENQNGSTDDAIMHEQGEVDPMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TW38</accession>
    <name>A0A179TW38_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00124">
        <property type="protein sequence ID" value="OAT00124"/>
        <property type="gene ID" value="BDCG_01938"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01938"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="401" mass="46673" checksum="F735D52D67459758" modified="2016-09-07" version="1">MVRSIIRISPYELHIDDPDYYHVLYSYSSPRDKYQYYLEPFGFPLSAFGTESHHQHRHRRGALNPFFCKRRVAQHEGLVHHLVNKLCGHLEQFRITGKTVPLSLGYTCLATDLIVSYVLDERQQWLDAPGWLPHWRRALVSLSEMVMVSRQVIWVLKILKYFPRTLAISMKPGLGLFFELEEGFRRRIKQIQMDRDGENDRQPKCTTSKASKGYSLIDQILDSRLPVEEKAPERILQEVRSTTAAGIETTSNALTVITYYLLDNPDKIQRLRDELSTFEGDWSSKQPAQKLEQLPYLTSVILEGLRLSYGVSTRLQRKSPDQAIHYRDYCIPPGTPVGMTSVLMHHNETIFPDSHKFVPERWLDLDERKRLERYLVSFGKGSRRCVGQRKLNQSDICSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWS3</accession>
    <name>A0A179TWS3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_02556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00364">
        <property type="protein sequence ID" value="OAT00364"/>
        <property type="gene ID" value="BDCG_02556"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02556"/>
    <dbReference type="eggNOG" id="ENOG502RJUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="118" mass="13642" checksum="635594A4F08F769E" modified="2016-09-07" version="1">MVLACQLDSERNLFSDLARIQLILSRKPLPRIGSLTINNECILDINNRLLMLEICHLENENIPIDIQRKTSYSTVDTYIHDLLSVHDNRLRYQPNGASSMKDCIKPDVCIDNDENRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWT3</accession>
    <name>A0A179TWT3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_01555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99912">
        <property type="protein sequence ID" value="OAS99912"/>
        <property type="gene ID" value="BDCG_01555"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01555"/>
    <dbReference type="eggNOG" id="ENOG502RT2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="319" mass="35588" checksum="619010DB38CF2AE5" modified="2016-09-07" version="1">MTAMAHIVGYAGDNGNIPAAQRAAMSEEEKALRSLGSKCFMTGWYTYIGLIWTLKMNMLFFYKRVVNGLWVERFILPAQLIVGATGASILLLLGFTCRPFHKLFQVYPDPGPLCTPQSLAFLIPILIMNVLTDMMIMAIPLPVLAKMRVSLGRRIGIFILFGATIFIMIAACLRVYFVIALKTGPTAAIWSCREDLVAVFIGNAPIIRPLFSRKIWLGGYKNGSKPSGYETGSSVELSGKFASDRSNKRNSRSFYSRDMKPTTVDSDSMERIVDSSKDGDLPAMVIQVRKDVRVDEDVEDNTSVGKVWQQSYRDNFKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWT6</accession>
    <name>A0A179TWT6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_00125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99306">
        <property type="protein sequence ID" value="OAS99306"/>
        <property type="gene ID" value="BDCG_00125"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00125"/>
    <dbReference type="OMA" id="RCELADT"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="559" mass="63081" checksum="83887D5D741557D0" modified="2016-09-07" version="1">MGWTSSSFNIHRVQTSKQPALLEKTLPNWAKYELKQGAEVASEAKRFRRSRSLSKSLKRWWDRWQQMRATVDFDPSVDTDAKGEIELAGESGRKPFFVRKVTIQGWQGYGPVKEMVHLRDESRLSGPSPVDFTGFNEWFHNGQSYQEEISLEILPTPVLKPGRFSRTKEWLTNHRNSSRVSFFSSSLSPSSQQSFFRTPNTPNSASSSRDSHSSELPVDIFCALHELADTSPVNVRQTQTPLQQTRISVASVAPQYSVPEATESDQNGLRCGAQESYTSSKVEPQIYQFSPISSVDGCASPPLKGATDFDNEHSLNEGDPQQLTELSPLVDQPPMYQVTAMTPNTEVLAFHGFQKGDSAEIQLPDPGPIFDLPLQENSIYQSHRQTANYSNNENGGSYLGDGTRDSSFQSSALGNGGDGCGTEGHGNCDESENNSREEDDDGNNRKRKRFKRADPGRTRRQFACVYHKYDPQTYHGDHHRKYLLCSGTSFKFISELTRHLCRVHGEHVCPHCYRTFRNKTLRANHAQNCTVKLRCSQEDKWAALWRERFKGVDMSQSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWT8</accession>
    <name>A0A179TWT8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00326">
        <property type="protein sequence ID" value="OAT00326"/>
        <property type="gene ID" value="BDCG_02432"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02432"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="321" mass="34861" checksum="9920B0E9EE3BAAF1" modified="2016-09-07" version="1">MLPPNFCSQFFRVNFTNARHYSNIFPWGRFLGSDTSDDSGEDEEKGGSATPESSDLDHPGGALEVAQPTNRTDVDKGLSTAPQSTDPDHPVGMQKVDTEPDAEKVLPVAPQPTDPNHPVEAPEVTSPTTGTDVEESLQPTQGVGHDESAKELESTAPADVDEPIAELEPTQAADEVTHTNQLEPSNTAHTNDPNAMSEKEQGNESKDNDSRKGTGSLETKEVHPVDPFISTWEVQQWVAVAPLSPIDRSQEQSNNQSADSKTSTPQAAKTQPQYPCEKPSQQPITPGKEASTAAYHSTPKKFKPGLWSRFWKGVSRLYHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TWT9</accession>
    <name>A0A179TWT9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00285">
        <property type="protein sequence ID" value="OAT00285"/>
        <property type="gene ID" value="BDCG_02368"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02368"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="510" mass="57046" checksum="26C5EB2037990EE4" modified="2016-09-07" version="1">MRSKVGTAEAILDSQTTTTAPRRLGKDRPRSKSATGIRPDVGNQSPVRNVHVQEPSATRPPVPPHRSAAGKDNAFIPKSHAEKEPPRYVYRGALDDSPEMELTHQVHRGITQAGMGASYAERARRAVAPEIDIEGMYQELMYYRRATQHAFRESEYYKRVAGSLHKELEDCKKDLWEAQDEKKALGQQILDLGTVAEGVTDEVLRRIFQNTIGSAVEAHSKVFGKPTGDDAERLGRLLSPECTKLLQQFGRKYYHSLLASALFKETADAVGKKYVVGATSGILRLTRELGVDLDPRSSLTFLQVLEEILHLPSMGVPQREINVWRSSFVKLLQYLPEVKELANSSGAKASAESELLELVDEVWAKLEPHIPLGDKGRRGLQKLLKLQANLRVKTSLSLASYELKFHEPGTQFNVSTMRIVDITEGECEDDELHRLDSESCGRKLVVGYCFFPALYKWGNDRGFDNEKGHVVARATVLPVYEDDPFLQQQIFDDANQPPKLDDIPMANSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX40</accession>
    <name>A0A179TX40_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_16629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00474">
        <property type="protein sequence ID" value="OAT00474"/>
        <property type="gene ID" value="BDCG_16629"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_16629"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="60" mass="6882" checksum="6C76CE4D108B0008" modified="2016-09-07" version="1">MDVDDNDGGSYHSDSTATDPADYNKQEYYMKMLNSGNKSLLQYNEYTDNSPKLLSHIEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX48</accession>
    <name>A0A179TX48_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_02615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00385">
        <property type="protein sequence ID" value="OAT00385"/>
        <property type="gene ID" value="BDCG_02615"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02615"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="268" mass="31215" checksum="3729A61904F0AE15" modified="2016-09-07" version="1">MKNKGRRGREFNSTKPSRIFFRRRGKKFGGAMRCGAVRVVQGCLGGERFLQWGNRDHQIRLDSLEFGAREWLVGNAGFSANGWKGNVVPRERERECRMRGARCEVRAAKKSTLETSDQWYEEYTNGDGRQAKRGGVVAVGRGQNGSEWALRRAERRTRESWLAMERRWKTRTRTRTRTGMTAAGRLSCLTQTRERQGEDNNNNNNSGKGERMEMEMEERRREEEEEEEEKKKKKKKGLEADTQKGGRKQERRGEGRNQPRDTHKESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX50</accession>
    <name>A0A179TX50_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_01815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00033">
        <property type="protein sequence ID" value="OAT00033"/>
        <property type="gene ID" value="BDCG_01815"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01815"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="PTHR35020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT00033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="184" mass="20923" checksum="68209ADFE619971E" modified="2016-09-07" version="1">MMPHLNDPAAPAAVAETADDARITPLLTTTTTELVDEETAITTPAEPLPYWLVNVPRSQWPPECPEYLRDLPQKSIKCLSTPDAQYERQSWALVKEIVGSNQIHLLQRVPSELRRYLEYTAKIKDKYGSVLNFVVQKRLGWVDDLKPRGTRPFDHPGLFFSPFDLAERDSLLFLASSYIGRLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TX53</accession>
    <name>A0A179TX53_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_00908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cell membrane</location>
            <topology evidence="1 3">Lipid-anchor</topology>
            <topology evidence="1 3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99617">
        <property type="protein sequence ID" value="OAS99617"/>
        <property type="gene ID" value="BDCG_00908"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00908"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="PTHR31468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="204" mass="22761" checksum="E9EE33F3943672A3" modified="2016-09-07" version="1">MKELGANAIRVYHVDPNGDPDECMKALADAGIYLFVDLDDFPTQIEEQSPIWSQKQVDAFKLTLDELQKYGNTAGVFVGSEVFTVANDSAASPYFLAAARDIGAYRDSKDYRRIPVGYSAADIAELCPMLRNYLVCREDESERLDSFASTRTNGAVNQHLKSPAMPTCKTKQRDTRFRFSFQKLAATRSDHEISTTSIPSLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXU4</accession>
    <name>A0A179TXU4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_01490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAS99878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99878">
        <property type="protein sequence ID" value="OAS99878"/>
        <property type="gene ID" value="BDCG_01490"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01490"/>
    <dbReference type="OMA" id="AYWCEYH"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="PTHR46009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1" evidence="11">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1_C" evidence="12">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAS99878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="415" mass="44808" checksum="6A466BD9D2E8A7F2" modified="2016-09-07" version="1">MTANIPAPLKAADITRFVTRASQLDKAKPVISYWCNYWIVNQILSKGLHNSDSECLKYTTDLMDKLEKFKSEHADDDTVTDDAAGQAYVEQFGLETFQRADNAVRANKASLQTADTFQAAATFLELSQIWGPIDQEKAAKIKFAKYHALRIAKAIKAGEDPNLSNPSMEEEGNLDDAPALDPNDPEVQALGGTPSQLAPEVKLRQPSVEDVPDEFDKEERRLAKQSILNESLHPSRASSLPPPRRAESGNVTAASSTGLPSPPTYSAAPSDFPSPASSSQELSDPGPGPGQFSERRTSLSTFQSFPAPTTQPAEPPKTTDLQGPAGIHTPPPTTLEGWTRPTPPNTVPPTSIQPPKTMHSISSYSSPPPNQGVVDEDSIAEAQKHARWAVSALNFDDVPTAIKELRNALNKLGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXU7</accession>
    <name>A0A179TXU7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_02367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00283">
        <property type="protein sequence ID" value="OAT00283"/>
        <property type="gene ID" value="BDCG_02367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02367"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT00283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="433" mass="48610" checksum="5A714CD37A5911CF" modified="2016-09-07" version="1">MKDCQLDWIITVPAVWSDLAKKKTRTAAMRAGMGDTTSLQMTSEPEAAAVYALKALDPHHIKVGESVVICDAGGGTVDLITYKMKSVDYPYEVEETAIGGGSQCGSTFLNRKFEEVLMRKLNGKPISKNAKAMAMSHFEKETKRNFGTEDEDEDEEDIEFQIPIPGVEDDPSVGICAGFLEMTYTEMKDVFRPVIEEVLALLNDQIKAASKQGPISAVILVGGFGESTYLYRQIKQAVSPIPILQPPNGWTAIVRGAVMKGKSQLSATPTWNVRSRYCRGNYGLVLWMPWKQGMPTDKKVWDKYEGLYKHSECMQWCIKRGDKVQENTPKSFPLYRAVPLDDPLVFSSSIYYSPLDGSSAPVYLNQDCREHCVLNYNLSSIPRSKFKRKQGNHGEDYYEVEYSIGVTYFSAEMRFELVCQGEKYGSVTAKWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXV8</accession>
    <name>A0A179TXV8_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">BDCG_03310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00655">
        <property type="protein sequence ID" value="OAT00655"/>
        <property type="gene ID" value="BDCG_03310"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03310"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="PTHR10640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="8">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAT00655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="237" mass="26506" checksum="BB8F0E7673AC7AA5" modified="2016-09-07" version="1">MSAIKDESNNDHLVQSHDPEHPANLIPALCRNFYGHGWVTGTGGGASIKRDNHIFIAPSGVQKELIQPHNIFVLQYPTPKYPPSARQYIRKPLELKPSACTPLFLAAFDRGAGCCIHTHSQWAVLVTLLVEREKGLEGCFEISNIEQIKGIPKGKGKGMMGFFDTLKIPIIENTAFEEDLTSSLEEAMEKYPDTYAVLVRRHDMSGETMSQKPRRSARAWIIFSSWRSKCISLVCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TXW0</accession>
    <name>A0A179TXW0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Adenosinetriphosphatase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BDCG_00454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002625048.1"/>
    <dbReference type="EnsemblFungi" id="OAS99450">
        <property type="protein sequence ID" value="OAS99450"/>
        <property type="gene ID" value="BDCG_00454"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00454"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHDWQFF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="SSF101224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="208"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="504"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="870"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1089"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAS99450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="1129" mass="129181" checksum="7C68383509ED4316" modified="2016-09-07" version="1">MAPSLSHLSGSESPAQADTPMADANGYPSNTMEGTRDEDQSMVDTPDYTDSDTNPNTTASSIAGDIAQQDGRKRRSEAFQLRKSVLGRKHGRLDESKEDDSIRRFRYLLGLTDLFRHFIETNPNPRIKEIMAEIDRQNEAEANSRKGLTRKGGASGERRRRTEQEEDAELLKDEKRGGQAETVFRESPAFVKGGEMRDYQVAGLNWLVSLHENGISGILADEMGLGKTLQTIAFLGYLRHLRGITGPHLITVPKSTLDNWHREFSKWTPDVNVLVLQGAKEDRHKLINERLVDEKFDVCITSYEMVLREKSHLKKFAWEYIIIDEAHRIKNEESSLAQIIRVFHSRNRLLITGTPLQNNLHELWALLNFLLPDVFGDSDAFDQWFSNQEADQDTVVQQLHRVLRPFLLRRVKSDVEKSLLPKKEMNLYVGMSDMQVKWYQKILEKDIDAVNGAQGKRESKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLIDNAGKMVILDKILKRMKNQGSRVLIFSQMSRVLDILEDYCVFREHQYCRIDGSTAHEDRIAAIDEYNRPGSEKFIFLLTTRAGGLGINLTSADIVILYDSDWNPQADLQAMDRAHRIGQTKQVIVFRFVTENAIEEKVLERAAQKLRLDQLVIQQGRAQQQVKNAASKDELLSMIQHGAASVFSTKGPTGALAKGNDISEDDIDEILRKGEERTAELNKKYEKLGIDDLQKFTSDNAYEWNGEDFTNRKKDIGINWINPAKRERKEQSYSMDQYYRQALATGGRTADPKPKVPRAPKQIAVHDWQFFPPKLQELQEKETAYFHKEIGYKAVLPDGPDEELSDREAERELEQQEIDNAVPLTEEEQEQKAALSEEGFGNWNRRDFQQFINGSAKFGRTNYTEIATEVDSKDPDEIKEYAKVFWKRYTEIQDYPKYIRVIEQGEEKMRKMNHQRKMLRKKMEMYRVPLQQLKVNYTVSTTNKKVYTEEEDRFLLVMLDRHGVDGEGLYEKIREEIRESPLFRFDWFFLSRTPVEIGRRCTTLLNTVAKEFEVDGGKIPNGDTGSGKGRGRDRDDDVENEEVEAPAKKKTKNGAVNKQLKAVQSASGSRATSTATSRAGSVSSSAPATSKLKGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY68</accession>
    <name>A0A179TY68_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_02677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00403">
        <property type="protein sequence ID" value="OAT00403"/>
        <property type="gene ID" value="BDCG_02677"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02677"/>
    <dbReference type="OMA" id="IRMFANA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="SSF47370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="721"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="901" mass="97830" checksum="8C1A4877BBE383EE" modified="2016-09-07" version="1">MPSLSSYTPFESLLFFQFLNTLDSQPSNFTPISELLINNSFVRQNATFDKARLTPQALEALYINLVQEELQNREGTPEHGSNGYNSDAVNANLKKRKIQDPSSKHEGASYSTVIPTLVARLYARYKERATREIEDEERKYARIKDEIKKLENAETAKHTPPIIDGPSATPEISKEAAQAQPSSPQPATIAPRVNIERPRDQVLEQVQAVQMPKYAQRGLVEGQATVQQALQIEGKLANAPRSSPQHPQAQQWQQAGPQAIAQNIPPRSLSPNLGNGNASILPSQDHISSRGLQYATSKPGQPGINTSTIPHAGTGRVPGQVLTPVTSATSQASPMSLQTTPTATSAQQQQQQQQQQQQQQPQRIMATFQPVQYSPPQAQMTQTPPNTNYQKQWSPQPVPSTTYGQPSPYANVPYSNSQLTGKSHLPLGPHSPYVQLEAGKSFQGPSGPSLQPSRPVGLGLPQLQNDARAQTTPHEQHIATPVSTPGSGGLDLCTPSFSAALNRRPPRPSLDTSGSLTPWKKPSPIVISKSPGSPIRPRPEDVSPISEKAPSPTTEIEMPSISTTRPKGQTVHADVDSSPAKNTRQRKSTPALRGRATASPVSSPIRSTRNRSRGARSNVSRDDESITDSGSVTQQKIKREMPSTPAGISDETEVELRASRRLKAPSQAQADEYVSKGKGKRKRGPSEAEDATQPPTRQAAQYVQCTRNFPRTCAPIMNDIASHKYASIFAKPLTERDAPGYKSLIYRPQDIKSIKSAIHQGSKAVAAATEAVNTPSGENTESPGPGPGFGTTPSKSNGLLLRRTAELTPPKGIVNSAQLEMELVRMFANAVMFNPTSEKTFGPSFPMQSDWASREGTQVSDMDEGGIINDTLEMYDDVEKAVSSWRAAERAVDDLGVKRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY71</accession>
    <name>A0A179TY71_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">ER-3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OAT00863"/>
        <property type="gene ID" value="BDCG_03761"/>
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        <property type="gene ID" value="BDCG_03761"/>
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    </dbReference>
    <dbReference type="OMA" id="KSNDAHA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="235" mass="26279" checksum="A1179414ED133709" modified="2016-09-07" version="1">MEEGVEEVAATMNEPGSRKDQRHLKKLCLERDGHRCMATGIIDIDAKISEADTEYGSPTDLCYVVPFSLGRWEKSKDHKIAQIWATLKKLFPQIQLAPEDINDPRNLMTLWSPVHAAFGSFTLSFEPTGEPNQYQILLLSRRRNVIQVHLPASQGGPDGPRLVTLERHGGATIELPSPALLQMRSTLTKIFHASGMAEYIEDLVRDEEEIGCLAPGSTTNLEDLVLSRMLRSRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TY77</accession>
    <name>A0A179TY77_AJEDR</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BDCG_00771</name>
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    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99570">
        <property type="protein sequence ID" value="OAS99570"/>
        <property type="gene ID" value="BDCG_00771"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00771"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAS99570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="815" mass="90216" checksum="9C004531DF7589BF" modified="2016-09-07" version="1">METNNSAAPANTNGQLTSPQLHSDSSSFPTPGKRKRVLSPNQESPKGDGISDPTVTSRRELLDQTLKDLLRVLEKYDSDLGILKIPLPLNYAVEPDPKRAKLSNATNNSQTIECKIEEGQYKSIQEVIDDVETASGLVIERRRESEANANKSDHSRSSTELVNLSRIFRKHLDNFILRSPLQGTALVKAESQELQKTEPRNRDNSRRAYDREDKMVLTLYGNAPRGRHLFSSLQHSIAEQPDSRDQGKPPGAGVRATINEAALPNGITISKVIPFNVKIAESDKAKARTIADVFPARPTLPQLQPPLKPRSSKNSTITWLDPYELTIAANYSPNEKRGYSYLSLPSGDWLHYGYEPSLRPGNRRPKSDTNIGRNLSKPFQHSLDDGNAKFRGLYSSFAPSFDSSGAVVPEDAKEQIWWDKHGQYRLHALLSVGNDMTAEETDSKTTNLQIEPLDESSLEEAVKSFDPEDDNVLIEPQKSADGGNDDKDLEEVLENISDLLRTLNSYRHIRNLGQTHPVPSGIQNDAVATPSDASSPSATEVTVYETLKSSLIAMIATLPPYAVSKLDGDQLAELNVSKKILLESADYPGMMEEDDYSMQQKQIPRASQMPNVARPPSASNMNPSRPSPYQTPPTAPNASLARGYPSNSRTKTPMGHSSHQAYGTRQPSSSIHYAPSNSPQPYNQPRQSSGQRPGYTQPQFSQPAAPQYNQGNNILQQFQRPTQVGIGPYPSQRMPSPAQAPTQPYPRRASQPPYQQRPQDSPYGSPASVPHTASPQRHSSFDTSNNKPHNHHTFQHSVLPKPARRQQDIPTALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYW8</accession>
    <name>A0A179TYW8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar transporter, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_01836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00047">
        <property type="protein sequence ID" value="OAT00047"/>
        <property type="gene ID" value="BDCG_01836"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01836"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="107"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="438" mass="47758" checksum="8C66DA441A110D3A" modified="2016-09-07" version="1">MPFFVNPLKNNDLSSFPGVVVPLAQAQHKNPASPTNSGDGKSDNVAEKGSSSSLSDQQYSGLTLDAIRAEVESDVATSGSDTAYDRKSKVINLAVQDIGMGKYQWQLFVLCGFGWLADNLWLQGVALTLPSLSVEFGIDESYVRFTTCSLFVGLCVGAVVWGTASDMIGRRLAFNLTLLITGVFGLASGGSPTWVGVCSMFACLGLGVGGNLPVDGALFLEFLPFASGNLLTMLSIWWPLGTLVGSMIAWGLIPNFSCDPADLLCTKENNMGWRYLVITLGALTFVMFLCRFFLFHLYESPKFLLSRGRQEEAVATVHAIAYKNGAKTWLTNEILNEIGGHPEQISPDQQKLSNSEIVRRQLSKFSAQRIAPLFATKRMGFTTVLLWFCWGTIGMGYPLFNAFLPQYLGNSGETPVSIGMFRASSHTYTLPQFFKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYX5</accession>
    <name>A0A179TYX5_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BDCG_02294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">ER-3</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="OAT00250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00249">
        <property type="protein sequence ID" value="OAT00249"/>
        <property type="gene ID" value="BDCG_02294"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00250">
        <property type="protein sequence ID" value="OAT00250"/>
        <property type="gene ID" value="BDCG_02294"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02294"/>
    <dbReference type="OMA" id="DIYGQTW"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAT00249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="360" mass="38672" checksum="A63E4A9A1CCA310D" modified="2016-09-07" version="1">MAGTADANNDIPSATMSKLIRSVLDDTFYNIIHDIVAKVHREEKIARMRSAVVLAKKLGEEEASRLQANDLVAPESGSVEPGATAPSSVKQKDHDPVRVETDGATYDSGKVYLKGNPFQVTKEILCPNCRLPRLLYPLSGIGSRPPPDPYKEYCKKHPPIIMPGHDVHGNPFATDKINRKRKQQPQQQTSSNTPASSPPSTPSTPSNSFKHVVAEKISFPTVKCPNCPRYFVVTRVAQHLDRCLGLSGRQTKRNLTPMDNGTNTPAPPPMKPSTLKRALPSGDDDAASGSITKKKKLNTPKKYSGKKPTPPSKLKIGTTPDMAAAMDIPDSTPTSAGGGGDIDAASTTTTTTTVTTTSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYX9</accession>
    <name>A0A179TYX9_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_04335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01114">
        <property type="protein sequence ID" value="OAT01114"/>
        <property type="gene ID" value="BDCG_04335"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04335"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="359" mass="39373" checksum="C62EE5B2BACBF721" modified="2016-09-07" version="1">MQKGDILGHEFCGEIESVGASVKKLKTGDRVVASFQIACGDCRYCKRKLSSQCERTNASQLENSLYGSRTAGIFGYSHLTGGFSGGQAEYVRVPYAETNLLPLPANVPDEKGLYLSDVLSTAWHCVVDTGVREEDVVAIWGAGPIGQMCAEFSFMHGASRVILIDGGAGAWRLDFVKEKLPRVETVDYSTLQSGESVTSVLKQMVGDGQGPDAALECAAGEYAKGWAHYIEIMLGAETDTSEILNEMVTSVRNFGRCGITGVYVGYTNHFNIGSLMQRGVRLIGNGQAPVQKYWEHILSLIESGTLDPLRMISTRVKLEDLDLVYRMYDERKRGIQKVFVQTKFSNEQFPGSPALAEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TYY1</accession>
    <name>A0A179TYY1_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_03324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00663">
        <property type="protein sequence ID" value="OAT00663"/>
        <property type="gene ID" value="BDCG_03324"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03324"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT00663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="126" mass="14077" checksum="D6429B869BEB69DD" modified="2016-09-07" version="1">MSRQMSRQRGSGATEEGGRGARQTRGEWKREERRLGGEERGERREPQWDGGYRGGGTWPADFCGGGTCWYLPPGASSLAGGYQPPSKPALGKAWEDAATRNRQPPMRYLRTEASSFPYAAFRYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ92</accession>
    <name>A0A179TZ92_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin reductase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_00429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99441">
        <property type="protein sequence ID" value="OAS99441"/>
        <property type="gene ID" value="BDCG_00429"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_00429"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAS99441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="294" mass="32752" checksum="98E59CDCDAD0B848" modified="2016-09-07" version="1">MKNGTVLEITPVKYSSDNLPHFKVEIDMGSEGSSSPVTKLARKVILATGMEDVLPDTPGIREAWSQGIYWCPWCDGFEHRDQPIGILGDVTSTLDNIMHIATINHDIMVFTNGTELPASETYGLETYYGITYNYSPIKNITRLQDGGTHFDSRNQSEFDVFTVHFEGGAQPVNRSAFFTAFDSKQCSDLPYKLGLRMVNGKIDNNFRGMGTSMPGVYAVGDCNNDDSTNVEHAMFSGKRAAVEIHILLERENATAMGMTLSKRSQPLSIRELEERIEKEIGNEFESLWRAGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZ99</accession>
    <name>A0A179TZ99_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_03772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00870">
        <property type="protein sequence ID" value="OAT00870"/>
        <property type="gene ID" value="BDCG_03772"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03772"/>
    <dbReference type="OMA" id="YDALWQS"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="166"/>
        </location>
    </feature>
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        <location>
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            <end position="219"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT00870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="431" mass="47065" checksum="4867845DD77F6A34" modified="2016-09-07" version="1">MYNALSGLGGSGQVDPTVAANANVALLAANAATALFVVGPIFSIIGPRSCWLVGGWTYALYSGSLLAFNYIENGPFVIVAGGVLGVGASFLWVAQGAIMTTYVPESQKGRAIALFWIIFNMGGTIGSLASFGLNYNNPEGTVSNSTYIATMAVMAFGWAIGVFICPPSRVELSQLREAEYMIRDRSLPALGKLIFSTIFRVKILCSLPLFFCANVFYSYQQNDVNGKTFNIRSRSLNSALYWMAQMCGGLLMGFLMDLRFMNRRQRAWLGWVVLMLSGLGTWGGGYVFQRWQDERTAVGLVQDIDFTSSDISIGPMFLYIFYGLYDALWQGYCYWLIGSMSNSAAVTAILVGAYKSFQATGGAMAWRVNALKTPSMTQLAMNWGLCVGALIIAIPTVSSVTLTNIVRPETSQEDKRSMKLEEWEGDMKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179TZZ3</accession>
    <name>A0A179TZZ3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal specific transcription factor domain-containing protein, variant 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fungal specific transcription factor domain-containing protein, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_01105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2009-02" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Blastomyces dermatitidis strain ER-3.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <consortium name="Broad Institute Microbial Sequencing Center."/>
                <person name="Champion M."/>
                <person name="Cuomo C."/>
                <person name="Ma L.-J."/>
                <person name="Henn M.R."/>
                <person name="Klein B."/>
                <person name="Goldman B."/>
                <person name="Young S."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Heiman D.I."/>
                <person name="Hepburn T.A."/>
                <person name="Saif S."/>
                <person name="Shea T.D."/>
                <person name="Shenoy N."/>
                <person name="Sykes S."/>
                <person name="Galagan J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">ER-3</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="EQ999973">
        <property type="protein sequence ID" value="OAS99711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99710">
        <property type="protein sequence ID" value="OAS99710"/>
        <property type="gene ID" value="BDCG_01105"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAS99711">
        <property type="protein sequence ID" value="OAS99711"/>
        <property type="gene ID" value="BDCG_01105"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01105"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="Transcription_factor_dom_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal_trans" evidence="2">
        <location>
            <begin position="217"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAS99710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAS99711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="668" mass="75615" checksum="314AD3EC8C905BA8" modified="2016-09-07" version="1">MDDHAEEDFNRSERAQATGFMGQSSEISWMQRLQREADHGSTQQHDDHFNGPDGLHAVPESDINDVYKDTSTTSASYHLDDLGVSISEAVEPYAIPPRETADKLFNAYLVSVHPSFPIIGKAVFTSQYNLFYDQPSAMPGHKWLAILNMIFAIAAKYSLLIQAGGGVDDRDHLIYFTRAKALSMNGDAFFSHPDLQRVQVEGLVAFYFLATGQINRSWKFSGISVRSAFALGLNLRSGTADTSDISKEIRYRVWWSLYTLEHLLSTMTGRPASIDDGVCTAPFPIPFEEENFHDENVSQLLNLHSFRDRRVRSTISRLSNISTRTSTSLPASSTSGPAANHDQAQEQVETDWLRTITPNASLYFLYFVDLTSIMQEVIRSLYTARAIHTAWVDTEHLIARLSSKTEAWRSRLPEAYDVTIRKGSATFQRQRLNLAFLYYSTKITLTRPCLCRLDRQAAHTRKLKKFTHDTAALCVSSACHMLDLIPDEPDAIGLSNMAPWWCVLHYLMQSTTVLLLELTFRARHMPDDAKTISNAMKKAIRWLHHMSQENSASHRAWMLCDGFVRRLATDIGLDVSDLPMHPRQQNPTVIQTPTMTTTSYPEPNATPWEVPHQNHLEPLASSFFVPVPYGEVMHPAICTDYDEYLLYTTATEETTNYFTPTFPDMDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0C2</accession>
    <name>A0A179U0C2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_02443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="OAT00331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT00331">
        <property type="protein sequence ID" value="OAT00331"/>
        <property type="gene ID" value="BDCG_02443"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_02443"/>
    <dbReference type="OMA" id="LMVGPII"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="4">
        <location>
            <begin position="39"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT00331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="519" mass="57946" checksum="80E6E468653608B7" modified="2016-09-07" version="1">MTDVGSHQFVKCSDRVLVPQPSQEPSDPLNWSPFWKACAMFLSTAVTFTQAFGPMALAPMFPQLIQEFDTDLAGVVKFTGVCILFLGFSNFFWVPLQTCFGRRPVLILSTLVCLIASMWRGLATSYGSFMGASILNGFGAGPAETAQPQIIADIMFLHERGAYNTLYFTFYFGALVVSPVIGGSMAHNLNWCDFWWLNVGLLGFVLVLLVFLFPETRWPRSHPVDPVEGNRVADETTAAKADSTATSSAKPSTEPDIENEHANRDPYLRKGRPSLRQFRLFSMVENPVKSLLLDFWIPWKLHLFPIVHLAAFIVSWSASVFLVVNVTQSQLFAAPPYNFNSQTVGFFNFAVIVGNGIGLATNGYLSDWISMRATKKNRGIREPEMRLPAMIPYVIIMIIGNFVVAFGYEYKWDWKIIVIIGYTAVGIQVAALPAIASTYAVDSYKPIAGSIFVTITVNKNLWGYGLSEIITPWTQRSGFIPAIMLNMGLTTFFCAWGIVFYYYGKRLRKITANSKVHQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0D2</accession>
    <name>A0A179U0D2_AJEDR</name>
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        <submittedName>
            <fullName evidence="4">ATP-dependent Clp protease ATP-binding subunit ClpX, variant</fullName>
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    <organism evidence="4 5">
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        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
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            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002623684.1"/>
    <dbReference type="EnsemblFungi" id="OAT01596">
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        <property type="gene ID" value="BDCG_05605"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05605"/>
    <dbReference type="OMA" id="YKIWTKG"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
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            <begin position="263"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="3">
        <location>
            <begin position="545"/>
            <end position="639"/>
        </location>
    </feature>
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            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="413"/>
        </location>
    </feature>
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        </location>
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            <end position="154"/>
        </location>
    </feature>
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        <location>
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            <end position="251"/>
        </location>
    </feature>
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            <end position="412"/>
        </location>
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        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT01596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="699" mass="76246" checksum="780F5B3660F299AA" modified="2016-09-07" version="1">MRGRRLREGCSRQALAKHIPNLITSNISLIFSTLCATPLCQRWLSSFAVFVLSFILTKPLFESSITPPTASFKGQLDDSKMRRLSMSFLLPFRSPLRPLDWKTPTTSPVRRRVQLSYLALYSIHRHLSTSSRCSSPSQFHRSDFTSQPFTGSYEPGLPTSGPLGSAPSFGAPRLTPKMLKQHLDQFVVGQDRAKKVLSVAVYNHYQRVQELQRREEEEEELMAQQARPEFPGQQRTIHTQRTTNDDNARSGPLPVDSSPLTLEKSNILLLGPSGVGKTLMAKTLARVLSVPFSMSDCTPFTQAGYIGEDADVCVHRLLAAANYDVAQAERGIICLDEVDKIATAKVSHGKDVSGEGVQQALLKIIEGTTIQIQAKPERSAPRSGGSLNSNPGSGSGNFGGSSFNSTPPGSSGKAEVYNVRTDNILFIFSGAFVGLNKLIMDRISRGSIGFGQPVRASSNSFSSHNASHAASTPPIPILPGSEEEALYKKHLPFFTPAPLPSGSGADEEPTYFNPLDLLTPPDLQTYGFIPELVGRIPITTALSQLTHPLLLRILTEPRNSLLAQYTTLFSLSGIELRFTTPALHKIANNAMSMATGARGLRTEMEMILGDAMFEAPGSSVKFVLVTEAVAARKEKAVYLARGQGGKFHAMIAAEESEWEEKMRKQKEGGGNNSTNNNNDNSFEQWRSRARTDTAVGGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U0D7</accession>
    <name>A0A179U0D7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_04677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999977">
        <property type="protein sequence ID" value="OAT01250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01250">
        <property type="protein sequence ID" value="OAT01250"/>
        <property type="gene ID" value="BDCG_04677"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04677"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="274" mass="31147" checksum="06B31334C19F060F" modified="2016-09-07" version="1">MGQVSASPPATVPFFHLDDCHARRVIQVVRCILATEVAEQSFGMLIDGRLTMKALRACRRIRLDEDYDEIAKYTGPSQDTISMFRSLREQFDLSHVLIKASSAERFQRSTVQPSSADFQRGLLDLVVSMVHDLAINIFGELHRFKYQNTPHQGLERALLPDFRHPKYLQSYLYPHGPTELVGYWMETRLFGGVVVFEHGNPPGEVSINPQPLPVFLCILYTCSKVPYFNRTQPGVPWIHFPYEGIMRMSDKQLDAFTQLAFTTSPVSDPAAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U1E6</accession>
    <name>A0A179U1E6_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_04404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
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                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999976">
        <property type="protein sequence ID" value="OAT01138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01138">
        <property type="protein sequence ID" value="OAT01138"/>
        <property type="gene ID" value="BDCG_04404"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_04404"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="58" mass="6581" checksum="207F056A0ACB8C7C" modified="2016-09-07" version="1">MDRSVTYIPVERQYVVKSQYTGKYQCSQASVAILIPYPDTSLGVERKPFPNNDDKNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2G0</accession>
    <name>A0A179U2G0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integral membrane protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_06411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01950">
        <property type="protein sequence ID" value="OAT01950"/>
        <property type="gene ID" value="BDCG_06411"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06411"/>
    <dbReference type="OMA" id="THYIWVF"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Git3" evidence="3">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GPR_Gpa2_C" evidence="4">
        <location>
            <begin position="232"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT01950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="423" mass="47563" checksum="9270C5CE52EF19E1" modified="2016-09-07" version="1">MPAVELLRREEPAPRIISPLPAENRGGVISFFACSLLSVLTTGPLVVWLAYRLIFWRWYYTRYPGRNQLIILVFNLLIADLHQASANLVSPYWLLRNEISIYSPACFAQGWLINFGDIASGMFVLAIAIHTFAGVVWRKMLSHVVFVGCVVGLWMFCLLVTALAPALHGRHVFVPIGAWCWIDSEYGDQRLYLHYFWIFVTEIGIIIIYPTLFFIIRHRLKSSKEFRVNGSRRPKFNKVLKIMIIYPIAYIVISLPIAAGRMSMMNGRHPGMPYFYFTGSLLMCSGWVHSILYFLTRRRLVEADIQTESGSDSSNRPNPSCDPRYEIPLTIGGGGLRGTGSRHKPSPAVLKNSRTLHTISSSTDNILDTVELSELGEANQMGVVEISTQFSSNSAPSISTPATSTQRNTSMDWPTQYQGGWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2H0</accession>
    <name>A0A179U2H0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BDCG_07136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02274">
        <property type="protein sequence ID" value="OAT02274"/>
        <property type="gene ID" value="BDCG_07136"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07136"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAT02274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="304" mass="34313" checksum="3A7FF7E218A28985" modified="2016-09-07" version="1">MDTHMGLGGNGAPPSSLSAPVPAGPAAIGVDNSSSGQEKGVLLSSNEDWDSESKLVTALSMLQQMEAKIHGLRTLVPNRLLSPLIPIVNPDIHMMAIWDRIDQILAESGGEHPPLTGMWERDYDDILKTLNREEQGEKERKNRLEEEEEKRRVASSESGWKDVVEEYKKKDIPITINVPRPADNNGRFSVAIQKLSRQFYVLQGPSYDSKSPREWQVMIVPRGNTSKMETEILDCIRSRERKWDLRYLLDMLCSYADVKRTRCLNCHKLANINAQLPTVRKPTQIESADNKTTFAWNAYHSGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U2H8</accession>
    <name>A0A179U2H8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BDCG_05346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OAT01498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="BDCG_05346"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_05346"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAT01498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="425" mass="48409" checksum="2F2CC8930811B3C2" modified="2016-09-07" version="1">MAHQTEGCVVLEYEKLRPVGLLERYSTARHHLGFYINVAVSATYTLPETCSYPLKSFIYRACKILIGQHPILSVIPVGENTDEPHFVRLPAIDLDACISFEERRHGNLVSNHSSNPDPDMDLEKLLNIQHNIPFSPPCPFWRLCILANHDHPHIFTASFIFHHAIGDGTSGMAFHKTFLRALHLELSSAESSDQVDCTIVSPNIPLLPNIEALHPMTVSIPFLLSILFREKIWNKQDPNLWTGSKITMPLENEIRLLVLSESQTLSFRDLCRKNKTTITAALHTLVAGAVFLNVSAHYSRLRCVGALSNRRWLVERISDDSMGVFVQNLHDSYHREKFFDQSGNFKFPWDEAVRSRKTIEDTINMKGKNAMPNLLKYVGNFHSELFLSKRPDRRTHELAGWSFRRVVMLQGVRLRCPPLPVVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3I0</accession>
    <name>A0A179U3I0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_17213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01707">
        <property type="protein sequence ID" value="OAT01707"/>
        <property type="gene ID" value="BDCG_17213"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_17213"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008107180" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="58" mass="6296" checksum="4E75D7B7881056CB" modified="2016-09-07" version="1">MKIDVAFTLALVLAATGITAAQRSRVELCRVGYQCRADIDCQADPECQAKAEVRTDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3J2</accession>
    <name>A0A179U3J2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_07367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02370">
        <property type="protein sequence ID" value="OAT02370"/>
        <property type="gene ID" value="BDCG_07367"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07367"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="227"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT02370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="552" mass="61571" checksum="E6936FF6F0328430" modified="2016-09-07" version="1">MDDDPNLILVIRGAPGDAAEGLELPHNRTRYSDLLDGFHKPPPDPRSRSSSPNSNSDEGDQGNNNNEPPREGSLLLTFDKPPANVTRGFTFGTSKRRCDVLLAKTSVPNISGVHFVITLENTGHLVLRDVSSRETAVSYDGWGEQYPRRHFTWILDLNDKRMSISVHLRGFRLDITLPSHASCQSQYKANVDAYVKASQDSVLSLGGLNMPSQDPTRPRSPINDPIYFPAETIGHGSFGKVYKVLDVSTGRDYASKRFLLHSADIEQMKKKPTESPAFKQHQTELVEFLNEMKIMKYLMHIVMEYMPLGSLRFQHSVIPISTTEIQLVLAQGLDALRFMHSRDITHRDIKPENILVYSRNGPFIIKLADFGLSKFGSLRTNVGTLDYRAPEFFHSQPINYDSRVDIWALGVVALEFTYGATEVNSGYDTQRVADAAKSALRSHSDSPFYFMLSRMLEIDPNNRPTAEDCFEGEPTIDFSIKHSGGTSGLITPTNNRSLSAQTSRVSASADSLRQIPAGSMQTPMPKRHLSSTSSRGHRTKRQRDSIDNASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U3J9</accession>
    <name>A0A179U3J9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_07918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02634">
        <property type="protein sequence ID" value="OAT02634"/>
        <property type="gene ID" value="BDCG_07918"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07918"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84" evidence="2">
        <location>
            <begin position="85"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="607" mass="66057" checksum="16A3C421514927BD" modified="2016-09-07" version="1">MGSTRRLTKRNTDQDNKKEVIDKPKGKQRVVKKIPPAVIKQAKGLAIFTAMRTGLWFSGSGGGGILVARIKETGEWSPPSGIMMHTVGLGFLAGVDIYDCVVVINTYEALEAFKAVRRTLGGELSPVAGPFGIGGAVESEVHKRRAPVWTYLKSRGVYAGVQMDETIVIERTDENERFYGERIRVADILAGKAKNPPASIGTLIETIKAAQGDADVDETMLPPPGEAPGDADIETDLFGVPPPDDPDPFGVKALEREGVIIREAGTNRIPSDDMFEFRPSPTSPLYNRLSRFSMESSQRASWRTSVQSTASADRATQTDDFIDDQPPTAPISTSRSSSDNLHISDRDNSTRTQCTTPLQENTTSITRGSLVIQDQSLPGDTSQARPTSPTFTRARLVTIAKPIPPPLPPRNTARISLVSGSSSRTSEREAESQIERYEDVDKDEVHGNSNDDGKCTKPGSVGEGASSVDDDSLNKCDSIQDTFKKPAITKEIKCAEQEESSTKGGIQLEDVLQESTFAEEDSDKNLTEMQTKEEDTVEDASLKGAEPIVEERSGGGTESTDEAEFGTPTEQPQQEGSLDEDKEEFHSISTSPTPPKTRKKPRNRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4K0</accession>
    <name>A0A179U4K0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02925">
        <property type="protein sequence ID" value="OAT02925"/>
        <property type="gene ID" value="BDCG_08694"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08694"/>
    <dbReference type="OMA" id="SAGPRIN"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="419" mass="45101" checksum="0C61BB0EEAFC871D" modified="2016-09-07" version="1">MQATNKRKAADEEEGQQQEHGHQRPRKWPERSSRASDINYDVREYYRGIQLDEKIYSTSSQKKDMPRKSGPDGTSHIDAQLAAATCTPPAQRAVMPTLTWEPCFECIQELCRNPREMKCRPGPCNSKCRHCDATYKACLKPSGLGPRLAKIQTIASSIITTPSALGWPDEVSRREKRLSEEFTIFQEEMETYIAGADMAISPPLVSATDPTPTAIGGGAGSVKTPDKPLLMATLSSPFRAVKTESPPGSSPYFKMSPTAKMLIMPPSMTDKATVTSSPPLFAHFTTKGDGSNGDGDGDGDDLKLPTPTPSPPELGQDPAPTAQMESKLRTTTTKANTVASSIKVATEENTTGGDIQAASTDLNATSFNLGAKLLTVLGSIESNLARIADTLEVKNRRGNGSDGDCGIGGEMVANRAYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4K2</accession>
    <name>A0A179U4K2_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 transcription factor, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02258">
        <property type="protein sequence ID" value="OAT02258"/>
        <property type="gene ID" value="BDCG_07119"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07119"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="PTHR36167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="394" mass="42593" checksum="98DCFC2D9E9A8836" modified="2016-09-07" version="1">MDRPASDYAQPEQTAAAASGQYTSQPEARPATQYTAPAEGRPSNISSSNTPQPDYGLNPPAPAPPQTQPQQQQQQQHQAQAQPQPQAPPPPAARPPPGPYPEYLTRQPQYHHAPHTQPGGAAGMAQATNPSIAASSPTYPPPYSPYNPQGHEMTQYPGHPPPQMYGRPDWPPHQYGQHPHGLPGPYSSPGTTVGSASPAATAGPRPGQTHSLSQVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGAKRTPEEFKEIRKEWKARKKEEENQRKAAEERERAAAQANQQVDGSAPADPSQAAQSTSYPGGIRPQLPPIGYQPADGQVPGQYGASAGAGLVYPPSNGQMAAPYPPANYPHSPYGQGNQVYQPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4K5</accession>
    <name>A0A179U4K5_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 transcription factor, variant 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BDCG_07119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999980">
        <property type="protein sequence ID" value="OAT02259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02259">
        <property type="protein sequence ID" value="OAT02259"/>
        <property type="gene ID" value="BDCG_07119"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_07119"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="PTHR36167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAT02259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="391" mass="42488" checksum="1468C9A086C51AD5" modified="2016-09-07" version="1">MDRPASDYAQPGLHSPNPTLAEPQSERPAAEQTAAAASGQYTSQPEARPATQYTAPAEGRPSNISSSNTPQPDYGLNPPAPAPPQTQPQQQQQQQHQAQAQPQPQAPPPPAARPPPGPYPEYLTRQPQYHHAPHTQPGGAAGMAQATNPSIAASSPTYPPPYSPYNPQGHEMTQYPGHPPPQMYGRPDWPPHQYGQHPHGLPGPYSSPGTTVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGAKRTPEEFKEIRKEWKARKKEEENQRKAAEERERAAAQANQQVDGSAPADPSQAAQSTSYPGGIRPQLPPIGYQPADGQVPGQYGASAGAGLVYPPSNGQMAAPYPPANYPHSPYGQGNQVYQPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4K9</accession>
    <name>A0A179U4K9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_17291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01921">
        <property type="protein sequence ID" value="OAT01921"/>
        <property type="gene ID" value="BDCG_17291"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_17291"/>
    <dbReference type="OMA" id="IHCAIAH"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="176"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT01921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="389" mass="44033" checksum="A00C9DF9AEEE6BC0" modified="2016-09-07" version="1">MAPVFSQHRHQSSLEGIINFSGPQPFAADQRARAQRRFYSIINHFDITDNSRRVGYRRPLLVRYTYEYSRSELSQDIFLRAFFEFMKVDVAGEEDIDFDDEGLENQLGKNLITFADFLLDNFFLPLKASGQHTPQPSPAHLSAIQRAQGGMHEFTGTPDRISVLRGSCLIRDRHRCVISRKFDQREAIVRLTQHGHAAQDDEGNPLQGQLSMILEVAHILPHSLTQANADSQLDDSKKAALMILNMFDCDVSHLIDGVNIDRPFNAMSLTRDLHTHFGNFTVFFEAVPDQEHTYRIDTFLPPGILPDIPVTRILYLINDRSIEPPSPRLLALHHAIARILHLSGAGEYIDNILRDMEETGIQEDGSTELGRMVNLTLGGWLDSVVDSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4L4</accession>
    <name>A0A179U4L4_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carnitine O-acetyltransferase, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BDCG_08260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999982">
        <property type="protein sequence ID" value="OAT02750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02750">
        <property type="protein sequence ID" value="OAT02750"/>
        <property type="gene ID" value="BDCG_08260"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08260"/>
    <dbReference type="OMA" id="HILVMRR"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="PTHR22589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carn_acyltransf" evidence="9">
        <location>
            <begin position="38"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAT02750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="814" mass="89783" checksum="F5FE8F651CBDCF01" modified="2016-09-07" version="1">MAGAEDANFNSNSDPNSNPPQTVHKGITFANQDSLPKLPIPDLETTCTRYLECLAPLQSAREQEETRAAVHEFLRTDGPELQNKLKKYATSKSSYIEQFWYDSYLNYDNPVVLNLNPFFLLEDDPTPSRNNQVTRAASLVVSALSFVRAVRREELAPDIVRGKPLCMFQYSRLFGTARVPTENGCIIGQDSAAKHMVVLCRGQFYWFDVLDENNDLLMSERDISLNLQVIIEDAEQTPIQEAAKGALGVLSTENRKIWSGLRDILTKDPGSNNAECLNIVDTALFVLCLDSTEPSNTAELCANMLCGTNEVVKGVQIGTCTNRWYDKLQIIVCKNGSAGINFEHTGVDGHTVLRFASDVYTDTILRFARSINGQAPSLWATTSPPPSKRSPESFASNVSTTPHKLEWDMGPELSIALRFAESHLADLLHQHEFQVLDFNGYGKNFITSMGFSPDAFVQMAFQAAYYGLYGLVENTYEPAMTKFFLHGRTEAVRTVSHESVEFVRTFWDERPAAEKVAALRKATEKHTAVTKICSQGKGQDRHLYALYCLWQRSFDDGPPSANGYSSPVENGSKVDPSSPLPAQGSTTVSRPSSSSGDGVSSSYSTSSSRNIRLQQLAHTPALFNDAGWDKINNTILSTSNCGNPSLRHFGFGPTSGDGFGIGYIIKDDSISICASSKHRQTTRFIQSLEAYLYEIRKLLRSTQHKPVVPSSVRERQMDAEARSAPLAVTLGERVKGKGRMVRVAPQHVVGGGRGGETPMTDSAEAEAEDDGMGGYGFFDAGMLLYALKGLQADRDRDKPPKRKLVGKVLKLNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4L8</accession>
    <name>A0A179U4L8_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_08756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02945">
        <property type="protein sequence ID" value="OAT02945"/>
        <property type="gene ID" value="BDCG_08756"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08756"/>
    <dbReference type="OMA" id="EREIPCY"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="374" mass="42919" checksum="5C7411120ABEC2F4" modified="2016-09-07" version="1">MSSQGHFPYPGRAAIRDEAYYPVSSEIAAFPPPPRSVLNREYEPQTYRPTAEAPGLYHSSGNRTSPLSWEHSRERLEPSRSPDRGRFNEHHILYSNTGRILVNSSPYDRYSYVSSPANLGPIGALPRPPPCFGERDAQPGYSSHDFVMRDPDSPTSMETFDLFPEHTKRRIPENTKSSAKHHQQRRPSNRDEFDGPTQLLNKLSPGTIAEQEKDLPQLPTSLDVQEQDRILCEVNDCLSRCAFNFVAKYQFPIPLEPDKRQVRIPADREWTEWVYLLKRLATKRRIPARVLYNNQIKQFVTVLENSLEMRHAAKHQSRPVKDDRNILQLISAGTQVAKILMDASAMEFLDQLYSRTENLIYERRSYLGGALSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U4L9</accession>
    <name>A0A179U4L9_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RECA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_06368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999978">
        <property type="protein sequence ID" value="OAT01931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT01931">
        <property type="protein sequence ID" value="OAT01931"/>
        <property type="gene ID" value="BDCG_06368"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_06368"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT01931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="506" mass="55532" checksum="828FB200F02D5A62" modified="2016-09-07" version="1">MATQEEDIAKFSSPDEARQKKRPKGSFHAFGRVKLPPLSTWEGDGAVSTGLPRLDAALALPSGLRPSPLGPGRNSQRYNGHQDVPAKGIKRGDVTEVTGPRGVGKTSLAMGIAARVLQAAQKVIWIDTAGPMNPTRLKDICQRVRVSGLSDNSSDAASNGGRSDEILNELIYFHPPTLAHLLALISHPPKGFPPQETGLIVIDSISSLFTSEYRTKLPPRNSNPKHRTTAESKDERTRWKIIGNLVMDLKKLAARLNCVVIVINEMASRFRGTQPPVLHEALSGITWDSGVTTRIKLCWHWLPPSLRSRVRMKRVRFAEVAKVEKVGLMHGRSLRIVPFVIKKTGLHEFGPRPGGTPLSIFTRISKRPHVVHVRSKRKLDLVIDGSPDTSRKHRMEPATTTPGFKLQNSELDEGTGGTTPSDASLALSIKEEDEQDQGYEYEWLDEEGIEFVDETVDGEEPGSDDHAGSGDGKGDDSPCLSHNMGEDIDDDTVLLLQNISSEDEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U6P7</accession>
    <name>A0A179U6P7_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BDCG_17872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02979">
        <property type="protein sequence ID" value="OAT02979"/>
        <property type="gene ID" value="BDCG_17872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_17872"/>
    <dbReference type="OMA" id="WIREIPA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005750">
        <property type="term" value="C:mitochondrial respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="PTHR28254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAT02979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="95" mass="10389" checksum="9E6987A30F2D5D98" modified="2016-09-07" version="1">MVSPSAARSAAAPASTTNHRSPFALRYKKQPHYAGFPLKTSVRYGTIATAFGATAGIFAVFFFGEVPRVRKDILMNIPVIGGYWERSIPPEDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U706</accession>
    <name>A0A179U706_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BET3 family protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_09141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999986">
        <property type="protein sequence ID" value="OAT03099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03099">
        <property type="protein sequence ID" value="OAT03099"/>
        <property type="gene ID" value="BDCG_09141"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09141"/>
    <dbReference type="OMA" id="RTNHHGV"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043087">
        <property type="term" value="P:regulation of GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="PTHR12817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT03099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="158" mass="17989" checksum="7827196C8EBDD350" modified="2016-09-07" version="1">MPHISKMYRLVYSSFLCISGLGLGVSIGDEWIFSRDRPRFTDNLDVIKFLCKDFWTILFRKQIDNLKTNHRGVYVLTDNAFRPLIRMSMSNRNEATAKAQSYLWFPCGIIRGGLASMGITATVQAESSDLPSATFQIKTMQITQPPTQPQQQLQHPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U716</accession>
    <name>A0A179U716_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BDCG_08904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002622293.1"/>
    <dbReference type="EnsemblFungi" id="OAT02997">
        <property type="protein sequence ID" value="OAT02997"/>
        <property type="gene ID" value="BDCG_08904"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_08904"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="PTHR10333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="652"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="251"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="673"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="682"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="697"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAT02997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="713" mass="73813" checksum="B3F4079AAAE51ED2" modified="2016-09-07" version="1">MATTLPPGASHAATTTTNNSTAGPGPSTTSIRQSARQTRTNPSRTSKTASRATFAGLGLHGSSGVYGLGAGAGVGAAAAAAAGGVGGPGLEAFGAAAGAHHIPHGLYPAITHFTDAITALPKEFRRHASLLKEVDGKAWALEEALAKQLDAATASTPYAKLMQGGVPTKEPINYDSPEALARRKIFFDLRATLSDLMITTDEKNHVLWNANNELEKQVRRIDMTFPYVEGEISEEARLGSLTHWAYSNKTAAKTAGNTSERPRRETASTRDQNLAAALEGEARREGGSRKHRRTQADADGEDGRIPSRKGTGGKGRSGETPSIPIGTGGAVASSAAPAKRRRVEKPQPTASAAVAAMERSVSATTNTGTGRGAAKEPSATDGVKKRVRAPNANPGGRKRANTAASATGSPALFPSSAVPSLSASIKAGSPAPNTLPGPQSSRSQLGSSQVATGRQRPSSSASNRASNSKKPPSSDLKPSTLSRDTASARMEPGFSTPAEVNGDGKANASISAASRPAEPVPKREDTAPASYNSVSNGTKTEPNSESNSAPPQPKGRSSKNSTPVGSTFPESSQQQPQPQRTTRPRGGNTTVADGGGPGGSSTTSNTVTGITKRSHKKGAGLAATQQLIAAVAATEDEDSSRQGDDEEEEGEPRYCYCNQVSFGEMVACDNETCPREWFHLSCVGLSRAPLKSSKWYCNECKDNQRKGKSGNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U7Q0</accession>
    <name>A0A179U7Q0_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_17872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999984">
        <property type="protein sequence ID" value="OAT02981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT02981">
        <property type="protein sequence ID" value="OAT02981"/>
        <property type="gene ID" value="BDCG_17872"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_17872"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005750">
        <property type="term" value="C:mitochondrial respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="PTHR28254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAT02981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="69" mass="7637" checksum="E06B171637B66276" modified="2016-09-07" version="1">MTVISLTHRHFLFPLLNSGTIATAFGATAGIFAVFFFGEVPRVRKDILMNIPVIGGYWERSIPPEDNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A179U955</accession>
    <name>A0A179U955_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-containing protein, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BDCG_09108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999985">
        <property type="protein sequence ID" value="OAT03082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="OAT03082">
        <property type="protein sequence ID" value="OAT03082"/>
        <property type="gene ID" value="BDCG_09108"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_09108"/>
    <dbReference type="OMA" id="FNEEWDA"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033191">
        <property type="entry name" value="Slm1/Slm2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF12">
        <property type="entry name" value="PTHR31941:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="437"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="260"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAT03082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="619" mass="69032" checksum="960D6A53F3188E3A" modified="2016-09-07" version="1">MAARPRTPLHDEYTTAPNSTEPSHANQVNGSASRLTSYMATPSSIVPSDFQVRGVPVQNSTQTPQVSRFHEDMSSRRGSSVIDGAPPTTNNLHRSDSQMSAAQSLLPSRASGTLKKKPSLSKKGSLRRGGSRRSSRAGSVRSMALGEKEKYGMVDGDEVNSAFYVPIPTSGSPTDVLAARFQAWRKVLKDLIMVFREIQKSYEIRSKTLLSVSNSMNNVVFPATFLATGGISDATKILKEYHRQAVVESAKARDVELEVIKQLTGLRSDLQQKIKEIKSLSGDFRNSVDKELEGTRKAVRNLQEALGLVDTDPAATSGKGDPFLVKCAVHRQLEKQIDEENYLHRAFLNLENSGRELERIVVTEIQKTYNIYANILKRDADAAYDAAGQLIEGPISVPQDHEWDSFVSHNDHLVDPLLPIRDFQHINYPGKNHPAAAEVRAGMLERKSKYLKSYTPGWYVLSPTHLHEYKSADRIEYQNPVMSLYLPEQKLGSHSQSGSASHKFMLKGRQTGSMHRGHSWVFRAESHDTMLEWYNDIKNLAEKTGEDRNAFVRKHSRQLSGGLYRAGSISSSEGVMDEDEADETPYSADHVIVNQAPPVVETQWQQRPQPEKVLETLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>C5GBJ3</accession>
    <name>C5GBJ3_AJEDR</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BDCG_01684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="EQ999974">
        <property type="protein sequence ID" value="EEQ86564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002624753.1"/>
    <dbReference type="EnsemblFungi" id="EEQ86564">
        <property type="protein sequence ID" value="EEQ86564"/>
        <property type="gene ID" value="BDCG_01684"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_01684"/>
    <dbReference type="eggNOG" id="ENOG502QU4J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034224_0_1_1"/>
    <dbReference type="OMA" id="WVAEWVE"/>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="PTHR28265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EEQ86564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="496" mass="52403" checksum="2919142D7DB7579D" modified="2009-07-28" version="1">MSKSGKTAPTNDELLAQFDDLGVDDGATQAAGGTQEKSEQDLLAELQDLASQRPPTPRTSSTLNKSPKPTSATTPPSGRLSDDKMPPRKSGDSSRAYHTSITPPETTSSDAGDTPTSEEAGKTGGGGGGGWWGGIFATASAAVKQAEAAVKEIQKNEEAQKWADQVRGNVGVLRGLAIPTFTSLLHTLAPPISSHERLQIHITHDLSGYPSLDPLIYSVFSRVMSQVEGGDLLVIQRGREAAPRRGSDAHVGHSSSAGWNDGPWWRTVSVGKPRSISAIKGAVAGTKLVRASAEAYATEYFSTRGGVEEAAKQASEILSESNPVRSSDIFLAIQAISQPTPPELFQAGPSGDTEKPAQGIVEVKEDIEEEVFFALYLHDPIHGIAFHAVTQAVPQKWIDWLDAAPPSPPNPDNPDDFVHSTMPDAIAEIIESGGVDPREWVSEWIEEALTLGVGVVAQRYVARRMGVGEGGVGRGKMKAEQATAVESGAGEAARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-07-28" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>C5GFR2</accession>
    <name>C5GFR2_AJEDR</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homocitrate synthase</fullName>
            <ecNumber evidence="7">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BDCG_03252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)</name>
        <name type="synonym">Blastomyces dermatitidis</name>
        <dbReference type="NCBI Taxonomy" id="559297"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Onygenales</taxon>
            <taxon>Ajellomycetaceae</taxon>
            <taxon>Blastomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2015" name="PLoS Genet." volume="11" first="E1005493" last="E1005493">
            <title>The dynamic genome and transcriptome of the human fungal pathogen Blastomyces and close relative Emmonsia.</title>
            <authorList>
                <person name="Munoz J.F."/>
                <person name="Gauthier G.M."/>
                <person name="Desjardins C.A."/>
                <person name="Gallo J.E."/>
                <person name="Holder J."/>
                <person name="Sullivan T.D."/>
                <person name="Marty A.J."/>
                <person name="Carmen J.C."/>
                <person name="Chen Z."/>
                <person name="Ding L."/>
                <person name="Gujja S."/>
                <person name="Magrini V."/>
                <person name="Misas E."/>
                <person name="Mitreva M."/>
                <person name="Priest M."/>
                <person name="Saif S."/>
                <person name="Whiston E.A."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Goldman W.E."/>
                <person name="Mardis E.R."/>
                <person name="Taylor J.W."/>
                <person name="McEwen J.G."/>
                <person name="Clay O.K."/>
                <person name="Klein B.S."/>
                <person name="Cuomo C.A."/>
            </authorList>
            <dbReference type="PubMed" id="26439490"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1005493"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ER-3 / ATCC MYA-2586</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="7"/>
    <dbReference type="EMBL" id="EQ999975">
        <property type="protein sequence ID" value="EEQ88132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="5039.XP_002627640.1"/>
    <dbReference type="EnsemblFungi" id="EEQ88132">
        <property type="protein sequence ID" value="EEQ88132"/>
        <property type="gene ID" value="BDCG_03252"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:BDCG_03252"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002039">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth_fun/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="66"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EEQ88132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002039"/>
        </source>
    </evidence>
    <sequence length="472" mass="51692" checksum="D65C217EE4908CCD" modified="2009-07-28" version="1">MCTTCTGAKATNGQTNGQVNGTNGTNGTNDGFTAVQTRENPHPHVARNPYGHNAGVTDFLSNVSRFKIIESTLREGEQFANAFFDTEKKIEIAKALDDFGVDYIELTSPCASEQSRKDCEAICKLGLKAKILTHIRCHMDDARVAVETGVDGVDVVIGTSSYLREHSHGKDMTYIKNTAIEVIEFVKSKGIEIRFSSEDSFRSDLVDLLSIYSAVDQVGVNRVGIADTVGCASPRQVYELVRVLRGVVKCDIEIHLHNDTGCAIANAYCALEAGATHVDTSVLGIGERNGITPLGGLMARMVAADRDYVKSKYKLEKLKDLEDLVAEAVQVNIPFNNYITGFCAFTHKAGIHAKAILNNPSTYEILNPADFGMTRYVHFASRLTGWNAIKSRAQQLKIEMTDTQYKECTAKIKQLADIRPIAVDDADSIIRAYHRNIKLGENKPLLELTAAEKEALAEKEKEEAGKVVEVPA</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>